PI4K2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)5.38545338
2intestinal cholesterol absorption (GO:0030299)4.47476347
3cysteine metabolic process (GO:0006534)4.15616220
4chemical homeostasis within a tissue (GO:0048875)4.12331988
5type I interferon signaling pathway (GO:0060337)4.03644810
6cellular response to type I interferon (GO:0071357)4.03644810
7response to type I interferon (GO:0034340)3.96516312
8regulation of vitamin D biosynthetic process (GO:0060556)3.86491070
9regulation of interferon-alpha production (GO:0032647)3.63480695
10regulation of vitamin metabolic process (GO:0030656)3.56713989
11intestinal absorption (GO:0050892)3.48873663
12positive regulation of interferon-alpha production (GO:0032727)3.46585262
13regulation of type I interferon-mediated signaling pathway (GO:0060338)3.43179329
14cellular response to interferon-alpha (GO:0035457)3.38006123
15maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.34612650
16COPI coating of Golgi vesicle (GO:0048205)3.25962909
17Golgi transport vesicle coating (GO:0048200)3.25962909
18homocysteine metabolic process (GO:0050667)3.21838194
19urea metabolic process (GO:0019627)3.21026127
20urea cycle (GO:0000050)3.21026127
21peptide catabolic process (GO:0043171)3.20829638
22NIK/NF-kappaB signaling (GO:0038061)3.20180785
23protein carboxylation (GO:0018214)3.12877099
24peptidyl-glutamic acid carboxylation (GO:0017187)3.12877099
25regulation of T-helper 1 cell differentiation (GO:0045625)3.12087266
26lipopolysaccharide-mediated signaling pathway (GO:0031663)3.10095834
27regulation of RIG-I signaling pathway (GO:0039535)3.08395189
28UDP-N-acetylglucosamine metabolic process (GO:0006047)3.08046447
29sulfur amino acid catabolic process (GO:0000098)3.05381574
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.02268129
31protein retention in ER lumen (GO:0006621)3.02061431
32response to peptidoglycan (GO:0032494)2.99376748
33regulation of cytokine secretion involved in immune response (GO:0002739)2.98765997
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91220831
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.87818031
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.85626084
37L-phenylalanine catabolic process (GO:0006559)2.85626084
38regulation of podosome assembly (GO:0071801)2.84897253
39nitrogen cycle metabolic process (GO:0071941)2.83928708
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.83745934
41L-phenylalanine metabolic process (GO:0006558)2.83745934
42regulation of cholesterol homeostasis (GO:2000188)2.81986809
43hormone catabolic process (GO:0042447)2.80515614
44myeloid dendritic cell differentiation (GO:0043011)2.78593445
45negative regulation of viral genome replication (GO:0045071)2.76618605
46COPII vesicle coating (GO:0048208)2.75840850
47alpha-linolenic acid metabolic process (GO:0036109)2.75752489
48negative regulation of interleukin-12 production (GO:0032695)2.74515251
49pinocytosis (GO:0006907)2.74361233
50response to nitrosative stress (GO:0051409)2.74274233
51high-density lipoprotein particle remodeling (GO:0034375)2.74236284
52negative regulation of fibrinolysis (GO:0051918)2.73890338
53folic acid-containing compound biosynthetic process (GO:0009396)2.73575032
54low-density lipoprotein particle clearance (GO:0034383)2.73264063
55response to interferon-alpha (GO:0035455)2.73017799
56antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72662829
57regulation of interferon-beta biosynthetic process (GO:0045357)2.72507939
58regulation of triglyceride catabolic process (GO:0010896)2.71869876
59positive regulation of gamma-delta T cell activation (GO:0046645)2.71623292
60protein localization to endosome (GO:0036010)2.71326388
61positive regulation of lipoprotein lipase activity (GO:0051006)2.70794305
62positive regulation of triglyceride lipase activity (GO:0061365)2.70794305
63very-low-density lipoprotein particle assembly (GO:0034379)2.70578663
64cellular response to virus (GO:0098586)2.69470800
65positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.69075966
66cholesterol efflux (GO:0033344)2.68716563
67fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.68645241
68interferon-gamma-mediated signaling pathway (GO:0060333)2.67174331
69mitotic chromosome condensation (GO:0007076)2.65282412
70positive regulation of fatty acid biosynthetic process (GO:0045723)2.64284787
71nuclear pore organization (GO:0006999)2.62806933
72plasma lipoprotein particle assembly (GO:0034377)2.62578740
73regulation of response to interferon-gamma (GO:0060330)2.62212640
74T cell migration (GO:0072678)2.60990214
75cholesterol transport (GO:0030301)2.59369457
76sterol transport (GO:0015918)2.59369457
77cellular glucuronidation (GO:0052695)2.58908077
78aromatic amino acid family catabolic process (GO:0009074)2.58000489
79lipoprotein metabolic process (GO:0042157)2.56711991
80negative regulation of sterol transport (GO:0032372)2.56159874
81negative regulation of cholesterol transport (GO:0032375)2.56159874
82plasma lipoprotein particle clearance (GO:0034381)2.56097488
83serine family amino acid metabolic process (GO:0009069)2.55957312
84regulation of protein activation cascade (GO:2000257)2.54443645
85immunoglobulin mediated immune response (GO:0016064)2.54147633
86regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.53793557
87embryonic process involved in female pregnancy (GO:0060136)2.52233739
88reverse cholesterol transport (GO:0043691)2.51661458
89response to xenobiotic stimulus (GO:0009410)2.51069282
90pore complex assembly (GO:0046931)2.50960908
91phospholipid efflux (GO:0033700)2.49149032
92hepatocyte apoptotic process (GO:0097284)2.48875889
93glycine metabolic process (GO:0006544)2.48766268
944-hydroxyproline metabolic process (GO:0019471)2.48452337
95myeloid dendritic cell activation (GO:0001773)2.48039664
96regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.47718158
97germinal center formation (GO:0002467)2.47540066
98bile acid and bile salt transport (GO:0015721)2.47424460
99positive regulation of interferon-beta production (GO:0032728)2.46243703
100serine family amino acid biosynthetic process (GO:0009070)2.46004436
101sterol homeostasis (GO:0055092)2.45275856
102cholesterol homeostasis (GO:0042632)2.44857613
103regulation of complement activation (GO:0030449)2.44819158
104angiotensin maturation (GO:0002003)2.43155236
105negative regulation of myeloid cell apoptotic process (GO:0033033)2.42863729
106tryptophan metabolic process (GO:0006568)2.41131218
107antigen processing and presentation of endogenous antigen (GO:0019883)2.40670453
108protein-lipid complex assembly (GO:0065005)2.40603554
109B cell proliferation (GO:0042100)2.39583010
110amino-acid betaine metabolic process (GO:0006577)2.39087778
111modulation by symbiont of host immune response (GO:0052553)2.38820250
112positive regulation by symbiont of host defense response (GO:0052509)2.38820250
113modulation by symbiont of host defense response (GO:0052031)2.38820250
114modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.38820250
115modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.38820250
116positive regulation by organism of defense response of other organism involved in symbiotic interact2.38820250
117tetrahydrofolate metabolic process (GO:0046653)2.38390678
118positive regulation of Cdc42 GTPase activity (GO:0043089)2.37196420
119fibrinolysis (GO:0042730)2.37064520
120macrophage activation involved in immune response (GO:0002281)2.36991312
121JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.36872637
122mesodermal cell differentiation (GO:0048333)2.36082170
123indolalkylamine catabolic process (GO:0046218)2.35527628
124tryptophan catabolic process (GO:0006569)2.35527628
125indole-containing compound catabolic process (GO:0042436)2.35527628
126CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.34554248
127B cell mediated immunity (GO:0019724)2.33286673
128positive regulation of chemokine biosynthetic process (GO:0045080)2.33193997
129cell adhesion mediated by integrin (GO:0033627)2.33004215
130regulation of fibrinolysis (GO:0051917)2.32474335
131imidazole-containing compound metabolic process (GO:0052803)2.31880103
132xenobiotic catabolic process (GO:0042178)2.31052738
133glucuronate metabolic process (GO:0019585)2.30648393
134uronic acid metabolic process (GO:0006063)2.30648393
135protein-lipid complex remodeling (GO:0034368)2.30448665
136macromolecular complex remodeling (GO:0034367)2.30448665
137plasma lipoprotein particle remodeling (GO:0034369)2.30448665
138regulation of glucose import in response to insulin stimulus (GO:2001273)2.30027197
139positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.29679308
140one-carbon metabolic process (GO:0006730)2.28873186
141bile acid metabolic process (GO:0008206)2.28282725
142positive regulation of type 2 immune response (GO:0002830)2.28063378
143glycosphingolipid catabolic process (GO:0046479)2.27517583
144lysine metabolic process (GO:0006553)2.27510940
145lysine catabolic process (GO:0006554)2.27510940
146regulation of membrane protein ectodomain proteolysis (GO:0051043)2.27306333
147complement activation, alternative pathway (GO:0006957)2.27074750
148negative regulation of fatty acid biosynthetic process (GO:0045717)2.27057476
149regulation of cholesterol esterification (GO:0010872)2.26540055
150serine family amino acid catabolic process (GO:0009071)2.26500363
151T cell lineage commitment (GO:0002360)2.26273311
152nuclear pore complex assembly (GO:0051292)2.25750473
153ethanol oxidation (GO:0006069)2.25455301
154positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.25426764
155regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.25251755
156regulation of chronic inflammatory response (GO:0002676)2.25210828
157phospholipid homeostasis (GO:0055091)2.25026250
158bile acid biosynthetic process (GO:0006699)2.24959499
159acute-phase response (GO:0006953)2.24008538
160positive regulation of humoral immune response (GO:0002922)2.23940864
161acylglycerol homeostasis (GO:0055090)2.23660138
162triglyceride homeostasis (GO:0070328)2.23660138
163regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.22198952
164T-helper 1 type immune response (GO:0042088)2.22021147
165negative regulation of defense response to virus (GO:0050687)2.21885265
166folic acid metabolic process (GO:0046655)2.21332189
167dendritic cell differentiation (GO:0097028)2.21136883
168epithelial cell differentiation involved in prostate gland development (GO:0060742)2.20723286
169regulation of dendritic cell antigen processing and presentation (GO:0002604)2.20274744
170positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.20111081
171L-ascorbic acid metabolic process (GO:0019852)2.19450751
172cellular response to ethanol (GO:0071361)2.19296736
173cellular response to interferon-gamma (GO:0071346)2.17127746
174oligosaccharide catabolic process (GO:0009313)2.16829839
175defense response to virus (GO:0051607)2.16717951
176negative regulation of type I interferon production (GO:0032480)2.15834712
177DNA unwinding involved in DNA replication (GO:0006268)2.14737947
178negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.13499332
179modulation by symbiont of host cellular process (GO:0044068)2.13195313
180positive regulation of endothelial cell apoptotic process (GO:2000353)2.11989953
181detection of other organism (GO:0098543)2.11001482
182negative regulation of cytokine production involved in immune response (GO:0002719)2.10203677
183regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.10179283
184regulation of interleukin-2 biosynthetic process (GO:0045076)2.09998597
185negative regulation of erythrocyte differentiation (GO:0045647)2.09683202
186response to muramyl dipeptide (GO:0032495)2.09277104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.02615239
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.65686334
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.47595429
4GATA1_22025678_ChIP-Seq_K562_Human3.15557317
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.11228498
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.05210405
7E2F7_22180533_ChIP-Seq_HELA_Human2.96855025
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.91994748
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.86537016
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.83273028
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.73317706
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.70182730
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.48424599
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.33726607
15MYC_22102868_ChIP-Seq_BL_Human2.22872073
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.21486947
17CLOCK_20551151_ChIP-Seq_293T_Human2.15585507
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.10334911
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.03433924
20* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.95589056
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93741331
22GATA4_25053715_ChIP-Seq_YYC3_Human1.89888138
23AR_21909140_ChIP-Seq_LNCAP_Human1.89805194
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87583369
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.80901441
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77038574
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70154917
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66649048
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64530885
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62690649
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62419958
32VDR_21846776_ChIP-Seq_THP-1_Human1.61945275
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60041889
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55355501
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55083956
36SALL4_18804426_ChIP-ChIP_XEN_Mouse1.54803915
37GATA6_25053715_ChIP-Seq_YYC3_Human1.52523640
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.51407972
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48878506
40SPI1_23547873_ChIP-Seq_NB4_Human1.48045888
41CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.45286797
42MAF_26560356_Chip-Seq_TH1_Human1.44923390
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44509460
44MYB_26560356_Chip-Seq_TH2_Human1.43792163
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42501321
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.42477012
47FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.42367785
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.41624193
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40711254
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40427441
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.40350528
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36652593
53VDR_24763502_ChIP-Seq_THP-1_Human1.36434708
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35537099
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34466760
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.33355224
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33342342
58SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31702682
59SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31702682
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31584500
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28532163
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25787441
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24893399
64SOX2_20726797_ChIP-Seq_SW620_Human1.24596705
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24405145
66* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23312208
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.21833342
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.21609637
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.21088296
70IRF8_21731497_ChIP-ChIP_J774_Mouse1.20622855
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.20138648
72TCF7_22412390_ChIP-Seq_EML_Mouse1.20121300
73ATF3_27146783_Chip-Seq_COLON_Human1.19543805
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19215435
75ZNF263_19887448_ChIP-Seq_K562_Human1.17773596
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17460050
77* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13379269
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11808886
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10078771
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09933581
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09558736
82PU_27001747_Chip-Seq_BMDM_Mouse1.09349872
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08038191
84IRF8_27001747_Chip-Seq_BMDM_Mouse1.07778376
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05935938
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05783326
87IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03774023
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02915936
89NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00025603
90CDX2_20551321_ChIP-Seq_CACO-2_Human0.98806317
91MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97164001
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96533185
93E2F1_21310950_ChIP-Seq_MCF-7_Human0.96154158
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96002154
95* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94864529
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94224503
97EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94118481
98MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94006144
99* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93000046
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.92900542
101CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92462100
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92337585
103UTX_26944678_Chip-Seq_JUKART_Human0.91690597
104TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91275264
105KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90915356
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90738882
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90585577
108CHD1_26751641_Chip-Seq_LNCaP_Human0.90427128
109MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89816567
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89095222
111PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89024221
112GATA3_24758297_ChIP-Seq_MCF-7_Human0.88600382
113MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88395859
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86343070
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85676398
116GATA2_21666600_ChIP-Seq_HMVEC_Human0.85638972
117NCOR1_26117541_ChIP-Seq_K562_Human0.83269515
118ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83224347
119E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82405576
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82214727
121MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82129576
122MYB_26560356_Chip-Seq_TH1_Human0.81551316
123TFEB_21752829_ChIP-Seq_HELA_Human0.80337887
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79689048
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78886525
126CREB1_15753290_ChIP-ChIP_HEK293T_Human0.78846205
127RACK7_27058665_Chip-Seq_MCF-7_Human0.78443157
128TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77333090
129UBF1/2_26484160_Chip-Seq_HMECs_Human0.76871886
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.76483777
131STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.76114814

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.99434966
2MP0003303_peritoneal_inflammation3.64769768
3MP0004782_abnormal_surfactant_physiolog3.57862896
4MP0005360_urolithiasis3.25209572
5MP0005085_abnormal_gallbladder_physiolo3.24236024
6MP0005083_abnormal_biliary_tract3.10911073
7MP0005365_abnormal_bile_salt3.03406793
8MP0001666_abnormal_nutrient_absorption2.71968279
9MP0009840_abnormal_foam_cell2.40197174
10MP0005451_abnormal_body_composition2.37989329
11MP0008875_abnormal_xenobiotic_pharmacok2.26076362
12MP0003806_abnormal_nucleotide_metabolis2.25915870
13MP0010352_gastrointestinal_tract_polyps2.16666383
14MP0003252_abnormal_bile_duct2.11768289
15MP0010234_abnormal_vibrissa_follicle2.04563874
16MP0003705_abnormal_hypodermis_morpholog2.02507838
17MP0006082_CNS_inflammation1.91888957
18MP0006054_spinal_hemorrhage1.91719963
19MP0005387_immune_system_phenotype1.91217672
20MP0001790_abnormal_immune_system1.91217672
21MP0005000_abnormal_immune_tolerance1.86251426
22MP0003191_abnormal_cellular_cholesterol1.83581559
23MP0000685_abnormal_immune_system1.80279378
24MP0010329_abnormal_lipoprotein_level1.76868804
25MP0002148_abnormal_hypersensitivity_rea1.75300363
26MP0008057_abnormal_DNA_replication1.72765768
27MP0001800_abnormal_humoral_immune1.70559776
28MP0002138_abnormal_hepatobiliary_system1.69715774
29MP0008004_abnormal_stomach_pH1.67995821
30MP0004264_abnormal_extraembryonic_tissu1.65559826
31MP0003763_abnormal_thymus_physiology1.60810939
32MP0001958_emphysema1.58379755
33MP0002877_abnormal_melanocyte_morpholog1.57531439
34MP0002452_abnormal_antigen_presenting1.55067081
35MP0003724_increased_susceptibility_to1.50734069
36MP0002006_tumorigenesis1.50331939
37MP0002419_abnormal_innate_immunity1.49653743
38MP0009333_abnormal_splenocyte_physiolog1.49196996
39MP0002723_abnormal_immune_serum1.47822239
40MP0001853_heart_inflammation1.44046162
41MP0005671_abnormal_response_to1.42003870
42MP0003091_abnormal_cell_migration1.41686779
43MP0003186_abnormal_redox_activity1.35851633
44MP0008438_abnormal_cutaneous_collagen1.33515197
45MP0003693_abnormal_embryo_hatching1.32557097
46MP0005408_hypopigmentation1.30664438
47MP0005220_abnormal_exocrine_pancreas1.30470118
48MP0001819_abnormal_immune_cell1.28023998
49MP0002420_abnormal_adaptive_immunity1.27846233
50MP0000609_abnormal_liver_physiology1.26107822
51MP0004808_abnormal_hematopoietic_stem1.22349099
52MP0003436_decreased_susceptibility_to1.21089506
53MP0002398_abnormal_bone_marrow1.18862602
54MP0004185_abnormal_adipocyte_glucose1.18183966
55MP0003566_abnormal_cell_adhesion1.18070548
56MP0005023_abnormal_wound_healing1.17560012
57MP0003868_abnormal_feces_composition1.11461036
58MP0002118_abnormal_lipid_homeostasis1.10766143
59MP0005310_abnormal_salivary_gland1.10577857
60MP0003111_abnormal_nucleus_morphology1.09886162
61MP0000537_abnormal_urethra_morphology1.09023024
62MP0005275_abnormal_skin_tensile1.08907174
63MP0003950_abnormal_plasma_membrane1.08866452
64MP0000716_abnormal_immune_system1.08005331
65MP0009643_abnormal_urine_homeostasis1.06900084
66MP0010094_abnormal_chromosome_stability1.05188075
67MP0010307_abnormal_tumor_latency1.04516981
68MP0005332_abnormal_amino_acid1.04392780
69MP0002396_abnormal_hematopoietic_system1.03975899
70MP0004947_skin_inflammation1.03857294
71MP0003300_gastrointestinal_ulcer1.03383562
72MP0002009_preneoplasia1.02513377
73MP0004510_myositis1.02064547
74MP0002060_abnormal_skin_morphology1.01820710
75MP0003941_abnormal_skin_development1.00506269
76MP0000490_abnormal_crypts_of1.00491742
77MP0005319_abnormal_enzyme/_coenzyme0.99181605
78MP0005058_abnormal_lysosome_morphology0.98324042
79MP0002429_abnormal_blood_cell0.97203337
80MP0003656_abnormal_erythrocyte_physiolo0.97081964
81MP0002722_abnormal_immune_system0.97033251
82MP0000598_abnormal_liver_morphology0.94356282
83MP0000689_abnormal_spleen_morphology0.94156343
84MP0003221_abnormal_cardiomyocyte_apopto0.94054894
85MP0010155_abnormal_intestine_physiology0.93880946
86MP0005084_abnormal_gallbladder_morpholo0.93334752
87MP0002998_abnormal_bone_remodeling0.91542129
88MP0004019_abnormal_vitamin_homeostasis0.91321409
89MP0002098_abnormal_vibrissa_morphology0.90360361
90MP0008995_early_reproductive_senescence0.89946457
91MP0003453_abnormal_keratinocyte_physiol0.88243739
92MP0010368_abnormal_lymphatic_system0.88087021
93MP0003183_abnormal_peptide_metabolism0.86624043
94MP0003075_altered_response_to0.86403935
95MP0003077_abnormal_cell_cycle0.85989314
96MP0005076_abnormal_cell_differentiation0.85332887
97MP0002295_abnormal_pulmonary_circulatio0.85003688
98MP0009764_decreased_sensitivity_to0.84638450
99MP0003195_calcinosis0.84019753
100MP0005464_abnormal_platelet_physiology0.83471110
101MP0005621_abnormal_cell_physiology0.82780402
102MP0005397_hematopoietic_system_phenotyp0.82462671
103MP0001545_abnormal_hematopoietic_system0.82462671
104MP0002796_impaired_skin_barrier0.81639784
105MP0005166_decreased_susceptibility_to0.81570674
106MP0004957_abnormal_blastocyst_morpholog0.81258353
107MP0001873_stomach_inflammation0.81106624
108MP0005501_abnormal_skin_physiology0.80634455
109MP0001915_intracranial_hemorrhage0.80091673
110MP0009785_altered_susceptibility_to0.80061587
111MP0000566_synostosis0.80033114
112MP0001533_abnormal_skeleton_physiology0.79905491
113MP0009053_abnormal_anal_canal0.78890749
114MP0008469_abnormal_protein_level0.76651426
115MP0000858_altered_metastatic_potential0.74830642
116MP0002132_abnormal_respiratory_system0.74775425
117MP0010678_abnormal_skin_adnexa0.73948421
118MP0001243_abnormal_dermal_layer0.72833872
119MP0003943_abnormal_hepatobiliary_system0.72555410
120MP0009697_abnormal_copulation0.71330233
121MP0000627_abnormal_mammary_gland0.70951560
122MP0001835_abnormal_antigen_presentation0.69446311
123MP0005257_abnormal_intraocular_pressure0.69295543
124MP0001845_abnormal_inflammatory_respons0.69059028
125MP0001216_abnormal_epidermal_layer0.67914144
126MP0002133_abnormal_respiratory_system0.66693807
127MP0005388_respiratory_system_phenotype0.66693807
128MP0001177_atelectasis0.66333608
129MP0001881_abnormal_mammary_gland0.65271460
130MP0002254_reproductive_system_inflammat0.65197415
131MP0002166_altered_tumor_susceptibility0.65172288
132MP0009384_cardiac_valve_regurgitation0.64966967
133MP0002136_abnormal_kidney_physiology0.64468707
134MP0004272_abnormal_basement_membrane0.64351685
135MP0002405_respiratory_system_inflammati0.63988497
136MP0005164_abnormal_response_to0.63795670
137MP0000477_abnormal_intestine_morphology0.63441122
138MP0005636_abnormal_mineral_homeostasis0.62417497
139MP0009763_increased_sensitivity_to0.62416804
140MP0005647_abnormal_sex_gland0.62335335
141MP0002086_abnormal_extraembryonic_tissu0.62250022
142MP0001764_abnormal_homeostasis0.61491409
143MP0005025_abnormal_response_to0.61333264
144MP0003115_abnormal_respiratory_system0.60899643
145MP0003448_altered_tumor_morphology0.60700918
146MP0005248_abnormal_Harderian_gland0.59290746

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)5.98115795
2Abnormality of monocarboxylic acid metabolism (HP:0010996)3.88136482
3Intrahepatic cholestasis (HP:0001406)3.81220878
4Hypobetalipoproteinemia (HP:0003563)3.63798482
5Deep venous thrombosis (HP:0002625)3.41980950
6Xanthomatosis (HP:0000991)3.23682519
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.19815248
8Tubulointerstitial fibrosis (HP:0005576)3.19765827
9Gout (HP:0001997)3.16766939
10Abnormality of the intrinsic pathway (HP:0010989)3.09878552
11Fat malabsorption (HP:0002630)3.07646303
12Hypoglycemic coma (HP:0001325)3.05026643
13Recurrent viral infections (HP:0004429)3.03426040
14Abnormality of glutamine family amino acid metabolism (HP:0010902)3.02896079
15Abnormality of the common coagulation pathway (HP:0010990)2.94622258
16Eczematoid dermatitis (HP:0000976)2.93921060
17Systemic lupus erythematosus (HP:0002725)2.93309095
18Respiratory distress (HP:0002098)2.93305020
19Osteolytic defects of the hand bones (HP:0009699)2.87935119
20Osteolytic defects of the phalanges of the hand (HP:0009771)2.87935119
21IgA deficiency (HP:0002720)2.77085913
22Esophageal varix (HP:0002040)2.71654492
23Autoimmune hemolytic anemia (HP:0001890)2.69971846
24Prolonged partial thromboplastin time (HP:0003645)2.68521221
25Hypolipoproteinemia (HP:0010981)2.68178359
26Recurrent bacterial skin infections (HP:0005406)2.60673125
27Gastrointestinal stroma tumor (HP:0100723)2.60641739
28Abnormality of purine metabolism (HP:0004352)2.59717007
29Abnormality of macrophages (HP:0004311)2.55675008
30Recurrent abscess formation (HP:0002722)2.55511604
31Micronodular cirrhosis (HP:0001413)2.53194814
32Hepatocellular carcinoma (HP:0001402)2.52428744
33Epidermoid cyst (HP:0200040)2.52329493
34Abnormality of liposaccharide metabolism (HP:0010968)2.47958803
35Abnormality of glycosphingolipid metabolism (HP:0004343)2.47958803
36Abnormality of glycolipid metabolism (HP:0010969)2.47958803
37Hydroxyprolinuria (HP:0003080)2.43195915
38Abnormality of proline metabolism (HP:0010907)2.43195915
39Abnormality of nucleobase metabolism (HP:0010932)2.39497770
40Myocardial infarction (HP:0001658)2.39408159
41Steatorrhea (HP:0002570)2.38543764
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.38115473
43Abnormality of sulfur amino acid metabolism (HP:0004339)2.36568444
44Subacute progressive viral hepatitis (HP:0006572)2.35748428
45Polycythemia (HP:0001901)2.34697124
46Vasculitis (HP:0002633)2.34063346
47Ulnar bowing (HP:0003031)2.33891367
48Acanthocytosis (HP:0001927)2.32257707
49Chronic bronchitis (HP:0004469)2.27430706
50Colitis (HP:0002583)2.27119524
51Loss of speech (HP:0002371)2.26038537
52Abnormal cartilage morphology (HP:0002763)2.25919865
53Tachypnea (HP:0002789)2.23439184
54Orchitis (HP:0100796)2.22781785
55Retrobulbar optic neuritis (HP:0100654)2.22426417
56Optic neuritis (HP:0100653)2.22426417
57Chronic diarrhea (HP:0002028)2.19899759
58Joint hemorrhage (HP:0005261)2.17811190
59Hypoglycemic seizures (HP:0002173)2.17129529
60Mediastinal lymphadenopathy (HP:0100721)2.15174470
61Glomerulonephritis (HP:0000099)2.14162545
62Onycholysis (HP:0001806)2.13535283
63Conjugated hyperbilirubinemia (HP:0002908)2.12635815
64Autoimmune thrombocytopenia (HP:0001973)2.11561900
65Increased mean platelet volume (HP:0011877)2.09469148
66Hypoalphalipoproteinemia (HP:0003233)2.09201411
67Cellulitis (HP:0100658)2.08902816
68Hyperglycinuria (HP:0003108)2.08858734
69Ileus (HP:0002595)2.07858901
70Hyperlipoproteinemia (HP:0010980)2.05658460
71Vascular calcification (HP:0004934)2.04326964
72Cupped ribs (HP:0000887)2.03044510
73Tetraparesis (HP:0002273)2.02913607
74Increased IgM level (HP:0003496)2.02910709
75Fatigue (HP:0012378)2.01741340
76Pustule (HP:0200039)2.01546529
77T lymphocytopenia (HP:0005403)2.01050680
78Spastic diplegia (HP:0001264)2.00762685
79Complement deficiency (HP:0004431)1.99924317
80Abnormality of pyrimidine metabolism (HP:0004353)1.99059296
81Abnormal biliary tract morphology (HP:0012440)1.99050086
82Recurrent bronchitis (HP:0002837)1.97524236
83Abnormality of the lumbar spine (HP:0100712)1.97107557
84Abnormality of T cell number (HP:0011839)1.97048733
85Cardiovascular calcification (HP:0011915)1.96907675
86Asymmetry of the thorax (HP:0001555)1.96889778
87Recurrent gram-negative bacterial infections (HP:0005420)1.96700045
88Disinhibition (HP:0000734)1.96342685
89Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92561271
90Hematochezia (HP:0002573)1.92172645
91Gangrene (HP:0100758)1.91872536
92Hyperammonemia (HP:0001987)1.91818227
93Rectal prolapse (HP:0002035)1.91599583
94Meningitis (HP:0001287)1.90871679
95Malnutrition (HP:0004395)1.90702823
96Abdominal distention (HP:0003270)1.90591073
97Abnormality of transition element cation homeostasis (HP:0011030)1.90425951
98Emphysema (HP:0002097)1.90163671
99Tubulointerstitial abnormality (HP:0001969)1.89750303
100Beaking of vertebral bodies (HP:0004568)1.89610975
101Hyperactive renin-angiotensin system (HP:0000841)1.88929500
102Abnormality of complement system (HP:0005339)1.88875280
103Gingivitis (HP:0000230)1.88193796
104Keratoconjunctivitis sicca (HP:0001097)1.87944640
105Increased purine levels (HP:0004368)1.87904190
106Hyperuricemia (HP:0002149)1.87904190
107Lower limb hyperreflexia (HP:0002395)1.87784129
108Abnormal platelet volume (HP:0011876)1.87696671
109Hypercholesterolemia (HP:0003124)1.87505692
110Poikilocytosis (HP:0004447)1.87016641
111Orthostatic hypotension (HP:0001278)1.86776844
112Myositis (HP:0100614)1.85525976
113Thin bony cortex (HP:0002753)1.85407996
114Pulmonary infiltrates (HP:0002113)1.85309077
115Arterial thrombosis (HP:0004420)1.83845659
116Dysostosis multiplex (HP:0000943)1.83388800
117Hyperbilirubinemia (HP:0002904)1.82754810
118Tubulointerstitial nephritis (HP:0001970)1.82307816
119Hyperglycinemia (HP:0002154)1.81447738
120Bone pain (HP:0002653)1.81238201
121Progressive external ophthalmoplegia (HP:0000590)1.80792794
122Right ventricular cardiomyopathy (HP:0011663)1.80602847
123Hemorrhage of the eye (HP:0011885)1.79300465
124Cervical subluxation (HP:0003308)1.78751474
125B lymphocytopenia (HP:0010976)1.78686886
126Abnormality of the vasculature of the conjunctiva (HP:0008054)1.78403130
127Upper motor neuron abnormality (HP:0002127)1.78361675
128Osteomyelitis (HP:0002754)1.77553263
129Abnormality of glycine metabolism (HP:0010895)1.77399535
130Abnormality of serine family amino acid metabolism (HP:0010894)1.77399535
131Vacuolated lymphocytes (HP:0001922)1.76970903
132Increased serum ferritin (HP:0003281)1.76932048
133Hypergammaglobulinemia (HP:0010702)1.76157196
134Abnormality of methionine metabolism (HP:0010901)1.75418310
135Ankyloglossia (HP:0010296)1.73027368
136Glomerulosclerosis (HP:0000096)1.71561389
137Recurrent skin infections (HP:0001581)1.71453562
138Thoracolumbar scoliosis (HP:0002944)1.71268892
139Joint swelling (HP:0001386)1.71082063
140Increased IgE level (HP:0003212)1.70872354
141Tubular atrophy (HP:0000092)1.70578243
142Gingival bleeding (HP:0000225)1.70572117
143Symptomatic seizures (HP:0011145)1.70470459
144Viral hepatitis (HP:0006562)1.69805494
145Spontaneous hematomas (HP:0007420)1.69206372
146Abnormal foot bone ossification (HP:0010675)1.69179438
147Thrombophlebitis (HP:0004418)1.69151034
148Inflammation of the large intestine (HP:0002037)1.69006560
149Nausea (HP:0002018)1.68733730
150Mucosal telangiectasiae (HP:0100579)1.68653244
151Abnormality of the Achilles tendon (HP:0005109)1.67960335
152Abnormality of B cell number (HP:0010975)1.67678487
153Urticaria (HP:0001025)1.67355264
154Gastrointestinal inflammation (HP:0004386)1.67189277
155Abnormality of the distal phalanges of the toes (HP:0010182)1.66997058
156Abnormality of the renal cortex (HP:0011035)1.65689641
157Nephritis (HP:0000123)1.65682086
158IgM deficiency (HP:0002850)1.65350254
159Abnormality of cells of the lymphoid lineage (HP:0012140)1.65070268
160Ridged nail (HP:0001807)1.64935370
161Vertebral compression fractures (HP:0002953)1.64849962
162Lymphoma (HP:0002665)1.64195502
163Flat acetabular roof (HP:0003180)1.64127885
164Gastrointestinal infarctions (HP:0005244)1.64068236
165Biliary tract neoplasm (HP:0100574)1.63346425
166Bowing of the arm (HP:0006488)1.63003696
167Bowed forearm bones (HP:0003956)1.63003696
168Periodontitis (HP:0000704)1.60483962
169Thrombocytosis (HP:0001894)1.59021943
170Abnormality of iron homeostasis (HP:0011031)1.57319653
171Nonimmune hydrops fetalis (HP:0001790)1.57085966
172Hyperglycemia (HP:0003074)1.55582926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.65299348
2FRK3.13494179
3EPHA23.05694053
4ERN12.85214407
5LATS12.64569413
6MST1R2.52387752
7MST42.02785238
8MAP3K32.01563466
9MAP3K131.96539560
10TAOK31.94654438
11SMG11.93971330
12STK31.85151449
13STK241.83737244
14BMPR21.80197972
15RIPK41.76936286
16TRIB31.73555258
17MAP2K21.68630171
18TAOK21.65174520
19RPS6KA41.62210489
20TESK11.62039298
21PTK61.60951451
22MET1.60900277
23FLT31.60328402
24LRRK21.58788264
25IRAK31.57878623
26BCKDK1.57741917
27PKN21.54027235
28STK101.49630129
29ZAP701.48799219
30NEK91.47682130
31CDK61.47639256
32NUAK11.45736532
33MAP4K11.35225535
34PAK41.35156292
35BRSK21.32399644
36PASK1.30793674
37FGFR41.28385075
38STK38L1.26066349
39NME21.25329897
40MAP3K141.23444956
41TBK11.19309141
42SIK11.15117630
43MOS1.14770422
44MAP2K31.14240644
45FGFR21.13570518
46EPHB11.13319894
47JAK31.13230687
48MATK1.09735445
49EIF2AK31.06867004
50RPS6KB21.04671122
51BLK1.04252179
52CHUK1.03367456
53WEE11.02497730
54TYK21.02060647
55TGFBR21.00283561
56RIPK11.00260736
57NEK20.98930002
58CLK10.97484780
59PIK3CG0.96501126
60MAP3K20.95624586
61TGFBR10.95513053
62MAPK110.94869127
63EPHA30.94507154
64PBK0.93541521
65ICK0.92031212
66DDR20.90958455
67MAP3K80.90176700
68MELK0.89963834
69ACVR1B0.89948937
70INSRR0.88509774
71PIM10.88389679
72STK40.87980727
73LATS20.87685841
74TRPM70.83959994
75KSR20.82550679
76PIM20.82104620
77PRKG20.82100110
78DYRK1B0.80223680
79BMX0.78873264
80PTK20.78198591
81EEF2K0.74556086
82PDGFRB0.74133769
83AURKB0.73835131
84BRD40.73314319
85JAK20.72202404
86MAPK150.71540338
87CSF1R0.71247944
88SCYL20.71068517
89ERBB40.70545469
90EIF2AK10.69902334
91CDC42BPA0.69616868
92FGR0.68794478
93GRK70.67563800
94NEK10.65604464
95PDGFRA0.65327706
96MAP3K10.65009935
97PDK20.64374315
98FGFR30.64182378
99EIF2AK20.62808434
100IKBKB0.62507151
101PLK40.61884844
102CDC70.61289590
103GSK3A0.61221953
104MAP3K100.60458236
105TEC0.59672572
106IKBKE0.59400039
107ARAF0.59352230
108ZAK0.58408436
109FER0.58407355
110IRAK20.58334049
111CDK40.57807865
112TTK0.56964056
113CSK0.56948077
114ABL20.56418624
115IRAK10.55402831
116MTOR0.54823592
117CDK120.51541424
118TIE10.50785226
119YES10.50604804
120SRPK10.50432579
121DYRK30.50398856
122TESK20.49967343
123MAP2K10.47671119
124MAPKAPK30.47269572
125ERBB20.47026501
126MAP3K50.46837852
127BTK0.46440983
128SIK30.45761810
129ALK0.45232695
130TTN0.43958755
131IRAK40.43763166
132MAP3K90.43282610
133BRAF0.42160278
134PAK20.41105264
135SYK0.40387043
136CDK70.39972213
137CAMK1D0.38804759
138BUB10.38779624
139JAK10.38038040
140LYN0.38013311
141EGFR0.37913569
142PDPK10.36627362
143TAF10.34361808

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.64520423
2Selenocompound metabolism_Homo sapiens_hsa004502.47140926
3Caffeine metabolism_Homo sapiens_hsa002322.46738099
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.35616919
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18588875
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00709668
7Fat digestion and absorption_Homo sapiens_hsa049752.00524993
8Allograft rejection_Homo sapiens_hsa053301.98111512
9Maturity onset diabetes of the young_Homo sapiens_hsa049501.93852838
10Folate biosynthesis_Homo sapiens_hsa007901.90261837
11Measles_Homo sapiens_hsa051621.88186179
12Tryptophan metabolism_Homo sapiens_hsa003801.87732201
13Histidine metabolism_Homo sapiens_hsa003401.79866700
14Fatty acid degradation_Homo sapiens_hsa000711.77680838
15Sulfur metabolism_Homo sapiens_hsa009201.74679855
16Other glycan degradation_Homo sapiens_hsa005111.74496252
17Asthma_Homo sapiens_hsa053101.72281966
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.69090543
19B cell receptor signaling pathway_Homo sapiens_hsa046621.68665129
20Complement and coagulation cascades_Homo sapiens_hsa046101.67769472
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67396096
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67145187
23Autoimmune thyroid disease_Homo sapiens_hsa053201.65181122
24One carbon pool by folate_Homo sapiens_hsa006701.60795877
25Nitrogen metabolism_Homo sapiens_hsa009101.58536380
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.58453374
27Osteoclast differentiation_Homo sapiens_hsa043801.53610011
28Graft-versus-host disease_Homo sapiens_hsa053321.50803452
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50439454
30Hepatitis B_Homo sapiens_hsa051611.48847243
31Chemical carcinogenesis_Homo sapiens_hsa052041.48667964
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46611985
33Vitamin digestion and absorption_Homo sapiens_hsa049771.43930603
34Arginine biosynthesis_Homo sapiens_hsa002201.36469284
35Peroxisome_Homo sapiens_hsa041461.35763868
36Starch and sucrose metabolism_Homo sapiens_hsa005001.34189441
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32380872
38Glutathione metabolism_Homo sapiens_hsa004801.31389925
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31370918
40PPAR signaling pathway_Homo sapiens_hsa033201.29557548
41Chronic myeloid leukemia_Homo sapiens_hsa052201.27994599
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27481732
43Pancreatic cancer_Homo sapiens_hsa052121.26535470
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24283443
45Mineral absorption_Homo sapiens_hsa049781.24227893
46Renin-angiotensin system_Homo sapiens_hsa046141.23744655
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21479090
48Retinol metabolism_Homo sapiens_hsa008301.20802187
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20475646
50Acute myeloid leukemia_Homo sapiens_hsa052211.19259045
51Tuberculosis_Homo sapiens_hsa051521.17789232
52Viral carcinogenesis_Homo sapiens_hsa052031.16606809
53Legionellosis_Homo sapiens_hsa051341.16040814
54African trypanosomiasis_Homo sapiens_hsa051431.13769855
55Type I diabetes mellitus_Homo sapiens_hsa049401.10419541
56ABC transporters_Homo sapiens_hsa020101.09357272
57Protein export_Homo sapiens_hsa030601.09319473
58Viral myocarditis_Homo sapiens_hsa054161.09227753
59Prion diseases_Homo sapiens_hsa050201.09043513
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.08567026
61Pentose phosphate pathway_Homo sapiens_hsa000301.07590925
62Staphylococcus aureus infection_Homo sapiens_hsa051501.06885888
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06508362
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03432817
65Shigellosis_Homo sapiens_hsa051311.03129122
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.02065743
67beta-Alanine metabolism_Homo sapiens_hsa004100.99244839
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95706570
69Primary immunodeficiency_Homo sapiens_hsa053400.92261890
70Protein digestion and absorption_Homo sapiens_hsa049740.91816329
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.91712138
72Salmonella infection_Homo sapiens_hsa051320.91145785
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89737986
74Epstein-Barr virus infection_Homo sapiens_hsa051690.88945134
75Fatty acid metabolism_Homo sapiens_hsa012120.88697373
76Rheumatoid arthritis_Homo sapiens_hsa053230.87705409
77Galactose metabolism_Homo sapiens_hsa000520.85330407
78Prolactin signaling pathway_Homo sapiens_hsa049170.84104293
79Steroid biosynthesis_Homo sapiens_hsa001000.83860367
80Non-small cell lung cancer_Homo sapiens_hsa052230.83732639
81Propanoate metabolism_Homo sapiens_hsa006400.83545002
82Hematopoietic cell lineage_Homo sapiens_hsa046400.83151043
83Small cell lung cancer_Homo sapiens_hsa052220.80487545
84Phenylalanine metabolism_Homo sapiens_hsa003600.80316519
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79959944
86Bile secretion_Homo sapiens_hsa049760.79291418
87Vitamin B6 metabolism_Homo sapiens_hsa007500.78808934
88T cell receptor signaling pathway_Homo sapiens_hsa046600.77934366
89Sulfur relay system_Homo sapiens_hsa041220.77279498
90Arginine and proline metabolism_Homo sapiens_hsa003300.76587030
91HTLV-I infection_Homo sapiens_hsa051660.74165321
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73418929
93Cell cycle_Homo sapiens_hsa041100.72288928
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72090224
95Biosynthesis of amino acids_Homo sapiens_hsa012300.70957458
96ECM-receptor interaction_Homo sapiens_hsa045120.70186591
97Tyrosine metabolism_Homo sapiens_hsa003500.68378237
98Carbon metabolism_Homo sapiens_hsa012000.67959718
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.67592879
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67252889
101Prostate cancer_Homo sapiens_hsa052150.66783482
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65404721
103Renal cell carcinoma_Homo sapiens_hsa052110.65399678
104p53 signaling pathway_Homo sapiens_hsa041150.65186279
105Bladder cancer_Homo sapiens_hsa052190.64515837
106Malaria_Homo sapiens_hsa051440.63780606
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63580748
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63235152
109Apoptosis_Homo sapiens_hsa042100.60248305
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60169963
111Chemokine signaling pathway_Homo sapiens_hsa040620.59667992
112Fatty acid biosynthesis_Homo sapiens_hsa000610.59380828
113Influenza A_Homo sapiens_hsa051640.59231848
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.59172418
115Sphingolipid metabolism_Homo sapiens_hsa006000.58779935
116Glycerolipid metabolism_Homo sapiens_hsa005610.58646726
117Lysosome_Homo sapiens_hsa041420.58640377
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58490973
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58278364
120Fructose and mannose metabolism_Homo sapiens_hsa000510.57313916
121DNA replication_Homo sapiens_hsa030300.57190022
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56569719
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.56040337
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.55734399
125TNF signaling pathway_Homo sapiens_hsa046680.55689575
126Leishmaniasis_Homo sapiens_hsa051400.54993663
127Adherens junction_Homo sapiens_hsa045200.54518034
128Pertussis_Homo sapiens_hsa051330.52435111
129Antigen processing and presentation_Homo sapiens_hsa046120.52250819
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.51967848
131Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51347463
132Proteoglycans in cancer_Homo sapiens_hsa052050.50897383
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49182860
134Hepatitis C_Homo sapiens_hsa051600.48631050
135MicroRNAs in cancer_Homo sapiens_hsa052060.48137468
136Toxoplasmosis_Homo sapiens_hsa051450.47424389
137Thyroid cancer_Homo sapiens_hsa052160.47288333
138Herpes simplex infection_Homo sapiens_hsa051680.47063670
139Systemic lupus erythematosus_Homo sapiens_hsa053220.46502810
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46259564
141N-Glycan biosynthesis_Homo sapiens_hsa005100.45932656
142Pyruvate metabolism_Homo sapiens_hsa006200.45886050
143Lysine degradation_Homo sapiens_hsa003100.45650345
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44630718
145RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43922031
146Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42104050
147Insulin resistance_Homo sapiens_hsa049310.41719861
148Amoebiasis_Homo sapiens_hsa051460.40089246
149Glycosaminoglycan degradation_Homo sapiens_hsa005310.39525009
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38890706

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