PHOSPHO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.78093734
2acrosome assembly (GO:0001675)9.69032154
3axonemal dynein complex assembly (GO:0070286)9.39960913
4sperm-egg recognition (GO:0035036)9.33496647
5male meiosis (GO:0007140)8.81147662
6binding of sperm to zona pellucida (GO:0007339)8.72638458
7epithelial cilium movement (GO:0003351)8.60398270
8plasma membrane fusion (GO:0045026)8.32282464
9acrosome reaction (GO:0007340)8.31044063
10cell-cell recognition (GO:0009988)8.28377219
11motile cilium assembly (GO:0044458)8.26767346
12cell wall macromolecule metabolic process (GO:0044036)7.97443992
13cell wall macromolecule catabolic process (GO:0016998)7.97443992
14reproduction (GO:0000003)7.95368607
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.94699374
16spermatid development (GO:0007286)7.61323420
17cilium movement (GO:0003341)7.31900461
18synaptonemal complex organization (GO:0070193)7.23615799
19DNA methylation involved in gamete generation (GO:0043046)7.23077591
20synaptonemal complex assembly (GO:0007130)6.84710031
21single fertilization (GO:0007338)6.71527644
22regulation of cilium movement (GO:0003352)6.28338010
23male meiosis I (GO:0007141)5.93730549
24fertilization (GO:0009566)5.79932692
25spermatogenesis (GO:0007283)5.30021841
26male gamete generation (GO:0048232)5.28757273
27meiotic cell cycle (GO:0051321)5.22952019
28microtubule depolymerization (GO:0007019)5.21389551
29meiotic nuclear division (GO:0007126)5.19433155
30chromosome organization involved in meiosis (GO:0070192)5.14314521
31sperm capacitation (GO:0048240)5.11678723
32gamete generation (GO:0007276)5.02769194
33meiosis I (GO:0007127)4.92629364
34negative regulation of inclusion body assembly (GO:0090084)4.89292644
35microtubule severing (GO:0051013)4.83904574
36proteasome assembly (GO:0043248)4.83802175
37monoubiquitinated protein deubiquitination (GO:0035520)4.63155805
38cellular process involved in reproduction in multicellular organism (GO:0022412)4.50774086
39germ cell development (GO:0007281)4.49940557
40protein localization to cilium (GO:0061512)4.29769202
41seminiferous tubule development (GO:0072520)4.19627703
42regulation of meiosis I (GO:0060631)4.16453502
43DNA double-strand break processing (GO:0000729)4.16366693
44organic cation transport (GO:0015695)4.15466985
45multicellular organismal reproductive process (GO:0048609)3.90794325
46left/right pattern formation (GO:0060972)3.88199123
47calcium ion-dependent exocytosis (GO:0017156)3.86991139
48intraciliary transport (GO:0042073)3.86085151
49cell recognition (GO:0008037)3.86084413
50ventricular system development (GO:0021591)3.81871116
51regulation of inclusion body assembly (GO:0090083)3.81327062
52centriole assembly (GO:0098534)3.79255446
53protein polyglutamylation (GO:0018095)3.78804327
54axoneme assembly (GO:0035082)3.73464480
55chaperone-mediated protein transport (GO:0072321)3.73188533
56meiotic cell cycle process (GO:1903046)3.64815796
57centriole replication (GO:0007099)3.60939546
58regulation of mitotic spindle checkpoint (GO:1903504)3.60451161
59regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.60451161
60cullin deneddylation (GO:0010388)3.59792793
61somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.59551946
62isotype switching (GO:0045190)3.59551946
63somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.59551946
64CENP-A containing nucleosome assembly (GO:0034080)3.52246728
65spermatid nucleus differentiation (GO:0007289)3.46829523
66gene silencing by RNA (GO:0031047)3.45052761
67synapsis (GO:0007129)3.44712620
68protein deneddylation (GO:0000338)3.44246984
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.43024340
70glycerol ether metabolic process (GO:0006662)3.36747708
71lactate metabolic process (GO:0006089)3.35304130
72histone exchange (GO:0043486)3.34056495
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33576324
74protein complex biogenesis (GO:0070271)3.32268962
75mitochondrial respiratory chain complex assembly (GO:0033108)3.29200123
76regulation of spindle checkpoint (GO:0090231)3.28631601
77cilium organization (GO:0044782)3.27682176
78DNA ligation (GO:0006266)3.18801302
79regulation of microtubule-based movement (GO:0060632)3.18450468
80cilium assembly (GO:0042384)3.16867900
81resolution of meiotic recombination intermediates (GO:0000712)3.16256307
82replication fork processing (GO:0031297)3.16080886
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15743422
84mitochondrial respiratory chain complex I assembly (GO:0032981)3.15743422
85NADH dehydrogenase complex assembly (GO:0010257)3.15743422
86cilium morphogenesis (GO:0060271)3.15193338
87GTP biosynthetic process (GO:0006183)3.14078338
88pseudouridine synthesis (GO:0001522)3.13682108
89respiratory chain complex IV assembly (GO:0008535)3.12270274
90polyol catabolic process (GO:0046174)3.10710871
91sister chromatid cohesion (GO:0007062)3.10564622
92protein neddylation (GO:0045116)3.09903490
93regulation of mitochondrial translation (GO:0070129)3.08594569
94ether metabolic process (GO:0018904)3.07974415
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07757038
96maturation of 5.8S rRNA (GO:0000460)3.06380859
97DNA damage response, detection of DNA damage (GO:0042769)3.03861376
98pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03344604
99transcription from mitochondrial promoter (GO:0006390)3.02927076
100multicellular organismal development (GO:0007275)3.01819570
101DNA catabolic process, exonucleolytic (GO:0000738)3.00702087
102histone mRNA metabolic process (GO:0008334)3.00436016
103regulation of helicase activity (GO:0051095)2.99772859
104sequestering of actin monomers (GO:0042989)2.98302688
105mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.97601113
106DNA methylation (GO:0006306)2.97378904
107DNA alkylation (GO:0006305)2.97378904
108mitotic sister chromatid cohesion (GO:0007064)2.96820941
109nucleoside diphosphate phosphorylation (GO:0006165)2.95686160
110transcription elongation from RNA polymerase III promoter (GO:0006385)2.95485380
111termination of RNA polymerase III transcription (GO:0006386)2.95485380
112nucleotide-excision repair, DNA gap filling (GO:0006297)2.95088143
113rRNA modification (GO:0000154)2.92895428
114RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.91523597
115ubiquinone biosynthetic process (GO:0006744)2.91349972
116L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.90488228
117base-excision repair, AP site formation (GO:0006285)2.89428564
118establishment of protein localization to mitochondrial membrane (GO:0090151)2.88109438
119somatic recombination of immunoglobulin gene segments (GO:0016447)2.87597445
120mitochondrial RNA metabolic process (GO:0000959)2.86927355
121branched-chain amino acid catabolic process (GO:0009083)2.86762533
122negative regulation of DNA-dependent DNA replication (GO:2000104)2.85758584
123regulation of acrosome reaction (GO:0060046)2.85532469
124genitalia morphogenesis (GO:0035112)2.84861342
125cellular component assembly involved in morphogenesis (GO:0010927)2.83358896
126DNA replication-independent nucleosome organization (GO:0034724)2.83044447
127DNA replication-independent nucleosome assembly (GO:0006336)2.83044447
128ubiquinone metabolic process (GO:0006743)2.82524181
129cytochrome complex assembly (GO:0017004)2.82422687
130negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80667279
131oxidative phosphorylation (GO:0006119)2.79809053
132protein K11-linked deubiquitination (GO:0035871)2.79576398
133microtubule polymerization or depolymerization (GO:0031109)2.78880704
134somatic diversification of immunoglobulins (GO:0016445)2.76399584
135protein-cofactor linkage (GO:0018065)2.75128053
136regulation of centriole replication (GO:0046599)2.74765172
137protein targeting to mitochondrion (GO:0006626)2.74654065
138female gamete generation (GO:0007292)2.74204700
139regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73924790
140protein K6-linked ubiquitination (GO:0085020)2.71755833
141tRNA methylation (GO:0030488)2.71641059
142chromosome condensation (GO:0030261)2.69181363
143DNA deamination (GO:0045006)2.68787250
144protein K11-linked ubiquitination (GO:0070979)2.68261298
145DNA packaging (GO:0006323)2.67976444
146postreplication repair (GO:0006301)2.67888666
147non-recombinational repair (GO:0000726)2.67701755
148double-strand break repair via nonhomologous end joining (GO:0006303)2.67701755
149tRNA processing (GO:0008033)2.67211962
150positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.67201814
151energy coupled proton transport, down electrochemical gradient (GO:0015985)2.67124357
152ATP synthesis coupled proton transport (GO:0015986)2.67124357
153DNA replication checkpoint (GO:0000076)2.67066835
154histone H2A acetylation (GO:0043968)2.66742893
155microtubule-based movement (GO:0007018)2.63352112
156peptidyl-histidine modification (GO:0018202)2.63062106
157mannosylation (GO:0097502)2.62978162
158pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.62910828
159negative regulation of DNA recombination (GO:0045910)2.62082008
160purine nucleobase biosynthetic process (GO:0009113)2.60318547
161regulation of DNA endoreduplication (GO:0032875)2.59864888
162kinetochore assembly (GO:0051382)2.59839877
163telomere maintenance via semi-conservative replication (GO:0032201)2.59639300
164RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59526678
165tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59526678
166protein localization to mitochondrion (GO:0070585)2.59503227
167spindle checkpoint (GO:0031577)2.59404915
168tRNA metabolic process (GO:0006399)2.59309991
169regulation of nuclear cell cycle DNA replication (GO:0033262)2.59248954
170alditol metabolic process (GO:0019400)2.59232449
171mitotic spindle checkpoint (GO:0071174)2.59021551
172UTP metabolic process (GO:0046051)2.58890887
173anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.58493862
174DNA replication-dependent nucleosome organization (GO:0034723)2.58171659
175DNA replication-dependent nucleosome assembly (GO:0006335)2.58171659
176somatic hypermutation of immunoglobulin genes (GO:0016446)2.57801224
177regulation of meiosis (GO:0040020)2.55467158
178UTP biosynthetic process (GO:0006228)2.51320400
179single strand break repair (GO:0000012)2.49274305
180reciprocal meiotic recombination (GO:0007131)2.48717326
181reciprocal DNA recombination (GO:0035825)2.48717326
182chromatin remodeling at centromere (GO:0031055)2.43655957
183negative regulation of meiosis (GO:0045835)2.43434968
184regulation of female gonad development (GO:2000194)2.42812478
185amino-acid betaine transport (GO:0015838)2.41757282
186cilium or flagellum-dependent cell motility (GO:0001539)11.3092917
187fusion of sperm to egg plasma membrane (GO:0007342)10.9462176
188piRNA metabolic process (GO:0034587)10.8455529
189multicellular organism reproduction (GO:0032504)10.0338967

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.96656706
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.83024112
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.53971464
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.84628383
5EZH2_22144423_ChIP-Seq_EOC_Human3.65215453
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.36288887
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.35341602
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.29253120
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.24999421
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01205132
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.90345819
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85799325
13E2F7_22180533_ChIP-Seq_HELA_Human2.84670858
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.68050206
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66668230
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.60676049
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.57428987
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51087253
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.48935258
20ELK1_19687146_ChIP-ChIP_HELA_Human2.46915614
21IGF1R_20145208_ChIP-Seq_DFB_Human2.45803139
22VDR_23849224_ChIP-Seq_CD4+_Human2.45267737
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43167866
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36197207
25* KAP1_22055183_ChIP-Seq_ESCs_Mouse2.34187118
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.28019901
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15740230
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.13061875
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.11245513
30FOXP3_21729870_ChIP-Seq_TREG_Human2.09673938
31NFE2_27457419_Chip-Seq_LIVER_Mouse2.09052522
32SUZ12_27294783_Chip-Seq_NPCs_Mouse2.06780395
33VDR_22108803_ChIP-Seq_LS180_Human2.05672006
34EWS_26573619_Chip-Seq_HEK293_Human1.93272307
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.89013362
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.88871638
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86014791
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82297241
39* GABP_19822575_ChIP-Seq_HepG2_Human1.79002542
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.77237904
41MYC_18940864_ChIP-ChIP_HL60_Human1.76859656
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75317839
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.71950764
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.69928253
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69475334
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.66206306
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66193779
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66112868
49DCP1A_22483619_ChIP-Seq_HELA_Human1.65861015
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.64583280
51* STAT1_17558387_ChIP-Seq_HELA_Human1.64475536
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63488027
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63259234
54* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.61030733
55TAL1_26923725_Chip-Seq_HPCs_Mouse1.60467027
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59716564
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56646610
58IRF1_19129219_ChIP-ChIP_H3396_Human1.56193998
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55369372
60P53_22387025_ChIP-Seq_ESCs_Mouse1.54905120
61ZNF274_21170338_ChIP-Seq_K562_Hela1.54496439
62STAT3_18555785_Chip-Seq_ESCs_Mouse1.53186019
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.52766256
64TAF15_26573619_Chip-Seq_HEK293_Human1.52690582
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52294236
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50553556
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.50193866
68TTF2_22483619_ChIP-Seq_HELA_Human1.49764334
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.48357472
70OCT4_18555785_Chip-Seq_ESCs_Mouse1.48219984
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47548104
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46954487
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.46783090
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45666945
75RNF2_27304074_Chip-Seq_NSC_Mouse1.45435013
76NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44744767
77TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.44360789
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41159389
79GATA1_26923725_Chip-Seq_HPCs_Mouse1.40873158
80KDM2B_26808549_Chip-Seq_REH_Human1.40633620
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.40625858
82KLF4_18555785_Chip-Seq_ESCs_Mouse1.39430451
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39286886
84P300_18555785_Chip-Seq_ESCs_Mouse1.38941438
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.38608712
86ESRRB_18555785_Chip-Seq_ESCs_Mouse1.36534904
87* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36058318
88ELK4_26923725_Chip-Seq_MESODERM_Mouse1.34344917
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.34244890
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34148415
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33829647
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31550087
93RUNX1_27457419_Chip-Seq_LIVER_Mouse1.31448973
94NMYC_18555785_Chip-Seq_ESCs_Mouse1.31297012
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.31234100
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31021016
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30701779
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.30670474
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29851588
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29851588
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29061067
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28180670
103ZFX_18555785_Chip-Seq_ESCs_Mouse1.26087157
104PU1_27457419_Chip-Seq_LIVER_Mouse1.25889944
105CTCF_18555785_Chip-Seq_ESCs_Mouse1.25320653
106CBP_20019798_ChIP-Seq_JUKART_Human1.24514040
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24514040
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24483152
109* GATA3_21867929_ChIP-Seq_TH1_Mouse1.23687881
110GATA3_21867929_ChIP-Seq_CD8_Mouse1.23466360
111GBX2_23144817_ChIP-Seq_PC3_Human1.23370689
112E2F1_21310950_ChIP-Seq_MCF-7_Human1.22470293
113FUS_26573619_Chip-Seq_HEK293_Human1.20961087
114MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20349900
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18787209
116SMAD1_18555785_Chip-Seq_ESCs_Mouse1.17386122
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.16638970
118TP63_19390658_ChIP-ChIP_HaCaT_Human1.16374864
119RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16144543
120YY1_21170310_ChIP-Seq_MESCs_Mouse1.15999557
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15900603
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15588905
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13335807
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11958896
125ERG_20517297_ChIP-Seq_VCAP_Human1.10847960
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10842989
127RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10769382
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08359516
129XRN2_22483619_ChIP-Seq_HELA_Human1.08147966
130ER_23166858_ChIP-Seq_MCF-7_Human1.08106379
131MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07859823
132KDM5A_27292631_Chip-Seq_BREAST_Human1.06838692
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06829087
134GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.04863441
135WDR5_24793694_ChIP-Seq_LNCAP_Human1.04685145
136SOX2_22085726_ChIP-Seq_NPCs_Mouse1.04365003
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04320219
138SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.04222130
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01829289
140NOTCH1_21737748_ChIP-Seq_TLL_Human1.01421558
141SOX2_16153702_ChIP-ChIP_HESCs_Human1.01249568
142GF1_26923725_Chip-Seq_HPCs_Mouse1.00580751
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99772485
144* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99466305
145POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97775535
146CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96989714
147E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96538901
148SMAD4_21799915_ChIP-Seq_A2780_Human0.95422197
149SOX2_19829295_ChIP-Seq_ESCs_Human0.95322448
150NANOG_19829295_ChIP-Seq_ESCs_Human0.95322448
151TCF4_23295773_ChIP-Seq_U87_Human0.94955238
152AR_21909140_ChIP-Seq_LNCAP_Human0.94880965
153MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94132326
154KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93909462
155CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93161338
156FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92788855
157EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92005292
158NANOG_16153702_ChIP-ChIP_HESCs_Human0.91577544
159UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91125034
160FOXA1_25329375_ChIP-Seq_VCAP_Human0.90584475
161FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90584475
162FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90090843
163P300_19829295_ChIP-Seq_ESCs_Human0.89014787
164GF1B_26923725_Chip-Seq_HPCs_Mouse0.87990232
165AR_20517297_ChIP-Seq_VCAP_Human0.87601990
166SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86362794
167HTT_18923047_ChIP-ChIP_STHdh_Human0.86000558
168SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85330178
169TP53_22573176_ChIP-Seq_HFKS_Human0.84607101
170REST_21632747_ChIP-Seq_MESCs_Mouse0.84229386
171LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84051818
172ESET_19884257_ChIP-Seq_ESCs_Mouse0.82891177
173ETV1_20927104_ChIP-Seq_GIST48_Human0.82352431
174CDX2_22108803_ChIP-Seq_LS180_Human0.81217490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.59631023
2MP0001929_abnormal_gametogenesis5.02076222
3MP0003698_abnormal_male_reproductive4.81038672
4MP0002210_abnormal_sex_determination3.58321243
5MP0003646_muscle_fatigue3.31659784
6MP0008789_abnormal_olfactory_epithelium3.04991193
7MP0001145_abnormal_male_reproductive2.88510206
8MP0000653_abnormal_sex_gland2.88155920
9MP0002161_abnormal_fertility/fecundity2.85696040
10MP0002102_abnormal_ear_morphology2.56159589
11MP0005394_taste/olfaction_phenotype2.50054952
12MP0005499_abnormal_olfactory_system2.50054952
13MP0005646_abnormal_pituitary_gland2.19831407
14MP0005645_abnormal_hypothalamus_physiol2.16296817
15MP0003121_genomic_imprinting2.13729153
16MP0010094_abnormal_chromosome_stability2.13093330
17MP0002653_abnormal_ependyma_morphology2.12213397
18MP0008058_abnormal_DNA_repair2.11301128
19MP0005410_abnormal_fertilization11.2943126
20MP0003718_maternal_effect1.85179889
21MP0008057_abnormal_DNA_replication1.77266343
22MP0002160_abnormal_reproductive_system1.71073986
23MP0003693_abnormal_embryo_hatching1.70421348
24MP0001986_abnormal_taste_sensitivity1.68902826
25MP0008007_abnormal_cellular_replicative1.68564577
26MP0009697_abnormal_copulation1.68138502
27MP0000015_abnormal_ear_pigmentation1.66683447
28MP0003186_abnormal_redox_activity1.60746946
29MP0003122_maternal_imprinting1.59484302
30MP0003195_calcinosis1.54848214
31MP0002822_catalepsy1.52145108
32MP0002234_abnormal_pharynx_morphology1.51230364
33MP0001119_abnormal_female_reproductive1.46046749
34MP0008932_abnormal_embryonic_tissue1.45914600
35MP0002938_white_spotting1.45072779
36MP0003786_premature_aging1.43560710
37MP0005389_reproductive_system_phenotype1.34887033
38MP0003111_abnormal_nucleus_morphology1.32198094
39MP0006292_abnormal_olfactory_placode1.30889967
40MP0003011_delayed_dark_adaptation1.28322831
41MP0005647_abnormal_sex_gland1.27051607
42MP0008995_early_reproductive_senescence1.26409506
43MP0001984_abnormal_olfaction1.25851477
44MP0003699_abnormal_female_reproductive1.24450017
45MP0003937_abnormal_limbs/digits/tail_de1.14075827
46MP0003806_abnormal_nucleotide_metabolis1.13943466
47MP0004133_heterotaxia1.12296254
48MP0001293_anophthalmia1.08810775
49MP0003787_abnormal_imprinting1.05799039
50MP0003077_abnormal_cell_cycle1.05524314
51MP0001545_abnormal_hematopoietic_system1.05437525
52MP0005397_hematopoietic_system_phenotyp1.05437525
53MP0002233_abnormal_nose_morphology1.04168966
54MP0005670_abnormal_white_adipose1.03973714
55MP0005451_abnormal_body_composition1.03599990
56MP0002751_abnormal_autonomic_nervous1.02172155
57MP0001529_abnormal_vocalization1.01964737
58MP0000516_abnormal_urinary_system0.99164268
59MP0005367_renal/urinary_system_phenotyp0.99164268
60MP0004142_abnormal_muscle_tone0.96612472
61MP0001764_abnormal_homeostasis0.95891117
62MP0003567_abnormal_fetal_cardiomyocyte0.94841704
63MP0005220_abnormal_exocrine_pancreas0.93672762
64MP0002638_abnormal_pupillary_reflex0.91046326
65MP0001765_abnormal_ion_homeostasis0.90307381
66MP0002090_abnormal_vision0.90043018
67MP0001905_abnormal_dopamine_level0.89906500
68MP0004147_increased_porphyrin_level0.89364094
69MP0008260_abnormal_autophagy0.88421760
70MP0005636_abnormal_mineral_homeostasis0.88103599
71MP0000778_abnormal_nervous_system0.87654063
72MP0003890_abnormal_embryonic-extraembry0.87226990
73MP0005365_abnormal_bile_salt0.87108443
74MP0005551_abnormal_eye_electrophysiolog0.86910922
75MP0004043_abnormal_pH_regulation0.86241315
76MP0005332_abnormal_amino_acid0.85774297
77MP0000049_abnormal_middle_ear0.85418454
78MP0002557_abnormal_social/conspecific_i0.85345000
79MP0005408_hypopigmentation0.85154070
80MP0003763_abnormal_thymus_physiology0.84984644
81MP0002736_abnormal_nociception_after0.83172810
82MP0005085_abnormal_gallbladder_physiolo0.82028272
83MP0003123_paternal_imprinting0.80596433
84MP0001727_abnormal_embryo_implantation0.80211701
85MP0008872_abnormal_physiological_respon0.79614003
86MP0002272_abnormal_nervous_system0.79483937
87MP0003941_abnormal_skin_development0.77937011
88MP0001188_hyperpigmentation0.77090707
89MP0001919_abnormal_reproductive_system0.76398509
90MP0002876_abnormal_thyroid_physiology0.76202731
91MP0000569_abnormal_digit_pigmentation0.76197628
92MP0001485_abnormal_pinna_reflex0.75416527
93MP0006036_abnormal_mitochondrial_physio0.74897615
94MP0002184_abnormal_innervation0.74543158
95MP0005395_other_phenotype0.73943905
96MP0002282_abnormal_trachea_morphology0.73432811
97MP0005075_abnormal_melanosome_morpholog0.73363132
98MP0000647_abnormal_sebaceous_gland0.73317756
99MP0002132_abnormal_respiratory_system0.73178532
100MP0005195_abnormal_posterior_eye0.72695358
101MP0002229_neurodegeneration0.71512763
102MP0005386_behavior/neurological_phenoty0.70622364
103MP0004924_abnormal_behavior0.70622364
104MP0005391_vision/eye_phenotype0.69478543
105MP0002752_abnormal_somatic_nervous0.69125926
106MP0002928_abnormal_bile_duct0.68442363
107MP0006276_abnormal_autonomic_nervous0.67168089
108MP0004808_abnormal_hematopoietic_stem0.66608090
109MP0001324_abnormal_eye_pigmentation0.66530081
110MP0003880_abnormal_central_pattern0.64692182
111MP0002095_abnormal_skin_pigmentation0.64490786
112MP0001835_abnormal_antigen_presentation0.63781565
113MP0003724_increased_susceptibility_to0.61498180
114MP0005174_abnormal_tail_pigmentation0.60576754
115MP0002139_abnormal_hepatobiliary_system0.58553959
116MP0006072_abnormal_retinal_apoptosis0.56233170
117MP0001502_abnormal_circadian_rhythm0.56209967
118MP0005253_abnormal_eye_physiology0.55317189
119MP0003879_abnormal_hair_cell0.54818286
120MP0009046_muscle_twitch0.52766475
121MP0003656_abnormal_erythrocyte_physiolo0.50978937
122MP0009785_altered_susceptibility_to0.50859827
123MP0005671_abnormal_response_to0.49536512
124MP0008875_abnormal_xenobiotic_pharmacok0.46838837
125MP0000427_abnormal_hair_cycle0.46615012
126MP0000631_abnormal_neuroendocrine_gland0.46556300
127MP0005360_urolithiasis0.46168241
128MP0002693_abnormal_pancreas_physiology0.45325525
129MP0001968_abnormal_touch/_nociception0.44690076
130MP0005310_abnormal_salivary_gland0.42847380
131MP0010386_abnormal_urinary_bladder0.42578764
132MP0000313_abnormal_cell_death0.42514491
133MP0003950_abnormal_plasma_membrane0.42442848
134MP0005084_abnormal_gallbladder_morpholo0.42167380
135MP0004957_abnormal_blastocyst_morpholog0.40452519
136MP0003943_abnormal_hepatobiliary_system0.39161602
137MP0005379_endocrine/exocrine_gland_phen0.38739193
138MP0002398_abnormal_bone_marrow0.36335011
139MP0006035_abnormal_mitochondrial_morpho0.35691708
140MP0003136_yellow_coat_color0.35445486
141MP0000358_abnormal_cell_content/0.35119619
142MP0002163_abnormal_gland_morphology0.34656406
143MP0000372_irregular_coat_pigmentation0.33541583
144MP0002837_dystrophic_cardiac_calcinosis0.33118613
145MP0002019_abnormal_tumor_incidence0.32013822

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.40537233
2Abnormal respiratory motile cilium morphology (HP:0005938)7.84626279
3Abnormal respiratory epithelium morphology (HP:0012253)7.84626279
4Rhinitis (HP:0012384)6.91018096
5Abnormal ciliary motility (HP:0012262)6.83383787
6Chronic bronchitis (HP:0004469)6.41442893
7Infertility (HP:0000789)5.60804957
8Nasal polyposis (HP:0100582)4.60923550
9Bronchiectasis (HP:0002110)4.23924754
10Nephronophthisis (HP:0000090)4.19542125
11Tubulointerstitial nephritis (HP:0001970)3.82962917
12Bronchitis (HP:0012387)3.74748871
13Acute necrotizing encephalopathy (HP:0006965)3.66159307
14Abnormality of the nasal mucosa (HP:0000433)3.62968498
15Male infertility (HP:0003251)3.58013475
16Abnormality of the renal medulla (HP:0100957)3.52703963
17Acute encephalopathy (HP:0006846)3.50946249
18Volvulus (HP:0002580)3.46515019
19Recurrent sinusitis (HP:0011108)3.42937914
20Abnormal mitochondria in muscle tissue (HP:0008316)3.40612548
21Abnormality of midbrain morphology (HP:0002418)3.37037482
22Molar tooth sign on MRI (HP:0002419)3.37037482
23Hepatocellular necrosis (HP:0001404)3.18216408
24Abnormal spermatogenesis (HP:0008669)3.15842699
25Medial flaring of the eyebrow (HP:0010747)3.13040890
26Progressive macrocephaly (HP:0004481)3.12057091
27Intestinal atresia (HP:0011100)3.10370862
28Mitochondrial inheritance (HP:0001427)3.09801274
29Hepatic necrosis (HP:0002605)3.06391558
30Increased CSF lactate (HP:0002490)3.00614559
31Abnormality of the labia minora (HP:0012880)2.95870569
32Pancreatic fibrosis (HP:0100732)2.88267021
33Recurrent otitis media (HP:0000403)2.77359903
34Tubulointerstitial abnormality (HP:0001969)2.64490011
35Cerebral edema (HP:0002181)2.61658889
36Azoospermia (HP:0000027)2.53058259
37Abnormality of the renal cortex (HP:0011035)2.50468998
38Postaxial foot polydactyly (HP:0001830)2.44698343
39Increased serum lactate (HP:0002151)2.44395527
40Colon cancer (HP:0003003)2.43079200
41Methylmalonic acidemia (HP:0002912)2.42928243
42Vaginal atresia (HP:0000148)2.42506699
43Increased serum pyruvate (HP:0003542)2.41565150
44Gonadotropin excess (HP:0000837)2.40934817
45Fibular hypoplasia (HP:0003038)2.39066619
46Hyperglycinemia (HP:0002154)2.38998519
47Increased hepatocellular lipid droplets (HP:0006565)2.31280580
48Abnormality of the ileum (HP:0001549)2.30655441
49Supernumerary spleens (HP:0009799)2.30395947
50True hermaphroditism (HP:0010459)2.30212648
51Neoplasm of the adrenal gland (HP:0100631)2.27949343
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27875295
53Abnormality of alanine metabolism (HP:0010916)2.27875295
54Hyperalaninemia (HP:0003348)2.27875295
55Congenital hepatic fibrosis (HP:0002612)2.26877932
56Lipid accumulation in hepatocytes (HP:0006561)2.25174498
57Lactic acidosis (HP:0003128)2.24047905
58Impulsivity (HP:0100710)2.20994315
59Type I transferrin isoform profile (HP:0003642)2.19878418
60Neoplasm of the adrenal cortex (HP:0100641)2.17201834
61Abnormal protein glycosylation (HP:0012346)2.14926331
62Abnormal glycosylation (HP:0012345)2.14926331
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14926331
64Abnormal protein N-linked glycosylation (HP:0012347)2.14926331
65Pancreatic cysts (HP:0001737)2.12833038
66Congenital primary aphakia (HP:0007707)2.12709618
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12643821
68Cystic liver disease (HP:0006706)2.12277567
69CNS demyelination (HP:0007305)2.08244932
70Reduced antithrombin III activity (HP:0001976)2.08187430
71Gait imbalance (HP:0002141)2.06811705
72Decreased testicular size (HP:0008734)2.06104679
73Birth length less than 3rd percentile (HP:0003561)2.05111633
74Chromsome breakage (HP:0040012)2.05018013
75Hypothermia (HP:0002045)2.04407902
76Cerebral hypomyelination (HP:0006808)2.03916188
77Nephrogenic diabetes insipidus (HP:0009806)2.01657285
78Abnormality of the lower motor neuron (HP:0002366)2.01209972
79Abnormality of glycolysis (HP:0004366)2.00904706
80Hyperglycinuria (HP:0003108)2.00588293
81Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00158213
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0178811
83Absent/shortened dynein arms (HP:0200106)10.7368518
84Dynein arm defect of respiratory motile cilia (HP:0012255)10.7368518
85Sclerocornea (HP:0000647)1.98920344
86Abolished electroretinogram (ERG) (HP:0000550)1.97880343
87Recurrent bronchitis (HP:0002837)1.96952857
88Tubular atrophy (HP:0000092)1.96649613
89Methylmalonic aciduria (HP:0012120)1.95173745
90Optic neuritis (HP:0100653)1.93550891
91Retrobulbar optic neuritis (HP:0100654)1.93550891
92Bile duct proliferation (HP:0001408)1.93355019
93Abnormal biliary tract physiology (HP:0012439)1.93355019
94Renal Fanconi syndrome (HP:0001994)1.92836526
953-Methylglutaconic aciduria (HP:0003535)1.92070219
96Degeneration of anterior horn cells (HP:0002398)1.92015588
97Abnormality of the anterior horn cell (HP:0006802)1.92015588
98Lethargy (HP:0001254)1.90893117
99Oculomotor apraxia (HP:0000657)1.87478169
100Abnormality of serine family amino acid metabolism (HP:0010894)1.87253928
101Abnormality of glycine metabolism (HP:0010895)1.87253928
102Respiratory failure (HP:0002878)1.86727669
103Optic disc pallor (HP:0000543)1.86191213
104Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83823642
105Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83823642
106Abnormal lung lobation (HP:0002101)1.83555541
107Oligodactyly (hands) (HP:0001180)1.83504989
108Pancreatic islet-cell hyperplasia (HP:0004510)1.83333790
109Bifid tongue (HP:0010297)1.81524969
110Poor coordination (HP:0002370)1.80239660
111Growth hormone deficiency (HP:0000824)1.80230042
112Renal dysplasia (HP:0000110)1.79174565
113Astigmatism (HP:0000483)1.78441109
114Aplasia/Hypoplasia of the fibula (HP:0006492)1.77183927
115Impaired proprioception (HP:0010831)1.76994116
116Aplasia/Hypoplasia of the tongue (HP:0010295)1.76193988
117Abnormality of serum amino acid levels (HP:0003112)1.74705741
118Increased intramyocellular lipid droplets (HP:0012240)1.74617421
11911 pairs of ribs (HP:0000878)1.74571498
120Abnormality of the duodenum (HP:0002246)1.74537912
121Aganglionic megacolon (HP:0002251)1.74301274
122Gastrointestinal atresia (HP:0002589)1.74012511
123Postaxial hand polydactyly (HP:0001162)1.73322911
124Broad foot (HP:0001769)1.72835628
125Duodenal stenosis (HP:0100867)1.72227438
126Small intestinal stenosis (HP:0012848)1.72227438
127Chronic sinusitis (HP:0011109)1.72219846
128Facial cleft (HP:0002006)1.72213034
129Chronic hepatic failure (HP:0100626)1.71911380
130Aplasia/Hypoplasia of the uvula (HP:0010293)1.71675364
131Stomatitis (HP:0010280)1.70249351
132Tubulointerstitial fibrosis (HP:0005576)1.66180667
133Stage 5 chronic kidney disease (HP:0003774)1.64835610
134Median cleft lip (HP:0000161)1.63416416
135Abnormal drinking behavior (HP:0030082)1.61532919
136Polydipsia (HP:0001959)1.61532919
137Abnormality of renal resorption (HP:0011038)1.59999015
138Sloping forehead (HP:0000340)1.59224797
139Dyschromatopsia (HP:0007641)1.58629167
140Abnormality of the preputium (HP:0100587)1.58201424
141Abnormality of permanent molar morphology (HP:0011071)1.57087212
142Abnormality of the dental root (HP:0006486)1.57087212
143Taurodontia (HP:0000679)1.57087212
144Amyotrophic lateral sclerosis (HP:0007354)1.56672323
145Aplasia/Hypoplasia of the lens (HP:0008063)1.56334411
146Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.54955434
147Absent epiphyses (HP:0010577)1.54955434
148Abnormality of chromosome stability (HP:0003220)1.53833330
149Clubbing of toes (HP:0100760)1.52239059
150Nephroblastoma (Wilms tumor) (HP:0002667)1.51348430
151Decreased central vision (HP:0007663)1.51150264
152Type 2 muscle fiber atrophy (HP:0003554)1.50375557
153Upper motor neuron abnormality (HP:0002127)1.48552176
154Hypergonadotropic hypogonadism (HP:0000815)1.48339666
155Renal cortical cysts (HP:0000803)1.46686343
156Abnormality of molar morphology (HP:0011070)1.46079935
157Abnormality of molar (HP:0011077)1.46079935
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.46004382
159Abnormality of the dental pulp (HP:0006479)1.42948201
160Embryonal renal neoplasm (HP:0011794)1.41792100
161Male pseudohermaphroditism (HP:0000037)1.40617277
162Abnormality of renal excretion (HP:0011036)1.39797552
163Genital tract atresia (HP:0001827)1.39416186
164Short femoral neck (HP:0100864)1.38267635
165Short nail (HP:0001799)1.37933221
166Preaxial hand polydactyly (HP:0001177)1.37567946
167Nephropathy (HP:0000112)1.36998841
168Meckel diverticulum (HP:0002245)1.35848357

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.90478507
2PDK47.90478507
3PDK24.97854018
4MAP4K23.27116085
5WNK32.93352098
6TRIM282.90850478
7TESK12.78726906
8PRKD32.50907821
9BCKDK2.36459695
10PLK42.30389895
11VRK22.12380776
12STK38L2.05656038
13MUSK2.05456366
14BMPR1B2.04366886
15NEK11.98519058
16BCR1.90091593
17TTK1.75836960
18EIF2AK31.75654535
19PBK1.74984123
20CSNK1G31.74500974
21CCNB11.73239571
22MAP2K71.70219474
23BRAF1.68731049
24CSNK1G11.65202657
25ACVR1B1.63714204
26MST41.61153530
27NEK21.60999651
28CSNK1G21.58069156
29CSNK1A1L1.53382089
30PTK2B1.52511374
31CASK1.43356409
32MKNK21.38683839
33STK381.36005177
34MKNK11.35143904
35CDK191.32768956
36PINK11.31610948
37CHEK21.29357582
38ERBB31.27447572
39TAF11.24815229
40MAP3K61.21037364
41STK161.17622624
42STK31.16746903
43WNK41.15928152
44TAOK31.14613559
45TSSK61.14021207
46TXK1.13461403
47ERBB41.06225187
48LATS11.05761426
49NME11.05213175
50RPS6KA41.04384932
51CDK81.04315685
52LIMK10.96400925
53CDC70.96194932
54DYRK30.95355185
55EPHA40.93618791
56ZAK0.91790161
57BRSK20.91021281
58BMPR20.89731047
59NLK0.82911298
60STK390.81961703
61FLT30.79609217
62PLK10.77571426
63OXSR10.74121253
64MINK10.73009295
65WEE10.72514489
66MAP3K40.70337714
67FRK0.69737953
68IRAK10.66979218
69ICK0.66831946
70CDK30.66606148
71GRK10.64266022
72ATR0.63868741
73AKT30.63473045
74DAPK10.63015726
75INSRR0.62292782
76SGK20.62180650
77MAPK150.60537584
78MAPK130.60395890
79SRPK10.59479517
80PDK10.59207577
81BUB10.58807261
82VRK10.58538948
83MAP3K120.58064593
84MAPKAPK50.57984991
85RPS6KA50.57756428
86MARK10.56787295
87MELK0.56468336
88PRKCG0.56384740
89YES10.55857298
90NEK90.52863336
91PASK0.52111599
92NTRK30.51831752
93CSNK1E0.51782813
94CSNK2A20.51557517
95EIF2AK20.51449433
96TEC0.51149773
97ATM0.49448992
98PRKCE0.48442140
99TIE10.48292054
100EIF2AK10.47775343
101CAMK2D0.47276473
102MAP3K130.46220454
103MAPKAPK30.45794458
104MAP3K50.44896176
105CDK90.44588299
106KIT0.44574565
107CDK70.44543311
108PAK30.44404317
109PLK30.44237883
110CSNK1A10.43773076
111IKBKE0.43546694
112PRKCI0.42565052
113CHEK10.41070234
114PIM20.40433998
115DYRK20.39361913
116TNIK0.39206393
117SIK30.38805954
118CSNK1D0.38552794
119IRAK40.36639608
120UHMK10.35680868
121CDK10.34762496
122CDK20.34580163
123DYRK1B0.33913919
124PRKAA10.33065406
125LATS20.32298845
126IRAK20.29968519
127PNCK0.29731275
128RPS6KB10.28970497
129STK240.28967002
130EEF2K0.26117356
131MARK30.23794855
132PRKAA20.23450858
133TGFBR10.23090505
134AURKB0.21719425
135NEK60.20951415
136AURKA0.20593192
137PLK20.20234859
138CAMK2A0.19574111
139NUAK10.19088685
140SGK2230.18965705
141SGK4940.18965705
142ADRBK20.17797707
143BRSK10.16529013
144RAF10.15617271
145WNK10.15400070
146MAP4K10.14691818
147MAP2K60.14496820
148CSNK2A10.13948327
149NTRK20.12853003

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.71977945
2Fanconi anemia pathway_Homo sapiens_hsa034604.12530296
3Pyruvate metabolism_Homo sapiens_hsa006203.63041520
4Propanoate metabolism_Homo sapiens_hsa006403.14312381
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.93501356
6Linoleic acid metabolism_Homo sapiens_hsa005912.88849438
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.88094430
8Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.66766719
9Homologous recombination_Homo sapiens_hsa034402.47392729
10RNA degradation_Homo sapiens_hsa030182.35553349
11Parkinsons disease_Homo sapiens_hsa050122.27272195
12Butanoate metabolism_Homo sapiens_hsa006502.07369566
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06872551
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.02676212
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00957144
16Huntingtons disease_Homo sapiens_hsa050161.98745209
17Cell cycle_Homo sapiens_hsa041101.98200003
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95913201
19Fatty acid biosynthesis_Homo sapiens_hsa000611.95731615
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.95681220
21Selenocompound metabolism_Homo sapiens_hsa004501.94015773
22Purine metabolism_Homo sapiens_hsa002301.92264875
23Glucagon signaling pathway_Homo sapiens_hsa049221.91486150
24Pentose phosphate pathway_Homo sapiens_hsa000301.87607305
25Oocyte meiosis_Homo sapiens_hsa041141.80661872
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77136086
27Ether lipid metabolism_Homo sapiens_hsa005651.72011158
28Steroid biosynthesis_Homo sapiens_hsa001001.69163258
29Spliceosome_Homo sapiens_hsa030401.65820340
30Nucleotide excision repair_Homo sapiens_hsa034201.64621787
31Base excision repair_Homo sapiens_hsa034101.64586932
32Fatty acid elongation_Homo sapiens_hsa000621.62658187
33Pyrimidine metabolism_Homo sapiens_hsa002401.60215422
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59107235
35RNA transport_Homo sapiens_hsa030131.48190747
36One carbon pool by folate_Homo sapiens_hsa006701.46788492
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.42587594
38mRNA surveillance pathway_Homo sapiens_hsa030151.41945298
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36373275
40Glycerolipid metabolism_Homo sapiens_hsa005611.33403525
41Non-homologous end-joining_Homo sapiens_hsa034501.30493642
42RNA polymerase_Homo sapiens_hsa030201.29525907
43Circadian rhythm_Homo sapiens_hsa047101.26599368
44Ribosome_Homo sapiens_hsa030101.25377132
45Ovarian steroidogenesis_Homo sapiens_hsa049131.23749663
46Dorso-ventral axis formation_Homo sapiens_hsa043201.23265975
47Folate biosynthesis_Homo sapiens_hsa007901.18850546
48DNA replication_Homo sapiens_hsa030301.15318362
49Arachidonic acid metabolism_Homo sapiens_hsa005901.10714470
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09361640
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08860518
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08652384
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.02602918
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00181297
55Protein export_Homo sapiens_hsa030600.97802006
56PPAR signaling pathway_Homo sapiens_hsa033200.92823363
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90692203
58Phototransduction_Homo sapiens_hsa047440.90680129
59Amphetamine addiction_Homo sapiens_hsa050310.90187338
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88010210
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.87603271
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86291405
63Glutathione metabolism_Homo sapiens_hsa004800.84173236
64Proteasome_Homo sapiens_hsa030500.81987923
65p53 signaling pathway_Homo sapiens_hsa041150.78613680
66Peroxisome_Homo sapiens_hsa041460.78222078
67ABC transporters_Homo sapiens_hsa020100.74357302
68Sulfur relay system_Homo sapiens_hsa041220.73790300
69Caffeine metabolism_Homo sapiens_hsa002320.73516437
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73512098
71Fat digestion and absorption_Homo sapiens_hsa049750.72983526
72Sphingolipid metabolism_Homo sapiens_hsa006000.72722627
73Fatty acid degradation_Homo sapiens_hsa000710.72095677
74* Metabolic pathways_Homo sapiens_hsa011000.71295075
75Antigen processing and presentation_Homo sapiens_hsa046120.70719229
76Taste transduction_Homo sapiens_hsa047420.70511570
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70238031
78Tryptophan metabolism_Homo sapiens_hsa003800.69865208
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69066473
80Mismatch repair_Homo sapiens_hsa034300.68482969
81Collecting duct acid secretion_Homo sapiens_hsa049660.67207962
82Inositol phosphate metabolism_Homo sapiens_hsa005620.64509293
83Measles_Homo sapiens_hsa051620.60435064
84Fructose and mannose metabolism_Homo sapiens_hsa000510.59310514
85Carbon metabolism_Homo sapiens_hsa012000.58874242
86Oxidative phosphorylation_Homo sapiens_hsa001900.56940950
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56359157
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56310006
89beta-Alanine metabolism_Homo sapiens_hsa004100.55277475
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54686846
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54361617
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.51384646
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50575707
94Fatty acid metabolism_Homo sapiens_hsa012120.49645630
95Sulfur metabolism_Homo sapiens_hsa009200.49331765
96Long-term potentiation_Homo sapiens_hsa047200.47731497
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47534082
98Nicotine addiction_Homo sapiens_hsa050330.47458639
99Retinol metabolism_Homo sapiens_hsa008300.47250601
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46037915
101Herpes simplex infection_Homo sapiens_hsa051680.45720456
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44954088
103Primary immunodeficiency_Homo sapiens_hsa053400.44057943
104Olfactory transduction_Homo sapiens_hsa047400.44008571
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41578811
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.41112181
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40373955
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40351276
109Legionellosis_Homo sapiens_hsa051340.39344743
110Cardiac muscle contraction_Homo sapiens_hsa042600.38935420
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38661931
112Regulation of autophagy_Homo sapiens_hsa041400.37416639
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36947587
114Influenza A_Homo sapiens_hsa051640.36904737
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36848024
116Chemical carcinogenesis_Homo sapiens_hsa052040.35810269
117Renin secretion_Homo sapiens_hsa049240.35797042
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35159240
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35029657
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34815614
121Arginine and proline metabolism_Homo sapiens_hsa003300.33518827
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33479152
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33427602
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.32526076
125Rheumatoid arthritis_Homo sapiens_hsa053230.32379168
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32326722
127Arginine biosynthesis_Homo sapiens_hsa002200.31806488
128Alzheimers disease_Homo sapiens_hsa050100.31060371
129Calcium signaling pathway_Homo sapiens_hsa040200.30051845
130Vitamin digestion and absorption_Homo sapiens_hsa049770.29699577
131N-Glycan biosynthesis_Homo sapiens_hsa005100.29408851
132Tyrosine metabolism_Homo sapiens_hsa003500.27099670
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.26263250
134GABAergic synapse_Homo sapiens_hsa047270.25775437
135Biosynthesis of amino acids_Homo sapiens_hsa012300.25767569
136Other glycan degradation_Homo sapiens_hsa005110.25553650
137Epstein-Barr virus infection_Homo sapiens_hsa051690.24996340
138Autoimmune thyroid disease_Homo sapiens_hsa053200.24652698
139Systemic lupus erythematosus_Homo sapiens_hsa053220.23463927
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.23102953
141Graft-versus-host disease_Homo sapiens_hsa053320.22328096
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22068215

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