PHOX2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of dendrite morphogenesis (GO:0050774)8.37696037
2regulation of cardioblast proliferation (GO:0003264)8.00853974
3regulation of secondary heart field cardioblast proliferation (GO:0003266)8.00853974
4negative regulation of cardiac muscle cell apoptotic process (GO:0010667)7.48989420
5synaptic transmission, cholinergic (GO:0007271)7.11080609
6coronary vasculature morphogenesis (GO:0060977)7.07077153
7neurotransmitter catabolic process (GO:0042135)6.82784293
8endocardial cushion morphogenesis (GO:0003203)6.32967601
9norepinephrine metabolic process (GO:0042415)6.26859613
10catecholamine biosynthetic process (GO:0042423)6.21783420
11catechol-containing compound biosynthetic process (GO:0009713)6.21783420
12negative regulation of striated muscle cell apoptotic process (GO:0010664)5.96079929
13behavioral response to ethanol (GO:0048149)5.92502528
14positive regulation of transcription regulatory region DNA binding (GO:2000679)5.84714205
15dopamine metabolic process (GO:0042417)5.77695620
16cell migration involved in heart development (GO:0060973)5.47850157
17neurotransmitter biosynthetic process (GO:0042136)5.25147754
18cardiac ventricle formation (GO:0003211)5.03652871
19mesenchyme morphogenesis (GO:0072132)4.99119707
20negative regulation of microtubule polymerization (GO:0031115)4.97745323
21dopamine biosynthetic process (GO:0042416)4.97279608
22cardiac chamber formation (GO:0003207)4.95701420
23regulation of cardiac muscle cell apoptotic process (GO:0010665)4.88188600
24catecholamine transport (GO:0051937)4.80428724
25neuromuscular synaptic transmission (GO:0007274)4.79438732
26negative regulation of dendrite development (GO:2000171)4.75055008
27cellular response to prostaglandin stimulus (GO:0071379)4.74489042
28response to parathyroid hormone (GO:0071107)4.74332720
29body morphogenesis (GO:0010171)4.74210931
30neurofilament cytoskeleton organization (GO:0060052)4.63265565
31tongue development (GO:0043586)4.57053720
32* dopaminergic neuron differentiation (GO:0071542)4.51488560
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.51156383
34alkaloid metabolic process (GO:0009820)4.48922754
35pyrimidine nucleobase catabolic process (GO:0006208)4.47104543
36catecholamine metabolic process (GO:0006584)4.41396043
37catechol-containing compound metabolic process (GO:0009712)4.41396043
38response to water (GO:0009415)4.41006641
39regulation of striated muscle cell apoptotic process (GO:0010662)4.39033670
40activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.33338753
41cartilage morphogenesis (GO:0060536)4.32430482
42maternal behavior (GO:0042711)4.27976198
43positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.21328060
44arginine catabolic process (GO:0006527)4.11865053
45peripheral nervous system neuron development (GO:0048935)4.10153718
46axon extension involved in axon guidance (GO:0048846)4.09002326
47neuron projection extension involved in neuron projection guidance (GO:1902284)4.09002326
48adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.03919375
49* enteric nervous system development (GO:0048484)4.00599116
50regulation of cell proliferation involved in heart morphogenesis (GO:2000136)4.00544166
51response to pain (GO:0048265)3.91345820
52suckling behavior (GO:0001967)3.90683473
53mating behavior (GO:0007617)3.88140271
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.80632820
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.80632820
56mesenchymal cell proliferation (GO:0010463)3.79159323
57negative regulation of calcium ion transport into cytosol (GO:0010523)3.76596428
58negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.73357583
59exogenous drug catabolic process (GO:0042738)3.72601751
60response to amphetamine (GO:0001975)3.68416251
61regulation of NFAT protein import into nucleus (GO:0051532)3.66311967
62cellular response to nicotine (GO:0071316)3.64467512
63parental behavior (GO:0060746)3.63296672
64neurotransmitter metabolic process (GO:0042133)3.57297440
65proline transport (GO:0015824)3.55614825
66phenol-containing compound biosynthetic process (GO:0046189)3.54507144
67response to prostaglandin E (GO:0034695)3.49577346
68* regulation of respiratory gaseous exchange (GO:0043576)3.44806347
69positive regulation of cellular response to oxidative stress (GO:1900409)3.44745124
70positive regulation of response to oxidative stress (GO:1902884)3.44745124
71negative regulation of DNA repair (GO:0045738)3.42306655
72auditory receptor cell stereocilium organization (GO:0060088)3.40295073
73adult heart development (GO:0007512)3.34105736
74nucleobase catabolic process (GO:0046113)3.28964732
75regulation of dendrite morphogenesis (GO:0048814)3.28356155
76embryonic body morphogenesis (GO:0010172)3.27956832
77ectodermal placode formation (GO:0060788)3.27440347
78skeletal muscle organ development (GO:0060538)3.25012901
79regulation of transcription regulatory region DNA binding (GO:2000677)3.24092156
80toxin metabolic process (GO:0009404)3.23157686
81primary amino compound metabolic process (GO:1901160)3.22963465
82response to nerve growth factor (GO:1990089)3.20573437
83cellular response to nerve growth factor stimulus (GO:1990090)3.20573437
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.18945926
85spinal cord motor neuron differentiation (GO:0021522)3.18589828
86regulation of neurotransmitter transport (GO:0051588)3.14552983
87response to nicotine (GO:0035094)3.11025281
88negative regulation of muscle cell apoptotic process (GO:0010656)3.10733606
89neuron cell-cell adhesion (GO:0007158)3.10249220
90innervation (GO:0060384)3.09625145
91positive regulation of cAMP-mediated signaling (GO:0043950)3.09289416
92relaxation of smooth muscle (GO:0044557)3.04765992
93* neural crest cell migration (GO:0001755)3.04155994
94regulation of cell maturation (GO:1903429)3.04132362
95oxygen transport (GO:0015671)3.04100087
96neural crest cell development (GO:0014032)3.03983147
97regulation of heart morphogenesis (GO:2000826)3.03778178
98regulation of neurotransmitter uptake (GO:0051580)3.03299505
99peristalsis (GO:0030432)3.02123819
100apoptotic process involved in development (GO:1902742)2.99733183
101negative regulation of multicellular organism growth (GO:0040015)2.96612679
102dopamine receptor signaling pathway (GO:0007212)2.93930969
103outflow tract septum morphogenesis (GO:0003148)2.93813197
104positive regulation of protein depolymerization (GO:1901881)2.93488280
105regulation of short-term neuronal synaptic plasticity (GO:0048172)2.93107869
106layer formation in cerebral cortex (GO:0021819)2.91506949
107positive regulation of fatty acid beta-oxidation (GO:0032000)2.90259423
108regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.89007955
109heart morphogenesis (GO:0003007)2.88566277
110auditory behavior (GO:0031223)2.88452217
111regulation of mRNA catabolic process (GO:0061013)2.88427977
112neurotransmitter secretion (GO:0007269)2.88087901
113regulation of neurotransmitter secretion (GO:0046928)2.87305278
114positive regulation of neurotransmitter transport (GO:0051590)2.87244060
115detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.87121077
116detection of temperature stimulus involved in sensory perception (GO:0050961)2.87121077
117regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86981816
118positive regulation of DNA binding (GO:0043388)2.85430298
119negative regulation of mRNA metabolic process (GO:1903312)2.85113084
120adrenergic receptor signaling pathway (GO:0071875)2.83984095
121regulation of chemokine-mediated signaling pathway (GO:0070099)2.83268383
122drug catabolic process (GO:0042737)2.81705810
123positive regulation of RNA splicing (GO:0033120)2.79851018
124detection of temperature stimulus (GO:0016048)2.79332999
125midbrain development (GO:0030901)2.79124528
126stress granule assembly (GO:0034063)2.78854581
127negative regulation of neurotransmitter transport (GO:0051589)2.78531394
128* cell migration in hindbrain (GO:0021535)2.78141636
129regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.76648558
130regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.76648558
131apoptotic process involved in morphogenesis (GO:0060561)2.76108553
132viral transcription (GO:0019083)2.75971809
133positive regulation of cell size (GO:0045793)2.73838119
134locomotory exploration behavior (GO:0035641)2.70223113
135cranial nerve development (GO:0021545)2.70158791
136nuclear pore complex assembly (GO:0051292)2.64917831
137spliceosomal complex assembly (GO:0000245)2.60528966
138cell differentiation in spinal cord (GO:0021515)2.60424529
139embryonic camera-type eye morphogenesis (GO:0048596)2.59976633
140embryonic digit morphogenesis (GO:0042733)2.57822370
141negative chemotaxis (GO:0050919)2.57143086
142neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.55219005
143cranial nerve morphogenesis (GO:0021602)2.53016589
144central nervous system projection neuron axonogenesis (GO:0021952)2.49507268
145protein-DNA complex disassembly (GO:0032986)2.48636594
146nucleosome disassembly (GO:0006337)2.48636594
147mesenchymal cell development (GO:0014031)2.48216312
148positive regulation of glomerulus development (GO:0090193)2.46441312
149outer ear morphogenesis (GO:0042473)2.44601054
150phenol-containing compound catabolic process (GO:0019336)13.0828879
151* sympathetic nervous system development (GO:0048485)11.3488584
152behavioral response to nicotine (GO:0035095)11.2573199

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.40723301
2E2F7_22180533_ChIP-Seq_HELA_Human4.14400483
3EZH2_22144423_ChIP-Seq_EOC_Human3.89509137
4NR3C1_23031785_ChIP-Seq_PC12_Mouse3.76488633
5ZNF263_19887448_ChIP-Seq_K562_Human3.13556493
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.01460791
7* EZH2_27304074_Chip-Seq_ESCs_Mouse3.00004528
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.96987122
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.95715690
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.93522314
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.93522314
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.92381461
13* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92199512
14* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.75956158
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.69826451
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.64030106
17* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59217013
18* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58041288
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51424858
20GATA1_22025678_ChIP-Seq_K562_Human2.51294937
21* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38519691
22* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36483565
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.35745433
24* ERG_21242973_ChIP-ChIP_JURKAT_Human2.33128234
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24926050
26ZFP281_18757296_ChIP-ChIP_E14_Mouse2.24810551
27* EED_16625203_ChIP-ChIP_MESCs_Mouse2.17365830
28ESR1_15608294_ChIP-ChIP_MCF-7_Human2.17018764
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13954437
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11468335
31REST_18959480_ChIP-ChIP_MESCs_Mouse2.07651275
32* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07045016
33* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04614244
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.03204759
35* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.03140187
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02300274
37* EZH2_27294783_Chip-Seq_ESCs_Mouse1.95720274
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.93250801
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.88768810
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83404611
41REST_21632747_ChIP-Seq_MESCs_Mouse1.80092153
42* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.77374308
43* RNF2_27304074_Chip-Seq_ESCs_Mouse1.72538330
44* TP53_20018659_ChIP-ChIP_R1E_Mouse1.65319967
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62804435
46KDM2B_26808549_Chip-Seq_K562_Human1.60062193
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59337756
48* RING1B_27294783_Chip-Seq_NPCs_Mouse1.56504736
49* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.53865196
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.42736629
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.40967367
52* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40558974
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.39657749
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35245718
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32394618
56CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.31917142
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31205162
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30428307
59* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30170245
60TAF15_26573619_Chip-Seq_HEK293_Human1.29115786
61SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.24828221
62* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23536563
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23484388
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23240240
65BCAT_22108803_ChIP-Seq_LS180_Human1.22645736
66AR_21909140_ChIP-Seq_LNCAP_Human1.20792290
67* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20701910
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18956094
69HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18904492
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18678856
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17896645
72* RNF2_27304074_Chip-Seq_NSC_Mouse1.16617496
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16092408
74CLOCK_20551151_ChIP-Seq_293T_Human1.15908546
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15578112
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15042592
77RARB_27405468_Chip-Seq_BRAIN_Mouse1.14206287
78IRF1_19129219_ChIP-ChIP_H3396_Human1.12456821
79FUS_26573619_Chip-Seq_HEK293_Human1.12119780
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.10813911
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10687608
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.10533008
83CTCF_27219007_Chip-Seq_Bcells_Human1.09956524
84JUN_21703547_ChIP-Seq_K562_Human1.09274212
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08036451
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08015498
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06698095
88GBX2_23144817_ChIP-Seq_PC3_Human1.06363970
89STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.06151144
90* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03013810
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01505892
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01015125
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.99790894
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99068193
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98560362
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97613947
97TTF2_22483619_ChIP-Seq_HELA_Human0.97489546
98CREB1_26743006_Chip-Seq_LNCaP_Human0.96722657
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96023872
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95685578
101POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95469184
102SA1_27219007_Chip-Seq_ERYTHROID_Human0.95083192
103YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94108813
104MYC_18555785_ChIP-Seq_MESCs_Mouse0.93139080
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92938395
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92899243
107POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.91867975
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91386351
109* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91351043
110P300_19829295_ChIP-Seq_ESCs_Human0.90429515
111* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90391535
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88645401
113* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88041003
114ESR2_21235772_ChIP-Seq_MCF-7_Human0.87726349
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87667807
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87064546
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87017129
118FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86636017
119TCF4_18268006_ChIP-ChIP_LS174T_Human0.86243470
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86157081
121DROSHA_22980978_ChIP-Seq_HELA_Human0.85989637
122SOX9_26525672_Chip-Seq_HEART_Mouse0.85050956
123TP63_19390658_ChIP-ChIP_HaCaT_Human0.84644398
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83315344
125MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.82812451
126RUNX1_26923725_Chip-Seq_HPCs_Mouse0.81688841
127PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.81272587
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81010162
129NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.79592904
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78889663
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78759276
132MYC_18940864_ChIP-ChIP_HL60_Human0.78551343
133AR_21572438_ChIP-Seq_LNCaP_Human0.77965635
134THAP11_20581084_ChIP-Seq_MESCs_Mouse0.77350397
135KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77202930
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.76970258
137NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76320176
138SMAD3_21741376_ChIP-Seq_EPCs_Human0.75705163
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.75700707
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74042985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy8.82682515
2MP0010386_abnormal_urinary_bladder5.42076124
3MP0002751_abnormal_autonomic_nervous4.39440365
4MP0002009_preneoplasia3.50584787
5MP0002653_abnormal_ependyma_morphology3.47148364
6MP0000538_abnormal_urinary_bladder3.44162627
7MP0003123_paternal_imprinting3.39944833
8MP0003787_abnormal_imprinting3.33933050
9MP0003122_maternal_imprinting3.18303316
10* MP0002638_abnormal_pupillary_reflex3.08522431
11MP0004858_abnormal_nervous_system3.03074855
12MP0005645_abnormal_hypothalamus_physiol2.58935927
13MP0001905_abnormal_dopamine_level2.41248707
14MP0004270_analgesia2.38997236
15MP0001529_abnormal_vocalization2.24717260
16MP0001440_abnormal_grooming_behavior2.16226993
17MP0006276_abnormal_autonomic_nervous2.05167736
18MP0009745_abnormal_behavioral_response1.99646069
19MP0008877_abnormal_DNA_methylation1.98670367
20MP0003567_abnormal_fetal_cardiomyocyte1.88028917
21MP0002734_abnormal_mechanical_nocicepti1.85759580
22MP0003942_abnormal_urinary_system1.80055787
23MP0008961_abnormal_basal_metabolism1.76435372
24MP0008872_abnormal_physiological_respon1.72723255
25MP0002909_abnormal_adrenal_gland1.72248914
26MP0000049_abnormal_middle_ear1.69047647
27MP0002733_abnormal_thermal_nociception1.64116531
28MP0001970_abnormal_pain_threshold1.62343761
29MP0001501_abnormal_sleep_pattern1.62282803
30MP0005646_abnormal_pituitary_gland1.57188078
31MP0003635_abnormal_synaptic_transmissio1.53904124
32MP0002184_abnormal_innervation1.53785648
33MP0000778_abnormal_nervous_system1.42850061
34* MP0005197_abnormal_uvea_morphology1.33783064
35MP0006138_congestive_heart_failure1.33691476
36MP0002572_abnormal_emotion/affect_behav1.33267315
37MP0009379_abnormal_foot_pigmentation1.33149240
38MP0003121_genomic_imprinting1.32362074
39MP0004142_abnormal_muscle_tone1.28294380
40MP0005408_hypopigmentation1.27417087
41MP0004924_abnormal_behavior1.24341781
42MP0005386_behavior/neurological_phenoty1.24341781
43MP0002064_seizures1.14990378
44MP0001270_distended_abdomen1.14985682
45MP0001756_abnormal_urination1.13318273
46MP0002063_abnormal_learning/memory/cond1.10966077
47MP0005623_abnormal_meninges_morphology1.06160634
48* MP0000955_abnormal_spinal_cord1.05390095
49MP0000534_abnormal_ureter_morphology1.02747772
50MP0004233_abnormal_muscle_weight1.02351578
51MP0006072_abnormal_retinal_apoptosis1.02320337
52MP0004859_abnormal_synaptic_plasticity1.01450036
53MP0005409_darkened_coat_color1.01338680
54MP0003115_abnormal_respiratory_system1.00002570
55MP0002272_abnormal_nervous_system0.99655645
56MP0000372_irregular_coat_pigmentation0.99440982
57MP0003646_muscle_fatigue0.99279616
58MP0003077_abnormal_cell_cycle0.98884609
59MP0000762_abnormal_tongue_morphology0.98048934
60MP0003935_abnormal_craniofacial_develop0.97660789
61MP0000003_abnormal_adipose_tissue0.94883297
62MP0000427_abnormal_hair_cycle0.92729993
63MP0001299_abnormal_eye_distance/0.92622339
64MP0000751_myopathy0.91861009
65MP0005253_abnormal_eye_physiology0.91354467
66MP0003937_abnormal_limbs/digits/tail_de0.90153185
67MP0002557_abnormal_social/conspecific_i0.89431598
68MP0008932_abnormal_embryonic_tissue0.88938488
69MP0008569_lethality_at_weaning0.86513963
70MP0005423_abnormal_somatic_nervous0.84958993
71MP0000477_abnormal_intestine_morphology0.84496139
72MP0001984_abnormal_olfaction0.83312998
73* MP0002081_perinatal_lethality0.83169634
74MP0002163_abnormal_gland_morphology0.82867947
75* MP0004811_abnormal_neuron_physiology0.82187380
76MP0009250_abnormal_appendicular_skeleto0.81818531
77* MP0002152_abnormal_brain_morphology0.81664357
78MP0000631_abnormal_neuroendocrine_gland0.79657077
79MP0004883_abnormal_blood_vessel0.79420963
80* MP0002127_abnormal_cardiovascular_syste0.79169418
81* MP0002882_abnormal_neuron_morphology0.78914225
82MP0003638_abnormal_response/metabolism_0.78670654
83MP0005076_abnormal_cell_differentiation0.78344362
84MP0008770_decreased_survivor_rate0.77695449
85MP0002069_abnormal_eating/drinking_beha0.77628847
86MP0004085_abnormal_heartbeat0.77171023
87MP0002085_abnormal_embryonic_tissue0.76962694
88MP0010094_abnormal_chromosome_stability0.76051718
89* MP0002752_abnormal_somatic_nervous0.75817713
90MP0003868_abnormal_feces_composition0.75232803
91MP0002932_abnormal_joint_morphology0.75101732
92MP0003329_amyloid_beta_deposits0.73805032
93MP0000759_abnormal_skeletal_muscle0.72784325
94MP0005083_abnormal_biliary_tract0.72444359
95MP0002109_abnormal_limb_morphology0.72404825
96MP0003279_aneurysm0.72302804
97MP0003959_abnormal_lean_body0.71805203
98MP0005503_abnormal_tendon_morphology0.71547025
99MP0001346_abnormal_lacrimal_gland0.71201608
100MP0002066_abnormal_motor_capabilities/c0.70660234
101MP0009672_abnormal_birth_weight0.70638171
102MP0000639_abnormal_adrenal_gland0.70335519
103MP0004130_abnormal_muscle_cell0.70332638
104MP0000681_abnormal_thyroid_gland0.70265311
105MP0003111_abnormal_nucleus_morphology0.70233658
106MP0005187_abnormal_penis_morphology0.70233234
107MP0002114_abnormal_axial_skeleton0.70002446
108* MP0001943_abnormal_respiration0.68598726
109MP0001664_abnormal_digestion0.68477367
110MP0003315_abnormal_perineum_morphology0.68439419
111* MP0003948_abnormal_gas_homeostasis0.67949435
112MP0003633_abnormal_nervous_system0.67808954
113MP0002084_abnormal_developmental_patter0.67643108
114MP0008874_decreased_physiological_sensi0.67550230
115MP0006292_abnormal_olfactory_placode0.66855251
116MP0009046_muscle_twitch0.66742762
117MP0002249_abnormal_larynx_morphology0.65672062
118MP0003705_abnormal_hypodermis_morpholog0.65623228
119MP0002067_abnormal_sensory_capabilities0.65102495
120MP0003861_abnormal_nervous_system0.63312554
121MP0001340_abnormal_eyelid_morphology0.62643403
122MP0008057_abnormal_DNA_replication0.62213901
123MP0002735_abnormal_chemical_nociception0.60841766
124* MP0003631_nervous_system_phenotype0.60506779
125MP0001730_embryonic_growth_arrest0.59908159
126MP0000537_abnormal_urethra_morphology0.58174297
127* MP0010770_preweaning_lethality0.57682554
128* MP0002082_postnatal_lethality0.57682554
129MP0001348_abnormal_lacrimal_gland0.57084292
130MP0001188_hyperpigmentation0.56275391
131MP0002116_abnormal_craniofacial_bone0.56060324
132* MP0010769_abnormal_survival0.55913157
133MP0009703_decreased_birth_body0.55666893
134MP0003045_fibrosis0.54637870
135MP0003755_abnormal_palate_morphology0.54137334
136MP0002697_abnormal_eye_size0.54056510
137* MP0010768_mortality/aging0.53943627

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)8.57686980
2Orthostatic hypotension (HP:0001278)7.70922093
3Hyperthyroidism (HP:0000836)6.20297193
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.13616422
5Neonatal hypoglycemia (HP:0001998)6.11931932
6Amblyopia (HP:0000646)6.07658878
7Abnormal autonomic nervous system physiology (HP:0012332)5.57493682
8Enlarged penis (HP:0000040)5.52225043
9Exotropia (HP:0000577)5.39603956
10Myokymia (HP:0002411)5.10066463
11Agitation (HP:0000713)5.06215976
12Menstrual irregularities (HP:0000858)4.96573712
13Hypercortisolism (HP:0001578)4.92231847
14Abnormality of the phalanges of the 2nd finger (HP:0009541)4.86769833
15Abnormality of calcium-phosphate metabolism (HP:0100530)4.56858559
16Esophageal atresia (HP:0002032)4.37194856
17Abnormality of the corticospinal tract (HP:0002492)4.26611012
18Growth hormone excess (HP:0000845)4.17195560
19Pheochromocytoma (HP:0002666)3.94672862
20Intestinal atresia (HP:0011100)3.91327265
21Abnormality of the phalanges of the hallux (HP:0010057)3.89689727
22Limb dystonia (HP:0002451)3.85580808
23Shawl scrotum (HP:0000049)3.85578318
24Hyperparathyroidism (HP:0000843)3.83045656
25Degeneration of the lateral corticospinal tracts (HP:0002314)3.80316752
26Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.80316752
27Breast hypoplasia (HP:0003187)3.79804586
28Impulsivity (HP:0100710)3.55409044
29Testicular neoplasm (HP:0010788)3.52237617
30Hypotension (HP:0002615)3.49442717
31External ophthalmoplegia (HP:0000544)3.49023254
32Restlessness (HP:0000711)3.43650280
33Neuroendocrine neoplasm (HP:0100634)3.43010521
34Abnormality of the 2nd finger (HP:0004100)3.23340306
35Annular pancreas (HP:0001734)3.19727044
36Hypoplastic nipples (HP:0002557)3.17631356
37Midline defect of the nose (HP:0004122)3.14160994
38Malnutrition (HP:0004395)3.12997584
39Macroorchidism (HP:0000053)3.10342322
40Goiter (HP:0000853)2.96324384
41Depressed nasal tip (HP:0000437)2.91102569
42Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.83895279
43Abnormality of the vocal cords (HP:0008777)2.78148505
44Partial duplication of the phalanx of hand (HP:0009999)2.74559321
45Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.74530542
46Bowel diverticulosis (HP:0005222)2.71007401
47Thyroid carcinoma (HP:0002890)2.70580021
48Gastrointestinal atresia (HP:0002589)2.68654136
49Potter facies (HP:0002009)2.68577638
50Facial shape deformation (HP:0011334)2.68577638
51Myotonia (HP:0002486)2.67470849
52Striae distensae (HP:0001065)2.66822523
53Palpebral edema (HP:0100540)2.66153088
54Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.63259562
55Tubulointerstitial fibrosis (HP:0005576)2.61645865
56Patellar aplasia (HP:0006443)2.58661183
57Abnormality of the parietal bone (HP:0002696)2.58289045
58Adrenal overactivity (HP:0002717)2.56798618
59Hyperphosphatemia (HP:0002905)2.56296680
60Neoplasm of the peripheral nervous system (HP:0100007)2.55539609
61Failure to thrive in infancy (HP:0001531)2.54205744
62Neoplasm of the thyroid gland (HP:0100031)2.53053508
63Long toe (HP:0010511)2.51407680
64Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.49645913
65Abnormality of aromatic amino acid family metabolism (HP:0004338)2.49627799
66Abnormality of the 4th metacarpal (HP:0010012)2.48289208
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.48111428
68Short 4th metacarpal (HP:0010044)2.48111428
69Turricephaly (HP:0000262)2.46336359
70Action tremor (HP:0002345)2.42770302
71Abnormality of the phalanges of the 5th finger (HP:0004213)2.42734950
72Generalized hypotonia (HP:0001290)2.42521384
73Abnormality of the parathyroid morphology (HP:0011766)2.36782562
74Neonatal onset (HP:0003623)2.34772541
75Intestinal polyposis (HP:0200008)2.33450385
76High anterior hairline (HP:0009890)2.33415744
77Sandal gap (HP:0001852)2.32269197
78Aplasia/Hypoplasia of the patella (HP:0006498)2.31381228
79Hypotrichosis (HP:0001006)2.30252943
80Partial agenesis of the corpus callosum (HP:0001338)2.26597273
81Type 2 muscle fiber atrophy (HP:0003554)2.26529903
82Sacral dimple (HP:0000960)2.26044020
83Episodic fever (HP:0001954)2.22667490
84Cranial hyperostosis (HP:0004437)2.22041356
85Cerebral hemorrhage (HP:0001342)2.20813622
86Hyperacusis (HP:0010780)2.17416797
87Arthropathy (HP:0003040)2.17302103
88Morphological abnormality of the pyramidal tract (HP:0002062)2.15663013
89Tubulointerstitial abnormality (HP:0001969)2.14245175
90* Hypoventilation (HP:0002791)2.13500605
91Supernumerary spleens (HP:0009799)2.12602890
92Intestinal polyp (HP:0005266)2.11286866
93Wide anterior fontanel (HP:0000260)2.10387402
94Abnormality of pain sensation (HP:0010832)2.09096316
95Impaired pain sensation (HP:0007328)2.09096316
96Depression (HP:0000716)2.07402632
97Anxiety (HP:0000739)2.07258174
98Delayed cranial suture closure (HP:0000270)2.05938400
99Sex reversal (HP:0012245)2.05854144
100Abnormal sex determination (HP:0012244)2.05854144
101Postural tremor (HP:0002174)2.05612758
102Pseudobulbar signs (HP:0002200)2.01530629
103Poor suck (HP:0002033)2.01258943
104Hypothermia (HP:0002045)11.3127929
105Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98970125
106Facial asymmetry (HP:0000324)1.98093857
107Abnormal hemoglobin (HP:0011902)1.96123501
108Cortical dysplasia (HP:0002539)1.95778248
109Focal seizures (HP:0007359)1.95298821
110Degeneration of anterior horn cells (HP:0002398)1.95158032
111Abnormality of the anterior horn cell (HP:0006802)1.95158032
112Muscle fiber atrophy (HP:0100295)1.94425713
113Abnormality of the aortic arch (HP:0012303)1.91863154
114Aplasia/Hypoplasia of the nipples (HP:0006709)1.91527192
115Hypoparathyroidism (HP:0000829)1.91026214
116Renovascular hypertension (HP:0100817)1.90305138
117Autoamputation (HP:0001218)1.90298012
118Precocious puberty (HP:0000826)1.88797042
119Ulnar claw (HP:0001178)1.88053663
120Buphthalmos (HP:0000557)1.84941975
121Aqueductal stenosis (HP:0002410)1.82047159
122Thick eyebrow (HP:0000574)1.81192570
123Rhinitis (HP:0012384)1.80963238
124Stenosis of the external auditory canal (HP:0000402)1.80779001
125Long nose (HP:0003189)1.80125390
126Neoplasm of the heart (HP:0100544)1.79680972
127Renal dysplasia (HP:0000110)1.76954966
128Short palpebral fissure (HP:0012745)1.75865037
129Ectopic kidney (HP:0000086)1.73898832
130Delusions (HP:0000746)1.73777924
131Bicornuate uterus (HP:0000813)1.72231848
132Increased corneal curvature (HP:0100692)1.71249221
133Keratoconus (HP:0000563)1.71249221
134Absent radius (HP:0003974)1.70344403
135Cutaneous finger syndactyly (HP:0010554)1.69236136
136Secondary amenorrhea (HP:0000869)1.67642759
137Abnormality of the distal phalanx of the thumb (HP:0009617)1.67603332
138Elfin facies (HP:0004428)1.67548814
139Abnormal gallbladder physiology (HP:0012438)1.67351651
140Cholecystitis (HP:0001082)1.67351651
141Bony spicule pigmentary retinopathy (HP:0007737)1.65624426
142Hammertoe (HP:0001765)1.65534124
143Limb hypertonia (HP:0002509)1.65114745
144Obsessive-compulsive behavior (HP:0000722)1.64598863
145Sensory axonal neuropathy (HP:0003390)1.64270863
146Hypoproteinemia (HP:0003075)1.63397863
147Single transverse palmar crease (HP:0000954)1.63339930
148Chromsome breakage (HP:0040012)1.62913664
149Self-mutilation (HP:0000742)1.62844776
150Brachycephaly (HP:0000248)1.62150567
151Spina bifida occulta (HP:0003298)1.60689085
152Round face (HP:0000311)1.60299528
153Short metatarsal (HP:0010743)1.57895451
154Sleep apnea (HP:0010535)1.55494293
155Thickened calvaria (HP:0002684)1.55332226
156Psychosis (HP:0000709)1.53743144
157Pathologic fracture (HP:0002756)1.51509089
158Wrist flexion contracture (HP:0001239)1.51420221
159Morphological abnormality of the middle ear (HP:0008609)1.51277925
160Hyperpituitarism (HP:0010514)1.50999157
161Supranuclear gaze palsy (HP:0000605)1.49901731
162Recurrent corneal erosions (HP:0000495)1.49802411
163Osteopenia (HP:0000938)1.48084322
164Generalized tonic-clonic seizures (HP:0002069)1.44373791
165Abnormality of the pulmonary veins (HP:0011718)1.43138456
166Torticollis (HP:0000473)1.43062378
167Craniofacial dystonia (HP:0012179)1.42847797
168Emotional lability (HP:0000712)1.42711427
169Truncus arteriosus (HP:0001660)1.42010127
170Atonic seizures (HP:0010819)1.41244169
171Abnormal pupillary function (HP:0007686)1.41160785
172Adducted thumb (HP:0001181)1.40236326
173Hypocalcemia (HP:0002901)1.39964664
174Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.38907873
175Steatorrhea (HP:0002570)1.38727342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK16.97635567
2MAP3K105.28192774
3GRK74.29029591
4PNCK3.40546877
5PLK42.87351255
6MATK2.75491937
7GRK52.73390758
8TGFBR12.58241352
9NTRK32.53747779
10UHMK12.51131551
11ICK2.48816773
12CSNK1G32.46386273
13TLK12.20644096
14BMPR1B2.19265150
15ZAK1.99369302
16CSNK1G21.91717931
17DAPK21.87722611
18MAP3K41.76043984
19CSNK1G11.72212525
20ADRBK11.71161879
21MAP2K11.69195247
22FLT31.67117397
23PTK21.60926198
24BRD41.60760966
25MKNK11.60085756
26MINK11.57864571
27NME11.56330078
28LIMK11.55932136
29PDGFRA1.55887293
30MARK11.53561599
31DYRK1B1.52281567
32BUB11.51255073
33MAPKAPK51.47575947
34TYRO31.46880365
35CDC71.42172675
36EPHB21.31103309
37TRIB31.22366879
38SCYL21.19435605
39DYRK21.17867757
40FGFR21.17616550
41PBK1.14551393
42RET1.09600031
43CDK121.08798015
44CAMK11.08712886
45CSNK1A1L1.08226301
46EEF2K1.06234860
47PAK61.03584493
48MET1.02814818
49NTRK21.02661845
50MAPK131.01597009
51CDK190.99618666
52KSR20.98678714
53RIPK10.98166256
54MAP3K90.97621290
55CAMK40.94729155
56CAMK1G0.94669143
57RPS6KA20.94520368
58PKN10.93066182
59EIF2AK20.92213108
60ADRBK20.91759882
61IRAK20.90660922
62ERBB20.90102979
63SRPK10.88683432
64MTOR0.88464369
65PLK20.88193605
66SGK2230.83732265
67SGK4940.83732265
68CAMKK10.83440754
69DDR20.83199453
70CHEK20.82411493
71CDK40.82168599
72MAP3K20.81271861
73CSNK1E0.80896070
74ATR0.78900758
75TSSK60.78263138
76CAMK1D0.75959828
77CDK140.73483392
78CDK150.73358511
79ALK0.73084380
80STK240.71813389
81LATS20.71262878
82CDK11A0.70328157
83PAK30.70031205
84SGK20.70029637
85CDK180.69982640
86MAP2K70.67386862
87INSRR0.66559423
88KSR10.65870886
89PHKG10.65427052
90PHKG20.65427052
91RPS6KL10.62106838
92RPS6KC10.62106838
93ERBB30.60879948
94PDGFRB0.60746433
95GSK3A0.60369631
96CDK50.60304704
97PRKAA10.60123359
98AURKA0.59573460
99PRKCG0.59399084
100WEE10.59269337
101SIK20.58320186
102AKT30.58284112
103DAPK30.57235278
104MAPK40.55635826
105CASK0.55412043
106CDK20.55162183
107IRAK10.54032900
108FGR0.53273518
109MAP2K20.51096683
110STK110.50170233
111IGF1R0.50133052
112VRK10.49336742
113TESK10.47247570
114CDK80.46890652
115MAP2K40.46736220
116PRKCE0.46560591
117CDK60.46458766
118DAPK10.46058784
119CAMK2G0.45873878
120MAPK110.45806717
121PRKCZ0.45664939
122MKNK20.45633269
123CAMK2B0.44738721
124MAPK80.44513757
125AKT10.44241297
126PRKACA0.43897983
127MAPK90.43461156
128CDK30.42578038
129DYRK30.42384940
130ATM0.41852980
131SIK10.40660571
132FGFR10.40484966
133PASK0.39834821
134GRK60.39384776
135PRKCB0.39126578
136CDK10.38881478
137RPS6KA60.38834159
138CHEK10.38320982
139NME20.37699818
140DYRK1A0.37475423
141FGFR40.37118455
142CAMK2A0.35977408
143MARK20.34981783
144ZAP700.33464542
145SRC0.32678690
146LMTK20.31998169
147ILK0.30674802

Predicted pathways (KEGG)

RankGene SetZ-score
1Tyrosine metabolism_Homo sapiens_hsa003504.32328413
2Phenylalanine metabolism_Homo sapiens_hsa003604.14281687
3Cocaine addiction_Homo sapiens_hsa050303.28953354
4Amphetamine addiction_Homo sapiens_hsa050312.72584114
5Oxidative phosphorylation_Homo sapiens_hsa001902.69401910
6Parkinsons disease_Homo sapiens_hsa050122.67593097
7Histidine metabolism_Homo sapiens_hsa003402.41804080
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.39769846
9Non-small cell lung cancer_Homo sapiens_hsa052232.32664948
10Cholinergic synapse_Homo sapiens_hsa047252.28381682
11Dopaminergic synapse_Homo sapiens_hsa047282.24958961
12Arginine and proline metabolism_Homo sapiens_hsa003302.12195843
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08878186
14Serotonergic synapse_Homo sapiens_hsa047262.06222322
15Alzheimers disease_Homo sapiens_hsa050102.03909591
16Systemic lupus erythematosus_Homo sapiens_hsa053222.02473025
17Ribosome_Homo sapiens_hsa030101.95293838
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94798057
19DNA replication_Homo sapiens_hsa030301.92133785
20Renin secretion_Homo sapiens_hsa049241.85553876
21Long-term depression_Homo sapiens_hsa047301.85376379
22Spliceosome_Homo sapiens_hsa030401.84705483
23Synaptic vesicle cycle_Homo sapiens_hsa047211.74861173
24Huntingtons disease_Homo sapiens_hsa050161.74806092
25RNA polymerase_Homo sapiens_hsa030201.74472626
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73889760
27Circadian entrainment_Homo sapiens_hsa047131.68953242
28Cell cycle_Homo sapiens_hsa041101.63744651
29Vibrio cholerae infection_Homo sapiens_hsa051101.61927908
30Salivary secretion_Homo sapiens_hsa049701.55604649
31ErbB signaling pathway_Homo sapiens_hsa040121.52525821
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.50218459
33mRNA surveillance pathway_Homo sapiens_hsa030151.49732513
34Bile secretion_Homo sapiens_hsa049761.48577289
35Tryptophan metabolism_Homo sapiens_hsa003801.46091584
36Ovarian steroidogenesis_Homo sapiens_hsa049131.44318417
37Chronic myeloid leukemia_Homo sapiens_hsa052201.42955380
38Gap junction_Homo sapiens_hsa045401.42834949
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36142914
40Colorectal cancer_Homo sapiens_hsa052101.34249910
41Fanconi anemia pathway_Homo sapiens_hsa034601.33209214
42Proteasome_Homo sapiens_hsa030501.30377436
43Insulin secretion_Homo sapiens_hsa049111.29341383
44Cardiac muscle contraction_Homo sapiens_hsa042601.28909817
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26716320
46MicroRNAs in cancer_Homo sapiens_hsa052061.26364082
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26182126
48Arginine biosynthesis_Homo sapiens_hsa002201.26099313
49GnRH signaling pathway_Homo sapiens_hsa049121.22763609
50Lysine degradation_Homo sapiens_hsa003101.22556106
51RNA transport_Homo sapiens_hsa030131.22270784
52Thyroid cancer_Homo sapiens_hsa052161.19292976
53Alcoholism_Homo sapiens_hsa050341.18357251
54Prolactin signaling pathway_Homo sapiens_hsa049171.17352183
55Endometrial cancer_Homo sapiens_hsa052131.12228405
56Estrogen signaling pathway_Homo sapiens_hsa049151.10154094
57Non-homologous end-joining_Homo sapiens_hsa034501.09520517
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09303094
59Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06747882
60Gastric acid secretion_Homo sapiens_hsa049711.01918111
61Central carbon metabolism in cancer_Homo sapiens_hsa052301.01700280
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99975443
63Pyrimidine metabolism_Homo sapiens_hsa002400.96714250
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.95729543
65Melanogenesis_Homo sapiens_hsa049160.95155518
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94947705
67Pancreatic secretion_Homo sapiens_hsa049720.94668179
68Long-term potentiation_Homo sapiens_hsa047200.94157488
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92950209
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92680150
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90192840
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.88944999
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87907703
74Thyroid hormone synthesis_Homo sapiens_hsa049180.87697529
75Prostate cancer_Homo sapiens_hsa052150.87428488
76Glutamatergic synapse_Homo sapiens_hsa047240.86996000
77Mismatch repair_Homo sapiens_hsa034300.86964746
78Prion diseases_Homo sapiens_hsa050200.86335759
79Melanoma_Homo sapiens_hsa052180.85308563
80Basal cell carcinoma_Homo sapiens_hsa052170.84667632
81Hedgehog signaling pathway_Homo sapiens_hsa043400.84229804
82mTOR signaling pathway_Homo sapiens_hsa041500.83794059
83Base excision repair_Homo sapiens_hsa034100.83414625
84Collecting duct acid secretion_Homo sapiens_hsa049660.79409107
85Axon guidance_Homo sapiens_hsa043600.77419252
86VEGF signaling pathway_Homo sapiens_hsa043700.75523084
87Taste transduction_Homo sapiens_hsa047420.75339875
88Glucagon signaling pathway_Homo sapiens_hsa049220.73973414
89Oxytocin signaling pathway_Homo sapiens_hsa049210.73966407
90Olfactory transduction_Homo sapiens_hsa047400.72055154
91Glycerolipid metabolism_Homo sapiens_hsa005610.69446513
92Pancreatic cancer_Homo sapiens_hsa052120.67560875
93Calcium signaling pathway_Homo sapiens_hsa040200.67522218
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67305433
95Oocyte meiosis_Homo sapiens_hsa041140.66641146
96AMPK signaling pathway_Homo sapiens_hsa041520.66300388
97Bladder cancer_Homo sapiens_hsa052190.65532765
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65515715
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64891947
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64596048
101Dorso-ventral axis formation_Homo sapiens_hsa043200.63070268
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62697351
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60083766
104TGF-beta signaling pathway_Homo sapiens_hsa043500.59319810
105Basal transcription factors_Homo sapiens_hsa030220.58068539
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.57930086
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57755587
108Renal cell carcinoma_Homo sapiens_hsa052110.56872771
109Viral carcinogenesis_Homo sapiens_hsa052030.56234318
110Morphine addiction_Homo sapiens_hsa050320.54833004
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54418384
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.52660555
113Fatty acid elongation_Homo sapiens_hsa000620.50511958
114Pathways in cancer_Homo sapiens_hsa052000.50437092
115FoxO signaling pathway_Homo sapiens_hsa040680.49247653
116Hippo signaling pathway_Homo sapiens_hsa043900.47572630
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47518881
118Steroid biosynthesis_Homo sapiens_hsa001000.47023624
119Dilated cardiomyopathy_Homo sapiens_hsa054140.46818718
120Choline metabolism in cancer_Homo sapiens_hsa052310.46121637
121cAMP signaling pathway_Homo sapiens_hsa040240.45441392
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.44406074
123African trypanosomiasis_Homo sapiens_hsa051430.43597842
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43298366
125Type II diabetes mellitus_Homo sapiens_hsa049300.42647738
126Amoebiasis_Homo sapiens_hsa051460.42248100
127Platelet activation_Homo sapiens_hsa046110.42207661
128Glioma_Homo sapiens_hsa052140.39433348
129Wnt signaling pathway_Homo sapiens_hsa043100.39216989
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34684214
131Phagosome_Homo sapiens_hsa041450.34206595
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.31423458
133Notch signaling pathway_Homo sapiens_hsa043300.29284590
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.27083635
135Insulin signaling pathway_Homo sapiens_hsa049100.26235973
136Butanoate metabolism_Homo sapiens_hsa006500.26022693
137GABAergic synapse_Homo sapiens_hsa047270.25341221
138Nicotine addiction_Homo sapiens_hsa050330.25272751
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25176638
140Rap1 signaling pathway_Homo sapiens_hsa040150.23426788
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19743572
142Biosynthesis of amino acids_Homo sapiens_hsa012300.18288102
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16774947
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16337599
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.15872298
146Fructose and mannose metabolism_Homo sapiens_hsa000510.14754118

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