PHTF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)6.59151758
2muscle filament sliding (GO:0030049)6.59151758
3regulation of skeletal muscle contraction (GO:0014819)5.64763161
4actin-mediated cell contraction (GO:0070252)5.64688686
5sarcomere organization (GO:0045214)5.40619064
6sarcoplasmic reticulum calcium ion transport (GO:0070296)5.13235497
7myofibril assembly (GO:0030239)5.01241501
8cardiac myofibril assembly (GO:0055003)4.97848869
9inositol phosphate catabolic process (GO:0071545)4.71677941
10inositol phosphate dephosphorylation (GO:0046855)4.62207060
11phosphorylated carbohydrate dephosphorylation (GO:0046838)4.62207060
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.55624338
13regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.54164218
14actin filament-based movement (GO:0030048)4.38864247
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.26898545
16protein K6-linked ubiquitination (GO:0085020)4.25854204
17skeletal muscle contraction (GO:0003009)4.25486618
18mitotic chromosome condensation (GO:0007076)4.24016921
19IMP metabolic process (GO:0046040)4.17330585
20regulation of hexokinase activity (GO:1903299)4.10801577
21regulation of glucokinase activity (GO:0033131)4.10801577
22regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.08159216
23regulation of acyl-CoA biosynthetic process (GO:0050812)4.02973986
24regulation of relaxation of muscle (GO:1901077)4.01233468
25negative regulation of potassium ion transmembrane transport (GO:1901380)3.93793494
26cardiac muscle cell development (GO:0055013)3.92843538
27IMP biosynthetic process (GO:0006188)3.91410925
28striated muscle contraction (GO:0006941)3.89265097
29plasma membrane repair (GO:0001778)3.84632664
30glycogen catabolic process (GO:0005980)3.78730599
31regulation of meiosis I (GO:0060631)3.78242102
32synapsis (GO:0007129)3.77684011
33mitotic sister chromatid cohesion (GO:0007064)3.76224767
34protein targeting to Golgi (GO:0000042)3.74729209
35regulation of coenzyme metabolic process (GO:0051196)3.72136938
36regulation of cofactor metabolic process (GO:0051193)3.72136938
37cardiac cell development (GO:0055006)3.71389541
38regulation of cell communication by electrical coupling (GO:0010649)3.70190540
39skeletal muscle adaptation (GO:0043501)3.68227919
40cardiac muscle contraction (GO:0060048)3.66017801
41establishment of protein localization to Golgi (GO:0072600)3.64674091
42glucan biosynthetic process (GO:0009250)3.58353278
43glycogen biosynthetic process (GO:0005978)3.58353278
44mitotic metaphase plate congression (GO:0007080)3.56956183
45positive regulation of meiosis (GO:0045836)3.56437446
46regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.54421078
47protein localization to kinetochore (GO:0034501)3.54395480
48nuclear pore complex assembly (GO:0051292)3.52781833
49retrograde transport, vesicle recycling within Golgi (GO:0000301)3.49400042
50tricarboxylic acid cycle (GO:0006099)3.48060613
51cardiac muscle hypertrophy (GO:0003300)3.47301816
52actomyosin structure organization (GO:0031032)3.47271330
53meiotic chromosome segregation (GO:0045132)3.44910994
54regulation of sarcomere organization (GO:0060297)3.42143889
55heart process (GO:0003015)3.41526172
56heart contraction (GO:0060047)3.41526172
57positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.41153947
58glucan catabolic process (GO:0009251)3.40639683
59regulation of energy homeostasis (GO:2000505)3.39218580
60response to muscle activity (GO:0014850)3.37447787
61striated muscle hypertrophy (GO:0014897)3.34679874
62nuclear pore organization (GO:0006999)3.34079328
63polyketide metabolic process (GO:0030638)3.33885090
64doxorubicin metabolic process (GO:0044598)3.33885090
65daunorubicin metabolic process (GO:0044597)3.33885090
66polyol catabolic process (GO:0046174)3.33433492
67negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.31987334
68response to inactivity (GO:0014854)3.30747113
69carnitine shuttle (GO:0006853)3.30504953
70positive regulation of meiotic cell cycle (GO:0051446)3.26896001
71piRNA metabolic process (GO:0034587)3.24650661
72attachment of spindle microtubules to kinetochore (GO:0008608)3.22200444
73metaphase plate congression (GO:0051310)3.20581425
74regulation of spindle organization (GO:0090224)3.13771230
75cellular polysaccharide catabolic process (GO:0044247)3.11599408
76regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.07229934
77protein localization to chromosome, centromeric region (GO:0071459)3.05144502
78negative regulation of meiosis (GO:0045835)3.04406054
79regulation of sulfur metabolic process (GO:0042762)3.03045428
80skeletal muscle tissue regeneration (GO:0043403)3.02360141
81negative regulation of execution phase of apoptosis (GO:1900118)3.01700874
82lactate metabolic process (GO:0006089)2.98525542
83cytidine deamination (GO:0009972)2.96736584
84cytidine metabolic process (GO:0046087)2.96736584
85cytidine catabolic process (GO:0006216)2.96736584
86phosphatidylinositol dephosphorylation (GO:0046856)2.96611160
87regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.95668697
88phospholipid dephosphorylation (GO:0046839)2.95649355
89regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.94531285
90regulation of DNA endoreduplication (GO:0032875)2.94162933
91muscle hypertrophy (GO:0014896)2.93856282
92regulation of skeletal muscle cell differentiation (GO:2001014)2.93653081
93monoubiquitinated protein deubiquitination (GO:0035520)2.91748563
94Golgi to endosome transport (GO:0006895)2.91313746
95cardiac muscle tissue morphogenesis (GO:0055008)2.91025460
96negative regulation of histone methylation (GO:0031061)2.88041418
97positive regulation of glycolytic process (GO:0045821)2.87910201
98striated muscle adaptation (GO:0014888)2.87271416
99intra-Golgi vesicle-mediated transport (GO:0006891)2.84661659
100response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.83169970
101establishment of chromosome localization (GO:0051303)2.81651275
102myotube cell development (GO:0014904)2.81368116
103pore complex assembly (GO:0046931)2.79758808
104skeletal muscle fiber development (GO:0048741)2.79394044
105skeletal muscle tissue development (GO:0007519)2.78415885
106mitotic nuclear envelope disassembly (GO:0007077)2.78354140
107regulation of actin filament-based movement (GO:1903115)2.78089961
108macroautophagy (GO:0016236)2.77750065
109polysaccharide catabolic process (GO:0000272)2.76987238
110positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76466035
111positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76466035
112positive regulation of mitotic sister chromatid separation (GO:1901970)2.76466035
113muscle cell cellular homeostasis (GO:0046716)2.74182829
114regulation of protein glycosylation (GO:0060049)2.74174071
115N-terminal protein amino acid acetylation (GO:0006474)2.73570558
116spindle checkpoint (GO:0031577)2.72503468
117regulation of Rac protein signal transduction (GO:0035020)2.72027384
118negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.70721943
119kinetochore organization (GO:0051383)2.70347119
120paraxial mesoderm development (GO:0048339)2.69890545
121muscle system process (GO:0003012)2.69518851
122striated muscle cell development (GO:0055002)2.69236339
123muscle fiber development (GO:0048747)2.69163278
124COPII vesicle coating (GO:0048208)2.68543033
125muscle tissue morphogenesis (GO:0060415)2.67962168
126muscle contraction (GO:0006936)2.67447189
127positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.66609394
128positive regulation of histone H3-K4 methylation (GO:0051571)2.66601856
129DNA replication-independent nucleosome assembly (GO:0006336)2.65621590
130DNA replication-independent nucleosome organization (GO:0034724)2.65621590
131fatty acid transmembrane transport (GO:1902001)2.65008790
132endoplasmic reticulum organization (GO:0007029)2.64121844
133regulation of mitotic spindle organization (GO:0060236)2.62494371
134nuclear envelope disassembly (GO:0051081)2.62265150
135membrane disassembly (GO:0030397)2.62265150
136magnesium ion transport (GO:0015693)2.61851871
137regulation of calcium ion import (GO:0090279)2.61550820
138fibroblast migration (GO:0010761)2.60969766
139DNA demethylation (GO:0080111)2.60644032
140adult heart development (GO:0007512)2.60360305
141protein K11-linked deubiquitination (GO:0035871)2.59820208
142protein localization to chromosome (GO:0034502)2.59385108
143sister chromatid cohesion (GO:0007062)2.58781308
144cardiac muscle hypertrophy in response to stress (GO:0014898)2.58287319
145muscle hypertrophy in response to stress (GO:0003299)2.58287319
146cardiac muscle adaptation (GO:0014887)2.58287319
147DNA replication checkpoint (GO:0000076)2.57888576
148interkinetic nuclear migration (GO:0022027)2.55890657
149glycogen metabolic process (GO:0005977)2.55815259
150spindle assembly checkpoint (GO:0071173)2.55570309
151pyrimidine ribonucleoside catabolic process (GO:0046133)2.55557137
152resolution of meiotic recombination intermediates (GO:0000712)2.55519345
153CENP-A containing nucleosome assembly (GO:0034080)2.55512045
154regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.53301429
155regulation of mitotic metaphase/anaphase transition (GO:0030071)2.53270956
156G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.53061709
157lipid particle organization (GO:0034389)2.51393547
158succinate metabolic process (GO:0006105)2.50716723
159positive regulation of gluconeogenesis (GO:0045722)2.48502924
160muscle organ morphogenesis (GO:0048644)2.46194767
161cellular glucan metabolic process (GO:0006073)2.45801724
162glucan metabolic process (GO:0044042)2.45801724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.67723358
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.33953064
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.01373746
4* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.34408254
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.21072822
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10129931
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.07571584
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.85176087
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.78898804
10IGF1R_20145208_ChIP-Seq_DFB_Human2.77725420
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.72738861
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.65952919
13GBX2_23144817_ChIP-Seq_PC3_Human2.56386967
14AR_21909140_ChIP-Seq_LNCAP_Human2.37277038
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.33765067
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29744428
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.29180612
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27289927
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25657887
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19470147
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.19143461
22YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.18592090
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08714001
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07648782
25TP63_19390658_ChIP-ChIP_HaCaT_Human2.05746763
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05717751
27CIITA_25753668_ChIP-Seq_RAJI_Human2.03493728
28MYC_22102868_ChIP-Seq_BL_Human2.01819213
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99459934
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.93585848
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92074364
32* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91335997
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.88476572
34ER_23166858_ChIP-Seq_MCF-7_Human1.86997187
35TAF15_26573619_Chip-Seq_HEK293_Human1.86062186
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82562044
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.81683739
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79130509
39* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75195951
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74195516
41MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.73945575
42* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.73874732
43ZNF274_21170338_ChIP-Seq_K562_Hela1.73357010
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.72476468
45SMAD4_21799915_ChIP-Seq_A2780_Human1.69463750
46* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68922038
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.68503170
48GATA4_21415370_ChIP-Seq_HL-1_Mouse1.67922096
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64090094
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.62423894
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.62396339
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60684829
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.59601405
54* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59169482
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58637884
56VDR_22108803_ChIP-Seq_LS180_Human1.58628878
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57828061
58STAT3_23295773_ChIP-Seq_U87_Human1.57658218
59HTT_18923047_ChIP-ChIP_STHdh_Human1.56743647
60TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.55700356
61CRX_20693478_ChIP-Seq_RETINA_Mouse1.54900638
62* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54626511
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54168313
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.53895429
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.53370867
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52019656
67ELK1_19687146_ChIP-ChIP_HELA_Human1.51720425
68P300_19829295_ChIP-Seq_ESCs_Human1.50640401
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.49240038
70VDR_23849224_ChIP-Seq_CD4+_Human1.49150549
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49093443
72NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.49093425
73ZNF263_19887448_ChIP-Seq_K562_Human1.48300431
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47895059
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46874625
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46794997
77P53_22387025_ChIP-Seq_ESCs_Mouse1.45503390
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.45292416
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44068166
80EST1_17652178_ChIP-ChIP_JURKAT_Human1.43977148
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43595071
82KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41594957
83* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40765790
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39312475
85OCT4_21477851_ChIP-Seq_ESCs_Mouse1.36728750
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36600601
87* TCF4_23295773_ChIP-Seq_U87_Human1.36344236
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35149772
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33894091
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.33116062
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.32326150
92SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.31132249
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30055019
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29244643
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27935113
96SOX2_18555785_Chip-Seq_ESCs_Mouse1.27315742
97OCT4_18555785_Chip-Seq_ESCs_Mouse1.26857617
98CDX2_22108803_ChIP-Seq_LS180_Human1.26745580
99ETS1_20019798_ChIP-Seq_JURKAT_Human1.26656787
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.25246154
101AR_25329375_ChIP-Seq_VCAP_Human1.25119501
102NMYC_18555785_Chip-Seq_ESCs_Mouse1.24990726
103FOXP3_21729870_ChIP-Seq_TREG_Human1.24570573
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.22668065
105* BRD4_25478319_ChIP-Seq_HGPS_Human1.22485783
106* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22053601
107* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21355168
108PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20616443
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.19882173
110P300_18555785_Chip-Seq_ESCs_Mouse1.19266609
111MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19185561
112KDM5A_27292631_Chip-Seq_BREAST_Human1.18960792
113CBP_20019798_ChIP-Seq_JUKART_Human1.18307280
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18307280
115* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17545803
116* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17052083
117* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17052083
118NANOG_21062744_ChIP-ChIP_HESCs_Human1.16637525
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16135041
120* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15713921
121* SMAD3_21741376_ChIP-Seq_EPCs_Human1.14489689
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14196070
123STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13557977
124GABP_17652178_ChIP-ChIP_JURKAT_Human1.13199299
125CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12989412
126ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12658450
127TFEB_21752829_ChIP-Seq_HELA_Human1.11448316
128TBX20_22328084_ChIP-Seq_HEART_Mouse1.10574009
129TBX20_22080862_ChIP-Seq_HEART_Mouse1.10574009
130CTCF_18555785_Chip-Seq_ESCs_Mouse1.10223313
131SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08420632
132POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08202393
133DCP1A_22483619_ChIP-Seq_HELA_Human1.07615402
134ZFX_18555785_Chip-Seq_ESCs_Mouse1.07472183
135STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07265923
136KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06249432
137TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06053746
138* BCAT_22108803_ChIP-Seq_LS180_Human1.04942086
139GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04808413
140GATA1_22025678_ChIP-Seq_K562_Human1.03581394
141PU1_27457419_Chip-Seq_LIVER_Mouse1.02933350
142* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02805114
143KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01629285
144SOX2_19829295_ChIP-Seq_ESCs_Human1.01192833
145NANOG_19829295_ChIP-Seq_ESCs_Human1.01192833
146RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00890872
147SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99646495
148HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99377253
149FLI1_27457419_Chip-Seq_LIVER_Mouse0.98730249
150EP300_21415370_ChIP-Seq_HL-1_Mouse0.97990062
151CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97408476
152TTF2_22483619_ChIP-Seq_HELA_Human0.97354090
153* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96399173
154THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95620692
155TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94224090
156TCF7_22412390_ChIP-Seq_EML_Mouse0.91519762
157XRN2_22483619_ChIP-Seq_HELA_Human0.91341963
158SRF_21415370_ChIP-Seq_HL-1_Mouse0.89048786
159ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87711572
160CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87608225
161ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87373472
162NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86237009
163* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86136006
164GABP_19822575_ChIP-Seq_HepG2_Human0.84844920
165* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84576443
166E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83101494
167* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80506951
168EWS_26573619_Chip-Seq_HEK293_Human0.80306287
169JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.79502288
170FUS_26573619_Chip-Seq_HEK293_Human0.78125697
171SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.77105172
172SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74191783
173GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72551876
174FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.71823192
175FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.71331117
176DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.70882343
177POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.70168738
178YY1_21170310_ChIP-Seq_MESCs_Mouse0.69916314
179* NANOG_16153702_ChIP-ChIP_HESCs_Human0.69700293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.23387272
2MP0004084_abnormal_cardiac_muscle4.10573123
3MP0000751_myopathy3.98398463
4MP0004145_abnormal_muscle_electrophysio3.85227859
5MP0000749_muscle_degeneration3.78541637
6MP0004036_abnormal_muscle_relaxation3.50006343
7MP0002837_dystrophic_cardiac_calcinosis3.40204544
8MP0004215_abnormal_myocardial_fiber2.94839423
9MP0000013_abnormal_adipose_tissue2.85164338
10MP0002106_abnormal_muscle_physiology2.81009504
11MP0009780_abnormal_chondrocyte_physiolo2.79836946
12MP0004087_abnormal_muscle_fiber2.61397784
13MP0005620_abnormal_muscle_contractility2.38530928
14MP0005330_cardiomyopathy2.38388083
15MP0008057_abnormal_DNA_replication2.38345479
16MP0000750_abnormal_muscle_regeneration2.37389708
17MP0010094_abnormal_chromosome_stability2.31185834
18MP0003221_abnormal_cardiomyocyte_apopto2.26417138
19MP0002269_muscular_atrophy2.15907814
20MP0005369_muscle_phenotype2.15871398
21MP0000759_abnormal_skeletal_muscle2.13924039
22MP0000747_muscle_weakness2.08309990
23MP0008877_abnormal_DNA_methylation2.05184166
24MP0003077_abnormal_cell_cycle2.04746363
25MP0008775_abnormal_heart_ventricle1.98212525
26MP0002972_abnormal_cardiac_muscle1.97418213
27MP0004130_abnormal_muscle_cell1.96187577
28MP0010630_abnormal_cardiac_muscle1.94665431
29MP0003111_abnormal_nucleus_morphology1.90771438
30MP0002009_preneoplasia1.83167835
31MP0010234_abnormal_vibrissa_follicle1.82731987
32MP0004233_abnormal_muscle_weight1.79495445
33MP0004484_altered_response_of1.78981652
34MP0005379_endocrine/exocrine_gland_phen1.75265963
35MP0003693_abnormal_embryo_hatching1.71614861
36MP0003828_pulmonary_edema1.70130871
37MP0008007_abnormal_cellular_replicative1.67452358
38MP0001544_abnormal_cardiovascular_syste1.67222501
39MP0005385_cardiovascular_system_phenoty1.67222501
40MP0000372_irregular_coat_pigmentation1.61666033
41MP0000733_abnormal_muscle_development1.59936502
42MP0003567_abnormal_fetal_cardiomyocyte1.57183515
43MP0004510_myositis1.49666554
44MP0008058_abnormal_DNA_repair1.49635811
45MP0000427_abnormal_hair_cycle1.49100084
46MP0002396_abnormal_hematopoietic_system1.39075253
47MP0004957_abnormal_blastocyst_morpholog1.38413899
48MP0006138_congestive_heart_failure1.37428168
49MP0002877_abnormal_melanocyte_morpholog1.34678481
50MP0002163_abnormal_gland_morphology1.33729534
51MP0003045_fibrosis1.32632470
52MP0003984_embryonic_growth_retardation1.31879799
53MP0002127_abnormal_cardiovascular_syste1.31269318
54MP0003137_abnormal_impulse_conducting1.30764020
55MP0001661_extended_life_span1.30081254
56MP0002332_abnormal_exercise_endurance1.29978526
57MP0004270_analgesia1.29149792
58MP0006036_abnormal_mitochondrial_physio1.29035045
59MP0002088_abnormal_embryonic_growth/wei1.27916815
60MP0000350_abnormal_cell_proliferation1.27680998
61MP0006072_abnormal_retinal_apoptosis1.26108039
62MP0004185_abnormal_adipocyte_glucose1.24611496
63MP0001672_abnormal_embryogenesis/_devel1.22674636
64MP0005380_embryogenesis_phenotype1.22674636
65MP0004808_abnormal_hematopoietic_stem1.16899219
66MP0000003_abnormal_adipose_tissue1.14717984
67MP0002693_abnormal_pancreas_physiology1.13330537
68MP0005645_abnormal_hypothalamus_physiol1.12792646
69MP0004134_abnormal_chest_morphology1.12467259
70MP0003950_abnormal_plasma_membrane1.11528016
71MP0000266_abnormal_heart_morphology1.10288952
72MP0005451_abnormal_body_composition1.08892677
73MP0001299_abnormal_eye_distance/1.08527000
74MP0001730_embryonic_growth_arrest1.08067856
75MP0003786_premature_aging1.07749030
76MP0003123_paternal_imprinting1.03169547
77MP0002971_abnormal_brown_adipose1.02148610
78MP0001697_abnormal_embryo_size0.96480313
79MP0002876_abnormal_thyroid_physiology0.96047580
80MP0000015_abnormal_ear_pigmentation0.91779042
81MP0006035_abnormal_mitochondrial_morpho0.91669563
82MP0010352_gastrointestinal_tract_polyps0.91147170
83MP0005666_abnormal_adipose_tissue0.90967875
84MP0003656_abnormal_erythrocyte_physiolo0.90676640
85MP0003890_abnormal_embryonic-extraembry0.89612548
86MP0002909_abnormal_adrenal_gland0.88871622
87MP0003787_abnormal_imprinting0.87831782
88MP0004197_abnormal_fetal_growth/weight/0.87806528
89MP0003763_abnormal_thymus_physiology0.87585877
90MP0003121_genomic_imprinting0.86511798
91MP0010307_abnormal_tumor_latency0.86507172
92MP0004085_abnormal_heartbeat0.86030082
93MP0002078_abnormal_glucose_homeostasis0.85969427
94MP0001944_abnormal_pancreas_morphology0.84987306
95MP0009697_abnormal_copulation0.84981992
96MP0002177_abnormal_outer_ear0.84735286
97MP0005076_abnormal_cell_differentiation0.82376378
98MP0010678_abnormal_skin_adnexa0.80752979
99MP0002166_altered_tumor_susceptibility0.79169581
100MP0008438_abnormal_cutaneous_collagen0.79124386
101MP0005266_abnormal_metabolism0.78386702
102MP0002168_other_aberrant_phenotype0.78131205
103MP0002086_abnormal_extraembryonic_tissu0.77234992
104MP0005253_abnormal_eye_physiology0.76772491
105MP0002085_abnormal_embryonic_tissue0.74764730
106MP0009672_abnormal_birth_weight0.74220967
107MP0005187_abnormal_penis_morphology0.74007267
108MP0001984_abnormal_olfaction0.73372265
109MP0002080_prenatal_lethality0.72317288
110MP0003718_maternal_effect0.71718485
111MP0002084_abnormal_developmental_patter0.71667739
112MP0000343_altered_response_to0.71366118
113MP0002925_abnormal_cardiovascular_devel0.68392626
114MP0003195_calcinosis0.68170455
115MP0002638_abnormal_pupillary_reflex0.67243037
116MP0005075_abnormal_melanosome_morpholog0.66542745
117MP0002108_abnormal_muscle_morphology0.66530625
118MP0000313_abnormal_cell_death0.65087012
119MP0004147_increased_porphyrin_level0.64694323
120MP0008932_abnormal_embryonic_tissue0.62599328
121MP0002210_abnormal_sex_determination0.62059988
122MP0003566_abnormal_cell_adhesion0.61691323
123MP0001243_abnormal_dermal_layer0.61533799
124MP0009046_muscle_twitch0.60474201
125MP0010386_abnormal_urinary_bladder0.60199468
126MP0001119_abnormal_female_reproductive0.60056894
127MP0000358_abnormal_cell_content/0.59829580
128MP0002234_abnormal_pharynx_morphology0.59725707
129MP0002128_abnormal_blood_circulation0.58900143
130MP0006054_spinal_hemorrhage0.58697607
131MP0005395_other_phenotype0.57590868
132MP0001529_abnormal_vocalization0.56470837
133MP0002896_abnormal_bone_mineralization0.55938263
134MP0001879_abnormal_lymphatic_vessel0.55333117
135MP0003941_abnormal_skin_development0.55257009
136MP0004924_abnormal_behavior0.54792558
137MP0005386_behavior/neurological_phenoty0.54792558
138MP0002019_abnormal_tumor_incidence0.54543089
139MP0002398_abnormal_bone_marrow0.53296044
140MP0008961_abnormal_basal_metabolism0.53063484
141MP0005375_adipose_tissue_phenotype0.51320045
142MP0000569_abnormal_digit_pigmentation0.51068880
143MP0001835_abnormal_antigen_presentation0.49967388
144MP0003935_abnormal_craniofacial_develop0.49230793
145MP0000703_abnormal_thymus_morphology0.47681665
146MP0001784_abnormal_fluid_regulation0.47343626
147MP0003705_abnormal_hypodermis_morpholog0.47270744
148MP0001800_abnormal_humoral_immune0.47110358
149MP0000689_abnormal_spleen_morphology0.47097039

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.98627693
2Exercise-induced muscle cramps (HP:0003710)6.79586178
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.76681811
4Exercise-induced myalgia (HP:0003738)6.50388283
5Nemaline bodies (HP:0003798)6.46775226
6Muscle hypertrophy of the lower extremities (HP:0008968)5.43544102
7Calf muscle hypertrophy (HP:0008981)5.32902021
8Type 1 muscle fiber predominance (HP:0003803)4.81533187
9Subaortic stenosis (HP:0001682)4.66392800
10Abnormality of the left ventricular outflow tract (HP:0011103)4.66392800
11Muscle fiber splitting (HP:0003555)4.65024440
12Sudden death (HP:0001699)4.52486339
13Abnormality of the calf musculature (HP:0001430)4.00962697
14Myoglobinuria (HP:0002913)3.89762850
15Ventricular tachycardia (HP:0004756)3.89265820
16EMG: myopathic abnormalities (HP:0003458)3.85439232
17Distal arthrogryposis (HP:0005684)3.78636632
18Rhabdomyolysis (HP:0003201)3.72586884
19Increased connective tissue (HP:0009025)3.65167343
20Ulnar deviation of the wrist (HP:0003049)3.60701038
21Difficulty running (HP:0009046)3.60355142
22Hyporeflexia of lower limbs (HP:0002600)3.41542205
23Hypoplastic ischia (HP:0003175)3.40849553
24Myopathic facies (HP:0002058)3.39301958
25Rimmed vacuoles (HP:0003805)3.36453373
26Atrial fibrillation (HP:0005110)3.30578673
27Areflexia of lower limbs (HP:0002522)3.08675557
28Lipoatrophy (HP:0100578)3.05270909
29Primary atrial arrhythmia (HP:0001692)3.04892613
30Supraventricular tachycardia (HP:0004755)2.97068339
31Muscle stiffness (HP:0003552)2.91499794
32Calcaneovalgus deformity (HP:0001848)2.90891677
33Supraventricular arrhythmia (HP:0005115)2.87638352
34Myotonia (HP:0002486)2.85800392
35Abnormality of the ischium (HP:0003174)2.85138111
36Neck muscle weakness (HP:0000467)2.83803453
37Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.82564931
38Pelvic girdle muscle weakness (HP:0003749)2.80127380
39Round ear (HP:0100830)2.77469095
40Shoulder girdle muscle weakness (HP:0003547)2.75469211
41Deformed tarsal bones (HP:0008119)2.64512832
42Asymmetric septal hypertrophy (HP:0001670)2.58767769
43Slender build (HP:0001533)2.57949712
44Abnormality of the musculature of the pelvis (HP:0001469)2.57262027
45Abnormality of the hip-girdle musculature (HP:0001445)2.57262027
46Hyperglycemia (HP:0003074)2.51353454
47Abnormality of skeletal muscle fiber size (HP:0012084)2.45334065
48Distal lower limb muscle weakness (HP:0009053)2.45020191
49Absent phalangeal crease (HP:0006109)2.43981118
50Dilated cardiomyopathy (HP:0001644)2.40658613
51Abnormality of alanine metabolism (HP:0010916)2.37126057
52Hyperalaninemia (HP:0003348)2.37126057
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37126057
54Pheochromocytoma (HP:0002666)2.35919934
55Difficulty climbing stairs (HP:0003551)2.29056210
56Chromsome breakage (HP:0040012)2.26856534
57Malignant hyperthermia (HP:0002047)2.26671752
58Hip contracture (HP:0003273)2.17311212
59Centrally nucleated skeletal muscle fibers (HP:0003687)2.15835661
60Delayed gross motor development (HP:0002194)2.14352449
61Bundle branch block (HP:0011710)2.13826919
62Abnormality of lateral ventricle (HP:0030047)2.13428946
63Neuroendocrine neoplasm (HP:0100634)2.11257615
64Papillary thyroid carcinoma (HP:0002895)2.10140491
65Facial diplegia (HP:0001349)2.08713161
66Abnormality of the calcaneus (HP:0008364)2.08435597
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03049723
68Proximal amyotrophy (HP:0007126)2.00816265
69Gowers sign (HP:0003391)2.00540113
70Fetal akinesia sequence (HP:0001989)1.99362044
71Frequent falls (HP:0002359)1.98986950
72Ketoacidosis (HP:0001993)1.98964183
73Hyperkalemia (HP:0002153)1.98082691
74Ventricular arrhythmia (HP:0004308)1.93707898
75Unilateral renal agenesis (HP:0000122)1.93132309
76EMG: neuropathic changes (HP:0003445)1.92394053
77Spinal rigidity (HP:0003306)1.92095369
78Abnormal finger flexion creases (HP:0006143)1.91757262
79Limb-girdle muscle weakness (HP:0003325)1.91536980
80Insulin-resistant diabetes mellitus (HP:0000831)1.89999384
81Biliary tract neoplasm (HP:0100574)1.86659120
82Right ventricular cardiomyopathy (HP:0011663)1.86591927
83Hyperinsulinemic hypoglycemia (HP:0000825)1.86561047
84Increased variability in muscle fiber diameter (HP:0003557)1.85326963
85Scapular winging (HP:0003691)1.83887860
86Left ventricular hypertrophy (HP:0001712)1.82415290
87Abnormality of the pubic bones (HP:0003172)1.82078407
88Irregular epiphyses (HP:0010582)1.81632093
89Muscular dystrophy (HP:0003560)1.81291336
90Weak cry (HP:0001612)1.79099752
91Generalized muscle weakness (HP:0003324)1.77607950
92Distal lower limb amyotrophy (HP:0008944)1.76799702
93Limb-girdle muscle atrophy (HP:0003797)1.76671706
94Wrist flexion contracture (HP:0001239)1.74781358
95Mildly elevated creatine phosphokinase (HP:0008180)1.73897907
96Syncope (HP:0001279)1.73556566
97Abnormality of the shoulder girdle musculature (HP:0001435)1.73244687
98Cutaneous melanoma (HP:0012056)1.72806586
99Aplasia/Hypoplasia of the fovea (HP:0008060)1.72670880
100Hypoplasia of the fovea (HP:0007750)1.72670880
101Thyroid carcinoma (HP:0002890)1.71966321
102Heart block (HP:0012722)1.70266906
103Palpitations (HP:0001962)1.69980940
104Abnormality of the fingertips (HP:0001211)1.69309043
105Small epiphyses (HP:0010585)1.69218719
106Limited hip movement (HP:0008800)1.68715892
107Hypoglycemic coma (HP:0001325)1.66096908
108Waddling gait (HP:0002515)1.65760404
109Fair hair (HP:0002286)1.65526140
110Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.63658732
111Intestinal atresia (HP:0011100)1.62507200
112Urethral obstruction (HP:0000796)1.61609657
113Type II lissencephaly (HP:0007260)1.60557806
114Progressive inability to walk (HP:0002505)1.60229693
115Metatarsus adductus (HP:0001840)1.59334404
116Birth length less than 3rd percentile (HP:0003561)1.58297817
117Atrioventricular block (HP:0001678)1.57326257
118Renal cortical cysts (HP:0000803)1.57059111
119Volvulus (HP:0002580)1.56496787
120Abnormal atrioventricular conduction (HP:0005150)1.55941028
121Preauricular pit (HP:0004467)1.55697034
122Periauricular skin pits (HP:0100277)1.55697034
123Congenital malformation of the right heart (HP:0011723)1.53218482
124Double outlet right ventricle (HP:0001719)1.53218482
125Hamartoma of the eye (HP:0010568)1.52777049
126Abnormality of the fovea (HP:0000493)1.51710019
127Fatigable weakness (HP:0003473)1.51658832
128Abnormality of the neuromuscular junction (HP:0003398)1.51658832
129Short palpebral fissure (HP:0012745)1.51396939
130Metaphyseal dysplasia (HP:0100255)1.51376354
131Tongue fasciculations (HP:0001308)1.51061876
132Aplasia/Hypoplasia of the uvula (HP:0010293)1.50931829
133Ependymoma (HP:0002888)1.50004239
134Long clavicles (HP:0000890)1.49364886
135Agnosia (HP:0010524)1.49237387
136Neoplasm of the peripheral nervous system (HP:0100007)1.49194154
137Albinism (HP:0001022)1.48305087
138Hypokinesia (HP:0002375)1.48083958
139Progressive muscle weakness (HP:0003323)1.45553969
140Hyperphosphatemia (HP:0002905)1.45091926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.72772046
2FRK4.23012147
3TTN4.18946574
4NEK13.31840328
5PHKG23.08995837
6PHKG13.08995837
7PDK22.72096776
8MST42.57949762
9STK242.57276408
10CDC72.46686539
11LATS12.37369577
12STK38L2.32129620
13EIF2AK32.31248528
14NEK92.27595582
15PDK42.13217146
16PDK32.13217146
17ZAK2.09439986
18ACVR1B1.85604577
19TRIM281.84911355
20PKN21.75202030
21CDK121.71289754
22MAP2K31.70952563
23LATS21.54140451
24PLK41.53783496
25DMPK1.47113598
26CDK81.41553692
27PNCK1.40558256
28MUSK1.38944317
29NME11.38169878
30MAP3K41.37820373
31STK31.34506432
32NEK21.32458725
33MAPK121.19772511
34TTK1.17702775
35MAP3K61.17387859
36RPS6KA41.14278801
37ERBB31.10497449
38TRIB31.09745356
39SRPK11.08990011
40PINK11.06401935
41CHEK21.06323592
42LIMK11.05027775
43MAP4K11.04325619
44MAP3K51.03736823
45PAK31.03264913
46TXK0.99439202
47DYRK30.98990086
48PIK3CA0.97350357
49MAP3K120.97255544
50BRSK20.95198925
51MELK0.95074265
52STK100.94790060
53EEF2K0.93206116
54MAP3K20.92778044
55BMPR1B0.92440377
56STK40.90793284
57MARK30.87760936
58CCNB10.87387334
59MAP3K70.86916654
60SGK20.85831361
61PRKAA10.84826072
62PLK10.84604756
63PLK20.84313754
64TGFBR10.84202841
65MAPK130.84155696
66CDK40.82968556
67CASK0.82763496
68MKNK10.81979170
69PRKAA20.81663640
70BMPR20.80531637
71FLT30.80119533
72TAOK20.79446913
73WEE10.79366689
74MAP3K30.78837092
75AURKB0.76985513
76PIK3CG0.76223138
77WNK30.75353084
78FER0.75331619
79FGFR20.74970126
80CSNK1G10.73155672
81TRPM70.73107803
82MKNK20.73026585
83EPHA30.70316054
84SGK30.68820161
85AKT30.68560791
86CAMKK20.67449751
87CHEK10.67272565
88SIK30.66515844
89PLK30.66220417
90ATR0.63356004
91EIF2AK10.62740431
92PTK2B0.59263272
93CAMK2D0.57932671
94BCR0.57694910
95ATM0.55325743
96LMTK20.54892982
97PRKCE0.53974563
98PIM10.53744513
99CDK90.53687746
100SCYL20.51720099
101ILK0.50868787
102MYLK0.50648007
103GRK10.50476167
104YES10.50139422
105TAOK10.49470735
106MAP3K80.47764807
107JAK10.46417239
108CSNK1G30.44377172
109BRD40.44165303
110EIF2AK20.43982412
111KIT0.43769493
112CAMK2G0.43756466
113MAP2K10.43630188
114STK380.43446171
115MAPKAPK30.42955230
116CAMK2A0.42694332
117MAPK70.41725028
118KSR10.41623994
119CSNK1G20.41465443
120CDK20.41154277
121MAP2K60.40475691
122CDK70.39765812
123BUB10.38804412
124TYK20.37218352
125PRKG10.35939437
126FGFR30.34857557
127PRKACB0.34777474
128MAPK110.34554335
129CSNK1D0.34272114
130CAMK40.33829383
131CSF1R0.33640945
132STK390.32110666
133ADRBK20.32100720
134ROCK10.31577387
135AKT20.31394280
136BRSK10.31058374
137MAP3K140.30921777
138CDK10.30165452
139RPS6KB20.28979986
140CHUK0.28755334
141MAP2K70.28446077
142NLK0.28071302
143JAK30.27524720
144MAP2K40.26822044
145MTOR0.26692761
146ERBB40.26492198
147BRAF0.26453357
148KSR20.24854819
149RPS6KB10.23653940
150MARK10.21689293

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.45874259
2Protein export_Homo sapiens_hsa030602.92621632
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.90708682
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.66009864
5Dilated cardiomyopathy_Homo sapiens_hsa054142.54372466
6Cell cycle_Homo sapiens_hsa041102.45308219
7Sulfur metabolism_Homo sapiens_hsa009202.37882470
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.37411051
9DNA replication_Homo sapiens_hsa030302.29993211
10Mismatch repair_Homo sapiens_hsa034302.24034122
11RNA transport_Homo sapiens_hsa030132.14662860
12Cardiac muscle contraction_Homo sapiens_hsa042602.08097528
13Fatty acid elongation_Homo sapiens_hsa000622.06924520
14RNA degradation_Homo sapiens_hsa030182.05373389
15Base excision repair_Homo sapiens_hsa034101.99311877
16Viral myocarditis_Homo sapiens_hsa054161.97562402
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.97131718
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94005041
19Regulation of autophagy_Homo sapiens_hsa041401.86329892
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.74116542
21Circadian rhythm_Homo sapiens_hsa047101.70300245
22Folate biosynthesis_Homo sapiens_hsa007901.67752024
23Non-homologous end-joining_Homo sapiens_hsa034501.66310092
24Dorso-ventral axis formation_Homo sapiens_hsa043201.64363479
25Fanconi anemia pathway_Homo sapiens_hsa034601.61776804
26Homologous recombination_Homo sapiens_hsa034401.59834534
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57995877
28RNA polymerase_Homo sapiens_hsa030201.57246647
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53109463
30Basal transcription factors_Homo sapiens_hsa030221.52438944
31Nucleotide excision repair_Homo sapiens_hsa034201.45195001
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44788288
33mRNA surveillance pathway_Homo sapiens_hsa030151.34855422
34p53 signaling pathway_Homo sapiens_hsa041151.33596237
35Butanoate metabolism_Homo sapiens_hsa006501.31204986
36Spliceosome_Homo sapiens_hsa030401.30295118
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25749895
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24370003
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20510147
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20072866
41Carbon metabolism_Homo sapiens_hsa012001.19064095
42Insulin secretion_Homo sapiens_hsa049111.17860392
43Inositol phosphate metabolism_Homo sapiens_hsa005621.13450583
44MicroRNAs in cancer_Homo sapiens_hsa052061.12443171
45Insulin signaling pathway_Homo sapiens_hsa049101.12031227
46HIF-1 signaling pathway_Homo sapiens_hsa040661.11935202
47Insulin resistance_Homo sapiens_hsa049311.11279917
48Selenocompound metabolism_Homo sapiens_hsa004501.10517501
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08785492
50Oocyte meiosis_Homo sapiens_hsa041141.06039368
51mTOR signaling pathway_Homo sapiens_hsa041501.05217686
52Herpes simplex infection_Homo sapiens_hsa051681.04890508
53FoxO signaling pathway_Homo sapiens_hsa040681.03720640
54Epstein-Barr virus infection_Homo sapiens_hsa051691.02540894
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00121127
56Glucagon signaling pathway_Homo sapiens_hsa049220.99895882
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98788952
58B cell receptor signaling pathway_Homo sapiens_hsa046620.95516265
59HTLV-I infection_Homo sapiens_hsa051660.92349463
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91827560
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91407454
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89598524
63Viral carcinogenesis_Homo sapiens_hsa052030.89405848
64Adherens junction_Homo sapiens_hsa045200.88730992
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86218125
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85585394
67Lysine degradation_Homo sapiens_hsa003100.83528440
68AMPK signaling pathway_Homo sapiens_hsa041520.83260559
69Colorectal cancer_Homo sapiens_hsa052100.81994883
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81957760
71Oxytocin signaling pathway_Homo sapiens_hsa049210.81931866
72Pancreatic cancer_Homo sapiens_hsa052120.81104170
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81081304
74Primary immunodeficiency_Homo sapiens_hsa053400.80540041
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80188802
76Long-term depression_Homo sapiens_hsa047300.79349739
77Sphingolipid metabolism_Homo sapiens_hsa006000.78076107
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76168160
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.76097760
80TGF-beta signaling pathway_Homo sapiens_hsa043500.75921923
81Small cell lung cancer_Homo sapiens_hsa052220.74772950
82Platelet activation_Homo sapiens_hsa046110.74464394
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74422094
84Pyrimidine metabolism_Homo sapiens_hsa002400.74170031
85Fatty acid metabolism_Homo sapiens_hsa012120.73078385
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71993083
87Propanoate metabolism_Homo sapiens_hsa006400.71977076
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71597534
89Purine metabolism_Homo sapiens_hsa002300.71228019
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70932437
91Focal adhesion_Homo sapiens_hsa045100.70823355
92Biosynthesis of amino acids_Homo sapiens_hsa012300.69391650
93Renal cell carcinoma_Homo sapiens_hsa052110.69043316
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.68351375
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.68235730
96T cell receptor signaling pathway_Homo sapiens_hsa046600.65856831
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.63587559
98Measles_Homo sapiens_hsa051620.62908214
99Proteasome_Homo sapiens_hsa030500.62687214
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62291728
101Renin secretion_Homo sapiens_hsa049240.62042082
102Toxoplasmosis_Homo sapiens_hsa051450.62025526
103Leishmaniasis_Homo sapiens_hsa051400.61524792
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.61318565
105One carbon pool by folate_Homo sapiens_hsa006700.61176946
106Collecting duct acid secretion_Homo sapiens_hsa049660.60088648
107Pentose phosphate pathway_Homo sapiens_hsa000300.59605955
108Influenza A_Homo sapiens_hsa051640.59445233
109Endometrial cancer_Homo sapiens_hsa052130.58803826
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58155866
111Chronic myeloid leukemia_Homo sapiens_hsa052200.58112362
112Phototransduction_Homo sapiens_hsa047440.57165292
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57095095
114Legionellosis_Homo sapiens_hsa051340.54861064
115Hematopoietic cell lineage_Homo sapiens_hsa046400.53684042
116Tight junction_Homo sapiens_hsa045300.53321564
117Hepatitis B_Homo sapiens_hsa051610.53165737
118Calcium signaling pathway_Homo sapiens_hsa040200.52445845
119MAPK signaling pathway_Homo sapiens_hsa040100.51762104
120Systemic lupus erythematosus_Homo sapiens_hsa053220.51640271
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51382607
122Peroxisome_Homo sapiens_hsa041460.51167724
123Apoptosis_Homo sapiens_hsa042100.50586299
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.50107267
125Acute myeloid leukemia_Homo sapiens_hsa052210.49964442
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49626239
127ABC transporters_Homo sapiens_hsa020100.49603803
128Non-small cell lung cancer_Homo sapiens_hsa052230.49573836
129Starch and sucrose metabolism_Homo sapiens_hsa005000.48224881
130Notch signaling pathway_Homo sapiens_hsa043300.48110265
131Prolactin signaling pathway_Homo sapiens_hsa049170.48006292
132Huntingtons disease_Homo sapiens_hsa050160.48005780
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47850130
134Melanoma_Homo sapiens_hsa052180.47111157
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.46929119
136Dopaminergic synapse_Homo sapiens_hsa047280.46719068
137Type II diabetes mellitus_Homo sapiens_hsa049300.45670592
138Thyroid cancer_Homo sapiens_hsa052160.45008029
139Parkinsons disease_Homo sapiens_hsa050120.44989647
140Osteoclast differentiation_Homo sapiens_hsa043800.44033041
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43767879
142Glioma_Homo sapiens_hsa052140.42710446
143Lysosome_Homo sapiens_hsa041420.33979327
144Amphetamine addiction_Homo sapiens_hsa050310.33883204
145Vibrio cholerae infection_Homo sapiens_hsa051100.33729259
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.33432307
147Shigellosis_Homo sapiens_hsa051310.29817113
148Arginine and proline metabolism_Homo sapiens_hsa003300.29272198
149Proteoglycans in cancer_Homo sapiens_hsa052050.28043892
150Circadian entrainment_Homo sapiens_hsa047130.25805110
151Oxidative phosphorylation_Homo sapiens_hsa001900.25102926
152N-Glycan biosynthesis_Homo sapiens_hsa005100.23319882

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