PHLDB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of histone deacetylation (GO:0031065)4.62702572
2cellular response to ATP (GO:0071318)4.40238593
3negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.37822884
4regulation of apoptotic process involved in morphogenesis (GO:1902337)3.92890042
5GDP-mannose metabolic process (GO:0019673)3.68130567
6regulation of histone deacetylation (GO:0031063)3.66182200
7positive regulation of triglyceride biosynthetic process (GO:0010867)3.66150518
8positive regulation of protein deacetylation (GO:0090312)3.61226085
9phosphatidylglycerol biosynthetic process (GO:0006655)3.59865286
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.54460326
11establishment of skin barrier (GO:0061436)3.41430670
12ribosomal small subunit assembly (GO:0000028)3.32601451
13negative regulation of phagocytosis (GO:0050765)3.30487647
14behavioral response to nicotine (GO:0035095)3.29710281
15positive regulation of fatty acid beta-oxidation (GO:0032000)3.29102648
16DNA deamination (GO:0045006)3.26426647
17positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.25853532
18indole-containing compound catabolic process (GO:0042436)3.18169726
19indolalkylamine catabolic process (GO:0046218)3.18169726
20tryptophan catabolic process (GO:0006569)3.18169726
21regulation of superoxide anion generation (GO:0032928)3.14677919
22arginine metabolic process (GO:0006525)3.13106040
23L-fucose catabolic process (GO:0042355)3.10948864
24fucose catabolic process (GO:0019317)3.10948864
25L-fucose metabolic process (GO:0042354)3.10948864
26positive regulation of fatty acid oxidation (GO:0046321)3.10105334
27tRNA modification (GO:0006400)3.09725994
28regulation of water loss via skin (GO:0033561)3.09472539
29tRNA methylation (GO:0030488)3.07655725
30response to misfolded protein (GO:0051788)3.06713622
31positive regulation of keratinocyte differentiation (GO:0045618)3.06438366
32positive regulation of lymphocyte apoptotic process (GO:0070230)3.06212592
33definitive hemopoiesis (GO:0060216)3.05536591
34regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.04577794
35positive regulation of CREB transcription factor activity (GO:0032793)3.04559038
36misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.03598886
37cellular ketone body metabolic process (GO:0046950)3.01291080
38positive regulation of gamma-delta T cell activation (GO:0046645)2.99368804
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98264687
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98264687
41positive regulation of fatty acid transport (GO:2000193)2.98238038
42dendritic cell chemotaxis (GO:0002407)2.93621313
43positive regulation of icosanoid secretion (GO:0032305)2.93198054
44regulation of hypersensitivity (GO:0002883)2.93112710
45metallo-sulfur cluster assembly (GO:0031163)2.92181735
46iron-sulfur cluster assembly (GO:0016226)2.92181735
47lipoxygenase pathway (GO:0019372)2.91695569
48positive regulation of mast cell activation involved in immune response (GO:0033008)2.91456304
49positive regulation of mast cell degranulation (GO:0043306)2.91456304
50positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.88755761
51regulation of fatty acid beta-oxidation (GO:0031998)2.88727535
52positive regulation by host of viral transcription (GO:0043923)2.87423237
53nucleoside transmembrane transport (GO:1901642)2.84571495
54tryptophan metabolic process (GO:0006568)2.84537170
55positive regulation of triglyceride metabolic process (GO:0090208)2.83928284
56regulation of triglyceride catabolic process (GO:0010896)2.83850157
57aromatic amino acid family catabolic process (GO:0009074)2.83416377
58dendritic cell migration (GO:0036336)2.79963341
59negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.78071517
60T cell migration (GO:0072678)2.77223169
61rRNA transcription (GO:0009303)2.77109909
62regulation of triglyceride biosynthetic process (GO:0010866)2.74513260
63positive regulation of T cell apoptotic process (GO:0070234)2.73421472
64positive regulation of mast cell activation (GO:0033005)2.72552997
65V(D)J recombination (GO:0033151)2.71244625
66negative regulation of cAMP-mediated signaling (GO:0043951)2.68577744
67regulation of nuclear cell cycle DNA replication (GO:0033262)2.67971759
68regulation of defense response to virus by host (GO:0050691)2.67836613
69positive regulation of protein kinase C signaling (GO:0090037)2.67628154
70positive regulation of B cell differentiation (GO:0045579)2.67597026
71molting cycle (GO:0042303)2.67088202
72hair cycle (GO:0042633)2.67088202
73hepatocyte apoptotic process (GO:0097284)2.66651051
74platelet dense granule organization (GO:0060155)2.64690028
75indolalkylamine metabolic process (GO:0006586)2.63909871
76drug catabolic process (GO:0042737)2.62692789
77axoneme assembly (GO:0035082)2.61942823
78amine catabolic process (GO:0009310)2.61572529
79cellular biogenic amine catabolic process (GO:0042402)2.61572529
80regulation of cell proliferation involved in kidney development (GO:1901722)2.61486180
81antigen processing and presentation of endogenous antigen (GO:0019883)2.60840992
82opioid receptor signaling pathway (GO:0038003)2.59674600
83positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.58056319
84detection of bacterium (GO:0016045)2.56564933
85mannose metabolic process (GO:0006013)2.56473360
86detection of other organism (GO:0098543)2.56357905
87positive regulation of defense response to virus by host (GO:0002230)2.56346980
88ketone body metabolic process (GO:1902224)2.56043580
89keratinocyte development (GO:0003334)2.54385353
90mannosylation (GO:0097502)2.52826214
91leukocyte aggregation (GO:0070486)2.52622629
92regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.52413878
93negative regulation of cell size (GO:0045792)2.51083347
94regulation of mast cell activation (GO:0033003)2.50958526
95regulation of mast cell degranulation (GO:0043304)2.50024158
96modulation by virus of host process (GO:0019054)2.49496076
97negative regulation of viral release from host cell (GO:1902187)2.49200925
98regulation of viral release from host cell (GO:1902186)2.49178240
99snRNA transcription (GO:0009301)2.46556143
100tolerance induction (GO:0002507)2.45662459
101kynurenine metabolic process (GO:0070189)2.44893103
102erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.44318859
103L-phenylalanine catabolic process (GO:0006559)2.44318859
104B cell receptor signaling pathway (GO:0050853)2.44296834
105positive regulation of megakaryocyte differentiation (GO:0045654)2.44102811
106DNA topological change (GO:0006265)2.43219288
107erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.43055921
108L-phenylalanine metabolic process (GO:0006558)2.43055921
109oxidative demethylation (GO:0070989)2.42977005
110interferon-gamma production (GO:0032609)2.42278352
111response to peptidoglycan (GO:0032494)2.42114924
112leukotriene biosynthetic process (GO:0019370)2.41972195
113regulation of endothelial cell chemotaxis (GO:2001026)2.41601294
114positive regulation of epidermal cell differentiation (GO:0045606)2.41251105
115aromatic amino acid family metabolic process (GO:0009072)2.39883534
116regulation of hippo signaling (GO:0035330)2.39642813
117desmosome organization (GO:0002934)2.38501080
118regulation of mast cell activation involved in immune response (GO:0033006)2.38412709
119superoxide anion generation (GO:0042554)2.38361470
120autophagic vacuole fusion (GO:0000046)2.36432776
121positive regulation of prostaglandin secretion (GO:0032308)2.36319826
122NAD biosynthetic process (GO:0009435)2.36225311
123germinal center formation (GO:0002467)2.35948614
124exogenous drug catabolic process (GO:0042738)2.35684823
125cellular response to exogenous dsRNA (GO:0071360)2.34760515
126tyrosine phosphorylation of STAT protein (GO:0007260)2.33480928
127mesonephros development (GO:0001823)2.33223138
128regulation of protein deacetylation (GO:0090311)2.32773856
129DNA synthesis involved in DNA repair (GO:0000731)2.32335088
130DNA ligation (GO:0006266)2.32137863
131flavonoid metabolic process (GO:0009812)2.30190220
132cellular extravasation (GO:0045123)2.30158844
133fucosylation (GO:0036065)2.29350765
134production of molecular mediator involved in inflammatory response (GO:0002532)2.29349113
135regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.29187203
136peptidyl-glutamic acid carboxylation (GO:0017187)2.28612669
137protein carboxylation (GO:0018214)2.28612669
138organic cation transport (GO:0015695)2.28498091
139regulation of fatty acid transport (GO:2000191)2.27679517
140epithelial cilium movement (GO:0003351)2.27152324
141pyrimidine dimer repair (GO:0006290)2.27080947
142telomere maintenance via semi-conservative replication (GO:0032201)2.26746328
143multicellular organismal water homeostasis (GO:0050891)2.25956832
144folic acid metabolic process (GO:0046655)2.25873728
145purine deoxyribonucleotide catabolic process (GO:0009155)2.25614489
146regulation of B cell differentiation (GO:0045577)2.23273436
147response to muramyl dipeptide (GO:0032495)2.21898478
148maturation of SSU-rRNA (GO:0030490)2.21406454
149CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.19520481
150neutrophil activation (GO:0042119)2.18750877
151response to protozoan (GO:0001562)2.18274135
152regulation of gamma-delta T cell activation (GO:0046643)2.15886974
153sphingoid metabolic process (GO:0046519)2.13546317
154leukotriene metabolic process (GO:0006691)2.12769271
155negative regulation of DNA-dependent DNA replication (GO:2000104)2.11699689
156ribosomal small subunit biogenesis (GO:0042274)2.10893371
157telomere maintenance via recombination (GO:0000722)2.10391894
158positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.09980171
159T cell lineage commitment (GO:0002360)2.09743637
160natural killer cell activation involved in immune response (GO:0002323)2.09719206
161base-excision repair, AP site formation (GO:0006285)2.09049933
162negative regulation of telomere maintenance (GO:0032205)2.08902626
163interferon-gamma secretion (GO:0072643)2.07829193
164keratinization (GO:0031424)2.05921930
165T cell homeostasis (GO:0043029)2.04943138
166regulation of double-strand break repair via homologous recombination (GO:0010569)2.04114637
167defense response to protozoan (GO:0042832)2.03977951
168regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.03167222
169sphingosine metabolic process (GO:0006670)2.02790084
170regulation of somitogenesis (GO:0014807)2.02502068
171negative regulation of mast cell activation (GO:0033004)2.02471707
172modulation by symbiont of host cellular process (GO:0044068)2.00395439
173regulation of superoxide metabolic process (GO:0090322)2.00249892
174myeloid dendritic cell activation (GO:0001773)1.99426722
175regulation of interleukin-8 secretion (GO:2000482)1.98514258
176mitotic recombination (GO:0006312)1.98416256
177lymphocyte homeostasis (GO:0002260)1.98406389
178positive regulation of immunoglobulin production (GO:0002639)1.98303567
179telomere maintenance via telomere lengthening (GO:0010833)1.98196700
180regulation of chemokine secretion (GO:0090196)1.97856701
181positive regulation of B cell activation (GO:0050871)1.97552461
182viral mRNA export from host cell nucleus (GO:0046784)1.96526810
183regulation of telomere maintenance via telomerase (GO:0032210)1.95981069
184regulation of myeloid leukocyte mediated immunity (GO:0002886)1.95768195
185modulation by host of viral transcription (GO:0043921)1.95691687
186modulation by host of symbiont transcription (GO:0052472)1.95691687
187bone remodeling (GO:0046849)1.95360485
188regulation of B cell receptor signaling pathway (GO:0050855)1.94988535
189granulocyte activation (GO:0036230)1.94910822
190DNA strand elongation (GO:0022616)1.94634125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.61151970
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.46911332
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.37750412
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.91602384
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.49298192
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.35257512
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.98575937
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.98105133
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.85005964
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78088453
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.58950068
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.48990723
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.47178557
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.46008379
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.42215613
16LXR_22292898_ChIP-Seq_THP-1_Human2.33383695
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32790050
18P68_20966046_ChIP-Seq_HELA_Human2.31365236
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.30171326
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28641357
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25672402
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.24330627
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.20957463
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20747615
25SCL_19346495_ChIP-Seq_HPC-7_Human2.17985541
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.16819232
27BCL6_27268052_Chip-Seq_Bcells_Human2.14532645
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13051143
29* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05826644
30ELF1_20517297_ChIP-Seq_JURKAT_Human2.04609830
31VDR_21846776_ChIP-Seq_THP-1_Human2.03530592
32BCOR_27268052_Chip-Seq_Bcells_Human2.02006667
33MYC_22102868_ChIP-Seq_BL_Human1.99943793
34* E2F1_20622854_ChIP-Seq_HELA_Human1.97083377
35PHF8_20622854_ChIP-Seq_HELA_Human1.92461215
36* TET1_21451524_ChIP-Seq_MESCs_Mouse1.91513073
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.90281029
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87493321
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81003512
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80749194
41SPI1_23547873_ChIP-Seq_NB4_Human1.79032358
42RACK7_27058665_Chip-Seq_MCF-7_Human1.75835637
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.71470612
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.71445247
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.70142537
46CIITA_25753668_ChIP-Seq_RAJI_Human1.67618393
47RAC3_21632823_ChIP-Seq_H3396_Human1.67202164
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.66813776
49YY1_22570637_ChIP-Seq_MALME-3M_Human1.65944813
50CTCF_27219007_Chip-Seq_Bcells_Human1.64390344
51ERA_21632823_ChIP-Seq_H3396_Human1.63977530
52CTCF_20526341_ChIP-Seq_ESCs_Human1.63654255
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.62865460
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60876604
55* MYB_26560356_Chip-Seq_TH2_Human1.60319166
56MYB_26560356_Chip-Seq_TH1_Human1.59651048
57SMC4_20622854_ChIP-Seq_HELA_Human1.59115881
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59085816
59* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57142804
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56475614
61* TP63_22573176_ChIP-Seq_HFKS_Human1.56054729
62VDR_23849224_ChIP-Seq_CD4+_Human1.55403984
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.54025927
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54021445
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54012764
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53596513
67FOXP3_21729870_ChIP-Seq_TREG_Human1.53516900
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52542773
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51720488
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51674926
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.50895685
72RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50561424
73FOXP1_21924763_ChIP-Seq_HESCs_Human1.50482096
74CTCF_26484167_Chip-Seq_Bcells_Mouse1.49679104
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.49641946
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.49533470
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49504313
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.49425098
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49372448
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.49150413
81* RARB_24833708_ChIP-Seq_LIVER_Mouse1.47679866
82* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47381719
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.47337822
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46434893
85RUNX_20019798_ChIP-Seq_JUKART_Human1.45964877
86TP53_22127205_ChIP-Seq_IMR90_Human1.44999097
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.44934345
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42427324
89* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41694159
90* MAF_26560356_Chip-Seq_TH1_Human1.41652093
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40538840
92RXRA_24833708_ChIP-Seq_LIVER_Mouse1.37730188
93SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37455016
94GABP_19822575_ChIP-Seq_HepG2_Human1.37411831
95ZNF263_19887448_ChIP-Seq_K562_Human1.36727328
96SA1_27219007_Chip-Seq_Bcells_Human1.36091147
97MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35590433
98ETS1_20019798_ChIP-Seq_JURKAT_Human1.34909129
99VDR_24763502_ChIP-Seq_THP-1_Human1.34212948
100RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33647986
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33550166
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33375550
103KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32430799
104P300_27268052_Chip-Seq_Bcells_Human1.30693049
105CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30055720
106RXR_22158963_ChIP-Seq_LIVER_Mouse1.28932229
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28653135
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27905027
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.27184643
110MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26588250
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25597203
112MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25554003
113NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24932164
114* RARA_24833708_ChIP-Seq_LIVER_Mouse1.24703745
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24330735
116EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23794101
117UTX_26944678_Chip-Seq_JUKART_Human1.22981133
118ELK1_19687146_ChIP-ChIP_HELA_Human1.21476721
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20240406
120BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19360777
121CTCF_21964334_ChIP-Seq_BJAB-B_Human1.18985668
122CREB1_26743006_Chip-Seq_LNCaP_Human1.18898224
123MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18684517
124ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17537988
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16489274
126STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15528345
127* OCT4_20526341_ChIP-Seq_ESCs_Human1.15272766
128DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15051459
129KDM2B_26808549_Chip-Seq_DND41_Human1.13690368
130RUNX1_27514584_Chip-Seq_MCF-7_Human1.13634613
131CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13250935
132TAF2_19829295_ChIP-Seq_ESCs_Human1.12161955
133* SRF_21415370_ChIP-Seq_HL-1_Mouse1.12045573
134KDM5A_27292631_Chip-Seq_BREAST_Human1.11787677
135CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10987988
136YY1_21170310_ChIP-Seq_MESCs_Mouse1.10702162
137FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09361965
138NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07987090
139CTCF_21964334_Chip-Seq_Bcells_Human1.07890325
140P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07775345
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07232912
142* NANOG_20526341_ChIP-Seq_ESCs_Human1.07010248
143GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06440023
144MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06154195
145OCT4_19829295_ChIP-Seq_ESCs_Human1.05960418
146MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05878256
147* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05553222
148EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05460592
149BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05198688
150* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04828555
151ZNF274_21170338_ChIP-Seq_K562_Hela1.03082991
152UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02653928
153EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02391066
154* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02286385
155RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02276779
156HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02161853
157RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01568857
158GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01223201
159DCP1A_22483619_ChIP-Seq_HELA_Human0.99116143
160PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98484844
161XRN2_22483619_ChIP-Seq_HELA_Human0.97933059
162BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97237481
163RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96890620
164CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96670072
165MAF_26560356_Chip-Seq_TH2_Human0.95830152
166NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92829021
167TTF2_22483619_ChIP-Seq_HELA_Human0.91940807
168SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90446287
169TCF7_22412390_ChIP-Seq_EML_Mouse0.90038660
170MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89360831
171E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88557171
172CDX2_20551321_ChIP-Seq_CACO-2_Human0.86651316
173YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86231457
174GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85463249
175CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83816885
176NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82521511
177PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82317698

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004381_abnormal_hair_follicle3.32781428
2MP0000566_synostosis3.11521581
3MP0008875_abnormal_xenobiotic_pharmacok3.02387629
4MP0002876_abnormal_thyroid_physiology2.30548247
5MP0001986_abnormal_taste_sensitivity2.22251126
6MP0005387_immune_system_phenotype2.16985142
7MP0001790_abnormal_immune_system2.16985142
8MP0001800_abnormal_humoral_immune2.14707274
9MP0005360_urolithiasis2.14403136
10MP0003941_abnormal_skin_development2.13219223
11MP0005365_abnormal_bile_salt2.12068922
12MP0000678_abnormal_parathyroid_gland2.10369306
13MP0002139_abnormal_hepatobiliary_system2.09534107
14MP0003763_abnormal_thymus_physiology2.09216616
15MP0001835_abnormal_antigen_presentation2.07089176
16MP0005451_abnormal_body_composition2.07078270
17MP0002396_abnormal_hematopoietic_system2.06123270
18MP0000465_gastrointestinal_hemorrhage1.97797078
19MP0003693_abnormal_embryo_hatching1.94371115
20MP0004043_abnormal_pH_regulation1.92599001
21MP0003436_decreased_susceptibility_to1.88484037
22MP0002160_abnormal_reproductive_system1.85881592
23MP0003111_abnormal_nucleus_morphology1.82745774
24MP0002132_abnormal_respiratory_system1.82482974
25MP0010094_abnormal_chromosome_stability1.82473043
26MP0003878_abnormal_ear_physiology1.82182046
27MP0005377_hearing/vestibular/ear_phenot1.82182046
28MP0002148_abnormal_hypersensitivity_rea1.81480444
29MP0005075_abnormal_melanosome_morpholog1.81387205
30MP0005671_abnormal_response_to1.81350943
31MP0004264_abnormal_extraembryonic_tissu1.80913255
32MP0009785_altered_susceptibility_to1.80600787
33MP0008007_abnormal_cellular_replicative1.79555743
34MP0002452_abnormal_antigen_presenting1.77889084
35MP0002796_impaired_skin_barrier1.72795912
36MP0000383_abnormal_hair_follicle1.72233834
37MP0004947_skin_inflammation1.72152747
38MP0005083_abnormal_biliary_tract1.71720020
39MP0003195_calcinosis1.70531422
40MP0001873_stomach_inflammation1.69943170
41MP0010155_abnormal_intestine_physiology1.67825821
42MP0002249_abnormal_larynx_morphology1.66570959
43MP0003011_delayed_dark_adaptation1.66268267
44MP0002420_abnormal_adaptive_immunity1.63794606
45MP0002723_abnormal_immune_serum1.63318294
46MP0002098_abnormal_vibrissa_morphology1.62668761
47MP0005000_abnormal_immune_tolerance1.62205953
48MP0001819_abnormal_immune_cell1.61113630
49MP0000470_abnormal_stomach_morphology1.57717943
50MP0009333_abnormal_splenocyte_physiolog1.57669198
51MP0000685_abnormal_immune_system1.56079582
52MP0002398_abnormal_bone_marrow1.55106027
53MP0000015_abnormal_ear_pigmentation1.53273872
54MP0002419_abnormal_innate_immunity1.52602481
55MP0002060_abnormal_skin_morphology1.52034914
56MP0004133_heterotaxia1.51528454
57MP0006292_abnormal_olfactory_placode1.51224760
58MP0008058_abnormal_DNA_repair1.50644612
59MP0000490_abnormal_crypts_of1.49591874
60MP0005464_abnormal_platelet_physiology1.49133812
61MP0005025_abnormal_response_to1.48744086
62MP0005501_abnormal_skin_physiology1.46604059
63MP0003646_muscle_fatigue1.45815100
64MP0002095_abnormal_skin_pigmentation1.44466948
65MP0009384_cardiac_valve_regurgitation1.41352380
66MP0000716_abnormal_immune_system1.40413035
67MP0008995_early_reproductive_senescence1.40144331
68MP0002722_abnormal_immune_system1.39971652
69MP0000689_abnormal_spleen_morphology1.39780323
70MP0002277_abnormal_respiratory_mucosa1.39336750
71MP0004808_abnormal_hematopoietic_stem1.38889441
72MP0000371_diluted_coat_color1.37889339
73MP0002254_reproductive_system_inflammat1.36416811
74MP0001216_abnormal_epidermal_layer1.36379807
75MP0000372_irregular_coat_pigmentation1.35434061
76MP0005171_absent_coat_pigmentation1.35090516
77MP0000538_abnormal_urinary_bladder1.34257660
78MP0002405_respiratory_system_inflammati1.32027357
79MP0009278_abnormal_bone_marrow1.31300691
80MP0003453_abnormal_keratinocyte_physiol1.30180778
81MP0003724_increased_susceptibility_to1.30071240
82MP0000579_abnormal_nail_morphology1.28509611
83MP0005332_abnormal_amino_acid1.27890693
84MP0005174_abnormal_tail_pigmentation1.27841037
85MP0002653_abnormal_ependyma_morphology1.25987338
86MP0005389_reproductive_system_phenotype1.25833655
87MP0004019_abnormal_vitamin_homeostasis1.25757108
88MP0000703_abnormal_thymus_morphology1.23942704
89MP0008872_abnormal_physiological_respon1.22780529
90MP0003786_premature_aging1.21660893
91MP0002837_dystrophic_cardiac_calcinosis1.20491680
92MP0002429_abnormal_blood_cell1.20421830
93MP0003077_abnormal_cell_cycle1.20392947
94MP0008057_abnormal_DNA_replication1.16355478
95MP0005397_hematopoietic_system_phenotyp1.14230175
96MP0001545_abnormal_hematopoietic_system1.14230175
97MP0010329_abnormal_lipoprotein_level1.14030547
98MP0005408_hypopigmentation1.13158850
99MP0001845_abnormal_inflammatory_respons1.12182040
100MP0005085_abnormal_gallbladder_physiolo1.11325984
101MP0003806_abnormal_nucleotide_metabolis1.11109105
102MP0001348_abnormal_lacrimal_gland1.10771161
103MP0001270_distended_abdomen1.10032804
104MP0000647_abnormal_sebaceous_gland1.09721781
105MP0009643_abnormal_urine_homeostasis1.09362192
106MP0002163_abnormal_gland_morphology1.08879738
107MP0002136_abnormal_kidney_physiology1.08538354
108MP0008961_abnormal_basal_metabolism1.06763540
109MP0005410_abnormal_fertilization1.06042754
110MP0001346_abnormal_lacrimal_gland1.05790128
111MP0000003_abnormal_adipose_tissue1.05661791
112MP0001502_abnormal_circadian_rhythm1.04484992
113MP0002075_abnormal_coat/hair_pigmentati1.04187501
114MP0002693_abnormal_pancreas_physiology1.03332977
115MP0005645_abnormal_hypothalamus_physiol1.02632232
116MP0001764_abnormal_homeostasis1.00808280
117MP0003252_abnormal_bile_duct1.00624024
118MP0000858_altered_metastatic_potential0.99652379
119MP0002933_joint_inflammation0.98610037
120MP0000377_abnormal_hair_follicle0.96788335
121MP0003191_abnormal_cellular_cholesterol0.95553879
122MP0001968_abnormal_touch/_nociception0.95409338
123MP0001944_abnormal_pancreas_morphology0.94744196
124MP0005220_abnormal_exocrine_pancreas0.93237033
125MP0009931_abnormal_skin_appearance0.93040610
126MP0000613_abnormal_salivary_gland0.92397370
127MP0010030_abnormal_orbit_morphology0.92166502
128MP0003172_abnormal_lysosome_physiology0.91940602
129MP0001765_abnormal_ion_homeostasis0.91218431
130MP0008789_abnormal_olfactory_epithelium0.91153478
131MP0005310_abnormal_salivary_gland0.90720914
132MP0002089_abnormal_postnatal_growth/wei0.90368857
133MP0009780_abnormal_chondrocyte_physiolo0.88763144
134MP0001853_heart_inflammation0.88044857
135MP0002019_abnormal_tumor_incidence0.88039221
136MP0005076_abnormal_cell_differentiation0.86438061
137MP0004185_abnormal_adipocyte_glucose0.86202607
138MP0006082_CNS_inflammation0.84719977
139MP0005636_abnormal_mineral_homeostasis0.84594414
140MP0005670_abnormal_white_adipose0.83608891
141MP0001919_abnormal_reproductive_system0.82389654
142MP0010771_integument_phenotype0.82063083
143MP0000467_abnormal_esophagus_morphology0.81301799
144MP0008469_abnormal_protein_level0.79707751
145MP0008877_abnormal_DNA_methylation0.79675049
146MP0009765_abnormal_xenobiotic_induced0.79435291
147MP0002138_abnormal_hepatobiliary_system0.78912339
148MP0000762_abnormal_tongue_morphology0.78481799
149MP0000013_abnormal_adipose_tissue0.78424559
150MP0000367_abnormal_coat/_hair0.77805493
151MP0002118_abnormal_lipid_homeostasis0.77462829
152MP0010678_abnormal_skin_adnexa0.77427605
153MP0005367_renal/urinary_system_phenotyp0.76075853
154MP0000516_abnormal_urinary_system0.76075853
155MP0003183_abnormal_peptide_metabolism0.75982465
156MP0000427_abnormal_hair_cycle0.75947421
157MP0001756_abnormal_urination0.75857206
158MP0004130_abnormal_muscle_cell0.74857629
159MP0002928_abnormal_bile_duct0.74842586
160MP0003718_maternal_effect0.74625330
161MP0004782_abnormal_surfactant_physiolog0.74224559
162MP0009840_abnormal_foam_cell0.73530597
163MP0001191_abnormal_skin_condition0.72754074
164MP0003136_yellow_coat_color0.72351647

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)3.55293121
2Parakeratosis (HP:0001036)3.29411441
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.25772014
4Agammaglobulinemia (HP:0004432)3.18294474
5IgM deficiency (HP:0002850)3.18159166
6Pustule (HP:0200039)3.17717426
7Chromsome breakage (HP:0040012)3.14384474
8Cellulitis (HP:0100658)3.13053339
9B lymphocytopenia (HP:0010976)2.91392141
10Abnormality of B cell number (HP:0010975)2.91392141
11Abnormality of the pons (HP:0007361)2.90584996
12Hypoplasia of the pons (HP:0012110)2.89944192
13Abnormal number of erythroid precursors (HP:0012131)2.87513215
14Abnormality of the intervertebral disk (HP:0005108)2.86708632
15Albinism (HP:0001022)2.84843780
16Meningitis (HP:0001287)2.84184859
17Prolonged bleeding time (HP:0003010)2.81565294
18Increased IgE level (HP:0003212)2.78186476
19Microretrognathia (HP:0000308)2.77607032
20Congenital stationary night blindness (HP:0007642)2.77332254
21Abnormality of midbrain morphology (HP:0002418)2.76552322
22Molar tooth sign on MRI (HP:0002419)2.76552322
23Concave nail (HP:0001598)2.72619771
24Rectal prolapse (HP:0002035)2.71859041
25Recurrent bacterial skin infections (HP:0005406)2.70620387
26Hyperthyroidism (HP:0000836)2.70225613
27Recurrent fungal infections (HP:0002841)2.69397054
28Recurrent abscess formation (HP:0002722)2.66041535
29Erythroderma (HP:0001019)2.65139508
30Seborrheic dermatitis (HP:0001051)2.62782966
31Abnormality of DNA repair (HP:0003254)2.62782960
32Eczematoid dermatitis (HP:0000976)2.62289040
33Type II lissencephaly (HP:0007260)2.60848554
34Thick nail (HP:0001805)2.60354109
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.60336474
36Mesangial abnormality (HP:0001966)2.58816071
37Abnormality of nail color (HP:0100643)2.57418107
38Amelogenesis imperfecta (HP:0000705)2.57297875
39Cortical visual impairment (HP:0100704)2.56346834
40Cheilitis (HP:0100825)2.53257339
41Recurrent viral infections (HP:0004429)2.52574274
42Onycholysis (HP:0001806)2.48516311
43Osteomyelitis (HP:0002754)2.48343329
44Methylmalonic aciduria (HP:0012120)2.46162825
45Panhypogammaglobulinemia (HP:0003139)2.46116538
46Granulocytopenia (HP:0001913)2.45789815
47Poikiloderma (HP:0001029)2.45447274
48Lip pit (HP:0100267)2.44587221
49Abnormality of the renal collecting system (HP:0004742)2.43774691
50Abnormality of cells of the erythroid lineage (HP:0012130)2.42370742
51Chronic otitis media (HP:0000389)2.41210919
52Ketosis (HP:0001946)2.38653847
53Tubular atrophy (HP:0000092)2.37867923
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37154657
55Congenital ichthyosiform erythroderma (HP:0007431)2.36535375
56Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.35641977
57Squamous cell carcinoma (HP:0002860)2.35414649
58Thyroiditis (HP:0100646)2.35241157
59Abnormal rod and cone electroretinograms (HP:0008323)2.33634932
60Recurrent bronchitis (HP:0002837)2.33415281
61Duplicated collecting system (HP:0000081)2.33143197
62Sepsis (HP:0100806)2.32133157
63Eosinophilia (HP:0001880)2.31186509
64Abnormal drinking behavior (HP:0030082)2.29529105
65Polydipsia (HP:0001959)2.29529105
66Severe muscular hypotonia (HP:0006829)2.28978067
67Small epiphyses (HP:0010585)2.27951135
68Severe combined immunodeficiency (HP:0004430)2.27494915
69Abnormality of the renal cortex (HP:0011035)2.26888268
70Gingival bleeding (HP:0000225)2.26660375
71Reticulocytopenia (HP:0001896)2.24982392
72Abnormality of the preputium (HP:0100587)2.24192716
73Aplasia/Hypoplasia of the spleen (HP:0010451)2.22700340
74Abnormality of the aortic arch (HP:0012303)2.22190745
75Ectropion (HP:0000656)2.21478735
76Mediastinal lymphadenopathy (HP:0100721)2.21142921
77Plantar hyperkeratosis (HP:0007556)2.18079943
78Lymphangioma (HP:0100764)2.17750436
79Ectopic kidney (HP:0000086)2.16461349
80Recurrent pneumonia (HP:0006532)2.16070393
81Hypochromic anemia (HP:0001931)2.14934373
82Attenuation of retinal blood vessels (HP:0007843)2.14647264
83Absent speech (HP:0001344)2.14426323
84Skin ulcer (HP:0200042)2.13882975
85Abnormal platelet volume (HP:0011876)2.13408850
86Abnormality of eosinophils (HP:0001879)2.12444181
87Polyuria (HP:0000103)2.12202722
88Obstructive lung disease (HP:0006536)2.10533582
89Chronic obstructive pulmonary disease (HP:0006510)2.10533582
90IgG deficiency (HP:0004315)2.10324973
91Cerebellar dysplasia (HP:0007033)2.09629434
92White forelock (HP:0002211)2.09607701
93Severe visual impairment (HP:0001141)2.09530064
94Cystic liver disease (HP:0006706)2.08525208
95J-shaped sella turcica (HP:0002680)2.07961443
96Spontaneous hematomas (HP:0007420)2.05848083
97Verrucae (HP:0200043)2.05578462
98Papilloma (HP:0012740)2.05578462
99Thin bony cortex (HP:0002753)2.05516732
100Dynein arm defect of respiratory motile cilia (HP:0012255)2.05321475
101Absent/shortened dynein arms (HP:0200106)2.05321475
102Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.05254523
103Asplenia (HP:0001746)2.04929055
104Woolly hair (HP:0002224)2.02979912
105Recurrent skin infections (HP:0001581)2.02848846
106Clubbing of toes (HP:0100760)2.02666525
107Milia (HP:0001056)2.01406215
108Encephalitis (HP:0002383)2.01370216
109Chronic sinusitis (HP:0011109)2.00465830
110Abnormality of incisor morphology (HP:0011063)2.00275615
111Bone marrow hypocellularity (HP:0005528)1.99684364
112Abnormality of hair growth rate (HP:0011363)1.99558828
113Slow-growing hair (HP:0002217)1.99558828
114Abnormality of the fingertips (HP:0001211)1.99251706
115Pendular nystagmus (HP:0012043)1.98566364
116Aplasia cutis congenita (HP:0001057)1.98021527
117Abnormal pancreas size (HP:0012094)1.97800064
118Abnormality of T cell physiology (HP:0011840)1.96838425
119Rib fusion (HP:0000902)1.95813920
120Abnormality of T cells (HP:0002843)1.95735700
121Inflammation of the large intestine (HP:0002037)1.95175784
122Pancreatic cysts (HP:0001737)1.94917227
123Abnormality of the renal medulla (HP:0100957)1.94867316
124Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94830267
125T lymphocytopenia (HP:0005403)1.94577297
126Joint hemorrhage (HP:0005261)1.94557301
127Congenital, generalized hypertrichosis (HP:0004540)1.94309842
128Truncus arteriosus (HP:0001660)1.93025039
129Nephronophthisis (HP:0000090)1.92538537
130Myositis (HP:0100614)1.92484233
131Sparse scalp hair (HP:0002209)1.92468052
132Pruritus (HP:0000989)1.91942839
133Type I diabetes mellitus (HP:0100651)1.91045460
134Leukocytosis (HP:0001974)1.91006514
135Retinal atrophy (HP:0001105)1.90704375
136Dicarboxylic aciduria (HP:0003215)1.90337677
137Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90337677
138Gastrointestinal inflammation (HP:0004386)1.89911948
139Combined immunodeficiency (HP:0005387)1.88739508
140Palmoplantar hyperkeratosis (HP:0000972)1.87615951
141IgA deficiency (HP:0002720)1.86898304
142Patchy hypopigmentation of hair (HP:0011365)1.86812542
143Abnormality of T cell number (HP:0011839)1.86322623
144Purpura (HP:0000979)1.85505546
145Sparse eyelashes (HP:0000653)1.85356052
146Large for gestational age (HP:0001520)1.85308189
147Chronic mucocutaneous candidiasis (HP:0002728)1.84404501
148Recurrent cutaneous fungal infections (HP:0011370)1.84404501
149Abnormal respiratory motile cilium morphology (HP:0005938)1.84182799
150Abnormal respiratory epithelium morphology (HP:0012253)1.84182799
151Patellar aplasia (HP:0006443)1.84132434
152Abnormal urine output (HP:0012590)1.84080115
153Gangrene (HP:0100758)1.83503125
154Skin rash (HP:0000988)1.83487077
155Easy fatigability (HP:0003388)1.83359111
156Epistaxis (HP:0000421)1.83299029
157Recurrent lower respiratory tract infections (HP:0002783)1.83276969
158Renal dysplasia (HP:0000110)1.83157436
159Methylmalonic acidemia (HP:0002912)1.82515868
160Conical tooth (HP:0000698)1.82512935
161Hypoplasia of the thymus (HP:0000778)1.82211926
162Corneal erosion (HP:0200020)1.81735426
163Alopecia of scalp (HP:0002293)1.81414026
164Palmar hyperkeratosis (HP:0010765)1.81338140
165Optic nerve coloboma (HP:0000588)1.80776470
166Aplasia/Hypoplasia of the patella (HP:0006498)1.80699757
167Increased neuronal autofluorescent lipopigment (HP:0002074)1.80476008
168Genetic anticipation (HP:0003743)1.79708111
169Erythema (HP:0010783)1.79217646
170Testicular atrophy (HP:0000029)1.78355183
171Lymphoma (HP:0002665)1.77618203
172Abnormality of polysaccharide metabolism (HP:0011012)1.77392165
173Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77392165
174Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77392165
175Absent thumb (HP:0009777)1.75253112
176Ketoacidosis (HP:0001993)1.75166269
177Hypoplasia of the uterus (HP:0000013)1.74570806
178Abnormality of renal excretion (HP:0011036)1.74030152
179Fragile nails (HP:0001808)1.72691077
180Prolonged partial thromboplastin time (HP:0003645)1.72337970
181Oral leukoplakia (HP:0002745)1.72277877
182Elevated erythrocyte sedimentation rate (HP:0003565)1.72030257
183Abnormality of small intestinal villus morphology (HP:0011472)1.69140773
184Villous atrophy (HP:0011473)1.69140773
185Abnormal biliary tract physiology (HP:0012439)1.68773189
186Bile duct proliferation (HP:0001408)1.68773189
187Pancreatic fibrosis (HP:0100732)1.67161959
188Ulnar claw (HP:0001178)1.66490569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.90680707
2TRIB33.51175965
3TLK13.30116716
4TESK22.99304727
5WNK42.98893312
6BLK2.96173626
7MAP4K12.86107873
8FRK2.80076072
9IRAK42.74782977
10MAP3K102.50322839
11VRK22.45444737
12SMG12.44366397
13BCKDK2.42685738
14PRKD22.33511537
15SIK12.31591504
16BUB12.31408744
17STK162.24913130
18TRPM72.12011094
19MAP3K142.10138017
20TXK2.09622386
21EPHA22.04703539
22STK241.91884561
23ZAK1.90733059
24RPS6KB21.81503986
25BTK1.80957183
26EEF2K1.79401924
27MAPK151.78441679
28PLK41.76220592
29PIM21.58587585
30PKN21.57232186
31GRK61.51847043
32TEC1.47257920
33PRKCI1.46135879
34CLK11.43682589
35STK101.41812907
36TNK21.39000987
37MUSK1.37343709
38PIM11.29528602
39NLK1.27387725
40IKBKB1.20230287
41YES11.19226994
42TYK21.19117861
43EIF2AK31.15746519
44EIF2AK21.15612117
45SIK31.14142795
46ERBB31.13455963
47MAP4K21.11749466
48MKNK11.10153621
49EIF2AK11.09840457
50JAK31.09773237
51CDK81.09114082
52ZAP701.08120752
53MST41.07475798
54RPS6KA21.07015597
55STK381.04552147
56MAP3K71.04235337
57SYK1.03169003
58SRPK11.02991189
59HIPK21.02687204
60CDK121.00738699
61STK41.00407255
62IKBKE1.00146283
63MARK20.98943127
64TAOK30.98592399
65PINK10.97597726
66MAP3K30.97314325
67CHUK0.96319423
68LYN0.95713732
69NEK20.95409410
70TSSK60.94150794
71ERN10.93693875
72MAP2K60.92846952
73RPS6KA40.92483372
74GRK10.91899703
75PRPF4B0.91404942
76FLT30.86698565
77TAOK20.86466203
78ABL20.85549550
79MKNK20.85018105
80PRKCH0.84607038
81BRD40.83278502
82CSK0.82386070
83MST1R0.79380343
84HCK0.79274643
85CDK40.79063586
86NME20.78440966
87ITK0.77641160
88MAPK40.76578923
89ICK0.76194998
90NUAK10.74910493
91ATR0.74410177
92ADRBK20.72872643
93DYRK1B0.72295963
94PIK3CG0.72103388
95AURKB0.71781051
96VRK10.70925628
97PRKAA10.68824750
98PDPK10.68749885
99MAP2K30.67441689
100PASK0.67150221
101MAPKAPK50.66693831
102CAMK1D0.66202894
103CDK70.66038733
104IRAK10.65905614
105KIT0.65755776
106INSRR0.65683057
107ADRBK10.65645856
108SIK20.64507387
109MAPK70.64449566
110MAP3K110.64087466
111MAPK110.63908274
112LCK0.63318010
113STK38L0.61555860
114STK390.61549021
115MAP2K70.61378825
116MAPKAPK20.60278874
117MAP2K20.59298619
118TAF10.57698505
119CDC42BPA0.57609246
120BMPR20.57548254
121FGFR30.57362240
122EPHA30.57346760
123PRKAA20.57047610
124MAPKAPK30.55207358
125BMPR1B0.54956587
126RPS6KA50.54528593
127EPHB10.54505410
128RPS6KA60.53598062
129MELK0.53120970
130SGK20.52623228
131TBK10.52512698
132STK30.51432957
133PTK60.51339093
134MARK30.50502377
135MTOR0.49640574
136OXSR10.48947119
137RPS6KC10.48851752
138RPS6KL10.48851752
139RPS6KA10.48694302
140NME10.48171882
141PTK2B0.47091496
142FGFR40.45846065
143CAMKK10.45148316
144DYRK30.45142077
145MAPK30.44706371
146CSF1R0.42045722
147TGFBR10.41300800
148PDK10.40392521
149MATK0.38249440
150MAPK80.34196564
151DAPK30.32688826
152CDK90.30337685
153PRKD10.28972643
154FGFR20.28520885
155CSNK1A10.28068087

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.55138230
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.14205625
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.89759907
4Primary immunodeficiency_Homo sapiens_hsa053402.78094404
5Base excision repair_Homo sapiens_hsa034102.57367474
6Homologous recombination_Homo sapiens_hsa034402.50633688
7DNA replication_Homo sapiens_hsa030302.36616264
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.20283018
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19158987
10Non-homologous end-joining_Homo sapiens_hsa034502.11755402
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.11646032
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.06243038
13Fanconi anemia pathway_Homo sapiens_hsa034602.02903463
14Mismatch repair_Homo sapiens_hsa034302.01309923
15One carbon pool by folate_Homo sapiens_hsa006701.98047369
16ABC transporters_Homo sapiens_hsa020101.97401496
17RNA polymerase_Homo sapiens_hsa030201.76833928
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76034704
19Ribosome_Homo sapiens_hsa030101.75792489
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68608836
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.61900237
22Measles_Homo sapiens_hsa051621.61502167
23Arachidonic acid metabolism_Homo sapiens_hsa005901.53190273
24Hematopoietic cell lineage_Homo sapiens_hsa046401.52069659
25Pyrimidine metabolism_Homo sapiens_hsa002401.50906913
26Spliceosome_Homo sapiens_hsa030401.50261259
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.48800852
28Systemic lupus erythematosus_Homo sapiens_hsa053221.48785671
29Herpes simplex infection_Homo sapiens_hsa051681.41218173
30Leishmaniasis_Homo sapiens_hsa051401.39681536
31Proteasome_Homo sapiens_hsa030501.38089987
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35608564
33Asthma_Homo sapiens_hsa053101.35060690
34Nucleotide excision repair_Homo sapiens_hsa034201.34053265
35B cell receptor signaling pathway_Homo sapiens_hsa046621.33302388
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.28781104
37Cell cycle_Homo sapiens_hsa041101.26609196
38p53 signaling pathway_Homo sapiens_hsa041151.25351817
39Protein export_Homo sapiens_hsa030601.25062282
40Fructose and mannose metabolism_Homo sapiens_hsa000511.22759459
41Staphylococcus aureus infection_Homo sapiens_hsa051501.13513731
42Folate biosynthesis_Homo sapiens_hsa007901.12410625
43Antigen processing and presentation_Homo sapiens_hsa046121.12401170
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11949092
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10881615
46Histidine metabolism_Homo sapiens_hsa003401.10782198
47Graft-versus-host disease_Homo sapiens_hsa053321.10372206
48Caffeine metabolism_Homo sapiens_hsa002321.10286216
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09751993
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09329381
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09170208
52Regulation of autophagy_Homo sapiens_hsa041401.08327601
53Basal transcription factors_Homo sapiens_hsa030221.07679772
54Butanoate metabolism_Homo sapiens_hsa006501.07445911
55RNA degradation_Homo sapiens_hsa030181.06662758
56Influenza A_Homo sapiens_hsa051641.05473107
57Apoptosis_Homo sapiens_hsa042101.01751680
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01352352
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00677034
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99738455
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98782729
62Epstein-Barr virus infection_Homo sapiens_hsa051690.96802333
63Other glycan degradation_Homo sapiens_hsa005110.96794367
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96691215
65Insulin resistance_Homo sapiens_hsa049310.94654784
66Allograft rejection_Homo sapiens_hsa053300.93969196
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.93617094
68Renin-angiotensin system_Homo sapiens_hsa046140.92990568
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92172755
70Phototransduction_Homo sapiens_hsa047440.90918045
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89842932
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89413044
73Ether lipid metabolism_Homo sapiens_hsa005650.89313365
74Linoleic acid metabolism_Homo sapiens_hsa005910.88309122
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85608137
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85165791
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84084467
78Notch signaling pathway_Homo sapiens_hsa043300.83627489
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82139813
80Retinol metabolism_Homo sapiens_hsa008300.82004888
81Sphingolipid metabolism_Homo sapiens_hsa006000.81883104
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81248876
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79855119
84RNA transport_Homo sapiens_hsa030130.79586122
85Fat digestion and absorption_Homo sapiens_hsa049750.79180529
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77242495
87Osteoclast differentiation_Homo sapiens_hsa043800.76230273
88Malaria_Homo sapiens_hsa051440.75645398
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74997491
90Sulfur metabolism_Homo sapiens_hsa009200.73788375
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.73625004
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.73568943
93T cell receptor signaling pathway_Homo sapiens_hsa046600.73263489
94Legionellosis_Homo sapiens_hsa051340.73194849
95Vitamin digestion and absorption_Homo sapiens_hsa049770.72177789
96Metabolic pathways_Homo sapiens_hsa011000.71788857
97Chemical carcinogenesis_Homo sapiens_hsa052040.69862371
98Type I diabetes mellitus_Homo sapiens_hsa049400.69725260
99Glutathione metabolism_Homo sapiens_hsa004800.69323119
100Acute myeloid leukemia_Homo sapiens_hsa052210.68049090
101Oxidative phosphorylation_Homo sapiens_hsa001900.68000704
102mRNA surveillance pathway_Homo sapiens_hsa030150.67911035
103HTLV-I infection_Homo sapiens_hsa051660.67787565
104Ovarian steroidogenesis_Homo sapiens_hsa049130.66993387
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.66550097
106Hepatitis B_Homo sapiens_hsa051610.66280867
107Autoimmune thyroid disease_Homo sapiens_hsa053200.66117397
108Purine metabolism_Homo sapiens_hsa002300.65242741
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.64657631
110Lysine degradation_Homo sapiens_hsa003100.64500506
111Toxoplasmosis_Homo sapiens_hsa051450.64224625
112Complement and coagulation cascades_Homo sapiens_hsa046100.64044558
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60823012
114Phenylalanine metabolism_Homo sapiens_hsa003600.60702800
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60279211
116Steroid biosynthesis_Homo sapiens_hsa001000.59770401
117Basal cell carcinoma_Homo sapiens_hsa052170.58776995
118Arginine biosynthesis_Homo sapiens_hsa002200.57400525
119Hepatitis C_Homo sapiens_hsa051600.57016406
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56498759
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55781460
122Pertussis_Homo sapiens_hsa051330.54347441
123Tyrosine metabolism_Homo sapiens_hsa003500.52569082
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51745103
125Viral carcinogenesis_Homo sapiens_hsa052030.50845708
126Fatty acid degradation_Homo sapiens_hsa000710.50605242
127Shigellosis_Homo sapiens_hsa051310.48516435
128MicroRNAs in cancer_Homo sapiens_hsa052060.48507866
129Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48374415
130Peroxisome_Homo sapiens_hsa041460.47442842
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46746441
132beta-Alanine metabolism_Homo sapiens_hsa004100.46586588
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46507520
134Small cell lung cancer_Homo sapiens_hsa052220.46205617
135Tryptophan metabolism_Homo sapiens_hsa003800.44927843
136Inositol phosphate metabolism_Homo sapiens_hsa005620.44845495
137Selenocompound metabolism_Homo sapiens_hsa004500.43263027
138N-Glycan biosynthesis_Homo sapiens_hsa005100.42435409
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41730978
140Type II diabetes mellitus_Homo sapiens_hsa049300.39834779
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38307867
142Starch and sucrose metabolism_Homo sapiens_hsa005000.37860057
143Collecting duct acid secretion_Homo sapiens_hsa049660.36545003
144mTOR signaling pathway_Homo sapiens_hsa041500.36349666
145TNF signaling pathway_Homo sapiens_hsa046680.34967139

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