PI15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of phosphoprotein phosphatase activity (GO:0032516)6.71684515
2negative regulation of protein localization to cell surface (GO:2000009)6.71024507
3retinal rod cell development (GO:0046548)5.99724996
4peripheral nervous system neuron development (GO:0048935)5.63157207
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.43066010
6negative regulation of neurotransmitter transport (GO:0051589)4.69268812
7presynaptic membrane organization (GO:0097090)4.52498128
8response to auditory stimulus (GO:0010996)4.51191061
9doxorubicin metabolic process (GO:0044598)4.41629643
10daunorubicin metabolic process (GO:0044597)4.41629643
11polyketide metabolic process (GO:0030638)4.41629643
12sequestering of extracellular ligand from receptor (GO:0035581)4.33591553
13detection of molecule of bacterial origin (GO:0032490)4.28655346
14cellular extravasation (GO:0045123)4.28242174
15negative regulation of axon extension involved in axon guidance (GO:0048843)4.27117828
16calcium-mediated signaling using intracellular calcium source (GO:0035584)4.19305109
17phasic smooth muscle contraction (GO:0014821)4.18423603
18collagen fibril organization (GO:0030199)4.01073937
19platelet dense granule organization (GO:0060155)3.97694434
20regulation of lipoprotein metabolic process (GO:0050746)3.96691121
21chondrocyte proliferation (GO:0035988)3.85966175
22positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.84837189
23mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.84837189
24mesenchymal cell differentiation involved in kidney development (GO:0072161)3.84425339
25mesenchymal cell differentiation involved in renal system development (GO:2001012)3.84425339
26cholesterol biosynthetic process (GO:0006695)3.79123756
27epithelial cilium movement (GO:0003351)3.74587413
28extracellular regulation of signal transduction (GO:1900115)3.70544141
29extracellular negative regulation of signal transduction (GO:1900116)3.70544141
30negative regulation of axon guidance (GO:1902668)3.60977903
31negative regulation of leukocyte chemotaxis (GO:0002689)3.60186413
32regulation of integrin-mediated signaling pathway (GO:2001044)3.56862366
33mesenchymal-epithelial cell signaling (GO:0060638)3.53578703
34negative regulation of protein activation cascade (GO:2000258)3.47429123
35presynaptic membrane assembly (GO:0097105)3.45228386
36superoxide anion generation (GO:0042554)3.43884217
37smooth muscle tissue development (GO:0048745)3.41080395
38regulation of Rac GTPase activity (GO:0032314)3.34477770
39sterol biosynthetic process (GO:0016126)3.34218440
40regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.30184754
41regulation of phospholipid biosynthetic process (GO:0071071)3.29998031
42bone trabecula formation (GO:0060346)3.29403558
43L-serine transport (GO:0015825)3.28782908
44metanephric mesenchyme development (GO:0072075)3.27764252
45negative regulation of osteoblast proliferation (GO:0033689)3.27223397
46cilium or flagellum-dependent cell motility (GO:0001539)3.26746644
47regulation of protein localization to cell surface (GO:2000008)3.26615660
48cysteine metabolic process (GO:0006534)3.25737731
49phospholipid homeostasis (GO:0055091)3.25692506
50regulation of penile erection (GO:0060405)3.25126380
51negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.24898461
52cGMP-mediated signaling (GO:0019934)3.24742749
53coronary vasculature morphogenesis (GO:0060977)3.24651436
54serine family amino acid catabolic process (GO:0009071)3.24617848
55keratan sulfate catabolic process (GO:0042340)3.22187661
56xenobiotic catabolic process (GO:0042178)3.21118962
57negative regulation of stem cell proliferation (GO:2000647)3.18380902
58neuron projection extension involved in neuron projection guidance (GO:1902284)3.18174326
59axon extension involved in axon guidance (GO:0048846)3.18174326
60oligodendrocyte differentiation (GO:0048709)3.14771940
61regulation of non-canonical Wnt signaling pathway (GO:2000050)3.14541670
62regulation of neurotransmitter uptake (GO:0051580)3.11438637
63mechanoreceptor differentiation (GO:0042490)3.11213838
64establishment of tissue polarity (GO:0007164)3.10394486
65establishment of planar polarity (GO:0001736)3.10394486
66negative regulation of keratinocyte proliferation (GO:0010839)3.10021181
67appendage development (GO:0048736)3.09538337
68limb development (GO:0060173)3.09538337
69response to lipoprotein particle (GO:0055094)3.09174702
70Notch signaling involved in heart development (GO:0061314)3.08546711
71fat-soluble vitamin catabolic process (GO:0042363)3.04526794
72vitamin catabolic process (GO:0009111)3.04526794
73cilium movement (GO:0003341)3.03781002
74L-glutamate transport (GO:0015813)3.00941883
75acidic amino acid transport (GO:0015800)2.99110527
76branched-chain amino acid catabolic process (GO:0009083)2.98838003
77positive regulation of vascular permeability (GO:0043117)2.97718974
78nephron tubule development (GO:0072080)2.97381298
79sulfur amino acid catabolic process (GO:0000098)2.95211662
80extracellular matrix assembly (GO:0085029)2.94432801
81positive regulation of heat generation (GO:0031652)2.93307358
82kidney mesenchyme development (GO:0072074)2.93299704
83detection of external biotic stimulus (GO:0098581)2.93186515
84regulation of fever generation (GO:0031620)2.92648064
85negative regulation of membrane potential (GO:0045837)2.91520044
86ganglion development (GO:0061548)2.90217022
87neural crest cell migration (GO:0001755)2.87862981
88calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.87268926
89fucose catabolic process (GO:0019317)2.86596304
90L-fucose metabolic process (GO:0042354)2.86596304
91L-fucose catabolic process (GO:0042355)2.86596304
92renal tubule development (GO:0061326)2.86576269
93negative regulation of humoral immune response (GO:0002921)2.85193862
94cilium morphogenesis (GO:0060271)2.85000020
95response to increased oxygen levels (GO:0036296)2.83711945
96response to hyperoxia (GO:0055093)2.83711945
97left/right axis specification (GO:0070986)2.83096351
98energy homeostasis (GO:0097009)2.82990925
99intraciliary transport (GO:0042073)2.77935639
100L-serine metabolic process (GO:0006563)2.77563280
101positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.77111944
102tongue development (GO:0043586)2.74616221
103positive regulation of mitochondrial fission (GO:0090141)2.74331394
104response to pheromone (GO:0019236)2.74271602
105cellular response to cholesterol (GO:0071397)2.73928794
106mesenchymal cell differentiation (GO:0048762)2.73705327
107coenzyme catabolic process (GO:0009109)2.72284023
108negative regulation of myoblast differentiation (GO:0045662)2.71368843
109neuronal stem cell maintenance (GO:0097150)2.70252558
110dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.69397964
111collagen catabolic process (GO:0030574)2.67485086
112negative regulation of neurological system process (GO:0031645)2.67198341
113radial glial cell differentiation (GO:0060019)2.67108378
114regulation of interleukin-8 secretion (GO:2000482)2.65788120
115cell differentiation involved in metanephros development (GO:0072202)2.65596623
116pyrimidine nucleobase catabolic process (GO:0006208)2.65410727
117cellular response to ATP (GO:0071318)2.63876999
118peroxisome organization (GO:0007031)2.63685670
119nucleotide transmembrane transport (GO:1901679)2.62390352
120detection of biotic stimulus (GO:0009595)2.60488175
121regulation of heat generation (GO:0031650)2.60049121
122collagen metabolic process (GO:0032963)2.59727746
123regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.59708881
124axonemal dynein complex assembly (GO:0070286)2.59689380
125serine transport (GO:0032329)2.58579919
126cilium assembly (GO:0042384)2.57727691
127cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.57018711
128positive regulation of cardiac muscle cell differentiation (GO:2000727)2.56533785
129G-protein coupled receptor internalization (GO:0002031)2.55319744
130regulation of chemokine-mediated signaling pathway (GO:0070099)2.54765921
131astrocyte development (GO:0014002)2.54321316
132vasodilation (GO:0042311)2.53887507
133positive regulation of respiratory burst (GO:0060267)2.53609507
134protein heterotrimerization (GO:0070208)2.49382426
135neural crest cell development (GO:0014032)2.49379223
136positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.49074881
137negative regulation of mast cell activation (GO:0033004)2.48420902
138female gonad development (GO:0008585)2.48062194
139aminoglycoside antibiotic metabolic process (GO:0030647)2.46894118
140cell proliferation involved in kidney development (GO:0072111)2.46736901
141dermatan sulfate metabolic process (GO:0030205)2.45122908
142dermatan sulfate biosynthetic process (GO:0030208)2.44811760
143embryonic cranial skeleton morphogenesis (GO:0048701)2.44619633
144regulation of cardiac muscle cell differentiation (GO:2000725)2.44395352
145retina vasculature morphogenesis in camera-type eye (GO:0061299)2.43855807
146multicellular organismal macromolecule metabolic process (GO:0044259)2.43752961
147negative chemotaxis (GO:0050919)2.42285836
148limb bud formation (GO:0060174)2.42269554
149multicellular organismal catabolic process (GO:0044243)2.39416461
150auditory receptor cell stereocilium organization (GO:0060088)2.34927397
151extracellular fibril organization (GO:0043206)2.34622542
152prostate gland growth (GO:0060736)2.33011846
153craniofacial suture morphogenesis (GO:0097094)2.32931273
154glomerular basement membrane development (GO:0032836)2.31338518
155mesonephros development (GO:0001823)2.31111974
156multicellular organismal metabolic process (GO:0044236)2.29858834
157inner ear receptor stereocilium organization (GO:0060122)2.29823692
158negative regulation of chondrocyte differentiation (GO:0032331)2.28241780
159superoxide metabolic process (GO:0006801)2.27356161
160negative regulation of complement activation (GO:0045916)2.27334017
161embryonic forelimb morphogenesis (GO:0035115)2.26831872
162regulation of keratinocyte proliferation (GO:0010837)2.26692627
163glomerulus development (GO:0032835)2.26233462
164peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.26212589
165negative regulation of homotypic cell-cell adhesion (GO:0034111)2.25549661
166wound healing, spreading of epidermal cells (GO:0035313)2.25278743
167cell differentiation involved in kidney development (GO:0061005)2.24420721
168mesenchymal cell development (GO:0014031)2.22363281
169positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.20551518
170regulation of male gonad development (GO:2000018)2.20195328
171cell proliferation in forebrain (GO:0021846)2.19013317
172lymphangiogenesis (GO:0001946)2.18827915
173embryonic skeletal joint morphogenesis (GO:0060272)2.17704530
174positive regulation of smooth muscle cell migration (GO:0014911)2.17511389
175facial nerve structural organization (GO:0021612)2.17506266
176positive regulation of fat cell differentiation (GO:0045600)2.17048705
177bone remodeling (GO:0046849)2.16724819
178face morphogenesis (GO:0060325)2.16527718
179activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.16063559
180positive regulation of cellular amide metabolic process (GO:0034250)2.15365594
181cellular response to vitamin D (GO:0071305)2.15122897
182regulation of mesenchymal cell proliferation (GO:0010464)2.14333977
183regulation of mononuclear cell migration (GO:0071675)2.13711209
184extracellular matrix organization (GO:0030198)2.13684551
185extracellular structure organization (GO:0043062)2.12896290
186endodermal cell differentiation (GO:0035987)2.12079251
187detection of other organism (GO:0098543)2.11027946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* GBX2_23144817_ChIP-Seq_PC3_Human3.66818659
2SMAD_19615063_ChIP-ChIP_OVARY_Human2.55273852
3EZH2_22144423_ChIP-Seq_EOC_Human2.55254432
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.49474207
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.44034875
6* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38058365
7SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.21911015
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.18656864
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16747473
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.13316090
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11532605
12* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10277688
13* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.99247658
14PCGF2_27294783_Chip-Seq_NPCs_Mouse1.98893762
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98672130
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93385588
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90843298
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90307268
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87930169
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87728787
21* FLI1_27457419_Chip-Seq_LIVER_Mouse1.84097616
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83588214
23* NFE2_27457419_Chip-Seq_LIVER_Mouse1.82126639
24* PIAS1_25552417_ChIP-Seq_VCAP_Human1.80952271
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79856304
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78759494
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77784426
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77707550
29ZNF274_21170338_ChIP-Seq_K562_Hela1.76615975
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76323539
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.75789879
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72987402
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72987402
34TBX3_20139965_ChIP-Seq_ESCs_Mouse1.72791842
35TBX3_20139965_ChIP-Seq_MESCs_Mouse1.71820851
36P300_19829295_ChIP-Seq_ESCs_Human1.69609258
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.69228320
38TP53_18474530_ChIP-ChIP_U2OS_Human1.68568062
39* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68094456
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.67871956
41* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.65648452
42* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65643210
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64928533
44* EZH2_27294783_Chip-Seq_NPCs_Mouse1.63255403
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.63187077
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62506823
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61382181
48AR_21572438_ChIP-Seq_LNCaP_Human1.61038360
49* NANOG_18555785_Chip-Seq_ESCs_Mouse1.60743558
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57878969
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56942583
52SMAD4_21799915_ChIP-Seq_A2780_Human1.54279239
53* E2F1_18555785_Chip-Seq_ESCs_Mouse1.53561348
54* P53_22387025_ChIP-Seq_ESCs_Mouse1.52577388
55* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.50385357
56* CJUN_26792858_Chip-Seq_BT549_Human1.50189085
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47734252
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.47461003
59IGF1R_20145208_ChIP-Seq_DFB_Human1.46206820
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.45878877
61* ELK1_19687146_ChIP-ChIP_HELA_Human1.44397226
62* STAT3_18555785_Chip-Seq_ESCs_Mouse1.43595115
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41996518
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41693849
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39986555
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.39702296
67* CMYC_18555785_Chip-Seq_ESCs_Mouse1.39695524
68* NMYC_18555785_Chip-Seq_ESCs_Mouse1.38886773
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38372652
70CBP_20019798_ChIP-Seq_JUKART_Human1.37662587
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37662587
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36821589
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36613731
74* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.35985721
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35656172
76VDR_22108803_ChIP-Seq_LS180_Human1.33025920
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32161958
78* SOX2_18555785_Chip-Seq_ESCs_Mouse1.31662643
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.30549373
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30066042
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29801589
82FUS_26573619_Chip-Seq_HEK293_Human1.29650673
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.29577951
84* P300_18555785_Chip-Seq_ESCs_Mouse1.29272959
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29162462
86* OCT4_18555785_Chip-Seq_ESCs_Mouse1.29028049
87WT1_19549856_ChIP-ChIP_CCG9911_Human1.27898977
88ER_23166858_ChIP-Seq_MCF-7_Human1.26807465
89DROSHA_22980978_ChIP-Seq_HELA_Human1.26550374
90EWS_26573619_Chip-Seq_HEK293_Human1.26291115
91* PU1_27457419_Chip-Seq_LIVER_Mouse1.25755280
92* ZFX_18555785_Chip-Seq_ESCs_Mouse1.25099845
93SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.24717682
94MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24465654
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23518185
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22855413
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.22470472
98TP63_17297297_ChIP-ChIP_HaCaT_Human1.22354744
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22061703
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.21262461
101STAT3_23295773_ChIP-Seq_U87_Human1.20931033
102RNF2_27304074_Chip-Seq_NSC_Mouse1.20483904
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19985951
104TAF15_26573619_Chip-Seq_HEK293_Human1.19862199
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19627875
106* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19385251
107* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19385251
108* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.18909927
109TP53_16413492_ChIP-PET_HCT116_Human1.18860654
110* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17448380
111* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17431248
112SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17106127
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.16888549
114* CRX_20693478_ChIP-Seq_RETINA_Mouse1.16567171
115* KLF4_18555785_Chip-Seq_ESCs_Mouse1.16283386
116AHR_22903824_ChIP-Seq_MCF-7_Human1.16108537
117* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14819367
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14662959
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13971817
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13886100
121* CTCF_18555785_Chip-Seq_ESCs_Mouse1.12677883
122* AR_25329375_ChIP-Seq_VCAP_Human1.12368028
123* RUNX2_22187159_ChIP-Seq_PCA_Human1.12346700
124STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12221341
125POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11753271
126SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11650728
127TCF4_23295773_ChIP-Seq_U87_Human1.11185756
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10475008
129P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09734474
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08335005
131YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08300451
132FLI1_21867929_ChIP-Seq_TH2_Mouse1.06987569
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06735331
134CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03481247
135JUN_21703547_ChIP-Seq_K562_Human0.99981871
136* SOX9_26525672_Chip-Seq_HEART_Mouse0.99867135
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99681873
138TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97370649
139KDM2B_26808549_Chip-Seq_REH_Human0.96860576
140CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95634891
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94226808
142PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91920869
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.91760301
144NANOG_19829295_ChIP-Seq_ESCs_Human0.89592877

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.25932011
2MP0005503_abnormal_tendon_morphology5.65191215
3MP0005275_abnormal_skin_tensile4.74304518
4MP0002638_abnormal_pupillary_reflex4.05786747
5MP0004858_abnormal_nervous_system3.35649510
6MP0005171_absent_coat_pigmentation3.13977348
7MP0008004_abnormal_stomach_pH3.05622083
8MP0005257_abnormal_intraocular_pressure2.92594697
9MP0001958_emphysema2.85166267
10MP0003279_aneurysm2.83456674
11MP0004859_abnormal_synaptic_plasticity2.66807613
12MP0001188_hyperpigmentation2.65767554
13MP0009384_cardiac_valve_regurgitation2.43516945
14MP0002090_abnormal_vision2.40751294
15MP0000566_synostosis2.36114313
16MP0003878_abnormal_ear_physiology2.26314184
17MP0005377_hearing/vestibular/ear_phenot2.26314184
18MP0003136_yellow_coat_color2.12928994
19MP0003941_abnormal_skin_development2.08408466
20MP0005508_abnormal_skeleton_morphology1.99573983
21MP0004133_heterotaxia1.99179950
22MP0010234_abnormal_vibrissa_follicle1.93780327
23MP0005248_abnormal_Harderian_gland1.86928390
24MP0002060_abnormal_skin_morphology1.85130895
25MP0000778_abnormal_nervous_system1.78143292
26MP0009250_abnormal_appendicular_skeleto1.77941883
27MP0000579_abnormal_nail_morphology1.74386578
28MP0005623_abnormal_meninges_morphology1.73541859
29MP0010386_abnormal_urinary_bladder1.72443008
30MP0002108_abnormal_muscle_morphology1.69863989
31MP0004272_abnormal_basement_membrane1.69281687
32MP0001984_abnormal_olfaction1.67180035
33MP0003045_fibrosis1.62575500
34MP0000751_myopathy1.60255528
35MP0002102_abnormal_ear_morphology1.57874065
36MP0006072_abnormal_retinal_apoptosis1.53349454
37MP0002254_reproductive_system_inflammat1.51449645
38MP0005174_abnormal_tail_pigmentation1.50115840
39MP0000383_abnormal_hair_follicle1.48080092
40MP0003385_abnormal_body_wall1.47628115
41MP0001293_anophthalmia1.45282999
42MP0000767_abnormal_smooth_muscle1.40847030
43MP0003011_delayed_dark_adaptation1.40060203
44MP0003724_increased_susceptibility_to1.39441875
45MP0001542_abnormal_bone_strength1.34534348
46MP0002127_abnormal_cardiovascular_syste1.34398094
47MP0004134_abnormal_chest_morphology1.33433320
48MP0003122_maternal_imprinting1.31493052
49MP0002938_white_spotting1.29939079
50MP0005390_skeleton_phenotype1.29927751
51MP0000569_abnormal_digit_pigmentation1.27882884
52MP0000049_abnormal_middle_ear1.26258890
53MP0005187_abnormal_penis_morphology1.26183010
54MP0002933_joint_inflammation1.25227063
55MP0002998_abnormal_bone_remodeling1.23928882
56MP0005408_hypopigmentation1.23768311
57MP0005646_abnormal_pituitary_gland1.21955545
58MP0001486_abnormal_startle_reflex1.20136971
59MP0005253_abnormal_eye_physiology1.17495573
60MP0005645_abnormal_hypothalamus_physiol1.16557231
61MP0002295_abnormal_pulmonary_circulatio1.15803464
62MP0001346_abnormal_lacrimal_gland1.14914933
63MP0001879_abnormal_lymphatic_vessel1.14366082
64MP0002115_abnormal_skeleton_extremities1.14241885
65MP0003186_abnormal_redox_activity1.13943200
66MP0000163_abnormal_cartilage_morphology1.13619293
67MP0000538_abnormal_urinary_bladder1.12781359
68MP0005367_renal/urinary_system_phenotyp1.11607587
69MP0000516_abnormal_urinary_system1.11607587
70MP0002249_abnormal_larynx_morphology1.11447761
71MP0002168_other_aberrant_phenotype1.11350920
72MP0005409_darkened_coat_color1.10916782
73MP0006292_abnormal_olfactory_placode1.10186084
74MP0000749_muscle_degeneration1.09145633
75MP0008775_abnormal_heart_ventricle1.08844718
76MP0002282_abnormal_trachea_morphology1.08239376
77MP0000762_abnormal_tongue_morphology1.06428098
78MP0002277_abnormal_respiratory_mucosa1.05972968
79MP0010368_abnormal_lymphatic_system1.04810195
80MP0002095_abnormal_skin_pigmentation1.04201790
81MP0001177_atelectasis1.02120630
82MP0002009_preneoplasia1.01435660
83MP0000920_abnormal_myelination1.00560905
84MP0002109_abnormal_limb_morphology1.00060547
85MP0002735_abnormal_chemical_nociception0.99582987
86MP0001963_abnormal_hearing_physiology0.99084041
87MP0002113_abnormal_skeleton_development0.98571389
88MP0004484_altered_response_of0.97533279
89MP0003942_abnormal_urinary_system0.97529734
90MP0002896_abnormal_bone_mineralization0.96976733
91MP0005220_abnormal_exocrine_pancreas0.96518097
92MP0003567_abnormal_fetal_cardiomyocyte0.96450552
93MP0000015_abnormal_ear_pigmentation0.95750768
94MP0009697_abnormal_copulation0.94425580
95MP0010329_abnormal_lipoprotein_level0.93436107
96MP0002133_abnormal_respiratory_system0.92630341
97MP0005388_respiratory_system_phenotype0.92630341
98MP0000462_abnormal_digestive_system0.92204932
99MP0000955_abnormal_spinal_cord0.91787914
100MP0002177_abnormal_outer_ear0.91700883
101MP0002116_abnormal_craniofacial_bone0.89884084
102MP0000427_abnormal_hair_cycle0.89706273
103MP0004270_analgesia0.88979503
104MP0000372_irregular_coat_pigmentation0.88739949
105MP0002736_abnormal_nociception_after0.88514410
106MP0006054_spinal_hemorrhage0.88064622
107MP0003566_abnormal_cell_adhesion0.87775042
108MP0001299_abnormal_eye_distance/0.87654347
109MP0002653_abnormal_ependyma_morphology0.87517376
110MP0003755_abnormal_palate_morphology0.86569570
111MP0001529_abnormal_vocalization0.85606249
112MP0010030_abnormal_orbit_morphology0.84446278
113MP0002233_abnormal_nose_morphology0.84443596
114MP0005164_abnormal_response_to0.84290649
115MP0000343_altered_response_to0.84094547
116MP0005595_abnormal_vascular_smooth0.83934649
117MP0004147_increased_porphyrin_level0.83779819
118MP0010352_gastrointestinal_tract_polyps0.82465565
119MP0000647_abnormal_sebaceous_gland0.80631178
120MP0009764_decreased_sensitivity_to0.80534086
121MP0005391_vision/eye_phenotype0.79742156
122MP0001661_extended_life_span0.79250560
123MP0003879_abnormal_hair_cell0.78558138
124MP0004019_abnormal_vitamin_homeostasis0.76504731
125MP0000026_abnormal_inner_ear0.76275451
126MP0001270_distended_abdomen0.76049439
127MP0000432_abnormal_head_morphology0.75274614
128MP0003937_abnormal_limbs/digits/tail_de0.75006594
129MP0004883_abnormal_blood_vessel0.74669015
130MP0001533_abnormal_skeleton_physiology0.73423096
131MP0001968_abnormal_touch/_nociception0.72870663
132MP0003121_genomic_imprinting0.72763521
133MP0005197_abnormal_uvea_morphology0.71808133
134MP0010678_abnormal_skin_adnexa0.71504096
135MP0000681_abnormal_thyroid_gland0.71008934
136MP0003091_abnormal_cell_migration0.70150466
137MP0002734_abnormal_mechanical_nocicepti0.69413622
138MP0002932_abnormal_joint_morphology0.68709950
139MP0005023_abnormal_wound_healing0.68426170
140MP0001915_intracranial_hemorrhage0.67783365
141MP0004742_abnormal_vestibular_system0.67768248
142MP0005647_abnormal_sex_gland0.67572179
143MP0000428_abnormal_craniofacial_morphol0.67455795
144MP0000534_abnormal_ureter_morphology0.66980159
145MP0003795_abnormal_bone_structure0.66430004
146MP0002928_abnormal_bile_duct0.65778210
147MP0003935_abnormal_craniofacial_develop0.65459325
148MP0002876_abnormal_thyroid_physiology0.65445424
149MP0010771_integument_phenotype0.64570913
150MP0001286_abnormal_eye_development0.63212787
151MP0002128_abnormal_blood_circulation0.62756868
152MP0000465_gastrointestinal_hemorrhage0.61433490
153MP0001340_abnormal_eyelid_morphology0.60993563
154MP0002184_abnormal_innervation0.60609832
155MP0001324_abnormal_eye_pigmentation0.58794399
156MP0003936_abnormal_reproductive_system0.58532687
157MP0003634_abnormal_glial_cell0.57981110
158MP0003252_abnormal_bile_duct0.56610442
159MP0002909_abnormal_adrenal_gland0.54495534

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)5.28679112
2Follicular hyperkeratosis (HP:0007502)4.57235778
3Premature rupture of membranes (HP:0001788)4.28303990
4Aortic dissection (HP:0002647)3.95034945
5Aortic aneurysm (HP:0004942)3.73643026
6Protrusio acetabuli (HP:0003179)3.71770661
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.62033190
8Hypoplastic pelvis (HP:0008839)3.47319278
9Coronal craniosynostosis (HP:0004440)3.46224708
10Heterochromia iridis (HP:0001100)3.44748183
11Papilledema (HP:0001085)3.41001142
12Soft skin (HP:0000977)3.29213651
13Broad metatarsal (HP:0001783)3.28962244
14Atrophic scars (HP:0001075)3.27604463
15Mesomelia (HP:0003027)3.27334288
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.15633400
17Wide anterior fontanel (HP:0000260)3.11121516
18Chromsome breakage (HP:0040012)3.07929504
19Abnormal ciliary motility (HP:0012262)3.04472728
20Pulmonary artery stenosis (HP:0004415)3.02727305
21Exercise-induced muscle cramps (HP:0003710)2.95969099
22Ulnar claw (HP:0001178)2.95337889
23Asymmetry of the thorax (HP:0001555)2.92516127
24Bell-shaped thorax (HP:0001591)2.83850190
25Broad foot (HP:0001769)2.78028392
26Fragile skin (HP:0001030)2.77072493
27Pheochromocytoma (HP:0002666)2.76871662
28Proximal tubulopathy (HP:0000114)2.75160192
29Vascular tortuosity (HP:0004948)2.73451830
30Prostate neoplasm (HP:0100787)2.73109955
31Abnormal respiratory motile cilium physiology (HP:0012261)2.68783075
32Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.68436717
33Action tremor (HP:0002345)2.68336130
34Cutaneous melanoma (HP:0012056)2.67681613
35Absent/shortened dynein arms (HP:0200106)2.67306106
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.67306106
37Bladder diverticulum (HP:0000015)2.65700697
38Hyperglycinemia (HP:0002154)2.62081244
39Neonatal respiratory distress (HP:0002643)2.60783601
40Short 5th finger (HP:0009237)2.60569037
41Albinism (HP:0001022)2.60060243
42Conjunctival telangiectasia (HP:0000524)2.56568747
43Neonatal short-limb short stature (HP:0008921)2.55824130
44Blue irides (HP:0000635)2.54647072
45Large for gestational age (HP:0001520)2.54365585
46Abnormal eating behavior (HP:0100738)2.48662538
47Hammertoe (HP:0001765)2.44975059
48Abnormality of the anterior horn cell (HP:0006802)2.42851832
49Degeneration of anterior horn cells (HP:0002398)2.42851832
50Duplicated collecting system (HP:0000081)2.41523409
51Abnormality of dentin (HP:0010299)2.41222028
52Abnormality of glycolysis (HP:0004366)2.40323641
53Steppage gait (HP:0003376)2.39914126
54Increased serum pyruvate (HP:0003542)2.38379794
55Medial flaring of the eyebrow (HP:0010747)2.35372531
56Cervical subluxation (HP:0003308)2.35325744
57Abnormal finger flexion creases (HP:0006143)2.34901258
58Abnormality of the anterior chamber (HP:0000593)2.33480603
59Increased corneal curvature (HP:0100692)2.29743083
60Keratoconus (HP:0000563)2.29743083
61Spondylolisthesis (HP:0003302)2.29401333
62Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.29156649
63Degeneration of the lateral corticospinal tracts (HP:0002314)2.29156649
64White forelock (HP:0002211)2.28673277
65Febrile seizures (HP:0002373)2.28176465
66Corneal dystrophy (HP:0001131)2.27308866
67Abnormality of the renal collecting system (HP:0004742)2.26880853
68Neuroendocrine neoplasm (HP:0100634)2.26816072
69Absent phalangeal crease (HP:0006109)2.24944090
70Aplasia cutis congenita (HP:0001057)2.24685908
71Hepatoblastoma (HP:0002884)2.23633969
72Arterial tortuosity (HP:0005116)2.19754525
73Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.18943108
74Ankle contracture (HP:0006466)2.15903369
75Abnormality of incisor morphology (HP:0011063)2.15901697
76Congenital sensorineural hearing impairment (HP:0008527)2.15210685
77Adactyly (HP:0009776)2.13586856
78Patchy hypopigmentation of hair (HP:0011365)2.11583447
79Ketoacidosis (HP:0001993)2.11096122
80Scanning speech (HP:0002168)2.10836055
81Aplasia/Hypoplasia of the hallux (HP:0008362)2.09657914
82Renal cortical cysts (HP:0000803)2.08794113
83High anterior hairline (HP:0009890)2.08379933
84Postaxial hand polydactyly (HP:0001162)2.07987128
85Pancreatic fibrosis (HP:0100732)2.06988206
86Pancreatic cysts (HP:0001737)2.06735453
87Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.06678562
88Thyroiditis (HP:0100646)2.06418566
89Aortic regurgitation (HP:0001659)2.06232122
90Osteomalacia (HP:0002749)2.05323464
91Chronic hepatic failure (HP:0100626)2.05304454
92Alopecia of scalp (HP:0002293)2.02510486
93Hypoplasia of the iris (HP:0007676)2.02265912
94Intellectual disability, mild (HP:0001256)2.01095070
95Shallow orbits (HP:0000586)2.00243168
96Abnormal respiratory epithelium morphology (HP:0012253)1.99580963
97Abnormal respiratory motile cilium morphology (HP:0005938)1.99580963
98Wrist flexion contracture (HP:0001239)1.99561042
99Type 1 muscle fiber predominance (HP:0003803)1.99552385
100Abnormality of the nasal septum (HP:0000419)1.99220987
101Aplasia/Hypoplasia of the tongue (HP:0010295)1.98812446
102Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97811738
103Vertebral compression fractures (HP:0002953)1.97462269
104Congenital primary aphakia (HP:0007707)1.97308816
105Insidious onset (HP:0003587)1.96919946
106Termporal pattern (HP:0011008)1.96919946
107Aortic valve stenosis (HP:0001650)1.95516075
108Absent frontal sinuses (HP:0002688)1.94667289
109Gait imbalance (HP:0002141)1.94308580
110Abnormality of glycine metabolism (HP:0010895)1.93603884
111Abnormality of serine family amino acid metabolism (HP:0010894)1.93603884
112Septo-optic dysplasia (HP:0100842)1.91898969
113Morphological abnormality of the middle ear (HP:0008609)1.90934662
114Dilatation of the ascending aorta (HP:0005111)1.90874022
115Abnormality of molar (HP:0011077)1.90617501
116Abnormality of molar morphology (HP:0011070)1.90617501
117True hermaphroditism (HP:0010459)1.90348610
118Spinal rigidity (HP:0003306)1.88383865
119Hypokinesia (HP:0002375)1.87505770
120Distal arthrogryposis (HP:0005684)1.86791800
121Tubulointerstitial abnormality (HP:0001969)1.86587024
122Bicornuate uterus (HP:0000813)1.85807461
123Upper limb muscle weakness (HP:0003484)1.85446321
124Bifid tongue (HP:0010297)1.85426712
125Renal hypoplasia (HP:0000089)1.83624800
126Myelomeningocele (HP:0002475)1.81724106
127Wormian bones (HP:0002645)1.80706166
128Craniofacial hyperostosis (HP:0004493)1.80440275
129Tetraparesis (HP:0002273)1.80232094
130Syringomyelia (HP:0003396)1.80138350
131Spinal cord lesions (HP:0100561)1.80138350
132Cerebral aneurysm (HP:0004944)1.79094550
133Genital tract atresia (HP:0001827)1.77150194
134Increased CSF protein (HP:0002922)1.75992451
135Aplasia/Hypoplasia of the lens (HP:0008063)1.75427391
136Abnormality of the epiphyses of the hand (HP:0005924)1.74936745
137Distal lower limb muscle weakness (HP:0009053)1.74672153
138Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.73902905
139Microglossia (HP:0000171)1.72932440
140Bowel diverticulosis (HP:0005222)1.72809878
141Supernumerary nipples (HP:0002558)1.72000009
142Abnormal auditory evoked potentials (HP:0006958)1.71660676
143Optic neuritis (HP:0100653)1.71026379
144Retrobulbar optic neuritis (HP:0100654)1.71026379
145Aplasia/Hypoplasia of the clavicles (HP:0006710)1.70648545
146Deep philtrum (HP:0002002)1.68969921
147Flat cornea (HP:0007720)1.68751460
148Nephronophthisis (HP:0000090)1.68482833
149Abnormality of the renal medulla (HP:0100957)1.68392043
150Cranial hyperostosis (HP:0004437)1.66671642
151Postaxial foot polydactyly (HP:0001830)1.66174179
152Biconcave vertebral bodies (HP:0004586)1.65038396
153Abnormal delivery (HP:0001787)1.64693250
154Narrow nasal bridge (HP:0000446)1.63288414
155Femoral bowing (HP:0002980)1.63190212
156Blue sclerae (HP:0000592)1.60966357
157Abnormality of the right ventricle (HP:0001707)1.60713407
158Tibial bowing (HP:0002982)1.59761940
159Slender build (HP:0001533)1.59476335
160Distal lower limb amyotrophy (HP:0008944)1.58056657
161Submucous cleft hard palate (HP:0000176)1.57820895
162Overgrowth (HP:0001548)1.57323723
163Renal dysplasia (HP:0000110)1.56415210
164Tubulointerstitial nephritis (HP:0001970)1.56170113
165Peritonitis (HP:0002586)1.55137666
166Limited hip movement (HP:0008800)1.54690732
167Orchitis (HP:0100796)1.53021296
168Abnormality of primary teeth (HP:0006481)1.52696029
169Rhinitis (HP:0012384)1.52304405
170Occipital encephalocele (HP:0002085)1.51782040
171Atelectasis (HP:0100750)1.51661945
172Congenital hepatic fibrosis (HP:0002612)1.51557599
173Fibular hypoplasia (HP:0003038)1.50665407
174Onycholysis (HP:0001806)1.50461573
175Hypoplastic ischia (HP:0003175)1.50325218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.21485740
2NTRK23.93231544
3BCKDK3.66295141
4ZAK3.22834941
5EPHA33.05270623
6MAP3K42.98781175
7MAP4K22.90597573
8SIK32.80167096
9DDR22.61753429
10TNIK2.47911916
11LATS12.46510991
12EIF2AK22.33183723
13INSRR2.19186833
14IRAK32.05952534
15SIK11.99260611
16EIF2AK31.91678395
17NUAK11.90953300
18MAP3K141.86973054
19MARK11.81188746
20FRK1.77596422
21STK391.76586166
22TXK1.74041457
23CSNK1G21.73928038
24TRPM71.70416385
25ERBB31.67553355
26TGFBR21.66197271
27MYLK1.65957174
28LATS21.65374217
29STK38L1.65008179
30PIK3CG1.57807067
31TRIM281.57593958
32CSNK1A1L1.52875742
33PAK61.49447182
34PINK11.39944590
35MKNK21.39482586
36CSNK1G31.35787092
37BMPR1B1.35084435
38TIE11.31908492
39GRK11.30770795
40TEC1.30765774
41CDK81.30631416
42STK161.27472977
43YES11.27392192
44ADRBK21.27192165
45CSNK1G11.25013494
46PIK3CA1.23878466
47EPHB21.23771065
48NEK61.22746825
49SGK21.20198864
50AKT31.17415357
51BRD41.17131100
52MOS1.15277800
53WNK31.10674424
54PRPF4B1.10138117
55TESK11.09985703
56MUSK1.06274574
57PLK21.05710832
58IRAK41.04176276
59FER1.03794056
60JAK11.03337845
61NTRK31.03231617
62PRKCE1.02808525
63STK31.02175241
64CDK31.01188614
65IRAK10.99955405
66PDGFRA0.98623745
67MAP2K70.98387227
68BMPR20.96939704
69DYRK20.95686759
70MKNK10.93720130
71MAPK130.93597291
72NLK0.92864962
73SIK20.92229114
74PKN10.88583370
75CDK60.88451512
76STK380.86908831
77DMPK0.84174875
78EPHB10.80797093
79WNK40.78111269
80TTN0.75615765
81TAOK20.75544755
82JAK30.71443876
83KIT0.70274346
84GRK70.69416784
85ERBB20.68057114
86RIPK10.67839150
87CAMK1D0.64946347
88CLK10.64503941
89IKBKB0.64263391
90PTK20.62579625
91STK240.62576400
92NEK90.62112703
93GSK3A0.61845540
94ROCK20.60644987
95CDC42BPA0.59892439
96MAPK70.59618154
97BCR0.59147668
98SGK30.58933298
99ROCK10.58729218
100CAMK2D0.58076191
101PAK20.56088154
102BLK0.55512528
103CDK190.54975123
104ABL20.54299704
105SGK4940.54060470
106SGK2230.54060470
107FGR0.53972967
108TNK20.53934802
109CAMK2A0.51298744
110MAPK150.51291623
111PRKG10.49711652
112CHUK0.49710616
113NTRK10.48979180
114CDK50.48638152
115FGFR10.47785447
116PRKD20.46388289
117ERBB40.46357317
118LIMK10.46333198
119DYRK30.46125462
120PAK30.44004311
121RPS6KA40.43716625
122PRKAA20.43288196
123MAP2K40.43010976
124PTK2B0.42179042
125EIF2AK10.42155895
126ADRBK10.42143556
127OBSCN0.42002612
128FGFR30.41026394
129IKBKE0.40276725
130EPHA40.39911468
131IGF1R0.38969804
132CAMK1G0.38892959
133CAMK10.38756382
134SGK10.38470227
135IRAK20.36182393
136INSR0.35665325
137MST40.35614494
138PRKD10.35521688
139CAMK2G0.33935513
140CAMK2B0.33661878
141PRKACB0.33179132
142ABL10.32454419
143FGFR20.32318835
144SRC0.32300069
145PIM20.31664999
146WNK10.31229808
147MARK30.30251620
148CDK140.29224063
149CDK180.28831045
150FLT30.27783387
151PRKCG0.26914547
152TGFBR10.26372246

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.69437521
2Steroid biosynthesis_Homo sapiens_hsa001003.87748265
3Protein export_Homo sapiens_hsa030603.46949695
4Propanoate metabolism_Homo sapiens_hsa006403.19411934
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.10950058
6ECM-receptor interaction_Homo sapiens_hsa045122.92808255
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.79704716
8Butanoate metabolism_Homo sapiens_hsa006502.36327608
9Malaria_Homo sapiens_hsa051442.32505804
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.17180525
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.15275759
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.14140163
13Fatty acid elongation_Homo sapiens_hsa000622.11544690
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.87938034
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.82440411
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74153766
17Fatty acid metabolism_Homo sapiens_hsa012121.73812913
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.73026696
19Rheumatoid arthritis_Homo sapiens_hsa053231.71205965
20Peroxisome_Homo sapiens_hsa041461.70523695
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.68313865
22Protein digestion and absorption_Homo sapiens_hsa049741.67053822
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.64840844
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57243955
25Focal adhesion_Homo sapiens_hsa045101.52661423
26Nitrogen metabolism_Homo sapiens_hsa009101.50978091
27Arachidonic acid metabolism_Homo sapiens_hsa005901.50603362
28Dilated cardiomyopathy_Homo sapiens_hsa054141.48100401
29Autoimmune thyroid disease_Homo sapiens_hsa053201.44385878
30TNF signaling pathway_Homo sapiens_hsa046681.43626591
31Fatty acid degradation_Homo sapiens_hsa000711.42269874
32Hematopoietic cell lineage_Homo sapiens_hsa046401.40336278
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39385209
34Pyruvate metabolism_Homo sapiens_hsa006201.37667896
35Nicotine addiction_Homo sapiens_hsa050331.36886078
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34205057
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31653775
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30575082
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26908031
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26424091
41Lysine degradation_Homo sapiens_hsa003101.25328685
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.24184407
43Ovarian steroidogenesis_Homo sapiens_hsa049131.22901031
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22851493
45TGF-beta signaling pathway_Homo sapiens_hsa043501.22349577
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22058919
47Leishmaniasis_Homo sapiens_hsa051401.21188124
48Melanoma_Homo sapiens_hsa052181.19457248
49Glutathione metabolism_Homo sapiens_hsa004801.18934744
50Basal cell carcinoma_Homo sapiens_hsa052171.18695233
51Fanconi anemia pathway_Homo sapiens_hsa034601.18503317
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.17472163
53Phagosome_Homo sapiens_hsa041451.16406278
54Graft-versus-host disease_Homo sapiens_hsa053321.16179613
55Small cell lung cancer_Homo sapiens_hsa052221.15991733
56PI3K-Akt signaling pathway_Homo sapiens_hsa041511.14577072
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.14394780
58Axon guidance_Homo sapiens_hsa043601.13990655
59Amoebiasis_Homo sapiens_hsa051461.13133235
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11150925
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08065032
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07520010
63Allograft rejection_Homo sapiens_hsa053301.06775707
64Sphingolipid metabolism_Homo sapiens_hsa006001.03718430
65Taste transduction_Homo sapiens_hsa047421.01912402
66Vitamin B6 metabolism_Homo sapiens_hsa007500.98917074
67African trypanosomiasis_Homo sapiens_hsa051430.97965605
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96418268
69Morphine addiction_Homo sapiens_hsa050320.94642777
70Collecting duct acid secretion_Homo sapiens_hsa049660.94348235
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92704676
72Arginine and proline metabolism_Homo sapiens_hsa003300.91591584
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89032960
74MicroRNAs in cancer_Homo sapiens_hsa052060.88875713
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.88310859
76Tryptophan metabolism_Homo sapiens_hsa003800.88096607
77Proteoglycans in cancer_Homo sapiens_hsa052050.87266920
78Histidine metabolism_Homo sapiens_hsa003400.86678136
79Wnt signaling pathway_Homo sapiens_hsa043100.85945469
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85568654
81Calcium signaling pathway_Homo sapiens_hsa040200.85421307
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85227520
83Complement and coagulation cascades_Homo sapiens_hsa046100.85188285
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84910416
85Measles_Homo sapiens_hsa051620.83987465
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83271259
87Adherens junction_Homo sapiens_hsa045200.83084973
88Vitamin digestion and absorption_Homo sapiens_hsa049770.82445515
89Pathways in cancer_Homo sapiens_hsa052000.79624252
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79561086
91Chemical carcinogenesis_Homo sapiens_hsa052040.78857298
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.78048142
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76889622
94Serotonergic synapse_Homo sapiens_hsa047260.76687131
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76523451
96Toxoplasmosis_Homo sapiens_hsa051450.76515751
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76356708
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.75877513
99Circadian rhythm_Homo sapiens_hsa047100.75831522
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75507738
101Osteoclast differentiation_Homo sapiens_hsa043800.74834210
102PPAR signaling pathway_Homo sapiens_hsa033200.74497441
103Ras signaling pathway_Homo sapiens_hsa040140.72632093
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72592820
105Hedgehog signaling pathway_Homo sapiens_hsa043400.72129403
106Tuberculosis_Homo sapiens_hsa051520.71951247
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71807501
108Biosynthesis of amino acids_Homo sapiens_hsa012300.71246825
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71208782
110Hippo signaling pathway_Homo sapiens_hsa043900.69225110
111Other glycan degradation_Homo sapiens_hsa005110.69177482
112Prostate cancer_Homo sapiens_hsa052150.68880422
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68456821
114Pertussis_Homo sapiens_hsa051330.67423832
115Vibrio cholerae infection_Homo sapiens_hsa051100.66987518
116Rap1 signaling pathway_Homo sapiens_hsa040150.66652169
117Caffeine metabolism_Homo sapiens_hsa002320.66131069
118Phototransduction_Homo sapiens_hsa047440.65618496
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64983307
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64164853
121Asthma_Homo sapiens_hsa053100.63810355
122Olfactory transduction_Homo sapiens_hsa047400.63299673
123Fatty acid biosynthesis_Homo sapiens_hsa000610.63053405
124cAMP signaling pathway_Homo sapiens_hsa040240.63026656
125Thyroid hormone synthesis_Homo sapiens_hsa049180.62495026
126Tight junction_Homo sapiens_hsa045300.62465945
127N-Glycan biosynthesis_Homo sapiens_hsa005100.61768230
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60810252
129Salmonella infection_Homo sapiens_hsa051320.57891670
130Ether lipid metabolism_Homo sapiens_hsa005650.57830509
131ABC transporters_Homo sapiens_hsa020100.57433594
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55107771
133Carbon metabolism_Homo sapiens_hsa012000.55090565
134Influenza A_Homo sapiens_hsa051640.54776799
135Metabolic pathways_Homo sapiens_hsa011000.54688909
136Herpes simplex infection_Homo sapiens_hsa051680.54581243
137Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53397974
138Oxidative phosphorylation_Homo sapiens_hsa001900.52755155
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.51558371
140Fructose and mannose metabolism_Homo sapiens_hsa000510.51287564
141Chemokine signaling pathway_Homo sapiens_hsa040620.50708381
142MAPK signaling pathway_Homo sapiens_hsa040100.50592227
143Retinol metabolism_Homo sapiens_hsa008300.49427154
144Viral myocarditis_Homo sapiens_hsa054160.48676058
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48040889
146Circadian entrainment_Homo sapiens_hsa047130.47762865
147Non-homologous end-joining_Homo sapiens_hsa034500.47683784
148Pancreatic cancer_Homo sapiens_hsa052120.47424722
149Notch signaling pathway_Homo sapiens_hsa043300.47012660
150Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46678190
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45497221
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45400032
153alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45145331
154Galactose metabolism_Homo sapiens_hsa000520.44593645
155beta-Alanine metabolism_Homo sapiens_hsa004100.41707892
156Parkinsons disease_Homo sapiens_hsa050120.40681035
157Synaptic vesicle cycle_Homo sapiens_hsa047210.39416821
158Glutamatergic synapse_Homo sapiens_hsa047240.38922696
159Basal transcription factors_Homo sapiens_hsa030220.37949029
160Glycerolipid metabolism_Homo sapiens_hsa005610.37023725
161Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36740568
162Dopaminergic synapse_Homo sapiens_hsa047280.36286550
163Sulfur relay system_Homo sapiens_hsa041220.35931918
164Folate biosynthesis_Homo sapiens_hsa007900.34627356
165Mineral absorption_Homo sapiens_hsa049780.33921463
166Lysosome_Homo sapiens_hsa041420.30352049
167Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29804004

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