PHLDB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.20167487
2chondrocyte proliferation (GO:0035988)5.37488184
3desmosome organization (GO:0002934)5.33883381
4bundle of His cell to Purkinje myocyte communication (GO:0086069)5.31056534
5collagen fibril organization (GO:0030199)4.67228508
6cell adhesion mediated by integrin (GO:0033627)4.56689046
7regulation of transforming growth factor beta2 production (GO:0032909)4.42311771
8negative regulation of fibrinolysis (GO:0051918)4.34790579
9endodermal cell differentiation (GO:0035987)4.05523194
10sequestering of extracellular ligand from receptor (GO:0035581)3.99829390
11skin morphogenesis (GO:0043589)3.99203471
12endocardial cushion development (GO:0003197)3.91990832
13regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.89358404
14hippo signaling (GO:0035329)3.83085651
15epoxygenase P450 pathway (GO:0019373)3.77461986
16negative regulation of fatty acid transport (GO:2000192)3.75426906
17positive regulation of endothelial cell apoptotic process (GO:2000353)3.66630170
18wound healing, spreading of epidermal cells (GO:0035313)3.59823941
19vascular endothelial growth factor signaling pathway (GO:0038084)3.59220649
20cell migration involved in sprouting angiogenesis (GO:0002042)3.57653856
21metanephric mesenchyme development (GO:0072075)3.57389155
22neuron projection extension involved in neuron projection guidance (GO:1902284)3.56963559
23axon extension involved in axon guidance (GO:0048846)3.56963559
24gap junction assembly (GO:0016264)3.53129858
25basement membrane organization (GO:0071711)3.46819501
26protein heterotrimerization (GO:0070208)3.43704269
27retina vasculature morphogenesis in camera-type eye (GO:0061299)3.41624222
28keratinocyte proliferation (GO:0043616)3.41501559
29kidney mesenchyme development (GO:0072074)3.38323879
30epithelial cell-cell adhesion (GO:0090136)3.36664156
31regulation of fibrinolysis (GO:0051917)3.35942946
32mesodermal cell differentiation (GO:0048333)3.32633202
33glomerular basement membrane development (GO:0032836)3.28246626
34regulation of plasminogen activation (GO:0010755)3.27506803
35regulation of cardioblast differentiation (GO:0051890)3.27355275
36regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.26246373
37bone trabecula formation (GO:0060346)3.25293342
38renal filtration (GO:0097205)3.24052373
39notochord development (GO:0030903)3.21402912
40cellular response to vitamin D (GO:0071305)3.18526117
41insulin-like growth factor receptor signaling pathway (GO:0048009)3.13648874
42Golgi transport vesicle coating (GO:0048200)3.13303620
43COPI coating of Golgi vesicle (GO:0048205)3.13303620
44smooth muscle tissue development (GO:0048745)3.05227571
45glomerular visceral epithelial cell development (GO:0072015)3.05043575
46blood vessel endothelial cell migration (GO:0043534)3.04896323
47protein localization to cell surface (GO:0034394)3.03744883
48apoptotic cell clearance (GO:0043277)3.03459626
49cellular response to vitamin (GO:0071295)3.01840500
50regulation of type B pancreatic cell apoptotic process (GO:2000674)3.01813088
51plasma membrane repair (GO:0001778)2.99773931
52regulation of hippo signaling (GO:0035330)2.97237551
53regulation of tight junction assembly (GO:2000810)2.94894640
54craniofacial suture morphogenesis (GO:0097094)2.94886235
55negative regulation of chondrocyte differentiation (GO:0032331)2.94810597
56midgut development (GO:0007494)2.91114778
57wound healing, spreading of cells (GO:0044319)2.90601983
58endothelial cell morphogenesis (GO:0001886)2.88315548
59lymphangiogenesis (GO:0001946)2.87645473
60negative regulation of keratinocyte proliferation (GO:0010839)2.86664864
61G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.86462076
62regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.83998209
63UDP-N-acetylglucosamine metabolic process (GO:0006047)2.83921096
64pericardium development (GO:0060039)2.82129050
65substrate-dependent cell migration (GO:0006929)2.79490699
66mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.78448290
67cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.78135603
68collagen metabolic process (GO:0032963)2.73898714
69substrate adhesion-dependent cell spreading (GO:0034446)2.73353204
70mesenchymal-epithelial cell signaling (GO:0060638)2.73168117
71maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72729000
72adherens junction assembly (GO:0034333)2.71610068
73positive regulation of fatty acid beta-oxidation (GO:0032000)2.71243036
74paraxial mesoderm development (GO:0048339)2.70454237
75ventricular cardiac muscle cell development (GO:0055015)2.68830770
76polarized epithelial cell differentiation (GO:0030859)2.68709672
77positive regulation of epithelial to mesenchymal transition (GO:0010718)2.65095845
78cell-substrate junction assembly (GO:0007044)2.64921322
79glomerular filtration (GO:0003094)2.64698874
80positive regulation of blood vessel endothelial cell migration (GO:0043536)2.64459026
81regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.63680156
82extracellular matrix disassembly (GO:0022617)2.63509945
83tight junction assembly (GO:0070830)2.62843725
84collagen catabolic process (GO:0030574)2.60892317
85lung vasculature development (GO:0060426)2.60382183
86planar cell polarity pathway involved in neural tube closure (GO:0090179)2.59711598
87multicellular organismal macromolecule metabolic process (GO:0044259)2.58059712
88regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.55319344
89positive regulation of collagen biosynthetic process (GO:0032967)2.54481017
90omega-hydroxylase P450 pathway (GO:0097267)2.51270503
91negative regulation of DNA repair (GO:0045738)2.50896926
92regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.50641389
93cell migration involved in heart development (GO:0060973)2.50529958
94glomerular epithelial cell development (GO:0072310)2.49071346
95regulation of SMAD protein import into nucleus (GO:0060390)2.48462672
96multicellular organismal metabolic process (GO:0044236)2.47947615
97cranial suture morphogenesis (GO:0060363)2.47757763
98regulation of transforming growth factor beta1 production (GO:0032908)2.47616285
99positive regulation of cartilage development (GO:0061036)2.47000732
100mesenchyme development (GO:0060485)2.46257538
101sarcomere organization (GO:0045214)2.46031393
102nuclear pore complex assembly (GO:0051292)2.45790418
103cell junction assembly (GO:0034329)2.45760237
104dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44694820
105regulation of transforming growth factor beta production (GO:0071634)2.44553948
106positive regulation of extracellular matrix organization (GO:1903055)2.44525395
107multicellular organismal catabolic process (GO:0044243)2.43862104
108chondrocyte development (GO:0002063)2.43518413
109negative regulation of cartilage development (GO:0061037)2.43452643
110protein retention in ER lumen (GO:0006621)2.43354968
111protein carboxylation (GO:0018214)2.43067509
112peptidyl-glutamic acid carboxylation (GO:0017187)2.43067509
113peptidyl-proline hydroxylation (GO:0019511)2.42467401
1144-hydroxyproline metabolic process (GO:0019471)2.42161942
115cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.42112068
116COPII vesicle coating (GO:0048208)2.42106320
117cell-substrate adherens junction assembly (GO:0007045)2.41288600
118focal adhesion assembly (GO:0048041)2.41288600
119branching involved in salivary gland morphogenesis (GO:0060445)2.41223931
120fibrinolysis (GO:0042730)2.40840601
121lymph vessel development (GO:0001945)2.40743156
122regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.40335703
123respiratory tube development (GO:0030323)2.40322452
124stress fiber assembly (GO:0043149)2.40293867
125positive regulation of macrophage activation (GO:0043032)2.39849588
126morphogenesis of an epithelial sheet (GO:0002011)2.38911766
127positive regulation of collagen metabolic process (GO:0010714)2.37951433
128ER overload response (GO:0006983)2.37020637
129glycoprotein catabolic process (GO:0006516)2.36243691
130anterior/posterior axis specification, embryo (GO:0008595)2.34880926
131cell-cell junction assembly (GO:0007043)2.33949442
132atrioventricular valve morphogenesis (GO:0003181)2.32395954
133regulation of centriole replication (GO:0046599)2.32182705
134endocrine hormone secretion (GO:0060986)2.30837589
135embryonic foregut morphogenesis (GO:0048617)2.29869131
136regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.29392379
137fibroblast migration (GO:0010761)2.28048182
138negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.26660850
139regulation of keratinocyte proliferation (GO:0010837)2.26036502
140muscle cell migration (GO:0014812)2.23348245
141negative regulation of activin receptor signaling pathway (GO:0032926)2.20507297
142cell junction organization (GO:0034330)2.20132377
143positive regulation of osteoblast proliferation (GO:0033690)2.19158448
144ribosome assembly (GO:0042255)2.18003268
145cytoskeletal anchoring at plasma membrane (GO:0007016)2.15080999
146regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.14252656
147negative regulation of cardiac muscle tissue development (GO:0055026)2.11462462
148regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.10982325
149wound healing (GO:0042060)2.10209455
150membrane raft organization (GO:0031579)2.09675924
151artery development (GO:0060840)2.09315959
152genitalia morphogenesis (GO:0035112)2.09104110
153positive regulation of catenin import into nucleus (GO:0035413)2.08788051
154nuclear pore organization (GO:0006999)2.08092629
155actomyosin structure organization (GO:0031032)2.07728910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.61850489
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.94003546
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.38023126
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.67516021
5CLOCK_20551151_ChIP-Seq_293T_Human3.52147007
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.17433673
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.79008913
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.75925311
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.74573593
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.57481708
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.49776683
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.43188813
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.40093395
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.38338964
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.38252710
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.35860240
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.35640044
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.33620391
19* EP300_21415370_ChIP-Seq_HL-1_Mouse2.30853594
20* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.27639401
21* CJUN_26792858_Chip-Seq_BT549_Human2.23969628
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.21261710
23CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.17486303
24BRD4_25478319_ChIP-Seq_HGPS_Human2.13895792
25ESR1_21235772_ChIP-Seq_MCF-7_Human2.13243025
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08540367
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.07879670
28HIF1A_21447827_ChIP-Seq_MCF-7_Human2.05550915
29NRF2_20460467_ChIP-Seq_MEFs_Mouse2.04021385
30NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.04021385
31PPAR_26484153_Chip-Seq_NCI-H1993_Human2.00630212
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.97094340
33* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.93398108
34* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.88586258
35* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.88586258
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.83677236
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.81113116
38* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.78323639
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.75965594
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.72572597
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69688210
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68919636
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.66307954
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.64122955
45* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64106402
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.61180043
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.55237475
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54709791
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52156861
50* SOX2_20726797_ChIP-Seq_SW620_Human1.52007007
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51536020
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50403428
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50144629
54ZNF263_19887448_ChIP-Seq_K562_Human1.48652376
55* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.46397146
56AHR_22903824_ChIP-Seq_MCF-7_Human1.44691328
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44499241
58AR_21909140_ChIP-Seq_LNCAP_Human1.42142126
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41670440
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41133978
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40715748
62ATF3_27146783_Chip-Seq_COLON_Human1.38694012
63UBF1/2_26484160_Chip-Seq_HMECs_Human1.37753036
64TP53_16413492_ChIP-PET_HCT116_Human1.35134404
65* TBX20_22080862_ChIP-Seq_HEART_Mouse1.34286005
66* TBX20_22328084_ChIP-Seq_HEART_Mouse1.34286005
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34050291
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33407092
69TP53_18474530_ChIP-ChIP_U2OS_Human1.33027140
70ISL1_27105846_Chip-Seq_CPCs_Mouse1.32534045
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.29359509
72FUS_26573619_Chip-Seq_HEK293_Human1.28781045
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28666920
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.28249469
75* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27303228
76* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.26400827
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.26241009
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23842146
79SMAD3_21741376_ChIP-Seq_HESCs_Human1.23234925
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22802115
81CDX2_22108803_ChIP-Seq_LS180_Human1.21722323
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21141165
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.20908451
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.20154243
85* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.19864688
86TCF4_18268006_ChIP-ChIP_LS174T_Human1.19399116
87GATA4_25053715_ChIP-Seq_YYC3_Human1.17327148
88EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15961200
89* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13689753
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13666035
91GATA3_24758297_ChIP-Seq_MCF-7_Human1.13577257
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11569382
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10625999
94SMAD4_21799915_ChIP-Seq_A2780_Human1.10301482
95SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10066771
96* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08975620
97* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08864059
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08829905
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08300047
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08166191
101TP53_20018659_ChIP-ChIP_R1E_Mouse1.07675940
102ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07658356
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06706763
104PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06569051
105* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06448078
106SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06119986
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06040705
108EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04496052
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03696395
110FLI1_27457419_Chip-Seq_LIVER_Mouse1.02379625
111* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01317316
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01269509
113GBX2_23144817_ChIP-Seq_PC3_Human1.01003648
114RACK7_27058665_Chip-Seq_MCF-7_Human1.00960172
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00583464
116FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00009721
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99252802
118CDX2_20551321_ChIP-Seq_CACO-2_Human0.99177024
119* SOX17_20123909_ChIP-Seq_XEN_Mouse0.98612608
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97686279
121TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96702935
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96397065
123PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95846482
124TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95615430
125* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94549946
126TAF15_26573619_Chip-Seq_HEK293_Human0.94004904
127FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93978311
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93595842
129ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93187481
130P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93126068
131TP63_23658742_ChIP-Seq_EP156T_Human0.93109691
132ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92751232
133TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92241847
134GATA6_25053715_ChIP-Seq_YYC3_Human0.91979125
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90297264
136PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89879481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.71474881
2MP0003705_abnormal_hypodermis_morpholog3.67205818
3MP0005275_abnormal_skin_tensile3.63108670
4MP0005503_abnormal_tendon_morphology3.35796781
5MP0003950_abnormal_plasma_membrane3.25502693
6MP0004272_abnormal_basement_membrane3.14900359
7MP0003279_aneurysm2.88831216
8MP0001958_emphysema2.73493261
9MP0009384_cardiac_valve_regurgitation2.69422831
10MP0006054_spinal_hemorrhage2.34999315
11MP0005623_abnormal_meninges_morphology2.30913233
12MP0009053_abnormal_anal_canal2.25568351
13MP0010368_abnormal_lymphatic_system2.24903122
14MP0009697_abnormal_copulation2.14944596
15MP0003566_abnormal_cell_adhesion2.13619281
16MP0002139_abnormal_hepatobiliary_system2.11858936
17MP0003252_abnormal_bile_duct2.09917634
18MP0010352_gastrointestinal_tract_polyps2.08098976
19MP0001661_extended_life_span1.98472721
20MP0000579_abnormal_nail_morphology1.88602971
21MP0010030_abnormal_orbit_morphology1.85875128
22MP0005360_urolithiasis1.79710033
23MP0003385_abnormal_body_wall1.79009196
24MP0002295_abnormal_pulmonary_circulatio1.76550922
25MP0005023_abnormal_wound_healing1.72436519
26MP0005257_abnormal_intraocular_pressure1.66722677
27MP0003942_abnormal_urinary_system1.62541737
28MP0003091_abnormal_cell_migration1.60883989
29MP0000537_abnormal_urethra_morphology1.59338009
30MP0005508_abnormal_skeleton_morphology1.57605578
31MP0000534_abnormal_ureter_morphology1.56095145
32MP0002060_abnormal_skin_morphology1.54832848
33MP0010678_abnormal_skin_adnexa1.50212400
34MP0001879_abnormal_lymphatic_vessel1.48899184
35MP0000767_abnormal_smooth_muscle1.46404920
36MP0003115_abnormal_respiratory_system1.45312594
37MP0009250_abnormal_appendicular_skeleto1.45016409
38MP0000751_myopathy1.43956340
39MP0002896_abnormal_bone_mineralization1.41583538
40MP0003941_abnormal_skin_development1.38604489
41MP0003283_abnormal_digestive_organ1.34277096
42MP0000013_abnormal_adipose_tissue1.34119898
43MP0000733_abnormal_muscle_development1.32782147
44MP0004215_abnormal_myocardial_fiber1.32063193
45MP0003191_abnormal_cellular_cholesterol1.30038199
46MP0002138_abnormal_hepatobiliary_system1.28235145
47MP0005330_cardiomyopathy1.24926527
48MP0002877_abnormal_melanocyte_morpholog1.24121587
49MP0002928_abnormal_bile_duct1.23974064
50MP0003300_gastrointestinal_ulcer1.23754091
51MP0005085_abnormal_gallbladder_physiolo1.22569376
52MP0002168_other_aberrant_phenotype1.22261642
53MP0003868_abnormal_feces_composition1.16831985
54MP0000467_abnormal_esophagus_morphology1.16435552
55MP0002796_impaired_skin_barrier1.14837147
56MP0005365_abnormal_bile_salt1.14627467
57MP0001243_abnormal_dermal_layer1.13948943
58MP0008775_abnormal_heart_ventricle1.13868225
59MP0002282_abnormal_trachea_morphology1.13173721
60MP0000383_abnormal_hair_follicle1.12925628
61MP0005084_abnormal_gallbladder_morpholo1.12700557
62MP0002108_abnormal_muscle_morphology1.12023890
63MP0001299_abnormal_eye_distance/1.11866575
64MP0000462_abnormal_digestive_system1.11090469
65MP0005220_abnormal_exocrine_pancreas1.10090083
66MP0002932_abnormal_joint_morphology1.09368077
67MP0000749_muscle_degeneration1.08380328
68MP0004036_abnormal_muscle_relaxation1.07004913
69MP0003937_abnormal_limbs/digits/tail_de1.05820871
70MP0000163_abnormal_cartilage_morphology1.03867974
71MP0005670_abnormal_white_adipose1.03566734
72MP0002128_abnormal_blood_circulation1.02600428
73MP0004782_abnormal_surfactant_physiolog1.02439210
74MP0000428_abnormal_craniofacial_morphol1.02006140
75MP0003935_abnormal_craniofacial_develop1.01983471
76MP0006138_congestive_heart_failure1.00605391
77MP0003755_abnormal_palate_morphology0.99101084
78MP0000516_abnormal_urinary_system0.98588484
79MP0005367_renal/urinary_system_phenotyp0.98588484
80MP0010234_abnormal_vibrissa_follicle0.96603614
81MP0004087_abnormal_muscle_fiber0.96602271
82MP0002115_abnormal_skeleton_extremities0.95115634
83MP0003045_fibrosis0.94993059
84MP0004084_abnormal_cardiac_muscle0.94487240
85MP0002269_muscular_atrophy0.94362444
86MP0001216_abnormal_epidermal_layer0.92399721
87MP0003453_abnormal_keratinocyte_physiol0.92052930
88MP0005501_abnormal_skin_physiology0.91851790
89MP0005375_adipose_tissue_phenotype0.91676527
90MP0001542_abnormal_bone_strength0.91176042
91MP0003890_abnormal_embryonic-extraembry0.90998446
92MP0002234_abnormal_pharynx_morphology0.90152584
93MP0002697_abnormal_eye_size0.90124921
94MP0010771_integument_phenotype0.90011011
95MP0001614_abnormal_blood_vessel0.89138221
96MP0010386_abnormal_urinary_bladder0.88508243
97MP0001915_intracranial_hemorrhage0.88490342
98MP0009780_abnormal_chondrocyte_physiolo0.88224617
99MP0002925_abnormal_cardiovascular_devel0.87082830
100MP0005076_abnormal_cell_differentiation0.86148743
101MP0002972_abnormal_cardiac_muscle0.85251508
102MP0004185_abnormal_adipocyte_glucose0.84753121
103MP0000432_abnormal_head_morphology0.84352021
104MP0002084_abnormal_developmental_patter0.82962725
105MP0000003_abnormal_adipose_tissue0.82877046
106MP0000427_abnormal_hair_cycle0.82582082
107MP0002113_abnormal_skeleton_development0.79978862
108MP0005620_abnormal_muscle_contractility0.79561081
109MP0008875_abnormal_xenobiotic_pharmacok0.78512662
110MP0005248_abnormal_Harderian_gland0.78005840
111MP0002086_abnormal_extraembryonic_tissu0.77966822
112MP0002233_abnormal_nose_morphology0.76439732
113MP0010630_abnormal_cardiac_muscle0.76371985
114MP0003984_embryonic_growth_retardation0.75380498
115MP0001175_abnormal_lung_morphology0.75050642
116MP0003122_maternal_imprinting0.75021919
117MP0002111_abnormal_tail_morphology0.74458393
118MP0005083_abnormal_biliary_tract0.73159229
119MP0002088_abnormal_embryonic_growth/wei0.72150654
120MP0004085_abnormal_heartbeat0.71475633
121MP0002092_abnormal_eye_morphology0.71039959
122MP0005332_abnormal_amino_acid0.70833156
123MP0002109_abnormal_limb_morphology0.70007362
124MP0003828_pulmonary_edema0.69814328
125MP0004197_abnormal_fetal_growth/weight/0.69651344
126MP0005595_abnormal_vascular_smooth0.68658260
127MP0005197_abnormal_uvea_morphology0.68161879
128MP0000762_abnormal_tongue_morphology0.67935348
129MP0001348_abnormal_lacrimal_gland0.67678882
130MP0005390_skeleton_phenotype0.67615228
131MP0003119_abnormal_digestive_system0.67550278
132MP0000627_abnormal_mammary_gland0.66755867
133MP0001849_ear_inflammation0.66707164
134MP0000266_abnormal_heart_morphology0.66673406
135MP0002116_abnormal_craniofacial_bone0.64997416
136MP0002249_abnormal_larynx_morphology0.64839385
137MP0005193_abnormal_anterior_eye0.64778321
138MP0004233_abnormal_muscle_weight0.64370787
139MP0002135_abnormal_kidney_morphology0.63846226
140MP0000049_abnormal_middle_ear0.63681463
141MP0002133_abnormal_respiratory_system0.63435869

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.86458246
2Premature rupture of membranes (HP:0001788)6.72869006
3Shallow orbits (HP:0000586)4.34717711
4Aortic dissection (HP:0002647)4.29898252
5Atrophic scars (HP:0001075)4.11968560
6Peritonitis (HP:0002586)3.95340256
7Aortic aneurysm (HP:0004942)3.88651269
8Cerebral aneurysm (HP:0004944)3.83258935
9Soft skin (HP:0000977)3.59636863
10Cervical subluxation (HP:0003308)3.53291801
11Dilatation of the ascending aorta (HP:0005111)3.40122833
12Ankle contracture (HP:0006466)3.39668911
13Broad metatarsal (HP:0001783)3.29658346
14Mitral valve prolapse (HP:0001634)3.28450185
15Fragile skin (HP:0001030)3.22354061
16Bladder diverticulum (HP:0000015)3.15415708
17Alopecia of scalp (HP:0002293)3.07143637
18Abnormality of dentin (HP:0010299)3.05397306
19Blue sclerae (HP:0000592)2.89163878
20Wormian bones (HP:0002645)2.79639004
21Popliteal pterygium (HP:0009756)2.78563804
22Biconcave vertebral bodies (HP:0004586)2.77155304
23Milia (HP:0001056)2.70342054
24Aneurysm (HP:0002617)2.69793715
25Ventricular tachycardia (HP:0004756)2.69631370
26Pterygium (HP:0001059)2.69082217
27Neonatal short-limb short stature (HP:0008921)2.68030742
28Genu recurvatum (HP:0002816)2.67932997
29Short nail (HP:0001799)2.59890274
30Vascular tortuosity (HP:0004948)2.55915516
31Deep venous thrombosis (HP:0002625)2.53986019
32Camptodactyly of toe (HP:0001836)2.51722348
33Onycholysis (HP:0001806)2.51560027
34Spinal rigidity (HP:0003306)2.47705322
35Natal tooth (HP:0000695)2.47191814
36Increased connective tissue (HP:0009025)2.45730910
37Wide anterior fontanel (HP:0000260)2.42369727
38Vertebral compression fractures (HP:0002953)2.41388449
39Ectopia lentis (HP:0001083)2.40307832
40Thin bony cortex (HP:0002753)2.39907859
41Wrist flexion contracture (HP:0001239)2.39153934
42Right ventricular cardiomyopathy (HP:0011663)2.36789721
43Short 4th metacarpal (HP:0010044)2.34313798
44Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.34313798
45Bowel diverticulosis (HP:0005222)2.33960393
46Abnormal delivery (HP:0001787)2.33778129
47Selective tooth agenesis (HP:0001592)2.31652344
48Plantar hyperkeratosis (HP:0007556)2.30281970
49Hyperextensible skin (HP:0000974)2.28846100
50Buphthalmos (HP:0000557)2.28096858
51Infantile muscular hypotonia (HP:0008947)2.23389208
52Lipoatrophy (HP:0100578)2.23320101
53Mesomelia (HP:0003027)2.21343895
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.21154710
55Osteolytic defects of the hand bones (HP:0009699)2.21154710
56Lymphangioma (HP:0100764)2.19997622
57Overgrowth (HP:0001548)2.17524052
58Focal segmental glomerulosclerosis (HP:0000097)2.16336067
59Ankyloglossia (HP:0010296)2.16260007
60Fragile nails (HP:0001808)2.13315768
61Coronal craniosynostosis (HP:0004440)2.13286710
62Abnormality of the acetabulum (HP:0003170)2.11452025
63Knee flexion contracture (HP:0006380)2.10799551
64Tibial bowing (HP:0002982)2.09064779
65Palpitations (HP:0001962)2.08887247
66Deviation of the hallux (HP:0010051)2.08643918
67Abnormal pancreas size (HP:0012094)2.07883576
68Ulnar bowing (HP:0003031)2.06071001
69Hallux valgus (HP:0001822)2.05683317
70Vascular calcification (HP:0004934)2.05388229
71Abnormality of the peritoneum (HP:0002585)2.02696443
72Elbow flexion contracture (HP:0002987)2.01480924
73Abnormality of the 4th metacarpal (HP:0010012)2.00716464
74Abnormality of oral frenula (HP:0000190)2.00018527
75Advanced eruption of teeth (HP:0006288)1.99516846
76Syringomyelia (HP:0003396)1.97344552
77Spinal cord lesions (HP:0100561)1.97344552
78Type 1 muscle fiber predominance (HP:0003803)1.96715804
79Nonimmune hydrops fetalis (HP:0001790)1.96204138
80Arterial tortuosity (HP:0005116)1.96013813
81Chondrocalcinosis (HP:0000934)1.95000838
82Mildly elevated creatine phosphokinase (HP:0008180)1.94497567
83Radial bowing (HP:0002986)1.94493266
84Cardiovascular calcification (HP:0011915)1.94479467
85Congenital glaucoma (HP:0001087)1.92251619
86Mitral regurgitation (HP:0001653)1.92124933
87Joint laxity (HP:0001388)1.91927630
88Bell-shaped thorax (HP:0001591)1.91826767
89Back pain (HP:0003418)1.90420226
90Bowed forearm bones (HP:0003956)1.90320843
91Bowing of the arm (HP:0006488)1.90320843
92Aplasia cutis congenita (HP:0001057)1.90014037
93Hyporeflexia of lower limbs (HP:0002600)1.89818763
94Hyperglycemia (HP:0003074)1.89718843
95Glomerulosclerosis (HP:0000096)1.89357026
96Femoral bowing (HP:0002980)1.89275402
97Mitral stenosis (HP:0001718)1.87132604
98Hypoalphalipoproteinemia (HP:0003233)1.86754644
99Abnormality of the nasal septum (HP:0000419)1.86653295
100Hepatoblastoma (HP:0002884)1.85352655
101Palmoplantar hyperkeratosis (HP:0000972)1.82154612
102Palmar hyperkeratosis (HP:0010765)1.82047180
103Atrial fibrillation (HP:0005110)1.81476445
104Abnormality of the calcaneus (HP:0008364)1.81114138
105Bradycardia (HP:0001662)1.80902767
106Broad long bones (HP:0005622)1.80634949
107Joint contractures involving the joints of the feet (HP:0100492)1.79307549
108Flexion contracture of toe (HP:0005830)1.79307549
109Subacute progressive viral hepatitis (HP:0006572)1.78726109
110Bundle branch block (HP:0011710)1.78393390
111Limited hip movement (HP:0008800)1.78246625
112Increased mean platelet volume (HP:0011877)1.77985079
113Turricephaly (HP:0000262)1.77609048
114Scapular winging (HP:0003691)1.77548449
115Abnormality of Sharpey fibers (HP:0100685)1.77430188
116Delayed gross motor development (HP:0002194)1.75951827
117Entropion (HP:0000621)1.75626210
118Broad face (HP:0000283)1.75006432
119Long toe (HP:0010511)1.74878980
120Aortic regurgitation (HP:0001659)1.74389670
121Abnormality of the intrinsic pathway (HP:0010989)1.73970898
122Increased density of long bones (HP:0006392)1.73427389
123Hypolipoproteinemia (HP:0010981)1.72097209
124Venous abnormality (HP:0002624)1.70714056
125Abnormality of the calf musculature (HP:0001430)1.70141966
126Vertebral arch anomaly (HP:0008438)1.69919724
127Broad ribs (HP:0000885)1.68799147
128Thick nail (HP:0001805)1.68292519
129Chorioretinal atrophy (HP:0000533)1.68240991
130Disproportionate tall stature (HP:0001519)1.68240143
131Venous insufficiency (HP:0005293)1.67533548
132Osteopenia (HP:0000938)1.67483736
133Xanthomatosis (HP:0000991)1.66829613
134Asymmetry of the thorax (HP:0001555)1.66631847
135Follicular hyperkeratosis (HP:0007502)1.66333892
136Tarsal synostosis (HP:0008368)1.66179384
137Striae distensae (HP:0001065)1.65342085
138Nail dystrophy (HP:0008404)1.64855379
139Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.63484719
140Hypoplastic labia majora (HP:0000059)1.63451011
141Conjugated hyperbilirubinemia (HP:0002908)1.62875329
142Reduced subcutaneous adipose tissue (HP:0003758)1.61124955
143Abnormal foot bone ossification (HP:0010675)1.60528461
144Hypoplasia of dental enamel (HP:0006297)1.60514377
145Abnormality of carpal bone ossification (HP:0006257)1.60303610
146Pulmonic stenosis (HP:0001642)1.59850568
147Spondylolisthesis (HP:0003302)1.59435089
148Insulin resistance (HP:0000855)1.59215153
149Thin skin (HP:0000963)1.57614862
150Abnormality of the labia majora (HP:0012881)1.56566540
151Proximal tubulopathy (HP:0000114)1.53830891
152Trismus (HP:0000211)1.53245737
153Abnormality of the distal phalanges of the toes (HP:0010182)1.48398983
154Abnormality of the common coagulation pathway (HP:0010990)1.48283435
155Glucose intolerance (HP:0000833)1.47665243
156Short chin (HP:0000331)1.47354806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.04032464
2TTN3.87268279
3DDR23.32405516
4TRIB33.25127548
5MST43.23896235
6PDGFRA3.21768324
7EPHA22.84964539
8EPHB22.32400853
9PBK2.32142910
10LATS22.28804090
11PKN22.24289762
12PTK22.17016720
13EIF2AK32.15975318
14RIPK12.13474326
15FRK2.11629174
16MAP3K122.05000480
17PTK62.02580604
18SIK11.99084039
19FER1.94522078
20STK38L1.92188205
21PAK21.89274142
22STK391.82487831
23ERN11.79741713
24PAK31.78716254
25PAK41.74472401
26NEK91.68448730
27MET1.59033446
28STK31.47749623
29TGFBR21.46747149
30EPHA31.39608370
31LRRK21.38661737
32TIE11.37009376
33LMTK21.36380196
34DMPK1.31631840
35MYLK1.27972560
36KDR1.27084231
37AKT31.25870770
38TESK11.25243202
39BRSK21.24940277
40PIK3CG1.23540869
41TRPM71.23426562
42PIK3CA1.21912973
43WNK41.21851970
44FGFR41.17794582
45EIF2AK11.17544816
46NUAK11.14374550
47RPS6KA41.14004508
48FGFR11.13146395
49PDGFRB1.13143597
50BMX1.13110918
51FGFR21.12160474
52PDK21.10465976
53TGFBR11.10438454
54* MTOR1.08612799
55PNCK1.05647115
56STK241.03947477
57TSSK61.01005341
58ERBB30.98689312
59PTK2B0.98009432
60LIMK10.96230123
61TRIM280.95071129
62ERBB40.92701241
63ROCK10.92206172
64PRKCE0.90629744
65CDK60.87936115
66CDK80.87217592
67NEK10.87014846
68PRKD30.86163759
69MAP3K100.83251770
70TTK0.82134808
71INSRR0.80360285
72ILK0.80001333
73FLT30.79461585
74TNIK0.77787574
75DYRK1B0.77438528
76MAP3K30.76836709
77GRK10.75585696
78CDC42BPA0.73226693
79MAP2K10.72582326
80ZAK0.70333134
81MST1R0.68306812
82STK100.68226378
83NLK0.68130649
84CAMK1D0.67626657
85BCR0.67370577
86BMPR1B0.66374334
87ERBB20.66117177
88INSR0.62314418
89CDK120.61919570
90CAMK2D0.60888034
91PLK30.60075330
92MKNK20.58299005
93MAPKAPK30.56490254
94PRKD10.55913568
95ABL20.55854736
96WNK30.55390403
97EPHB10.53995507
98WNK10.53111498
99WEE10.52292554
100GSK3A0.51442007
101MAP3K80.49672016
102PRKAA20.48926213
103CDK90.48787740
104PRKD20.48656268
105BUB10.48051534
106NTRK10.46473383
107SCYL20.46116820
108MUSK0.43491000
109RPS6KB20.43259000
110PASK0.43070734
111PRKCH0.41259255
112BRD40.41228834
113FGFR30.39849613
114MELK0.39619580
115IGF1R0.38777787
116RET0.38444877
117AKT20.38387187
118CAMK1G0.38022678
119SRC0.37236944
120PRKG20.37023888
121DAPK30.36070963
122ICK0.35695156
123MOS0.34584397
124NEK20.33397178
125ROCK20.30921682
126PRKCI0.30785858
127MAP2K30.30766127
128MAP3K20.30479910
129PLK10.29418346
130EGFR0.29253865
131ADRBK10.29099916
132MAP2K20.28595659
133OXSR10.28578063
134STK380.27855949
135MAPK150.27447643
136JAK10.25606482
137MAPK10.25380398
138ABL10.25015604
139AURKB0.24983979

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.37425687
2Focal adhesion_Homo sapiens_hsa045102.57946347
3Adherens junction_Homo sapiens_hsa045202.30134125
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.29795277
5Bladder cancer_Homo sapiens_hsa052192.10730469
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.08645660
7Proteoglycans in cancer_Homo sapiens_hsa052051.95103269
8Tryptophan metabolism_Homo sapiens_hsa003801.89404376
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.88963918
10Complement and coagulation cascades_Homo sapiens_hsa046101.86448981
11Small cell lung cancer_Homo sapiens_hsa052221.85505107
12Hippo signaling pathway_Homo sapiens_hsa043901.80600475
13Nitrogen metabolism_Homo sapiens_hsa009101.79054523
14Fatty acid degradation_Homo sapiens_hsa000711.74595050
15Protein digestion and absorption_Homo sapiens_hsa049741.69615159
16Amoebiasis_Homo sapiens_hsa051461.65352288
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64642562
18Vitamin B6 metabolism_Homo sapiens_hsa007501.64449138
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.64133543
20TGF-beta signaling pathway_Homo sapiens_hsa043501.62714396
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.54700921
22Dilated cardiomyopathy_Homo sapiens_hsa054141.52970803
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.50786016
24Selenocompound metabolism_Homo sapiens_hsa004501.49718927
25MicroRNAs in cancer_Homo sapiens_hsa052061.43498705
26Basal cell carcinoma_Homo sapiens_hsa052171.42153685
27Lysine degradation_Homo sapiens_hsa003101.37132177
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36424345
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.34926944
30Non-homologous end-joining_Homo sapiens_hsa034501.34801742
31Tight junction_Homo sapiens_hsa045301.31107573
32Arginine biosynthesis_Homo sapiens_hsa002201.30125745
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29083265
34Sulfur metabolism_Homo sapiens_hsa009201.28639017
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26602592
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21488521
37PI3K-Akt signaling pathway_Homo sapiens_hsa041511.20729038
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19813239
39PPAR signaling pathway_Homo sapiens_hsa033201.17115553
40Chemical carcinogenesis_Homo sapiens_hsa052041.17042824
41Hedgehog signaling pathway_Homo sapiens_hsa043401.15614319
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13681677
43Bile secretion_Homo sapiens_hsa049761.11470660
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11300493
45Fatty acid metabolism_Homo sapiens_hsa012121.10834541
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09148212
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.08387451
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.06986468
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04903297
50Butanoate metabolism_Homo sapiens_hsa006501.04155011
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03310697
52Prostate cancer_Homo sapiens_hsa052151.02684782
53Melanoma_Homo sapiens_hsa052181.01494415
54Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00575439
55Fatty acid biosynthesis_Homo sapiens_hsa000610.99187490
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98074227
57p53 signaling pathway_Homo sapiens_hsa041150.95745889
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95596789
59Chronic myeloid leukemia_Homo sapiens_hsa052200.94642509
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93499422
61Starch and sucrose metabolism_Homo sapiens_hsa005000.89311644
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.88831066
63Protein export_Homo sapiens_hsa030600.86238061
64Circadian rhythm_Homo sapiens_hsa047100.85972761
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83088649
66Retinol metabolism_Homo sapiens_hsa008300.82091066
67Malaria_Homo sapiens_hsa051440.81668716
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81463512
69Peroxisome_Homo sapiens_hsa041460.80326741
70Sphingolipid metabolism_Homo sapiens_hsa006000.74991226
71Rap1 signaling pathway_Homo sapiens_hsa040150.74713980
72Propanoate metabolism_Homo sapiens_hsa006400.74000074
73Pathways in cancer_Homo sapiens_hsa052000.73639193
74Arginine and proline metabolism_Homo sapiens_hsa003300.73624134
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72697293
76One carbon pool by folate_Homo sapiens_hsa006700.72461055
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.70972518
78Insulin resistance_Homo sapiens_hsa049310.69096727
79Folate biosynthesis_Homo sapiens_hsa007900.68894505
80Viral myocarditis_Homo sapiens_hsa054160.68223964
81Caffeine metabolism_Homo sapiens_hsa002320.68067530
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67224301
83Phenylalanine metabolism_Homo sapiens_hsa003600.66475513
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65526028
85Fatty acid elongation_Homo sapiens_hsa000620.63567176
86N-Glycan biosynthesis_Homo sapiens_hsa005100.63522088
87Pancreatic cancer_Homo sapiens_hsa052120.62902214
88Thyroid cancer_Homo sapiens_hsa052160.59524443
89Pyruvate metabolism_Homo sapiens_hsa006200.59223754
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57929794
91Tyrosine metabolism_Homo sapiens_hsa003500.57270739
92Glutathione metabolism_Homo sapiens_hsa004800.56953317
93Vitamin digestion and absorption_Homo sapiens_hsa049770.56724738
94Carbon metabolism_Homo sapiens_hsa012000.56134198
95Glioma_Homo sapiens_hsa052140.55624531
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54225846
97Histidine metabolism_Homo sapiens_hsa003400.54134225
98Thyroid hormone synthesis_Homo sapiens_hsa049180.53904626
99Fat digestion and absorption_Homo sapiens_hsa049750.53409615
100Wnt signaling pathway_Homo sapiens_hsa043100.52777656
101Axon guidance_Homo sapiens_hsa043600.52417497
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.51909167
103Renin-angiotensin system_Homo sapiens_hsa046140.51791004
104Ovarian steroidogenesis_Homo sapiens_hsa049130.50178303
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50046729
106Glycerolipid metabolism_Homo sapiens_hsa005610.48629410
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48427432
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48023974
109RNA transport_Homo sapiens_hsa030130.47322201
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47308671
111Endometrial cancer_Homo sapiens_hsa052130.47008305
112Platelet activation_Homo sapiens_hsa046110.46340077
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.46121660
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45549108
115Biosynthesis of amino acids_Homo sapiens_hsa012300.45474626
116HTLV-I infection_Homo sapiens_hsa051660.45124906
117Shigellosis_Homo sapiens_hsa051310.44987859
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44753830
119AMPK signaling pathway_Homo sapiens_hsa041520.43079117
120Renin secretion_Homo sapiens_hsa049240.42654986
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41818711
122Inositol phosphate metabolism_Homo sapiens_hsa005620.41343620
123Glucagon signaling pathway_Homo sapiens_hsa049220.40192374
124Renal cell carcinoma_Homo sapiens_hsa052110.39490539
125beta-Alanine metabolism_Homo sapiens_hsa004100.38953316

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