PI4KAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration in hindbrain (GO:0021535)4.42100633
2positive regulation of vascular permeability (GO:0043117)4.19889013
3behavioral response to nicotine (GO:0035095)4.16801607
4tachykinin receptor signaling pathway (GO:0007217)4.13645967
5nephron epithelium morphogenesis (GO:0072088)3.99583132
6nephron tubule morphogenesis (GO:0072078)3.99583132
7hindbrain development (GO:0030902)3.98806924
8drinking behavior (GO:0042756)3.79417252
9genetic imprinting (GO:0071514)3.74595673
10establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.71259352
11mitochondrion transport along microtubule (GO:0047497)3.71259352
12viral transcription (GO:0019083)3.70408380
13translational termination (GO:0006415)3.54745241
14positive regulation of action potential (GO:0045760)3.52314713
15neurotransmitter-gated ion channel clustering (GO:0072578)3.50144534
16pyrimidine nucleobase catabolic process (GO:0006208)3.48553452
17glycerophospholipid catabolic process (GO:0046475)3.48180740
18establishment of mitochondrion localization (GO:0051654)3.45951179
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44026495
20spinal cord development (GO:0021510)3.36230822
21histone H3-K4 trimethylation (GO:0080182)3.28102739
22regulation of timing of cell differentiation (GO:0048505)3.25280675
23negative regulation of astrocyte differentiation (GO:0048712)3.24711086
24head development (GO:0060322)3.16205916
25postsynaptic membrane organization (GO:0001941)3.03223986
26regulation of gene expression by genetic imprinting (GO:0006349)3.02627477
27DNA replication checkpoint (GO:0000076)3.00293864
28short-term memory (GO:0007614)2.98661633
29behavioral response to ethanol (GO:0048149)2.97510944
30cell proliferation in forebrain (GO:0021846)2.94972142
31regulation of development, heterochronic (GO:0040034)2.94435029
32negative regulation of transcription regulatory region DNA binding (GO:2000678)2.91396595
33somite development (GO:0061053)2.89755038
34aggressive behavior (GO:0002118)2.89452442
35DNA topological change (GO:0006265)2.88985926
36response to auditory stimulus (GO:0010996)2.86894862
37erythrocyte maturation (GO:0043249)2.84648413
38axon ensheathment in central nervous system (GO:0032291)2.82821736
39central nervous system myelination (GO:0022010)2.82821736
40histone H3-K9 methylation (GO:0051567)2.82313387
41positive regulation of dendritic spine morphogenesis (GO:0061003)2.81592818
42regulation of histone H3-K4 methylation (GO:0051569)2.81399844
43ribosomal small subunit assembly (GO:0000028)2.81013537
44regulation of nuclear cell cycle DNA replication (GO:0033262)2.79714746
45regulation of action potential (GO:0098900)2.79195155
46kinetochore assembly (GO:0051382)2.78920310
47translational elongation (GO:0006414)2.76161434
48nucleobase catabolic process (GO:0046113)2.76013345
49regulation of microtubule-based movement (GO:0060632)2.75493379
50mechanosensory behavior (GO:0007638)2.73999120
51cellular protein complex disassembly (GO:0043624)2.71839228
52neuronal action potential propagation (GO:0019227)2.69499684
53positive regulation of gastrulation (GO:2000543)2.67522752
54negative regulation of response to food (GO:0032096)2.66578367
55negative regulation of appetite (GO:0032099)2.66578367
56positive regulation by host of viral transcription (GO:0043923)2.65363162
57plasma lipoprotein particle assembly (GO:0034377)2.65140525
58protein complex disassembly (GO:0043241)2.64651639
59positive regulation of CREB transcription factor activity (GO:0032793)2.63737070
60fucose catabolic process (GO:0019317)2.63286875
61L-fucose metabolic process (GO:0042354)2.63286875
62L-fucose catabolic process (GO:0042355)2.63286875
63sulfate transmembrane transport (GO:1902358)2.60232141
64positive regulation of megakaryocyte differentiation (GO:0045654)2.59777076
65cell differentiation in spinal cord (GO:0021515)2.59542507
66spinal cord association neuron differentiation (GO:0021527)2.58256963
67auditory behavior (GO:0031223)2.57757424
68dendritic spine morphogenesis (GO:0060997)2.57167497
69regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.56486647
70urinary tract smooth muscle contraction (GO:0014848)2.55994159
71DNA methylation involved in gamete generation (GO:0043046)2.54918277
72renal tubule morphogenesis (GO:0061333)2.54440425
73nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.53059271
74forebrain neuron differentiation (GO:0021879)2.48967460
75positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.48797896
76terpenoid biosynthetic process (GO:0016114)2.47994249
77protein-cofactor linkage (GO:0018065)2.47258379
78protein localization to synapse (GO:0035418)2.47247802
79neuron fate determination (GO:0048664)2.47038585
80replication fork processing (GO:0031297)2.46898991
81positive regulation of synaptic transmission, GABAergic (GO:0032230)2.46046820
82lung epithelium development (GO:0060428)2.45805715
83DNA strand renaturation (GO:0000733)2.45437162
84positive regulation of dendrite morphogenesis (GO:0050775)2.45076299
85macromolecular complex disassembly (GO:0032984)2.44936013
86DNA methylation (GO:0006306)2.44538046
87DNA alkylation (GO:0006305)2.44538046
88viral life cycle (GO:0019058)2.44348052
89mitochondrial respiratory chain complex I assembly (GO:0032981)2.41124857
90NADH dehydrogenase complex assembly (GO:0010257)2.41124857
91mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.41124857
92very-low-density lipoprotein particle assembly (GO:0034379)2.40417932
93SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.40297747
94regulation of non-canonical Wnt signaling pathway (GO:2000050)2.39618912
95maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.38404846
96regulation of synapse maturation (GO:0090128)2.38287814
97synaptic transmission, cholinergic (GO:0007271)2.37595492
98mRNA splice site selection (GO:0006376)2.36974751
99cotranslational protein targeting to membrane (GO:0006613)2.36653975
100positive regulation of synapse maturation (GO:0090129)2.35762236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.94794242
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.25497444
3ZNF274_21170338_ChIP-Seq_K562_Hela3.06164984
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.82839196
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.76670981
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51556060
7CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.36248910
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.30413202
9REST_21632747_ChIP-Seq_MESCs_Mouse2.20565256
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18800977
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.17074771
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.10360987
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01943404
14VDR_22108803_ChIP-Seq_LS180_Human1.96143854
15JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89879168
16SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85699693
17EZH2_27294783_Chip-Seq_ESCs_Mouse1.78142531
18RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.76394595
19ERG_21242973_ChIP-ChIP_JURKAT_Human1.75800241
20RNF2_27304074_Chip-Seq_NSC_Mouse1.75245116
21REST_18959480_ChIP-ChIP_MESCs_Mouse1.73846233
22DROSHA_22980978_ChIP-Seq_HELA_Human1.66339873
23CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.65304329
24CTCF_27219007_Chip-Seq_Bcells_Human1.63252999
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59785055
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58947386
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54203278
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.47464842
29P68_20966046_ChIP-Seq_HELA_Human1.47146656
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44117318
31ERA_21632823_ChIP-Seq_H3396_Human1.41786668
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40740373
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37451855
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.36587929
35SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33864754
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33723028
37PHF8_20622854_ChIP-Seq_HELA_Human1.32945555
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.31715233
39IRF1_19129219_ChIP-ChIP_H3396_Human1.30470460
40ETV2_25802403_ChIP-Seq_MESCs_Mouse1.30314332
41E2F1_20622854_ChIP-Seq_HELA_Human1.25031879
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23426407
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23426407
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.23043403
45MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.21077783
46E2F1_17053090_ChIP-ChIP_MCF-7_Human1.20977577
47SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17282194
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.17035258
49FOXP1_21924763_ChIP-Seq_HESCs_Human1.16757472
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.16577997
51OCT4_20526341_ChIP-Seq_ESCs_Human1.16020543
52XRN2_22483619_ChIP-Seq_HELA_Human1.16019792
53OCT4_19829295_ChIP-Seq_ESCs_Human1.14638426
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14026192
55SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13545383
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.12119278
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.11753363
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10825657
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10825657
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10416966
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09802201
62CIITA_25753668_ChIP-Seq_RAJI_Human1.09604316
63AR_21572438_ChIP-Seq_LNCaP_Human1.09346069
64KDM2B_26808549_Chip-Seq_K562_Human1.08328752
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07864513
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07259444
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07180110
68RARB_27405468_Chip-Seq_BRAIN_Mouse1.06361600
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05509369
70SA1_27219007_Chip-Seq_Bcells_Human1.04576386
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.04455884
72BCL6_27268052_Chip-Seq_Bcells_Human1.04430834
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04338648
74YY1_22570637_ChIP-Seq_MALME-3M_Human1.04173372
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04160592
76WDR5_24793694_ChIP-Seq_LNCAP_Human1.03752654
77NCOR1_26117541_ChIP-Seq_K562_Human1.03708155
78SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03322291
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01486802
80KDM5A_27292631_Chip-Seq_BREAST_Human1.01174954
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00612936
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99484179
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97699832
84DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96804964
85NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.96664783
86* GATA3_21878914_ChIP-Seq_MCF-7_Human0.96389911
87TP53_22573176_ChIP-Seq_HFKS_Human0.96161660
88EST1_17652178_ChIP-ChIP_JURKAT_Human0.96056495
89MYC_19829295_ChIP-Seq_ESCs_Human0.95446225
90TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94637492
91RAC3_21632823_ChIP-Seq_H3396_Human0.93436784
92NCOR_22424771_ChIP-Seq_293T_Human0.92018544
93SA1_27219007_Chip-Seq_ERYTHROID_Human0.90822649
94* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90619907
95* CTCF_20526341_ChIP-Seq_ESCs_Human0.90530714
96YY1_21170310_ChIP-Seq_MESCs_Mouse0.90083137
97TAF2_19829295_ChIP-Seq_ESCs_Human0.89494152
98SMC4_20622854_ChIP-Seq_HELA_Human0.89464372
99RARA_24833708_ChIP-Seq_LIVER_Mouse0.88738604
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87869713

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.81427092
2MP0003122_maternal_imprinting3.63784918
3MP0003787_abnormal_imprinting2.89192009
4MP0008995_early_reproductive_senescence2.82079715
5MP0001968_abnormal_touch/_nociception2.66268695
6MP0000566_synostosis2.56289582
7MP0003878_abnormal_ear_physiology2.40535416
8MP0005377_hearing/vestibular/ear_phenot2.40535416
9MP0001529_abnormal_vocalization2.36121494
10MP0003121_genomic_imprinting2.33624865
11MP0003123_paternal_imprinting2.27781737
12MP0004885_abnormal_endolymph2.21219347
13MP0002938_white_spotting2.16169235
14MP0002736_abnormal_nociception_after2.03410402
15MP0005646_abnormal_pituitary_gland1.90554802
16MP0000778_abnormal_nervous_system1.74793600
17MP0002735_abnormal_chemical_nociception1.72362523
18MP0008877_abnormal_DNA_methylation1.70351238
19MP0003880_abnormal_central_pattern1.69493761
20MP0006276_abnormal_autonomic_nervous1.68543110
21MP0000631_abnormal_neuroendocrine_gland1.66658564
22MP0009379_abnormal_foot_pigmentation1.63658084
23MP0004742_abnormal_vestibular_system1.63325590
24MP0002557_abnormal_social/conspecific_i1.60043335
25MP0005360_urolithiasis1.54658976
26MP0005551_abnormal_eye_electrophysiolog1.49429984
27MP0005423_abnormal_somatic_nervous1.45791342
28MP0004133_heterotaxia1.45427347
29MP0005499_abnormal_olfactory_system1.45091095
30MP0005394_taste/olfaction_phenotype1.45091095
31MP0003136_yellow_coat_color1.41199520
32MP0004859_abnormal_synaptic_plasticity1.37842448
33MP0002638_abnormal_pupillary_reflex1.34704784
34MP0002653_abnormal_ependyma_morphology1.33639577
35MP0008789_abnormal_olfactory_epithelium1.33126272
36MP0003635_abnormal_synaptic_transmissio1.32640296
37MP0004142_abnormal_muscle_tone1.32262219
38MP0002572_abnormal_emotion/affect_behav1.32088109
39MP0004147_increased_porphyrin_level1.31691303
40MP0008872_abnormal_physiological_respon1.30932978
41MP0002734_abnormal_mechanical_nocicepti1.30337186
42MP0003567_abnormal_fetal_cardiomyocyte1.29083783
43MP0002063_abnormal_learning/memory/cond1.27828526
44MP0008058_abnormal_DNA_repair1.27518016
45MP0002163_abnormal_gland_morphology1.26291519
46MP0002272_abnormal_nervous_system1.24532959
47MP0000955_abnormal_spinal_cord1.23980070
48MP0003698_abnormal_male_reproductive1.21530419
49MP0003938_abnormal_ear_development1.21266761
50MP0009745_abnormal_behavioral_response1.20159667
51MP0002249_abnormal_larynx_morphology1.18335980
52MP0002210_abnormal_sex_determination1.16621313
53MP0001502_abnormal_circadian_rhythm1.13115436
54MP0002822_catalepsy1.12245308
55MP0004924_abnormal_behavior1.12176935
56MP0005386_behavior/neurological_phenoty1.12176935
57MP0003195_calcinosis1.11925005
58MP0002067_abnormal_sensory_capabilities1.11675088
59MP0003942_abnormal_urinary_system1.08731112
60MP0001970_abnormal_pain_threshold1.08378007
61MP0001293_anophthalmia1.07985348
62MP0002184_abnormal_innervation1.07503893
63MP0001486_abnormal_startle_reflex1.04692087
64MP0001929_abnormal_gametogenesis1.04435631
65MP0000026_abnormal_inner_ear1.04281253
66MP0002733_abnormal_thermal_nociception1.04139676
67MP0001485_abnormal_pinna_reflex1.01801213
68MP0005645_abnormal_hypothalamus_physiol1.01778588
69MP0003861_abnormal_nervous_system1.01196866
70MP0003890_abnormal_embryonic-extraembry0.98883734
71MP0002064_seizures0.98665792
72MP0002882_abnormal_neuron_morphology0.97544404
73MP0002752_abnormal_somatic_nervous0.96749380
74MP0002160_abnormal_reproductive_system0.96168581
75MP0000049_abnormal_middle_ear0.94745465
76MP0002152_abnormal_brain_morphology0.93701954
77MP0001145_abnormal_male_reproductive0.93398463
78MP0000639_abnormal_adrenal_gland0.91198402
79MP0000653_abnormal_sex_gland0.90276042
80MP0002102_abnormal_ear_morphology0.89441067
81MP0010329_abnormal_lipoprotein_level0.89076165
82MP0001986_abnormal_taste_sensitivity0.86617903
83MP0005195_abnormal_posterior_eye0.86275808
84MP0002277_abnormal_respiratory_mucosa0.85562556
85MP0004019_abnormal_vitamin_homeostasis0.85229075
86MP0005410_abnormal_fertilization0.84895130
87MP0000678_abnormal_parathyroid_gland0.84055277
88MP0001963_abnormal_hearing_physiology0.81454521
89MP0005379_endocrine/exocrine_gland_phen0.80899861
90MP0001286_abnormal_eye_development0.78393572
91MP0009046_muscle_twitch0.77988712
92MP0003119_abnormal_digestive_system0.77345864
93MP0001440_abnormal_grooming_behavior0.76303332
94MP0008875_abnormal_xenobiotic_pharmacok0.76131390
95MP0002229_neurodegeneration0.75015213
96MP0004043_abnormal_pH_regulation0.73134155
97MP0002161_abnormal_fertility/fecundity0.73080908
98MP0001764_abnormal_homeostasis0.71891195
99MP0005636_abnormal_mineral_homeostasis0.71347677
100MP0003646_muscle_fatigue0.71096220

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the aortic arch (HP:0012303)3.49624815
2Truncus arteriosus (HP:0001660)3.40617713
3Type II lissencephaly (HP:0007260)3.04879587
4Hyperthyroidism (HP:0000836)3.03493651
5Abnormality of cells of the erythroid lineage (HP:0012130)2.97897031
6Nephronophthisis (HP:0000090)2.93984304
7Reticulocytopenia (HP:0001896)2.93445708
8Abnormal number of erythroid precursors (HP:0012131)2.93122126
9Abnormality of cochlea (HP:0000375)2.84904973
10Abnormality of midbrain morphology (HP:0002418)2.84721388
11Molar tooth sign on MRI (HP:0002419)2.84721388
12Retinal dysplasia (HP:0007973)2.83621826
13Diastasis recti (HP:0001540)2.83394686
14Abnormality of DNA repair (HP:0003254)2.73759474
15Morphological abnormality of the inner ear (HP:0011390)2.67931189
16Cerebellar dysplasia (HP:0007033)2.66491584
17Pancreatic fibrosis (HP:0100732)2.58158114
18Abnormality of the labia minora (HP:0012880)2.53558632
19Polydipsia (HP:0001959)2.52529206
20Abnormal drinking behavior (HP:0030082)2.52529206
21Abnormality of the renal medulla (HP:0100957)2.43295883
22Enlarged kidneys (HP:0000105)2.39480071
23Concave nail (HP:0001598)2.38726502
24Facial hemangioma (HP:0000329)2.35030310
25True hermaphroditism (HP:0010459)2.33693087
26Hepatoblastoma (HP:0002884)2.31804383
27Pallor (HP:0000980)2.31777184
28Abnormality of reticulocytes (HP:0004312)2.25492162
29Rib fusion (HP:0000902)2.23423148
30Broad alveolar ridges (HP:0000187)2.20252012
31Lissencephaly (HP:0001339)2.17213770
32Hypoplasia of the pons (HP:0012110)2.14534015
33Pancreatic cysts (HP:0001737)2.13529598
34Abnormality of the pons (HP:0007361)2.11602482
35Patellar aplasia (HP:0006443)2.09283184
36Duplicated collecting system (HP:0000081)2.07958057
37Anophthalmia (HP:0000528)2.06879211
38Abnormality of the renal collecting system (HP:0004742)2.04941224
39Abnormality of the heme biosynthetic pathway (HP:0010472)2.03161169
40Polyuria (HP:0000103)2.01522221
41Abnormality of the renal cortex (HP:0011035)2.00861687
42Abnormal rod and cone electroretinograms (HP:0008323)1.99994664
43Pachygyria (HP:0001302)1.98468033
44Medial flaring of the eyebrow (HP:0010747)1.97264286
45Cystic liver disease (HP:0006706)1.93954471
46Bilateral microphthalmos (HP:0007633)1.93823017
47Reticulocytosis (HP:0001923)1.93303640
48Abnormal urine output (HP:0012590)1.92689833
49Abnormal number of incisors (HP:0011064)1.92543892
50Aplasia/Hypoplasia of the patella (HP:0006498)1.92485671
51Status epilepticus (HP:0002133)1.92420063
52Impulsivity (HP:0100710)1.91313712
53Sclerocornea (HP:0000647)1.90055295
5411 pairs of ribs (HP:0000878)1.88405703
55Epileptic encephalopathy (HP:0200134)1.85397076
56Severe visual impairment (HP:0001141)1.84865946
57Aplasia/Hypoplasia of the sternum (HP:0006714)1.84763528
58Abnormality of dental color (HP:0011073)1.82203930
59Retinal atrophy (HP:0001105)1.81499977
60Oligodactyly (hands) (HP:0001180)1.81484859
61Polyphagia (HP:0002591)1.81472148
62Seborrheic dermatitis (HP:0001051)1.81115387
63Postaxial foot polydactyly (HP:0001830)1.80252214
64Chronic hepatic failure (HP:0100626)1.79895986
65Birth length less than 3rd percentile (HP:0003561)1.79694059
66Gait imbalance (HP:0002141)1.79224811
67Ectopic kidney (HP:0000086)1.79165820
68Abnormality of the 4th metacarpal (HP:0010012)1.79136003
69Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76152977
70Pendular nystagmus (HP:0012043)1.73963675
71Congenital stationary night blindness (HP:0007642)1.73042600
72Septo-optic dysplasia (HP:0100842)1.72727848
73Acute necrotizing encephalopathy (HP:0006965)1.70887391
74Hypoplastic iliac wings (HP:0002866)1.70429160
75Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.69602328
76Chromsome breakage (HP:0040012)1.69097349
77Anencephaly (HP:0002323)1.67429831
78Abnormal hemoglobin (HP:0011902)1.66329512
79Supernumerary bones of the axial skeleton (HP:0009144)1.66188914
80Macrocytic anemia (HP:0001972)1.65886268
81Horseshoe kidney (HP:0000085)1.65492901
82Abolished electroretinogram (ERG) (HP:0000550)1.65044894
83Ulnar claw (HP:0001178)1.64993841
84Midline defect of the nose (HP:0004122)1.64886948
85Deep palmar crease (HP:0006191)1.63890733
86Severe muscular hypotonia (HP:0006829)1.63695808
87Acute encephalopathy (HP:0006846)1.63304311
88Protruding tongue (HP:0010808)1.63278635
89Prominent nasal bridge (HP:0000426)1.63028245
90Optic nerve coloboma (HP:0000588)1.62954318
91Short 4th metacarpal (HP:0010044)1.62185773
92Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.62185773
93Abnormality of renal excretion (HP:0011036)1.61757194
94Growth hormone deficiency (HP:0000824)1.61714089
95Meckel diverticulum (HP:0002245)1.59396390
96Broad palm (HP:0001169)1.59048196
97Occipital encephalocele (HP:0002085)1.58623688
98Holoprosencephaly (HP:0001360)1.58471439
99Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.58405190
100Absent epiphyses (HP:0010577)1.58405190

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.47978457
2NTRK33.62047152
3TYRO33.04810086
4MARK13.04596809
5MAPK132.70122752
6CASK2.67161751
7BMPR1B2.36660712
8FGFR22.28587170
9SIK22.25190801
10TAOK32.19037748
11NTRK22.13668955
12DYRK22.02158645
13MAPK151.99739789
14PNCK1.73870069
15WNK31.66521539
16STK391.59106109
17ZAK1.56994456
18PLK41.53510119
19EPHA41.48080583
20MAP3K71.45214458
21ADRBK21.37791703
22MAP3K41.33162936
23CDK81.23671373
24WEE11.22309352
25BRSK21.21967296
26CAMK1D1.17158105
27FGFR41.16240248
28MAP2K61.14326176
29PKN11.12262473
30FRK1.10866046
31PRKCG1.09522516
32NME11.07050110
33MARK21.06180729
34CAMK1G1.04336118
35TNIK1.04244941
36NEK21.01034832
37TLK10.99934841
38WNK10.97389495
39MAP2K40.92423097
40ICK0.90889448
41MKNK20.90631487
42INSRR0.87154608
43TNK20.85314236
44TGFBR10.84864542
45STK110.83807417
46PRKAA10.81444207
47DAPK20.78781592
48DYRK1A0.76529039
49MAP4K20.76108597
50SGK10.75870949
51CHEK20.75122047
52CAMK10.74643553
53ATR0.73942183
54MARK30.73165113
55FGFR30.72086072
56OXSR10.69441708
57DYRK1B0.69429503
58CDK30.69132368
59NUAK10.68674509
60CDC70.66979095
61BRSK10.66883320
62SGK2230.66756103
63SGK4940.66756103
64TEC0.66425558
65ERBB20.65957689
66CSNK1E0.65586923
67PINK10.65206678
68PRKCZ0.62339981
69UHMK10.56295314
70PHKG20.55639070
71PHKG10.55639070
72MAP2K20.55333533
73ATM0.55156935
74MAP3K20.54944999
75KSR20.54523915
76RIPK40.52867873
77CAMK40.51008382
78MAPK120.49093034
79RPS6KA60.48797206
80CDK10.48112955
81CDK20.47406014
82GSK3B0.46860925
83AKT10.43442816
84PRKDC0.41898622
85GRK10.41638280
86MAPK80.40591020
87PRKCQ0.39630992
88PRKAA20.39573725
89ITK0.39062137
90MINK10.38161962
91RET0.37757184
92PRKACA0.37368681
93CSNK1A10.34484519
94CLK10.33983154
95MAP3K100.33355623
96RPS6KA30.33290227
97MAPK140.32408692
98MAP3K90.31637233
99MAPKAPK50.31472063
100CDK50.31358650

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.27214004
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.95295604
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.66275636
4Steroid biosynthesis_Homo sapiens_hsa001002.63159984
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.44449371
6Nicotine addiction_Homo sapiens_hsa050332.36817521
7Homologous recombination_Homo sapiens_hsa034402.33375683
8Fanconi anemia pathway_Homo sapiens_hsa034602.22391351
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.18082743
10Fat digestion and absorption_Homo sapiens_hsa049752.08108285
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.02744846
12Linoleic acid metabolism_Homo sapiens_hsa005912.01765824
13Butanoate metabolism_Homo sapiens_hsa006501.99751686
14Ether lipid metabolism_Homo sapiens_hsa005651.93746023
15Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.91717811
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87896982
17Olfactory transduction_Homo sapiens_hsa047401.77161903
18Oxidative phosphorylation_Homo sapiens_hsa001901.70969713
19One carbon pool by folate_Homo sapiens_hsa006701.53667109
20Vitamin digestion and absorption_Homo sapiens_hsa049771.53373755
21Nitrogen metabolism_Homo sapiens_hsa009101.48441750
22Basal transcription factors_Homo sapiens_hsa030221.47756841
23Phototransduction_Homo sapiens_hsa047441.41996970
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37147713
25Regulation of autophagy_Homo sapiens_hsa041401.37036175
26Selenocompound metabolism_Homo sapiens_hsa004501.32849758
27Sulfur relay system_Homo sapiens_hsa041221.31215127
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.29515936
29ABC transporters_Homo sapiens_hsa020101.28677856
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28378020
31Insulin secretion_Homo sapiens_hsa049111.26643507
32Type II diabetes mellitus_Homo sapiens_hsa049301.22857292
33Parkinsons disease_Homo sapiens_hsa050121.21684103
34Taste transduction_Homo sapiens_hsa047421.21637180
35Glutamatergic synapse_Homo sapiens_hsa047241.16948988
36Morphine addiction_Homo sapiens_hsa050321.12955544
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11112537
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10765373
39Collecting duct acid secretion_Homo sapiens_hsa049661.09593647
40Basal cell carcinoma_Homo sapiens_hsa052171.09345575
41Fatty acid biosynthesis_Homo sapiens_hsa000611.05384046
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03778801
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03699324
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03184841
45Lysine degradation_Homo sapiens_hsa003101.00490793
46Dorso-ventral axis formation_Homo sapiens_hsa043200.99491482
47Cocaine addiction_Homo sapiens_hsa050300.97955781
48Cardiac muscle contraction_Homo sapiens_hsa042600.96762895
49mRNA surveillance pathway_Homo sapiens_hsa030150.95135925
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91563906
51Dopaminergic synapse_Homo sapiens_hsa047280.88357873
52RNA polymerase_Homo sapiens_hsa030200.88227358
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87175770
54Hedgehog signaling pathway_Homo sapiens_hsa043400.85460558
55Notch signaling pathway_Homo sapiens_hsa043300.84686963
56RNA degradation_Homo sapiens_hsa030180.83914353
57Huntingtons disease_Homo sapiens_hsa050160.83628240
58Circadian entrainment_Homo sapiens_hsa047130.83500302
59Fatty acid metabolism_Homo sapiens_hsa012120.83166202
60Glycerolipid metabolism_Homo sapiens_hsa005610.82827817
61Axon guidance_Homo sapiens_hsa043600.79877184
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79834237
63Synaptic vesicle cycle_Homo sapiens_hsa047210.77162205
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72606064
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72154788
66Other glycan degradation_Homo sapiens_hsa005110.71560265
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69747161
68Ovarian steroidogenesis_Homo sapiens_hsa049130.68748272
69Long-term depression_Homo sapiens_hsa047300.68460475
70GABAergic synapse_Homo sapiens_hsa047270.66360072
71VEGF signaling pathway_Homo sapiens_hsa043700.66012692
72Base excision repair_Homo sapiens_hsa034100.65495782
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.60163987
74RNA transport_Homo sapiens_hsa030130.59204590
75Spliceosome_Homo sapiens_hsa030400.58954531
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58824269
77Peroxisome_Homo sapiens_hsa041460.58426663
78Choline metabolism in cancer_Homo sapiens_hsa052310.57985904
79Cholinergic synapse_Homo sapiens_hsa047250.56108923
80Amphetamine addiction_Homo sapiens_hsa050310.55195291
81Complement and coagulation cascades_Homo sapiens_hsa046100.55178540
82Thyroid hormone synthesis_Homo sapiens_hsa049180.54101408
83ErbB signaling pathway_Homo sapiens_hsa040120.53595099
84Calcium signaling pathway_Homo sapiens_hsa040200.52944892
85Alzheimers disease_Homo sapiens_hsa050100.51369721
86MAPK signaling pathway_Homo sapiens_hsa040100.50119941
87Metabolic pathways_Homo sapiens_hsa011000.49479717
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49296557
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47257962
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45064673
91Fatty acid degradation_Homo sapiens_hsa000710.39952610
92Serotonergic synapse_Homo sapiens_hsa047260.37840584
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37212213
94Bile secretion_Homo sapiens_hsa049760.32988689
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32910265
96Arachidonic acid metabolism_Homo sapiens_hsa005900.32306314
97Purine metabolism_Homo sapiens_hsa002300.30900194
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30201990
99Nucleotide excision repair_Homo sapiens_hsa034200.29296728
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27949621

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