PHLPP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.90582169
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.52849215
3regulation of guanylate cyclase activity (GO:0031282)5.28760998
4vocalization behavior (GO:0071625)5.27445055
5locomotory exploration behavior (GO:0035641)5.21432007
6synaptic vesicle maturation (GO:0016188)5.16783075
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.11328640
8glutamate secretion (GO:0014047)4.98533293
9angiotensin maturation (GO:0002003)4.96624484
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.92463224
11intestinal absorption (GO:0050892)4.69692114
12synaptic vesicle exocytosis (GO:0016079)4.65408112
13regulation of synaptic vesicle exocytosis (GO:2000300)4.63385233
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.54645959
15fucose catabolic process (GO:0019317)4.48439066
16L-fucose metabolic process (GO:0042354)4.48439066
17L-fucose catabolic process (GO:0042355)4.48439066
18protein localization to synapse (GO:0035418)4.43275819
19positive regulation of guanylate cyclase activity (GO:0031284)4.40728822
20regulation of glutamate receptor signaling pathway (GO:1900449)4.40511945
21cellular potassium ion homeostasis (GO:0030007)4.07432048
22layer formation in cerebral cortex (GO:0021819)4.07223713
23regulation of synaptic vesicle transport (GO:1902803)4.04437455
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.03727406
25sulfate transmembrane transport (GO:1902358)4.03437071
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.03396762
27proline transport (GO:0015824)3.99918124
28exploration behavior (GO:0035640)3.98018563
29neuron cell-cell adhesion (GO:0007158)3.93165292
30glutamate receptor signaling pathway (GO:0007215)3.91581570
31epoxygenase P450 pathway (GO:0019373)3.91085411
32neurotransmitter secretion (GO:0007269)3.84744943
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.77150476
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.74460653
35regulation of neuronal synaptic plasticity (GO:0048168)3.72886070
36neurotransmitter-gated ion channel clustering (GO:0072578)3.72820319
37regulation of bile acid biosynthetic process (GO:0070857)3.71079427
38cerebellar Purkinje cell differentiation (GO:0021702)3.70245424
39synaptic vesicle endocytosis (GO:0048488)3.69674111
40sodium ion export (GO:0071436)3.69397059
41flavonoid metabolic process (GO:0009812)3.68248227
42regulation of clathrin-mediated endocytosis (GO:2000369)3.66001797
43cellular glucuronidation (GO:0052695)3.64317189
44intestinal epithelial cell development (GO:0060576)3.62785236
45synaptic transmission, glutamatergic (GO:0035249)3.61218574
46regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.60947603
47dendritic spine morphogenesis (GO:0060997)3.60308887
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.56414305
49lipoprotein transport (GO:0042953)3.52954400
50long-term memory (GO:0007616)3.50203713
51bile acid and bile salt transport (GO:0015721)3.48227889
52sulfate transport (GO:0008272)3.47369288
53positive regulation of fatty acid beta-oxidation (GO:0032000)3.44623420
54neuron-neuron synaptic transmission (GO:0007270)3.44397247
55glucuronate metabolic process (GO:0019585)3.44294472
56uronic acid metabolic process (GO:0006063)3.44294472
57response to histamine (GO:0034776)3.41641078
58regulation of pigment cell differentiation (GO:0050932)3.39314131
59purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.37646808
603-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.37646808
61sulfation (GO:0051923)3.35344416
62alkaloid metabolic process (GO:0009820)3.33574596
63positive regulation of synapse maturation (GO:0090129)3.33222252
64neurotransmitter transport (GO:0006836)3.31037068
65positive regulation of membrane potential (GO:0045838)3.30496601
66serotonin metabolic process (GO:0042428)3.29971591
67neuron recognition (GO:0008038)3.25771894
68regulation of excitatory postsynaptic membrane potential (GO:0060079)3.25371431
69cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25126797
70regulation of cGMP biosynthetic process (GO:0030826)3.23792928
71regulation of postsynaptic membrane potential (GO:0060078)3.23710646
72gamma-aminobutyric acid transport (GO:0015812)3.22198049
73kidney morphogenesis (GO:0060993)3.21853360
74regulation of protein glycosylation (GO:0060049)3.19844080
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19406832
76axonal fasciculation (GO:0007413)3.19206593
77regulation of neurotransmitter secretion (GO:0046928)3.17481805
78membrane hyperpolarization (GO:0060081)3.16792575
79membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15800802
80long-term synaptic potentiation (GO:0060291)3.15019999
81primary amino compound metabolic process (GO:1901160)3.14980776
82membrane depolarization during action potential (GO:0086010)3.13824895
83vesicle transport along microtubule (GO:0047496)3.12918232
84positive regulation of neurotransmitter transport (GO:0051590)3.12323490
85positive regulation of neurotransmitter secretion (GO:0001956)3.11781807
86regulation of establishment of cell polarity (GO:2000114)3.11056346
87cytoplasmic mRNA processing body assembly (GO:0033962)3.10267992
88regulation of hippo signaling (GO:0035330)3.09661258
89activation of protein kinase A activity (GO:0034199)3.08988988
90drug catabolic process (GO:0042737)3.08691670
91cell communication by electrical coupling (GO:0010644)3.07275278
92neuronal action potential propagation (GO:0019227)3.06066067
93response to auditory stimulus (GO:0010996)3.06006804
94piRNA metabolic process (GO:0034587)3.05926237
95fat-soluble vitamin biosynthetic process (GO:0042362)3.05893650
96drug metabolic process (GO:0017144)3.04693050
97glycine transport (GO:0015816)3.03847373
98regulation of synaptic plasticity (GO:0048167)3.03105173
99regulation of synapse structural plasticity (GO:0051823)3.02523853
100regulation of systemic arterial blood pressure (GO:0003073)3.01449895
101dendrite morphogenesis (GO:0048813)3.00939241
102regulation of synaptic transmission, glutamatergic (GO:0051966)2.99555182
103innervation (GO:0060384)2.99408710
104positive regulation of glycoprotein biosynthetic process (GO:0010560)2.98738546
105G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.94840022
106negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94814038
107UDP-N-acetylglucosamine metabolic process (GO:0006047)2.93437127
108regulation of vesicle fusion (GO:0031338)2.93041906
109gamma-aminobutyric acid signaling pathway (GO:0007214)2.91844953
110regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.91753712
111endocrine process (GO:0050886)2.91753712
112regulation of systemic arterial blood pressure by hormone (GO:0001990)2.91753712
113digestion (GO:0007586)2.91183566
114heme transport (GO:0015886)2.90987033
115regulation of ARF protein signal transduction (GO:0032012)2.90193993
116positive regulation of fatty acid oxidation (GO:0046321)2.90171346
117auditory behavior (GO:0031223)2.89909629
118regulation of cGMP metabolic process (GO:0030823)2.89068567
119neuromuscular process controlling balance (GO:0050885)2.87736445
120pericardium development (GO:0060039)2.87611678
121regulation of neurotransmitter transport (GO:0051588)2.87187228
122indolalkylamine metabolic process (GO:0006586)2.86534663
123regulation of neurotransmitter levels (GO:0001505)2.85732422
124regulation of dendritic spine morphogenesis (GO:0061001)2.84934635
125fucosylation (GO:0036065)2.83955428
126intraspecies interaction between organisms (GO:0051703)2.83738554
127social behavior (GO:0035176)2.83738554
128thalamus development (GO:0021794)2.83029714
129behavioral response to nicotine (GO:0035095)2.83019428
130membrane depolarization (GO:0051899)2.82770312
131regulation of rhodopsin mediated signaling pathway (GO:0022400)2.81417592
132positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.81270856
133regulation of establishment or maintenance of cell polarity (GO:0032878)2.80161388
134vitamin transmembrane transport (GO:0035461)2.80013838
135regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.79965111
136startle response (GO:0001964)2.76987110
137dopamine receptor signaling pathway (GO:0007212)2.76428614
138exogenous drug catabolic process (GO:0042738)2.75955261
139regulation of synapse maturation (GO:0090128)2.75376863
140postsynaptic membrane organization (GO:0001941)2.74688728
141rhodopsin mediated signaling pathway (GO:0016056)2.74480871
142positive regulation of synaptic transmission, GABAergic (GO:0032230)2.74431122
143establishment of protein localization to Golgi (GO:0072600)2.74424570
144membrane repolarization (GO:0086009)2.74112678
145negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72129856
146cellular sodium ion homeostasis (GO:0006883)2.70401364
147regulation of triglyceride catabolic process (GO:0010896)2.70043306
148establishment of nucleus localization (GO:0040023)2.69684501
149sulfur compound transport (GO:0072348)2.69189977
150indole-containing compound catabolic process (GO:0042436)2.69083633
151indolalkylamine catabolic process (GO:0046218)2.69083633
152tryptophan catabolic process (GO:0006569)2.69083633
153potassium ion import (GO:0010107)2.68827786
154membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.68369617
155positive regulation of synaptic transmission (GO:0050806)2.68301504
156regulation of action potential (GO:0098900)2.68170632
157synapse assembly (GO:0007416)2.67981315
158regulation of sarcomere organization (GO:0060297)2.67323449
159positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.67307465
160detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67258857
161auditory receptor cell differentiation (GO:0042491)2.67137375
162L-amino acid import (GO:0043092)2.66859912
163transmission of nerve impulse (GO:0019226)2.65970269
164potassium ion homeostasis (GO:0055075)2.65933462
165central nervous system projection neuron axonogenesis (GO:0021952)2.65475188
166righting reflex (GO:0060013)2.65250645
167inner ear receptor cell development (GO:0060119)2.65089796
168regulation of meiosis I (GO:0060631)2.64492797
169peptide hormone processing (GO:0016486)2.61375213
170behavioral response to ethanol (GO:0048149)2.60296620
171toxin metabolic process (GO:0009404)2.60120417
172positive regulation of cGMP biosynthetic process (GO:0030828)2.58608372
173somite rostral/caudal axis specification (GO:0032525)2.57179057
174sex differentiation (GO:0007548)2.55675537
175bile acid metabolic process (GO:0008206)2.51336061
176embryonic foregut morphogenesis (GO:0048617)2.46963080
177nodal signaling pathway (GO:0038092)2.45982134
178negative regulation of keratinocyte proliferation (GO:0010839)2.45862872
179DNA methylation involved in gamete generation (GO:0043046)2.45848545
180indole-containing compound metabolic process (GO:0042430)2.45332305
181vitamin A metabolic process (GO:0006776)2.45312301
182N-glycan processing (GO:0006491)2.43751186
183positive regulation of glycolytic process (GO:0045821)2.43000441
184regulation of developmental pigmentation (GO:0048070)2.41902492
185transepithelial transport (GO:0070633)2.41209904
186receptor guanylyl cyclase signaling pathway (GO:0007168)2.40687229
187signal transduction involved in regulation of gene expression (GO:0023019)2.38987963
188lipid translocation (GO:0034204)2.38480726
189phospholipid translocation (GO:0045332)2.38480726
190glycerol metabolic process (GO:0006071)2.37899547
191auditory receptor cell stereocilium organization (GO:0060088)2.37225542
192diacylglycerol metabolic process (GO:0046339)2.36250798
193sodium ion transport (GO:0006814)2.36124268
194kynurenine metabolic process (GO:0070189)2.35688912
195drug transmembrane transport (GO:0006855)2.35127795
196thyroid hormone metabolic process (GO:0042403)2.35084053
197protein targeting to Golgi (GO:0000042)2.34960455
198C4-dicarboxylate transport (GO:0015740)2.33899090
199neuronal action potential (GO:0019228)2.32577445

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.92222157
2GBX2_23144817_ChIP-Seq_PC3_Human3.48554955
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.02103481
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68800786
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59705328
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54165089
7DROSHA_22980978_ChIP-Seq_HELA_Human2.49677481
8VDR_22108803_ChIP-Seq_LS180_Human2.35613414
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31872522
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31872522
11REST_21632747_ChIP-Seq_MESCs_Mouse2.29929612
12FUS_26573619_Chip-Seq_HEK293_Human2.26192283
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25378797
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.22076742
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20255181
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16851282
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15985519
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14773119
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08838799
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04760330
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01203246
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.00440597
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.96219556
24ER_23166858_ChIP-Seq_MCF-7_Human1.93610752
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92313049
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88714705
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88509278
28* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87236105
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87196763
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.85738638
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.85278363
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.83595330
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82245499
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.78764407
35BCAT_22108803_ChIP-Seq_LS180_Human1.78416175
36AR_21572438_ChIP-Seq_LNCaP_Human1.76049316
37SMAD4_21799915_ChIP-Seq_A2780_Human1.74202298
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.72730910
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.70211366
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64529160
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60700465
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58016748
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57382794
44EWS_26573619_Chip-Seq_HEK293_Human1.52677737
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50195031
46STAT3_23295773_ChIP-Seq_U87_Human1.48564246
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47939728
48CDX2_22108803_ChIP-Seq_LS180_Human1.45007021
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43994588
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42899930
51* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41615996
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41444568
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40044338
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39870765
55* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39217365
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.38546579
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37895245
58CBP_20019798_ChIP-Seq_JUKART_Human1.37895245
59P300_19829295_ChIP-Seq_ESCs_Human1.35949869
60FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35252586
61TCF4_22108803_ChIP-Seq_LS180_Human1.34715595
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33668868
63AR_19668381_ChIP-Seq_PC3_Human1.33541304
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32107000
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32090579
66P53_22127205_ChIP-Seq_FIBROBLAST_Human1.30856039
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28351793
68TP53_16413492_ChIP-PET_HCT116_Human1.27006345
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26777988
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26729863
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.26550031
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25723691
73AR_25329375_ChIP-Seq_VCAP_Human1.25647718
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25116125
75RXR_22108803_ChIP-Seq_LS180_Human1.24979115
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24556597
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24508342
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24121215
79IGF1R_20145208_ChIP-Seq_DFB_Human1.23897583
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.23871604
81AHR_22903824_ChIP-Seq_MCF-7_Human1.22504440
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20603601
83* TCF4_23295773_ChIP-Seq_U87_Human1.20166422
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19819418
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19808982
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19619171
87EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18788878
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.17970755
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16386589
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16126178
91* KDM2B_26808549_Chip-Seq_K562_Human1.16036860
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15747158
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15324061
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13614045
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.13554754
96GATA4_25053715_ChIP-Seq_YYC3_Human1.13449425
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13115681
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.12895067
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12213277
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.12126608
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10859734
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10577395
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10490682
104GATA1_22025678_ChIP-Seq_K562_Human1.10010493
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08362100
106TAF15_26573619_Chip-Seq_HEK293_Human1.07948681
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.07591895
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07557896
109RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07459249
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06626394
111ZNF274_21170338_ChIP-Seq_K562_Hela1.06470949
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06219456
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.06174171
114POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05915835
115RING1B_27294783_Chip-Seq_NPCs_Mouse1.05801697
116ERG_21242973_ChIP-ChIP_JURKAT_Human1.05687025
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05438172
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05369792
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.05335468
120P53_22387025_ChIP-Seq_ESCs_Mouse1.05287128
121TP53_18474530_ChIP-ChIP_U2OS_Human1.04698057
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04627558
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04185126
124SMAD4_21741376_ChIP-Seq_HESCs_Human1.03745972
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02687802
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01999434
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01722471
128BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01703087
129TCF4_18268006_ChIP-ChIP_LS174T_Human1.01674636
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01557151
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01437636
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01437636
133MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01327112
134E2F1_18555785_Chip-Seq_ESCs_Mouse1.00902440
135RUNX2_22187159_ChIP-Seq_PCA_Human1.00795747
136RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00027646
137CBX2_27304074_Chip-Seq_ESCs_Mouse1.00008828
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.99582059
139KDM2B_26808549_Chip-Seq_REH_Human0.99378806
140WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99195700
141RNF2_27304074_Chip-Seq_NSC_Mouse0.99120055
142NANOG_18555785_Chip-Seq_ESCs_Mouse0.99025018
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.98821253
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97413231
145CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95272136
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94479996
147SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93379183
148DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92813707

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.16794298
2MP0005360_urolithiasis4.72401307
3MP0003880_abnormal_central_pattern4.05556281
4MP0005085_abnormal_gallbladder_physiolo3.95240049
5MP0003635_abnormal_synaptic_transmissio3.81288456
6MP0004270_analgesia3.52099475
7MP0004147_increased_porphyrin_level3.23081129
8MP0009745_abnormal_behavioral_response3.06314803
9MP0005423_abnormal_somatic_nervous3.04013631
10MP0002063_abnormal_learning/memory/cond2.96039367
11MP0009046_muscle_twitch2.94816766
12MP0001666_abnormal_nutrient_absorption2.91900003
13MP0008057_abnormal_DNA_replication2.87147059
14MP0002064_seizures2.86854275
15MP0001968_abnormal_touch/_nociception2.83340209
16MP0005365_abnormal_bile_salt2.66704901
17MP0005551_abnormal_eye_electrophysiolog2.62677561
18MP0000569_abnormal_digit_pigmentation2.61070772
19MP0002572_abnormal_emotion/affect_behav2.59017421
20MP0002734_abnormal_mechanical_nocicepti2.49610886
21MP0001486_abnormal_startle_reflex2.47771517
22MP0002139_abnormal_hepatobiliary_system2.45128327
23MP0003787_abnormal_imprinting2.36254970
24MP0004043_abnormal_pH_regulation2.27721396
25MP0003252_abnormal_bile_duct2.27149455
26MP0002909_abnormal_adrenal_gland2.16935156
27MP0002272_abnormal_nervous_system2.16046535
28MP0002736_abnormal_nociception_after2.10588128
29MP0009780_abnormal_chondrocyte_physiolo2.05147346
30MP0001501_abnormal_sleep_pattern2.04383596
31MP0003122_maternal_imprinting2.03237553
32MP0002822_catalepsy2.01263275
33MP0003868_abnormal_feces_composition2.00074644
34MP0002735_abnormal_chemical_nociception1.98229207
35MP0003195_calcinosis1.95302768
36MP0001440_abnormal_grooming_behavior1.90786808
37MP0004019_abnormal_vitamin_homeostasis1.90106433
38MP0004264_abnormal_extraembryonic_tissu1.85311266
39MP0002067_abnormal_sensory_capabilities1.84816966
40MP0000427_abnormal_hair_cycle1.78279138
41MP0002733_abnormal_thermal_nociception1.77599571
42MP0008569_lethality_at_weaning1.76928704
43MP0003879_abnormal_hair_cell1.76746416
44MP0000778_abnormal_nervous_system1.74981148
45MP0005386_behavior/neurological_phenoty1.71552248
46MP0004924_abnormal_behavior1.71552248
47MP0002557_abnormal_social/conspecific_i1.68774769
48MP0001485_abnormal_pinna_reflex1.68347361
49MP0001970_abnormal_pain_threshold1.65908570
50MP0000538_abnormal_urinary_bladder1.63505389
51MP0002184_abnormal_innervation1.63399260
52MP0006276_abnormal_autonomic_nervous1.61244729
53MP0005646_abnormal_pituitary_gland1.58057382
54MP0006072_abnormal_retinal_apoptosis1.55201888
55MP0004858_abnormal_nervous_system1.55014679
56MP0004811_abnormal_neuron_physiology1.54862100
57MP0000383_abnormal_hair_follicle1.54408800
58MP0003950_abnormal_plasma_membrane1.51368693
59MP0002102_abnormal_ear_morphology1.50917124
60MP0005253_abnormal_eye_physiology1.50017252
61MP0002882_abnormal_neuron_morphology1.49068920
62MP0003718_maternal_effect1.48452731
63MP0010329_abnormal_lipoprotein_level1.48122694
64MP0005310_abnormal_salivary_gland1.47120882
65MP0004885_abnormal_endolymph1.45617597
66MP0008875_abnormal_xenobiotic_pharmacok1.42854950
67MP0002938_white_spotting1.41481988
68MP0001873_stomach_inflammation1.37416058
69MP0001905_abnormal_dopamine_level1.34687705
70MP0002837_dystrophic_cardiac_calcinosis1.33861275
71MP0000955_abnormal_spinal_cord1.33209208
72MP0001502_abnormal_circadian_rhythm1.33122945
73MP0001764_abnormal_homeostasis1.33074766
74MP0003011_delayed_dark_adaptation1.32062544
75MP0010352_gastrointestinal_tract_polyps1.26150636
76MP0005174_abnormal_tail_pigmentation1.23282961
77MP0008961_abnormal_basal_metabolism1.22427761
78MP0002066_abnormal_motor_capabilities/c1.22245784
79MP0005645_abnormal_hypothalamus_physiol1.20288241
80MP0001188_hyperpigmentation1.20271931
81MP0002229_neurodegeneration1.19820114
82MP0003123_paternal_imprinting1.19062266
83MP0003183_abnormal_peptide_metabolism1.16700690
84MP0002009_preneoplasia1.14119430
85MP0003283_abnormal_digestive_organ1.11110910
86MP0005332_abnormal_amino_acid1.10516984
87MP0010678_abnormal_skin_adnexa1.10159346
88MP0003121_genomic_imprinting1.09085291
89MP0002152_abnormal_brain_morphology1.07969576
90MP0001984_abnormal_olfaction1.07429852
91MP0002090_abnormal_vision1.05143589
92MP0009379_abnormal_foot_pigmentation1.04340901
93MP0008872_abnormal_physiological_respon1.03400419
94MP0006292_abnormal_olfactory_placode1.02582241
95MP0003633_abnormal_nervous_system1.00400881
96MP0003937_abnormal_limbs/digits/tail_de0.99850332
97MP0002160_abnormal_reproductive_system0.98974608
98MP0001765_abnormal_ion_homeostasis0.98255813
99MP0003329_amyloid_beta_deposits0.97833360
100MP0003119_abnormal_digestive_system0.97269803
101MP0005448_abnormal_energy_balance0.97120092
102MP0005409_darkened_coat_color0.94872263
103MP0000230_abnormal_systemic_arterial0.93943836
104MP0002752_abnormal_somatic_nervous0.91682186
105MP0003045_fibrosis0.89652844
106MP0005195_abnormal_posterior_eye0.88553839
107MP0003631_nervous_system_phenotype0.86451985
108MP0004742_abnormal_vestibular_system0.86302525
109MP0005379_endocrine/exocrine_gland_phen0.86011784
110MP0001963_abnormal_hearing_physiology0.85880400
111MP0004142_abnormal_muscle_tone0.85294940
112MP0005394_taste/olfaction_phenotype0.82279860
113MP0005499_abnormal_olfactory_system0.82279860
114MP0005636_abnormal_mineral_homeostasis0.80246271
115MP0001986_abnormal_taste_sensitivity0.80047115
116MP0005187_abnormal_penis_morphology0.79728330
117MP0000462_abnormal_digestive_system0.79561904
118MP0001177_atelectasis0.79532247
119MP0004133_heterotaxia0.79057101
120MP0002118_abnormal_lipid_homeostasis0.78558608
121MP0000631_abnormal_neuroendocrine_gland0.78339305
122MP0010234_abnormal_vibrissa_follicle0.78301669
123MP0002069_abnormal_eating/drinking_beha0.78201384
124MP0003693_abnormal_embryo_hatching0.76599872
125MP0010386_abnormal_urinary_bladder0.75601750
126MP0004085_abnormal_heartbeat0.74691284
127MP0004215_abnormal_myocardial_fiber0.73114092
128MP0001348_abnormal_lacrimal_gland0.71392685
129MP0005171_absent_coat_pigmentation0.69327995
130MP0003172_abnormal_lysosome_physiology0.69166615
131MP0003698_abnormal_male_reproductive0.68616230
132MP0003634_abnormal_glial_cell0.68473485
133MP0003953_abnormal_hormone_level0.68388236
134MP0001299_abnormal_eye_distance/0.68143265
135MP0001529_abnormal_vocalization0.67511554
136MP0009643_abnormal_urine_homeostasis0.66758237
137MP0002098_abnormal_vibrissa_morphology0.66701065
138MP0005389_reproductive_system_phenotype0.66700090
139MP0003890_abnormal_embryonic-extraembry0.66422619
140MP0003136_yellow_coat_color0.66328931
141MP0000751_myopathy0.66314381
142MP0003866_abnormal_defecation0.66203513
143MP0005670_abnormal_white_adipose0.65859218
144MP0005535_abnormal_body_temperature0.64118924
145MP0002638_abnormal_pupillary_reflex0.64029098
146MP0003861_abnormal_nervous_system0.63385668
147MP0003632_abnormal_nervous_system0.63272270
148MP0001664_abnormal_digestion0.62468867
149MP0001943_abnormal_respiration0.60729765
150MP0008877_abnormal_DNA_methylation0.60696543
151MP0002876_abnormal_thyroid_physiology0.60694666
152MP0001324_abnormal_eye_pigmentation0.60037746
153MP0004233_abnormal_muscle_weight0.59348224
154MP0008874_decreased_physiological_sensi0.57230849
155MP0004510_myositis0.57199998
156MP0005623_abnormal_meninges_morphology0.56980789
157MP0002653_abnormal_ependyma_morphology0.56702062

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.90846642
2Abnormality of glutamine family amino acid metabolism (HP:0010902)5.17423943
3Focal seizures (HP:0007359)4.89725768
4Epileptic encephalopathy (HP:0200134)4.47164727
5Congenital stationary night blindness (HP:0007642)4.43981017
6Abnormality of proline metabolism (HP:0010907)4.29205323
7Hydroxyprolinuria (HP:0003080)4.29205323
8Visual hallucinations (HP:0002367)4.26732264
9Myokymia (HP:0002411)4.24225231
10Febrile seizures (HP:0002373)4.19213072
11Progressive cerebellar ataxia (HP:0002073)3.78894304
12Acanthocytosis (HP:0001927)3.58096677
13Central scotoma (HP:0000603)3.52275955
14Atonic seizures (HP:0010819)3.47847835
15Abnormality of vitamin B metabolism (HP:0004340)3.42748602
16Metabolic alkalosis (HP:0200114)3.42460552
17Hypobetalipoproteinemia (HP:0003563)3.42308581
18Abnormality of the vitamin B12 metabolism (HP:0004341)3.39081173
19Congenital sensorineural hearing impairment (HP:0008527)3.39019164
20Bony spicule pigmentary retinopathy (HP:0007737)3.37718489
21Action tremor (HP:0002345)3.37567991
22Absence seizures (HP:0002121)3.30368929
23Volvulus (HP:0002580)3.29874502
24Confusion (HP:0001289)3.23957598
25Generalized tonic-clonic seizures (HP:0002069)3.18171693
26Decreased circulating renin level (HP:0003351)3.12469146
27Broad-based gait (HP:0002136)3.08013930
28Dialeptic seizures (HP:0011146)2.99235183
29Hyperglycinuria (HP:0003108)2.97984962
30Ileus (HP:0002595)2.96988527
31Abnormality of macular pigmentation (HP:0008002)2.96366891
32Ankle clonus (HP:0011448)2.91036203
33Genetic anticipation (HP:0003743)2.87256836
34Chronic hepatic failure (HP:0100626)2.84654046
35Truncal ataxia (HP:0002078)2.81877306
36Hypothermia (HP:0002045)2.77846738
37Scotoma (HP:0000575)2.77507158
38Gaze-evoked nystagmus (HP:0000640)2.75097985
39Pigmentary retinal degeneration (HP:0001146)2.72936923
40Dysdiadochokinesis (HP:0002075)2.71827214
41Abnormal rod and cone electroretinograms (HP:0008323)2.70478418
42Urinary bladder sphincter dysfunction (HP:0002839)2.70005048
43Pheochromocytoma (HP:0002666)2.68882115
44Abnormality of renin-angiotensin system (HP:0000847)2.68636557
45Supranuclear gaze palsy (HP:0000605)2.67926334
46Depression (HP:0000716)2.65752845
47Impaired vibration sensation in the lower limbs (HP:0002166)2.64760702
48Abnormality of vitamin metabolism (HP:0100508)2.63432915
49Proximal tubulopathy (HP:0000114)2.62882287
50Abnormality of the renal cortex (HP:0011035)2.62602835
51Abnormality of ocular smooth pursuit (HP:0000617)2.55400685
52Impaired smooth pursuit (HP:0007772)2.50081254
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49129959
54Excessive salivation (HP:0003781)2.48759865
55Drooling (HP:0002307)2.48759865
56Insomnia (HP:0100785)2.47339583
57Impaired social interactions (HP:0000735)2.44694097
58Abnormal social behavior (HP:0012433)2.44694097
59Hyperactive renin-angiotensin system (HP:0000841)2.44683924
60Dyschromatopsia (HP:0007641)2.44603683
61Poor eye contact (HP:0000817)2.43777798
62Abnormal biliary tract morphology (HP:0012440)2.42947271
63Papilledema (HP:0001085)2.42550784
64Fat malabsorption (HP:0002630)2.38569234
65Facial shape deformation (HP:0011334)2.37748664
66Potter facies (HP:0002009)2.37748664
67Chorioretinal atrophy (HP:0000533)2.34762281
68Pancreatic cysts (HP:0001737)2.34726383
69Mutism (HP:0002300)2.33586753
70Malnutrition (HP:0004395)2.33254980
71Abnormality of the lower motor neuron (HP:0002366)2.33063960
72Abnormality of chloride homeostasis (HP:0011422)2.31978538
73Dysmetria (HP:0001310)2.31237967
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.28563444
75Postural instability (HP:0002172)2.26896017
76Abnormality of serine family amino acid metabolism (HP:0010894)2.25427994
77Abnormality of glycine metabolism (HP:0010895)2.25427994
78Cerebellar dysplasia (HP:0007033)2.24121418
79Hyperventilation (HP:0002883)2.23904623
80Chronic diarrhea (HP:0002028)2.21946830
81Hemiplegia (HP:0002301)2.21765137
82Renal cortical cysts (HP:0000803)2.21320382
83Chromsome breakage (HP:0040012)2.21244863
84Macroorchidism (HP:0000053)2.20649006
85Aqueductal stenosis (HP:0002410)2.18446875
86Absent speech (HP:0001344)2.18298044
87Amblyopia (HP:0000646)2.17735813
88Inappropriate behavior (HP:0000719)2.17316006
89Fair hair (HP:0002286)2.15548596
90Dysmetric saccades (HP:0000641)2.14653306
91Epileptiform EEG discharges (HP:0011182)2.10403337
92Alkalosis (HP:0001948)2.09399059
93Abnormal eating behavior (HP:0100738)2.09360295
94Hemiparesis (HP:0001269)2.09027324
95Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08034161
96Widely patent fontanelles and sutures (HP:0004492)2.04927117
97Decreased central vision (HP:0007663)2.04193598
98Termporal pattern (HP:0011008)2.03638765
99Insidious onset (HP:0003587)2.03638765
100Degeneration of the lateral corticospinal tracts (HP:0002314)2.03378852
101Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.03378852
102Anxiety (HP:0000739)2.03151645
103Hypoalbuminemia (HP:0003073)2.01015816
104Abnormal albumin level (HP:0012116)2.01015816
105EEG with generalized epileptiform discharges (HP:0011198)2.00979801
106Abnormality of binocular vision (HP:0011514)1.99835185
107Diplopia (HP:0000651)1.99835185
108Abnormality of chromosome stability (HP:0003220)1.99789587
109Limb hypertonia (HP:0002509)1.99004435
110Inability to walk (HP:0002540)1.98459873
111Lower limb amyotrophy (HP:0007210)1.98138937
112Abnormality of potassium homeostasis (HP:0011042)1.97744737
113Hyperaldosteronism (HP:0000859)1.97543376
114Birth length less than 3rd percentile (HP:0003561)1.96177418
115Choroideremia (HP:0001139)1.96076533
116Abolished electroretinogram (ERG) (HP:0000550)1.96036582
117Pendular nystagmus (HP:0012043)1.95907068
118Neuroendocrine neoplasm (HP:0100634)1.94637562
119Type II diabetes mellitus (HP:0005978)1.94635824
120Urethral obstruction (HP:0000796)1.94542281
121Nephronophthisis (HP:0000090)1.94169254
122Stereotypic behavior (HP:0000733)1.93077471
123Urinary urgency (HP:0000012)1.92060457
124Glycosuria (HP:0003076)1.91788584
125Abnormality of urine glucose concentration (HP:0011016)1.91788584
126Megaloblastic anemia (HP:0001889)1.91352341
127Pointed chin (HP:0000307)1.89734573
128Tubular atrophy (HP:0000092)1.88919355
129Abnormal biliary tract physiology (HP:0012439)1.88254286
130Bile duct proliferation (HP:0001408)1.88254286
131Bradykinesia (HP:0002067)1.88196229
132Abnormality of the nasal septum (HP:0000419)1.87827120
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.87735685
134Bilateral microphthalmos (HP:0007633)1.87458914
135Lower limb muscle weakness (HP:0007340)1.86663284
136Type II lissencephaly (HP:0007260)1.86022915
137Hypsarrhythmia (HP:0002521)1.85692387
138Abnormality of the renal medulla (HP:0100957)1.85307765
139Elfin facies (HP:0004428)1.85270088
140Ventricular fibrillation (HP:0001663)1.84793317
141Limb dystonia (HP:0002451)1.84667756
142Midline defect of the nose (HP:0004122)1.82754579
143Hyperacusis (HP:0010780)1.82610313
144Clumsiness (HP:0002312)1.81991832
145Spastic gait (HP:0002064)1.80104790
146Biliary tract neoplasm (HP:0100574)1.79527593
147Large for gestational age (HP:0001520)1.79357953
148Photophobia (HP:0000613)1.78636509
149Hypoventilation (HP:0002791)1.78025046
150Poikilocytosis (HP:0004447)1.77723162
151Enlarged epiphyses (HP:0010580)1.77440760
152Progressive sensorineural hearing impairment (HP:0000408)1.76913972
153Blue irides (HP:0000635)1.76874274
154Abdominal distention (HP:0003270)1.76812814
155Progressive inability to walk (HP:0002505)1.76693912
156Hyperkalemia (HP:0002153)1.76679318
157Megalencephaly (HP:0001355)1.75899041
158Macular degeneration (HP:0000608)1.75409885
159Clubbing of toes (HP:0100760)1.73568221
160True hermaphroditism (HP:0010459)1.73304923
161Impaired vibratory sensation (HP:0002495)1.73299912
162Hypokalemia (HP:0002900)1.71299968
163Intention tremor (HP:0002080)1.70863149
164Open mouth (HP:0000194)1.70617095
165Absent radius (HP:0003974)1.70604119
166Widely spaced teeth (HP:0000687)1.66900755
167Abnormality of salivation (HP:0100755)1.65718609
168Protruding tongue (HP:0010808)1.65080361
169Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.64008347
170Horizontal nystagmus (HP:0000666)1.63607795
171Ankyloglossia (HP:0010296)1.63033196
172Abnormal hair whorl (HP:0010721)1.62924015
173Obsessive-compulsive behavior (HP:0000722)1.61905829
174Attenuation of retinal blood vessels (HP:0007843)1.58798435
175Status epilepticus (HP:0002133)1.58577962
176Fetal akinesia sequence (HP:0001989)1.58517761
177Abnormality of the corticospinal tract (HP:0002492)1.58496354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.02996946
2NTRK34.78117045
3MAP3K93.64290477
4MAP3K43.32426212
5EPHA43.04512872
6STK38L2.85326575
7MARK12.79033639
8MAP2K72.57796392
9DAPK22.22446564
10SIK22.17259760
11PIK3CA2.15960032
12MINK12.15876428
13ADRBK22.12096166
14OXSR12.11858009
15STK392.11360271
16BMPR1B2.07791739
17NTRK22.04583025
18PRKD32.03383388
19PAK61.97439622
20MAP3K121.87613097
21PBK1.84556565
22WNK41.84154090
23MAP2K41.81791211
24RIPK41.81029283
25MET1.80342060
26MST1R1.66226696
27PRPF4B1.66121992
28LMTK21.58226450
29MAPK131.53227010
30KSR21.52624440
31STK381.50290718
32KSR11.49061720
33MELK1.47488059
34ZAK1.46912526
35CASK1.46005764
36CAMKK11.43678604
37PLK21.43306254
38TAOK11.42592805
39CDK51.38419808
40GRK51.35688334
41NTRK11.35028082
42CDK121.32128796
43MAP3K21.24185482
44LATS21.23414386
45SGK31.22080238
46STK31.21955489
47TAF11.20902273
48MAP3K101.20735279
49SGK21.20331914
50NLK1.18776330
51BRD41.13406434
52FES1.13085609
53MKNK21.11388909
54PINK11.10650725
55RET1.09748839
56EIF2AK31.08567454
57TNIK1.07598034
58WNK31.07243624
59FRK1.07174343
60CAMK1G1.06736583
61CCNB11.06170379
62TLK11.03921674
63MAP3K131.03296657
64SGK4941.02421822
65SGK2231.02421822
66DAPK11.00167213
67TYRO30.97756078
68SGK10.97315976
69PRKCH0.97065859
70AKT30.97036642
71PRKG20.92831553
72INSRR0.91418530
73RIPK10.89315808
74STK110.88440896
75SIK30.87502020
76PRKCE0.83872153
77CDC42BPA0.81405196
78MUSK0.80301260
79PRKCG0.79923867
80CAMK2A0.77604038
81GRK10.75827853
82ALK0.75491714
83NUAK10.74095021
84CAMK10.73985147
85FGR0.73940339
86WNK10.71621292
87STK240.69153856
88CAMKK20.68775238
89BRSK20.68151898
90FGFR20.66670494
91MAP3K60.65214773
92CAMK1D0.64700233
93PAK30.64695810
94TRIM280.62812284
95PTK2B0.62164134
96MAPKAPK50.62013913
97PRKAA20.61408324
98PNCK0.60857049
99TAOK20.60815671
100BCR0.60122086
101RPS6KA30.59472501
102CDK180.59318278
103MAP2K20.58505463
104CDK150.57932752
105JAK10.57255637
106DYRK1A0.56150458
107CAMK2D0.55291649
108LATS10.55233646
109BMPR20.54509695
110CSNK1G20.54371999
111MAP4K20.53709046
112CHUK0.53400786
113MAPK100.52559438
114DDR20.52214895
115MAP3K10.51144350
116RPS6KB10.50510239
117ERBB20.50449630
118PHKG20.50083141
119PHKG10.50083141
120CDK140.49709227
121PRKAA10.48979309
122PDK10.48940242
123PRKCZ0.48716651
124TNK20.48268139
125MARK20.47763561
126CDK11A0.47078839
127PDGFRA0.47047618
128FER0.46905514
129MAP3K70.46310447
130CSNK1A10.43220445
131FYN0.42782628
132NEK60.41933271
133CAMK40.40996478
134PRKCB0.40961628
135UHMK10.40889720
136SCYL20.40328877
137ADRBK10.40294313
138PDPK10.39171918
139ERBB30.38841250
140NEK20.37801723
141MAP2K10.36942531
142CAMK2B0.36799910
143GSK3B0.36773937
144PDGFRB0.36494412
145BMX0.36493826
146NEK10.35797571
147PIM10.35561187
148RPS6KA20.35292424
149CSNK1D0.32626166
150PLK40.29533383
151PRKCA0.29083999
152CHEK20.28909730
153ATM0.28677590
154EPHA20.28293687
155TAOK30.26896961

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.37225501
2Phototransduction_Homo sapiens_hsa047443.13300003
3Vitamin digestion and absorption_Homo sapiens_hsa049773.12245620
4Nicotine addiction_Homo sapiens_hsa050333.02094964
5Fat digestion and absorption_Homo sapiens_hsa049752.94867218
6Caffeine metabolism_Homo sapiens_hsa002322.90603104
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.87907222
8Synaptic vesicle cycle_Homo sapiens_hsa047212.87308825
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.75134464
10Circadian entrainment_Homo sapiens_hsa047132.40417119
11Olfactory transduction_Homo sapiens_hsa047402.35852785
12GABAergic synapse_Homo sapiens_hsa047272.30250519
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.29034191
14Glutamatergic synapse_Homo sapiens_hsa047242.28210972
15Long-term potentiation_Homo sapiens_hsa047202.24987457
16Histidine metabolism_Homo sapiens_hsa003402.15788622
17Morphine addiction_Homo sapiens_hsa050322.13716811
18Linoleic acid metabolism_Homo sapiens_hsa005912.01427871
19Tryptophan metabolism_Homo sapiens_hsa003801.99394190
20Amphetamine addiction_Homo sapiens_hsa050311.97655880
21Nitrogen metabolism_Homo sapiens_hsa009101.93801447
22Dopaminergic synapse_Homo sapiens_hsa047281.93794630
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93365832
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.93039350
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89547103
26Cholinergic synapse_Homo sapiens_hsa047251.87572332
27Retinol metabolism_Homo sapiens_hsa008301.87515755
28Salivary secretion_Homo sapiens_hsa049701.85290879
29Insulin secretion_Homo sapiens_hsa049111.84491301
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76604970
31Protein digestion and absorption_Homo sapiens_hsa049741.69467017
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69064514
33Gastric acid secretion_Homo sapiens_hsa049711.68889950
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66045099
35Renin secretion_Homo sapiens_hsa049241.65166915
36Cocaine addiction_Homo sapiens_hsa050301.57493819
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53532767
38Taste transduction_Homo sapiens_hsa047421.52746652
39Type II diabetes mellitus_Homo sapiens_hsa049301.52396063
40Serotonergic synapse_Homo sapiens_hsa047261.51952190
41Chemical carcinogenesis_Homo sapiens_hsa052041.49420059
42GnRH signaling pathway_Homo sapiens_hsa049121.48851552
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48790033
44Oxytocin signaling pathway_Homo sapiens_hsa049211.47682640
45Butanoate metabolism_Homo sapiens_hsa006501.47476571
46Long-term depression_Homo sapiens_hsa047301.46804323
47Starch and sucrose metabolism_Homo sapiens_hsa005001.43523187
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42450840
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.37769349
50Calcium signaling pathway_Homo sapiens_hsa040201.33254797
51Ether lipid metabolism_Homo sapiens_hsa005651.30835924
52ABC transporters_Homo sapiens_hsa020101.26831402
53Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24296232
54Gap junction_Homo sapiens_hsa045401.22541813
55Glioma_Homo sapiens_hsa052141.22492393
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21766774
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19917504
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19554700
59Sulfur metabolism_Homo sapiens_hsa009201.19248952
60cAMP signaling pathway_Homo sapiens_hsa040241.16959500
61Glycerolipid metabolism_Homo sapiens_hsa005611.16674042
62Estrogen signaling pathway_Homo sapiens_hsa049151.14632187
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14196412
64Primary bile acid biosynthesis_Homo sapiens_hsa001201.13545743
65Selenocompound metabolism_Homo sapiens_hsa004501.12778605
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10260491
67ErbB signaling pathway_Homo sapiens_hsa040121.07896732
68Dorso-ventral axis formation_Homo sapiens_hsa043201.06792271
69Axon guidance_Homo sapiens_hsa043601.05545737
70cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04945369
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03432250
72Fatty acid biosynthesis_Homo sapiens_hsa000611.00804938
73PPAR signaling pathway_Homo sapiens_hsa033200.99205822
74Arginine biosynthesis_Homo sapiens_hsa002200.98898157
75Collecting duct acid secretion_Homo sapiens_hsa049660.94908533
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.93154340
77Vitamin B6 metabolism_Homo sapiens_hsa007500.93138381
78Melanogenesis_Homo sapiens_hsa049160.91106108
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.89138129
80Mineral absorption_Homo sapiens_hsa049780.87567440
81Propanoate metabolism_Homo sapiens_hsa006400.86038445
82Choline metabolism in cancer_Homo sapiens_hsa052310.85544890
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83018711
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82806736
85Arginine and proline metabolism_Homo sapiens_hsa003300.82081965
86Sphingolipid metabolism_Homo sapiens_hsa006000.79629720
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78552643
88MAPK signaling pathway_Homo sapiens_hsa040100.77751860
89Fanconi anemia pathway_Homo sapiens_hsa034600.77707362
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.77273331
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76783926
92Thyroid hormone synthesis_Homo sapiens_hsa049180.76664242
93Inositol phosphate metabolism_Homo sapiens_hsa005620.76478962
94Fatty acid degradation_Homo sapiens_hsa000710.76005579
95Endometrial cancer_Homo sapiens_hsa052130.75765399
96Pancreatic secretion_Homo sapiens_hsa049720.74817846
97mTOR signaling pathway_Homo sapiens_hsa041500.74786334
98Non-homologous end-joining_Homo sapiens_hsa034500.74268230
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.73730794
100Oocyte meiosis_Homo sapiens_hsa041140.72700145
101Arachidonic acid metabolism_Homo sapiens_hsa005900.68500527
102Dilated cardiomyopathy_Homo sapiens_hsa054140.68443276
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68298115
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65270159
105TGF-beta signaling pathway_Homo sapiens_hsa043500.64274060
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64208707
107VEGF signaling pathway_Homo sapiens_hsa043700.62837056
108Non-small cell lung cancer_Homo sapiens_hsa052230.62177097
109Ras signaling pathway_Homo sapiens_hsa040140.57365387
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57002497
111Chemokine signaling pathway_Homo sapiens_hsa040620.56874345
112Circadian rhythm_Homo sapiens_hsa047100.56724853
113Alcoholism_Homo sapiens_hsa050340.56028543
114Vibrio cholerae infection_Homo sapiens_hsa051100.55900526
115Wnt signaling pathway_Homo sapiens_hsa043100.55897622
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55839317
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55547725
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54434841
119Rap1 signaling pathway_Homo sapiens_hsa040150.53776431
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53121792
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52419588
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.51939316
123Tight junction_Homo sapiens_hsa045300.51114766
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51113980
125Renal cell carcinoma_Homo sapiens_hsa052110.50485629
126Colorectal cancer_Homo sapiens_hsa052100.49466335
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49043571
128Prolactin signaling pathway_Homo sapiens_hsa049170.48624064
129Glucagon signaling pathway_Homo sapiens_hsa049220.47468608
130African trypanosomiasis_Homo sapiens_hsa051430.46598060
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.45171101
132Insulin signaling pathway_Homo sapiens_hsa049100.44595210
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44528209
134Folate biosynthesis_Homo sapiens_hsa007900.44420881
135Bile secretion_Homo sapiens_hsa049760.44369211
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42683547
137Ovarian steroidogenesis_Homo sapiens_hsa049130.41458990
138Renin-angiotensin system_Homo sapiens_hsa046140.41330839
139Intestinal immune network for IgA production_Homo sapiens_hsa046720.41224800
140Basal transcription factors_Homo sapiens_hsa030220.40314379
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39479558
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38922520
143Endocytosis_Homo sapiens_hsa041440.38385694
144Hippo signaling pathway_Homo sapiens_hsa043900.37995097
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37595429
146Pancreatic cancer_Homo sapiens_hsa052120.37192786
147Lysine degradation_Homo sapiens_hsa003100.36178289
148Cardiac muscle contraction_Homo sapiens_hsa042600.35263933
149Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33806868
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33341939
151Phenylalanine metabolism_Homo sapiens_hsa003600.31756401
152Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30311809
153beta-Alanine metabolism_Homo sapiens_hsa004100.29827795
154Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29678211
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28105694
156Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25712875
157Peroxisome_Homo sapiens_hsa041460.25370012

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »