ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	9.93190414
2	enteric nervous system development (GO:0048484)	9.03242570
3	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	7.89514594
4	coronary vasculature morphogenesis (GO:0060977)	7.83612561
5	regulation of cardioblast proliferation (GO:0003264)	7.70836580
6	regulation of secondary heart field cardioblast proliferation (GO:0003266)	7.70836580
7	cell migration in hindbrain (GO:0021535)	6.70386151
8	neurotransmitter catabolic process (GO:0042135)	6.59619860
9	negative regulation of striated muscle cell apoptotic process (GO:0010664)	6.40712734
10	catecholamine biosynthetic process (GO:0042423)	6.33059679
11	catechol-containing compound biosynthetic process (GO:0009713)	6.33059679
12	negative regulation of cell aging (GO:0090344)	6.21408015
13	norepinephrine metabolic process (GO:0042415)	6.18386076
14	ganglion development (GO:0061548)	6.15386945
15	positive regulation of transcription regulatory region DNA binding (GO:2000679)	6.08452762
16	synaptic transmission, cholinergic (GO:0007271)	6.02557341
17	negative regulation of dendrite morphogenesis (GO:0050774)	5.95322137
18	dopamine metabolic process (GO:0042417)	5.75236063
19	cell migration involved in heart development (GO:0060973)	5.67776475
20	behavioral response to ethanol (GO:0048149)	5.64396888
21	cardiac ventricle formation (GO:0003211)	5.62562728
22	cardiac chamber formation (GO:0003207)	5.47095732
23	positive regulation of glomerulus development (GO:0090193)	5.27688790
24	endocardial cushion morphogenesis (GO:0003203)	5.23264644
25	regulation of cardiac muscle cell apoptotic process (GO:0010665)	5.12382667
26	dopamine biosynthetic process (GO:0042416)	5.03609364
27	* dopaminergic neuron differentiation (GO:0071542)	5.00267765
28	regulation of cell maturation (GO:1903429)	4.91276750
29	tongue development (GO:0043586)	4.87356198
30	peripheral nervous system neuron development (GO:0048935)	4.87266765
31	neurotransmitter biosynthetic process (GO:0042136)	4.83650774
32	regulation of striated muscle cell apoptotic process (GO:0010662)	4.72698911
33	mesenchymal cell proliferation (GO:0010463)	4.67214478
34	catecholamine transport (GO:0051937)	4.56174269
35	response to water (GO:0009415)	4.55611375
36	maternal behavior (GO:0042711)	4.53307102
37	arginine catabolic process (GO:0006527)	4.51594099
38	cartilage morphogenesis (GO:0060536)	4.49765612
39	NIK/NF-kappaB signaling (GO:0038061)	4.47746523
40	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	4.47140382
41	negative regulation of calcium ion transport into cytosol (GO:0010523)	4.42555832
42	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	4.38896791
43	exogenous drug catabolic process (GO:0042738)	4.34720438
44	response to pain (GO:0048265)	4.31961249
45	suckling behavior (GO:0001967)	4.31837554
46	alkaloid metabolic process (GO:0009820)	4.24441235
47	negative regulation of neurotransmitter transport (GO:0051589)	4.23393588
48	neuromuscular synaptic transmission (GO:0007274)	4.21518967
49	neural crest cell migration (GO:0001755)	4.20000478
50	body morphogenesis (GO:0010171)	4.14296004
51	mesenchyme morphogenesis (GO:0072132)	4.06701198
52	catechol-containing compound metabolic process (GO:0009712)	4.06565186
53	catecholamine metabolic process (GO:0006584)	4.06565186
54	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.99333864
55	negative regulation of microtubule polymerization (GO:0031115)	3.97349543
56	regulation of skeletal muscle contraction (GO:0014819)	3.94566268
57	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	3.86522026
58	negative regulation of cell cycle arrest (GO:0071157)	3.84560191
59	vitamin catabolic process (GO:0009111)	3.83635358
60	fat-soluble vitamin catabolic process (GO:0042363)	3.83635358
61	parental behavior (GO:0060746)	3.81903873
62	adult heart development (GO:0007512)	3.77278632
63	peptidyl-cysteine modification (GO:0018198)	3.72468775
64	cellular response to nicotine (GO:0071316)	3.68567019
65	DNA strand renaturation (GO:0000733)	3.68255601
66	neural crest cell development (GO:0014032)	3.67457902
67	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	3.65128336
68	phenol-containing compound biosynthetic process (GO:0046189)	3.63223205
69	apoptotic process involved in morphogenesis (GO:0060561)	3.60123175
70	innervation (GO:0060384)	3.56402762
71	regulation of respiratory system process (GO:0044065)	3.55288248
72	positive regulation of cell cycle G2/M phase transition (GO:1902751)	3.55185238
73	positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)	3.55185238
74	regulation of transcription regulatory region DNA binding (GO:2000677)	3.54647095
75	cellular response to ATP (GO:0071318)	3.54487585
76	meiotic chromosome segregation (GO:0045132)	3.54391283
77	eyelid development in camera-type eye (GO:0061029)	3.51135791
78	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.42999663
79	response to parathyroid hormone (GO:0071107)	3.41706772
80	regulation of glomerulus development (GO:0090192)	3.40422479
81	embryonic body morphogenesis (GO:0010172)	3.38922832
82	cellular response to prostaglandin stimulus (GO:0071379)	3.38489214
83	positive regulation of cell size (GO:0045793)	3.38124826
84	regulation of heart morphogenesis (GO:2000826)	3.36964464
85	regulation of neurotransmitter uptake (GO:0051580)	3.34215053
86	cellular response to nerve growth factor stimulus (GO:1990090)	3.34088068
87	response to nerve growth factor (GO:1990089)	3.34088068
88	negative regulation of muscle cell apoptotic process (GO:0010656)	3.29817033
89	mating behavior (GO:0007617)	3.27896779
90	drug catabolic process (GO:0042737)	3.25661238
91	rRNA methylation (GO:0031167)	3.24957255
92	neurotransmitter metabolic process (GO:0042133)	3.22517816
93	cellular response to catecholamine stimulus (GO:0071870)	3.21361711
94	cellular response to monoamine stimulus (GO:0071868)	3.21361711
95	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	3.21072658
96	detection of temperature stimulus involved in sensory perception (GO:0050961)	3.21072658
97	axon ensheathment in central nervous system (GO:0032291)	3.14302610
98	central nervous system myelination (GO:0022010)	3.14302610
99	neuron cell-cell adhesion (GO:0007158)	3.12692158
100	cranial nerve morphogenesis (GO:0021602)	3.07991678
101	regulation of synapse structural plasticity (GO:0051823)	3.05406450
102	positive regulation of myotube differentiation (GO:0010831)	3.04818613
103	neuron maturation (GO:0042551)	3.02995533
104	alanine transport (GO:0032328)	2.99674181
105	proline transport (GO:0015824)	2.99646354
106	negative regulation of dendrite development (GO:2000171)	2.97320417
107	skeletal muscle organ development (GO:0060538)	2.96553811
108	central nervous system neuron axonogenesis (GO:0021955)	2.95731973
109	positive regulation of catecholamine secretion (GO:0033605)	2.94845639
110	ectodermal placode formation (GO:0060788)	2.94345488
111	toxin metabolic process (GO:0009404)	2.93151558
112	rRNA modification (GO:0000154)	2.92506515
113	developmental programmed cell death (GO:0010623)	2.92301219
114	mesenchymal cell development (GO:0014031)	2.91293898
115	apoptotic process involved in development (GO:1902742)	2.90472653
116	embryonic digit morphogenesis (GO:0042733)	2.88578875
117	response to nicotine (GO:0035094)	2.86231453
118	regulation of neurotransmitter transport (GO:0051588)	2.85490128
119	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.82407458
120	axon extension involved in axon guidance (GO:0048846)	2.82407458
121	detection of temperature stimulus (GO:0016048)	2.82079710
122	auditory behavior (GO:0031223)	2.79704755
123	* regulation of respiratory gaseous exchange (GO:0043576)	2.77190241
124	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.76497527
125	positive regulation of metanephros development (GO:0072216)	2.76181733
126	cholesterol biosynthetic process (GO:0006695)	2.72722509
127	peristalsis (GO:0030432)	2.69565739
128	response to amphetamine (GO:0001975)	2.68850500
129	positive regulation of skeletal muscle tissue development (GO:0048643)	2.68631605
130	outflow tract septum morphogenesis (GO:0003148)	2.68416978
131	regulation of dendrite morphogenesis (GO:0048814)	2.67957830
132	response to catecholamine (GO:0071869)	2.67312992
133	response to monoamine (GO:0071867)	2.67312992
134	retinoic acid metabolic process (GO:0042573)	2.66951547
135	positive regulation of cAMP-mediated signaling (GO:0043950)	2.66478834
136	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.64350189
137	stem cell development (GO:0048864)	2.64141048
138	cell differentiation in hindbrain (GO:0021533)	2.62069255
139	embryonic forelimb morphogenesis (GO:0035115)	2.59891818
140	regulation of cell aging (GO:0090342)	2.58540079
141	positive regulation of DNA binding (GO:0043388)	2.57202223
142	microtubule depolymerization (GO:0007019)	2.54753059
143	cranial nerve development (GO:0021545)	2.53846433
144	multicellular organismal response to stress (GO:0033555)	2.53684205
145	urogenital system development (GO:0001655)	2.52637266
146	phenol-containing compound catabolic process (GO:0019336)	13.4752542
147	* sympathetic nervous system development (GO:0048485)	10.6953035

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.78359042
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.38302615
3	NR3C1_23031785_ChIP-Seq_PC12_Mouse	3.64800241
4	ZNF263_19887448_ChIP-Seq_K562_Human	3.30723008
5	TP63_19390658_ChIP-ChIP_HaCaT_Human	3.07244378
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.98669598
7	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.95661136
8	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.91753203
9	E2F7_22180533_ChIP-Seq_HELA_Human	2.79784347
10	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.76930217
11	WT1_19549856_ChIP-ChIP_CCG9911_Human	2.65228262
12	VDR_21846776_ChIP-Seq_THP-1_Human	2.60949197
13	* RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.50315069
14	* EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.50315069
15	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.48859996
16	* SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.46293557
17	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.45034675
18	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.42110872
19	* JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.41533948
20	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.34319263
21	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.33715185
22	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.33525621
23	LXR_22292898_ChIP-Seq_THP-1_Human	2.23398668
24	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.18917226
25	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.14114741
26	* SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.98626809
27	* MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.98601241
28	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.94420916
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93976796
30	* EZH2_27294783_Chip-Seq_ESCs_Mouse	1.92680345
31	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.89069631
32	* P68_20966046_ChIP-Seq_HELA_Human	1.86558485
33	* SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.85988075
34	* SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.83083462
35	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.82477243
36	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.80583859
37	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.80465261
38	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.79790644
39	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.78895316
40	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.75072961
41	* PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.73966971
42	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.72921681
43	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.71404075
44	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.71221051
45	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.69176955
46	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.67907462
47	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.65384262
48	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.64978759
49	* RING1B_27294783_Chip-Seq_NPCs_Mouse	1.63096914
50	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.60287762
51	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.58750735
52	* TET1_21451524_ChIP-Seq_MESCs_Mouse	1.57727572
53	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.56584629
54	MYC_22102868_ChIP-Seq_BL_Human	1.55593746
55	* RNF2_27304074_Chip-Seq_ESCs_Mouse	1.53946688
56	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.51325427
57	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.50343995
58	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.48557379
59	KDM2B_26808549_Chip-Seq_K562_Human	1.47560073
60	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.46971062
61	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.45589895
62	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.44189789
63	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.43907971
64	RACK7_27058665_Chip-Seq_MCF-7_Human	1.43704325
65	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.42520013
66	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.42520013
67	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.42520013
68	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.40852310
69	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.40026817
70	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.39788831
71	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.39455368
72	AR_21572438_ChIP-Seq_LNCaP_Human	1.37201965
73	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.36751839
74	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.36616165
75	REST_21632747_ChIP-Seq_MESCs_Mouse	1.36573651
76	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.36197559
77	E2F1_20622854_ChIP-Seq_HELA_Human	1.34020823
78	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.33018451
79	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.31747494
80	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.28837090
81	* RING1B_27294783_Chip-Seq_ESCs_Mouse	1.28409150
82	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.28025155
83	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.28007803
84	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.27439991
85	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.27071721
86	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.26512259
87	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.26464991
88	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.26093483
89	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.23787402
90	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.22410528
91	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.21908137
92	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.21695815
93	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.21331247
94	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.21128885
95	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.20336381
96	PHF8_20622854_ChIP-Seq_HELA_Human	1.19532272
97	* SMC4_20622854_ChIP-Seq_HELA_Human	1.19265037
98	MAF_26560356_Chip-Seq_TH2_Human	1.18810309
99	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.18743481
100	* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.16916572
101	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.16822336
102	CTCF_21964334_Chip-Seq_Bcells_Human	1.15625344
103	* CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.15556385
104	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.14526746
105	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.14152019
106	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.13654314
107	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.11489650
108	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.10285937
109	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.09863547
110	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.09837700
111	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.08561234
112	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.07648749
113	BCOR_27268052_Chip-Seq_Bcells_Human	1.07106044
114	KDM2B_26808549_Chip-Seq_DND41_Human	1.06638688
115	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.06359224
116	* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.05912637
117	GABP_19822575_ChIP-Seq_HepG2_Human	1.05308375
118	TAF15_26573619_Chip-Seq_HEK293_Human	1.05036689
119	CTCF_27219007_Chip-Seq_Bcells_Human	1.04663862
120	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.04509276
121	DCP1A_22483619_ChIP-Seq_HELA_Human	1.04026179
122	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.03907180
123	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.03873248
124	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03241083
125	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.02908066
126	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.02002976
127	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.01611640
128	NANOG_18347094_ChIP-ChIP_MESCs_Mouse	0.99681651
129	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.95687108
130	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.94995013
131	* SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.90678856
132	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.88513760
133	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.87802096
134	EOMES_21245162_ChIP-Seq_HESCs_Human	0.87426252
135	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.87154311
136	TTF2_22483619_ChIP-Seq_HELA_Human	0.86762189
137	RARB_27405468_Chip-Seq_BRAIN_Mouse	0.86753157
138	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.86682788
139	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.86673816
140	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.86200468
141	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.84312767
142	XRN2_22483619_ChIP-Seq_HELA_Human	0.83786252
143	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.83567975
144	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.83410119
145	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.83385434
146	GBX2_23144817_ChIP-Seq_PC3_Human	0.82554076
147	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.81230285
148	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.80535833
149	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.78943767
150	* PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human	0.78541938
151	* SA1_27219007_Chip-Seq_ERYTHROID_Human	0.78410465
152	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.76081922
153	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.75672211
154	CREB1_26743006_Chip-Seq_LNCaP_Human	0.75633824
155	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.75133199
156	FUS_26573619_Chip-Seq_HEK293_Human	0.75074109

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	9.30385266
2	MP0002638_abnormal_pupillary_reflex	6.47340016
3	MP0010386_abnormal_urinary_bladder	4.86384835
4	MP0002009_preneoplasia	4.35386339
5	MP0005171_absent_coat_pigmentation	3.17151514
6	MP0001529_abnormal_vocalization	3.09320029
7	MP0004858_abnormal_nervous_system	3.05996181
8	MP0000538_abnormal_urinary_bladder	3.01280627
9	* MP0002751_abnormal_autonomic_nervous	2.96671722
10	MP0001905_abnormal_dopamine_level	2.69486673
11	MP0003136_yellow_coat_color	2.65716342
12	MP0002653_abnormal_ependyma_morphology	2.57464520
13	MP0003123_paternal_imprinting	2.52394363
14	MP0001440_abnormal_grooming_behavior	2.42941228
15	MP0001986_abnormal_taste_sensitivity	2.35846726
16	MP0009379_abnormal_foot_pigmentation	2.32435162
17	MP0003787_abnormal_imprinting	2.25384643
18	MP0003122_maternal_imprinting	2.08644007
19	MP0002127_abnormal_cardiovascular_syste	2.04828716
20	MP0005174_abnormal_tail_pigmentation	2.04093996
21	MP0005197_abnormal_uvea_morphology	2.03105091
22	MP0001188_hyperpigmentation	2.02609650
23	MP0005645_abnormal_hypothalamus_physiol	2.01978988
24	MP0004270_analgesia	1.97098855
25	MP0008872_abnormal_physiological_respon	1.96305183
26	MP0003567_abnormal_fetal_cardiomyocyte	1.89470459
27	MP0006276_abnormal_autonomic_nervous	1.72825891
28	MP0001968_abnormal_touch/_nociception	1.63901324
29	MP0009745_abnormal_behavioral_response	1.62247046
30	MP0002734_abnormal_mechanical_nocicepti	1.59785569
31	MP0001970_abnormal_pain_threshold	1.58779139
32	MP0003942_abnormal_urinary_system	1.57762659
33	MP0008877_abnormal_DNA_methylation	1.57445559
34	MP0002733_abnormal_thermal_nociception	1.51654718
35	MP0006138_congestive_heart_failure	1.42137686
36	MP0005187_abnormal_penis_morphology	1.41966221
37	MP0000372_irregular_coat_pigmentation	1.40953219
38	MP0000778_abnormal_nervous_system	1.38676270
39	MP0003868_abnormal_feces_composition	1.36359555
40	MP0000049_abnormal_middle_ear	1.26762682
41	MP0001270_distended_abdomen	1.23461441
42	MP0000955_abnormal_spinal_cord	1.20886298
43	MP0002184_abnormal_innervation	1.19477133
44	MP0003635_abnormal_synaptic_transmissio	1.18727485
45	MP0003937_abnormal_limbs/digits/tail_de	1.15343013
46	MP0000534_abnormal_ureter_morphology	1.11655027
47	MP0002909_abnormal_adrenal_gland	1.11652997
48	MP0005386_behavior/neurological_phenoty	1.10605545
49	MP0004924_abnormal_behavior	1.10605545
50	MP0003077_abnormal_cell_cycle	1.10301428
51	MP0003646_muscle_fatigue	1.09551759
52	MP0005083_abnormal_biliary_tract	1.08709395
53	MP0003111_abnormal_nucleus_morphology	1.08303111
54	MP0005646_abnormal_pituitary_gland	1.07319437
55	MP0003115_abnormal_respiratory_system	1.06240569
56	MP0002572_abnormal_emotion/affect_behav	1.06022749
57	MP0002064_seizures	1.05700923
58	MP0001756_abnormal_urination	1.05685991
59	MP0000762_abnormal_tongue_morphology	1.05561622
60	MP0000516_abnormal_urinary_system	1.03960092
61	MP0005367_renal/urinary_system_phenotyp	1.03960092
62	MP0006072_abnormal_retinal_apoptosis	1.03671175
63	MP0001501_abnormal_sleep_pattern	1.03604003
64	MP0005623_abnormal_meninges_morphology	1.02201323
65	MP0004233_abnormal_muscle_weight	1.02099049
66	MP0003279_aneurysm	0.98981915
67	MP0004043_abnormal_pH_regulation	0.98296827
68	MP0002272_abnormal_nervous_system	0.98103456
69	MP0000003_abnormal_adipose_tissue	0.97900868
70	MP0003631_nervous_system_phenotype	0.91994343
71	MP0008569_lethality_at_weaning	0.90547259
72	MP0001661_extended_life_span	0.89196600
73	MP0004883_abnormal_blood_vessel	0.88090525
74	MP0003633_abnormal_nervous_system	0.86698629
75	MP0003705_abnormal_hypodermis_morpholog	0.85918142
76	MP0000681_abnormal_thyroid_gland	0.84199776
77	MP0004130_abnormal_muscle_cell	0.84112763
78	MP0005423_abnormal_somatic_nervous	0.82470701
79	MP0005408_hypopigmentation	0.82325436
80	MP0010094_abnormal_chromosome_stability	0.81762680
81	MP0001340_abnormal_eyelid_morphology	0.78680455
82	MP0003632_abnormal_nervous_system	0.77836844
83	MP0000639_abnormal_adrenal_gland	0.77808253
84	MP0004084_abnormal_cardiac_muscle	0.77634390
85	MP0002882_abnormal_neuron_morphology	0.77548592
86	MP0009053_abnormal_anal_canal	0.77342219
87	MP0010030_abnormal_orbit_morphology	0.77008103
88	MP0002163_abnormal_gland_morphology	0.76270192
89	MP0003638_abnormal_response/metabolism_	0.74973336
90	MP0002697_abnormal_eye_size	0.74890654
91	MP0008932_abnormal_embryonic_tissue	0.74721525
92	MP0002160_abnormal_reproductive_system	0.74342182
93	MP0004811_abnormal_neuron_physiology	0.73569765
94	MP0003121_genomic_imprinting	0.73322507
95	* MP0002752_abnormal_somatic_nervous	0.71832574
96	MP0002109_abnormal_limb_morphology	0.70867666
97	MP0002063_abnormal_learning/memory/cond	0.70846687
98	MP0002106_abnormal_muscle_physiology	0.70572411
99	MP0002736_abnormal_nociception_after	0.70230315
100	MP0002932_abnormal_joint_morphology	0.70117117
101	MP0001348_abnormal_lacrimal_gland	0.69147472
102	MP0003935_abnormal_craniofacial_develop	0.68811041
103	MP0003693_abnormal_embryo_hatching	0.68626156
104	MP0003959_abnormal_lean_body	0.68610964
105	MP0008770_decreased_survivor_rate	0.68378649
106	MP0008874_decreased_physiological_sensi	0.68111145
107	MP0000477_abnormal_intestine_morphology	0.67655446
108	MP0000467_abnormal_esophagus_morphology	0.67228085
109	MP0000613_abnormal_salivary_gland	0.66121679
110	MP0000920_abnormal_myelination	0.65879149
111	MP0004381_abnormal_hair_follicle	0.65441104
112	MP0002735_abnormal_chemical_nociception	0.65070908
113	MP0004085_abnormal_heartbeat	0.64281050
114	MP0002557_abnormal_social/conspecific_i	0.64009127
115	MP0001502_abnormal_circadian_rhythm	0.63495715
116	MP0008961_abnormal_basal_metabolism	0.63481332
117	MP0004272_abnormal_basement_membrane	0.63373468
118	MP0001664_abnormal_digestion	0.62973114
119	* MP0002152_abnormal_brain_morphology	0.62790074
120	MP0004133_heterotaxia	0.61775347
121	MP0002085_abnormal_embryonic_tissue	0.61652452
122	MP0002084_abnormal_developmental_patter	0.60761850
123	MP0000747_muscle_weakness	0.60736008
124	MP0004742_abnormal_vestibular_system	0.60135761
125	MP0003861_abnormal_nervous_system	0.60018288
126	MP0002166_altered_tumor_susceptibility	0.58483246
127	MP0000751_myopathy	0.58464954
128	MP0002069_abnormal_eating/drinking_beha	0.58260395
129	MP0005253_abnormal_eye_physiology	0.57158222
130	MP0005503_abnormal_tendon_morphology	0.57118047
131	MP0000759_abnormal_skeletal_muscle	0.56811962
132	MP0000249_abnormal_blood_vessel	0.56382204
133	MP0005375_adipose_tissue_phenotype	0.56199527
134	MP0002102_abnormal_ear_morphology	0.55617732
135	* MP0002066_abnormal_motor_capabilities/c	0.55199788
136	MP0004036_abnormal_muscle_relaxation	0.53925781
137	* MP0010770_preweaning_lethality	0.53763631
138	* MP0002082_postnatal_lethality	0.53763631
139	MP0000750_abnormal_muscle_regeneration	0.52457520
140	MP0005369_muscle_phenotype	0.52381903
141	MP0000428_abnormal_craniofacial_morphol	0.52364332
142	MP0005409_darkened_coat_color	0.51459424
143	* MP0010768_mortality/aging	0.49557099
144	MP0008775_abnormal_heart_ventricle	0.49280647
145	MP0005391_vision/eye_phenotype	0.48771726
146	MP0003755_abnormal_palate_morphology	0.47918485
147	MP0001324_abnormal_eye_pigmentation	0.47759077
148	MP0005076_abnormal_cell_differentiation	0.47684840
149	MP0000427_abnormal_hair_cycle	0.47554895
150	MP0002067_abnormal_sensory_capabilities	0.46966719
151	* MP0010769_abnormal_survival	0.46520769

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Orthostatic hypotension (HP:0001278)	8.06215963
2	Annular pancreas (HP:0001734)	7.52510796
3	Neonatal hypoglycemia (HP:0001998)	6.28441979
4	Abnormal autonomic nervous system physiology (HP:0012332)	6.21310676
5	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	5.58263658
6	Abnormality of the phalanges of the 2nd finger (HP:0009541)	5.32690395
7	Hyperthyroidism (HP:0000836)	5.32546178
8	Turricephaly (HP:0000262)	4.99163279
9	Pheochromocytoma (HP:0002666)	4.71254782
10	Hypoventilation (HP:0002791)	4.69749016
11	Abnormality of calcium-phosphate metabolism (HP:0100530)	4.66891429
12	Hypercortisolism (HP:0001578)	4.52983701
13	Agitation (HP:0000713)	4.38690176
14	Esophageal atresia (HP:0002032)	4.36591731
15	Myokymia (HP:0002411)	4.32410522
16	Menstrual irregularities (HP:0000858)	4.23858633
17	Asymmetry of the thorax (HP:0001555)	4.10425589
18	Rib fusion (HP:0000902)	4.04145490
19	Neuroendocrine neoplasm (HP:0100634)	4.01470015
20	Depressed nasal tip (HP:0000437)	3.94111950
21	Enlarged penis (HP:0000040)	3.91219608
22	Limb dystonia (HP:0002451)	3.80315105
23	Hyperparathyroidism (HP:0000843)	3.78683536
24	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	3.74998934
25	Intestinal atresia (HP:0011100)	3.65661723
26	Patellar aplasia (HP:0006443)	3.53130234
27	Potter facies (HP:0002009)	3.52647674
28	Facial shape deformation (HP:0011334)	3.52647674
29	Hypotension (HP:0002615)	3.45849985
30	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	3.40017620
31	Abnormality of the 2nd finger (HP:0004100)	3.35497043
32	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	3.33546093
33	Coronal craniosynostosis (HP:0004440)	3.31212795
34	Bony spicule pigmentary retinopathy (HP:0007737)	3.29848655
35	Attenuation of retinal blood vessels (HP:0007843)	3.28882038
36	Aplasia/Hypoplasia of the patella (HP:0006498)	3.25075440
37	Abnormality of the parathyroid morphology (HP:0011766)	3.13954166
38	Abnormality of the phalanges of the hallux (HP:0010057)	3.09952247
39	Neuroblastic tumors (HP:0004376)	3.06636630
40	Peripheral primitive neuroectodermal neoplasm (HP:0030067)	3.06636630
41	Neuroblastoma (HP:0003006)	3.06636630
42	Primitive neuroectodermal tumor (HP:0030065)	3.06636630
43	Abnormality of the phalanges of the 5th finger (HP:0004213)	3.06523026
44	Cerebral hemorrhage (HP:0001342)	2.97552520
45	Autoamputation (HP:0001218)	2.93802320
46	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.93036255
47	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.90389789
48	Testicular neoplasm (HP:0010788)	2.88661751
49	Breast hypoplasia (HP:0003187)	2.86352075
50	Bowel diverticulosis (HP:0005222)	2.82598432
51	Impulsivity (HP:0100710)	2.81430339
52	Growth hormone excess (HP:0000845)	2.78554486
53	Testicular atrophy (HP:0000029)	2.77781614
54	Rectal fistula (HP:0100590)	2.76423409
55	Rectovaginal fistula (HP:0000143)	2.76423409
56	Restlessness (HP:0000711)	2.73357611
57	Ulnar bowing (HP:0003031)	2.70341625
58	Postural tremor (HP:0002174)	2.65871853
59	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.65686001
60	Macroorchidism (HP:0000053)	2.65161788
61	Intestinal fistula (HP:0100819)	2.62652269
62	Supernumerary spleens (HP:0009799)	2.61804633
63	Episodic fever (HP:0001954)	2.60250716
64	Abnormality of the corticospinal tract (HP:0002492)	2.59080622
65	Thyroid carcinoma (HP:0002890)	2.58430248
66	Facial hemangioma (HP:0000329)	2.56867098
67	Aplasia of the musculature (HP:0100854)	2.55343664
68	Goiter (HP:0000853)	2.51156049
69	Occipital encephalocele (HP:0002085)	2.49026321
70	Gastrointestinal atresia (HP:0002589)	2.44894541
71	Hyperphosphatemia (HP:0002905)	2.43531712
72	Non-midline cleft lip (HP:0100335)	2.40392280
73	Myotonia (HP:0002486)	2.38659890
74	Vaginal fistula (HP:0004320)	2.38211614
75	Absent radius (HP:0003974)	2.34931446
76	Ectopic kidney (HP:0000086)	2.34733678
77	Poikiloderma (HP:0001029)	2.34450146
78	Shawl scrotum (HP:0000049)	2.33608564
79	Action tremor (HP:0002345)	2.33183636
80	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.31187160
81	Neoplasm of the thyroid gland (HP:0100031)	2.31110591
82	Anteriorly placed anus (HP:0001545)	2.30791576
83	Sensory axonal neuropathy (HP:0003390)	2.29145662
84	Failure to thrive in infancy (HP:0001531)	2.28959807
85	Adrenal overactivity (HP:0002717)	2.28778508
86	Thin bony cortex (HP:0002753)	2.26531712
87	Neoplasm of the peripheral nervous system (HP:0100007)	2.25199326
88	Disproportionate tall stature (HP:0001519)	2.22155112
89	Chorioretinal atrophy (HP:0000533)	2.20802971
90	Aplasia involving forearm bones (HP:0009822)	2.19247883
91	Absent forearm bone (HP:0003953)	2.19247883
92	Aplasia/hypoplasia of the humerus (HP:0006507)	2.11842417
93	Glossoptosis (HP:0000162)	2.11486473
94	Akinesia (HP:0002304)	2.08864750
95	Overlapping toe (HP:0001845)	2.07597645
96	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.07575274
97	Short humerus (HP:0005792)	2.07227227
98	Abnormality of the aortic arch (HP:0012303)	2.05815779
99	Abnormality of glycolysis (HP:0004366)	2.04467701
100	Increased serum pyruvate (HP:0003542)	2.04467701
101	Fetal akinesia sequence (HP:0001989)	2.03827206
102	Arthropathy (HP:0003040)	2.02135729
103	Hypothermia (HP:0002045)	11.7649414
104	Popliteal pterygium (HP:0009756)	1.98788717
105	Intestinal polyposis (HP:0200008)	1.95131040
106	Asplenia (HP:0001746)	1.93271022
107	Dyschromatopsia (HP:0007641)	1.92831678
108	Abnormal gallbladder physiology (HP:0012438)	1.91511859
109	Cholecystitis (HP:0001082)	1.91511859
110	Abnormality of the 4th metacarpal (HP:0010012)	1.90525085
111	Congenital stationary night blindness (HP:0007642)	1.89980877
112	Hypoplasia of the radius (HP:0002984)	1.89951566
113	Hypoplastic nipples (HP:0002557)	1.89632926
114	Short palpebral fissure (HP:0012745)	1.89444078
115	Sex reversal (HP:0012245)	1.89387585
116	Abnormal sex determination (HP:0012244)	1.89387585
117	Delayed epiphyseal ossification (HP:0002663)	1.87485384
118	Metaphyseal dysplasia (HP:0100255)	1.86499413
119	Aplastic anemia (HP:0001915)	1.85466964
120	Bilateral microphthalmos (HP:0007633)	1.84880164
121	Anomalous pulmonary venous return (HP:0010772)	1.84383836
122	Abnormality of the vocal cords (HP:0008777)	1.84266716
123	Nasal speech (HP:0001611)	1.83934540
124	Overfolded helix (HP:0000396)	1.82955710
125	Abnormal pupillary function (HP:0007686)	1.82358291
126	Squamous cell carcinoma (HP:0002860)	1.82326912
127	Birth length less than 3rd percentile (HP:0003561)	1.81934390
128	Neonatal onset (HP:0003623)	1.81205656
129	Oligodactyly (HP:0012165)	1.80984213
130	Intestinal polyp (HP:0005266)	1.80146929
131	Genital tract atresia (HP:0001827)	1.79375350
132	Abnormal hemoglobin (HP:0011902)	1.78749127
133	Increased hepatocellular lipid droplets (HP:0006565)	1.77443873
134	Striae distensae (HP:0001065)	1.77149403
135	Recurrent corneal erosions (HP:0000495)	1.76847906
136	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.76088997
137	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.76088997
138	Stenosis of the external auditory canal (HP:0000402)	1.75807438
139	Hypoplastic pelvis (HP:0008839)	1.74978997
140	Humeroradial synostosis (HP:0003041)	1.74234880
141	Synostosis involving the elbow (HP:0003938)	1.74234880
142	Renal dysplasia (HP:0000110)	1.71658230
143	Parakeratosis (HP:0001036)	1.70927107
144	Nervous tissue neoplasm (HP:0030060)	1.70676252
145	Neuroectodermal neoplasm (HP:0030061)	1.70676252
146	Neuroepithelial neoplasm (HP:0030063)	1.70676252
147	Partial duplication of the phalanx of hand (HP:0009999)	1.70180481
148	Bicornuate uterus (HP:0000813)	1.69295531
149	Absent thumb (HP:0009777)	1.67741755
150	Retinal dysplasia (HP:0007973)	1.67689723
151	Neurofibrillary tangles (HP:0002185)	1.66709360
152	Microglossia (HP:0000171)	1.65834881
153	Insidious onset (HP:0003587)	1.65796790
154	Termporal pattern (HP:0011008)	1.65796790
155	Abnormally folded helix (HP:0008544)	1.64268368
156	Malignant neoplasm of the central nervous system (HP:0100836)	1.62344523
157	Partial agenesis of the corpus callosum (HP:0001338)	1.62249411
158	Morphological abnormality of the pyramidal tract (HP:0002062)	1.61242781
159	Truncus arteriosus (HP:0001660)	1.60389271
160	Anxiety (HP:0000739)	1.60181482
161	Cerebral inclusion bodies (HP:0100314)	1.59123684
162	Choreoathetosis (HP:0001266)	1.58612636
163	Emotional lability (HP:0000712)	1.56563089
164	Abnormality of the pulmonary veins (HP:0011718)	1.56538979
165	Axonal loss (HP:0003447)	1.54587049
166	Dry hair (HP:0011359)	1.54148515
167	Cerebral hypomyelination (HP:0006808)	1.52836149
168	Nasolacrimal duct obstruction (HP:0000579)	1.50794616
169	Exertional dyspnea (HP:0002875)	1.50783945
170	Mitochondrial inheritance (HP:0001427)	1.50205762
171	Renal Fanconi syndrome (HP:0001994)	1.49820776
172	Lipid accumulation in hepatocytes (HP:0006561)	1.49773978

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NTRK1	7.23521568
2	GRK7	4.46024183
3	MAPK15	3.69788323
4	MAP3K10	3.58534586
5	AKT3	2.86436468
6	MAPKAPK5	2.79852250
7	PNCK	2.64371451
8	STK39	2.60800584
9	MATK	2.59771420
10	INSRR	2.54198732
11	MET	2.50405428
12	GRK5	2.39113413
13	LIMK1	2.36816724
14	CSNK1G3	2.34090160
15	BUB1	2.30749575
16	PTK2	2.10345921
17	UHMK1	2.06427323
18	FLT3	2.05670773
19	ICK	1.86997937
20	CSNK1G2	1.85159625
21	BMPR1B	1.77787083
22	CSNK1G1	1.65137107
23	ADRBK1	1.62208925
24	SRPK1	1.58650778
25	DYRK1B	1.55916316
26	MUSK	1.54246698
27	ZAK	1.52766510
28	TAF1	1.39258112
29	CDK4	1.30606904
30	ERBB2	1.29640425
31	MAP2K1	1.28824273
32	MAP2K2	1.26588027
33	SCYL2	1.26319052
34	WNK4	1.23913170
35	RET	1.20157130
36	DYRK2	1.19193860
37	BLK	1.14657965
38	CSNK1A1L	1.13408269
39	CHEK2	1.12762159
40	FGFR2	1.11358903
41	EEF2K	1.10800054
42	WNK1	1.09854878
43	CDC7	1.09228563
44	NTRK3	1.07213708
45	TESK2	1.03610771
46	CCNB1	1.03530833
47	MAP3K4	1.01969828
48	NME1	1.01638118
49	CAMKK2	1.01147188
50	PRKD3	0.99977916
51	NME2	0.98931027
52	PDGFRB	0.98930703
53	PDGFRA	0.97699185
54	TYRO3	0.97290878
55	SMG1	0.96708060
56	MKNK2	0.96170484
57	TSSK6	0.94364250
58	BCR	0.93872652
59	MTOR	0.92489889
60	TRIB3	0.92211150
61	ALK	0.91257127
62	DAPK2	0.90790817
63	OXSR1	0.90431018
64	PKN1	0.89924772
65	ATR	0.89760011
66	FGR	0.88777099
67	TLK1	0.88192671
68	EPHB2	0.88111363
69	STK16	0.87747217
70	MAP3K2	0.87305809
71	CAMKK1	0.83774131
72	CDK6	0.81990415
73	MAP2K3	0.80262470
74	ADRBK2	0.79764279
75	EIF2AK1	0.77625146
76	SIK1	0.76854261
77	PHKG2	0.76726068
78	PHKG1	0.76726068
79	CAMK1	0.76242888
80	PRKCE	0.72782170
81	CDK19	0.72231084
82	IRAK2	0.72201951
83	NEK2	0.72026450
84	RPS6KA2	0.70940703
85	ROCK2	0.70313117
86	DYRK3	0.69540844
87	DAPK3	0.69274587
88	PKN2	0.68982572
89	CAMK4	0.68625918
90	MKNK1	0.68283737
91	TESK1	0.67324109
92	MINK1	0.64992296
93	CSNK1E	0.63655752
94	RPS6KL1	0.62407166
95	RPS6KC1	0.62407166
96	GSK3A	0.59440738
97	LATS2	0.59335799
98	NTRK2	0.58754761
99	PAK3	0.57805169
100	CAMK2B	0.57804144
101	KSR2	0.56809729
102	MAPK11	0.56186049
103	TGFBR1	0.53267977
104	PLK4	0.52763693
105	RPS6KA6	0.52482085
106	PASK	0.51776617
107	HCK	0.48792287
108	CDK2	0.48650552
109	DDR2	0.48493140
110	CDK14	0.48066310
111	AKT1	0.47955052
112	ROCK1	0.46862070
113	CAMK1G	0.46751553
114	PBK	0.46740548
115	AKT2	0.46147378
116	CAMK2A	0.44497096
117	LRRK2	0.44073396
118	ILK	0.43778893
119	CDK8	0.43438947
120	CAMK2D	0.42651875
121	CDK11A	0.42584516
122	SIK2	0.42551840
123	CSNK1D	0.42462808
124	MELK	0.42196281
125	IGF1R	0.42030754
126	TTK	0.41672590
127	MAP2K4	0.41455064
128	PLK1	0.41441717
129	CDK15	0.41119169
130	CAMK2G	0.40330888
131	STK11	0.40031349
132	MAP3K9	0.38875065
133	LMTK2	0.38153783
134	SGK223	0.38024304
135	SGK494	0.38024304
136	AURKA	0.37220184
137	CDK18	0.36605835
138	CDK3	0.36321442
139	CDK1	0.36188975
140	INSR	0.35542159
141	BRD4	0.35357126
142	MAPK8	0.35188173
143	RPS6KA5	0.34475822
144	MAPK14	0.34090642
145	PAK6	0.33890421
146	ZAP70	0.33327033
147	CDC42BPA	0.33281591
148	BRSK1	0.33193802
149	TRPM7	0.33042833
150	CDK7	0.32554899
151	MARK1	0.30753827
152	VRK1	0.28675792

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	4.95942941
2	Tyrosine metabolism_Homo sapiens_hsa00350	4.33139356
3	Sulfur relay system_Homo sapiens_hsa04122	4.18963805
4	Phenylalanine metabolism_Homo sapiens_hsa00360	3.50193549
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.23731869
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.22425696
7	Oxidative phosphorylation_Homo sapiens_hsa00190	3.06472969
8	Cocaine addiction_Homo sapiens_hsa05030	3.00289569
9	Parkinsons disease_Homo sapiens_hsa05012	2.91588390
10	Steroid biosynthesis_Homo sapiens_hsa00100	2.64143494
11	Non-small cell lung cancer_Homo sapiens_hsa05223	2.57118675
12	Histidine metabolism_Homo sapiens_hsa00340	2.55314680
13	Arginine and proline metabolism_Homo sapiens_hsa00330	2.47456760
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.38478184
15	Long-term depression_Homo sapiens_hsa04730	2.36463451
16	Cholinergic synapse_Homo sapiens_hsa04725	2.20814623
17	Alzheimers disease_Homo sapiens_hsa05010	2.18857184
18	Serotonergic synapse_Homo sapiens_hsa04726	2.17055854
19	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.14992288
20	Ribosome_Homo sapiens_hsa03010	2.05909908
21	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.99717286
22	Amphetamine addiction_Homo sapiens_hsa05031	1.90194959
23	Dopaminergic synapse_Homo sapiens_hsa04728	1.86513529
24	Nicotine addiction_Homo sapiens_hsa05033	1.75503910
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.75090609
26	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.69380079
27	Cell cycle_Homo sapiens_hsa04110	1.66975248
28	Huntingtons disease_Homo sapiens_hsa05016	1.64408416
29	Renin secretion_Homo sapiens_hsa04924	1.61483137
30	Vibrio cholerae infection_Homo sapiens_hsa05110	1.60555938
31	DNA replication_Homo sapiens_hsa03030	1.60349867
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.54785007
33	Arginine biosynthesis_Homo sapiens_hsa00220	1.53547521
34	Base excision repair_Homo sapiens_hsa03410	1.53534309
35	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.50681970
36	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.50516813
37	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.48057730
38	Lysine degradation_Homo sapiens_hsa00310	1.46741566
39	Salivary secretion_Homo sapiens_hsa04970	1.41558325
40	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.36471331
41	Bile secretion_Homo sapiens_hsa04976	1.35999417
42	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.34622215
43	Gap junction_Homo sapiens_hsa04540	1.33687319
44	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.32988536
45	Circadian entrainment_Homo sapiens_hsa04713	1.31229599
46	Cardiac muscle contraction_Homo sapiens_hsa04260	1.29179071
47	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.20706407
48	Pyrimidine metabolism_Homo sapiens_hsa00240	1.19897760
49	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.18807751
50	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.17998789
51	Thyroid cancer_Homo sapiens_hsa05216	1.14660924
52	Folate biosynthesis_Homo sapiens_hsa00790	1.14568149
53	Non-homologous end-joining_Homo sapiens_hsa03450	1.13744351
54	Pancreatic secretion_Homo sapiens_hsa04972	1.12005520
55	Spliceosome_Homo sapiens_hsa03040	1.11395220
56	Alcoholism_Homo sapiens_hsa05034	1.10505578
57	Proteasome_Homo sapiens_hsa03050	1.10149795
58	Homologous recombination_Homo sapiens_hsa03440	1.09453857
59	GnRH signaling pathway_Homo sapiens_hsa04912	1.09183169
60	RNA transport_Homo sapiens_hsa03013	1.09109084
61	Tryptophan metabolism_Homo sapiens_hsa00380	1.08851144
62	One carbon pool by folate_Homo sapiens_hsa00670	1.08657947
63	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.08325300
64	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.07468665
65	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.06690585
66	Collecting duct acid secretion_Homo sapiens_hsa04966	1.03816881
67	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.03816492
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.00498133
69	Estrogen signaling pathway_Homo sapiens_hsa04915	0.99697533
70	Axon guidance_Homo sapiens_hsa04360	0.99287472
71	Insulin secretion_Homo sapiens_hsa04911	0.96477944
72	Basal transcription factors_Homo sapiens_hsa03022	0.95218991
73	Basal cell carcinoma_Homo sapiens_hsa05217	0.95212650
74	Gastric acid secretion_Homo sapiens_hsa04971	0.94484072
75	mRNA surveillance pathway_Homo sapiens_hsa03015	0.93540529
76	Fatty acid elongation_Homo sapiens_hsa00062	0.93467928
77	Sphingolipid metabolism_Homo sapiens_hsa00600	0.90564701
78	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.89703640
79	Ether lipid metabolism_Homo sapiens_hsa00565	0.88741788
80	Glioma_Homo sapiens_hsa05214	0.87217670
81	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.87033684
82	Glutamatergic synapse_Homo sapiens_hsa04724	0.85946055
83	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.84933197
84	Melanogenesis_Homo sapiens_hsa04916	0.84099235
85	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.82103810
86	MicroRNAs in cancer_Homo sapiens_hsa05206	0.80475392
87	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.79456925
88	Linoleic acid metabolism_Homo sapiens_hsa00591	0.77267250
89	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.76323800
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.74046424
91	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.72468024
92	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.72317198
93	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72279460
94	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.72122559
95	Colorectal cancer_Homo sapiens_hsa05210	0.71380766
96	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.68411985
97	Mismatch repair_Homo sapiens_hsa03430	0.67987382
98	mTOR signaling pathway_Homo sapiens_hsa04150	0.66940877
99	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.65996007
100	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.65716498
101	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.64216935
102	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.63259161
103	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.60870706
104	Selenocompound metabolism_Homo sapiens_hsa00450	0.59785144
105	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59448211
106	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.57737556
107	Nucleotide excision repair_Homo sapiens_hsa03420	0.57015323
108	Platelet activation_Homo sapiens_hsa04611	0.55886778
109	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55523147
110	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.55093804
111	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53541828
112	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.53312773
113	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.53124683
114	Renal cell carcinoma_Homo sapiens_hsa05211	0.52461787
115	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.49019682
116	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.47981271
117	Type II diabetes mellitus_Homo sapiens_hsa04930	0.47450663
118	Phagosome_Homo sapiens_hsa04145	0.46977669
119	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46911480
120	Purine metabolism_Homo sapiens_hsa00230	0.45670232
121	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.44662710
122	Morphine addiction_Homo sapiens_hsa05032	0.44211828
123	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.43438554
124	RNA polymerase_Homo sapiens_hsa03020	0.43054446
125	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.42379648
126	ErbB signaling pathway_Homo sapiens_hsa04012	0.42245249
127	Bladder cancer_Homo sapiens_hsa05219	0.42157651
128	Melanoma_Homo sapiens_hsa05218	0.42113461
129	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.41768187
130	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.41756450
131	cAMP signaling pathway_Homo sapiens_hsa04024	0.38957021
132	Choline metabolism in cancer_Homo sapiens_hsa05231	0.38051082
133	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37271444
134	Pathways in cancer_Homo sapiens_hsa05200	0.37224627
135	Wnt signaling pathway_Homo sapiens_hsa04310	0.37106222
136	AMPK signaling pathway_Homo sapiens_hsa04152	0.36977018
137	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.36661546
138	Prion diseases_Homo sapiens_hsa05020	0.36030633
139	Rap1 signaling pathway_Homo sapiens_hsa04015	0.34267847
140	VEGF signaling pathway_Homo sapiens_hsa04370	0.33873387
141	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.33862059
142	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.33586089
143	Endometrial cancer_Homo sapiens_hsa05213	0.33551067
144	Phototransduction_Homo sapiens_hsa04744	0.32976261
145	Prolactin signaling pathway_Homo sapiens_hsa04917	0.32902312
146	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.32423836
147	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.31249852
148	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31215947
149	Taste transduction_Homo sapiens_hsa04742	0.30731987
150	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.30237097
151	Calcium signaling pathway_Homo sapiens_hsa04020	0.29419238
152	Sulfur metabolism_Homo sapiens_hsa00920	0.29210498
153	Notch signaling pathway_Homo sapiens_hsa04330	0.28617647
154	Ras signaling pathway_Homo sapiens_hsa04014	0.27599507
155	Metabolic pathways_Homo sapiens_hsa01100	0.25866097
156	Pyruvate metabolism_Homo sapiens_hsa00620	0.24516306
157	African trypanosomiasis_Homo sapiens_hsa05143	0.24321382
158	Olfactory transduction_Homo sapiens_hsa04740	0.23983340
159	Tight junction_Homo sapiens_hsa04530	0.23845562
160	Glucagon signaling pathway_Homo sapiens_hsa04922	0.21875368
161	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.21830053
162	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.21132754
163	GABAergic synapse_Homo sapiens_hsa04727	0.19986568
164	Insulin signaling pathway_Homo sapiens_hsa04910	0.18730171
165	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.17461646

PHOX2A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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