PHLPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.30615582
2central nervous system myelination (GO:0022010)7.30615582
3postsynaptic membrane organization (GO:0001941)5.22113584
4myelination (GO:0042552)4.60597443
5ensheathment of neurons (GO:0007272)4.57831502
6axon ensheathment (GO:0008366)4.57831502
7L-amino acid import (GO:0043092)4.27375918
8synaptic vesicle maturation (GO:0016188)3.92731617
9negative regulation of neurotransmitter secretion (GO:0046929)3.89892747
10locomotory exploration behavior (GO:0035641)3.77034901
11negative regulation of neurotransmitter transport (GO:0051589)3.67823624
12fatty acid elongation (GO:0030497)3.60271568
13neuronal action potential propagation (GO:0019227)3.56010707
14synaptic vesicle docking involved in exocytosis (GO:0016081)3.52418213
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.46320130
16myelin maintenance (GO:0043217)3.46158155
17C4-dicarboxylate transport (GO:0015740)3.45313332
18regulation of short-term neuronal synaptic plasticity (GO:0048172)3.42703095
19neurotransmitter uptake (GO:0001504)3.41264457
20long-chain fatty acid biosynthetic process (GO:0042759)3.40658889
21oligodendrocyte differentiation (GO:0048709)3.38801566
22amino acid import (GO:0043090)3.38424249
23presynaptic membrane organization (GO:0097090)3.38331657
24dendritic spine morphogenesis (GO:0060997)3.32619152
25neuron cell-cell adhesion (GO:0007158)3.32422681
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.31800789
27gamma-aminobutyric acid transport (GO:0015812)3.24396492
28neuronal ion channel clustering (GO:0045161)3.24222928
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.22623940
30establishment of nucleus localization (GO:0040023)3.19487907
31transmission of nerve impulse (GO:0019226)3.19357167
32myelination in peripheral nervous system (GO:0022011)3.19193865
33peripheral nervous system axon ensheathment (GO:0032292)3.19193865
34presynaptic membrane assembly (GO:0097105)3.15258591
35mechanosensory behavior (GO:0007638)3.15166945
36eye photoreceptor cell differentiation (GO:0001754)3.13801584
37photoreceptor cell differentiation (GO:0046530)3.13801584
38adult walking behavior (GO:0007628)3.12441998
39peptidyl-tyrosine autophosphorylation (GO:0038083)3.09059668
40glutamate secretion (GO:0014047)3.06796332
41negative regulation of astrocyte differentiation (GO:0048712)3.06384721
42regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.05211988
43glycine transport (GO:0015816)3.05036070
44astrocyte development (GO:0014002)3.04571382
45regulation of neuronal synaptic plasticity (GO:0048168)3.01529708
46nerve growth factor signaling pathway (GO:0038180)3.00578731
47synaptic vesicle endocytosis (GO:0048488)2.99586714
48synaptic vesicle exocytosis (GO:0016079)2.99351956
49asymmetric protein localization (GO:0008105)2.97759368
50regulation of synaptic vesicle exocytosis (GO:2000300)2.97387351
51cellular sodium ion homeostasis (GO:0006883)2.97362840
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.96321250
53negative regulation of protein localization to cell surface (GO:2000009)2.95901575
54apical protein localization (GO:0045176)2.94664610
55regulation of long-term neuronal synaptic plasticity (GO:0048169)2.94185888
56negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.93784986
57negative regulation of translation, ncRNA-mediated (GO:0040033)2.93784986
58regulation of translation, ncRNA-mediated (GO:0045974)2.93784986
59layer formation in cerebral cortex (GO:0021819)2.92896700
60vocalization behavior (GO:0071625)2.91525155
61cellular potassium ion homeostasis (GO:0030007)2.90570861
62regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89069402
63auditory behavior (GO:0031223)2.87705569
64acidic amino acid transport (GO:0015800)2.84818866
65glutamate receptor signaling pathway (GO:0007215)2.83063179
66regulation of posttranscriptional gene silencing (GO:0060147)2.80924292
67regulation of gene silencing by miRNA (GO:0060964)2.80924292
68regulation of gene silencing by RNA (GO:0060966)2.80924292
69cellular response to cholesterol (GO:0071397)2.80638226
70atrial cardiac muscle cell action potential (GO:0086014)2.79920699
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.79705435
72synaptic transmission, glutamatergic (GO:0035249)2.79205593
73sodium ion export (GO:0071436)2.78972906
74neurotransmitter secretion (GO:0007269)2.78456452
75dendrite morphogenesis (GO:0048813)2.77843772
76neuron recognition (GO:0008038)2.77548088
77response to methylmercury (GO:0051597)2.76509291
78negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.75934323
79startle response (GO:0001964)2.75101400
80potassium ion import (GO:0010107)2.74512356
81establishment of mitochondrion localization (GO:0051654)2.74285408
82creatine metabolic process (GO:0006600)2.72474161
83cerebellar granule cell differentiation (GO:0021707)2.72303327
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.71688091
85protein localization to synapse (GO:0035418)2.71318504
86negative regulation of inclusion body assembly (GO:0090084)2.69943801
87regulation of glutamate receptor signaling pathway (GO:1900449)2.66311081
88cerebellar Purkinje cell differentiation (GO:0021702)2.65643508
89negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.64796698
90regulation of dendritic spine morphogenesis (GO:0061001)2.63818432
91neurotransmitter-gated ion channel clustering (GO:0072578)2.62470202
92negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62152529
93negative regulation of axonogenesis (GO:0050771)2.61153135
94axonal fasciculation (GO:0007413)2.58989957
95dendritic spine organization (GO:0097061)2.58410583
96membrane tubulation (GO:0097320)2.58308630
97L-glutamate transport (GO:0015813)2.58222521
98regulation of voltage-gated calcium channel activity (GO:1901385)2.57457996
99neuron-neuron synaptic transmission (GO:0007270)2.57197303
100glycerophospholipid catabolic process (GO:0046475)2.57116284
101cellular response to sterol (GO:0036315)2.56856707
102cerebral cortex radially oriented cell migration (GO:0021799)2.55687087
103mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.55288239
104negative regulation of glial cell differentiation (GO:0045686)2.55210507
105cochlea development (GO:0090102)2.53747519
106exploration behavior (GO:0035640)2.53204911
107neurotransmitter transport (GO:0006836)2.52881018
108regulation of synaptic vesicle transport (GO:1902803)2.51421919
109import into cell (GO:0098657)2.51303488
110lateral sprouting from an epithelium (GO:0060601)2.51139041
111cytoskeletal anchoring at plasma membrane (GO:0007016)2.50443619
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.50346422
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49630914
114embryonic retina morphogenesis in camera-type eye (GO:0060059)2.48567361
115regulation of dendritic spine development (GO:0060998)2.47629610
116long-term memory (GO:0007616)2.47576768
117neuromuscular process controlling balance (GO:0050885)2.46832192
118regulation of ARF protein signal transduction (GO:0032012)2.46808141
119regulation of excitatory postsynaptic membrane potential (GO:0060079)2.46807788
120regulation of respiratory system process (GO:0044065)2.45872287
121potassium ion homeostasis (GO:0055075)2.45425468
122innervation (GO:0060384)2.44768484
123cyclic nucleotide catabolic process (GO:0009214)2.43978066
124positive regulation of dendritic spine morphogenesis (GO:0061003)2.43966376
125nonmotile primary cilium assembly (GO:0035058)2.42625215
126acrosome reaction (GO:0007340)2.42054134
127positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.41691754
128response to auditory stimulus (GO:0010996)2.41210214
129cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.40501994
130regulation of neurotransmitter levels (GO:0001505)2.39621477
131positive regulation of dendritic spine development (GO:0060999)2.39294296
132cellular response to monoamine stimulus (GO:0071868)2.39138968
133cellular response to catecholamine stimulus (GO:0071870)2.39138968
134gamma-aminobutyric acid signaling pathway (GO:0007214)2.38800836
135positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.38072203
136regulation of synaptic plasticity (GO:0048167)2.37712273
137regulation of synapse structural plasticity (GO:0051823)2.37354604
138cell communication by electrical coupling (GO:0010644)2.37213514
139positive regulation of oligodendrocyte differentiation (GO:0048714)2.36497791
140regulation of collateral sprouting (GO:0048670)2.36316025
141mating behavior (GO:0007617)2.36048071
142regulation of ARF GTPase activity (GO:0032312)2.35862487
143protein localization to endosome (GO:0036010)2.34879847

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.06948219
2GBX2_23144817_ChIP-Seq_PC3_Human2.84570660
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51494403
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45817998
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.32791806
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32058259
7DROSHA_22980978_ChIP-Seq_HELA_Human2.31946650
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27343032
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21201652
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21201652
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20402512
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16166848
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06124337
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02177353
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.01428231
16* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01194990
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99987840
18EZH2_27294783_Chip-Seq_ESCs_Mouse1.97999795
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97806641
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.95212781
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91300432
22RARB_27405468_Chip-Seq_BRAIN_Mouse1.87692471
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.86932039
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82052844
25AR_21572438_ChIP-Seq_LNCaP_Human1.80570454
26RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.77890491
27REST_21632747_ChIP-Seq_MESCs_Mouse1.76118083
28* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70907020
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60035434
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58111325
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49249977
32RNF2_27304074_Chip-Seq_NSC_Mouse1.48184713
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47625722
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43840543
35* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41675045
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39858589
37CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38860144
38IGF1R_20145208_ChIP-Seq_DFB_Human1.38694284
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38624749
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.37286738
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36416985
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.35085128
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33905745
44* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32807153
45TAF15_26573619_Chip-Seq_HEK293_Human1.32653238
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32261651
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32156494
48* FUS_26573619_Chip-Seq_HEK293_Human1.31646054
49* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30673504
50WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30402170
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27419398
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26220049
53* SMAD3_21741376_ChIP-Seq_EPCs_Human1.26043232
54EWS_26573619_Chip-Seq_HEK293_Human1.25027478
55SMAD4_21799915_ChIP-Seq_A2780_Human1.24289880
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23402833
57* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22384502
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21253281
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21132964
60AHR_22903824_ChIP-Seq_MCF-7_Human1.19305665
61YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18652485
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.17894237
63SOX9_26525672_Chip-Seq_HEART_Mouse1.17735840
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16179662
65CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16053608
66* RING1B_27294783_Chip-Seq_ESCs_Mouse1.15891105
67* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15375021
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.15158342
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.14824406
70* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13250213
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13225036
72* STAT3_23295773_ChIP-Seq_U87_Human1.12613089
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12376675
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11455551
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10823208
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10572026
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.10167452
78RUNX2_22187159_ChIP-Seq_PCA_Human1.10038640
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10031111
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.09364386
81POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08804319
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08095385
83TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06945503
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06397730
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.06092152
86P300_19829295_ChIP-Seq_ESCs_Human1.05966881
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05608412
88TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05517278
89TCF4_23295773_ChIP-Seq_U87_Human1.05288405
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03397701
91CBP_20019798_ChIP-Seq_JUKART_Human1.03397701
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.03305513
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03300113
94* RING1B_27294783_Chip-Seq_NPCs_Mouse1.02412934
95BCAT_22108803_ChIP-Seq_LS180_Human1.01220025
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.00902401
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00168470
98NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99067995
99ER_23166858_ChIP-Seq_MCF-7_Human0.98657372
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98531854
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97860086
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97567215
103P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97147245
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96619634
105AR_19668381_ChIP-Seq_PC3_Human0.96600796
106KDM2B_26808549_Chip-Seq_K562_Human0.95820483
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.93805254
108TRIM28_21343339_ChIP-Seq_HEK293_Human0.93088851
109TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92996312
110SMAD_19615063_ChIP-ChIP_OVARY_Human0.92937167
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90815058
112* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90779232
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90595988
114ESR2_21235772_ChIP-Seq_MCF-7_Human0.90169145
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.89849212
116CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89384810
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88200318
118NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88200318
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87881415
120TP53_16413492_ChIP-PET_HCT116_Human0.87647607
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.87605744
122RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87176581
123LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86375968
124AR_25329375_ChIP-Seq_VCAP_Human0.86045629
125DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85708050
126FOXA2_19822575_ChIP-Seq_HepG2_Human0.85516972
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84513083
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84513083
129SMAD4_21741376_ChIP-Seq_EPCs_Human0.83041186
130PRDM14_20953172_ChIP-Seq_ESCs_Human0.82702969
131* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82554145

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.90272024
2MP0003880_abnormal_central_pattern4.27931829
3MP0000920_abnormal_myelination3.76981362
4MP0004270_analgesia3.38810615
5MP0003690_abnormal_glial_cell3.14150645
6MP0003635_abnormal_synaptic_transmissio3.12820831
7MP0000566_synostosis2.87874545
8MP0002064_seizures2.85082797
9MP0001486_abnormal_startle_reflex2.81949541
10MP0003329_amyloid_beta_deposits2.68257031
11MP0009745_abnormal_behavioral_response2.67064856
12MP0002272_abnormal_nervous_system2.66204440
13MP0004885_abnormal_endolymph2.64597947
14MP0009046_muscle_twitch2.64561861
15MP0005410_abnormal_fertilization2.63803292
16MP0006292_abnormal_olfactory_placode2.63112274
17MP0008877_abnormal_DNA_methylation2.57212260
18MP0002063_abnormal_learning/memory/cond2.46388771
19MP0005423_abnormal_somatic_nervous2.37325646
20MP0000569_abnormal_digit_pigmentation2.34040326
21MP0003634_abnormal_glial_cell2.18782792
22MP0000778_abnormal_nervous_system2.16070560
23MP0003950_abnormal_plasma_membrane2.10427008
24MP0002572_abnormal_emotion/affect_behav2.07869317
25MP0008569_lethality_at_weaning1.93933828
26MP0005171_absent_coat_pigmentation1.85507975
27MP0002822_catalepsy1.85204343
28MP0002734_abnormal_mechanical_nocicepti1.85092378
29MP0002653_abnormal_ependyma_morphology1.80052266
30MP0004742_abnormal_vestibular_system1.79972346
31MP0009780_abnormal_chondrocyte_physiolo1.76856828
32MP0004142_abnormal_muscle_tone1.76381289
33MP0001440_abnormal_grooming_behavior1.69518056
34MP0003633_abnormal_nervous_system1.66885681
35MP0000955_abnormal_spinal_cord1.66259451
36MP0005646_abnormal_pituitary_gland1.65842381
37MP0002229_neurodegeneration1.59204084
38MP0002067_abnormal_sensory_capabilities1.56293545
39MP0003631_nervous_system_phenotype1.54730606
40MP0001905_abnormal_dopamine_level1.54232304
41MP0003632_abnormal_nervous_system1.53852576
42MP0001485_abnormal_pinna_reflex1.53466375
43MP0004924_abnormal_behavior1.52556793
44MP0005386_behavior/neurological_phenoty1.52556793
45MP0000604_amyloidosis1.50389378
46MP0002882_abnormal_neuron_morphology1.50116277
47MP0003890_abnormal_embryonic-extraembry1.47128747
48MP0001968_abnormal_touch/_nociception1.46191849
49MP0005623_abnormal_meninges_morphology1.40085073
50MP0005645_abnormal_hypothalamus_physiol1.39687717
51MP0002066_abnormal_motor_capabilities/c1.39058082
52MP0001293_anophthalmia1.36461529
53MP0004858_abnormal_nervous_system1.36292245
54MP0003122_maternal_imprinting1.35193742
55MP0005499_abnormal_olfactory_system1.34272210
56MP0005394_taste/olfaction_phenotype1.34272210
57MP0001501_abnormal_sleep_pattern1.33752149
58MP0001970_abnormal_pain_threshold1.33044111
59MP0003787_abnormal_imprinting1.32766507
60MP0005551_abnormal_eye_electrophysiolog1.31087234
61MP0003938_abnormal_ear_development1.30736138
62MP0005174_abnormal_tail_pigmentation1.29626838
63MP0004811_abnormal_neuron_physiology1.29313178
64MP0002733_abnormal_thermal_nociception1.28758187
65MP0002938_white_spotting1.27917704
66MP0001529_abnormal_vocalization1.27723798
67MP0004043_abnormal_pH_regulation1.22788446
68MP0000579_abnormal_nail_morphology1.20286990
69MP0006276_abnormal_autonomic_nervous1.19311617
70MP0002557_abnormal_social/conspecific_i1.15874043
71MP0005409_darkened_coat_color1.15096491
72MP0008789_abnormal_olfactory_epithelium1.13850652
73MP0001299_abnormal_eye_distance/1.13808175
74MP0003119_abnormal_digestive_system1.12269935
75MP0003075_altered_response_to1.11519415
76MP0001177_atelectasis1.11341792
77MP0002249_abnormal_larynx_morphology1.10477351
78MP0008057_abnormal_DNA_replication1.10237916
79MP0003136_yellow_coat_color1.09500923
80MP0002184_abnormal_innervation1.08712968
81MP0002152_abnormal_brain_morphology1.08292890
82MP0002638_abnormal_pupillary_reflex1.05647593
83MP0002736_abnormal_nociception_after1.03415594
84MP0003121_genomic_imprinting1.02923081
85MP0003937_abnormal_limbs/digits/tail_de1.00254520
86MP0004133_heterotaxia1.00223907
87MP0002735_abnormal_chemical_nociception0.96991720
88MP0002090_abnormal_vision0.95168044
89MP0004145_abnormal_muscle_electrophysio0.93425787
90MP0001963_abnormal_hearing_physiology0.92279768
91* MP0001502_abnormal_circadian_rhythm0.92116537
92MP0002752_abnormal_somatic_nervous0.91269762
93MP0010678_abnormal_skin_adnexa0.89577793
94MP0008874_decreased_physiological_sensi0.89335317
95MP0005167_abnormal_blood-brain_barrier0.88939965
96MP0000428_abnormal_craniofacial_morphol0.88694283
97MP0002233_abnormal_nose_morphology0.88418470
98MP0010030_abnormal_orbit_morphology0.87827085
99MP0000747_muscle_weakness0.84871958
100MP0004134_abnormal_chest_morphology0.84702890
101MP0009379_abnormal_foot_pigmentation0.83117752
102MP0005377_hearing/vestibular/ear_phenot0.82521037
103MP0003878_abnormal_ear_physiology0.82521037
104MP0003045_fibrosis0.81838871
105MP0003123_paternal_imprinting0.81519696
106MP0003137_abnormal_impulse_conducting0.80612203
107MP0000049_abnormal_middle_ear0.79116000
108MP0000751_myopathy0.77897520
109MP0002095_abnormal_skin_pigmentation0.77305478
110MP0002697_abnormal_eye_size0.77280071
111MP0003698_abnormal_male_reproductive0.75572453
112MP0002909_abnormal_adrenal_gland0.75528245
113MP0002210_abnormal_sex_determination0.75220309
114MP0001984_abnormal_olfaction0.75190802
115MP0001929_abnormal_gametogenesis0.74056890
116MP0009672_abnormal_birth_weight0.73982756
117MP0001346_abnormal_lacrimal_gland0.71582512
118MP0004036_abnormal_muscle_relaxation0.68931959
119MP0005195_abnormal_posterior_eye0.67332943
120MP0004085_abnormal_heartbeat0.67143183
121MP0000462_abnormal_digestive_system0.66408948
122MP0005253_abnormal_eye_physiology0.65825627
123MP0004510_myositis0.65427987
124MP0002069_abnormal_eating/drinking_beha0.63949280
125MP0009840_abnormal_foam_cell0.61197227
126MP0000631_abnormal_neuroendocrine_gland0.60641424
127MP0001943_abnormal_respiration0.59951873
128MP0000026_abnormal_inner_ear0.59791696
129MP0003283_abnormal_digestive_organ0.58364782
130MP0001348_abnormal_lacrimal_gland0.57642391
131MP0000383_abnormal_hair_follicle0.56324536
132MP0003879_abnormal_hair_cell0.54399369
133MP0003172_abnormal_lysosome_physiology0.54103569
134MP0002133_abnormal_respiratory_system0.54007138
135MP0005388_respiratory_system_phenotype0.54007138
136MP0002295_abnormal_pulmonary_circulatio0.53833204
137MP0003861_abnormal_nervous_system0.52787637

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.83783924
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.82635522
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.82635522
4Myokymia (HP:0002411)4.72926483
5Cerebral inclusion bodies (HP:0100314)4.60639232
6Supranuclear gaze palsy (HP:0000605)4.50690231
7Abnormality of the corticospinal tract (HP:0002492)4.16616837
8Peripheral hypomyelination (HP:0007182)3.93086734
9Focal motor seizures (HP:0011153)3.91817009
10Intention tremor (HP:0002080)3.87205340
11Action tremor (HP:0002345)3.72368262
12Dysmetria (HP:0001310)3.62452450
13Spastic gait (HP:0002064)3.61956265
14Febrile seizures (HP:0002373)3.39452698
15Ankle clonus (HP:0011448)3.36945198
16Onion bulb formation (HP:0003383)3.29145968
17Aplasia involving bones of the upper limbs (HP:0009823)3.28489962
18Aplasia of the phalanges of the hand (HP:0009802)3.28489962
19Aplasia involving bones of the extremities (HP:0009825)3.28489962
20Megalencephaly (HP:0001355)3.25447499
21Sensory axonal neuropathy (HP:0003390)3.24705131
22Focal seizures (HP:0007359)3.22304000
23Abnormality of cochlea (HP:0000375)3.12306462
24Insidious onset (HP:0003587)3.10247526
25Termporal pattern (HP:0011008)3.10247526
26Lower limb muscle weakness (HP:0007340)2.99071074
27Abnormal auditory evoked potentials (HP:0006958)2.94574959
28Dysdiadochokinesis (HP:0002075)2.91559259
29Pheochromocytoma (HP:0002666)2.89463835
30Scanning speech (HP:0002168)2.85143854
31Alacrima (HP:0000522)2.84262182
32Postural instability (HP:0002172)2.80598101
33Urinary bladder sphincter dysfunction (HP:0002839)2.77431455
34Absent/shortened dynein arms (HP:0200106)2.75255010
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.75255010
36Epileptic encephalopathy (HP:0200134)2.75213174
37Abnormality of the labia minora (HP:0012880)2.70429381
38Clumsiness (HP:0002312)2.63043643
39Split foot (HP:0001839)2.57081743
40Urinary urgency (HP:0000012)2.55103441
41Progressive cerebellar ataxia (HP:0002073)2.52422932
42Aplasia/Hypoplasia of the sternum (HP:0006714)2.50720176
43Spastic tetraparesis (HP:0001285)2.49787689
44Drooling (HP:0002307)2.49252719
45Hepatoblastoma (HP:0002884)2.46292721
46Colon cancer (HP:0003003)2.45405957
47Cutaneous finger syndactyly (HP:0010554)2.39292007
48Bronchomalacia (HP:0002780)2.38871137
49Slow saccadic eye movements (HP:0000514)2.36414792
50Atonic seizures (HP:0010819)2.30994467
51Neuroendocrine neoplasm (HP:0100634)2.30090945
52Impaired vibration sensation in the lower limbs (HP:0002166)2.30083847
53Thickened helices (HP:0000391)2.30018013
54Increased circulating renin level (HP:0000848)2.29018095
55Partial duplication of thumb phalanx (HP:0009944)2.26547304
56Akinesia (HP:0002304)2.25989946
57Visual hallucinations (HP:0002367)2.23439787
58Clonus (HP:0002169)2.22203067
59Gaze-evoked nystagmus (HP:0000640)2.20836105
60Excessive salivation (HP:0003781)2.18967589
61Hemiparesis (HP:0001269)2.17756272
62Decreased lacrimation (HP:0000633)2.17747465
63Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16540218
64Hyperventilation (HP:0002883)2.15973717
65Neuronal loss in central nervous system (HP:0002529)2.14712346
66Cutaneous syndactyly (HP:0012725)2.14565974
67Septo-optic dysplasia (HP:0100842)2.13929838
68Oligodactyly (hands) (HP:0001180)2.12287609
69Retinal dysplasia (HP:0007973)2.11154920
70Bifid scrotum (HP:0000048)2.09157436
71Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09037138
72Abnormality of the diencephalon (HP:0010662)2.08714588
73Obstructive sleep apnea (HP:0002870)2.07808834
74Broad-based gait (HP:0002136)2.07241511
75Generalized myoclonic seizures (HP:0002123)2.07009608
76Sleep apnea (HP:0010535)2.06861095
77Esophageal atresia (HP:0002032)2.06467739
78Difficulty running (HP:0009046)2.06463574
79Abnormality of saccadic eye movements (HP:0000570)2.04554372
80Ectopic kidney (HP:0000086)2.01468864
81Gastrointestinal atresia (HP:0002589)2.00129285
82Truncal ataxia (HP:0002078)1.99381864
83Anxiety (HP:0000739)1.99159992
84Depression (HP:0000716)1.99025088
85Cerebral hypomyelination (HP:0006808)1.97675249
86Blue irides (HP:0000635)1.97544924
87Bowel incontinence (HP:0002607)1.96132451
88Aqueductal stenosis (HP:0002410)1.95752676
89Genetic anticipation (HP:0003743)1.95010823
90Torticollis (HP:0000473)1.94567683
91Relative macrocephaly (HP:0004482)1.94317533
922-3 toe syndactyly (HP:0004691)1.94251999
93Dialeptic seizures (HP:0011146)1.93878016
94Chronic hepatic failure (HP:0100626)1.93717988
95Optic nerve hypoplasia (HP:0000609)1.92547384
96Protruding tongue (HP:0010808)1.92538709
97Decreased motor nerve conduction velocity (HP:0003431)1.91787973
98Generalized tonic-clonic seizures (HP:0002069)1.91760835
99Cerebral hemorrhage (HP:0001342)1.90583574
100Preaxial foot polydactyly (HP:0001841)1.89142413
101Macroorchidism (HP:0000053)1.88938632
102Impaired social interactions (HP:0000735)1.88444411
103Abnormal social behavior (HP:0012433)1.88444411
104Hyporeflexia of lower limbs (HP:0002600)1.87147480
105Poor eye contact (HP:0000817)1.86936061
106Hammertoe (HP:0001765)1.86520726
107Abnormality of binocular vision (HP:0011514)1.86189315
108Diplopia (HP:0000651)1.86189315
109Paraparesis (HP:0002385)1.86087552
110Metabolic alkalosis (HP:0200114)1.85859635
111Foot dorsiflexor weakness (HP:0009027)1.85106502
112Hemiplegia (HP:0002301)1.85006636
113Abnormal eating behavior (HP:0100738)1.83563532
114Morphological abnormality of the pyramidal tract (HP:0002062)1.83420299
115Abnormal respiratory motile cilium physiology (HP:0012261)1.82808336
116Rigidity (HP:0002063)1.82373187
117Increased nuchal translucency (HP:0010880)1.80998758
118Distal sensory impairment (HP:0002936)1.80863228
119Abnormality of the periventricular white matter (HP:0002518)1.80749761
120Oligodactyly (HP:0012165)1.80314252
121Hypsarrhythmia (HP:0002521)1.80214049
122Abnormal large intestine physiology (HP:0012700)1.79713698
123Absence seizures (HP:0002121)1.79436538
124Urinary incontinence (HP:0000020)1.78392792
125EEG with generalized epileptiform discharges (HP:0011198)1.78359441
126Choroideremia (HP:0001139)1.77996870
127Parakeratosis (HP:0001036)1.77959594
128Morphological abnormality of the inner ear (HP:0011390)1.77394667
129Overriding aorta (HP:0002623)1.77281037
130Turricephaly (HP:0000262)1.76674501
131Axonal loss (HP:0003447)1.76346003
132Partial duplication of the phalanx of hand (HP:0009999)1.76113265
133Segmental peripheral demyelination/remyelination (HP:0003481)1.76094195
134Nephronophthisis (HP:0000090)1.75947549
135Epileptiform EEG discharges (HP:0011182)1.75920708
136Absent speech (HP:0001344)1.73667393
137Status epilepticus (HP:0002133)1.73391812
138Humeroradial synostosis (HP:0003041)1.72701217
139Supernumerary spleens (HP:0009799)1.72641462
140Neoplasm of the oral cavity (HP:0100649)1.72628735
141Gastroesophageal reflux (HP:0002020)1.70427782
142Volvulus (HP:0002580)1.67205708
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66909511
144Limb dystonia (HP:0002451)1.65547536
145Broad thumb (HP:0011304)1.65065481
146Abnormality of the 4th metacarpal (HP:0010012)1.64843025
147Cerebellar dysplasia (HP:0007033)1.62410632
148Urethral obstruction (HP:0000796)1.62332969
149Glioma (HP:0009733)1.61966532
150Abnormality of chromosome segregation (HP:0002916)1.61399237
151Abnormality of the astrocytes (HP:0100707)1.60750748
152Astrocytoma (HP:0009592)1.60750748
153Renovascular hypertension (HP:0100817)1.59791329
154Duplication of thumb phalanx (HP:0009942)1.58337411

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.05825433
2STK394.04197017
3EPHA42.93486200
4OXSR12.78706131
5PRKD32.39491705
6EPHB12.35982334
7PAK62.15835013
8NTRK32.15672962
9NTRK12.13263738
10PKN12.09695542
11ICK2.04696451
12WEE11.90969188
13MAP3K91.87119644
14MARK11.84728659
15TYRO31.77755986
16FGFR21.77105394
17WNK11.75605544
18NTRK21.70109253
19WNK41.62863516
20BCR1.60412236
21CAMK1D1.59659196
22SGK21.54397739
23NEK61.54084079
24TNIK1.53979603
25PLK21.46643363
26UHMK11.44802256
27KSR21.42463081
28SGK4941.40789242
29SGK2231.40789242
30MAPK151.40558734
31CDK191.39439113
32MAP3K131.37814068
33PNCK1.34533975
34TSSK61.30204105
35ROCK21.29542803
36PHKG11.29290158
37PHKG21.29290158
38MKNK21.28828139
39MET1.28100582
40CDK51.27767840
41BRSK21.20465417
42CAMK2B1.20460300
43MINK11.17959805
44FGR1.15568235
45CDK121.11295707
46ZAK1.07987523
47DYRK1A1.06110747
48PAK31.05712439
49PRKCH1.04497125
50TTK1.04101002
51MAP3K41.02181241
52DAPK21.00419910
53STK38L1.00217854
54FRK0.99179743
55CDK30.98798260
56MAPKAPK50.98689099
57CSNK1A1L0.98578450
58RIPK40.97346590
59CAMK2D0.96955958
60PTK2B0.95804764
61CDC70.95728843
62CAMK1G0.95049043
63KSR10.94887201
64CASK0.94406922
65WNK30.93611135
66PDPK10.91919835
67CAMK2A0.90825271
68CSNK1G20.90163176
69CAMK10.86795973
70DYRK20.85240149
71BRSK10.84322789
72LMTK20.84230037
73CAMK2G0.83468786
74MKNK10.83394794
75DMPK0.82899572
76MAP3K20.82572016
77FES0.80748054
78CDK150.80504638
79PLK40.79985041
80CDK140.79614727
81PINK10.78698476
82CSNK1G30.78304821
83CDK180.77779801
84DDR20.77221524
85MARK20.77137129
86STK110.75918330
87BMX0.75287470
88PDK10.74857068
89CAMKK10.74693176
90BRD40.72530501
91ERBB20.72267139
92LIMK10.69059076
93PRKCQ0.68020246
94PRKD10.67897960
95CDK11A0.66923258
96LATS20.66445889
97EEF2K0.64757590
98BMPR1B0.64738583
99VRK10.64092714
100SIK20.63893263
101CLK10.63413394
102PLK30.62830625
103FGFR10.62628223
104PRKCE0.61252648
105FYN0.61133260
106SGK10.58434872
107SGK30.57021451
108LATS10.56032597
109CSNK1G10.55879397
110PDGFRB0.55088532
111PRKDC0.54832254
112PRKCG0.54642556
113RET0.54449327
114MAP3K100.54347076
115* GSK3B0.53402980
116PRKCZ0.52695195
117CSNK1E0.51829639
118STK380.51807108
119ATM0.51398795
120IRAK20.51354414
121PDK20.48463698
122CDC42BPA0.47606905
123MAP2K40.47528755
124MAP2K70.47286286
125CAMK40.46625832
126MAPK130.46585902
127ROCK10.46159763
128CDK10.44238176
129TAF10.43957254
130ATR0.43483870
131ALK0.43318118
132NLK0.42897376
133TNK20.42801984
134CHEK20.41878810
135CSNK1D0.41471284
136CDK20.41268735
137GSK3A0.41108452
138MAPK100.40430130
139PBK0.40347635
140PRKD20.40283035
141MAP3K70.39964616
142RPS6KA30.39917404
143PDK30.39393745
144PDK40.39393745
145PRKG10.38430121

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.33434908
2Glutamatergic synapse_Homo sapiens_hsa047242.12096266
3GABAergic synapse_Homo sapiens_hsa047272.11630677
4Nicotine addiction_Homo sapiens_hsa050331.98254411
5Circadian entrainment_Homo sapiens_hsa047131.89482454
6Morphine addiction_Homo sapiens_hsa050321.86667318
7Synaptic vesicle cycle_Homo sapiens_hsa047211.79942040
8Olfactory transduction_Homo sapiens_hsa047401.71620408
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71125698
10Salivary secretion_Homo sapiens_hsa049701.70006727
11Axon guidance_Homo sapiens_hsa043601.64506869
12Gastric acid secretion_Homo sapiens_hsa049711.60763586
13Histidine metabolism_Homo sapiens_hsa003401.60751153
14Steroid biosynthesis_Homo sapiens_hsa001001.55667842
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55154283
16Fatty acid elongation_Homo sapiens_hsa000621.54375154
17Long-term potentiation_Homo sapiens_hsa047201.52429056
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52418051
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.50157281
20Dorso-ventral axis formation_Homo sapiens_hsa043201.45383323
21Amphetamine addiction_Homo sapiens_hsa050311.44522298
22Cocaine addiction_Homo sapiens_hsa050301.44100542
23Long-term depression_Homo sapiens_hsa047301.34333010
24Fatty acid biosynthesis_Homo sapiens_hsa000611.34023112
25Dopaminergic synapse_Homo sapiens_hsa047281.33419899
26Cholinergic synapse_Homo sapiens_hsa047251.30463819
27Lysine degradation_Homo sapiens_hsa003101.30375754
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27486177
29Ether lipid metabolism_Homo sapiens_hsa005651.27198795
30Renin secretion_Homo sapiens_hsa049241.26577247
31Insulin secretion_Homo sapiens_hsa049111.25841056
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24342111
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22901163
34Serotonergic synapse_Homo sapiens_hsa047261.21250465
35beta-Alanine metabolism_Homo sapiens_hsa004101.18995023
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17661841
37Hippo signaling pathway_Homo sapiens_hsa043901.17454447
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16988497
39Basal cell carcinoma_Homo sapiens_hsa052171.16737174
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15657555
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13096863
42Gap junction_Homo sapiens_hsa045401.11433991
43Wnt signaling pathway_Homo sapiens_hsa043101.11263737
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10791080
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.10376489
46Oocyte meiosis_Homo sapiens_hsa041141.08194693
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06561527
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06124061
49Vitamin B6 metabolism_Homo sapiens_hsa007501.05994483
50cAMP signaling pathway_Homo sapiens_hsa040241.03844753
51Oxytocin signaling pathway_Homo sapiens_hsa049211.02801633
52ErbB signaling pathway_Homo sapiens_hsa040121.01357505
53Taste transduction_Homo sapiens_hsa047421.01299530
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99936488
55Linoleic acid metabolism_Homo sapiens_hsa005910.95610639
56Calcium signaling pathway_Homo sapiens_hsa040200.93928282
57mRNA surveillance pathway_Homo sapiens_hsa030150.92032832
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.91097653
59Renal cell carcinoma_Homo sapiens_hsa052110.91081863
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87598104
61Bile secretion_Homo sapiens_hsa049760.86707550
62GnRH signaling pathway_Homo sapiens_hsa049120.86060706
63Fanconi anemia pathway_Homo sapiens_hsa034600.85940104
64Estrogen signaling pathway_Homo sapiens_hsa049150.85787489
65Type II diabetes mellitus_Homo sapiens_hsa049300.85744166
66Alcoholism_Homo sapiens_hsa050340.84732277
67Hedgehog signaling pathway_Homo sapiens_hsa043400.83093464
68Pancreatic secretion_Homo sapiens_hsa049720.82784050
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.82418643
70Endocytosis_Homo sapiens_hsa041440.81501013
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81382568
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78471669
73Melanogenesis_Homo sapiens_hsa049160.76346371
74Circadian rhythm_Homo sapiens_hsa047100.76276322
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74564477
76Butanoate metabolism_Homo sapiens_hsa006500.74413154
77Ras signaling pathway_Homo sapiens_hsa040140.74252776
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71606916
79Homologous recombination_Homo sapiens_hsa034400.71256612
80Tight junction_Homo sapiens_hsa045300.71180135
81Phototransduction_Homo sapiens_hsa047440.70798773
82Sphingolipid metabolism_Homo sapiens_hsa006000.70730257
83Dilated cardiomyopathy_Homo sapiens_hsa054140.70039063
84Glioma_Homo sapiens_hsa052140.69784149
85Collecting duct acid secretion_Homo sapiens_hsa049660.69612618
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69597806
87Choline metabolism in cancer_Homo sapiens_hsa052310.68936433
88Fatty acid metabolism_Homo sapiens_hsa012120.68476440
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66620047
90Adherens junction_Homo sapiens_hsa045200.66344186
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65277761
92MAPK signaling pathway_Homo sapiens_hsa040100.63858627
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63191317
94Cardiac muscle contraction_Homo sapiens_hsa042600.63166980
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.61994417
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61051439
97Cell cycle_Homo sapiens_hsa041100.60990458
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60959169
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.60513433
100Arginine biosynthesis_Homo sapiens_hsa002200.58915262
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58227549
102Inositol phosphate metabolism_Homo sapiens_hsa005620.58115664
103Thyroid hormone synthesis_Homo sapiens_hsa049180.56523839
104Endometrial cancer_Homo sapiens_hsa052130.55481506
105Propanoate metabolism_Homo sapiens_hsa006400.55379536
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.54788139
107Ovarian steroidogenesis_Homo sapiens_hsa049130.54776026
108Mineral absorption_Homo sapiens_hsa049780.54630315
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53572103
110Vibrio cholerae infection_Homo sapiens_hsa051100.53054176
111ABC transporters_Homo sapiens_hsa020100.53003854
112Selenocompound metabolism_Homo sapiens_hsa004500.53002607
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51851779
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51632475
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51193071
116Chemokine signaling pathway_Homo sapiens_hsa040620.50936843
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50750304
118Sulfur metabolism_Homo sapiens_hsa009200.50294812
119Prion diseases_Homo sapiens_hsa050200.50125023
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50009462
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49381775
122Rap1 signaling pathway_Homo sapiens_hsa040150.49261863
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48285012
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47884699
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44998216
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42681276
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41937110
128VEGF signaling pathway_Homo sapiens_hsa043700.39330323
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.38484183
130Arginine and proline metabolism_Homo sapiens_hsa003300.38406618
131PPAR signaling pathway_Homo sapiens_hsa033200.38191847

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