PI3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)9.48111593
2regulation of water loss via skin (GO:0033561)9.17835186
3desmosome organization (GO:0002934)7.98471000
4detection of bacterium (GO:0016045)7.75476600
5detection of other organism (GO:0098543)7.55643434
6epidermal cell differentiation (GO:0009913)7.21459864
7peptide cross-linking (GO:0018149)7.08395146
8multicellular organismal water homeostasis (GO:0050891)5.91527798
9lipoxygenase pathway (GO:0019372)5.85333638
10epidermis development (GO:0008544)5.60085672
11bundle of His cell to Purkinje myocyte communication (GO:0086069)5.48929688
12molting cycle (GO:0042303)5.43855536
13hair cycle (GO:0042633)5.43855536
14keratinocyte proliferation (GO:0043616)5.38799427
15detection of external biotic stimulus (GO:0098581)5.32479198
16hemidesmosome assembly (GO:0031581)5.25002657
17water homeostasis (GO:0030104)5.21646297
18long-chain fatty acid biosynthetic process (GO:0042759)5.17291896
19skin morphogenesis (GO:0043589)4.94337651
20positive regulation of monocyte chemotaxis (GO:0090026)4.80331159
21regulation of natural killer cell differentiation (GO:0032823)4.78601956
22phosphatidylinositol acyl-chain remodeling (GO:0036149)4.76557225
23linoleic acid metabolic process (GO:0043651)4.63694268
24detection of biotic stimulus (GO:0009595)4.56327761
25phosphatidylserine acyl-chain remodeling (GO:0036150)4.44723503
26sequestering of metal ion (GO:0051238)4.39468175
27negative regulation of interferon-gamma production (GO:0032689)4.39276978
28positive regulation of T cell chemotaxis (GO:0010820)4.14023758
29regulation of T cell chemotaxis (GO:0010819)4.14023758
30negative regulation of interleukin-17 production (GO:0032700)4.13028478
31regulation of monocyte chemotaxis (GO:0090025)4.01629750
32gap junction assembly (GO:0016264)3.85031547
33phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.73531673
34intermediate filament organization (GO:0045109)3.61098054
35phosphatidylcholine acyl-chain remodeling (GO:0036151)3.59103980
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.57770537
37positive regulation by organism of defense response of other organism involved in symbiotic interact3.57770537
38modulation by symbiont of host immune response (GO:0052553)3.57770537
39positive regulation by symbiont of host defense response (GO:0052509)3.57770537
40modulation by symbiont of host defense response (GO:0052031)3.57770537
41modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.57770537
42surfactant homeostasis (GO:0043129)3.54206212
43intermediate filament cytoskeleton organization (GO:0045104)3.51802706
44phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.46113163
45leukocyte aggregation (GO:0070486)3.38962393
46response to peptidoglycan (GO:0032494)3.38516746
47intermediate filament-based process (GO:0045103)3.37756345
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.24843528
49leukocyte migration involved in inflammatory response (GO:0002523)3.22051301
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.15458128
51macrophage activation involved in immune response (GO:0002281)3.14095166
52positive regulation of granulocyte chemotaxis (GO:0071624)3.11242053
53negative regulation of interleukin-6 production (GO:0032715)3.08560933
54defense response to Gram-negative bacterium (GO:0050829)3.05959300
55complement activation, classical pathway (GO:0006958)3.05398157
56ectoderm development (GO:0007398)3.03407892
57negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.01906149
58negative regulation of cell killing (GO:0031342)3.01906149
59positive regulation of epidermis development (GO:0045684)2.99984518
60positive regulation of Cdc42 GTPase activity (GO:0043089)2.98765358
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98167798
62regulation of interleukin-17 production (GO:0032660)2.97709774
63positive regulation of T cell migration (GO:2000406)2.96612096
64detection of molecule of bacterial origin (GO:0032490)2.96566740
65germinal center formation (GO:0002467)2.95515627
66regulation of lymphocyte chemotaxis (GO:1901623)2.94397409
67neutrophil activation involved in immune response (GO:0002283)2.93570612
68antigen processing and presentation of endogenous antigen (GO:0019883)2.93180625
69regulation of T cell migration (GO:2000404)2.91854910
70phosphatidylserine metabolic process (GO:0006658)2.91704870
71positive regulation of cellular amide metabolic process (GO:0034250)2.91032617
72negative regulation of keratinocyte proliferation (GO:0010839)2.75714629
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.75529478
74epithelial cell differentiation involved in prostate gland development (GO:0060742)2.75063050
75complement activation (GO:0006956)2.74244156
76neutrophil activation (GO:0042119)2.73105242
77positive regulation of epidermal cell differentiation (GO:0045606)2.68958155
78negative regulation of interleukin-12 production (GO:0032695)2.67656897
79negative regulation of T cell mediated immunity (GO:0002710)2.67620210
80chemical homeostasis within a tissue (GO:0048875)2.67496537
81protein localization to endosome (GO:0036010)2.65416767
82regulation of interleukin-6 production (GO:0032675)2.60150145
83positive regulation of gamma-delta T cell activation (GO:0046645)2.59813759
84regulation of interferon-beta biosynthetic process (GO:0045357)2.56488521
85positive regulation of lymphocyte migration (GO:2000403)2.55665230
86granulocyte activation (GO:0036230)2.54962577
87negative regulation of toll-like receptor signaling pathway (GO:0034122)2.54681886
88defense response to fungus (GO:0050832)2.53452152
89lipopolysaccharide-mediated signaling pathway (GO:0031663)2.52494739
90antimicrobial humoral response (GO:0019730)2.49195214
91negative regulation of lymphocyte mediated immunity (GO:0002707)2.49122824
92alditol phosphate metabolic process (GO:0052646)2.48438881
93regulation of neuron projection regeneration (GO:0070570)2.46927095
94regulation of axon regeneration (GO:0048679)2.46927095
95ceramide biosynthetic process (GO:0046513)2.46534634
96response to muramyl dipeptide (GO:0032495)2.46093060
97regulation of lymphocyte migration (GO:2000401)2.45900174
98polyol transport (GO:0015791)2.44227313
99keratinization (GO:0031424)16.1748584
100establishment of skin barrier (GO:0061436)10.3410278

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.42065089
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.08137514
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.07489306
4P63_26484246_Chip-Seq_KERATINOCYTES_Human3.04220643
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.99087819
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.70260404
7* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.32510858
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.00403393
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00163300
10TP63_17297297_ChIP-ChIP_HaCaT_Human10.8188697
11SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.95998931
12SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.95998931
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.83658108
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80871018
15IRF8_21731497_ChIP-ChIP_J774_Mouse1.79284158
16RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72966539
17KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.69673176
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.67154312
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65418034
20MYB_21317192_ChIP-Seq_ERMYB_Mouse1.65189193
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60348899
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57626174
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.56692520
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55868494
25RACK7_27058665_Chip-Seq_MCF-7_Human1.52692736
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49389941
27EGR1_19032775_ChIP-ChIP_M12_Human1.49135731
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.48597139
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46071499
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45422458
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45053066
32ATF3_27146783_Chip-Seq_COLON_Human1.43651496
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.43511615
34SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39694992
35* LXR_22292898_ChIP-Seq_THP-1_Human1.38836456
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37397383
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37104290
38TCF7_22412390_ChIP-Seq_EML_Mouse1.36160276
39VDR_24763502_ChIP-Seq_THP-1_Human1.36032537
40TP63_22573176_ChIP-Seq_HFKS_Human1.35121455
41* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.31723062
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.30949846
43* SOX2_20726797_ChIP-Seq_SW620_Human1.30799074
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28888313
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28312417
46TP63_23658742_ChIP-Seq_EP156T_Human1.25482199
47VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24739364
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24717083
49VDR_21846776_ChIP-Seq_THP-1_Human1.23353450
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22421952
51BCOR_27268052_Chip-Seq_Bcells_Human1.21825896
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21260899
53KDM2B_26808549_Chip-Seq_DND41_Human1.19758192
54SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18429113
55SPI1_23127762_ChIP-Seq_K562_Human1.18053734
56MAF_26560356_Chip-Seq_TH1_Human1.17118716
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16933211
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15952583
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12499424
60SMC4_20622854_ChIP-Seq_HELA_Human1.11757302
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10989415
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10460393
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09791471
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08613266
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.07215689
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.06746696
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06739378
68BCL6_27268052_Chip-Seq_Bcells_Human1.05219944
69RUNX_20019798_ChIP-Seq_JUKART_Human1.04829874
70UBF1/2_26484160_Chip-Seq_HMECs_Human1.04265938
71UTX_26944678_Chip-Seq_JUKART_Human1.04076402
72BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.03685919
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.02839084
74FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01953526
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01852142
76KLF5_25053715_ChIP-Seq_YYC3_Human1.01841253
77E2F1_20622854_ChIP-Seq_HELA_Human1.00668235
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00284634
79ESR1_20079471_ChIP-ChIP_T-47D_Human0.99248906
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98783958
81GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98362847
82CLOCK_20551151_ChIP-Seq_293T_Human0.97316348
83SPI1_23547873_ChIP-Seq_NB4_Human0.96549447
84STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96119185
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95927681
86PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95818262
87PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94310954
88GATA1_19941826_ChIP-Seq_K562_Human0.93603636
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90818125
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90355109
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90287244
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87559836
93GATA2_19941826_ChIP-Seq_K562_Human0.86181678
94RXR_22158963_ChIP-Seq_LIVER_Mouse0.85266175
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85114217
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84422212
97P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.83812423
98GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83362963
99KDM2B_26808549_Chip-Seq_JURKAT_Human0.82845088
100KDM2B_26808549_Chip-Seq_K562_Human0.81993383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.55918553
2MP0000579_abnormal_nail_morphology5.42950413
3MP0010234_abnormal_vibrissa_follicle5.36014265
4MP0005275_abnormal_skin_tensile5.07222073
5MP0005501_abnormal_skin_physiology4.11153080
6MP0003453_abnormal_keratinocyte_physiol3.07752077
7MP0001216_abnormal_epidermal_layer2.87947091
8MP0003724_increased_susceptibility_to2.73149149
9MP0003191_abnormal_cellular_cholesterol2.71443546
10MP0003878_abnormal_ear_physiology2.60792690
11MP0005377_hearing/vestibular/ear_phenot2.60792690
12MP0004947_skin_inflammation2.55246952
13MP0004381_abnormal_hair_follicle2.44824258
14MP0000467_abnormal_esophagus_morphology2.41350268
15MP0004885_abnormal_endolymph2.39334580
16MP0002060_abnormal_skin_morphology2.31974528
17MP0003436_decreased_susceptibility_to2.30270959
18MP0004264_abnormal_extraembryonic_tissu2.29224175
19MP0010678_abnormal_skin_adnexa2.23823653
20MP0003941_abnormal_skin_development2.19385534
21MP0010771_integument_phenotype2.15451197
22MP0003705_abnormal_hypodermis_morpholog2.09063684
23MP0003303_peritoneal_inflammation2.02227076
24MP0005409_darkened_coat_color1.97256763
25MP0004782_abnormal_surfactant_physiolog1.91195412
26MP0000465_gastrointestinal_hemorrhage1.88101019
27MP0003566_abnormal_cell_adhesion1.84938557
28MP0002098_abnormal_vibrissa_morphology1.79636114
29MP0000377_abnormal_hair_follicle1.76783960
30MP0000383_abnormal_hair_follicle1.71061709
31MP0009931_abnormal_skin_appearance1.57888997
32MP0010352_gastrointestinal_tract_polyps1.51960974
33MP0000762_abnormal_tongue_morphology1.47190656
34MP0001851_eye_inflammation1.42480628
35MP0000685_abnormal_immune_system1.42450719
36MP0003300_gastrointestinal_ulcer1.39754721
37MP0005025_abnormal_response_to1.37919073
38MP0008260_abnormal_autophagy1.34342271
39MP0005023_abnormal_wound_healing1.30710405
40MP0009785_altered_susceptibility_to1.27198597
41MP0002419_abnormal_innate_immunity1.24629934
42MP0005387_immune_system_phenotype1.24545603
43MP0001790_abnormal_immune_system1.24545603
44MP0001533_abnormal_skeleton_physiology1.23194939
45MP0001800_abnormal_humoral_immune1.16836479
46MP0005000_abnormal_immune_tolerance1.13109035
47MP0008004_abnormal_stomach_pH1.10955301
48MP0010155_abnormal_intestine_physiology1.09525314
49MP0001191_abnormal_skin_condition1.09113377
50MP0002148_abnormal_hypersensitivity_rea1.03757269
51MP0000367_abnormal_coat/_hair1.02201185
52MP0004043_abnormal_pH_regulation1.01390495
53MP0002723_abnormal_immune_serum0.99134732
54MP0002452_abnormal_antigen_presenting0.97477028
55MP0001835_abnormal_antigen_presentation0.96923371
56MP0003763_abnormal_thymus_physiology0.94826191
57MP0009053_abnormal_anal_canal0.94751680
58MP0003828_pulmonary_edema0.93344226
59MP0001819_abnormal_immune_cell0.91610401
60MP0002420_abnormal_adaptive_immunity0.91332811
61MP0000858_altered_metastatic_potential0.90922200
62MP0005671_abnormal_response_to0.90503652
63MP0000427_abnormal_hair_cycle0.86496165
64MP0003075_altered_response_to0.86202953
65MP0002138_abnormal_hepatobiliary_system0.83891925
66MP0009333_abnormal_splenocyte_physiolog0.82258769
67MP0004858_abnormal_nervous_system0.79545567
68MP0001188_hyperpigmentation0.79315175
69MP0004185_abnormal_adipocyte_glucose0.77790654
70MP0003011_delayed_dark_adaptation0.75729044
71MP0005166_decreased_susceptibility_to0.75328591
72MP0005451_abnormal_body_composition0.72112594
73MP0001845_abnormal_inflammatory_respons0.71852347
74MP0006082_CNS_inflammation0.71260841
75MP0002277_abnormal_respiratory_mucosa0.70783783
76MP0003448_altered_tumor_morphology0.68495641
77MP0001243_abnormal_dermal_layer0.68374585
78MP0005164_abnormal_response_to0.64873086
79MP0002405_respiratory_system_inflammati0.62761287
80MP0009764_decreased_sensitivity_to0.62661760
81MP0003866_abnormal_defecation0.62377788
82MP0001784_abnormal_fluid_regulation0.60800649
83MP0000678_abnormal_parathyroid_gland0.60794040
84MP0005464_abnormal_platelet_physiology0.60172811
85MP0002095_abnormal_skin_pigmentation0.59862148
86MP0004510_myositis0.58710103
87MP0000566_synostosis0.58389732
88MP0000647_abnormal_sebaceous_gland0.55337709
89MP0003045_fibrosis0.55053345
90MP0009840_abnormal_foam_cell0.54112020
91MP0005388_respiratory_system_phenotype0.53974541
92MP0002133_abnormal_respiratory_system0.53974541
93MP0000716_abnormal_immune_system0.53805133
94MP0005390_skeleton_phenotype0.51859986
95MP0002877_abnormal_melanocyte_morpholog0.51790858
96MP0002006_tumorigenesis0.51525834
97MP0008469_abnormal_protein_level0.49391584
98MP0003315_abnormal_perineum_morphology0.47633015
99MP0009765_abnormal_xenobiotic_induced0.46077151
100MP0002998_abnormal_bone_remodeling0.45897691

Predicted human phenotypes

RankGene SetZ-score
1Palmoplantar hyperkeratosis (HP:0000972)7.94963518
2Increased IgE level (HP:0003212)7.91810325
3Palmar hyperkeratosis (HP:0010765)7.51747043
4Oral leukoplakia (HP:0002745)7.38908604
5Plantar hyperkeratosis (HP:0007556)7.01015204
6Onycholysis (HP:0001806)6.73651991
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.53318353
8Congenital ichthyosiform erythroderma (HP:0007431)6.42225354
9Erythroderma (HP:0001019)6.26446671
10Alopecia of scalp (HP:0002293)6.24827143
11Thick nail (HP:0001805)6.06362353
12Erythema (HP:0010783)4.95143752
13Corneal erosion (HP:0200020)4.89407195
14Parakeratosis (HP:0001036)4.87595100
15Gangrene (HP:0100758)4.51352291
16Hypotrichosis (HP:0001006)4.43002231
17Nail dystrophy (HP:0008404)4.25118041
18Right ventricular cardiomyopathy (HP:0011663)4.10848431
19Abnormality of the axillary hair (HP:0100134)4.09207348
20Abnormality of secondary sexual hair (HP:0009888)4.09207348
21Fragile nails (HP:0001808)4.02964969
22Ectropion (HP:0000656)3.93464290
23Pustule (HP:0200039)3.81738257
24Palmoplantar keratoderma (HP:0000982)3.66417032
25Hypohidrosis (HP:0000966)3.66416142
26Recurrent bacterial skin infections (HP:0005406)3.66207209
27Abnormal blistering of the skin (HP:0008066)3.52185267
28Eczematoid dermatitis (HP:0000976)3.49466971
29Urticaria (HP:0001025)3.32142118
30Milia (HP:0001056)3.22374851
31Keratoconjunctivitis sicca (HP:0001097)3.18570247
32Abnormality of placental membranes (HP:0011409)3.12120515
33Amniotic constriction ring (HP:0009775)3.12120515
34Woolly hair (HP:0002224)3.08197542
35Sparse eyelashes (HP:0000653)3.05824941
36Absent eyelashes (HP:0000561)2.94012110
37Lip pit (HP:0100267)2.90237196
38Follicular hyperkeratosis (HP:0007502)2.89818311
39Conjunctival hamartoma (HP:0100780)2.89149934
40Keratoconjunctivitis (HP:0001096)2.89080082
41Ridged nail (HP:0001807)2.73202660
42Absent hair (HP:0002298)2.69209396
43Pruritus (HP:0000989)2.66323722
44Hypergammaglobulinemia (HP:0010702)2.58108332
45Abnormality of the salivary glands (HP:0010286)2.55143592
46Sepsis (HP:0100806)2.42541498
47Multifactorial inheritance (HP:0001426)2.40326920
48Furrowed tongue (HP:0000221)2.39339243
49Orchitis (HP:0100796)2.36118034
50Skin ulcer (HP:0200042)2.33821382
51Blepharitis (HP:0000498)2.32164356
52Lack of skin elasticity (HP:0100679)2.31691643
53Autoamputation (HP:0001218)2.28658245
54Pili torti (HP:0003777)2.27099743
55Abnormality of macrophages (HP:0004311)2.27091146
56Myositis (HP:0100614)2.26934635
57Sparse scalp hair (HP:0002209)2.25615750
58Dehydration (HP:0001944)2.24143918
59Abnormal hair laboratory examination (HP:0003328)2.11900817
60Recurrent skin infections (HP:0001581)2.10335677
61Hyperhidrosis (HP:0000975)2.06079853
62Abnormality of nail color (HP:0100643)12.0427511
63Optic neuritis (HP:0100653)1.98316964
64Retrobulbar optic neuritis (HP:0100654)1.98316964
65Laryngomalacia (HP:0001601)1.96382786
66Recurrent abscess formation (HP:0002722)1.90645314
67Anonychia (HP:0001798)1.88382038
68Paralysis (HP:0003470)1.87024156
69Verrucae (HP:0200043)1.85095687
70Papilloma (HP:0012740)1.85095687
71Carious teeth (HP:0000670)1.84343083
72Segmental peripheral demyelination/remyelination (HP:0003481)1.81987916
73Brittle hair (HP:0002299)1.72601031
74Hamartoma of the eye (HP:0010568)1.70316455
75Xerostomia (HP:0000217)1.69686819
76Elevated erythrocyte sedimentation rate (HP:0003565)1.67771393
77Premature loss of primary teeth (HP:0006323)1.66289298
78Hypermelanotic macule (HP:0001034)1.64501182
79Corneal dystrophy (HP:0001131)1.61542474
80Abnormality of the fingernails (HP:0001231)1.60359489
81Gingivitis (HP:0000230)1.59597419
82Natal tooth (HP:0000695)1.55496215
83Recurrent corneal erosions (HP:0000495)1.53888622
84Dry skin (HP:0000958)1.52726345
85Atrophic scars (HP:0001075)1.49406375
86Slow-growing hair (HP:0002217)1.47810391
87Abnormality of hair growth rate (HP:0011363)1.47810391
88Malnutrition (HP:0004395)1.47651506
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.41377203
90Advanced eruption of teeth (HP:0006288)1.41254768
91Ventricular tachycardia (HP:0004756)1.40048473
92Melanocytic nevus (HP:0000995)1.37805200
93Stomatitis (HP:0010280)1.37446718
94Fine hair (HP:0002213)1.36283299
95Keratitis (HP:0000491)1.35222882
96Selective tooth agenesis (HP:0001592)1.34862735
97Abnormality of the neuromuscular junction (HP:0003398)1.34822095
98Fatigable weakness (HP:0003473)1.34822095
99Interstitial pulmonary disease (HP:0006530)1.34695623
100Skin rash (HP:0000988)1.34186229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.23991590
2EPHA23.36366263
3EPHB13.20453800
4MAP3K32.75489175
5IRAK42.63463699
6RIPK42.53959908
7IRAK32.46268889
8GRK62.43756161
9MAP4K12.30850637
10TAOK12.19337022
11CSK2.14734041
12MAP3K22.09843564
13MST1R2.09573749
14RIPK11.93039359
15BLK1.92608397
16EPHA31.85902661
17MAP3K61.82541495
18TYK21.76960156
19IRAK11.76667441
20MAP3K141.72096486
21JAK31.68228178
22ZAP701.68128943
23MAP3K11.63379953
24FER1.63100621
25STK241.59774914
26MAP2K31.59026890
27FGR1.54966804
28SIK31.52956614
29PRPF4B1.52194480
30SIK11.51904676
31TXK1.44438214
32KSR21.36389129
33FGFR41.31112334
34IKBKE1.31061345
35MAP3K111.30730887
36MAP3K91.26420708
37TBK11.25324863
38IRAK21.22686017
39HCK1.20183595
40PTK61.18169221
41TGFBR11.14254134
42IKBKB1.13361361
43FES1.08296915
44JAK21.05160179
45FGFR31.03800361
46MATK1.00363176
47MAP3K130.99509145
48JAK10.98654704
49EPHB20.96555813
50TRIB30.93867372
51CDC42BPA0.92656984
52MET0.91513899
53PRKD20.89672925
54MARK20.89452076
55SMG10.83474474
56TAOK20.82025806
57YES10.80065540
58MAP3K120.78100304
59PTK20.77138034
60TNK20.77066824
61ARAF0.69999096
62TESK20.69539929
63TAOK30.69135631
64TGFBR20.69073192
65BTK0.68085226
66BMPR20.67207270
67STK380.66757926
68MAP2K60.66593208
69LYN0.65218532
70SYK0.61407164
71LRRK20.59588062
72PRKG20.58412566
73MAPKAPK20.57803588
74STK100.56916541
75MAPK70.56432908
76LMTK20.55136405
77RET0.55056097
78PAK40.54276263
79PDPK10.51343572
80WNK10.50084213
81SGK2230.49318340
82SGK4940.49318340
83FYN0.49118452
84KIT0.46636533
85BMX0.44446346
86LCK0.43905001
87PDGFRB0.38940141
88ITK0.38398411
89MAP3K70.36604085
90MAP3K50.36542443
91DMPK0.36034517
92NLK0.35903366
93MARK30.34565646
94KSR10.33816847
95PRKCD0.33580433
96CDK120.33371487
97HIPK20.33227080
98MAPKAPK30.32548689
99RPS6KA10.30342307
100PDGFRA0.30081131

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.71775233
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.08611117
3Linoleic acid metabolism_Homo sapiens_hsa005912.81653123
4Staphylococcus aureus infection_Homo sapiens_hsa051502.64787935
5Arachidonic acid metabolism_Homo sapiens_hsa005902.42588570
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.20080499
7Ether lipid metabolism_Homo sapiens_hsa005652.17664885
8Leishmaniasis_Homo sapiens_hsa051402.02165972
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.98331054
10Osteoclast differentiation_Homo sapiens_hsa043801.96799464
11VEGF signaling pathway_Homo sapiens_hsa043701.94661525
12Tuberculosis_Homo sapiens_hsa051521.71322712
13Acute myeloid leukemia_Homo sapiens_hsa052211.70991127
14Amoebiasis_Homo sapiens_hsa051461.70474044
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57952508
16GnRH signaling pathway_Homo sapiens_hsa049121.55081141
17Toxoplasmosis_Homo sapiens_hsa051451.47092934
18Malaria_Homo sapiens_hsa051441.46966349
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38089826
20Pertussis_Homo sapiens_hsa051331.34276075
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33912281
22Influenza A_Homo sapiens_hsa051641.31602177
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29111383
24TNF signaling pathway_Homo sapiens_hsa046681.28540711
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.23612678
26Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22285202
27Sphingolipid metabolism_Homo sapiens_hsa006001.19417863
28B cell receptor signaling pathway_Homo sapiens_hsa046621.17990855
29Chemokine signaling pathway_Homo sapiens_hsa040621.15083791
30Graft-versus-host disease_Homo sapiens_hsa053321.15005302
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14592694
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.14345358
33Salmonella infection_Homo sapiens_hsa051321.13392903
34Hepatitis C_Homo sapiens_hsa051601.12705736
35Ovarian steroidogenesis_Homo sapiens_hsa049131.10508871
36Choline metabolism in cancer_Homo sapiens_hsa052311.08829168
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.07502632
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06189809
39Shigellosis_Homo sapiens_hsa051311.05790362
40Legionellosis_Homo sapiens_hsa051341.02442966
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02437043
42Platelet activation_Homo sapiens_hsa046111.02169278
43Measles_Homo sapiens_hsa051621.01731124
44Allograft rejection_Homo sapiens_hsa053300.98178542
45Long-term depression_Homo sapiens_hsa047300.95743625
46Pancreatic cancer_Homo sapiens_hsa052120.95721199
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.94604035
48Phagosome_Homo sapiens_hsa041450.94360342
49Renal cell carcinoma_Homo sapiens_hsa052110.94208780
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92719315
51Autoimmune thyroid disease_Homo sapiens_hsa053200.91918265
52Hematopoietic cell lineage_Homo sapiens_hsa046400.88177919
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.83878663
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.83844432
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.82429717
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82245491
57Chronic myeloid leukemia_Homo sapiens_hsa052200.81621327
58Notch signaling pathway_Homo sapiens_hsa043300.81178263
59Endocytosis_Homo sapiens_hsa041440.81095202
60African trypanosomiasis_Homo sapiens_hsa051430.79342713
61Dorso-ventral axis formation_Homo sapiens_hsa043200.79231960
62T cell receptor signaling pathway_Homo sapiens_hsa046600.78013334
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76490487
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.74288023
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73906530
66Antigen processing and presentation_Homo sapiens_hsa046120.71442050
67HIF-1 signaling pathway_Homo sapiens_hsa040660.70189557
68Herpes simplex infection_Homo sapiens_hsa051680.69562906
69Ras signaling pathway_Homo sapiens_hsa040140.69272523
70Bladder cancer_Homo sapiens_hsa052190.68439511
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68311618
72Viral myocarditis_Homo sapiens_hsa054160.67572301
73Histidine metabolism_Homo sapiens_hsa003400.67486559
74Apoptosis_Homo sapiens_hsa042100.67175043
75Type I diabetes mellitus_Homo sapiens_hsa049400.62705133
76Non-small cell lung cancer_Homo sapiens_hsa052230.61534761
77Hepatitis B_Homo sapiens_hsa051610.60707231
78Rheumatoid arthritis_Homo sapiens_hsa053230.59708417
79ErbB signaling pathway_Homo sapiens_hsa040120.57777640
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57408642
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56229072
82Serotonergic synapse_Homo sapiens_hsa047260.53209731
83Prolactin signaling pathway_Homo sapiens_hsa049170.52853733
84Insulin signaling pathway_Homo sapiens_hsa049100.49866579
85Small cell lung cancer_Homo sapiens_hsa052220.49045697
86Rap1 signaling pathway_Homo sapiens_hsa040150.48575038
87Glioma_Homo sapiens_hsa052140.47447342
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.46734714
89MAPK signaling pathway_Homo sapiens_hsa040100.46041601
90Other glycan degradation_Homo sapiens_hsa005110.44213317
91Thyroid cancer_Homo sapiens_hsa052160.44026162
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.42743907
93Proteoglycans in cancer_Homo sapiens_hsa052050.42650416
94Pancreatic secretion_Homo sapiens_hsa049720.42193340
95Adherens junction_Homo sapiens_hsa045200.39696626
96Lysosome_Homo sapiens_hsa041420.39602614
97Asthma_Homo sapiens_hsa053100.38919407
98Estrogen signaling pathway_Homo sapiens_hsa049150.38887618
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38186929
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.37679105

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