PHPT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.58667916
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.52652327
3ATP synthesis coupled proton transport (GO:0015986)6.52652327
4ribosomal small subunit assembly (GO:0000028)5.72513626
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.46273042
6protein complex biogenesis (GO:0070271)5.01009913
7respiratory electron transport chain (GO:0022904)4.92088469
8viral transcription (GO:0019083)4.91811928
9electron transport chain (GO:0022900)4.84666598
10DNA deamination (GO:0045006)4.72989956
11translational termination (GO:0006415)4.68087982
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.64041739
13NADH dehydrogenase complex assembly (GO:0010257)4.64041739
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.64041739
15mitochondrial respiratory chain complex assembly (GO:0033108)4.59421748
16oxidative phosphorylation (GO:0006119)4.57194130
17chaperone-mediated protein transport (GO:0072321)4.52202912
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.42508840
19ribosomal small subunit biogenesis (GO:0042274)4.42487899
20cotranslational protein targeting to membrane (GO:0006613)4.42117207
21cullin deneddylation (GO:0010388)4.40864802
22protein targeting to ER (GO:0045047)4.33920722
23proteasome assembly (GO:0043248)4.31031651
24maturation of SSU-rRNA (GO:0030490)4.23061632
25hydrogen ion transmembrane transport (GO:1902600)4.18492745
26translational elongation (GO:0006414)4.16936456
27protein localization to endoplasmic reticulum (GO:0070972)4.14043853
28regulation of mitochondrial translation (GO:0070129)4.13679548
29establishment of protein localization to endoplasmic reticulum (GO:0072599)4.09433192
30protein neddylation (GO:0045116)4.07261737
31protein deneddylation (GO:0000338)4.04740853
32cellular protein complex disassembly (GO:0043624)3.74449449
33viral life cycle (GO:0019058)3.74290090
34cytochrome complex assembly (GO:0017004)3.71681149
35GTP biosynthetic process (GO:0006183)3.70692458
36proton transport (GO:0015992)3.69296798
37hydrogen transport (GO:0006818)3.61586096
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59404206
39termination of RNA polymerase III transcription (GO:0006386)3.58802717
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.58802717
41purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.58736870
42respiratory chain complex IV assembly (GO:0008535)3.58675132
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.57062494
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.57062494
45translation (GO:0006412)3.56886220
46ATP biosynthetic process (GO:0006754)3.55320987
47L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.53935023
48purine nucleoside triphosphate biosynthetic process (GO:0009145)3.52897386
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.52104108
507-methylguanosine mRNA capping (GO:0006370)3.48616431
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.47885082
52RNA capping (GO:0036260)3.41800804
537-methylguanosine RNA capping (GO:0009452)3.41800804
54inner mitochondrial membrane organization (GO:0007007)3.41621325
55intracellular protein transmembrane import (GO:0044743)3.40814244
56aerobic respiration (GO:0009060)3.40676725
57establishment of integrated proviral latency (GO:0075713)3.39780385
58platelet dense granule organization (GO:0060155)3.37100710
59negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36911090
60negative regulation of ligase activity (GO:0051352)3.36911090
61rRNA modification (GO:0000154)3.36633699
62translational initiation (GO:0006413)3.35540774
63guanosine-containing compound biosynthetic process (GO:1901070)3.32613083
64protein complex disassembly (GO:0043241)3.28422468
65ribonucleoside triphosphate biosynthetic process (GO:0009201)3.25560256
66protein targeting to mitochondrion (GO:0006626)3.25196717
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24352148
68water-soluble vitamin biosynthetic process (GO:0042364)3.21448481
69regulation of oxidative phosphorylation (GO:0002082)3.20881288
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18504003
71protein localization to mitochondrion (GO:0070585)3.16581091
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14892833
73macromolecular complex disassembly (GO:0032984)3.12827476
74regulation of cellular amino acid metabolic process (GO:0006521)3.11729011
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11339613
76metallo-sulfur cluster assembly (GO:0031163)3.11153046
77iron-sulfur cluster assembly (GO:0016226)3.11153046
78UTP biosynthetic process (GO:0006228)3.10907132
79viral protein processing (GO:0019082)3.10670006
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.09333054
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.09333054
82establishment of protein localization to mitochondrial membrane (GO:0090151)3.09011679
83DNA damage response, detection of DNA damage (GO:0042769)3.08932704
84heart contraction (GO:0060047)3.08223996
85heart process (GO:0003015)3.08223996
86signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06598207
87signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06598207
88signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06598207
89establishment of protein localization to mitochondrion (GO:0072655)3.04157840
90mannosylation (GO:0097502)3.03509337
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02880032
92viral mRNA export from host cell nucleus (GO:0046784)3.02023626
93mitochondrial transport (GO:0006839)3.01376457
94cellular component biogenesis (GO:0044085)2.98120970
95ribosomal large subunit biogenesis (GO:0042273)2.97406813
96CTP metabolic process (GO:0046036)2.94908884
97CTP biosynthetic process (GO:0006241)2.94908884
98peptidyl-histidine modification (GO:0018202)2.94361105
99signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94148466
100signal transduction involved in DNA damage checkpoint (GO:0072422)2.94148466
101signal transduction involved in cell cycle checkpoint (GO:0072395)2.93165724
102pseudouridine synthesis (GO:0001522)2.90492574
103ubiquinone biosynthetic process (GO:0006744)2.87243114
104quinone biosynthetic process (GO:1901663)2.87243114
105spliceosomal complex assembly (GO:0000245)2.86968491
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85389761
107sequestering of actin monomers (GO:0042989)2.85264362
108nucleoside triphosphate biosynthetic process (GO:0009142)2.83627568
109pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.82523820
110protein targeting to membrane (GO:0006612)2.81142741
111aldehyde catabolic process (GO:0046185)2.80164688
112purine nucleoside monophosphate biosynthetic process (GO:0009127)2.79958233
113purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.79958233
114protein-cofactor linkage (GO:0018065)2.77002898
115intracellular protein transmembrane transport (GO:0065002)2.76560881
116UTP metabolic process (GO:0046051)2.73890869
117positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.72719449

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.75400074
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.53380526
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.45667893
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.93829964
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.92242422
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.89396369
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.85114720
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.61198997
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.43937551
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.35461607
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.17263082
12* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.14330693
13SRF_21415370_ChIP-Seq_HL-1_Mouse2.95610657
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91733723
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84561929
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.84283390
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.80726976
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.68969891
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.62366989
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.61207504
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.54045931
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37785751
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.33162294
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.29787107
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.27919723
26XRN2_22483619_ChIP-Seq_HELA_Human2.18552419
27VDR_23849224_ChIP-Seq_CD4+_Human2.15683566
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09695562
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02796044
30* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.00719558
31FOXP3_21729870_ChIP-Seq_TREG_Human1.99229173
32TTF2_22483619_ChIP-Seq_HELA_Human1.96997517
33DCP1A_22483619_ChIP-Seq_HELA_Human1.80567106
34DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.79501170
35GABP_19822575_ChIP-Seq_HepG2_Human1.72679180
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70749513
37* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.65382378
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60648078
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58862814
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57518641
41ELK1_19687146_ChIP-ChIP_HELA_Human1.56822149
42ZNF274_21170338_ChIP-Seq_K562_Hela1.56259543
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51826199
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49192807
45* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49152691
46BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.44059033
47KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40810257
48ELK1_22589737_ChIP-Seq_MCF10A_Human1.38699254
49* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38543280
50CIITA_25753668_ChIP-Seq_RAJI_Human1.34853831
51* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32782141
52CTCF_18555785_ChIP-Seq_MESCs_Mouse1.29139321
53IRF1_19129219_ChIP-ChIP_H3396_Human1.26786855
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26585822
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26079624
56MYC_18940864_ChIP-ChIP_HL60_Human1.25005374
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23917212
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23103482
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21219567
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19839295
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13960147
62* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13378060
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13268495
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11836217
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11622505
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11205134
67* TP53_22573176_ChIP-Seq_HFKS_Human1.10553666
68EZH2_22144423_ChIP-Seq_EOC_Human1.10274829
69VDR_22108803_ChIP-Seq_LS180_Human1.07940335
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07205377
71KDM5A_27292631_Chip-Seq_BREAST_Human1.06970868
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06635102
73YY1_22570637_ChIP-Seq_MALME-3M_Human1.05985849
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03499960
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.03391594
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02552611
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02372641
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01789869
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00968879
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00789332
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98332658
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97779564
83FUS_26573619_Chip-Seq_HEK293_Human0.97337345
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93737670
85EWS_26573619_Chip-Seq_HEK293_Human0.93146960
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92769702
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92162035
88HTT_18923047_ChIP-ChIP_STHdh_Human0.91400724
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90899662
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90595355
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87957733
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.87787140
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87202648
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86890755
95SOX2_16153702_ChIP-ChIP_HESCs_Human0.86105052
96IGF1R_20145208_ChIP-Seq_DFB_Human0.85141376
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.82212179
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.81871432
99* ERG_20517297_ChIP-Seq_VCAP_Human0.81458627
100MYCN_18555785_ChIP-Seq_MESCs_Mouse0.80811190
101GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80461781
102MYC_19829295_ChIP-Seq_ESCs_Human0.78995473
103AR_20517297_ChIP-Seq_VCAP_Human0.77529458
104MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.77509394
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.77215312
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.77072797
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.76781775
108* ERA_21632823_ChIP-Seq_H3396_Human0.76233275
109NANOG_20526341_ChIP-Seq_ESCs_Human0.75964016
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74928920
111STAT1_20625510_ChIP-Seq_HELA_Human0.74686286
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.74237233
113SCL_19346495_ChIP-Seq_HPC-7_Human0.74187012
114NOTCH1_21737748_ChIP-Seq_TLL_Human0.73289788
115TP63_19390658_ChIP-ChIP_HaCaT_Human0.73124439
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72704446
117CTBP1_25329375_ChIP-Seq_LNCAP_Human0.72663635
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.72478327
119GATA4_21415370_ChIP-Seq_HL-1_Mouse0.72210104
120* FOXP1_21924763_ChIP-Seq_HESCs_Human0.71707883
121CTCF_20526341_ChIP-Seq_ESCs_Human0.71523881
122NCOR_22424771_ChIP-Seq_293T_Human0.71228581
123FOXA1_25329375_ChIP-Seq_VCAP_Human0.71104703
124FOXA1_27270436_Chip-Seq_PROSTATE_Human0.71104703
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.70134453
126RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.69744725
127E2F4_17652178_ChIP-ChIP_JURKAT_Human0.69642408
128NANOG_18555785_ChIP-Seq_MESCs_Mouse0.68530988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration2.83755186
2MP0009379_abnormal_foot_pigmentation2.82303778
3MP0001529_abnormal_vocalization2.81226032
4MP0006292_abnormal_olfactory_placode2.61613981
5MP0002938_white_spotting2.50818660
6MP0001905_abnormal_dopamine_level2.33404478
7MP0008789_abnormal_olfactory_epithelium2.15342240
8MP0003122_maternal_imprinting2.06440596
9MP0003136_yellow_coat_color2.01670201
10MP0006036_abnormal_mitochondrial_physio1.94273596
11MP0001986_abnormal_taste_sensitivity1.93066364
12MP0000751_myopathy1.91048780
13MP0010030_abnormal_orbit_morphology1.87455853
14MP0000566_synostosis1.86500668
15MP0005171_absent_coat_pigmentation1.83384256
16MP0005646_abnormal_pituitary_gland1.80709159
17MP0005174_abnormal_tail_pigmentation1.74887915
18MP0000372_irregular_coat_pigmentation1.74094659
19MP0002638_abnormal_pupillary_reflex1.70557745
20MP0005075_abnormal_melanosome_morpholog1.67070027
21MP0005409_darkened_coat_color1.66383065
22MP0003950_abnormal_plasma_membrane1.66160365
23MP0003011_delayed_dark_adaptation1.65015705
24MP0004145_abnormal_muscle_electrophysio1.64210706
25MP0002653_abnormal_ependyma_morphology1.64130603
26MP0005084_abnormal_gallbladder_morpholo1.63731390
27MP0005499_abnormal_olfactory_system1.60918634
28MP0005394_taste/olfaction_phenotype1.60918634
29MP0000049_abnormal_middle_ear1.60657166
30MP0004142_abnormal_muscle_tone1.55771408
31MP0006072_abnormal_retinal_apoptosis1.54243603
32MP0004084_abnormal_cardiac_muscle1.51878080
33MP0003786_premature_aging1.50734675
34MP0002909_abnormal_adrenal_gland1.47093153
35MP0003646_muscle_fatigue1.46659532
36MP0004147_increased_porphyrin_level1.46483618
37MP0005423_abnormal_somatic_nervous1.45680446
38MP0004036_abnormal_muscle_relaxation1.45563521
39MP0001188_hyperpigmentation1.43187400
40MP0000631_abnormal_neuroendocrine_gland1.40601966
41MP0005379_endocrine/exocrine_gland_phen1.39834712
42MP0002751_abnormal_autonomic_nervous1.35545708
43MP0002132_abnormal_respiratory_system1.34986612
44MP0003137_abnormal_impulse_conducting1.33665360
45MP0003283_abnormal_digestive_organ1.33069710
46MP0003880_abnormal_central_pattern1.32524104
47MP0005332_abnormal_amino_acid1.32424735
48MP0008875_abnormal_xenobiotic_pharmacok1.31120320
49MP0002234_abnormal_pharynx_morphology1.28720418
50MP0004215_abnormal_myocardial_fiber1.28185485
51MP0006035_abnormal_mitochondrial_morpho1.27604332
52MP0001984_abnormal_olfaction1.27527678
53MP0008058_abnormal_DNA_repair1.25829192
54MP0002837_dystrophic_cardiac_calcinosis1.24463235
55MP0006276_abnormal_autonomic_nervous1.22967124
56MP0005551_abnormal_eye_electrophysiolog1.22138397
57MP0005330_cardiomyopathy1.21807335
58MP0005253_abnormal_eye_physiology1.21613004
59MP0008995_early_reproductive_senescence1.20998542
60MP0001293_anophthalmia1.20262988
61MP0008932_abnormal_embryonic_tissue1.20183738
62MP0010386_abnormal_urinary_bladder1.19198948
63MP0009046_muscle_twitch1.16754192
64MP0001485_abnormal_pinna_reflex1.16182291
65MP0004133_heterotaxia1.15993961
66MP0003942_abnormal_urinary_system1.15147722
67MP0002272_abnormal_nervous_system1.14536803
68MP0005408_hypopigmentation1.14167653
69MP0009250_abnormal_appendicular_skeleto1.12619738
70MP0002160_abnormal_reproductive_system1.12289803
71MP0003195_calcinosis1.11592579
72MP0002249_abnormal_larynx_morphology1.10738468
73MP0001756_abnormal_urination1.09879386
74MP0002277_abnormal_respiratory_mucosa1.08458387
75MP0005645_abnormal_hypothalamus_physiol1.07942475
76MP0003718_maternal_effect1.06659987
77MP0000538_abnormal_urinary_bladder1.06434732
78MP0000762_abnormal_tongue_morphology1.05805321
79MP0002876_abnormal_thyroid_physiology1.01997999
80MP0001764_abnormal_homeostasis1.01656422
81MP0002972_abnormal_cardiac_muscle1.00392258
82MP0003186_abnormal_redox_activity0.99238367
83MP0008007_abnormal_cellular_replicative0.99034692
84MP0003315_abnormal_perineum_morphology0.98898185
85MP0002090_abnormal_vision0.95878119
86MP0002822_catalepsy0.95736693
87MP0002163_abnormal_gland_morphology0.95687620
88MP0003567_abnormal_fetal_cardiomyocyte0.94528486
89MP0002102_abnormal_ear_morphology0.93390128
90MP0002106_abnormal_muscle_physiology0.92891568
91MP0004019_abnormal_vitamin_homeostasis0.92266023
92MP0004134_abnormal_chest_morphology0.91944503
93MP0002752_abnormal_somatic_nervous0.91681805
94MP0000750_abnormal_muscle_regeneration0.91317202
95MP0000026_abnormal_inner_ear0.88711294
96MP0002095_abnormal_skin_pigmentation0.88157118
97MP0003938_abnormal_ear_development0.87702889
98MP0005369_muscle_phenotype0.86898973
99MP0005377_hearing/vestibular/ear_phenot0.86699892
100MP0003878_abnormal_ear_physiology0.86699892
101MP0004085_abnormal_heartbeat0.86603857
102MP0000678_abnormal_parathyroid_gland0.86178732
103MP0003123_paternal_imprinting0.85886806
104MP0001963_abnormal_hearing_physiology0.85236880
105MP0002736_abnormal_nociception_after0.84654297
106MP0005195_abnormal_posterior_eye0.84354465
107MP0009697_abnormal_copulation0.83298948
108MP0005391_vision/eye_phenotype0.82483231
109MP0003121_genomic_imprinting0.82240408
110MP0005620_abnormal_muscle_contractility0.82023692
111MP0002127_abnormal_cardiovascular_syste0.81937986
112MP0005367_renal/urinary_system_phenotyp0.81173799
113MP0000516_abnormal_urinary_system0.81173799
114MP0004381_abnormal_hair_follicle0.80558004
115MP0002233_abnormal_nose_morphology0.78948257
116MP0002064_seizures0.76446504
117MP0002210_abnormal_sex_determination0.76213432
118MP0001944_abnormal_pancreas_morphology0.75011204
119MP0008872_abnormal_physiological_respon0.74881456
120MP0000759_abnormal_skeletal_muscle0.74643858
121MP0003806_abnormal_nucleotide_metabolis0.74543642
122MP0005636_abnormal_mineral_homeostasis0.74276078
123MP0010094_abnormal_chromosome_stability0.74186219
124MP0001324_abnormal_eye_pigmentation0.74125046
125MP0000015_abnormal_ear_pigmentation0.72875933
126MP0001919_abnormal_reproductive_system0.72449038
127MP0008569_lethality_at_weaning0.72443466
128MP0002734_abnormal_mechanical_nocicepti0.71275985
129MP0009745_abnormal_behavioral_response0.70805979
130MP0000534_abnormal_ureter_morphology0.70266190
131MP0005389_reproductive_system_phenotype0.70045232
132MP0002282_abnormal_trachea_morphology0.69785625
133MP0000778_abnormal_nervous_system0.69442209
134MP0001970_abnormal_pain_threshold0.68818736
135MP0002557_abnormal_social/conspecific_i0.68352235
136MP0001968_abnormal_touch/_nociception0.65881181

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.05039812
2Abnormal mitochondria in muscle tissue (HP:0008316)5.47553076
3Mitochondrial inheritance (HP:0001427)5.22905740
4Progressive macrocephaly (HP:0004481)4.95774562
5Hepatocellular necrosis (HP:0001404)4.78987578
6Acute encephalopathy (HP:0006846)4.70890828
7Increased CSF lactate (HP:0002490)4.45300173
8Hepatic necrosis (HP:0002605)4.28474710
9Decreased activity of mitochondrial respiratory chain (HP:0008972)4.05730179
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.05730179
11Abnormality of cells of the erythroid lineage (HP:0012130)3.74593811
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.74148490
133-Methylglutaconic aciduria (HP:0003535)3.70270036
14Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.68889296
15Renal Fanconi syndrome (HP:0001994)3.63330202
16Increased hepatocellular lipid droplets (HP:0006565)3.62660974
17Exercise intolerance (HP:0003546)3.59558671
18Abnormal number of erythroid precursors (HP:0012131)3.46658856
19Aplastic anemia (HP:0001915)3.35117562
20Optic disc pallor (HP:0000543)3.34639919
21Leukodystrophy (HP:0002415)3.30688749
22Increased serum lactate (HP:0002151)3.24586333
23Lipid accumulation in hepatocytes (HP:0006561)3.21661040
24Increased intramyocellular lipid droplets (HP:0012240)3.18205127
25Lactic acidosis (HP:0003128)3.09207909
26Abnormality of glycolysis (HP:0004366)3.03797129
27Increased serum pyruvate (HP:0003542)3.03797129
28Respiratory failure (HP:0002878)3.00052032
29Cerebral hypomyelination (HP:0006808)2.94242273
30Neuroendocrine neoplasm (HP:0100634)2.93265608
31Cerebral edema (HP:0002181)2.86838852
32Pheochromocytoma (HP:0002666)2.77615804
33Microvesicular hepatic steatosis (HP:0001414)2.72728951
34Increased muscle lipid content (HP:0009058)2.70655658
35Abnormality of midbrain morphology (HP:0002418)2.67188923
36Molar tooth sign on MRI (HP:0002419)2.67188923
37True hermaphroditism (HP:0010459)2.65914351
38Reticulocytopenia (HP:0001896)2.63147843
39Testicular atrophy (HP:0000029)2.62477507
40Lethargy (HP:0001254)2.57585977
41Rib fusion (HP:0000902)2.56345952
42Colon cancer (HP:0003003)2.49550374
43Hyperglycinemia (HP:0002154)2.42106818
44Respiratory difficulties (HP:0002880)2.41591131
45Type I transferrin isoform profile (HP:0003642)2.41478421
46Nephrogenic diabetes insipidus (HP:0009806)2.39147708
47Hypothermia (HP:0002045)2.37285366
48Exertional dyspnea (HP:0002875)2.36938104
49Hyperphosphaturia (HP:0003109)2.36062928
50Hypoplastic left heart (HP:0004383)2.35576412
51Type 2 muscle fiber atrophy (HP:0003554)2.35012778
52Limb dystonia (HP:0002451)2.32129151
53Macrocytic anemia (HP:0001972)2.30581079
54Occipital encephalocele (HP:0002085)2.28361034
55Abnormality of renal resorption (HP:0011038)2.26993277
56Methylmalonic aciduria (HP:0012120)2.24699474
57Muscle fiber atrophy (HP:0100295)2.18940687
58Abnormality of the labia minora (HP:0012880)2.16711304
59Palpitations (HP:0001962)2.13917189
60Medial flaring of the eyebrow (HP:0010747)2.13840342
61Calf muscle hypertrophy (HP:0008981)2.13761936
62Pancreatic fibrosis (HP:0100732)2.09807910
63Nephronophthisis (HP:0000090)2.08778270
64Methylmalonic acidemia (HP:0002912)2.07470465
65Congenital primary aphakia (HP:0007707)2.07284615
66Hypoplastic heart (HP:0001961)2.07018819
67Dicarboxylic aciduria (HP:0003215)2.06563404
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06563404
69Gait imbalance (HP:0002141)2.03094869
70Renal tubular dysfunction (HP:0000124)2.00734733
71Muscle hypertrophy of the lower extremities (HP:0008968)1.99258910
72Myotonia (HP:0002486)1.97576317
73Emotional lability (HP:0000712)1.93697870
74Pancreatic cysts (HP:0001737)1.90947619
75Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90098167
76Generalized aminoaciduria (HP:0002909)1.89046247
77Congenital, generalized hypertrichosis (HP:0004540)1.86991367
78Pallor (HP:0000980)1.85304753
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85152818
80Abnormal protein N-linked glycosylation (HP:0012347)1.85152818
81Abnormal protein glycosylation (HP:0012346)1.85152818
82Abnormal glycosylation (HP:0012345)1.85152818
83Abnormal urine phosphate concentration (HP:0012599)1.83646653
84Partial duplication of thumb phalanx (HP:0009944)1.82513383
85Anophthalmia (HP:0000528)1.82512919
86Hyperinsulinemic hypoglycemia (HP:0000825)1.81318624
87Absent thumb (HP:0009777)1.81276988
88Amniotic constriction ring (HP:0009775)1.80665245
89Abnormality of placental membranes (HP:0011409)1.80665245
90Hypoglycemic coma (HP:0001325)1.77515092
91Patchy hypopigmentation of hair (HP:0011365)1.76836314
92Pulmonary artery stenosis (HP:0004415)1.75221730
93Abnormality of aromatic amino acid family metabolism (HP:0004338)1.74604602
94Aplasia/hypoplasia of the uterus (HP:0008684)1.74410728
95Progressive external ophthalmoplegia (HP:0000590)1.73392414
96Exercise-induced muscle cramps (HP:0003710)1.72545651
97Vaginal atresia (HP:0000148)1.72315390
98Ketoacidosis (HP:0001993)1.72196519
99Hyperglycinuria (HP:0003108)1.71719723
100Exercise-induced myalgia (HP:0003738)1.71208767
101X-linked dominant inheritance (HP:0001423)1.70763121
102CNS demyelination (HP:0007305)1.70483635
103Hypomagnesemia (HP:0002917)1.69931337
104Large for gestational age (HP:0001520)1.68837305
105Abnormality of the anterior horn cell (HP:0006802)1.68019557
106Degeneration of anterior horn cells (HP:0002398)1.68019557
107Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.67610847
108Supernumerary spleens (HP:0009799)1.67513512
109Genital tract atresia (HP:0001827)1.67339384
110Sclerocornea (HP:0000647)1.67321857
111Weak cry (HP:0001612)1.66429316
112Nemaline bodies (HP:0003798)1.65707385
113Ragged-red muscle fibers (HP:0003200)1.65554841
114Left ventricular hypertrophy (HP:0001712)1.64936758
115Vomiting (HP:0002013)1.64054818
116Septo-optic dysplasia (HP:0100842)1.63319837
117Nonprogressive disorder (HP:0003680)1.62273857
118Irregular epiphyses (HP:0010582)1.62212963
119Cystic liver disease (HP:0006706)1.62037251
120Abnormality of the heme biosynthetic pathway (HP:0010472)1.61909121
121Blindness (HP:0000618)1.61356456
122Myokymia (HP:0002411)1.60972700
123Abnormality of magnesium homeostasis (HP:0004921)1.60899816
124Abnormality of urine glucose concentration (HP:0011016)1.60696339
125Glycosuria (HP:0003076)1.60696339
126Retinal dysplasia (HP:0007973)1.59269420
127Ketosis (HP:0001946)1.58831808
128Type II lissencephaly (HP:0007260)1.58793581
129Supraventricular tachycardia (HP:0004755)1.58570542
130CNS hypomyelination (HP:0003429)1.58336614
131Abnormality of glycine metabolism (HP:0010895)1.57802079
132Abnormality of serine family amino acid metabolism (HP:0010894)1.57802079
133Poor suck (HP:0002033)1.56844118
134Partial duplication of the phalanx of hand (HP:0009999)1.55965775
135Neoplasm of the peripheral nervous system (HP:0100007)1.55553902
136Severe visual impairment (HP:0001141)1.53806984
137Absent septum pellucidum (HP:0001331)1.53725407
138Abnormality of the septum pellucidum (HP:0007375)1.53713938
13911 pairs of ribs (HP:0000878)1.53583002
140Abnormality of the calf musculature (HP:0001430)1.52567041
141Neoplasm of the adrenal gland (HP:0100631)1.52113501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.56161878
2STK163.67099474
3CDK193.19917534
4NME22.92368751
5OBSCN2.69452369
6MYLK2.63742395
7CASK2.58057660
8VRK12.49899705
9MUSK2.44590148
10NME12.25713084
11MAP4K22.25254202
12BUB12.23468018
13LIMK12.20253948
14MKNK11.91134178
15WNK31.81808299
16SRPK11.75806308
17PIM21.71545245
18TNIK1.69018215
19NUAK11.56080116
20PINK11.51746284
21MAPKAPK51.50038293
22MKNK21.49108133
23EPHB21.48469244
24ILK1.48414204
25TESK21.45871396
26TESK11.44043221
27MAP3K121.43893067
28PHKG11.40732459
29PHKG21.40732459
30TLK11.39129927
31TRIM281.38070814
32NEK11.38009837
33ADRBK21.37948291
34CDK81.33085156
35STK391.32904712
36FRK1.32428148
37SIK31.27265164
38UHMK11.26209585
39MAPK131.25374258
40PBK1.25287108
41PDK21.23181741
42BMPR1B1.21312944
43MAP2K61.19676467
44DYRK21.17289976
45BCKDK1.13922573
46TIE11.13264729
47MAPK151.12232628
48CDC71.11393490
49CCNB11.10685466
50CSNK1G21.07231108
51TAF11.06014684
52CSNK1G11.05392495
53ZAK1.04165514
54KDR1.04094381
55MAP3K41.01253006
56INSRR0.99345136
57TGFBR10.97961724
58ABL20.95968052
59IRAK20.94914343
60PLK40.94800775
61DYRK30.94660210
62PAK30.93509679
63NEK60.91836434
64FGFR20.91811076
65TSSK60.90646111
66GRK70.90518678
67BRAF0.88693305
68BCR0.87266238
69ARAF0.87199356
70WEE10.86295503
71PLK20.85930057
72CAMK2D0.85569293
73OXSR10.85508284
74PRKCG0.83727503
75PLK10.82680509
76EIF2AK30.82616649
77PIK3CA0.81597121
78CAMK2B0.81195065
79PRKCI0.80190717
80CSNK1A1L0.77616982
81CSNK1G30.72786428
82STK240.69622727
83TAOK20.68187404
84CLK10.68001901
85PASK0.67502923
86MARK10.66853594
87MST40.65926293
88RPS6KB20.65702036
89WNK40.64506042
90BRSK10.64459915
91AURKB0.64153810
92YES10.63374806
93DAPK30.63120708
94CAMK2G0.62694872
95CHEK20.61497063
96MAP2K70.60564927
97DAPK10.59581612
98TNK20.58952501
99ROCK20.57717409
100CSNK2A10.57363383
101ADRBK10.57158947
102CDK70.56930805
103LMTK20.56822153
104AURKA0.56787215
105ACVR1B0.56457914
106MAP2K30.55738340
107GRK10.55157096
108GRK50.54739862
109IRAK40.54071776
110MAPKAPK30.54009365
111EPHA40.53719717
112PLK30.53555328
113SGK4940.52667442
114SGK2230.52667442
115TXK0.52208506
116CSNK1A10.50909939
117LRRK20.50389212
118MINK10.49116083
119STK40.48522251
120TEC0.47757387
121MAPK120.47396875
122ATR0.47291801
123CAMK10.46653040
124RPS6KA50.46365592
125EIF2AK10.46306655
126CSNK2A20.45939405
127CAMK2A0.44798435
128PRKACA0.44214655
129BTK0.43869207
130PRKCE0.43530954
131MAP3K110.43378308
132RPS6KA60.42550959
133MAPK40.42010125
134PKN10.41707736
135RPS6KC10.41261327
136TTK0.40503606
137PAK10.40381847

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.99666441
2Oxidative phosphorylation_Homo sapiens_hsa001904.82096191
3Parkinsons disease_Homo sapiens_hsa050124.56840747
4Proteasome_Homo sapiens_hsa030503.74225195
5Huntingtons disease_Homo sapiens_hsa050163.23156385
6RNA polymerase_Homo sapiens_hsa030203.22276582
7Alzheimers disease_Homo sapiens_hsa050102.98577054
8Protein export_Homo sapiens_hsa030602.98211830
9DNA replication_Homo sapiens_hsa030302.54464972
10Cardiac muscle contraction_Homo sapiens_hsa042602.52161298
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.44144057
12Mismatch repair_Homo sapiens_hsa034302.36745608
13Pyrimidine metabolism_Homo sapiens_hsa002402.18199555
14Spliceosome_Homo sapiens_hsa030402.09115250
15Nucleotide excision repair_Homo sapiens_hsa034201.93826505
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.91914331
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86504815
18Base excision repair_Homo sapiens_hsa034101.75673692
19Basal transcription factors_Homo sapiens_hsa030221.72497992
20Fatty acid elongation_Homo sapiens_hsa000621.66946784
21Homologous recombination_Homo sapiens_hsa034401.66031367
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59272925
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54703998
24Purine metabolism_Homo sapiens_hsa002301.48941178
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.47741860
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42652636
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41252570
28Butanoate metabolism_Homo sapiens_hsa006501.36077246
29RNA degradation_Homo sapiens_hsa030181.35180872
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28119291
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13392236
32Peroxisome_Homo sapiens_hsa041461.11726198
33One carbon pool by folate_Homo sapiens_hsa006701.02719617
34Fanconi anemia pathway_Homo sapiens_hsa034601.02640513
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01582978
36RNA transport_Homo sapiens_hsa030130.94197897
37Sulfur metabolism_Homo sapiens_hsa009200.92962101
38Glutathione metabolism_Homo sapiens_hsa004800.91620363
39Sulfur relay system_Homo sapiens_hsa041220.89971822
40Arachidonic acid metabolism_Homo sapiens_hsa005900.89934377
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82517495
42Pyruvate metabolism_Homo sapiens_hsa006200.82083164
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82012444
44Phototransduction_Homo sapiens_hsa047440.81063090
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80858194
46Metabolic pathways_Homo sapiens_hsa011000.79341729
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77421561
48Tryptophan metabolism_Homo sapiens_hsa003800.76799257
49Vitamin B6 metabolism_Homo sapiens_hsa007500.73914983
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72326919
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72235425
52Fatty acid metabolism_Homo sapiens_hsa012120.70586377
53Fatty acid degradation_Homo sapiens_hsa000710.68206207
54Folate biosynthesis_Homo sapiens_hsa007900.68053639
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67955329
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67369632
57Vibrio cholerae infection_Homo sapiens_hsa051100.66291806
58Non-homologous end-joining_Homo sapiens_hsa034500.66231299
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63973358
60Cell cycle_Homo sapiens_hsa041100.63163779
61Carbon metabolism_Homo sapiens_hsa012000.60360863
62Nitrogen metabolism_Homo sapiens_hsa009100.60250414
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59439030
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.58275079
65Fructose and mannose metabolism_Homo sapiens_hsa000510.58100320
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56831346
67Collecting duct acid secretion_Homo sapiens_hsa049660.56332064
68Propanoate metabolism_Homo sapiens_hsa006400.55448696
69beta-Alanine metabolism_Homo sapiens_hsa004100.55006616
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51847687
71Selenocompound metabolism_Homo sapiens_hsa004500.51804123
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51190952
73N-Glycan biosynthesis_Homo sapiens_hsa005100.50970765
74Tyrosine metabolism_Homo sapiens_hsa003500.50579284
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49810524
76Dilated cardiomyopathy_Homo sapiens_hsa054140.47630538
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47148472
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46584927
79Arginine and proline metabolism_Homo sapiens_hsa003300.45711904
80Fat digestion and absorption_Homo sapiens_hsa049750.45424036
81Galactose metabolism_Homo sapiens_hsa000520.42904653
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40404439
83Hedgehog signaling pathway_Homo sapiens_hsa043400.39285368
84Biosynthesis of amino acids_Homo sapiens_hsa012300.39132952
85Linoleic acid metabolism_Homo sapiens_hsa005910.39053801
86mRNA surveillance pathway_Homo sapiens_hsa030150.37981657
87Basal cell carcinoma_Homo sapiens_hsa052170.37399689
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37238356
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.36116889
90Serotonergic synapse_Homo sapiens_hsa047260.34690986
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34481505
92Mineral absorption_Homo sapiens_hsa049780.33848194
93Vitamin digestion and absorption_Homo sapiens_hsa049770.33810888
94Epstein-Barr virus infection_Homo sapiens_hsa051690.33769043
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29770583
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28377813
97Retinol metabolism_Homo sapiens_hsa008300.28125599
98Arginine biosynthesis_Homo sapiens_hsa002200.28021281
99Phenylalanine metabolism_Homo sapiens_hsa003600.26520530
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.25503051
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25366911
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.25035049
103Insulin secretion_Homo sapiens_hsa049110.24880196
104Pentose phosphate pathway_Homo sapiens_hsa000300.24878121
105Cocaine addiction_Homo sapiens_hsa050300.24732547
106Alcoholism_Homo sapiens_hsa050340.23863498
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22108562
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22061315
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21852669
110Autoimmune thyroid disease_Homo sapiens_hsa053200.18977424
111Ether lipid metabolism_Homo sapiens_hsa005650.18666310
112Nicotine addiction_Homo sapiens_hsa050330.18444579
113Synaptic vesicle cycle_Homo sapiens_hsa047210.18335604
114Asthma_Homo sapiens_hsa053100.17542612
115Taste transduction_Homo sapiens_hsa047420.15983785
116GABAergic synapse_Homo sapiens_hsa047270.14832733
117Circadian rhythm_Homo sapiens_hsa047100.14080190
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.10369965
119Circadian entrainment_Homo sapiens_hsa047130.10098095
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.10092701
121Chemical carcinogenesis_Homo sapiens_hsa052040.09338151
122Sphingolipid metabolism_Homo sapiens_hsa006000.08651908
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08492314
124Regulation of autophagy_Homo sapiens_hsa041400.08377752
125Steroid biosynthesis_Homo sapiens_hsa001000.08152029
126Wnt signaling pathway_Homo sapiens_hsa043100.07848457
127Morphine addiction_Homo sapiens_hsa050320.07831383

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