PHYKPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This is a nuclear gene encoding a mitochondrial enzyme that catalyzes the conversion of 5-phosphonooxy-L-lysine to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. Mutations in this gene may cause phosphohydroxylysinuria. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.53372796
2negative regulation of cell killing (GO:0031342)5.44734173
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.44734173
4secondary heart field specification (GO:0003139)4.93783660
5heart field specification (GO:0003128)4.93783660
6regulation of gamma-delta T cell differentiation (GO:0045586)4.92661737
7regulation of gamma-delta T cell activation (GO:0046643)4.87760008
8replication fork processing (GO:0031297)4.86478660
9maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.77752366
10antigen processing and presentation of endogenous antigen (GO:0019883)4.74638729
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.71373997
12DNA double-strand break processing (GO:0000729)4.68988633
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.65765560
14DNA deamination (GO:0045006)4.64151302
15meiotic chromosome segregation (GO:0045132)4.54020563
16kinetochore assembly (GO:0051382)4.52265802
17regulation of B cell receptor signaling pathway (GO:0050855)4.35888600
18kinetochore organization (GO:0051383)4.30610909
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.23646568
20DNA strand renaturation (GO:0000733)4.17519699
21positive thymic T cell selection (GO:0045059)4.11482666
22negative thymic T cell selection (GO:0045060)4.06270280
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.03727643
24negative T cell selection (GO:0043383)4.02600001
25regulation of nuclear cell cycle DNA replication (GO:0033262)3.96932658
26specification of organ identity (GO:0010092)3.91652648
27DNA ligation (GO:0006266)3.89363439
28positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.85035354
29telomere maintenance via semi-conservative replication (GO:0032201)3.82033550
30negative regulation of DNA-dependent DNA replication (GO:2000104)3.73814531
31positive T cell selection (GO:0043368)3.68560268
32detection of bacterium (GO:0016045)3.64003857
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.62526437
34DNA integration (GO:0015074)3.61012444
35B cell receptor signaling pathway (GO:0050853)3.59506322
36proline biosynthetic process (GO:0006561)3.56397195
37detection of other organism (GO:0098543)3.56196615
38T cell selection (GO:0045058)3.52786087
39viral mRNA export from host cell nucleus (GO:0046784)3.51905909
40cellular response to exogenous dsRNA (GO:0071360)3.50710500
41thymic T cell selection (GO:0045061)3.50433088
42regulation of dendritic cell antigen processing and presentation (GO:0002604)3.50313490
43immunoglobulin mediated immune response (GO:0016064)3.45331436
44cellular response to interleukin-15 (GO:0071350)3.43905440
45poly(A)+ mRNA export from nucleus (GO:0016973)3.43838483
46maturation of 5.8S rRNA (GO:0000460)3.42729598
47negative regulation of T cell mediated immunity (GO:0002710)3.41077490
48response to interleukin-15 (GO:0070672)3.39127009
49telomere maintenance via recombination (GO:0000722)3.37624276
50positive regulation of granulocyte differentiation (GO:0030854)3.34374449
51proline metabolic process (GO:0006560)3.30924237
52regulation of double-strand break repair via homologous recombination (GO:0010569)3.29512615
53protein K6-linked ubiquitination (GO:0085020)3.27279137
54positive regulation of B cell differentiation (GO:0045579)3.25875934
55somatic hypermutation of immunoglobulin genes (GO:0016446)3.24678326
56somatic diversification of immune receptors via somatic mutation (GO:0002566)3.24678326
57positive regulation of DNA repair (GO:0045739)3.23993422
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.21499873
59oxidative demethylation (GO:0070989)3.21036107
60leukocyte aggregation (GO:0070486)3.20423469
61cardiac ventricle formation (GO:0003211)3.19354603
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.19007599
63regulation of B cell differentiation (GO:0045577)3.17031772
64positive regulation of antigen processing and presentation (GO:0002579)3.16674988
65response to muramyl dipeptide (GO:0032495)3.16417984
66ribosomal large subunit biogenesis (GO:0042273)3.14421664
67regulation of development, heterochronic (GO:0040034)3.13663819
68DNA dealkylation (GO:0035510)3.13232978
69regulation of alpha-beta T cell proliferation (GO:0046640)3.11710884
70negative regulation of leukocyte mediated immunity (GO:0002704)3.11487103
71telomere maintenance via telomere lengthening (GO:0010833)3.09799071
72mitotic recombination (GO:0006312)3.08601712
73response to type I interferon (GO:0034340)3.08597550
74modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.07605572
75positive regulation by organism of defense response of other organism involved in symbiotic interact3.07605572
76modulation by symbiont of host immune response (GO:0052553)3.07605572
77positive regulation by symbiont of host defense response (GO:0052509)3.07605572
78modulation by symbiont of host defense response (GO:0052031)3.07605572
79modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.07605572
80cardiac chamber formation (GO:0003207)3.06611202
81regulation of antigen processing and presentation (GO:0002577)3.06464082
82regulation of timing of cell differentiation (GO:0048505)3.05407375
83tolerance induction (GO:0002507)3.05322024
84regulation of regulatory T cell differentiation (GO:0045589)3.05265829
85defense response to protozoan (GO:0042832)3.04958736
86transcription from mitochondrial promoter (GO:0006390)3.03254232
87germinal center formation (GO:0002467)3.01839224
88DNA strand elongation involved in DNA replication (GO:0006271)3.00516382
89DNA catabolic process, exonucleolytic (GO:0000738)3.00237778
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.99672721
91response to folic acid (GO:0051593)2.99605578
92Peyers patch development (GO:0048541)2.99324382
93mucosal-associated lymphoid tissue development (GO:0048537)2.99324382
94proteasome assembly (GO:0043248)2.98434160
95CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.98227620
96regulation of interleukin-12 biosynthetic process (GO:0045075)2.98099362
97negative regulation of innate immune response (GO:0045824)2.97622684
98cellular response to type I interferon (GO:0071357)2.97594549
99type I interferon signaling pathway (GO:0060337)2.97594549
100lymph node development (GO:0048535)2.95409936
101regulation of T cell mediated cytotoxicity (GO:0001914)2.95014153
102DNA strand elongation (GO:0022616)2.93116801
103negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92648767
104negative regulation of T-helper cell differentiation (GO:0045623)2.92648767
105antigen processing and presentation via MHC class Ib (GO:0002475)2.91983873
106detection of external biotic stimulus (GO:0098581)2.90986261
107base-excision repair, AP site formation (GO:0006285)2.90799663
108face development (GO:0060324)2.89974333
109regulation of granulocyte differentiation (GO:0030852)2.89497303
110regulation of interferon-beta biosynthetic process (GO:0045357)2.88680218
111activated T cell proliferation (GO:0050798)2.88462723
112negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.88044153
113response to peptidoglycan (GO:0032494)2.87640835
114T cell migration (GO:0072678)2.86060896
115interferon-gamma-mediated signaling pathway (GO:0060333)2.85504685
116macrophage activation involved in immune response (GO:0002281)2.84182535
117regulation of T cell tolerance induction (GO:0002664)2.84177254
118mannose metabolic process (GO:0006013)2.83775339
119regulation of tolerance induction (GO:0002643)2.82457438
120cellular response to ATP (GO:0071318)2.81202275
121termination of RNA polymerase II transcription (GO:0006369)2.79077257
122negative regulation of cell cycle arrest (GO:0071157)2.77932345
123regulation of double-strand break repair (GO:2000779)2.76965533
124CENP-A containing nucleosome assembly (GO:0034080)2.76175789
125chromatin remodeling at centromere (GO:0031055)2.76034480
126negative regulation of alpha-beta T cell activation (GO:0046636)2.75766039
127interferon-gamma production (GO:0032609)2.75659391
128lateral sprouting from an epithelium (GO:0060601)2.75503917
129negative regulation of interleukin-12 production (GO:0032695)2.75076321
130nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75004234
131response to protozoan (GO:0001562)2.74948904
132negative regulation of erythrocyte differentiation (GO:0045647)2.73892904
133B cell homeostasis (GO:0001782)2.73278354
134antigen receptor-mediated signaling pathway (GO:0050851)2.72790572
135regulation of mast cell degranulation (GO:0043304)2.72195388
136histone mRNA metabolic process (GO:0008334)2.71503648
137DNA topological change (GO:0006265)2.71243089
138regulation of natural killer cell mediated immunity (GO:0002715)2.69877867
139regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.69877867
140positive regulation of T cell mediated cytotoxicity (GO:0001916)2.69871656
141positive regulation of tolerance induction (GO:0002645)2.69334159
142dendritic cell chemotaxis (GO:0002407)2.69107910
143exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68235752
144DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.67773994
145neutrophil activation (GO:0042119)2.67452549
146regulation of DNA repair (GO:0006282)2.66897133
147mast cell activation (GO:0045576)2.66360604
148DNA demethylation (GO:0080111)2.65494035
149embryonic process involved in female pregnancy (GO:0060136)2.65171528
150regulation of germinal center formation (GO:0002634)2.64906025
151negative regulation of adaptive immune response (GO:0002820)2.64626480
152positive regulation of isotype switching (GO:0045830)2.64562653
153neutrophil activation involved in immune response (GO:0002283)2.64413676
154mismatch repair (GO:0006298)2.63886719
155positive regulation of developmental pigmentation (GO:0048087)2.63767061
156pseudouridine synthesis (GO:0001522)2.63427428
157DNA replication checkpoint (GO:0000076)2.63255960
158centriole assembly (GO:0098534)2.62904612
159positive regulation of protein homooligomerization (GO:0032464)2.62439048
160regulation of necroptotic process (GO:0060544)2.62228763
161ribosomal small subunit biogenesis (GO:0042274)2.61328682
162B cell mediated immunity (GO:0019724)2.60059277
163pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.59084199
164regulation of mast cell activation involved in immune response (GO:0033006)2.58992887
165negative regulation of interleukin-6 production (GO:0032715)2.56392345
166positive regulation of interferon-alpha production (GO:0032727)2.56276518
167T-helper cell differentiation (GO:0042093)2.56176615
168base-excision repair (GO:0006284)2.54378571
169rRNA modification (GO:0000154)2.54111745
170negative regulation of androgen receptor signaling pathway (GO:0060766)2.53507964
171microtubule depolymerization (GO:0007019)2.52885725
172mitochondrial DNA replication (GO:0006264)2.52197531
173mitochondrial DNA metabolic process (GO:0032042)2.51460769
174pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.51150743
175mitotic metaphase plate congression (GO:0007080)2.50973318
176telomere maintenance via telomerase (GO:0007004)2.50866739
177female gonad development (GO:0008585)2.50863757
178rRNA processing (GO:0006364)2.50540258
179regulation of gene expression by genetic imprinting (GO:0006349)2.49656078
180DNA-templated transcription, termination (GO:0006353)2.48108007
181telomere maintenance (GO:0000723)2.47966298
182negative regulation of mRNA processing (GO:0050686)2.47801803
183recombinational repair (GO:0000725)2.46480435
184DNA damage response, signal transduction resulting in transcription (GO:0042772)2.45699700
185maturation of SSU-rRNA (GO:0030490)2.45562346
186telomere organization (GO:0032200)2.43556980
187rRNA metabolic process (GO:0016072)2.43065503
188spliceosomal snRNP assembly (GO:0000387)2.42838598
189regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.42050449
190double-strand break repair via homologous recombination (GO:0000724)2.39775369
191DNA replication (GO:0006260)2.35290504
192DNA recombination (GO:0006310)2.35228497
193resolution of meiotic recombination intermediates (GO:0000712)2.34920047
194regulation of helicase activity (GO:0051095)2.34816123
195metaphase plate congression (GO:0051310)2.33913755
196regulation of integrin activation (GO:0033623)2.33685305
197tRNA modification (GO:0006400)2.32013412
198single strand break repair (GO:0000012)2.31836137
199positive regulation of neuroblast proliferation (GO:0002052)2.31111181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.91824246
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.32500526
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.91781217
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.90013758
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.76210142
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.33321904
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.33321904
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.33321904
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.18923605
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.13226989
11VDR_21846776_ChIP-Seq_THP-1_Human3.06236957
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.04447931
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89545890
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.82529107
15SCL_19346495_ChIP-Seq_HPC-7_Human2.81682560
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.77893348
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.72530364
18RUNX_20019798_ChIP-Seq_JUKART_Human2.72308291
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.70143312
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.70088784
21MYC_22102868_ChIP-Seq_BL_Human2.64500531
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.59979614
23VDR_24763502_ChIP-Seq_THP-1_Human2.56418721
24MAF_26560356_Chip-Seq_TH1_Human2.51253358
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49872629
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49355477
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.48409160
28MYB_26560356_Chip-Seq_TH2_Human2.38295361
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34271497
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32424865
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.32150359
32MAF_26560356_Chip-Seq_TH2_Human2.28026222
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27249588
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25989969
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25614006
36UTX_26944678_Chip-Seq_JUKART_Human2.22045118
37MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21457235
38POU5F1_16153702_ChIP-ChIP_HESCs_Human2.19631257
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17143356
40IRF8_27001747_Chip-Seq_BMDM_Mouse2.16126341
41MYB_26560356_Chip-Seq_TH1_Human2.15490157
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.13940284
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12870540
44MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08036549
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.07475739
46NOTCH1_21737748_ChIP-Seq_TLL_Human2.06471727
47PCGF2_27294783_Chip-Seq_NPCs_Mouse2.02583234
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.94833635
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.94737823
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91358212
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90610766
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.88429682
53TCF7_22412390_ChIP-Seq_EML_Mouse1.88197677
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.87463729
55SPI1_23547873_ChIP-Seq_NB4_Human1.86765006
56SPI1_23127762_ChIP-Seq_K562_Human1.83520742
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.83509143
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82854890
59ELK1_19687146_ChIP-ChIP_HELA_Human1.82310062
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81408327
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.79357091
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79320908
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77947656
64TCF3_18692474_ChIP-Seq_MESCs_Mouse1.77899861
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76904616
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.76528602
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.74589188
68KDM2B_26808549_Chip-Seq_DND41_Human1.72961340
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.72945405
70GATA3_27048872_Chip-Seq_THYMUS_Human1.70566793
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66272732
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.65745698
73TTF2_22483619_ChIP-Seq_HELA_Human1.63079864
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61261865
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58420390
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58395363
77VDR_23849224_ChIP-Seq_CD4+_Human1.58007991
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57803748
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56865499
80IRF1_19129219_ChIP-ChIP_H3396_Human1.56129792
81BCL6_27268052_Chip-Seq_Bcells_Human1.56044303
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55709006
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53641897
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51532710
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45700954
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45575095
87CIITA_25753668_ChIP-Seq_RAJI_Human1.45357252
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.44097057
89GATA3_26560356_Chip-Seq_TH2_Human1.43502420
90KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43306534
91EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42513007
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.42116249
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.41512911
94GATA1_22025678_ChIP-Seq_K562_Human1.41245268
95P300_18555785_Chip-Seq_ESCs_Mouse1.40918261
96LXR_22292898_ChIP-Seq_THP-1_Human1.39611278
97NMYC_18555785_Chip-Seq_ESCs_Mouse1.38262859
98IGF1R_20145208_ChIP-Seq_DFB_Human1.38217140
99MYC_18940864_ChIP-ChIP_HL60_Human1.37061277
100ETS1_20019798_ChIP-Seq_JURKAT_Human1.36943440
101PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36408646
102STAT3_18555785_Chip-Seq_ESCs_Mouse1.36373845
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36053859
104BCOR_27268052_Chip-Seq_Bcells_Human1.36012140
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35764319
106BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35116467
107OCT4_18555785_Chip-Seq_ESCs_Mouse1.34770143
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31964647
109ZFX_18555785_Chip-Seq_ESCs_Mouse1.31825734
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31691145
111HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31466369
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.31079987
113E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30973640
114NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30749227
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30225553
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29534556
117STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29298007
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28560249
119YY1_21170310_ChIP-Seq_MESCs_Mouse1.28457700
120GABP_17652178_ChIP-ChIP_JURKAT_Human1.27931495
121GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27842266
122DCP1A_22483619_ChIP-Seq_HELA_Human1.27734625
123KLF4_18555785_Chip-Seq_ESCs_Mouse1.27276030
124EWS_26573619_Chip-Seq_HEK293_Human1.27177467
125GATA1_19941826_ChIP-Seq_K562_Human1.26604845
126EZH2_27294783_Chip-Seq_NPCs_Mouse1.26387809
127ESRRB_18555785_Chip-Seq_ESCs_Mouse1.25407019
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25162476
129NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.23427125
130IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23126788
131RUNX1_27457419_Chip-Seq_LIVER_Mouse1.22384608
132VDR_24787735_ChIP-Seq_THP-1_Human1.22346789
133MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18277810
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18213498
135SMAD1_18555785_Chip-Seq_ESCs_Mouse1.16561932
136EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15975902
137HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15422971
138CTCF_18555785_Chip-Seq_ESCs_Mouse1.15232188
139STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15134083
140SOX2_16153702_ChIP-ChIP_HESCs_Human1.15066681
141TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15060041
142SRF_21415370_ChIP-Seq_HL-1_Mouse1.14787824
143ELK3_25401928_ChIP-Seq_HUVEC_Human1.14741421
144P68_20966046_ChIP-Seq_HELA_Human1.14730621
145CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14637104
146FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14319876
147ELF1_20517297_ChIP-Seq_JURKAT_Human1.12997705
148FOXP3_21729870_ChIP-Seq_TREG_Human1.12953765
149FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12847129
150ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12569319
151SOX2_18555785_Chip-Seq_ESCs_Mouse1.12266757
152P53_22387025_ChIP-Seq_ESCs_Mouse1.12099019
153P300_27268052_Chip-Seq_Bcells_Human1.11905265
154CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11627602
155CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10802915
156RNF2_27304074_Chip-Seq_NSC_Mouse1.10661445
157PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09729816
158GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09416504
159MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09177853
160RXR_22158963_ChIP-Seq_LIVER_Mouse1.09164887
161PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08814629
162GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08032095
163VDR_22108803_ChIP-Seq_LS180_Human1.07621251
164SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06553919
165TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06523840
166CMYC_18555785_Chip-Seq_ESCs_Mouse1.06523398
167CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06077181
168CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06015128
169KDM2B_26808549_Chip-Seq_JURKAT_Human1.05866554
170PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05853513
171ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05450569
172NANOG_18555785_Chip-Seq_ESCs_Mouse1.04807563
173SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04705743
174PU1_27457419_Chip-Seq_LIVER_Mouse1.04129532
175PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03186353
176CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03148833
177FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02241568
178SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01587517
179E2F1_20622854_ChIP-Seq_HELA_Human1.00680631
180SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00035813
181FUS_26573619_Chip-Seq_HEK293_Human0.99759885
182CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99472188
183CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99442104
184THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98632836
185CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98136600
186SA1_27219007_Chip-Seq_ERYTHROID_Human0.98088963
187PHF8_20622854_ChIP-Seq_HELA_Human0.95166907
188EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94616260
189CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94093869
190GATA2_21666600_ChIP-Seq_HMVEC_Human0.92932882
191PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92498472
192NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92405802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.29600634
2MP0001835_abnormal_antigen_presentation3.61937193
3MP0005171_absent_coat_pigmentation3.45857013
4MP0003436_decreased_susceptibility_to3.34317323
5MP0005671_abnormal_response_to3.25192760
6MP0001800_abnormal_humoral_immune3.17919740
7MP0000685_abnormal_immune_system3.09925881
8MP0006292_abnormal_olfactory_placode3.06307559
9MP0000566_synostosis3.05238457
10MP0008058_abnormal_DNA_repair2.88828588
11MP0010094_abnormal_chromosome_stability2.84326934
12MP0001790_abnormal_immune_system2.77496749
13MP0005387_immune_system_phenotype2.77496749
14MP0002009_preneoplasia2.74116081
15MP0005000_abnormal_immune_tolerance2.64736614
16MP0003136_yellow_coat_color2.62233425
17MP0003941_abnormal_skin_development2.61302221
18MP0002723_abnormal_immune_serum2.58318066
19MP0003303_peritoneal_inflammation2.50336051
20MP0005025_abnormal_response_to2.48083863
21MP0002452_abnormal_antigen_presenting2.42114265
22MP0002420_abnormal_adaptive_immunity2.39926716
23MP0002419_abnormal_innate_immunity2.37635865
24MP0001819_abnormal_immune_cell2.37457215
25MP0001873_stomach_inflammation2.30810413
26MP0005174_abnormal_tail_pigmentation2.29808987
27MP0009785_altered_susceptibility_to2.28542678
28MP0003111_abnormal_nucleus_morphology2.25154272
29MP0003693_abnormal_embryo_hatching2.21740697
30MP0002138_abnormal_hepatobiliary_system2.20804778
31MP0010155_abnormal_intestine_physiology2.19574257
32MP0004381_abnormal_hair_follicle2.14452389
33MP0002277_abnormal_respiratory_mucosa2.14143093
34MP0008932_abnormal_embryonic_tissue2.10724775
35MP0009379_abnormal_foot_pigmentation2.06964299
36MP0010030_abnormal_orbit_morphology2.05348128
37MP0003890_abnormal_embryonic-extraembry2.05139881
38MP0002398_abnormal_bone_marrow2.05002222
39MP0000716_abnormal_immune_system1.97695500
40MP0005360_urolithiasis1.94814838
41MP0001188_hyperpigmentation1.84852783
42MP0003866_abnormal_defecation1.83294519
43MP0000015_abnormal_ear_pigmentation1.81126833
44MP0005075_abnormal_melanosome_morpholog1.77071588
45MP0009333_abnormal_splenocyte_physiolog1.71470827
46MP0008995_early_reproductive_senescence1.63773958
47MP0008877_abnormal_DNA_methylation1.62703521
48MP0002722_abnormal_immune_system1.62416340
49MP0001845_abnormal_inflammatory_respons1.62174534
50MP0001293_anophthalmia1.62137411
51MP0003786_premature_aging1.61710316
52MP0003077_abnormal_cell_cycle1.58738333
53MP0002429_abnormal_blood_cell1.57082617
54MP0001533_abnormal_skeleton_physiology1.56953078
55MP0004133_heterotaxia1.56639703
56MP0002396_abnormal_hematopoietic_system1.56362412
57MP0006082_CNS_inflammation1.53234894
58MP0004947_skin_inflammation1.53196027
59MP0005409_darkened_coat_color1.49746502
60MP0000465_gastrointestinal_hemorrhage1.49218484
61MP0002102_abnormal_ear_morphology1.47569624
62MP0002132_abnormal_respiratory_system1.46863527
63MP0004957_abnormal_blastocyst_morpholog1.46457534
64MP0008469_abnormal_protein_level1.43594541
65MP0002249_abnormal_larynx_morphology1.41449193
66MP0003172_abnormal_lysosome_physiology1.41345392
67MP0005464_abnormal_platelet_physiology1.39351810
68MP0003718_maternal_effect1.38566725
69MP0008007_abnormal_cellular_replicative1.38464739
70MP0003938_abnormal_ear_development1.38388307
71MP0003724_increased_susceptibility_to1.36948035
72MP0005310_abnormal_salivary_gland1.36417364
73MP0000470_abnormal_stomach_morphology1.33877750
74MP0009764_decreased_sensitivity_to1.33687614
75MP0003183_abnormal_peptide_metabolism1.32116722
76MP0002095_abnormal_skin_pigmentation1.29286364
77MP0000490_abnormal_crypts_of1.28835696
78MP0005085_abnormal_gallbladder_physiolo1.26775512
79MP0002166_altered_tumor_susceptibility1.25622574
80MP0003252_abnormal_bile_duct1.25044975
81MP0002938_white_spotting1.24793484
82MP0002139_abnormal_hepatobiliary_system1.23244511
83MP0005397_hematopoietic_system_phenotyp1.23197434
84MP0001545_abnormal_hematopoietic_system1.23197434
85MP0005503_abnormal_tendon_morphology1.22976348
86MP0003300_gastrointestinal_ulcer1.22548290
87MP0001286_abnormal_eye_development1.21264479
88MP0005451_abnormal_body_composition1.19496955
89MP0001663_abnormal_digestive_system1.16739145
90MP0002163_abnormal_gland_morphology1.16293410
91MP0000613_abnormal_salivary_gland1.15831805
92MP0001186_pigmentation_phenotype1.15735938
93MP0004130_abnormal_muscle_cell1.15242168
94MP0000049_abnormal_middle_ear1.14415113
95MP0000371_diluted_coat_color1.13122744
96MP0003828_pulmonary_edema1.11609199
97MP0003195_calcinosis1.11326381
98MP0003755_abnormal_palate_morphology1.10467775
99MP0006072_abnormal_retinal_apoptosis1.10395088
100MP0003385_abnormal_body_wall1.10134712
101MP0005365_abnormal_bile_salt1.08865370
102MP0005058_abnormal_lysosome_morphology1.08051934
103MP0002098_abnormal_vibrissa_morphology1.07693319
104MP0002653_abnormal_ependyma_morphology1.07428481
105MP0001851_eye_inflammation1.06565322
106MP0002075_abnormal_coat/hair_pigmentati1.06227258
107MP0000462_abnormal_digestive_system1.03967873
108MP0003937_abnormal_limbs/digits/tail_de1.03535609
109MP0005379_endocrine/exocrine_gland_phen1.02861193
110MP0001764_abnormal_homeostasis1.02255054
111MP0002998_abnormal_bone_remodeling1.01196814
112MP0000579_abnormal_nail_morphology1.00700586
113MP0008961_abnormal_basal_metabolism0.99288307
114MP0000432_abnormal_head_morphology0.98206207
115MP0009115_abnormal_fat_cell0.98079130
116MP0000762_abnormal_tongue_morphology0.98072830
117MP0009278_abnormal_bone_marrow0.96662983
118MP0002210_abnormal_sex_determination0.94463099
119MP0005076_abnormal_cell_differentiation0.92654713
120MP0008789_abnormal_olfactory_epithelium0.92344203
121MP0001119_abnormal_female_reproductive0.92075338
122MP0002751_abnormal_autonomic_nervous0.91220226
123MP0003763_abnormal_thymus_physiology0.89699565
124MP0002933_joint_inflammation0.88360541
125MP0002111_abnormal_tail_morphology0.87606537
126MP0004808_abnormal_hematopoietic_stem0.87336058
127MP0001986_abnormal_taste_sensitivity0.87329486
128MP0004043_abnormal_pH_regulation0.87163735
129MP0003646_muscle_fatigue0.85912495
130MP0009763_increased_sensitivity_to0.85699458
131MP0009697_abnormal_copulation0.85259153
132MP0002136_abnormal_kidney_physiology0.84805430
133MP0000609_abnormal_liver_physiology0.83279418
134MP0003191_abnormal_cellular_cholesterol0.82590959
135MP0003656_abnormal_erythrocyte_physiolo0.81680808
136MP0000467_abnormal_esophagus_morphology0.81416562
137MP0000249_abnormal_blood_vessel0.80760036
138MP0002932_abnormal_joint_morphology0.80335673
139MP0002085_abnormal_embryonic_tissue0.80306987
140MP0009643_abnormal_urine_homeostasis0.79462015
141MP0008875_abnormal_xenobiotic_pharmacok0.79453946
142MP0001145_abnormal_male_reproductive0.78093788
143MP0010329_abnormal_lipoprotein_level0.76877416
144MP0002006_tumorigenesis0.76141803
145MP0002116_abnormal_craniofacial_bone0.76132994
146MP0002971_abnormal_brown_adipose0.76089658
147MP0000026_abnormal_inner_ear0.75977487
148MP0003935_abnormal_craniofacial_develop0.75511043
149MP0009765_abnormal_xenobiotic_induced0.74548694
150MP0005248_abnormal_Harderian_gland0.74426933
151MP0005391_vision/eye_phenotype0.73468369
152MP0002177_abnormal_outer_ear0.73149745
153MP0002060_abnormal_skin_morphology0.72922270
154MP0003045_fibrosis0.72682125
155MP0000350_abnormal_cell_proliferation0.71102537
156MP0005645_abnormal_hypothalamus_physiol0.70734059
157MP0000703_abnormal_thymus_morphology0.70175102
158MP0003119_abnormal_digestive_system0.70063215
159MP0005670_abnormal_white_adipose0.70026761
160MP0002148_abnormal_hypersensitivity_rea0.69486418
161MP0005083_abnormal_biliary_tract0.69465762
162MP0000313_abnormal_cell_death0.69195703
163MP0000653_abnormal_sex_gland0.68281203
164MP0001853_heart_inflammation0.68065440
165MP0004142_abnormal_muscle_tone0.68044826
166MP0009250_abnormal_appendicular_skeleto0.67488211
167MP0002118_abnormal_lipid_homeostasis0.67440693
168MP0005666_abnormal_adipose_tissue0.67389887
169MP0001346_abnormal_lacrimal_gland0.67353209
170MP0000372_irregular_coat_pigmentation0.67214660
171MP0005508_abnormal_skeleton_morphology0.66956223
172MP0005334_abnormal_fat_pad0.66887518
173MP0002405_respiratory_system_inflammati0.66600924
174MP0001340_abnormal_eyelid_morphology0.66396114
175MP0000689_abnormal_spleen_morphology0.66325648
176MP0008004_abnormal_stomach_pH0.66306547
177MP0001765_abnormal_ion_homeostasis0.66263977
178MP0002019_abnormal_tumor_incidence0.65796687
179MP0000383_abnormal_hair_follicle0.65571971
180MP0002114_abnormal_axial_skeleton0.65230064
181MP0003936_abnormal_reproductive_system0.65136213
182MP0003806_abnormal_nucleotide_metabolis0.64585961

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.92235712
2Chromsome breakage (HP:0040012)5.58724115
3Eczematoid dermatitis (HP:0000976)4.34803655
4Abnormal delayed hypersensitivity skin test (HP:0002963)4.12444409
5Recurrent fungal infections (HP:0002841)4.06999971
6Myositis (HP:0100614)3.97038659
7Duplicated collecting system (HP:0000081)3.89454707
8Recurrent bacterial skin infections (HP:0005406)3.83830835
9Recurrent abscess formation (HP:0002722)3.79791076
10Elevated erythrocyte sedimentation rate (HP:0003565)3.77692478
11Stomatitis (HP:0010280)3.68349340
12Recurrent cutaneous fungal infections (HP:0011370)3.63164964
13Chronic mucocutaneous candidiasis (HP:0002728)3.63164964
14Panhypogammaglobulinemia (HP:0003139)3.58088879
15T lymphocytopenia (HP:0005403)3.53423842
16Gastrointestinal infarctions (HP:0005244)3.48236714
17Abnormality of the preputium (HP:0100587)3.47797186
18Abnormality of the renal collecting system (HP:0004742)3.47639377
19Abnormality of the ileum (HP:0001549)3.46426003
20Agammaglobulinemia (HP:0004432)3.45931472
21Meningitis (HP:0001287)3.44975483
22Reticulocytopenia (HP:0001896)3.44560283
23Abnormality of T cell number (HP:0011839)3.44514654
24Mediastinal lymphadenopathy (HP:0100721)3.41795986
25Absent radius (HP:0003974)3.39792043
26Colitis (HP:0002583)3.34156594
27Optic neuritis (HP:0100653)3.33643372
28Retrobulbar optic neuritis (HP:0100654)3.33643372
29Orchitis (HP:0100796)3.33567675
30Recurrent gram-negative bacterial infections (HP:0005420)3.32957998
31Meckel diverticulum (HP:0002245)3.27167588
32Aplasia/Hypoplasia of the uvula (HP:0010293)3.26102513
33Encephalitis (HP:0002383)3.21658600
34Aplasia involving forearm bones (HP:0009822)3.16682055
35Absent forearm bone (HP:0003953)3.16682055
36Prolonged bleeding time (HP:0003010)3.12493753
37Abnormality of T cells (HP:0002843)3.11777196
38Abnormality of chromosome stability (HP:0003220)3.11010279
39Recurrent skin infections (HP:0001581)3.10186063
40Recurrent viral infections (HP:0004429)3.09625493
41Inflammation of the large intestine (HP:0002037)3.06113467
42Clubbing of toes (HP:0100760)3.03393540
43Rib fusion (HP:0000902)3.02374727
44Vasculitis (HP:0002633)3.01705254
45Abnormality of the fingertips (HP:0001211)2.98225009
46Abnormal number of incisors (HP:0011064)2.96741259
47Absent thumb (HP:0009777)2.96568206
48Capillary hemangiomas (HP:0005306)2.96538636
49Prostate neoplasm (HP:0100787)2.91662381
50Chronic obstructive pulmonary disease (HP:0006510)2.89836067
51Obstructive lung disease (HP:0006536)2.89836067
52Spontaneous hematomas (HP:0007420)2.87354286
53Gastrointestinal inflammation (HP:0004386)2.86199786
54Hemoptysis (HP:0002105)2.83550445
55IgG deficiency (HP:0004315)2.82801339
56Abnormality of macrophages (HP:0004311)2.79986708
57Patellar aplasia (HP:0006443)2.75793434
58Systemic lupus erythematosus (HP:0002725)2.75374700
59Pulmonary infiltrates (HP:0002113)2.74104967
60Epistaxis (HP:0000421)2.71202416
61Gingivitis (HP:0000230)2.70356239
62Abnormality of T cell physiology (HP:0011840)2.70350444
63Increased IgM level (HP:0003496)2.68173144
64Ectopic kidney (HP:0000086)2.63442079
65Recurrent bronchitis (HP:0002837)2.61695701
66Triphalangeal thumb (HP:0001199)2.61076453
67Severe combined immunodeficiency (HP:0004430)2.60659876
68Malnutrition (HP:0004395)2.60620567
69Intestinal atresia (HP:0011100)2.57341875
70Abnormality of male internal genitalia (HP:0000022)2.53136426
71Leukocytosis (HP:0001974)2.51054475
72Aplasia/Hypoplasia of the patella (HP:0006498)2.50627047
73Abnormality of the nasal septum (HP:0000419)2.50020655
74Abnormal hemoglobin (HP:0011902)2.49177692
75Chronic diarrhea (HP:0002028)2.46127619
76Abnormality of eosinophils (HP:0001879)2.44254957
77Autoimmune hemolytic anemia (HP:0001890)2.43925442
78Conical tooth (HP:0000698)2.43863251
79Short thumb (HP:0009778)2.43697675
80Increased IgE level (HP:0003212)2.42321665
81Concave nail (HP:0001598)2.38625208
82Nephroblastoma (Wilms tumor) (HP:0002667)2.37792970
83Autoimmune thrombocytopenia (HP:0001973)2.36775323
84Gingival bleeding (HP:0000225)2.34614061
85Duplication of thumb phalanx (HP:0009942)2.34371677
86Chest pain (HP:0100749)2.33580588
87Abnormality of the incisor (HP:0000676)2.32919173
88Rectovaginal fistula (HP:0000143)2.31774165
89Rectal fistula (HP:0100590)2.31774165
90Keratoconjunctivitis (HP:0001096)2.31522519
91Increased neuronal autofluorescent lipopigment (HP:0002074)2.30707638
92Intestinal fistula (HP:0100819)2.30697825
93Keratoconjunctivitis sicca (HP:0001097)2.30521522
94Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29758840
95Supernumerary spleens (HP:0009799)2.27881210
96Abnormality of the pleura (HP:0002103)2.25973455
97Anorexia (HP:0002039)2.25383459
98Premature graying of hair (HP:0002216)2.23947129
99Petechiae (HP:0000967)2.23286825
100Pulmonary embolism (HP:0002204)2.21066313
101Persistence of primary teeth (HP:0006335)2.20414936
102Alacrima (HP:0000522)2.19374298
103Hemorrhage of the eye (HP:0011885)2.19055667
104Embryonal renal neoplasm (HP:0011794)2.18829363
105Supernumerary bones of the axial skeleton (HP:0009144)2.16944548
106Cheilitis (HP:0100825)2.14617820
107Popliteal pterygium (HP:0009756)2.14523518
108Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14467080
109Lymphopenia (HP:0001888)2.14455668
110Gastrointestinal stroma tumor (HP:0100723)2.14274967
111Cellulitis (HP:0100658)2.14228964
112Complement deficiency (HP:0004431)2.14089754
113Abnormality of the carotid arteries (HP:0005344)2.12518362
114Hypoplasia of the radius (HP:0002984)2.12080047
115Congenital, generalized hypertrichosis (HP:0004540)2.11640585
116Pustule (HP:0200039)2.09952058
117Increased cerebral lipofuscin (HP:0011813)2.09298746
118Decreased lacrimation (HP:0000633)2.06827293
119Abnormality of pyrimidine metabolism (HP:0004353)2.05778711
120Septo-optic dysplasia (HP:0100842)2.05710758
121Breast hypoplasia (HP:0003187)2.05529850
122Abnormality of secondary sexual hair (HP:0009888)2.04948659
123Abnormality of the axillary hair (HP:0100134)2.04948659
124Aplastic anemia (HP:0001915)2.04212961
125Increased serum ferritin (HP:0003281)2.01922201
126Small intestinal stenosis (HP:0012848)2.01873259
127Duodenal stenosis (HP:0100867)2.01873259
128IgM deficiency (HP:0002850)1.99793357
129Clumsiness (HP:0002312)1.99560223
130Abnormality of incisor morphology (HP:0011063)1.97677852
131Myelodysplasia (HP:0002863)1.97603498
132Abnormality of DNA repair (HP:0003254)1.96491998
133Chronic otitis media (HP:0000389)1.96163659
134Abnormality of B cell number (HP:0010975)1.95820853
135Impulsivity (HP:0100710)1.95589312
136Abnormality of iron homeostasis (HP:0011031)1.95553592
137Supernumerary ribs (HP:0005815)1.95406226
138Median cleft lip (HP:0000161)1.94597767
139Abnormality of cells of the lymphoid lineage (HP:0012140)1.93444085
140Purpura (HP:0000979)1.93044736
141Joint swelling (HP:0001386)1.91354949
142Nasolacrimal duct obstruction (HP:0000579)1.91188332
143Verrucae (HP:0200043)1.90825876
144Papilloma (HP:0012740)1.90825876
145Thick nail (HP:0001805)1.89924820
146Hypochromic microcytic anemia (HP:0004840)1.87001248
147Abnormality of the septum pellucidum (HP:0007375)1.86952061
148Thyroiditis (HP:0100646)1.86796334
149Arterial thrombosis (HP:0004420)1.85543039
150Emphysema (HP:0002097)1.84951142
151Abnormality of transition element cation homeostasis (HP:0011030)1.84670616
152Restrictive lung disease (HP:0002091)1.84638890
153Alveolar cell carcinoma (HP:0006519)1.84552671
154Hematochezia (HP:0002573)1.84392807
155Acute lymphatic leukemia (HP:0006721)1.83927558
156Granulocytopenia (HP:0001913)1.83687201
157Seborrheic dermatitis (HP:0001051)1.82269725
158Aplasia cutis congenita (HP:0001057)1.82226713
159Abnormality of the labia minora (HP:0012880)1.81996454
160Vaginal fistula (HP:0004320)1.81503776
161Neoplasm of the tracheobronchial system (HP:0100552)1.81148519
162Microcytic anemia (HP:0001935)1.80728133
163Increased number of teeth (HP:0011069)1.80382472
164Facial hemangioma (HP:0000329)1.80162478
165Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80020023
166IgA deficiency (HP:0002720)1.79574672
167Sparse scalp hair (HP:0002209)1.78805765
168Bone marrow hypocellularity (HP:0005528)1.78659010
169Absent septum pellucidum (HP:0001331)1.77851143
170Congenital sensorineural hearing impairment (HP:0008527)1.77696313
171Hypochromic anemia (HP:0001931)1.76801792
172Eosinophilia (HP:0001880)1.76067917
173Microvesicular hepatic steatosis (HP:0001414)1.75291546
174Abnormality of the columella (HP:0009929)1.74343617
175Anal atresia (HP:0002023)1.73363181
176Horseshoe kidney (HP:0000085)1.73004612
177Pallor (HP:0000980)1.72915000
178Abnormality of the duodenum (HP:0002246)1.72726826
179Volvulus (HP:0002580)1.72393270
180Lip pit (HP:0100267)1.70055244
181Aplasia/hypoplasia of the humerus (HP:0006507)1.68554973
182White forelock (HP:0002211)1.67846112
183Stomach cancer (HP:0012126)1.66757378
184Optic nerve hypoplasia (HP:0000609)1.64085508
185Patchy hypopigmentation of hair (HP:0011365)1.63427308
186Abnormality of the prostate (HP:0008775)1.63083382
187Upper limb muscle weakness (HP:0003484)1.62355714
188Exertional dyspnea (HP:0002875)1.61835912
189Coronal craniosynostosis (HP:0004440)1.61254765
190Medulloblastoma (HP:0002885)1.60812169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.10386867
2TLK13.79678126
3IRAK33.11933531
4ZAK2.99993163
5GRK62.86562879
6RIPK42.83312991
7MKNK22.72023691
8BLK2.69165949
9MAPK152.65282440
10TAOK32.53946679
11PINK12.50271226
12STK162.49181448
13SRPK12.48273285
14INSRR2.26252222
15ERN12.22062194
16IRAK42.17786305
17PLK42.12885975
18TNK22.10601395
19FES2.10087166
20TYK22.09701908
21YES12.05665844
22IKBKE2.00961162
23MAP2K31.98878480
24BTK1.97164762
25MAP3K61.82507638
26SYK1.82173998
27MKNK11.79904280
28IRAK11.79286994
29TRIB31.77682570
30ZAP701.73171382
31VRK11.72117319
32BRD41.65535838
33KIT1.65376441
34IRAK21.63377855
35MAP3K131.63074077
36TBK11.61932581
37MAP3K71.56588102
38CASK1.52224473
39CDK71.48974502
40AKT31.47130181
41ITK1.43688348
42JAK31.42182607
43DYRK31.41110591
44TRPM71.37600932
45EIF2AK21.36425216
46JAK11.35820912
47CHEK21.32335842
48EPHA21.31975671
49DDR21.29815362
50LCK1.28969518
51FRK1.28798580
52MAP2K21.24811123
53CDC71.23305406
54CDK191.21769079
55PIM21.20710499
56ATR1.19161654
57HCK1.17627909
58CSK1.16248865
59TTK1.15607659
60PRKD21.15094151
61ACVR1B1.14125509
62ICK1.08721194
63MAPK111.08454828
64BMPR1B1.06769242
65STK41.05637233
66MARK21.05372700
67CSF1R1.04910977
68TNIK1.02611132
69STK38L1.01100689
70PLK10.98993132
71TXK0.98505985
72FGR0.97311423
73IKBKB0.94294398
74MAPK70.92771426
75PIM10.91714811
76MAPK120.89610692
77TAOK10.89230521
78MAP3K100.87936891
79PRPF4B0.86088729
80MARK30.83551719
81GRK70.82694589
82MAP2K60.81347383
83DYRK20.81093561
84MAP3K110.80300036
85MATK0.79023237
86PRKCQ0.78287772
87BUB10.77992885
88RPS6KA50.77706620
89FGFR40.77383875
90AURKB0.76865477
91ATM0.76125533
92NME10.74220160
93EIF2AK10.72473677
94PRKAA20.71045241
95CDC42BPA0.70537006
96JAK20.69277798
97NEK60.69273158
98CDK120.69047441
99MAP2K70.68615974
100CDK40.68601111
101TESK20.68375132
102PBK0.68181231
103LATS10.68003453
104CDK30.67732984
105PKN10.67056976
106TEC0.66772718
107ERBB30.65419964
108NLK0.65232191
109PDK10.64737963
110HIPK20.63947893
111NME20.63915592
112EPHB10.62935678
113ADRBK20.62187019
114SIK10.61699584
115CLK10.60403624
116UHMK10.60032094
117PNCK0.59116012
118LYN0.58797004
119MELK0.58364403
120MAP3K140.58109654
121BMPR20.57584615
122MAP3K10.56995757
123BRSK20.56262458
124KDR0.55914728
125CHUK0.54830169
126MAP3K30.54571754
127DYRK1B0.52903706
128PDPK10.52746280
129CHEK10.51655399
130CSNK2A10.51434503
131SIK20.51002353
132RPS6KC10.50798177
133RPS6KL10.50798177
134PIK3CA0.50737494
135CDK80.50366132
136GRK10.49877194
137PIK3CG0.49332520
138AURKA0.48733512
139CDK60.48600692
140PTK60.48257016
141MAPK130.47642433
142RPS6KA20.46149764
143MAPK30.45827589
144EPHA30.44375999
145CDK90.43873990
146FGFR30.43753003
147TGFBR20.43538752
148RPS6KA60.41178781
149CDK20.40938402
150WEE10.38812908
151PRKD10.38557708
152CDK10.38336321
153CAMKK10.37839707
154STK110.37747557
155NEK90.37341572
156NUAK10.36919282
157MST40.36119390
158MAPKAPK30.35876013
159CSNK2A20.35665322
160PLK30.35505787
161STK30.35317460
162GSK3A0.34992222
163FYN0.32956485
164MAPKAPK20.32593609
165MTOR0.32488798
166MUSK0.29811878

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.87277208
2Mismatch repair_Homo sapiens_hsa034303.74145895
3Homologous recombination_Homo sapiens_hsa034403.59448053
4DNA replication_Homo sapiens_hsa030303.44506501
5Base excision repair_Homo sapiens_hsa034102.98517692
6Ribosome_Homo sapiens_hsa030102.98306239
7Staphylococcus aureus infection_Homo sapiens_hsa051502.90263508
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.55757498
9Leishmaniasis_Homo sapiens_hsa051402.38403848
10Spliceosome_Homo sapiens_hsa030402.36458178
11Nucleotide excision repair_Homo sapiens_hsa034202.21902008
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.15480622
13RNA polymerase_Homo sapiens_hsa030202.13691358
14Osteoclast differentiation_Homo sapiens_hsa043802.10274931
15B cell receptor signaling pathway_Homo sapiens_hsa046622.06963711
16Non-homologous end-joining_Homo sapiens_hsa034502.04088798
17Type I diabetes mellitus_Homo sapiens_hsa049401.90566210
18Basal transcription factors_Homo sapiens_hsa030221.88533040
19One carbon pool by folate_Homo sapiens_hsa006701.78452459
20Systemic lupus erythematosus_Homo sapiens_hsa053221.77634279
21Cell cycle_Homo sapiens_hsa041101.62879718
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62868580
23T cell receptor signaling pathway_Homo sapiens_hsa046601.60984446
24Antigen processing and presentation_Homo sapiens_hsa046121.59458930
25RNA transport_Homo sapiens_hsa030131.57304402
26Pyrimidine metabolism_Homo sapiens_hsa002401.53952801
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.51185487
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50758069
29RNA degradation_Homo sapiens_hsa030181.48000584
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47021120
31p53 signaling pathway_Homo sapiens_hsa041151.42145195
32mRNA surveillance pathway_Homo sapiens_hsa030151.39422289
33Tuberculosis_Homo sapiens_hsa051521.37168280
34Acute myeloid leukemia_Homo sapiens_hsa052211.30882546
35Toxoplasmosis_Homo sapiens_hsa051451.30350180
36Primary immunodeficiency_Homo sapiens_hsa053401.29011151
37Protein export_Homo sapiens_hsa030601.27919636
38Arachidonic acid metabolism_Homo sapiens_hsa005901.26675481
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24595981
40TNF signaling pathway_Homo sapiens_hsa046681.22890138
41Herpes simplex infection_Homo sapiens_hsa051681.22427713
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21788916
43Graft-versus-host disease_Homo sapiens_hsa053321.14601326
44Caffeine metabolism_Homo sapiens_hsa002321.11689081
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.10465092
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09735637
47Sulfur relay system_Homo sapiens_hsa041221.07933905
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.07501233
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.03964771
50Basal cell carcinoma_Homo sapiens_hsa052171.02127395
51Chemokine signaling pathway_Homo sapiens_hsa040621.00887521
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99837791
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.99816970
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99716538
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98440983
56Complement and coagulation cascades_Homo sapiens_hsa046100.93723023
57Platelet activation_Homo sapiens_hsa046110.92880824
58Hepatitis C_Homo sapiens_hsa051600.91171218
59Fatty acid biosynthesis_Homo sapiens_hsa000610.90766701
60Pertussis_Homo sapiens_hsa051330.88998770
61Rheumatoid arthritis_Homo sapiens_hsa053230.88988834
62ABC transporters_Homo sapiens_hsa020100.88078046
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88063143
64TGF-beta signaling pathway_Homo sapiens_hsa043500.87872327
65Hematopoietic cell lineage_Homo sapiens_hsa046400.86277843
66Autoimmune thyroid disease_Homo sapiens_hsa053200.86086964
67Allograft rejection_Homo sapiens_hsa053300.84985743
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84510207
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84385511
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84263512
71Notch signaling pathway_Homo sapiens_hsa043300.82781852
72Measles_Homo sapiens_hsa051620.81990798
73Linoleic acid metabolism_Homo sapiens_hsa005910.81830192
74Insulin resistance_Homo sapiens_hsa049310.81438629
75Glycerolipid metabolism_Homo sapiens_hsa005610.81253856
76Chemical carcinogenesis_Homo sapiens_hsa052040.79917549
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79257021
78Purine metabolism_Homo sapiens_hsa002300.78180259
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.76722191
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.76271617
81MicroRNAs in cancer_Homo sapiens_hsa052060.76234243
82Hedgehog signaling pathway_Homo sapiens_hsa043400.76106487
83Proteasome_Homo sapiens_hsa030500.74716928
84Folate biosynthesis_Homo sapiens_hsa007900.72426650
85Epstein-Barr virus infection_Homo sapiens_hsa051690.70460635
86Wnt signaling pathway_Homo sapiens_hsa043100.70335370
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70244813
88Sphingolipid metabolism_Homo sapiens_hsa006000.69640419
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69288773
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68654616
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.67968175
92Ether lipid metabolism_Homo sapiens_hsa005650.67412027
93Asthma_Homo sapiens_hsa053100.65475774
94Histidine metabolism_Homo sapiens_hsa003400.65366876
95Phototransduction_Homo sapiens_hsa047440.64846059
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.64741170
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63462621
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61968581
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59881810
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59734208
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.58072422
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58043518
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.57693534
104Viral carcinogenesis_Homo sapiens_hsa052030.57290687
105Huntingtons disease_Homo sapiens_hsa050160.56812752
106Arginine and proline metabolism_Homo sapiens_hsa003300.56440737
107Apoptosis_Homo sapiens_hsa042100.56163780
108Other glycan degradation_Homo sapiens_hsa005110.56105369
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55932673
110Glutathione metabolism_Homo sapiens_hsa004800.54089083
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53841808
112Non-small cell lung cancer_Homo sapiens_hsa052230.53627209
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53219956
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53212195
115Alcoholism_Homo sapiens_hsa050340.52464464
116PPAR signaling pathway_Homo sapiens_hsa033200.51571442
117FoxO signaling pathway_Homo sapiens_hsa040680.51526232
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50782412
119Dorso-ventral axis formation_Homo sapiens_hsa043200.50450688
120Oxidative phosphorylation_Homo sapiens_hsa001900.50326090
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.47436383
122Legionellosis_Homo sapiens_hsa051340.47431572
123Fatty acid degradation_Homo sapiens_hsa000710.47270514
124* Lysine degradation_Homo sapiens_hsa003100.46208145
125Fat digestion and absorption_Homo sapiens_hsa049750.45940310
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45920347
127Hippo signaling pathway_Homo sapiens_hsa043900.45795432
128Prolactin signaling pathway_Homo sapiens_hsa049170.45543058
129HTLV-I infection_Homo sapiens_hsa051660.45246691
130Prostate cancer_Homo sapiens_hsa052150.44640806
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43807817
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43539468
133Pancreatic cancer_Homo sapiens_hsa052120.43183435
134Adherens junction_Homo sapiens_hsa045200.42068253
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41967404
136VEGF signaling pathway_Homo sapiens_hsa043700.41533883
137Choline metabolism in cancer_Homo sapiens_hsa052310.39890103
138Vitamin digestion and absorption_Homo sapiens_hsa049770.39817050
139Tryptophan metabolism_Homo sapiens_hsa003800.39793147
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38880459
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.38400219
142African trypanosomiasis_Homo sapiens_hsa051430.37655613
143Steroid biosynthesis_Homo sapiens_hsa001000.37165933
144Renin-angiotensin system_Homo sapiens_hsa046140.37149752
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.36448022
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36001063
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35908731
148Lysosome_Homo sapiens_hsa041420.35358929
149Parkinsons disease_Homo sapiens_hsa050120.33897612
150Malaria_Homo sapiens_hsa051440.32335609
151Viral myocarditis_Homo sapiens_hsa054160.30262154
152Hepatitis B_Homo sapiens_hsa051610.29955256
153Small cell lung cancer_Homo sapiens_hsa052220.29937734
154Pathways in cancer_Homo sapiens_hsa052000.29786647
155Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29133772
156Mineral absorption_Homo sapiens_hsa049780.28650366
157Circadian rhythm_Homo sapiens_hsa047100.28582818
158Retinol metabolism_Homo sapiens_hsa008300.28511100
159Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28164276
160Influenza A_Homo sapiens_hsa051640.26371281

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