PHOSPHO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.72537627
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.59937886
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.36718145
4negative regulation of cell killing (GO:0031342)6.36718145
5polyketide metabolic process (GO:0030638)6.18476370
6doxorubicin metabolic process (GO:0044598)6.18476370
7daunorubicin metabolic process (GO:0044597)6.18476370
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.14430941
9positive regulation by organism of defense response of other organism involved in symbiotic interact6.14430941
10modulation by symbiont of host immune response (GO:0052553)6.14430941
11positive regulation by symbiont of host defense response (GO:0052509)6.14430941
12modulation by symbiont of host defense response (GO:0052031)6.14430941
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.14430941
14carnitine shuttle (GO:0006853)5.47947824
15neutrophil activation involved in immune response (GO:0002283)5.47576709
16negative regulation of potassium ion transmembrane transport (GO:1901380)5.43771603
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.41366444
18muscle filament sliding (GO:0030049)5.23278795
19actin-myosin filament sliding (GO:0033275)5.23278795
20positive regulation of gamma-delta T cell activation (GO:0046645)5.17043125
21antigen processing and presentation of endogenous antigen (GO:0019883)5.16399107
22cytidine metabolic process (GO:0046087)5.04678210
23cytidine catabolic process (GO:0006216)5.04678210
24cytidine deamination (GO:0009972)5.04678210
25regulation of skeletal muscle contraction (GO:0014819)5.01679576
26macrophage activation involved in immune response (GO:0002281)4.99588047
27detection of other organism (GO:0098543)4.95837423
28pyrimidine ribonucleoside catabolic process (GO:0046133)4.90012135
29regulation of B cell receptor signaling pathway (GO:0050855)4.83043277
30fatty acid transmembrane transport (GO:1902001)4.82198048
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.79889642
32detection of bacterium (GO:0016045)4.79542366
33regulation of response to osmotic stress (GO:0047484)4.78537393
34sarcomere organization (GO:0045214)4.78195667
35tricarboxylic acid cycle (GO:0006099)4.69790793
36oxygen transport (GO:0015671)4.69086715
37plasma membrane repair (GO:0001778)4.54041338
38carnitine transmembrane transport (GO:1902603)4.46010333
39response to interleukin-15 (GO:0070672)4.43675039
40neutrophil activation (GO:0042119)4.41822718
41detection of external biotic stimulus (GO:0098581)4.30093299
42response to peptidoglycan (GO:0032494)4.29404922
43negative regulation of lymphocyte mediated immunity (GO:0002707)4.28980102
44cellular extravasation (GO:0045123)4.28403796
45myofibril assembly (GO:0030239)4.25480313
46regulation of interferon-beta biosynthetic process (GO:0045357)4.22030455
47detection of molecule of bacterial origin (GO:0032490)4.21778195
48respiratory burst (GO:0045730)4.21332606
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.20231650
50regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.19441700
51cellular response to interleukin-15 (GO:0071350)4.18701304
52leukocyte aggregation (GO:0070486)4.18571793
53amino-acid betaine transport (GO:0015838)4.15905388
54carnitine transport (GO:0015879)4.15905388
55biotin metabolic process (GO:0006768)4.15525314
56actin-mediated cell contraction (GO:0070252)4.14991355
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.13473898
58regulation of sequestering of triglyceride (GO:0010889)4.13155880
59negative regulation of interleukin-12 production (GO:0032695)4.07579087
60response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.04630775
61response to host immune response (GO:0052572)4.04630775
62hormone catabolic process (GO:0042447)4.03284295
63granulocyte activation (GO:0036230)4.01259313
64leukocyte migration involved in inflammatory response (GO:0002523)3.91812328
65neutrophil mediated immunity (GO:0002446)3.91293331
66positive regulation of histone deacetylation (GO:0031065)3.90117362
67microglial cell activation (GO:0001774)3.89909515
68negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.84280864
69regulation of gamma-delta T cell activation (GO:0046643)3.82556493
70regulation of mast cell degranulation (GO:0043304)3.81956399
71gas transport (GO:0015669)3.81537989
72maintenance of protein location in nucleus (GO:0051457)3.79403344
73cardiac myofibril assembly (GO:0055003)3.77560848
74myeloid cell activation involved in immune response (GO:0002275)3.77461998
75regulation of acyl-CoA biosynthetic process (GO:0050812)3.76240915
76negative regulation of leukocyte mediated immunity (GO:0002704)3.75375052
77aminoglycoside antibiotic metabolic process (GO:0030647)3.75278021
78negative regulation of phagocytosis (GO:0050765)3.72281738
79response to host defenses (GO:0052200)3.69212435
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.69212435
81response to host (GO:0075136)3.69212435
82detection of biotic stimulus (GO:0009595)3.68744496
83sarcoplasmic reticulum calcium ion transport (GO:0070296)3.66445191
84porphyrin-containing compound biosynthetic process (GO:0006779)3.65885188
85skeletal muscle adaptation (GO:0043501)3.64907155
86positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.64623376
87macrophage activation (GO:0042116)3.64536626
88negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.61700175
89skeletal muscle contraction (GO:0003009)3.59801652
90regulation of T-helper 2 cell differentiation (GO:0045628)3.59543149
91negative regulation of cell size (GO:0045792)3.58377902
92striated muscle contraction (GO:0006941)3.57857957
93muscle organ morphogenesis (GO:0048644)3.56902792
94regulation of mast cell activation involved in immune response (GO:0033006)3.52583258
95immunoglobulin mediated immune response (GO:0016064)3.52399718
96regulation of myeloid leukocyte mediated immunity (GO:0002886)3.48297460
97negative regulation of T cell mediated immunity (GO:0002710)3.47090612
98leukocyte degranulation (GO:0043299)3.44737340
99NADH metabolic process (GO:0006734)3.44489873
100production of molecular mediator involved in inflammatory response (GO:0002532)3.44453372
101regulation of fatty acid oxidation (GO:0046320)3.44338074
102regulation of coenzyme metabolic process (GO:0051196)3.43110956
103regulation of cofactor metabolic process (GO:0051193)3.43110956
104regulation of gamma-delta T cell differentiation (GO:0045586)3.38450927
105coenzyme catabolic process (GO:0009109)3.36508207
106positive regulation of mast cell activation (GO:0033005)3.36238454
107positive regulation of protein deacetylation (GO:0090312)3.35655608
108glycolytic process (GO:0006096)3.33009967
109regulation of leukocyte degranulation (GO:0043300)3.32359623
110epoxygenase P450 pathway (GO:0019373)3.31941575
111quaternary ammonium group transport (GO:0015697)3.30995502
112negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.30677601
113cardiac muscle cell development (GO:0055013)3.29433358
114maternal placenta development (GO:0001893)3.24529219
115regulation of T cell tolerance induction (GO:0002664)3.24097456
116myeloid leukocyte mediated immunity (GO:0002444)3.23252002
117tetrapyrrole biosynthetic process (GO:0033014)3.22675780
118creatine metabolic process (GO:0006600)3.21888120
119vitamin A metabolic process (GO:0006776)3.21859708
120actin filament-based movement (GO:0030048)3.20678185
121B cell receptor signaling pathway (GO:0050853)3.19951255
122regulation of mast cell activation (GO:0033003)3.19600847
123cardiac muscle contraction (GO:0060048)3.18672212
124somite rostral/caudal axis specification (GO:0032525)3.17758508
125fatty acid beta-oxidation (GO:0006635)3.16007540
126negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.15995596
127lysine catabolic process (GO:0006554)3.15272984
128lysine metabolic process (GO:0006553)3.15272984
129protoporphyrinogen IX metabolic process (GO:0046501)3.15119559
130type I interferon signaling pathway (GO:0060337)3.13314511
131cellular response to type I interferon (GO:0071357)3.13314511
132germinal center formation (GO:0002467)3.12325841
133valine metabolic process (GO:0006573)3.11756883
134glycogen catabolic process (GO:0005980)3.11300419
135response to type I interferon (GO:0034340)3.11120020
136negative regulation of erythrocyte differentiation (GO:0045647)3.10825709
137negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.10542446
138glucan catabolic process (GO:0009251)3.09798803
139cellular response to osmotic stress (GO:0071470)3.09395748
140regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.05979152
141negative regulation of cell cycle G2/M phase transition (GO:1902750)3.05739748
142cardiac cell development (GO:0055006)3.04844256
143regulation of B cell differentiation (GO:0045577)3.04500128
144cellular modified amino acid catabolic process (GO:0042219)3.03968581
145regulation of tolerance induction (GO:0002643)3.03791341
146negative regulation of interleukin-6 production (GO:0032715)3.03591734
147tolerance induction (GO:0002507)3.02597754
148regulation of platelet aggregation (GO:0090330)3.02229160
149positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.01576357
150positive regulation of fatty acid beta-oxidation (GO:0032000)3.00800134
151actomyosin structure organization (GO:0031032)3.00259135
152positive regulation of T cell mediated cytotoxicity (GO:0001916)2.98214500
153antigen processing and presentation via MHC class Ib (GO:0002475)2.95826442
154negative regulation of cAMP-mediated signaling (GO:0043951)2.95793585
155regulation of T cell mediated cytotoxicity (GO:0001914)2.95410299
156retinoic acid receptor signaling pathway (GO:0048384)2.95006147
157regulation of regulated secretory pathway (GO:1903305)2.94939257
158quinone metabolic process (GO:1901661)2.94208078
159porphyrin-containing compound metabolic process (GO:0006778)2.93709986
160regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.93054969
161positive thymic T cell selection (GO:0045059)2.91013924
162defense response to protozoan (GO:0042832)2.90665068
1632-oxoglutarate metabolic process (GO:0006103)2.90506208
164pyruvate metabolic process (GO:0006090)2.90003813
165negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.89601191
166negative regulation of T-helper cell differentiation (GO:0045623)2.89601191
167intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.89397290
168dendritic cell migration (GO:0036336)2.88423323
169negative regulation of type 2 immune response (GO:0002829)2.88140226
170cellular polysaccharide catabolic process (GO:0044247)2.86581710
171negative regulation of telomerase activity (GO:0051974)2.86317470
172negative regulation of cytokine production involved in immune response (GO:0002719)2.86235445
173response to muramyl dipeptide (GO:0032495)2.85347734
174regulation of cilium movement (GO:0003352)2.84820187
175positive regulation of fatty acid oxidation (GO:0046321)2.84656610
176regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.83560497
177regulation of natural killer cell mediated immunity (GO:0002715)2.83560497
178heme biosynthetic process (GO:0006783)2.83369487
179myeloid leukocyte activation (GO:0002274)2.82937577
180dendritic cell chemotaxis (GO:0002407)2.82715757
181long-chain fatty acid transport (GO:0015909)2.82154202
182regulation of glucose import in response to insulin stimulus (GO:2001273)2.81828862
183positive regulation of granulocyte differentiation (GO:0030854)2.81544374
184regulation of p38MAPK cascade (GO:1900744)2.80808027
185lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79232261
186positive regulation of B cell differentiation (GO:0045579)2.79142328
187receptor recycling (GO:0001881)2.78905210
188negative regulation of alpha-beta T cell activation (GO:0046636)2.78815969
189positive regulation of mast cell activation involved in immune response (GO:0033008)2.77642520
190positive regulation of mast cell degranulation (GO:0043306)2.77642520
191regulation of mammary gland epithelial cell proliferation (GO:0033599)2.77288661
192muscle contraction (GO:0006936)2.77062910
193regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.76547287
194negative regulation of epidermis development (GO:0045683)2.74822636
195aspartate family amino acid catabolic process (GO:0009068)2.74303581
196mitochondrion localization (GO:0051646)2.72733343
197heterochromatin organization (GO:0070828)2.72430222
198cardiac muscle tissue morphogenesis (GO:0055008)2.71599092
199polysaccharide catabolic process (GO:0000272)2.69069433
200branched-chain amino acid catabolic process (GO:0009083)2.68842051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.07519777
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.57783575
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.12823801
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.53191995
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.45160189
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.45160189
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.45160189
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.27830594
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.25372558
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.89884884
11VDR_21846776_ChIP-Seq_THP-1_Human2.79587442
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74103290
13SPI1_23127762_ChIP-Seq_K562_Human2.67059249
14RUNX_20019798_ChIP-Seq_JUKART_Human2.59524116
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.58782583
16VDR_24763502_ChIP-Seq_THP-1_Human2.58066738
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.54075976
18* SPI1_23547873_ChIP-Seq_NB4_Human2.46809790
19MAF_26560356_Chip-Seq_TH1_Human2.45645476
20* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45588299
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40850914
22UTX_26944678_Chip-Seq_JUKART_Human2.31632307
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.30470522
24* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28228614
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.27483978
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.24687506
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23066353
28ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.21930296
29NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.16365844
30MYB_26560356_Chip-Seq_TH2_Human2.16353118
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.12486706
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.08086361
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07416019
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.07186986
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.00894170
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00450942
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99066678
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.98708516
39ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.97286636
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.97108909
41MYB_26560356_Chip-Seq_TH1_Human1.96483580
42* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95269267
43MAF_26560356_Chip-Seq_TH2_Human1.94856319
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91084472
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90500336
46* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89577954
47NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.88712737
48LXR_22292898_ChIP-Seq_THP-1_Human1.86270048
49* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.85125742
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.84871253
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82969624
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78426968
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.70614904
54TCF7_22412390_ChIP-Seq_EML_Mouse1.67457054
55* RXR_22158963_ChIP-Seq_LIVER_Mouse1.66164455
56GATA1_19941826_ChIP-Seq_K562_Human1.65180194
57SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.62409290
58* GATA3_27048872_Chip-Seq_THYMUS_Human1.61157349
59RACK7_27058665_Chip-Seq_MCF-7_Human1.61067981
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60769875
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57974898
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.56265919
63* KDM2B_26808549_Chip-Seq_K562_Human1.51464080
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51019126
65GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50519251
66LXR_22158963_ChIP-Seq_LIVER_Mouse1.50007379
67* KDM2B_26808549_Chip-Seq_DND41_Human1.49979638
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.49816574
69ZNF263_19887448_ChIP-Seq_K562_Human1.49631419
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.49053902
71TBX20_22328084_ChIP-Seq_HEART_Mouse1.49053902
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48836781
73P68_20966046_ChIP-Seq_HELA_Human1.47391541
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46580508
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45498018
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45160198
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44673535
78VDR_24787735_ChIP-Seq_THP-1_Human1.43882229
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.43193531
80* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42669979
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41737978
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39911444
83* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39074679
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39065066
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38880896
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.38536762
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.38259111
88NCOR1_26117541_ChIP-Seq_K562_Human1.38010867
89BCOR_27268052_Chip-Seq_Bcells_Human1.37222055
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36798403
91FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35771672
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34681283
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34563609
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34196623
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33996229
96KDM2B_26808549_Chip-Seq_JURKAT_Human1.33433282
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.31946558
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31348700
99SMC4_20622854_ChIP-Seq_HELA_Human1.30810834
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30110641
101SCL_19346495_ChIP-Seq_HPC-7_Human1.29654215
102CTCF_21964334_Chip-Seq_Bcells_Human1.29601003
103TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29502725
104TP53_22127205_ChIP-Seq_IMR90_Human1.29482369
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29447561
106EGR1_19374776_ChIP-ChIP_THP-1_Human1.29226647
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.27244988
108* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25719332
109SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25661874
110NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.25599652
111* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24629055
112BCL6_27268052_Chip-Seq_Bcells_Human1.23316543
113ESR1_20079471_ChIP-ChIP_T-47D_Human1.23140812
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22543279
115TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21852753
116CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21525830
117SA1_27219007_Chip-Seq_ERYTHROID_Human1.21336050
118TP63_22573176_ChIP-Seq_HFKS_Human1.20730813
119* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19791484
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18500589
121* ATF3_27146783_Chip-Seq_COLON_Human1.18249765
122TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.17843268
123YY1_22570637_ChIP-Seq_MALME-3M_Human1.17257564
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16435873
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16026676
126MYC_22102868_ChIP-Seq_BL_Human1.15895133
127NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15837060
128PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15218882
129NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14548453
130* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14179270
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13463111
132ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12185052
133* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12155730
134CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11939746
135POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11527406
136GATA2_19941826_ChIP-Seq_K562_Human1.11307482
137P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10886591
138CREB1_26743006_Chip-Seq_LNCaP_Human1.10808042
139GATA1_22025678_ChIP-Seq_K562_Human1.10726966
140GATA3_26560356_Chip-Seq_TH2_Human1.10591627
141* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09409923
142PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.08457105
143KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07879600
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07813223
145* PU_27001747_Chip-Seq_BMDM_Mouse1.07742754
146KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06467486
147IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06125636
148SPI1_20517297_ChIP-Seq_HL60_Human1.04166238
149FOXO3_23340844_ChIP-Seq_DLD1_Human1.04100444
150MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03725844
151SA1_27219007_Chip-Seq_Bcells_Human1.03633282
152* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03605725
153PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01937825
154GATA2_21666600_ChIP-Seq_HMVEC_Human1.01494488
155RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01317983
156NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00895367
157* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00133348
158STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99736421
159CTCF_27219007_Chip-Seq_Bcells_Human0.98788870
160CSB_26484114_Chip-Seq_FIBROBLAST_Human0.97715918
161SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97425928
162FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97359106
163ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97180849
164CDX2_20551321_ChIP-Seq_CACO-2_Human0.97107819
165GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96029041
166DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94964019
167PHF8_20622854_ChIP-Seq_HELA_Human0.94404862
168E2F1_20622854_ChIP-Seq_HELA_Human0.94035814
169E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92875984
170RUNX1_27514584_Chip-Seq_MCF-7_Human0.91294316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.77772900
2MP0003724_increased_susceptibility_to4.68637911
3MP0003646_muscle_fatigue4.63849072
4MP0003436_decreased_susceptibility_to4.30829953
5MP0000749_muscle_degeneration4.22371371
6MP0003303_peritoneal_inflammation3.93877193
7MP0000751_myopathy3.57749183
8MP0001835_abnormal_antigen_presentation3.16940658
9MP0002419_abnormal_innate_immunity3.06405947
10MP0003705_abnormal_hypodermis_morpholog3.04748442
11MP0002332_abnormal_exercise_endurance3.04278703
12MP0004185_abnormal_adipocyte_glucose2.98109462
13MP0004145_abnormal_muscle_electrophysio2.85206110
14MP0005025_abnormal_response_to2.77051020
15MP0004087_abnormal_muscle_fiber2.73351041
16MP0000685_abnormal_immune_system2.71157984
17MP0004084_abnormal_cardiac_muscle2.68350922
18MP0005387_immune_system_phenotype2.64960767
19MP0001790_abnormal_immune_system2.64960767
20MP0001800_abnormal_humoral_immune2.64627770
21MP0002269_muscular_atrophy2.63225653
22MP0005671_abnormal_response_to2.61962998
23MP0004036_abnormal_muscle_relaxation2.60970955
24MP0002132_abnormal_respiratory_system2.59975281
25MP0000750_abnormal_muscle_regeneration2.59647548
26MP0003656_abnormal_erythrocyte_physiolo2.57673124
27MP0005666_abnormal_adipose_tissue2.56231797
28MP0005330_cardiomyopathy2.54976827
29MP0005000_abnormal_immune_tolerance2.54658290
30MP0009785_altered_susceptibility_to2.53141269
31MP0000759_abnormal_skeletal_muscle2.48053564
32MP0004130_abnormal_muscle_cell2.48005403
33MP0004215_abnormal_myocardial_fiber2.43810258
34MP0008260_abnormal_autophagy2.43388939
35MP0002420_abnormal_adaptive_immunity2.42848986
36MP0001819_abnormal_immune_cell2.39986697
37MP0002723_abnormal_immune_serum2.39892728
38MP0002106_abnormal_muscle_physiology2.39477056
39MP0003300_gastrointestinal_ulcer2.38538730
40MP0006082_CNS_inflammation2.35680080
41MP0002254_reproductive_system_inflammat2.29947806
42MP0002452_abnormal_antigen_presenting2.25443194
43MP0005377_hearing/vestibular/ear_phenot2.14854871
44MP0003878_abnormal_ear_physiology2.14854871
45MP0005670_abnormal_white_adipose2.12902853
46MP0005464_abnormal_platelet_physiology2.12112883
47MP0005620_abnormal_muscle_contractility2.11568840
48MP0002405_respiratory_system_inflammati2.10655558
49MP0003011_delayed_dark_adaptation2.08044028
50MP0000747_muscle_weakness2.07812166
51MP0006036_abnormal_mitochondrial_physio2.06339206
52MP0001533_abnormal_skeleton_physiology2.06334883
53MP0003763_abnormal_thymus_physiology2.00536948
54MP0005369_muscle_phenotype1.98820675
55MP0002398_abnormal_bone_marrow1.98202567
56MP0006035_abnormal_mitochondrial_morpho1.93854539
57MP0005451_abnormal_body_composition1.91097378
58MP0003137_abnormal_impulse_conducting1.89257909
59MP0009278_abnormal_bone_marrow1.88465980
60MP0002148_abnormal_hypersensitivity_rea1.86098812
61MP0004858_abnormal_nervous_system1.82352685
62MP0000716_abnormal_immune_system1.80907915
63MP0004264_abnormal_extraembryonic_tissu1.78573556
64MP0010630_abnormal_cardiac_muscle1.78083378
65MP0008961_abnormal_basal_metabolism1.77963327
66MP0003172_abnormal_lysosome_physiology1.76865179
67MP0008775_abnormal_heart_ventricle1.74643131
68MP0002972_abnormal_cardiac_muscle1.72885473
69MP0003866_abnormal_defecation1.71386938
70MP0005397_hematopoietic_system_phenotyp1.70868566
71MP0001545_abnormal_hematopoietic_system1.70868566
72MP0002396_abnormal_hematopoietic_system1.65910999
73MP0005375_adipose_tissue_phenotype1.63066519
74MP0002722_abnormal_immune_system1.62747474
75MP0002277_abnormal_respiratory_mucosa1.62094474
76MP0005310_abnormal_salivary_gland1.61664219
77MP0003183_abnormal_peptide_metabolism1.59996040
78MP0010155_abnormal_intestine_physiology1.59972336
79MP0000689_abnormal_spleen_morphology1.57650685
80MP0001845_abnormal_inflammatory_respons1.54605987
81MP0009333_abnormal_splenocyte_physiolog1.53827938
82MP0002971_abnormal_brown_adipose1.52339702
83MP0004947_skin_inflammation1.51464274
84MP0002429_abnormal_blood_cell1.49999298
85MP0000703_abnormal_thymus_morphology1.49293906
86MP0005266_abnormal_metabolism1.48277406
87MP0009764_decreased_sensitivity_to1.46872434
88MP0004381_abnormal_hair_follicle1.46262343
89MP0001544_abnormal_cardiovascular_syste1.40252649
90MP0005385_cardiovascular_system_phenoty1.40252649
91MP0000343_altered_response_to1.36888290
92MP0008469_abnormal_protein_level1.35274604
93MP0003221_abnormal_cardiomyocyte_apopto1.35197022
94MP0006138_congestive_heart_failure1.32506436
95MP0003828_pulmonary_edema1.31151108
96MP0004484_altered_response_of1.30220024
97MP0000465_gastrointestinal_hemorrhage1.29717084
98MP0009115_abnormal_fat_cell1.26267951
99MP0002127_abnormal_cardiovascular_syste1.23336808
100MP0002970_abnormal_white_adipose1.23049125
101MP0004883_abnormal_blood_vessel1.18672175
102MP0001851_eye_inflammation1.18095333
103MP0004233_abnormal_muscle_weight1.17857263
104MP0002108_abnormal_muscle_morphology1.16969352
105MP0004043_abnormal_pH_regulation1.14939630
106MP0001849_ear_inflammation1.09832825
107MP0004085_abnormal_heartbeat1.09264920
108MP0005319_abnormal_enzyme/_coenzyme1.08198937
109MP0004147_increased_porphyrin_level1.07954023
110MP0003075_altered_response_to1.05516362
111MP0005257_abnormal_intraocular_pressure1.04954390
112MP0010352_gastrointestinal_tract_polyps1.04904339
113MP0000858_altered_metastatic_potential1.04588808
114MP0000733_abnormal_muscle_development1.03501612
115MP0002998_abnormal_bone_remodeling1.01951093
116MP0003806_abnormal_nucleotide_metabolis1.01795213
117MP0005410_abnormal_fertilization1.00942570
118MP0005164_abnormal_response_to0.98737385
119MP0001986_abnormal_taste_sensitivity0.98065042
120MP0000490_abnormal_crypts_of0.97177655
121MP0000266_abnormal_heart_morphology0.94998193
122MP0001873_stomach_inflammation0.91806218
123MP0000015_abnormal_ear_pigmentation0.91117921
124MP0003045_fibrosis0.88407726
125MP0002653_abnormal_ependyma_morphology0.87569870
126MP0008004_abnormal_stomach_pH0.85527166
127MP0005166_decreased_susceptibility_to0.85156351
128MP0003690_abnormal_glial_cell0.83883685
129MP0001663_abnormal_digestive_system0.83464771
130MP0010329_abnormal_lipoprotein_level0.82808816
131MP0000609_abnormal_liver_physiology0.81424513
132MP0003950_abnormal_plasma_membrane0.81121751
133MP0004808_abnormal_hematopoietic_stem0.80579602
134MP0005083_abnormal_biliary_tract0.80283066
135MP0003566_abnormal_cell_adhesion0.79532583
136MP0003191_abnormal_cellular_cholesterol0.79154408
137MP0002088_abnormal_embryonic_growth/wei0.79061628
138MP0003984_embryonic_growth_retardation0.78556845
139MP0008770_decreased_survivor_rate0.78477607
140MP0005390_skeleton_phenotype0.76969262
141MP0009840_abnormal_foam_cell0.76301384
142MP0005167_abnormal_blood-brain_barrier0.75578218
143MP0005499_abnormal_olfactory_system0.74212077
144MP0005394_taste/olfaction_phenotype0.74212077
145MP0000003_abnormal_adipose_tissue0.74057869
146MP0009763_increased_sensitivity_to0.73827503
147MP0005248_abnormal_Harderian_gland0.73286519
148MP0005275_abnormal_skin_tensile0.72879898
149MP0002118_abnormal_lipid_homeostasis0.71617144
150MP0008874_decreased_physiological_sensi0.71279942
151MP0009765_abnormal_xenobiotic_induced0.69632238
152MP0005452_abnormal_adipose_tissue0.69601602
153MP0003279_aneurysm0.69095942
154MP0002877_abnormal_melanocyte_morpholog0.68908718
155MP0005380_embryogenesis_phenotype0.68785858
156MP0001672_abnormal_embryogenesis/_devel0.68785858
157MP0002138_abnormal_hepatobiliary_system0.68773940
158MP0005360_urolithiasis0.68390186
159MP0005448_abnormal_energy_balance0.66819048
160MP0000762_abnormal_tongue_morphology0.66777337
161MP0005334_abnormal_fat_pad0.65755045
162MP0002078_abnormal_glucose_homeostasis0.64820757
163MP0005023_abnormal_wound_healing0.64356737
164MP0002925_abnormal_cardiovascular_devel0.63467026
165MP0005075_abnormal_melanosome_morpholog0.62682237
166MP0003448_altered_tumor_morphology0.61645424
167MP0002796_impaired_skin_barrier0.61505718
168MP0000678_abnormal_parathyroid_gland0.60935139
169MP0002166_altered_tumor_susceptibility0.60139475
170MP0005376_homeostasis/metabolism_phenot0.59915355
171MP0005623_abnormal_meninges_morphology0.59706368
172MP0003795_abnormal_bone_structure0.58692487
173MP0002909_abnormal_adrenal_gland0.58618307
174MP0003890_abnormal_embryonic-extraembry0.58376907
175MP0002928_abnormal_bile_duct0.58260243
176MP0000249_abnormal_blood_vessel0.54862996
177MP0002933_joint_inflammation0.54307704
178MP0004510_myositis0.54101907
179MP0005085_abnormal_gallbladder_physiolo0.53971986
180MP0005584_abnormal_enzyme/coenzyme_acti0.53883178
181MP0000604_amyloidosis0.49531859
182MP0000470_abnormal_stomach_morphology0.48518894
183MP0005058_abnormal_lysosome_morphology0.46942369

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.55066045
2Exercise-induced muscle cramps (HP:0003710)6.45524361
3Exercise-induced myalgia (HP:0003738)6.28861965
4Difficulty running (HP:0009046)5.76875674
5Recurrent abscess formation (HP:0002722)5.74633688
6Myositis (HP:0100614)5.63638580
7Recurrent bacterial skin infections (HP:0005406)5.55219181
8Increased connective tissue (HP:0009025)5.46618305
9Myoglobinuria (HP:0002913)5.37478920
10Orchitis (HP:0100796)5.31054007
11Abnormality of macrophages (HP:0004311)5.23805494
12Stomatitis (HP:0010280)4.83644870
13Recurrent gram-negative bacterial infections (HP:0005420)4.81528176
14Retrobulbar optic neuritis (HP:0100654)4.80473283
15Optic neuritis (HP:0100653)4.80473283
16Microcytic anemia (HP:0001935)4.62180758
17Gastrointestinal infarctions (HP:0005244)4.54846555
18Hypochromic microcytic anemia (HP:0004840)4.46102884
19Hyporeflexia of lower limbs (HP:0002600)4.38122696
20Muscle fiber splitting (HP:0003555)4.34838352
21Ventricular tachycardia (HP:0004756)4.33953364
22Muscle fiber inclusion bodies (HP:0100299)4.32938264
23Elevated erythrocyte sedimentation rate (HP:0003565)4.31587523
24Muscle hypertrophy of the lower extremities (HP:0008968)4.28705345
25Chronic obstructive pulmonary disease (HP:0006510)4.21395666
26Obstructive lung disease (HP:0006536)4.21395666
27Sudden death (HP:0001699)4.20078527
28Calf muscle hypertrophy (HP:0008981)4.18487720
29Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.14256642
30Rhabdomyolysis (HP:0003201)4.06306591
31Type 1 muscle fiber predominance (HP:0003803)3.99696664
32EMG: myopathic abnormalities (HP:0003458)3.84605116
33Abnormal delayed hypersensitivity skin test (HP:0002963)3.81074926
34Spontaneous hematomas (HP:0007420)3.76410473
35Increased IgE level (HP:0003212)3.76041425
36Muscle stiffness (HP:0003552)3.75634805
37Prolonged bleeding time (HP:0003010)3.75576054
38Recurrent fungal infections (HP:0002841)3.74533715
39Urticaria (HP:0001025)3.73896098
40Meningitis (HP:0001287)3.72624666
41Mediastinal lymphadenopathy (HP:0100721)3.66610296
42Multiple enchondromatosis (HP:0005701)3.66099343
43Recurrent skin infections (HP:0001581)3.63259637
44Gingivitis (HP:0000230)3.61709657
45Encephalitis (HP:0002383)3.53903264
46Testicular atrophy (HP:0000029)3.53859493
47Increased variability in muscle fiber diameter (HP:0003557)3.53039940
48Nemaline bodies (HP:0003798)3.50419567
49Keratoconjunctivitis sicca (HP:0001097)3.48339574
50Abnormal hemoglobin (HP:0011902)3.37577541
51Difficulty climbing stairs (HP:0003551)3.36442945
52Abnormality of skeletal muscle fiber size (HP:0012084)3.36036907
53Bilateral microphthalmos (HP:0007633)3.31329641
54Mildly elevated creatine phosphokinase (HP:0008180)3.29765801
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.29104250
56Abnormality of the calf musculature (HP:0001430)3.27862020
57Vasculitis (HP:0002633)3.25914691
58Myotonia (HP:0002486)3.22813662
59Keratoconjunctivitis (HP:0001096)3.22080792
60Episodic fever (HP:0001954)3.21386256
61Cellulitis (HP:0100658)3.20256514
62Abnormality of the lower motor neuron (HP:0002366)3.18567668
63Chest pain (HP:0100749)3.14943096
64Myopathic facies (HP:0002058)3.14458668
65Reticulocytosis (HP:0001923)3.11714087
66Toxemia of pregnancy (HP:0100603)3.09600297
67Peritonitis (HP:0002586)3.08063131
68EMG: neuropathic changes (HP:0003445)3.05834962
69Recurrent cutaneous fungal infections (HP:0011370)3.05589699
70Chronic mucocutaneous candidiasis (HP:0002728)3.05589699
71Cholelithiasis (HP:0001081)3.04082361
72Gingival bleeding (HP:0000225)3.00526489
73Subaortic stenosis (HP:0001682)2.99814782
74Abnormality of the left ventricular outflow tract (HP:0011103)2.99814782
75Ragged-red muscle fibers (HP:0003200)2.96864271
76Round ear (HP:0100830)2.96314205
77Inflammation of the large intestine (HP:0002037)2.93573678
78Asymmetric septal hypertrophy (HP:0001670)2.91797789
79Distal arthrogryposis (HP:0005684)2.88747526
80Hyperinsulinemic hypoglycemia (HP:0000825)2.86295999
81Gastrointestinal inflammation (HP:0004386)2.84710142
82Pustule (HP:0200039)2.84472445
83Ulnar deviation of the wrist (HP:0003049)2.79112184
84Anorexia (HP:0002039)2.78685793
85Epistaxis (HP:0000421)2.73581708
86Petechiae (HP:0000967)2.71239396
87Paralysis (HP:0003470)2.71114123
88Leukocytosis (HP:0001974)2.70544176
89Progressive muscle weakness (HP:0003323)2.66498837
90Hepatoblastoma (HP:0002884)2.65001958
91Achilles tendon contracture (HP:0001771)2.64255837
92Slow saccadic eye movements (HP:0000514)2.63876788
93Abnormal gallbladder morphology (HP:0012437)2.63061092
94Pulmonary infiltrates (HP:0002113)2.61506971
95Right ventricular cardiomyopathy (HP:0011663)2.61119602
96Atrial fibrillation (HP:0005110)2.60838260
97Severe visual impairment (HP:0001141)2.58243885
98Osteomyelitis (HP:0002754)2.57670853
99Hemoptysis (HP:0002105)2.56775896
100Hyperglycinuria (HP:0003108)2.55372729
101T lymphocytopenia (HP:0005403)2.50420191
102Arterial thrombosis (HP:0004420)2.48862849
103Poikilocytosis (HP:0004447)2.48077631
104Abnormality of the Achilles tendon (HP:0005109)2.46358938
105Lipoatrophy (HP:0100578)2.45693551
106Primary atrial arrhythmia (HP:0001692)2.44205875
107Increased IgM level (HP:0003496)2.39759248
108Bundle branch block (HP:0011710)2.39501334
109Abnormality of T cell number (HP:0011839)2.39489674
110Pulmonary embolism (HP:0002204)2.39442769
111Abnormal cartilage morphology (HP:0002763)2.39364265
112Nasal polyposis (HP:0100582)2.37882469
113Abnormality of T cells (HP:0002843)2.37074048
114Distal lower limb muscle weakness (HP:0009053)2.34200359
115Supraventricular tachycardia (HP:0004755)2.33367482
116Dilated cardiomyopathy (HP:0001644)2.30152301
117Areflexia of lower limbs (HP:0002522)2.28989278
118Supraventricular arrhythmia (HP:0005115)2.28160620
119Neck muscle weakness (HP:0000467)2.24723955
120Abnormality of T cell physiology (HP:0011840)2.19877478
121Amyloidosis (HP:0011034)2.19217670
122Granulocytopenia (HP:0001913)2.19169096
123Rib fusion (HP:0000902)2.18821281
124Panhypogammaglobulinemia (HP:0003139)2.18782886
125Ventricular arrhythmia (HP:0004308)2.18778306
126Abnormality of iron homeostasis (HP:0011031)2.18550785
127Lymphopenia (HP:0001888)2.18517924
128Abnormality of the pericardium (HP:0001697)2.18325146
129Ketoacidosis (HP:0001993)2.16224046
130Glomerulopathy (HP:0100820)2.15387731
131Sepsis (HP:0100806)2.15079384
132Recurrent viral infections (HP:0004429)2.14221404
133Abnormal atrioventricular conduction (HP:0005150)2.09887291
134Abnormality of the peritoneum (HP:0002585)2.09057042
135Abnormality of the pubic bones (HP:0003172)2.08353444
136Abnormal platelet volume (HP:0011876)2.08235764
137Acne (HP:0001061)2.08158265
138Hypoplastic ischia (HP:0003175)2.07985373
139Hamartoma of the eye (HP:0010568)2.07213283
140Increased serum ferritin (HP:0003281)2.06622626
141Purpura (HP:0000979)2.05852901
142Abnormality of the salivary glands (HP:0010286)2.05114705
143Metaphyseal cupping (HP:0003021)2.04053855
144Hypochromic anemia (HP:0001931)2.03346465
145Abnormality of the pleura (HP:0002103)2.03144117
146Abnormality of cells of the lymphoid lineage (HP:0012140)2.02137176
147Hypergammaglobulinemia (HP:0010702)2.00785132
148Ependymoma (HP:0002888)2.00578099
149Recurrent pneumonia (HP:0006532)1.99595621
150Heart block (HP:0012722)1.99293284
151Facial diplegia (HP:0001349)1.98778192
152Skin nodule (HP:0200036)1.98402795
153IgM deficiency (HP:0002850)1.98077452
154Distal lower limb amyotrophy (HP:0008944)1.97855153
155Abnormality of the heme biosynthetic pathway (HP:0010472)1.96062699
156Generalized muscle weakness (HP:0003324)1.93261690
157Abnormality of the nasal mucosa (HP:0000433)1.93118791
158Palpitations (HP:0001962)1.92357417
159Atrioventricular block (HP:0001678)1.90865260
160Resting tremor (HP:0002322)1.89792880
161Hepatosplenomegaly (HP:0001433)1.89760253
162Gangrene (HP:0100758)1.89394253
163Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89105831
164Dicarboxylic aciduria (HP:0003215)1.89105831
165Vertigo (HP:0002321)1.88979424
166Abnormality of transition element cation homeostasis (HP:0011030)1.86433283
167Colitis (HP:0002583)1.85852255
168Malnutrition (HP:0004395)1.85716445
169Skin ulcer (HP:0200042)1.84989065
170Polycythemia (HP:0001901)1.81551396
171Recurrent lower respiratory tract infections (HP:0002783)1.81141190
172Acute hepatic failure (HP:0006554)1.80981784
173Abnormality of glycine metabolism (HP:0010895)1.80352653
174Abnormality of serine family amino acid metabolism (HP:0010894)1.80352653
175Distal upper limb amyotrophy (HP:0007149)1.80324422
176Upper limb amyotrophy (HP:0009129)1.80324422
177Abnormality of the fingertips (HP:0001211)1.79776791
178Abnormality of the ischium (HP:0003174)1.78180155
179Ulnar bowing (HP:0003031)1.77724555
180Abnormality of the endocardium (HP:0004306)1.77540550
181Hypoalphalipoproteinemia (HP:0003233)1.76561092
182Ketosis (HP:0001946)1.76341740
183Premature loss of primary teeth (HP:0006323)1.75369800
184Splenomegaly (HP:0001744)1.74969999
185Keratitis (HP:0000491)1.74197427
186Difficulty walking (HP:0002355)1.73412017
187Cholecystitis (HP:0001082)1.72662433
188Abnormal gallbladder physiology (HP:0012438)1.72662433
189Diaphragmatic weakness (HP:0009113)1.72592857
190Frequent falls (HP:0002359)1.71887643
191Gout (HP:0001997)1.69499200
192Generalized amyotrophy (HP:0003700)1.69338377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.98489418
2RIPK44.54491714
3ERN13.97597293
4TTN3.71384786
5MAP4K13.52399254
6GRK53.22430008
7IRAK43.20449437
8TRIB33.08789742
9OBSCN2.86765441
10PDK42.85551469
11PDK32.85551469
12TNK22.82649892
13PHKG12.65026910
14PHKG22.65026910
15BLK2.63493058
16GRK62.54472813
17FES2.29013400
18TYK22.24617407
19TGFBR22.23560927
20PRPF4B1.99028899
21ZAP701.84455426
22BCKDK1.81268107
23HCK1.79066752
24ICK1.78676793
25PDK21.75585858
26TYRO31.72761739
27GRK71.63252682
28MAP3K11.60865776
29FGR1.60421815
30BTK1.59925849
31MAP3K101.52708097
32MAP3K71.52119067
33SYK1.50272265
34JAK31.49824516
35WNK11.46849246
36PKN21.43086605
37MAP2K31.42850821
38TXK1.40758641
39STK101.40146789
40CSF1R1.39608588
41RIPK11.38424832
42MAPK71.38086876
43SIK31.35441769
44GRK11.35146168
45MAP2K41.34618557
46NEK11.33399922
47PRKG21.33038003
48MAPK121.32499541
49PINK11.32083064
50IKBKE1.30010198
51LMTK21.29443138
52DMPK1.26924653
53LYN1.20984939
54MARK31.18967934
55TAOK11.18030854
56SIK21.16324602
57MOS1.13293608
58MATK1.10290872
59YES11.09456380
60TBK11.09337042
61TAOK31.08879115
62CAMK41.08861467
63MAPKAPK31.07273675
64PRKAA11.06280061
65SIK11.03739309
66MAP2K61.03473195
67TTK1.02905211
68NME11.00880253
69CDK190.99707238
70LCK0.98652914
71ADRBK20.93848462
72TESK20.93328045
73BMX0.91632872
74SMG10.91259012
75PRKAA20.91242700
76PRKD30.90467889
77DDR20.83496963
78MARK20.83444239
79JAK10.81281378
80MAP3K20.80157742
81STK110.80011872
82AKT20.79113965
83SGK30.78712344
84MAP3K130.78012870
85MAP3K30.77997443
86PAK40.77793114
87PDGFRA0.77180508
88STK380.76743526
89DYRK1B0.74275410
90ITK0.73176143
91NTRK10.71190389
92MAP3K140.70109624
93IRAK20.68431051
94IKBKB0.68364496
95PIK3CG0.68195050
96MTOR0.67429579
97IRAK10.66744963
98PIM10.66081767
99LATS20.64776581
100KIT0.63748484
101MAP3K110.61694276
102FYN0.61399139
103MAPK110.60618396
104CAMK1D0.59842999
105RPS6KC10.59638455
106RPS6KL10.59638455
107DYRK30.57849355
108FGFR30.56990950
109PDK10.56101321
110SGK20.56007918
111CSK0.55465845
112LRRK20.53729556
113TRPM70.52089376
114RPS6KA60.51463522
115MAP3K80.51354989
116STK40.50725948
117PRKCQ0.49736814
118EPHB10.48686196
119TEC0.48670860
120ADRBK10.48354102
121PRKD10.47758842
122PTK20.46375158
123PDPK10.46089311
124ALK0.45411615
125MAPKAPK20.44794081
126PRKACG0.44471002
127DAPK20.44200092
128PRKCZ0.43493910
129HIPK20.43099573
130KSR10.42806209
131PRKD20.41111986
132RAF10.40053178
133PAK30.38897130
134TESK10.38851708
135RPS6KA20.38499516
136PAK60.37792071
137MYLK0.36235745
138EEF2K0.36047474
139RET0.35792723
140PIK3CA0.35218152
141BMPR20.35125310
142RPS6KA10.35123334
143TAOK20.33207195
144SGK2230.32913259
145SGK4940.32913259
146MAP3K50.31324549
147PTK2B0.30250011
148MAP3K60.29745895
149PRKACB0.29510465
150STK240.29143065
151PTK60.29078372
152CAMK1G0.28282146
153CDK70.27669976
154MUSK0.27481010
155PRKCH0.27246028
156RPS6KA30.26407903
157JAK20.26162070
158KSR20.24642042
159GSK3A0.24215090
160MAPK40.23147472
161TIE10.21814115
162LATS10.21537700

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.50698696
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.53586761
3Vitamin B6 metabolism_Homo sapiens_hsa007503.18764559
4Osteoclast differentiation_Homo sapiens_hsa043803.02785978
5Propanoate metabolism_Homo sapiens_hsa006402.77823398
6Fatty acid degradation_Homo sapiens_hsa000712.71248472
7Leishmaniasis_Homo sapiens_hsa051402.69745328
8Fructose and mannose metabolism_Homo sapiens_hsa000512.61313163
9Malaria_Homo sapiens_hsa051442.49368317
10Carbon metabolism_Homo sapiens_hsa012002.48702472
11Staphylococcus aureus infection_Homo sapiens_hsa051502.45412120
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.43946919
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41134890
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.29566959
15B cell receptor signaling pathway_Homo sapiens_hsa046622.24590609
16Fatty acid metabolism_Homo sapiens_hsa012122.18229902
17Galactose metabolism_Homo sapiens_hsa000522.17181568
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.15234918
19Graft-versus-host disease_Homo sapiens_hsa053322.10735083
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07859387
21PPAR signaling pathway_Homo sapiens_hsa033202.07792250
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.05292740
23Tuberculosis_Homo sapiens_hsa051522.04619185
24Cardiac muscle contraction_Homo sapiens_hsa042602.02890042
25Dilated cardiomyopathy_Homo sapiens_hsa054141.98522978
26Allograft rejection_Homo sapiens_hsa053301.98394756
27Primary immunodeficiency_Homo sapiens_hsa053401.91195245
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90379782
29Autoimmune thyroid disease_Homo sapiens_hsa053201.87327110
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86088449
31African trypanosomiasis_Homo sapiens_hsa051431.81578306
32Chemokine signaling pathway_Homo sapiens_hsa040621.79669500
33Starch and sucrose metabolism_Homo sapiens_hsa005001.74145674
34Measles_Homo sapiens_hsa051621.73665884
35Pyruvate metabolism_Homo sapiens_hsa006201.70443865
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.64185597
37T cell receptor signaling pathway_Homo sapiens_hsa046601.63329554
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63053893
39Fatty acid biosynthesis_Homo sapiens_hsa000611.60859519
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.56459192
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55473808
42Hematopoietic cell lineage_Homo sapiens_hsa046401.51612936
43Toxoplasmosis_Homo sapiens_hsa051451.48932797
44Antigen processing and presentation_Homo sapiens_hsa046121.47081612
45Influenza A_Homo sapiens_hsa051641.44912983
46Type I diabetes mellitus_Homo sapiens_hsa049401.44626970
47Insulin resistance_Homo sapiens_hsa049311.44125354
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.43733190
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41333346
50AMPK signaling pathway_Homo sapiens_hsa041521.40565545
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.39137391
52Biosynthesis of amino acids_Homo sapiens_hsa012301.34458302
53Herpes simplex infection_Homo sapiens_hsa051681.33200131
54Phagosome_Homo sapiens_hsa041451.32968109
55Tryptophan metabolism_Homo sapiens_hsa003801.30987472
56Pancreatic cancer_Homo sapiens_hsa052121.29937253
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27981450
58Chronic myeloid leukemia_Homo sapiens_hsa052201.23641631
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21649515
60Fat digestion and absorption_Homo sapiens_hsa049751.21307900
61Legionellosis_Homo sapiens_hsa051341.19157845
62Glucagon signaling pathway_Homo sapiens_hsa049221.17106817
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15297462
64Platelet activation_Homo sapiens_hsa046111.12852850
65TNF signaling pathway_Homo sapiens_hsa046681.12473113
66Insulin signaling pathway_Homo sapiens_hsa049101.11349272
67mTOR signaling pathway_Homo sapiens_hsa041501.11126644
68Hepatitis B_Homo sapiens_hsa051611.10774023
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09539529
70Endocytosis_Homo sapiens_hsa041441.08149114
71Regulation of autophagy_Homo sapiens_hsa041401.05812017
72Central carbon metabolism in cancer_Homo sapiens_hsa052301.05648198
73Arginine biosynthesis_Homo sapiens_hsa002201.05236325
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05171504
75Hepatitis C_Homo sapiens_hsa051601.04497539
76Renal cell carcinoma_Homo sapiens_hsa052111.00142127
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99521301
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98475225
79Pentose phosphate pathway_Homo sapiens_hsa000300.97547725
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95052587
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94566880
82Glycerolipid metabolism_Homo sapiens_hsa005610.94121986
83Apoptosis_Homo sapiens_hsa042100.93984201
84Lysine degradation_Homo sapiens_hsa003100.93228313
85Shigellosis_Homo sapiens_hsa051310.89832396
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89576021
87Prolactin signaling pathway_Homo sapiens_hsa049170.88372840
88FoxO signaling pathway_Homo sapiens_hsa040680.88301612
89Nitrogen metabolism_Homo sapiens_hsa009100.85959661
90Bile secretion_Homo sapiens_hsa049760.85631396
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85570572
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85546467
93Endometrial cancer_Homo sapiens_hsa052130.85380926
94Arachidonic acid metabolism_Homo sapiens_hsa005900.84309941
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82233043
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.81003947
97Butanoate metabolism_Homo sapiens_hsa006500.79955438
98Notch signaling pathway_Homo sapiens_hsa043300.79757128
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.79171557
100Salmonella infection_Homo sapiens_hsa051320.79030732
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78160635
102Linoleic acid metabolism_Homo sapiens_hsa005910.76228945
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75657776
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.72602064
105Viral carcinogenesis_Homo sapiens_hsa052030.71713081
106beta-Alanine metabolism_Homo sapiens_hsa004100.71559334
107Caffeine metabolism_Homo sapiens_hsa002320.71266989
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70873709
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70568044
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70298814
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68278590
112Epstein-Barr virus infection_Homo sapiens_hsa051690.67910176
113Bladder cancer_Homo sapiens_hsa052190.66790156
114ABC transporters_Homo sapiens_hsa020100.66716784
115Pertussis_Homo sapiens_hsa051330.66381416
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64398960
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64096635
118Colorectal cancer_Homo sapiens_hsa052100.64077967
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63036869
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62583885
121MAPK signaling pathway_Homo sapiens_hsa040100.60696580
122VEGF signaling pathway_Homo sapiens_hsa043700.60661870
123Sulfur relay system_Homo sapiens_hsa041220.60595197
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59514892
125Collecting duct acid secretion_Homo sapiens_hsa049660.59156627
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58996831
127Focal adhesion_Homo sapiens_hsa045100.58365895
128Rheumatoid arthritis_Homo sapiens_hsa053230.56228534
129Other glycan degradation_Homo sapiens_hsa005110.55226684
130HTLV-I infection_Homo sapiens_hsa051660.53675084
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53620107
132Rap1 signaling pathway_Homo sapiens_hsa040150.53295953
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52882003
134Oxytocin signaling pathway_Homo sapiens_hsa049210.51132103
135Calcium signaling pathway_Homo sapiens_hsa040200.49452166
136Thyroid cancer_Homo sapiens_hsa052160.49362181
137Acute myeloid leukemia_Homo sapiens_hsa052210.48727027
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48344477
139Amoebiasis_Homo sapiens_hsa051460.47988842
140ErbB signaling pathway_Homo sapiens_hsa040120.47827901
141HIF-1 signaling pathway_Homo sapiens_hsa040660.47689991
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.46807412
143Viral myocarditis_Homo sapiens_hsa054160.46646576
144Prostate cancer_Homo sapiens_hsa052150.46613738
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45776766
146Protein digestion and absorption_Homo sapiens_hsa049740.45712491
147Lysosome_Homo sapiens_hsa041420.45157245
148* Glycerophospholipid metabolism_Homo sapiens_hsa005640.44611870
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44547027
150Asthma_Homo sapiens_hsa053100.44280057
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43890795
152Fatty acid elongation_Homo sapiens_hsa000620.43773590
153Tight junction_Homo sapiens_hsa045300.43240112
154Glioma_Homo sapiens_hsa052140.42331953
155Parkinsons disease_Homo sapiens_hsa050120.42184445
156Arginine and proline metabolism_Homo sapiens_hsa003300.41696288
157Peroxisome_Homo sapiens_hsa041460.41326337
158Phospholipase D signaling pathway_Homo sapiens_hsa040720.38574163
159Proteoglycans in cancer_Homo sapiens_hsa052050.38042364
160Dorso-ventral axis formation_Homo sapiens_hsa043200.36769192
161Non-small cell lung cancer_Homo sapiens_hsa052230.36048995
162GnRH signaling pathway_Homo sapiens_hsa049120.34772508
163Alzheimers disease_Homo sapiens_hsa050100.33232231
164Chemical carcinogenesis_Homo sapiens_hsa052040.32759971
165Inositol phosphate metabolism_Homo sapiens_hsa005620.32583461
166Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32058985
167ECM-receptor interaction_Homo sapiens_hsa045120.31101946
168Ovarian steroidogenesis_Homo sapiens_hsa049130.29981404
169Renin secretion_Homo sapiens_hsa049240.25652207
170Adherens junction_Homo sapiens_hsa045200.25527984
171Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25457715
172Primary bile acid biosynthesis_Homo sapiens_hsa001200.23714319
173Leukocyte transendothelial migration_Homo sapiens_hsa046700.23440697
174Type II diabetes mellitus_Homo sapiens_hsa049300.23186596
175Choline metabolism in cancer_Homo sapiens_hsa052310.22417681
176Complement and coagulation cascades_Homo sapiens_hsa046100.21017452
177Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20557481

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