PHRF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibroblast apoptotic process (GO:2000270)9.83649587
2cellular extravasation (GO:0045123)9.48792287
3histone H3-K36 demethylation (GO:0070544)8.53126621
4hepatocyte apoptotic process (GO:0097284)8.26143954
5mast cell activation involved in immune response (GO:0002279)7.52502636
6mast cell degranulation (GO:0043303)7.52502636
7regulation of fibroblast apoptotic process (GO:2000269)7.04241885
8somatic diversification of immune receptors via somatic mutation (GO:0002566)5.80905564
9somatic hypermutation of immunoglobulin genes (GO:0016446)5.80905564
10T cell migration (GO:0072678)5.63481017
11mast cell activation (GO:0045576)5.13181198
12regulation of triglyceride catabolic process (GO:0010896)5.00682986
13dendritic cell chemotaxis (GO:0002407)4.82290340
14phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.70040615
15rRNA methylation (GO:0031167)4.57064229
16polyketide metabolic process (GO:0030638)4.50210270
17doxorubicin metabolic process (GO:0044598)4.50210270
18daunorubicin metabolic process (GO:0044597)4.50210270
19histone H4-K12 acetylation (GO:0043983)4.45318958
20rRNA modification (GO:0000154)4.27761143
21negative regulation of erythrocyte differentiation (GO:0045647)4.24532539
22NIK/NF-kappaB signaling (GO:0038061)4.24422020
23respiratory burst (GO:0045730)4.16781028
24lysosome localization (GO:0032418)4.06967729
25mannosylation (GO:0097502)3.98284704
26lymphocyte chemotaxis (GO:0048247)3.97763121
27inner cell mass cell proliferation (GO:0001833)3.92806756
28protein localization to endosome (GO:0036010)3.91715761
29NLS-bearing protein import into nucleus (GO:0006607)3.83648460
30CENP-A containing nucleosome assembly (GO:0034080)3.80928319
31phosphatidylinositol 3-kinase signaling (GO:0014065)3.78353141
32histone H4-K8 acetylation (GO:0043982)3.75053252
33histone H4-K5 acetylation (GO:0043981)3.75053252
34mannose metabolic process (GO:0006013)3.74412861
35leukocyte degranulation (GO:0043299)3.73901154
36nuclear pore complex assembly (GO:0051292)3.73366773
37histone lysine demethylation (GO:0070076)3.69285924
38chromatin remodeling at centromere (GO:0031055)3.64779551
39histone demethylation (GO:0016577)3.60507781
40apoptotic process involved in morphogenesis (GO:0060561)3.60430913
41nuclear pore organization (GO:0006999)3.59780256
42dendritic cell migration (GO:0036336)3.57091349
43adherens junction assembly (GO:0034333)3.54740765
44regulation of histone H3-K9 methylation (GO:0051570)3.46080815
45focal adhesion assembly (GO:0048041)3.44017163
46cell-substrate adherens junction assembly (GO:0007045)3.44017163
47germinal center formation (GO:0002467)3.41721632
48cell-substrate junction assembly (GO:0007044)3.41064346
49regulation of spindle organization (GO:0090224)3.36470863
50DNA replication-independent nucleosome assembly (GO:0006336)3.32409913
51DNA replication-independent nucleosome organization (GO:0034724)3.32409913
52hemidesmosome assembly (GO:0031581)3.30538494
53activation of Rac GTPase activity (GO:0032863)3.28687695
54histone H3-K4 trimethylation (GO:0080182)3.28665995
55lymphoid progenitor cell differentiation (GO:0002320)3.26628969
56mismatch repair (GO:0006298)3.26433795
57DNA unwinding involved in DNA replication (GO:0006268)3.21699419
58negative regulation of histone methylation (GO:0031061)3.21443191
593-UTR-mediated mRNA stabilization (GO:0070935)3.20074652
60protein demethylation (GO:0006482)3.19933829
61protein dealkylation (GO:0008214)3.19933829
62histone exchange (GO:0043486)3.15534439
63positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.14910237
64cytoskeletal anchoring at plasma membrane (GO:0007016)3.12546797
65negative regulation of cell size (GO:0045792)3.09190312
66positive regulation of Cdc42 GTPase activity (GO:0043089)3.08395390
67snRNA processing (GO:0016180)3.08109412
68embryonic process involved in female pregnancy (GO:0060136)3.07928870
69negative regulation of muscle contraction (GO:0045932)3.07135732
70Rap protein signal transduction (GO:0032486)3.06715781
71semaphorin-plexin signaling pathway (GO:0071526)3.05042006
72somatic diversification of immunoglobulins (GO:0016445)3.04903033
73regulation of glucose import in response to insulin stimulus (GO:2001273)3.04761045
74Golgi transport vesicle coating (GO:0048200)3.03352058
75COPI coating of Golgi vesicle (GO:0048205)3.03352058
76snRNA metabolic process (GO:0016073)3.01699319
77response to laminar fluid shear stress (GO:0034616)2.99559186
78epithelial cell differentiation involved in prostate gland development (GO:0060742)2.99122776
79phosphatidylinositol phosphorylation (GO:0046854)2.97616563
80histone H4-K16 acetylation (GO:0043984)2.94292764
81response to muramyl dipeptide (GO:0032495)2.93931431
82negative regulation of macroautophagy (GO:0016242)2.93661255
83regulation of early endosome to late endosome transport (GO:2000641)2.91201182
84stress fiber assembly (GO:0043149)2.89564647
85intracellular estrogen receptor signaling pathway (GO:0030520)2.87824811
86protein K6-linked ubiquitination (GO:0085020)2.87536672
87planar cell polarity pathway involved in neural tube closure (GO:0090179)2.87321863
88modulation by symbiont of host cellular process (GO:0044068)2.86528509
89IMP biosynthetic process (GO:0006188)2.86449797
90ATP-dependent chromatin remodeling (GO:0043044)2.85926932
91somatic recombination of immunoglobulin gene segments (GO:0016447)2.85910979
92histone H3-K9 methylation (GO:0051567)2.84716194
93dosage compensation (GO:0007549)2.84132869
94regulation of glial cell proliferation (GO:0060251)2.83352489
95regulation of RNA export from nucleus (GO:0046831)2.82438670
96regulation of nucleobase-containing compound transport (GO:0032239)2.82354325
97negative regulation of viral release from host cell (GO:1902187)2.82063487
98barbed-end actin filament capping (GO:0051016)2.79559799
99regulation of type I interferon-mediated signaling pathway (GO:0060338)2.79145825
100regulation of NFAT protein import into nucleus (GO:0051532)2.78974244
101pore complex assembly (GO:0046931)2.78069964
102positive regulation of histone H3-K4 methylation (GO:0051571)2.76770572
103negative regulation of lipid catabolic process (GO:0050995)2.75429662
104thymic T cell selection (GO:0045061)2.74484155
105negative regulation of fatty acid transport (GO:2000192)2.71938453
106activation of MAPKKK activity (GO:0000185)2.68320555
107mitotic sister chromatid cohesion (GO:0007064)2.66567842
108somatic diversification of immune receptors (GO:0002200)2.66510215
109DNA duplex unwinding (GO:0032508)2.66026934
110alternative mRNA splicing, via spliceosome (GO:0000380)2.65797578
111paraxial mesoderm development (GO:0048339)2.65658650
112amyloid precursor protein catabolic process (GO:0042987)2.65455161
113regulation of mammary gland epithelial cell proliferation (GO:0033599)2.64831979
114positive regulation of histone deacetylation (GO:0031065)2.64653499
115mitotic nuclear envelope disassembly (GO:0007077)2.63684734
116DNA geometric change (GO:0032392)2.62514108
117cellular response to virus (GO:0098586)2.62494507
118ncRNA 3-end processing (GO:0043628)2.61981771
119regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.61859789
120protein localization to kinetochore (GO:0034501)2.61671956
121chromatin assembly or disassembly (GO:0006333)2.60340132
122regulation of histone H3-K4 methylation (GO:0051569)2.59372645
123germ cell migration (GO:0008354)2.58706489
124regulation of histone H3-K27 methylation (GO:0061085)2.58523290
125negative regulation of heart contraction (GO:0045822)2.58255192
126histone mRNA catabolic process (GO:0071044)2.57845706
127aminoglycoside antibiotic metabolic process (GO:0030647)2.57744517
128regulation of double-strand break repair via homologous recombination (GO:0010569)2.57685128
129modulation by virus of host process (GO:0019054)2.57519111
130pinocytosis (GO:0006907)2.57190030
131lipid phosphorylation (GO:0046834)2.57152328
132positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.57014231
133T cell proliferation (GO:0042098)2.56406001
134pre-miRNA processing (GO:0031054)2.55046054
135lymphocyte migration (GO:0072676)2.54787109
136growth hormone receptor signaling pathway (GO:0060396)2.54334444
137retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.52936945
138positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.52436145
139regulation of extracellular matrix disassembly (GO:0010715)2.52220039
140spliceosomal tri-snRNP complex assembly (GO:0000244)2.51285793
141regulation of ARF GTPase activity (GO:0032312)2.50534148
142somatic cell DNA recombination (GO:0016444)2.50275048
143somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.50275048
144epithelial cell-cell adhesion (GO:0090136)2.50149348
145negative regulation of myotube differentiation (GO:0010832)2.49422034
146regulation of chromatin binding (GO:0035561)2.48493575
147glucocorticoid receptor signaling pathway (GO:0042921)2.48331886
148regulation of cholesterol homeostasis (GO:2000188)2.47345115
149positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.46700745
150mRNA stabilization (GO:0048255)2.45099821
151RNA stabilization (GO:0043489)2.45099821
152positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.44923894
153maternal placenta development (GO:0001893)2.44674929
154negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.44036424
155positive regulation of blood vessel endothelial cell migration (GO:0043536)2.43451448
156mRNA cleavage (GO:0006379)2.42695173
157cellular response to epidermal growth factor stimulus (GO:0071364)2.42351833
158regulation of gene expression by genetic imprinting (GO:0006349)2.42303563
159positive thymic T cell selection (GO:0045059)2.40089070
160insulin-like growth factor receptor signaling pathway (GO:0048009)2.37890760
161activation of JUN kinase activity (GO:0007257)2.37780415
162endothelial cell chemotaxis (GO:0035767)2.35608312
163basement membrane organization (GO:0071711)2.35425165
164signal complex assembly (GO:0007172)2.34968093
165pentose-phosphate shunt (GO:0006098)2.33849766
166antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.32289426
167response to peptidoglycan (GO:0032494)2.31179059
168atrioventricular valve morphogenesis (GO:0003181)2.30584440
169mitotic chromosome condensation (GO:0007076)2.30463719
170antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.27453133
171positive regulation of gamma-delta T cell activation (GO:0046645)2.25980131
172regulation of ARF protein signal transduction (GO:0032012)2.21936982
173apoptotic process involved in development (GO:1902742)2.21461723
174cell-cell junction maintenance (GO:0045217)2.21296046
175skin morphogenesis (GO:0043589)2.20730217
176desmosome organization (GO:0002934)2.20655888
177cortical actin cytoskeleton organization (GO:0030866)2.19490748
178regulation of integrin activation (GO:0033623)2.18292812
179positive regulation of protein deacetylation (GO:0090312)2.17366371
180positive regulation by symbiont of host defense response (GO:0052509)2.17180166
181modulation by symbiont of host defense response (GO:0052031)2.17180166
182modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.17180166
183modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.17180166
184positive regulation by organism of defense response of other organism involved in symbiotic interact2.17180166
185modulation by symbiont of host immune response (GO:0052553)2.17180166
186negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.16423814
187activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.15952554
188modulation by virus of host morphology or physiology (GO:0019048)2.14218123
189vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.14048737
190peptidyl-lysine dimethylation (GO:0018027)2.12305477

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.15025581
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.92244688
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.90194416
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.71161598
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.46095407
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.10023090
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.09598845
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.97993162
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.91455357
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.68102716
11LXR_22292898_ChIP-Seq_THP-1_Human2.61412002
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52645207
13MYC_22102868_ChIP-Seq_BL_Human2.52424361
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41316667
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33765773
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.24275316
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20690489
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.19135896
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18340232
20RACK7_27058665_Chip-Seq_MCF-7_Human2.13682591
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.11962229
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11519279
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01600422
24* FOXP3_21729870_ChIP-Seq_TREG_Human1.99840904
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93083200
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91260431
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91040281
28CIITA_25753668_ChIP-Seq_RAJI_Human1.87457308
29KDM2B_26808549_Chip-Seq_K562_Human1.85155281
30PKCTHETA_26484144_Chip-Seq_BREAST_Human1.81679025
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.79119752
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.78814035
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78288766
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78288766
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78288766
36SCL_19346495_ChIP-Seq_HPC-7_Human1.69450480
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68390328
38GATA1_22025678_ChIP-Seq_K562_Human1.68323678
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.67951399
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63417405
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62904847
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62323435
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61370576
44* VDR_21846776_ChIP-Seq_THP-1_Human1.54878506
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54454402
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53536052
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52552232
48ZNF263_19887448_ChIP-Seq_K562_Human1.52004556
49XRN2_22483619_ChIP-Seq_HELA_Human1.51938779
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51901820
51* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51860154
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51257333
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51007843
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50787908
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.50689465
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.50619528
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.48909185
58* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48720553
59TCF7_22412390_ChIP-Seq_EML_Mouse1.46434061
60* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46427520
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44940319
62EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43059654
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42784758
64CLOCK_20551151_ChIP-Seq_293T_Human1.42756797
65NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.42591899
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42536038
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.41453813
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41113907
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41031839
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40662582
71MAF_26560356_Chip-Seq_TH2_Human1.40457941
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.40156859
73* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39614181
74P68_20966046_ChIP-Seq_HELA_Human1.39371408
75* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37824902
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34416682
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33691730
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.33370010
79NCOR1_26117541_ChIP-Seq_K562_Human1.32565228
80VDR_23849224_ChIP-Seq_CD4+_Human1.32401742
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32146244
82MAF_26560356_Chip-Seq_TH1_Human1.31683232
83KDM5A_27292631_Chip-Seq_BREAST_Human1.30362570
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30062108
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29901487
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28803856
87GATA1_26923725_Chip-Seq_HPCs_Mouse1.28776417
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28723260
89SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.28212723
90CREB1_26743006_Chip-Seq_LNCaP_Human1.25992384
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.25984968
92SMC4_20622854_ChIP-Seq_HELA_Human1.25534400
93TP53_22127205_ChIP-Seq_IMR90_Human1.24242805
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23654145
95NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23250519
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22603520
97HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22193011
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21696171
99RUNX1_22412390_ChIP-Seq_EML_Mouse1.21432392
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21377853
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19775715
102ATF3_27146783_Chip-Seq_COLON_Human1.19582914
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19571060
104ERG_21242973_ChIP-ChIP_JURKAT_Human1.17095822
105PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16797478
106UTX_26944678_Chip-Seq_JUKART_Human1.16283808
107CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15875406
108SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15708986
109MYB_26560356_Chip-Seq_TH1_Human1.15597346
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15198355
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14724930
112GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13520525
113UBF1/2_26484160_Chip-Seq_HMECs_Human1.13159618
114RUNX1_27514584_Chip-Seq_MCF-7_Human1.13049394
115MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12676371
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12665955
117GATA1_19941827_ChIP-Seq_MEL_Mouse1.12510105
118EST1_17652178_ChIP-ChIP_JURKAT_Human1.12028761
119CHD1_26751641_Chip-Seq_LNCaP_Human1.11776537
120TTF2_22483619_ChIP-Seq_HELA_Human1.11509250
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11080271
122MYB_26560356_Chip-Seq_TH2_Human1.10957346
123ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10002885
124* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08556011
125POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07849822
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07570634
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05969536
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04935070
129ELF1_20517297_ChIP-Seq_JURKAT_Human1.04100577
130ELK1_19687146_ChIP-ChIP_HELA_Human1.03807469
131STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03778070
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03435735
133PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03023081
134SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02929429
135ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02488188
136SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01565850
137RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01292869
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00344320
139DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99635018
140HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99628457
141E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99425335
142KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99160097
143BCOR_27268052_Chip-Seq_Bcells_Human0.98679554
144MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98655945
145AR_21909140_ChIP-Seq_LNCAP_Human0.97699041
146SPI1_23127762_ChIP-Seq_K562_Human0.97141665
147SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96570961
148ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96524507
149* KDM2B_26808549_Chip-Seq_DND41_Human0.96256930
150DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95902365
151ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94645305
152* ELK3_25401928_ChIP-Seq_HUVEC_Human0.94336836
153SPI1_23547873_ChIP-Seq_NB4_Human0.94007304
154NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93663017
155PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92977107
156* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92867057
157STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92623926
158SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92346915
159VDR_24763502_ChIP-Seq_THP-1_Human0.91230221
160* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90809718
161* GABP_19822575_ChIP-Seq_HepG2_Human0.90717540
162PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90027553
163CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89814192
164* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88912336
165SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88002689
166FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87242329
167NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85974713
168ETS1_20019798_ChIP-Seq_JURKAT_Human0.84260143
169NANOG_16153702_ChIP-ChIP_HESCs_Human0.84011085
170IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.82840873
171HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82055210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.91271446
2MP0004084_abnormal_cardiac_muscle3.68046959
3MP0002396_abnormal_hematopoietic_system3.56347718
4MP0003111_abnormal_nucleus_morphology3.54750984
5MP0008007_abnormal_cellular_replicative3.51036461
6MP0010094_abnormal_chromosome_stability3.41578743
7MP0008058_abnormal_DNA_repair3.20026955
8MP0005451_abnormal_body_composition3.14296193
9MP0003077_abnormal_cell_cycle2.61417418
10MP0003436_decreased_susceptibility_to2.53641716
11MP0003566_abnormal_cell_adhesion2.52224965
12MP0001849_ear_inflammation2.49947203
13MP0008057_abnormal_DNA_replication2.42373749
14MP0003303_peritoneal_inflammation2.34528695
15MP0004808_abnormal_hematopoietic_stem2.29983840
16MP0008260_abnormal_autophagy2.28068892
17MP0003693_abnormal_embryo_hatching2.27808960
18MP0010234_abnormal_vibrissa_follicle2.27598256
19MP0003787_abnormal_imprinting2.22567492
20MP0005058_abnormal_lysosome_morphology2.20112162
21MP0003300_gastrointestinal_ulcer2.19226285
22MP0004185_abnormal_adipocyte_glucose2.17845868
23MP0003453_abnormal_keratinocyte_physiol2.16284589
24MP0003121_genomic_imprinting2.13799282
25MP0004947_skin_inflammation1.96374527
26MP0004858_abnormal_nervous_system1.91257842
27MP0009840_abnormal_foam_cell1.91134951
28MP0004957_abnormal_blastocyst_morpholog1.90241795
29MP0005409_darkened_coat_color1.88897689
30MP0008438_abnormal_cutaneous_collagen1.88546692
31MP0003763_abnormal_thymus_physiology1.85907017
32MP0010352_gastrointestinal_tract_polyps1.85634599
33MP0000703_abnormal_thymus_morphology1.78458600
34MP0002877_abnormal_melanocyte_morpholog1.77178342
35MP0000350_abnormal_cell_proliferation1.75509711
36MP0003122_maternal_imprinting1.72676756
37MP0004036_abnormal_muscle_relaxation1.70179143
38MP0003890_abnormal_embryonic-extraembry1.68026188
39MP0003183_abnormal_peptide_metabolism1.62503665
40MP0003943_abnormal_hepatobiliary_system1.62090351
41MP0003123_paternal_imprinting1.60122285
42MP0001188_hyperpigmentation1.57904194
43MP0004510_myositis1.57870591
44MP0003191_abnormal_cellular_cholesterol1.57536430
45MP0003172_abnormal_lysosome_physiology1.57382845
46MP0002796_impaired_skin_barrier1.55352981
47MP0001730_embryonic_growth_arrest1.54378003
48MP0000858_altered_metastatic_potential1.50605265
49MP0005076_abnormal_cell_differentiation1.47716301
50MP0005257_abnormal_intraocular_pressure1.46674619
51MP0002398_abnormal_bone_marrow1.46503500
52MP0005666_abnormal_adipose_tissue1.44625025
53MP0009333_abnormal_splenocyte_physiolog1.44196169
54MP0003786_premature_aging1.41119983
55MP0004233_abnormal_muscle_weight1.39250109
56MP0008932_abnormal_embryonic_tissue1.39035142
57MP0001800_abnormal_humoral_immune1.34342879
58MP0002254_reproductive_system_inflammat1.33058881
59MP0003705_abnormal_hypodermis_morpholog1.31937031
60MP0005464_abnormal_platelet_physiology1.31927358
61MP0004197_abnormal_fetal_growth/weight/1.31056288
62MP0003279_aneurysm1.30309352
63MP0001348_abnormal_lacrimal_gland1.29131194
64MP0000685_abnormal_immune_system1.28090669
65MP0001697_abnormal_embryo_size1.26746628
66MP0002722_abnormal_immune_system1.26205015
67MP0005375_adipose_tissue_phenotype1.25691199
68MP0002060_abnormal_skin_morphology1.25536499
69MP0002086_abnormal_extraembryonic_tissu1.25329062
70MP0000678_abnormal_parathyroid_gland1.24086478
71MP0001672_abnormal_embryogenesis/_devel1.24053541
72MP0005380_embryogenesis_phenotype1.24053541
73MP0009672_abnormal_birth_weight1.21648140
74MP0005501_abnormal_skin_physiology1.19530364
75MP0003567_abnormal_fetal_cardiomyocyte1.18608054
76MP0002085_abnormal_embryonic_tissue1.18025520
77MP0005671_abnormal_response_to1.17456367
78MP0002998_abnormal_bone_remodeling1.17147788
79MP0002089_abnormal_postnatal_growth/wei1.14243249
80MP0003937_abnormal_limbs/digits/tail_de1.14154755
81MP0004272_abnormal_basement_membrane1.12495066
82MP0002084_abnormal_developmental_patter1.11988609
83MP0005397_hematopoietic_system_phenotyp1.11627204
84MP0001545_abnormal_hematopoietic_system1.11627204
85MP0010307_abnormal_tumor_latency1.10462941
86MP0000490_abnormal_crypts_of1.10410659
87MP0000537_abnormal_urethra_morphology1.10133419
88MP0009278_abnormal_bone_marrow1.09304515
89MP0009703_decreased_birth_body1.08947803
90MP0000689_abnormal_spleen_morphology1.07031814
91MP0000003_abnormal_adipose_tissue1.06084187
92MP0002452_abnormal_antigen_presenting1.05827287
93MP0004264_abnormal_extraembryonic_tissu1.05735481
94MP0003984_embryonic_growth_retardation1.05719275
95MP0001216_abnormal_epidermal_layer1.05676672
96MP0002088_abnormal_embryonic_growth/wei1.05581330
97MP0000767_abnormal_smooth_muscle1.04822399
98MP0001873_stomach_inflammation1.04521702
99MP0000462_abnormal_digestive_system1.04477926
100MP0002419_abnormal_innate_immunity1.01319529
101MP0002429_abnormal_blood_cell1.00780312
102MP0000716_abnormal_immune_system1.00754373
103MP0001293_anophthalmia1.00715750
104MP0000313_abnormal_cell_death1.00260167
105MP0005025_abnormal_response_to1.00178471
106MP0004381_abnormal_hair_follicle0.99412340
107MP0001958_emphysema0.98942819
108MP0002420_abnormal_adaptive_immunity0.98575002
109MP0002080_prenatal_lethality0.98145406
110MP0005174_abnormal_tail_pigmentation0.97691142
111MP0005387_immune_system_phenotype0.97306184
112MP0001790_abnormal_immune_system0.97306184
113MP0006292_abnormal_olfactory_placode0.96099867
114MP0001819_abnormal_immune_cell0.95727002
115MP0003329_amyloid_beta_deposits0.94245958
116MP0003828_pulmonary_edema0.93569283
117MP0001835_abnormal_antigen_presentation0.92708090
118MP0005000_abnormal_immune_tolerance0.92382027
119MP0004885_abnormal_endolymph0.92370618
120MP0010630_abnormal_cardiac_muscle0.92146745
121MP0003045_fibrosis0.91649904
122MP0003385_abnormal_body_wall0.91457143
123MP0009931_abnormal_skin_appearance0.91334370
124MP0004134_abnormal_chest_morphology0.89702524
125MP0002019_abnormal_tumor_incidence0.88871433
126MP0000733_abnormal_muscle_development0.87880921
127MP0010030_abnormal_orbit_morphology0.87648479
128MP0000428_abnormal_craniofacial_morphol0.87504153
129MP0005075_abnormal_melanosome_morpholog0.87038331
130MP0002249_abnormal_larynx_morphology0.86265659
131MP0005621_abnormal_cell_physiology0.85042051
132MP0003448_altered_tumor_morphology0.83830354
133MP0010155_abnormal_intestine_physiology0.83536319
134MP0005384_cellular_phenotype0.81693926
135MP0002166_altered_tumor_susceptibility0.80256417
136MP0000751_myopathy0.79793231
137MP0002405_respiratory_system_inflammati0.79682567
138MP0005310_abnormal_salivary_gland0.78442221
139MP0003935_abnormal_craniofacial_develop0.78397158
140MP0002938_white_spotting0.78246283
141MP0008995_early_reproductive_senescence0.78024803
142MP0002009_preneoplasia0.77478170
143MP0005623_abnormal_meninges_morphology0.76618136
144MP0000747_muscle_weakness0.76551404
145MP0001851_eye_inflammation0.76312524
146MP0002723_abnormal_immune_serum0.75850631
147MP0002210_abnormal_sex_determination0.74747774
148MP0005023_abnormal_wound_healing0.74606831
149MP0002925_abnormal_cardiovascular_devel0.74281954
150MP0001145_abnormal_male_reproductive0.74252272
151MP0000759_abnormal_skeletal_muscle0.74085079
152MP0003632_abnormal_nervous_system0.72530346
153MP0002092_abnormal_eye_morphology0.71851734
154MP0001533_abnormal_skeleton_physiology0.70306537
155MP0001286_abnormal_eye_development0.70162861
156MP0000477_abnormal_intestine_morphology0.69970565
157MP0003119_abnormal_digestive_system0.68317016
158MP0001915_intracranial_hemorrhage0.66310232
159MP0003755_abnormal_palate_morphology0.65393586
160MP0003091_abnormal_cell_migration0.63898189

Predicted human phenotypes

RankGene SetZ-score
1Anterior segment dysgenesis (HP:0007700)8.18083178
2Cerebellar dysplasia (HP:0007033)8.07658777
3Prostate neoplasm (HP:0100787)7.90888912
4Bundle branch block (HP:0011710)6.65926464
5Buphthalmos (HP:0000557)5.90485245
6Ependymoma (HP:0002888)5.85177908
7Type II lissencephaly (HP:0007260)5.79238013
8Medulloblastoma (HP:0002885)5.12554734
9Agnosia (HP:0010524)5.00171599
10Astrocytoma (HP:0009592)4.13974060
11Abnormality of the astrocytes (HP:0100707)4.13974060
12Stomach cancer (HP:0012126)3.89932859
13Abnormality of the prostate (HP:0008775)3.80249498
14Spinal rigidity (HP:0003306)3.78350440
15Congenital glaucoma (HP:0001087)3.68370800
16Rhabdomyosarcoma (HP:0002859)3.62408830
17Glioma (HP:0009733)3.48878142
18Hyperacusis (HP:0010780)3.45583914
19Heart block (HP:0012722)3.42001705
20Abnormality of the anterior chamber (HP:0000593)3.38864227
21Broad face (HP:0000283)3.34301615
22Gastrointestinal stroma tumor (HP:0100723)3.33579151
23Acute lymphatic leukemia (HP:0006721)3.24221829
24Abnormal atrioventricular conduction (HP:0005150)3.22369728
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.98795709
26Amaurosis fugax (HP:0100576)2.94202029
27Cerebral aneurysm (HP:0004944)2.93883031
28Increased neuronal autofluorescent lipopigment (HP:0002074)2.92983063
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92626902
30Birth length less than 3rd percentile (HP:0003561)2.91554551
31Obstructive sleep apnea (HP:0002870)2.89722454
32Chromsome breakage (HP:0040012)2.88013935
33Increased connective tissue (HP:0009025)2.81517070
34Neoplasm of striated muscle (HP:0009728)2.68503831
35Biliary tract neoplasm (HP:0100574)2.68373493
36Ulnar bowing (HP:0003031)2.66780258
37Premature rupture of membranes (HP:0001788)2.66713595
38Hypoplasia of the brainstem (HP:0002365)2.66707132
39Aplasia/Hypoplasia of the brainstem (HP:0007362)2.66707132
40Protrusio acetabuli (HP:0003179)2.61720912
41Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.60343163
42Abnormal number of incisors (HP:0011064)2.54931176
43Basal cell carcinoma (HP:0002671)2.54239105
44Abnormality of the fingertips (HP:0001211)2.52531188
45Achilles tendon contracture (HP:0001771)2.51153172
46Disproportionate tall stature (HP:0001519)2.49951906
47Selective tooth agenesis (HP:0001592)2.48531410
48Agammaglobulinemia (HP:0004432)2.46505422
49Increased cerebral lipofuscin (HP:0011813)2.45861017
50Macroglossia (HP:0000158)2.44284596
51Flat acetabular roof (HP:0003180)2.43807459
52Meningocele (HP:0002435)2.43250318
53Generalized muscle weakness (HP:0003324)2.37973736
54Thin bony cortex (HP:0002753)2.37122223
55Long palpebral fissure (HP:0000637)2.36421715
56Eczematoid dermatitis (HP:0000976)2.33372301
57Shallow orbits (HP:0000586)2.32306623
58Severe muscular hypotonia (HP:0006829)2.30215555
59Neoplasm of the rectum (HP:0100743)2.27862461
60Atrophic scars (HP:0001075)2.27049763
61Centrally nucleated skeletal muscle fibers (HP:0003687)2.26873367
62Abnormality of the Achilles tendon (HP:0005109)2.24903196
63Malignant gastrointestinal tract tumors (HP:0006749)2.23894315
64Gastrointestinal carcinoma (HP:0002672)2.23894315
65Abnormality of the distal phalanx of the thumb (HP:0009617)2.22129844
66Abnormality of the pupil (HP:0000615)2.21907477
67Intellectual disability, profound (HP:0002187)2.20284357
68Fragile skin (HP:0001030)2.16793267
69Distal upper limb amyotrophy (HP:0007149)2.16760146
70Upper limb amyotrophy (HP:0009129)2.16760146
71Neuroblastoma (HP:0003006)2.14682842
72Primitive neuroectodermal tumor (HP:0030065)2.14682842
73Neuroblastic tumors (HP:0004376)2.14682842
74Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.14682842
75Chin dimple (HP:0010751)2.13141116
76Open mouth (HP:0000194)2.12417144
77Neoplasm of the small intestine (HP:0100833)2.11130518
78Persistence of primary teeth (HP:0006335)2.10772198
79Lissencephaly (HP:0001339)2.09248646
80Abnormality of the thoracic spine (HP:0100711)2.08645251
81Difficulty climbing stairs (HP:0003551)2.08028427
82Hemorrhage of the eye (HP:0011885)2.07764003
83Abnormality of male internal genitalia (HP:0000022)2.07571459
84Cervical subluxation (HP:0003308)2.05320623
85Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04641403
86Short 4th metacarpal (HP:0010044)2.04641403
87Long eyelashes (HP:0000527)2.00793737
88Distal lower limb muscle weakness (HP:0009053)1.98842244
89Dislocated radial head (HP:0003083)1.97951241
90Aneurysm (HP:0002617)1.97572013
91Premature skin wrinkling (HP:0100678)1.96402460
92Lower limb amyotrophy (HP:0007210)1.96271164
93Natal tooth (HP:0000695)1.96110677
94Mitral regurgitation (HP:0001653)1.94453367
95Advanced eruption of teeth (HP:0006288)1.93562158
96Genu recurvatum (HP:0002816)1.91807832
97Increased variability in muscle fiber diameter (HP:0003557)1.90818513
98Insomnia (HP:0100785)1.90399460
99Lymphoma (HP:0002665)1.89892879
10011 pairs of ribs (HP:0000878)1.89777777
101Mitral valve prolapse (HP:0001634)1.89604397
102Vertebral compression fractures (HP:0002953)1.88742963
103Dysmetric saccades (HP:0000641)1.88691887
104Non-midline cleft lip (HP:0100335)1.87967528
105Colitis (HP:0002583)1.86301761
106Blue sclerae (HP:0000592)1.84495240
107Segmental peripheral demyelination/remyelination (HP:0003481)1.84031076
108Thoracic kyphosis (HP:0002942)1.82197809
109Biconcave vertebral bodies (HP:0004586)1.81549255
110Acute myeloid leukemia (HP:0004808)1.80037297
111Abnormality of the radial head (HP:0003995)1.79283590
112Short nail (HP:0001799)1.78604762
113Stridor (HP:0010307)1.77841283
114Milia (HP:0001056)1.77334541
115Gingivitis (HP:0000230)1.74501557
116Increased IgE level (HP:0003212)1.74415041
117Freckling (HP:0001480)1.74412670
118Urethral obstruction (HP:0000796)1.73325681
119Dilatation of the ascending aorta (HP:0005111)1.73041578
120Cerebral inclusion bodies (HP:0100314)1.73011579
121Pointed chin (HP:0000307)1.72509109
122Abnormality of skeletal muscle fiber size (HP:0012084)1.72503730
123Mildly elevated creatine phosphokinase (HP:0008180)1.70045231
124Deep venous thrombosis (HP:0002625)1.69066633
125Prominent nose (HP:0000448)1.67865826
126Polygenic inheritance (HP:0010982)1.67559572
127Deep palmar crease (HP:0006191)1.67151754
128Syringomyelia (HP:0003396)1.66925278
129Spinal cord lesions (HP:0100561)1.66925278
130Ankyloglossia (HP:0010296)1.66858079
131Aplastic anemia (HP:0001915)1.66395032
132Proximal placement of thumb (HP:0009623)1.66377151
133Ectopic kidney (HP:0000086)1.65836598
134Abnormality of the distal phalanges of the toes (HP:0010182)1.65041960
135Interstitial pulmonary disease (HP:0006530)1.63592807
136Panhypogammaglobulinemia (HP:0003139)1.63380856
137Abnormal ossification of hand bones (HP:0005921)1.63310462
138Osteolytic defects of the hand bones (HP:0009699)1.61858700
139Osteolytic defects of the phalanges of the hand (HP:0009771)1.61858700
140Thin ribs (HP:0000883)1.61568418
141Joint laxity (HP:0001388)1.61322961
142Bronchomalacia (HP:0002780)1.60700526
143Muscular dystrophy (HP:0003560)1.60572099
144Bladder diverticulum (HP:0000015)1.60239316
145Abnormality of oral frenula (HP:0000190)1.60200582
146Deviation of the thumb (HP:0009603)1.60033744
147Myocardial infarction (HP:0001658)1.59857732
148Easy fatigability (HP:0003388)1.59231208
149Missing ribs (HP:0000921)1.58609202
150Optic nerve coloboma (HP:0000588)1.58294968
151Wormian bones (HP:0002645)1.58246957
152Hypoplasia of the iris (HP:0007676)1.57818440
153Malignant neoplasm of the central nervous system (HP:0100836)1.57135433
154Abnormality of chromosome stability (HP:0003220)1.57110456
155Onion bulb formation (HP:0003383)1.57064835
156Metaphyseal cupping (HP:0003021)1.56920877
157Aplasia/Hypoplasia of the uvula (HP:0010293)1.56650378
158Neoplasm of the colon (HP:0100273)1.56453197
159Emphysema (HP:0002097)1.56354516
160Patellar dislocation (HP:0002999)1.56345142
161Neoplasm of the pancreas (HP:0002894)1.56326774
162Hypoplastic ischia (HP:0003175)1.56259171
163Neuroectodermal neoplasm (HP:0030061)1.55579189
164Neuroepithelial neoplasm (HP:0030063)1.55579189
165Nervous tissue neoplasm (HP:0030060)1.55579189
166Benign neoplasm of the central nervous system (HP:0100835)1.54849081
167Asymmetry of the thorax (HP:0001555)1.53763773
168Leukopenia (HP:0001882)1.53145138
169Arnold-Chiari malformation (HP:0002308)1.52249082
170Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.52218378
171Gastrointestinal inflammation (HP:0004386)1.52071329
172Neoplasm of the oral cavity (HP:0100649)1.51953109
173Broad thumb (HP:0011304)1.51751756
174Lymphopenia (HP:0001888)1.51369579
175Vertebral arch anomaly (HP:0008438)1.51206367
176Skull defect (HP:0001362)1.50927560
177Abnormal biliary tract morphology (HP:0012440)1.50918045
178Broad distal phalanx of finger (HP:0009836)1.50067087
179Bicuspid aortic valve (HP:0001647)1.49700340
180Precocious puberty (HP:0000826)1.49124530
181Meckel diverticulum (HP:0002245)1.49077307
182Abnormal delayed hypersensitivity skin test (HP:0002963)1.48421321
183Sparse lateral eyebrow (HP:0005338)1.48253284
184Ankle contracture (HP:0006466)1.48059669
185Cellulitis (HP:0100658)1.47783432
186Trismus (HP:0000211)1.47780122
187Abnormality of cells of the lymphoid lineage (HP:0012140)1.47530060
188Abnormality of the vitreous humor (HP:0004327)1.46848996
189Bowing of the arm (HP:0006488)1.46385474
190Bowed forearm bones (HP:0003956)1.46385474
191Distal lower limb amyotrophy (HP:0008944)1.43260110
192Supernumerary ribs (HP:0005815)1.42415667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.11252598
2SMG13.65824264
3FLT33.22811691
4KIT2.94853408
5MAP3K142.86142480
6SIK12.86043113
7ERN12.60803165
8CDK122.32400355
9RIPK12.20510694
10CLK12.06016139
11PIK3CG12.0055484
12FGFR41.99031439
13PIK3CA1.98282166
14PDGFRA1.58354867
15BRD41.56839926
16MATK1.46307982
17CDC71.45664758
18TAOK21.41293326
19MAP3K131.40528382
20TAOK11.36185535
21CSF1R1.30384557
22CAMK1D1.30163619
23MARK21.27623514
24CDC42BPA1.26014290
25MST1R1.21986064
26MKNK21.20632855
27NME21.17476946
28MKNK11.12203051
29NEK21.11824598
30PRPF4B1.09637014
31MAP3K31.07069849
32EEF2K1.03344270
33CHEK11.00376278
34RIPK40.99014349
35PASK0.97291637
36MAP3K110.96629106
37CHUK0.96298989
38PLK10.95303765
39RPS6KA20.93068380
40CDK70.92734508
41TSSK60.91271051
42STK100.89991463
43TTK0.89844139
44SRPK10.89566841
45TBK10.88659879
46ICK0.88459770
47MAP4K10.88176590
48MAP3K10.87964691
49PLK40.81848749
50ATR0.80361123
51PRKD20.79019433
52CAMK1G0.77910022
53ALK0.77736586
54BMX0.77144375
55LATS20.76711189
56MAPK110.75159994
57MAP3K60.75016428
58ZAP700.74317773
59IRAK20.73566246
60DDR20.73328614
61KSR20.71284771
62STK40.70541573
63HIPK20.70509565
64EPHA20.70364929
65TGFBR10.69290437
66PDGFRB0.69015447
67PDPK10.68764404
68RPS6KB20.68598461
69ARAF0.68080130
70ATM0.67688597
71MAP2K30.67415373
72IRAK40.67046933
73WEE10.66877671
74TNK20.66011279
75TESK20.64337101
76TYRO30.63999489
77LMTK20.63022202
78PRKD30.61988331
79MAPK70.60589955
80CDK60.60085401
81YES10.59124771
82FGFR30.59121125
83CDK40.57425975
84GRK60.57365351
85CSK0.57180997
86MAP3K70.57018185
87MTOR0.56875488
88EPHB10.55795519
89IRAK30.55398634
90LCK0.54966779
91PAK40.54710590
92CDK90.53885170
93SIK30.52673501
94JAK10.51023929
95FGR0.49724061
96BRAF0.49082044
97PIM10.48035488
98BUB10.47965054
99CDK20.47802876
100SGK30.46823031
101PLK30.46398509
102MET0.46376859
103PTK60.46354007
104PNCK0.45903102
105TESK10.45845857
106PIM20.45827143
107MELK0.44454875
108ZAK0.43960980
109SIK20.43805488
110TRIB30.43264893
111RPS6KL10.42600388
112RPS6KC10.42600388
113PDK10.41547707
114PKN20.40894476
115RPS6KA40.40262923
116MAPK120.39739452
117RPS6KA10.39376360
118STK30.39208728
119MAP3K80.37938585
120DYRK30.37798037
121MAP2K20.37699758
122RPS6KA60.37600369
123CHEK20.37523418
124LRRK20.36864533
125CSNK1E0.36717674
126HCK0.36319621
127BTK0.36119018
128TRPM70.35812913
129CDK10.35701026
130DYRK1B0.34525199
131PRKDC0.33587259
132CCNB10.33560761
133MAPKAPK20.32804948
134IKBKE0.32393535
135AKT10.30958552
136JAK30.28913927
137RET0.28157042
138CSNK2A20.27816777
139AURKB0.26475587
140IKBKB0.26107120
141BLK0.25133251
142PRKCH0.24771645
143PAK20.24166535
144MAPK140.24022769
145TYK20.23721503
146EIF2AK20.23659441
147RPS6KA50.22444803
148TXK0.22248978
149TTN0.22050603
150PTK20.21955303
151MAPK10.21814797
152PRKD10.21053656
153MAPK30.20180296
154BRSK20.20149974
155PRKG10.19948983
156CSNK1D0.19920433
157RPS6KB10.19393788

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.12479648
2Acute myeloid leukemia_Homo sapiens_hsa052212.54584746
3Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.33882574
4Other glycan degradation_Homo sapiens_hsa005112.23180807
5Fanconi anemia pathway_Homo sapiens_hsa034602.18236742
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14159951
7Spliceosome_Homo sapiens_hsa030402.10628304
8B cell receptor signaling pathway_Homo sapiens_hsa046622.08816118
9DNA replication_Homo sapiens_hsa030302.02639292
10mRNA surveillance pathway_Homo sapiens_hsa030151.94413337
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.93600806
12Endometrial cancer_Homo sapiens_hsa052131.91781381
13Central carbon metabolism in cancer_Homo sapiens_hsa052301.87464633
14Non-small cell lung cancer_Homo sapiens_hsa052231.85550375
15Small cell lung cancer_Homo sapiens_hsa052221.71430877
16Cell cycle_Homo sapiens_hsa041101.67730042
17Colorectal cancer_Homo sapiens_hsa052101.66461162
18RNA transport_Homo sapiens_hsa030131.64531535
19Chronic myeloid leukemia_Homo sapiens_hsa052201.62359333
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.62039854
21Bladder cancer_Homo sapiens_hsa052191.61170452
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55604310
23Type II diabetes mellitus_Homo sapiens_hsa049301.53605323
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.51784628
25One carbon pool by folate_Homo sapiens_hsa006701.50582461
26mTOR signaling pathway_Homo sapiens_hsa041501.42764310
27T cell receptor signaling pathway_Homo sapiens_hsa046601.40995064
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40258396
29Prostate cancer_Homo sapiens_hsa052151.39033223
30Pancreatic cancer_Homo sapiens_hsa052121.38773948
31Non-homologous end-joining_Homo sapiens_hsa034501.37195057
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36322797
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35127009
34Prion diseases_Homo sapiens_hsa050201.31085663
35Viral carcinogenesis_Homo sapiens_hsa052031.29288441
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28570037
37Measles_Homo sapiens_hsa051621.28429068
38Prolactin signaling pathway_Homo sapiens_hsa049171.24994789
39Glioma_Homo sapiens_hsa052141.22676718
40Primary immunodeficiency_Homo sapiens_hsa053401.22151916
41Renal cell carcinoma_Homo sapiens_hsa052111.21853446
42VEGF signaling pathway_Homo sapiens_hsa043701.21170897
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20584772
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20004559
45Melanoma_Homo sapiens_hsa052181.19797213
46Epstein-Barr virus infection_Homo sapiens_hsa051691.19225999
47Base excision repair_Homo sapiens_hsa034101.19206890
48Homologous recombination_Homo sapiens_hsa034401.18571066
49HTLV-I infection_Homo sapiens_hsa051661.17400354
50Osteoclast differentiation_Homo sapiens_hsa043801.15234381
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14384143
52Inositol phosphate metabolism_Homo sapiens_hsa005621.10912699
53Insulin signaling pathway_Homo sapiens_hsa049101.09623086
54Lysine degradation_Homo sapiens_hsa003101.06845019
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.04133632
56Fructose and mannose metabolism_Homo sapiens_hsa000511.02932596
57Pentose phosphate pathway_Homo sapiens_hsa000301.02304594
58Toxoplasmosis_Homo sapiens_hsa051451.01510476
59Apoptosis_Homo sapiens_hsa042101.01497496
60Adherens junction_Homo sapiens_hsa045201.00196108
61Leishmaniasis_Homo sapiens_hsa051400.99536902
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98223149
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.98197695
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97800142
65Nucleotide excision repair_Homo sapiens_hsa034200.97022143
66Basal transcription factors_Homo sapiens_hsa030220.96311867
67GnRH signaling pathway_Homo sapiens_hsa049120.95660378
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.95225913
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93321694
70MicroRNAs in cancer_Homo sapiens_hsa052060.93196320
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92371397
72Hepatitis B_Homo sapiens_hsa051610.91837637
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91716867
74Notch signaling pathway_Homo sapiens_hsa043300.90399704
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89491523
76TNF signaling pathway_Homo sapiens_hsa046680.89409012
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.89363596
78Influenza A_Homo sapiens_hsa051640.88757819
79RNA degradation_Homo sapiens_hsa030180.88433316
80Shigellosis_Homo sapiens_hsa051310.87151926
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.85960499
82Galactose metabolism_Homo sapiens_hsa000520.83494174
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82988236
84Salmonella infection_Homo sapiens_hsa051320.81403426
85HIF-1 signaling pathway_Homo sapiens_hsa040660.81080036
86ErbB signaling pathway_Homo sapiens_hsa040120.81055448
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.80553863
88Choline metabolism in cancer_Homo sapiens_hsa052310.80502155
89Platelet activation_Homo sapiens_hsa046110.80474698
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80388348
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80231766
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.80013204
93p53 signaling pathway_Homo sapiens_hsa041150.79995727
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79240179
95FoxO signaling pathway_Homo sapiens_hsa040680.79003509
96Insulin resistance_Homo sapiens_hsa049310.78731218
97Ribosome_Homo sapiens_hsa030100.77679804
98RNA polymerase_Homo sapiens_hsa030200.76753113
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.75547332
100Tuberculosis_Homo sapiens_hsa051520.74912899
101Estrogen signaling pathway_Homo sapiens_hsa049150.74646924
102Amoebiasis_Homo sapiens_hsa051460.74521172
103Herpes simplex infection_Homo sapiens_hsa051680.74312990
104Antigen processing and presentation_Homo sapiens_hsa046120.74003546
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72735851
106Endocytosis_Homo sapiens_hsa041440.71020949
107ECM-receptor interaction_Homo sapiens_hsa045120.70608112
108Malaria_Homo sapiens_hsa051440.69696449
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.69257470
110Pathways in cancer_Homo sapiens_hsa052000.68779215
111Hematopoietic cell lineage_Homo sapiens_hsa046400.68665062
112Hepatitis C_Homo sapiens_hsa051600.68562977
113Selenocompound metabolism_Homo sapiens_hsa004500.65687638
114Proteoglycans in cancer_Homo sapiens_hsa052050.63724670
115Basal cell carcinoma_Homo sapiens_hsa052170.63264233
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62649729
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60815607
118Chemokine signaling pathway_Homo sapiens_hsa040620.59697142
119Lysosome_Homo sapiens_hsa041420.58504403
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57536460
121Rap1 signaling pathway_Homo sapiens_hsa040150.56784584
122Thyroid cancer_Homo sapiens_hsa052160.56407216
123Biosynthesis of amino acids_Homo sapiens_hsa012300.54628638
124MAPK signaling pathway_Homo sapiens_hsa040100.53977069
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52896188
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52420081
127Pertussis_Homo sapiens_hsa051330.52327027
128Focal adhesion_Homo sapiens_hsa045100.52038947
129AMPK signaling pathway_Homo sapiens_hsa041520.48418024
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48369411
131Viral myocarditis_Homo sapiens_hsa054160.47648965
132Pyrimidine metabolism_Homo sapiens_hsa002400.46435502
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45104703

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