PI4K2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycosphingolipid catabolic process (GO:0046479)5.20742647
2oligosaccharide catabolic process (GO:0009313)4.86915802
3glycolipid catabolic process (GO:0019377)4.64206052
4barbed-end actin filament capping (GO:0051016)4.21635277
5peptidyl-glutamic acid carboxylation (GO:0017187)4.16550539
6protein carboxylation (GO:0018214)4.16550539
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.14606611
8cellular response to thyroid hormone stimulus (GO:0097067)4.13688526
9regulation of early endosome to late endosome transport (GO:2000641)4.12530345
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.06093702
11L-phenylalanine catabolic process (GO:0006559)4.06093702
12ceramide catabolic process (GO:0046514)4.05879082
13urea cycle (GO:0000050)4.00394796
14urea metabolic process (GO:0019627)4.00394796
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.94797487
16L-phenylalanine metabolic process (GO:0006558)3.94797487
17positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.84497672
18response to peptidoglycan (GO:0032494)3.80905553
19alpha-linolenic acid metabolic process (GO:0036109)3.79673862
20amino sugar catabolic process (GO:0046348)3.76826630
21plasma lipoprotein particle clearance (GO:0034381)3.72189274
22regulation of mononuclear cell migration (GO:0071675)3.68998457
23negative regulation of interleukin-12 production (GO:0032695)3.67646306
24pinocytosis (GO:0006907)3.66727296
25negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.66076071
26aromatic amino acid family catabolic process (GO:0009074)3.66006293
27negative regulation of fibrinolysis (GO:0051918)3.65984851
28dicarboxylic acid biosynthetic process (GO:0043650)3.64626851
29regulation of vitamin D biosynthetic process (GO:0060556)3.63567165
30nitrogen cycle metabolic process (GO:0071941)3.61965590
31low-density lipoprotein particle clearance (GO:0034383)3.54999806
32regulation of cholesterol homeostasis (GO:2000188)3.52883412
33virion attachment to host cell (GO:0019062)3.50989853
34adhesion of symbiont to host cell (GO:0044650)3.50989853
35complement activation, alternative pathway (GO:0006957)3.50117487
36kynurenine metabolic process (GO:0070189)3.47674172
37decidualization (GO:0046697)3.45242670
38membrane lipid catabolic process (GO:0046466)3.44914662
39bile acid biosynthetic process (GO:0006699)3.39279414
40lipopolysaccharide-mediated signaling pathway (GO:0031663)3.36621734
41mannose metabolic process (GO:0006013)3.36522790
42sphingolipid catabolic process (GO:0030149)3.36108650
43adhesion of symbiont to host (GO:0044406)3.35737596
44stress fiber assembly (GO:0043149)3.34369829
45response to thyroid hormone (GO:0097066)3.33750000
46indole-containing compound catabolic process (GO:0042436)3.31230381
47indolalkylamine catabolic process (GO:0046218)3.31230381
48tryptophan catabolic process (GO:0006569)3.31230381
49regulation of cholesterol storage (GO:0010885)3.27185483
50negative regulation of erythrocyte differentiation (GO:0045647)3.25082259
51positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.25079354
52phospholipid efflux (GO:0033700)3.24776374
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.24184722
54cysteine metabolic process (GO:0006534)3.23338557
55positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.23181584
56skin morphogenesis (GO:0043589)3.22331601
57modulation by symbiont of host cellular process (GO:0044068)3.18511046
58high-density lipoprotein particle remodeling (GO:0034375)3.16957278
59cellular response to arsenic-containing substance (GO:0071243)3.16297229
60regulation of protein activation cascade (GO:2000257)3.13580110
61regulation of fibrinolysis (GO:0051917)3.12554517
62negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.06343484
63tryptophan metabolic process (GO:0006568)3.05466749
64protein-lipid complex remodeling (GO:0034368)3.03085978
65macromolecular complex remodeling (GO:0034367)3.03085978
66plasma lipoprotein particle remodeling (GO:0034369)3.03085978
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.02651065
68positive regulation by organism of defense response of other organism involved in symbiotic interact3.02651065
69modulation by symbiont of host immune response (GO:0052553)3.02651065
70positive regulation by symbiont of host defense response (GO:0052509)3.02651065
71modulation by symbiont of host defense response (GO:0052031)3.02651065
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.02651065
73positive regulation of leukocyte degranulation (GO:0043302)3.01061953
74cholesterol efflux (GO:0033344)2.99468118
75reverse cholesterol transport (GO:0043691)2.98740732
76response to laminar fluid shear stress (GO:0034616)2.96182092
77negative regulation of cholesterol transport (GO:0032375)2.95995246
78negative regulation of sterol transport (GO:0032372)2.95995246
79regulation of leukocyte degranulation (GO:0043300)2.95993808
80positive regulation of lipid catabolic process (GO:0050996)2.95645050
81myeloid dendritic cell differentiation (GO:0043011)2.95528894
82regulation of complement activation (GO:0030449)2.94889178
83glutamate metabolic process (GO:0006536)2.94458379
84regulation of cholesterol esterification (GO:0010872)2.93367625
85adenosine receptor signaling pathway (GO:0001973)2.92867848
86regulation of mast cell degranulation (GO:0043304)2.91422519
87hyaluronan catabolic process (GO:0030214)2.90618260
88regulation of triglyceride catabolic process (GO:0010896)2.90502837
89sulfur amino acid catabolic process (GO:0000098)2.90221824
90positive regulation of chemokine biosynthetic process (GO:0045080)2.89864914
91hemidesmosome assembly (GO:0031581)2.88893766
92glyoxylate metabolic process (GO:0046487)2.86909701
93positive regulation of fatty acid biosynthetic process (GO:0045723)2.86252544
94fibrinolysis (GO:0042730)2.86178569
95plasma lipoprotein particle assembly (GO:0034377)2.84177438
96acute-phase response (GO:0006953)2.82704319
97positive regulation of extracellular matrix organization (GO:1903055)2.82066218
98regulation of macrophage chemotaxis (GO:0010758)2.81648176
99protein-lipid complex assembly (GO:0065005)2.81374184
100regulation of vitamin metabolic process (GO:0030656)2.81358037
101macroautophagy (GO:0016236)2.79097756
102NIK/NF-kappaB signaling (GO:0038061)2.78823174
103serine family amino acid catabolic process (GO:0009071)2.76825730
104bile acid metabolic process (GO:0008206)2.76259848
105cell adhesion mediated by integrin (GO:0033627)2.75601000
106homocysteine metabolic process (GO:0050667)2.75484860
107cellular modified amino acid catabolic process (GO:0042219)2.75165606
108triglyceride homeostasis (GO:0070328)2.74710591
109acylglycerol homeostasis (GO:0055090)2.74710591
110macrophage activation involved in immune response (GO:0002281)2.74242105
111neutrophil activation involved in immune response (GO:0002283)2.73403749
112regulation of podosome assembly (GO:0071801)2.70469427
113epithelial cell differentiation involved in prostate gland development (GO:0060742)2.70262612
114low-density lipoprotein particle remodeling (GO:0034374)2.69452631
115aldehyde catabolic process (GO:0046185)2.69114834
116response to muramyl dipeptide (GO:0032495)2.69086332
117positive regulation of hemostasis (GO:1900048)2.69053376
118positive regulation of blood coagulation (GO:0030194)2.69053376
119regulation of membrane protein ectodomain proteolysis (GO:0051043)2.68777087
120positive regulation of cellular amide metabolic process (GO:0034250)2.68278844
121T-helper 1 type immune response (GO:0042088)2.67141855
122N-acetylneuraminate metabolic process (GO:0006054)2.66097553
123arginine metabolic process (GO:0006525)2.64965862
124dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.64628558
125positive regulation of monocyte chemotaxis (GO:0090026)2.64579309
126positive regulation of cholesterol efflux (GO:0010875)2.62873025
127negative regulation of nitric oxide biosynthetic process (GO:0045019)2.61793297
128plasma lipoprotein particle organization (GO:0071827)2.60327030
129protein-lipid complex subunit organization (GO:0071825)2.60238071
130endodermal cell differentiation (GO:0035987)2.59622046
131endocytic recycling (GO:0032456)2.58427117
132monocyte chemotaxis (GO:0002548)2.58216187
133regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.57883541
134amino-acid betaine metabolic process (GO:0006577)2.57489329
135cellular copper ion homeostasis (GO:0006878)2.57061222
136positive regulation of coagulation (GO:0050820)2.57008530
137epithelial cell-cell adhesion (GO:0090136)2.56376354
138positive regulation of p38MAPK cascade (GO:1900745)2.56220775
139regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.54327030
140regulation of mast cell activation involved in immune response (GO:0033006)2.54257309
141phospholipid homeostasis (GO:0055091)2.52856984
142detection of molecule of bacterial origin (GO:0032490)2.52260975
143aromatic amino acid family metabolic process (GO:0009072)2.51824148
144osteoclast differentiation (GO:0030316)2.50919919
145tyrosine metabolic process (GO:0006570)2.50813856
146regulation of monocyte chemotaxis (GO:0090025)2.50729581
147cortical actin cytoskeleton organization (GO:0030866)2.50597335
148cofactor catabolic process (GO:0051187)2.49845484
149alanine transport (GO:0032328)2.48469362
150positive regulation of lipid storage (GO:0010884)2.47164150
151regulation of myeloid leukocyte mediated immunity (GO:0002886)2.46569017
152cell-substrate junction assembly (GO:0007044)2.44678004
153lysine catabolic process (GO:0006554)2.44585165
154lysine metabolic process (GO:0006553)2.44585165
155regulation of T-helper 2 cell differentiation (GO:0045628)2.44294533
156alpha-amino acid catabolic process (GO:1901606)2.43179312
157regulation of clathrin-mediated endocytosis (GO:2000369)2.41137744
158lipoprotein transport (GO:0042953)2.41003634
159glial cell migration (GO:0008347)2.40461326
160apoptotic cell clearance (GO:0043277)2.39986682
161positive regulation of triglyceride metabolic process (GO:0090208)2.39574655
162lipoprotein metabolic process (GO:0042157)2.38772852
163regulation of chemokine biosynthetic process (GO:0045073)2.37503615
164L-alpha-amino acid transmembrane transport (GO:1902475)2.36779523
165coenzyme catabolic process (GO:0009109)2.35999163
166regulation of superoxide anion generation (GO:0032928)2.35142944
167negative regulation of protein localization to plasma membrane (GO:1903077)2.34761348
168activation of MAPKKK activity (GO:0000185)2.34639190
169positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.34630155
170growth hormone receptor signaling pathway (GO:0060396)2.34558978
171very-low-density lipoprotein particle assembly (GO:0034379)2.34410670
172regulation of lipid catabolic process (GO:0050994)2.33957740
173eosinophil chemotaxis (GO:0048245)2.32482012
174regulation of heterotypic cell-cell adhesion (GO:0034114)2.31408083
175positive regulation of interferon-alpha production (GO:0032727)2.31366599
176cytoskeletal anchoring at plasma membrane (GO:0007016)2.31248709
177protein localization to endosome (GO:0036010)2.31246334
178regulation of plasminogen activation (GO:0010755)2.31123910
179COPI coating of Golgi vesicle (GO:0048205)2.30451436
180Golgi transport vesicle coating (GO:0048200)2.30451436
181modulation by virus of host process (GO:0019054)2.30443061
182dendritic cell differentiation (GO:0097028)2.30251107
183myeloid dendritic cell activation (GO:0001773)2.30178904
184endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.28997167
185response to progesterone (GO:0032570)2.26990027
186regulation of cytokine secretion involved in immune response (GO:0002739)2.26770819
187negative regulation of interleukin-17 production (GO:0032700)2.25823739

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.54984174
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.18174258
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.71454006
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.60584383
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.89952694
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.85622691
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68742752
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.64246551
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.51338073
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.44077810
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.38143675
12* VDR_21846776_ChIP-Seq_THP-1_Human2.33240502
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.22168753
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.21573450
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.20948195
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.19152891
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.16567331
18EGR1_23403033_ChIP-Seq_LIVER_Mouse2.09216612
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05786157
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02378592
21* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97748351
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.96150520
23GATA1_22025678_ChIP-Seq_K562_Human1.86945686
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86384114
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80972233
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77030966
27MYC_22102868_ChIP-Seq_BL_Human1.74929745
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.73677455
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71347354
30LXR_22292898_ChIP-Seq_THP-1_Human1.59116436
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.56786739
32* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.53519107
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53082788
34CLOCK_20551151_ChIP-Seq_293T_Human1.48842049
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47472476
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47367728
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45027228
38UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43910721
39TFEB_21752829_ChIP-Seq_HELA_Human1.40585733
40TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39342481
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38807376
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37188089
43* KDM2B_26808549_Chip-Seq_K562_Human1.35465469
44UBF1/2_26484160_Chip-Seq_HMECs_Human1.33018870
45KDM2B_26808549_Chip-Seq_DND41_Human1.32940966
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.31845392
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30020554
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29666963
49ZNF263_19887448_ChIP-Seq_K562_Human1.29603421
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28016855
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27049983
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.26634369
53TP53_22127205_ChIP-Seq_IMR90_Human1.26151066
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.26129157
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25327013
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24615025
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23953144
58RACK7_27058665_Chip-Seq_MCF-7_Human1.22859146
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22780295
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22342631
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21746066
62SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21200068
63SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21200068
64TCF7_22412390_ChIP-Seq_EML_Mouse1.20751430
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.20473342
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20405403
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20326768
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20179690
69STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19415766
70TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.19396304
71NCOR1_26117541_ChIP-Seq_K562_Human1.18929963
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16983968
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.16844369
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15279600
75* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14239328
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10678252
77* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10616769
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10021691
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.09615189
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09357986
81* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08633906
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08421253
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07865402
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06801657
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06424249
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06268959
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06212851
88MAF_26560356_Chip-Seq_TH2_Human1.04599026
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03386085
90TRIM28_21343339_ChIP-Seq_HEK293_Human1.03262281
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.02956072
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02921325
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02185475
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01158209
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00455456
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00398683
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00368516
98SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99937721
99GATA1_19941826_ChIP-Seq_K562_Human0.99821565
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99498144
101KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98175297
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98140386
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98034747
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97918921
105EGR1_19032775_ChIP-ChIP_M12_Human0.97777845
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96200292
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95109409
108VDR_24787735_ChIP-Seq_THP-1_Human0.94430308
109KDM2B_26808549_Chip-Seq_JURKAT_Human0.93712291
110* ATF3_27146783_Chip-Seq_COLON_Human0.93675471
111PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93385031
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92668743
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92248905
114SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90604382
115* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89909975
116* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89909975
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88995194
118ERG_21242973_ChIP-ChIP_JURKAT_Human0.88637611
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88226700
120CREB1_26743006_Chip-Seq_LNCaP_Human0.87708330
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.86591050
122SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83862256
123GATA2_19941826_ChIP-Seq_K562_Human0.83552440
124MAF_26560356_Chip-Seq_TH1_Human0.82999267
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82438924
126SPI1_23127762_ChIP-Seq_K562_Human0.80413762
127* HNF4A_19822575_ChIP-Seq_HepG2_Human0.80155648
128ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78950854
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78562886
130DROSHA_22980978_ChIP-Seq_HELA_Human0.76119395
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75960756
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.75197398
133VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75156414
134PU_27001747_Chip-Seq_BMDM_Mouse0.74864189
135IKZF1_21737484_ChIP-ChIP_HCT116_Human0.74419329
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74149202
137RARB_27405468_Chip-Seq_BRAIN_Mouse0.73431288
138SOX2_20726797_ChIP-Seq_SW620_Human0.71549004
139* VDR_24763502_ChIP-Seq_THP-1_Human0.70878814
140GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.70797977

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.69611666
2MP0005360_urolithiasis4.37964707
3MP0009840_abnormal_foam_cell3.49300037
4MP0005085_abnormal_gallbladder_physiolo3.39583887
5MP0003303_peritoneal_inflammation3.33688943
6MP0005365_abnormal_bile_salt3.11481495
7MP0003252_abnormal_bile_duct2.75925188
8MP0003191_abnormal_cellular_cholesterol2.68655952
9MP0005058_abnormal_lysosome_morphology2.68071794
10MP0005083_abnormal_biliary_tract2.63991579
11MP0008875_abnormal_xenobiotic_pharmacok2.51122495
12MP0002138_abnormal_hepatobiliary_system2.46423605
13MP0003436_decreased_susceptibility_to2.45814044
14MP0010329_abnormal_lipoprotein_level2.42864971
15MP0000604_amyloidosis2.32396784
16MP0003705_abnormal_hypodermis_morpholog2.31150328
17MP0004510_myositis2.29093289
18MP0008438_abnormal_cutaneous_collagen2.16538250
19MP0004858_abnormal_nervous_system2.13337662
20MP0003172_abnormal_lysosome_physiology1.99314676
21MP0008260_abnormal_autophagy1.97572194
22MP0003075_altered_response_to1.94689240
23MP0003300_gastrointestinal_ulcer1.86133043
24MP0006082_CNS_inflammation1.85581187
25MP0009278_abnormal_bone_marrow1.81695690
26MP0003195_calcinosis1.72498117
27MP0002254_reproductive_system_inflammat1.70965833
28MP0003690_abnormal_glial_cell1.70652971
29MP0000609_abnormal_liver_physiology1.70329393
30MP0000858_altered_metastatic_potential1.67093566
31MP0005167_abnormal_blood-brain_barrier1.66383178
32MP0005332_abnormal_amino_acid1.66040106
33MP0010234_abnormal_vibrissa_follicle1.59997715
34MP0002118_abnormal_lipid_homeostasis1.57695891
35MP0001835_abnormal_antigen_presentation1.55622607
36MP0004947_skin_inflammation1.54117912
37MP0004019_abnormal_vitamin_homeostasis1.53301280
38MP0003279_aneurysm1.51446786
39MP0002419_abnormal_innate_immunity1.47087300
40MP0003329_amyloid_beta_deposits1.47056444
41MP0005464_abnormal_platelet_physiology1.42959962
42MP0005166_decreased_susceptibility_to1.39335740
43MP0005397_hematopoietic_system_phenotyp1.39046637
44MP0001545_abnormal_hematopoietic_system1.39046637
45MP0004859_abnormal_synaptic_plasticity1.36824966
46MP0008961_abnormal_basal_metabolism1.33318793
47MP0005584_abnormal_enzyme/coenzyme_acti1.33259996
48MP0005000_abnormal_immune_tolerance1.32797529
49MP0009764_decreased_sensitivity_to1.32472642
50* MP0005319_abnormal_enzyme/_coenzyme1.28110963
51MP0004185_abnormal_adipocyte_glucose1.27757057
52MP0009785_altered_susceptibility_to1.27192938
53MP0001790_abnormal_immune_system1.26611031
54MP0005387_immune_system_phenotype1.26611031
55MP0002148_abnormal_hypersensitivity_rea1.24602268
56MP0000569_abnormal_digit_pigmentation1.23421424
57MP0001666_abnormal_nutrient_absorption1.22954788
58* MP0008469_abnormal_protein_level1.22399249
59MP0005025_abnormal_response_to1.21619407
60MP0003828_pulmonary_edema1.21313681
61MP0001542_abnormal_bone_strength1.19336875
62MP0008004_abnormal_stomach_pH1.15855522
63MP0003566_abnormal_cell_adhesion1.15352387
64MP0000685_abnormal_immune_system1.14553754
65MP0001533_abnormal_skeleton_physiology1.14130155
66MP0010352_gastrointestinal_tract_polyps1.12664757
67MP0003453_abnormal_keratinocyte_physiol1.11101640
68MP0002796_impaired_skin_barrier1.10327384
69MP0000920_abnormal_myelination1.08742346
70MP0005409_darkened_coat_color1.07527082
71MP0001958_emphysema1.07157162
72MP0005671_abnormal_response_to1.06951084
73MP0003950_abnormal_plasma_membrane1.06729321
74MP0009333_abnormal_splenocyte_physiolog1.06533719
75MP0001216_abnormal_epidermal_layer1.06225133
76MP0004130_abnormal_muscle_cell1.04850822
77MP0006054_spinal_hemorrhage1.04402229
78MP0005076_abnormal_cell_differentiation1.04322925
79MP0002405_respiratory_system_inflammati1.03578098
80MP0005257_abnormal_intraocular_pressure1.01947468
81MP0001845_abnormal_inflammatory_respons1.01672015
82MP0003656_abnormal_erythrocyte_physiolo1.00936091
83MP0003724_increased_susceptibility_to0.99971730
84MP0002060_abnormal_skin_morphology0.99363840
85MP0002896_abnormal_bone_mineralization0.99305929
86MP0004233_abnormal_muscle_weight0.97671971
87MP0005310_abnormal_salivary_gland0.97211998
88MP0005165_increased_susceptibility_to0.96769655
89MP0009643_abnormal_urine_homeostasis0.96356762
90MP0005535_abnormal_body_temperature0.95844388
91MP0005275_abnormal_skin_tensile0.94855506
92MP0000767_abnormal_smooth_muscle0.94003450
93MP0005164_abnormal_response_to0.93260010
94MP0009763_increased_sensitivity_to0.92854992
95MP0002723_abnormal_immune_serum0.92571861
96MP0000598_abnormal_liver_morphology0.92349099
97MP0002998_abnormal_bone_remodeling0.91896775
98MP0003183_abnormal_peptide_metabolism0.91610868
99MP0005390_skeleton_phenotype0.91002143
100MP0003806_abnormal_nucleotide_metabolis0.90403898
101MP0001819_abnormal_immune_cell0.89794602
102MP0002090_abnormal_vision0.89165840
103MP0002420_abnormal_adaptive_immunity0.88949462
104MP0002452_abnormal_antigen_presenting0.87774791
105* MP0003634_abnormal_glial_cell0.87214085
106MP0000015_abnormal_ear_pigmentation0.86845710
107MP0003045_fibrosis0.85477239
108MP0010155_abnormal_intestine_physiology0.83731084
109MP0001800_abnormal_humoral_immune0.82855036
110MP0003795_abnormal_bone_structure0.82068452
111MP0002909_abnormal_adrenal_gland0.81966942
112MP0008874_decreased_physiological_sensi0.81703897
113MP0003448_altered_tumor_morphology0.80110561
114MP0005501_abnormal_skin_physiology0.80050520
115MP0000747_muscle_weakness0.79845895
116MP0005451_abnormal_body_composition0.79596122
117MP0004272_abnormal_basement_membrane0.76692038
118MP0001501_abnormal_sleep_pattern0.75103392
119MP0002136_abnormal_kidney_physiology0.74382442
120MP0001348_abnormal_lacrimal_gland0.74279487
121MP0002332_abnormal_exercise_endurance0.74206288
122MP0003091_abnormal_cell_migration0.74007069
123MP0005595_abnormal_vascular_smooth0.73228916
124MP0001853_heart_inflammation0.72910214
125MP0001881_abnormal_mammary_gland0.72902243
126MP0003941_abnormal_skin_development0.72701032
127MP0001243_abnormal_dermal_layer0.72267681
128MP0000371_diluted_coat_color0.71861152
129MP0002928_abnormal_bile_duct0.70304597
130MP0004782_abnormal_surfactant_physiolog0.69967057
131MP0002078_abnormal_glucose_homeostasis0.68796421
132MP0003633_abnormal_nervous_system0.68512746
133* MP0009642_abnormal_blood_homeostasis0.68479609
134MP0005334_abnormal_fat_pad0.67401913
135MP0002971_abnormal_brown_adipose0.67113151
136MP0002877_abnormal_melanocyte_morpholog0.66663983
137MP0001849_ear_inflammation0.64473861
138MP0000343_altered_response_to0.63208842
139MP0005448_abnormal_energy_balance0.63176581
140MP0005023_abnormal_wound_healing0.62710421
141MP0003868_abnormal_feces_composition0.61618017
142MP0005666_abnormal_adipose_tissue0.61576830
143MP0010307_abnormal_tumor_latency0.61340511

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.94396497
2Xanthomatosis (HP:0000991)4.50387046
3Recurrent gram-negative bacterial infections (HP:0005420)4.17408209
4Complement deficiency (HP:0004431)4.07156644
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.01285605
6Systemic lupus erythematosus (HP:0002725)3.99355170
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.87625195
8Myocardial infarction (HP:0001658)3.84930813
9Intrahepatic cholestasis (HP:0001406)3.76015324
10Increased cerebral lipofuscin (HP:0011813)3.64252841
11Joint hemorrhage (HP:0005261)3.54179840
12Eczematoid dermatitis (HP:0000976)3.51945051
13Abnormality of complement system (HP:0005339)3.44678451
14Vertebral compression fractures (HP:0002953)3.42105536
15Axonal loss (HP:0003447)3.39691396
16Abnormality of glutamine family amino acid metabolism (HP:0010902)3.27368623
17Hyperlipoproteinemia (HP:0010980)3.20814553
18Abnormality of the common coagulation pathway (HP:0010990)3.20385580
19Nuclear cataract (HP:0100018)3.18296589
20Prolonged partial thromboplastin time (HP:0003645)3.04244426
21Increased neuronal autofluorescent lipopigment (HP:0002074)2.84551676
22Epidermoid cyst (HP:0200040)2.82106838
23Hypercholesterolemia (HP:0003124)2.82060704
24Mutism (HP:0002300)2.79460663
25Premature rupture of membranes (HP:0001788)2.73910261
26Glomerulonephritis (HP:0000099)2.72775619
27Recurrent bacterial skin infections (HP:0005406)2.70691028
28Amyloidosis (HP:0011034)2.66785407
29Hypobetalipoproteinemia (HP:0003563)2.64385138
30Neuronal loss in central nervous system (HP:0002529)2.63104398
31Abnormality of the Achilles tendon (HP:0005109)2.63104088
32Autoimmune thrombocytopenia (HP:0001973)2.62358519
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.55240018
34Abnormality of glycolipid metabolism (HP:0010969)2.55240018
35Abnormality of liposaccharide metabolism (HP:0010968)2.55240018
36Thin bony cortex (HP:0002753)2.55235712
37Hypoalphalipoproteinemia (HP:0003233)2.53428419
38Dysostosis multiplex (HP:0000943)2.52961799
39Protrusio acetabuli (HP:0003179)2.51501915
40Diminished motivation (HP:0000745)2.50393355
41Mucopolysacchariduria (HP:0008155)2.48748356
42Urinary glycosaminoglycan excretion (HP:0003541)2.48748356
43Global brain atrophy (HP:0002283)2.44958350
44Skin nodule (HP:0200036)2.43191142
45Recurrent abscess formation (HP:0002722)2.36343521
46Hypolipoproteinemia (HP:0010981)2.34134049
47Tetraparesis (HP:0002273)2.33937380
48Gingival bleeding (HP:0000225)2.33553730
49Sensorimotor neuropathy (HP:0007141)2.32927102
50Esophageal varix (HP:0002040)2.31431854
51Hydroxyprolinuria (HP:0003080)2.31058289
52Abnormality of proline metabolism (HP:0010907)2.31058289
53Cervical subluxation (HP:0003308)2.31011047
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29478047
55Abnormality of polysaccharide metabolism (HP:0011012)2.29478047
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29478047
57Abnormality of sulfur amino acid metabolism (HP:0004339)2.28926616
58Nephritis (HP:0000123)2.27804896
59Osteolytic defects of the hand bones (HP:0009699)2.26356129
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.26356129
61Achilles tendon contracture (HP:0001771)2.25993968
62Supranuclear gaze palsy (HP:0000605)2.25680286
63Asymmetric septal hypertrophy (HP:0001670)2.23515462
64Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.22009861
65Menorrhagia (HP:0000132)2.21364967
66Hyperammonemia (HP:0001987)2.21197872
67Abnormality of macrophages (HP:0004311)2.19837165
68Mitral stenosis (HP:0001718)2.19404225
69Thick nail (HP:0001805)2.18656145
70Bone pain (HP:0002653)2.18549930
71Hyperacusis (HP:0010780)2.18489093
72Vacuolated lymphocytes (HP:0001922)2.17696668
73Loss of speech (HP:0002371)2.14247032
74Spondylolisthesis (HP:0003302)2.13521411
75Increased CSF protein (HP:0002922)2.13465141
76Interstitial pulmonary disease (HP:0006530)2.13435992
77Disinhibition (HP:0000734)2.12929471
78Status epilepticus (HP:0002133)2.12604325
79Ketosis (HP:0001946)2.12544910
80Atrophic scars (HP:0001075)2.11314664
81Hemorrhage of the eye (HP:0011885)2.11177967
82Hyperglycinemia (HP:0002154)2.09537507
83Turricephaly (HP:0000262)2.09487549
84Cerebral aneurysm (HP:0004944)2.05912830
85Neonatal onset (HP:0003623)2.04837301
86Increased serum ferritin (HP:0003281)2.04422578
87Upper motor neuron abnormality (HP:0002127)2.04117338
88Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02655251
89Cerebral inclusion bodies (HP:0100314)2.00810408
90Fat malabsorption (HP:0002630)1.98220954
91Natal tooth (HP:0000695)1.98020017
92Hyperglycinuria (HP:0003108)1.97580335
93Dementia (HP:0000726)1.95994546
94Spontaneous abortion (HP:0005268)1.95829879
95Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95209667
96Abnormality of pyrimidine metabolism (HP:0004353)1.92133227
97Peritonitis (HP:0002586)1.91580399
98Abnormality of nucleobase metabolism (HP:0010932)1.90786352
99Hepatocellular carcinoma (HP:0001402)1.90728727
100Neurofibrillary tangles (HP:0002185)1.90580772
101Thoracic kyphosis (HP:0002942)1.90534408
102Distal lower limb amyotrophy (HP:0008944)1.90286913
103Abnormality of purine metabolism (HP:0004352)1.90112915
104Insomnia (HP:0100785)1.90009481
105Distal lower limb muscle weakness (HP:0009053)1.89902961
106Purpura (HP:0000979)1.89710364
107Joint stiffness (HP:0001387)1.89541501
108Metaphyseal irregularity (HP:0003025)1.89240213
109Peripheral demyelination (HP:0011096)1.89161408
110Stroke (HP:0001297)1.88786576
111Personality changes (HP:0000751)1.87854979
112Gingivitis (HP:0000230)1.87831200
113Progressive neurologic deterioration (HP:0002344)1.87622195
114Abnormality of nail color (HP:0100643)1.86277041
115Upper limb amyotrophy (HP:0009129)1.86180235
116Distal upper limb amyotrophy (HP:0007149)1.86180235
117Cholelithiasis (HP:0001081)1.84655389
118Apathy (HP:0000741)1.84326449
119Cardiomegaly (HP:0001640)1.84035694
120Pathologic fracture (HP:0002756)1.83350722
121Ankle contracture (HP:0006466)1.82976490
122Spastic diplegia (HP:0001264)1.81638410
123Hand muscle atrophy (HP:0009130)1.80873233
124Abnormality of glycine metabolism (HP:0010895)1.80579183
125Abnormality of serine family amino acid metabolism (HP:0010894)1.80579183
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79882660
127Gout (HP:0001997)1.79344822
128Hyperparathyroidism (HP:0000843)1.78931565
129Mediastinal lymphadenopathy (HP:0100721)1.78874647
130Hepatosplenomegaly (HP:0001433)1.76256769
131Protuberant abdomen (HP:0001538)1.75717000
132Abnormality of the intrinsic pathway (HP:0010989)1.75458090
133Back pain (HP:0003418)1.75063492
134Reticulocytosis (HP:0001923)1.75035018
135Abnormal gallbladder morphology (HP:0012437)1.74993607
136Cerebral hemorrhage (HP:0001342)1.74738537
137Malnutrition (HP:0004395)1.71574276
138Segmental peripheral demyelination/remyelination (HP:0003481)1.70210146
139Prolonged neonatal jaundice (HP:0006579)1.69772732
140Abnormality of the thoracic spine (HP:0100711)1.69674502
141Increased connective tissue (HP:0009025)1.68303102
142Short nail (HP:0001799)1.67503587
143Agnosia (HP:0010524)1.64131530
144Ulnar bowing (HP:0003031)1.63710765
145Fragile skin (HP:0001030)1.63515124
146Multiple lipomas (HP:0001012)1.63064631
147Genu recurvatum (HP:0002816)1.62355814
148Ovoid vertebral bodies (HP:0003300)1.60047462
149Abnormality of the distal phalanges of the toes (HP:0010182)1.55913317
150Vascular tortuosity (HP:0004948)1.51694098
151Hematochezia (HP:0002573)1.50454970
152Polycythemia (HP:0001901)1.49523740

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.31194210
2NME23.26414962
3ERN13.21743552
4TRIB33.19738668
5FGFR42.53501936
6TAOK22.42754257
7RIPK42.35041335
8MAP3K92.24606356
9DDR22.21759659
10TBK12.21135941
11KSR22.19645450
12TYK22.15488349
13BMX2.06572904
14TGFBR22.03863744
15PKN22.02617072
16MAP3K141.96350376
17ICK1.95218710
18RIPK11.90319233
19MAP2K31.87500334
20IRAK31.81315002
21JAK11.80850737
22MAP3K21.74429830
23CDC42BPA1.69422151
24TAOK31.67247808
25DAPK21.63074997
26PTK61.58584530
27PAK41.54172736
28EPHB11.52315200
29NTRK11.50662519
30RET1.46818320
31JAK21.43580231
32SMG11.41497805
33PRKD31.38724391
34MAP2K41.38650475
35CAMKK11.36942980
36FGFR31.35812923
37GRK71.35312722
38LIMK11.26478731
39MAP3K11.26455966
40MST1R1.24983082
41TESK11.24549450
42TESK21.21408102
43ABL21.21351900
44ARAF1.20986144
45SIK11.18719657
46SCYL21.16229706
47PTK21.10828423
48MAP3K101.09978210
49TAOK11.09379103
50ALK1.04386558
51STK381.01831186
52MINK10.99582665
53FES0.99163308
54MAP3K110.98090044
55MAP3K130.96646839
56JAK30.96156449
57CAMK1D0.94557154
58PRKCH0.94303048
59EEF2K0.93713921
60HCK0.93584493
61EPHA30.90972398
62EPHB20.90144664
63IRAK20.89380778
64PDK20.89090307
65MAP4K10.88042182
66PRKD20.87870108
67LATS20.87859287
68CLK10.87544725
69EPHA20.85213137
70IKBKE0.85040052
71CSK0.84738368
72BLK0.84011169
73PAK60.83165737
74FER0.82984479
75SGK30.82827164
76PDPK10.82201234
77SIK20.80594654
78CAMK1G0.79961375
79PDGFRA0.79812568
80RPS6KC10.78000115
81RPS6KL10.78000115
82TYRO30.77863151
83MAPKAPK30.75510132
84LRRK20.74961320
85NEK90.73546825
86PDK10.72155599
87ERBB40.71098502
88MAP3K80.70975521
89CAMKK20.69716001
90IKBKB0.69309111
91PAK20.68778273
92MTOR0.67955673
93PBK0.66889916
94CDK60.66010841
95ZAP700.65532285
96RPS6KA20.65076995
97PIM20.62257978
98MAP2K10.61418792
99EGFR0.60966546
100MARK30.60882407
101NTRK30.60853114
102BRAF0.60421379
103KIT0.60174505
104MAP3K50.58892528
105MARK20.57799283
106SYK0.57187461
107DMPK0.55250917
108RPS6KA60.53832266
109KSR10.53772152
110PRKCZ0.53611078
111GRK50.52167126
112DAPK30.51906016
113CDK120.51815455
114BCKDK0.51716223
115CHUK0.51482457
116MAP3K60.50595772
117PTK2B0.50398142
118MAP3K30.49940301
119MATK0.48912474
120FGR0.47366833
121MAPK120.47129040
122MELK0.46791146
123IRAK40.46556148
124PDGFRB0.46252685
125SIK30.46012531
126TTN0.45930222
127CSF1R0.45862000
128ABL10.45587548
129MAPK70.44806863
130STK110.43657793
131MOS0.43323686
132PRKG20.41937871
133EPHA40.41561343
134MAP3K40.40662361
135MAP3K70.40542828
136STK100.39851392
137GSK3A0.39197653
138CDK150.34641813
139MAPKAPK20.33088303
140CDK11A0.32289000
141PAK10.32281138

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.15914851
2Other glycan degradation_Homo sapiens_hsa005114.15666741
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.75789520
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.33304855
5Arginine biosynthesis_Homo sapiens_hsa002203.15532056
6Staphylococcus aureus infection_Homo sapiens_hsa051502.55845111
7Complement and coagulation cascades_Homo sapiens_hsa046102.38919716
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.25972109
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.21567263
10Malaria_Homo sapiens_hsa051441.70543037
11Tryptophan metabolism_Homo sapiens_hsa003801.59931848
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49579854
13Bile secretion_Homo sapiens_hsa049761.48275500
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44087679
15PPAR signaling pathway_Homo sapiens_hsa033201.43438812
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40588868
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39045749
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38118228
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35963022
20Lysosome_Homo sapiens_hsa041421.30743606
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30541301
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26663074
23Fatty acid degradation_Homo sapiens_hsa000711.24265023
24Leishmaniasis_Homo sapiens_hsa051401.19606451
25Vibrio cholerae infection_Homo sapiens_hsa051101.17789252
26Shigellosis_Homo sapiens_hsa051311.16897783
27Prion diseases_Homo sapiens_hsa050201.12704808
28Acute myeloid leukemia_Homo sapiens_hsa052211.12388665
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12308747
30Galactose metabolism_Homo sapiens_hsa000521.11017581
31Sphingolipid metabolism_Homo sapiens_hsa006001.10904405
32Osteoclast differentiation_Homo sapiens_hsa043801.10267504
33Synaptic vesicle cycle_Homo sapiens_hsa047211.06866805
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06251832
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05003971
36Phenylalanine metabolism_Homo sapiens_hsa003601.03991849
37Peroxisome_Homo sapiens_hsa041460.99726250
38Caffeine metabolism_Homo sapiens_hsa002320.99550173
39Histidine metabolism_Homo sapiens_hsa003400.99501088
40Tuberculosis_Homo sapiens_hsa051520.98255687
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96625917
42Renal cell carcinoma_Homo sapiens_hsa052110.94780936
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94705041
44Hepatitis B_Homo sapiens_hsa051610.94435547
45Fructose and mannose metabolism_Homo sapiens_hsa000510.93567691
46Pancreatic cancer_Homo sapiens_hsa052120.92595663
47Proteoglycans in cancer_Homo sapiens_hsa052050.92511106
48Butanoate metabolism_Homo sapiens_hsa006500.91912292
49Allograft rejection_Homo sapiens_hsa053300.91579633
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.88865627
51Pertussis_Homo sapiens_hsa051330.88029644
52Antigen processing and presentation_Homo sapiens_hsa046120.85245918
53Type II diabetes mellitus_Homo sapiens_hsa049300.85083519
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83323002
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.79808621
56Viral myocarditis_Homo sapiens_hsa054160.78645662
57Focal adhesion_Homo sapiens_hsa045100.78539782
58TNF signaling pathway_Homo sapiens_hsa046680.77871257
59Asthma_Homo sapiens_hsa053100.77584699
60Non-small cell lung cancer_Homo sapiens_hsa052230.77526906
61Notch signaling pathway_Homo sapiens_hsa043300.77126782
62Starch and sucrose metabolism_Homo sapiens_hsa005000.76196742
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75569575
64Small cell lung cancer_Homo sapiens_hsa052220.75478489
65Collecting duct acid secretion_Homo sapiens_hsa049660.74957830
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74859885
67Insulin resistance_Homo sapiens_hsa049310.73864557
68ABC transporters_Homo sapiens_hsa020100.71961590
69beta-Alanine metabolism_Homo sapiens_hsa004100.71756051
70Hematopoietic cell lineage_Homo sapiens_hsa046400.71366172
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.71042768
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69848026
73Selenocompound metabolism_Homo sapiens_hsa004500.69137566
74Chemical carcinogenesis_Homo sapiens_hsa052040.69061737
75Rheumatoid arthritis_Homo sapiens_hsa053230.68977039
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.68118499
77Fatty acid metabolism_Homo sapiens_hsa012120.67221277
78Amoebiasis_Homo sapiens_hsa051460.66609441
79Pentose phosphate pathway_Homo sapiens_hsa000300.66355606
80Dorso-ventral axis formation_Homo sapiens_hsa043200.64453786
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64215009
82Autoimmune thyroid disease_Homo sapiens_hsa053200.64042832
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63622377
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62598588
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62481176
86Measles_Homo sapiens_hsa051620.61768743
87Tyrosine metabolism_Homo sapiens_hsa003500.61701041
88Retinol metabolism_Homo sapiens_hsa008300.60592159
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60437469
90HIF-1 signaling pathway_Homo sapiens_hsa040660.60059500
91Prolactin signaling pathway_Homo sapiens_hsa049170.59962894
92ECM-receptor interaction_Homo sapiens_hsa045120.59469883
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.59190211
94Glycerolipid metabolism_Homo sapiens_hsa005610.59059535
95Toxoplasmosis_Homo sapiens_hsa051450.58733605
96Phagosome_Homo sapiens_hsa041450.58420778
97MicroRNAs in cancer_Homo sapiens_hsa052060.58122827
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57933159
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57495652
100Mineral absorption_Homo sapiens_hsa049780.57424672
101Herpes simplex infection_Homo sapiens_hsa051680.56625887
102Glioma_Homo sapiens_hsa052140.56595032
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56089498
104ErbB signaling pathway_Homo sapiens_hsa040120.56083682
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.55983827
106Fat digestion and absorption_Homo sapiens_hsa049750.55700299
107Biosynthesis of amino acids_Homo sapiens_hsa012300.53834166
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.52816056
109HTLV-I infection_Homo sapiens_hsa051660.52769402
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52289828
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.52137032
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51487675
113Influenza A_Homo sapiens_hsa051640.51245266
114Chemokine signaling pathway_Homo sapiens_hsa040620.50908346
115Legionellosis_Homo sapiens_hsa051340.50631732
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.50563370
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.50050040
118Endometrial cancer_Homo sapiens_hsa052130.49537807
119B cell receptor signaling pathway_Homo sapiens_hsa046620.49008067
120Salmonella infection_Homo sapiens_hsa051320.48600946
121African trypanosomiasis_Homo sapiens_hsa051430.48019270
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47590525
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47344638
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.46462371
125Carbon metabolism_Homo sapiens_hsa012000.46384868
126T cell receptor signaling pathway_Homo sapiens_hsa046600.46282479
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45853257
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.45714768
129VEGF signaling pathway_Homo sapiens_hsa043700.45531099
130Hepatitis C_Homo sapiens_hsa051600.45277971
131Epstein-Barr virus infection_Homo sapiens_hsa051690.43320401
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42034848
133Thyroid cancer_Homo sapiens_hsa052160.41663579
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39856495
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38857835
136Lysine degradation_Homo sapiens_hsa003100.38609844
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.38414969
138Insulin signaling pathway_Homo sapiens_hsa049100.38132500
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37911155
140Chronic myeloid leukemia_Homo sapiens_hsa052200.36419489
141Type I diabetes mellitus_Homo sapiens_hsa049400.35735670
142Apoptosis_Homo sapiens_hsa042100.33529404
143Estrogen signaling pathway_Homo sapiens_hsa049150.33260493
144Steroid biosynthesis_Homo sapiens_hsa001000.33039343
145Graft-versus-host disease_Homo sapiens_hsa053320.32422749
146Endocytosis_Homo sapiens_hsa041440.32278937
147mTOR signaling pathway_Homo sapiens_hsa041500.32053094
148GnRH signaling pathway_Homo sapiens_hsa049120.31946118
149Bladder cancer_Homo sapiens_hsa052190.31520732

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