PI4KAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration in hindbrain (GO:0021535)4.53148164
2behavioral response to nicotine (GO:0035095)4.47772182
3establishment of mitochondrion localization (GO:0051654)4.37989129
4mitochondrion transport along microtubule (GO:0047497)4.33680200
5establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.33680200
6erythrocyte maturation (GO:0043249)4.22161587
7regulation of histone H3-K4 methylation (GO:0051569)3.99592696
8genetic imprinting (GO:0071514)3.90358689
9histone H3-K4 trimethylation (GO:0080182)3.88778327
10viral transcription (GO:0019083)3.87632796
11DNA topological change (GO:0006265)3.82126679
12DNA replication checkpoint (GO:0000076)3.76682398
13histone H3-K9 methylation (GO:0051567)3.72301600
14translational termination (GO:0006415)3.67284900
15granulocyte differentiation (GO:0030851)3.45470830
16positive regulation of CREB transcription factor activity (GO:0032793)3.42753599
17ribosomal small subunit assembly (GO:0000028)3.41225378
18meiotic chromosome segregation (GO:0045132)3.39838211
19nephron epithelium morphogenesis (GO:0072088)3.37030881
20nephron tubule morphogenesis (GO:0072078)3.37030881
21homocysteine metabolic process (GO:0050667)3.36353805
22regulation of gene expression by genetic imprinting (GO:0006349)3.35100891
23DNA damage induced protein phosphorylation (GO:0006975)3.33138423
24negative regulation of histone methylation (GO:0031061)3.31860314
25DNA methylation (GO:0006306)3.27800022
26DNA alkylation (GO:0006305)3.27800022
27oxygen transport (GO:0015671)3.26392948
28histone H3-K9 modification (GO:0061647)3.26377261
29protein-DNA complex disassembly (GO:0032986)3.26260956
30nucleosome disassembly (GO:0006337)3.26260956
31DNA methylation involved in gamete generation (GO:0043046)3.24285477
32regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.20537100
33regulation of histone H3-K27 methylation (GO:0061085)3.14037312
34negative regulation of DNA-templated transcription, elongation (GO:0032785)3.12774747
35protein complex disassembly (GO:0043241)3.12438282
36phosphorelay signal transduction system (GO:0000160)3.11777225
37regulation of histone methylation (GO:0031060)3.11300830
38negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.10846318
39histone H4 deacetylation (GO:0070933)3.10138682
40gas transport (GO:0015669)3.06413685
41sensory perception of smell (GO:0007608)3.04856134
42histone lysine methylation (GO:0034968)3.03190586
43positive regulation of gene expression, epigenetic (GO:0045815)3.02851268
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01410847
45cellular protein complex disassembly (GO:0043624)2.99195596
46histone H3-K4 methylation (GO:0051568)2.98194521
47kinetochore assembly (GO:0051382)2.97830080
48regulation of translational fidelity (GO:0006450)2.97534205
49translational elongation (GO:0006414)2.97283448
50macromolecular complex disassembly (GO:0032984)2.96134910
51resolution of meiotic recombination intermediates (GO:0000712)2.96094690
52spinal cord development (GO:0021510)2.96060265
53mRNA splice site selection (GO:0006376)2.91944865
54positive regulation by host of viral transcription (GO:0043923)2.91919811
55histone H3-K9 demethylation (GO:0033169)2.90775095
56regulation of RNA export from nucleus (GO:0046831)2.90503583
57ribosomal small subunit biogenesis (GO:0042274)2.88163753
58hindbrain development (GO:0030902)2.87273970
59maturation of SSU-rRNA (GO:0030490)2.87019604
60negative regulation of erythrocyte differentiation (GO:0045647)2.83356675
61regulation of glycogen (starch) synthase activity (GO:2000465)2.81482763
62erythrocyte development (GO:0048821)2.81062185
63histone methylation (GO:0016571)2.78931855
64cell-cell junction maintenance (GO:0045217)2.78860263
65head development (GO:0060322)2.76512209
66pyrimidine dimer repair (GO:0006290)2.76429838
67regulation of hydrogen peroxide metabolic process (GO:0010310)2.74078598
68creatine metabolic process (GO:0006600)2.73107648
69cell proliferation in forebrain (GO:0021846)2.70311201
70peptidyl-lysine methylation (GO:0018022)2.69436644
71peptidyl-lysine trimethylation (GO:0018023)2.68924605
72misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.68404823
73viral life cycle (GO:0019058)2.65250653
74synapsis (GO:0007129)2.64573492
75mannose metabolic process (GO:0006013)2.62480451
76regulation of nuclear cell cycle DNA replication (GO:0033262)2.61683459
77ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.61139987
78DNA synthesis involved in DNA repair (GO:0000731)2.60038762
79histone H3 deacetylation (GO:0070932)2.59373116
80negative regulation of transcription regulatory region DNA binding (GO:2000678)2.58447351
81pyrimidine nucleobase catabolic process (GO:0006208)2.55752262
82positive regulation of megakaryocyte differentiation (GO:0045654)2.54634344
83kinetochore organization (GO:0051383)2.54506659
84reciprocal DNA recombination (GO:0035825)2.54488179
85reciprocal meiotic recombination (GO:0007131)2.54488179
86DNA methylation or demethylation (GO:0044728)2.53356361
87centriole replication (GO:0007099)2.52284003
88synaptic transmission, cholinergic (GO:0007271)2.51240036
89protoporphyrinogen IX metabolic process (GO:0046501)2.47710493
90male meiosis I (GO:0007141)2.47459561
91vitamin A metabolic process (GO:0006776)2.45787413
92neural tube development (GO:0021915)2.45554300
93response to misfolded protein (GO:0051788)2.45460841
94negative regulation of gene expression, epigenetic (GO:0045814)2.44987379
95detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.44792166
96snRNA processing (GO:0016180)2.44760920
97cerebellar Purkinje cell differentiation (GO:0021702)2.44058364
98membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.43874419
99histone deubiquitination (GO:0016578)2.42978989
100regulation of histone deacetylation (GO:0031063)2.41608174

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.47327365
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.99885965
3CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.92701965
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.79715286
5E2F7_22180533_ChIP-Seq_HELA_Human2.77703166
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.57467735
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32923661
8NCOR1_26117541_ChIP-Seq_K562_Human2.29262288
9P68_20966046_ChIP-Seq_HELA_Human2.07188529
10GATA1_19941826_ChIP-Seq_K562_Human1.93383952
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89210958
12KDM2B_26808549_Chip-Seq_K562_Human1.84012715
13LXR_22292898_ChIP-Seq_THP-1_Human1.81287859
14EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.77450959
15CTCF_27219007_Chip-Seq_Bcells_Human1.76428424
16VDR_21846776_ChIP-Seq_THP-1_Human1.74604858
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72904154
18MYC_22102868_ChIP-Seq_BL_Human1.72739233
19CIITA_25753668_ChIP-Seq_RAJI_Human1.71158988
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69965095
21REST_21632747_ChIP-Seq_MESCs_Mouse1.61018200
22PHF8_20622854_ChIP-Seq_HELA_Human1.60580527
23XRN2_22483619_ChIP-Seq_HELA_Human1.59033834
24KDM2B_26808549_Chip-Seq_DND41_Human1.58731650
25SMC4_20622854_ChIP-Seq_HELA_Human1.56512741
26E2F1_20622854_ChIP-Seq_HELA_Human1.54814789
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54645499
28SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.51694673
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.51486124
30DROSHA_22980978_ChIP-Seq_HELA_Human1.50981004
31MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.50958187
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48610374
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.48566878
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.46952224
35SA1_27219007_Chip-Seq_ERYTHROID_Human1.43486455
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.43351569
37KDM5A_27292631_Chip-Seq_BREAST_Human1.42218644
38BCL6_27268052_Chip-Seq_Bcells_Human1.42097934
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38581673
40SA1_27219007_Chip-Seq_Bcells_Human1.38204126
41ZNF274_21170338_ChIP-Seq_K562_Hela1.36868825
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35026667
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.33801320
44* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33755490
45FOXP1_21924763_ChIP-Seq_HESCs_Human1.32682854
46TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.32593333
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32391103
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31953483
49YY1_22570637_ChIP-Seq_MALME-3M_Human1.31833421
50KDM2B_26808549_Chip-Seq_JURKAT_Human1.31458588
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31407294
52CREB1_26743006_Chip-Seq_LNCaP_Human1.31397278
53SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31395107
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29590530
55OCT4_19829295_ChIP-Seq_ESCs_Human1.29157637
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28442958
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27841433
58BCOR_27268052_Chip-Seq_Bcells_Human1.27090392
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.26963086
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.26597629
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.26109233
62MAF_26560356_Chip-Seq_TH2_Human1.22638764
63ERA_21632823_ChIP-Seq_H3396_Human1.22249505
64TTF2_22483619_ChIP-Seq_HELA_Human1.21852901
65GABP_19822575_ChIP-Seq_HepG2_Human1.21755361
66E2F1_17053090_ChIP-ChIP_MCF-7_Human1.21683348
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.19510741
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18535551
69RARB_27405468_Chip-Seq_BRAIN_Mouse1.18497749
70RAC3_21632823_ChIP-Seq_H3396_Human1.16757233
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16467223
72GATA1_26923725_Chip-Seq_HPCs_Mouse1.15432436
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14536935
74CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14161644
75GATA2_19941826_ChIP-Seq_K562_Human1.13657601
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11333850
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10733999
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08080780
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08045081
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07375494
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07037990
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06650367
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06354332
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06324218
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05824910
86CTCF_20526341_ChIP-Seq_ESCs_Human1.05739609
87RARA_24833708_ChIP-Seq_LIVER_Mouse1.04411381
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03397061
89SCL_19346495_ChIP-Seq_HPC-7_Human1.01336996
90POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00784690
91NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.99554549
92YY1_21170310_ChIP-Seq_MESCs_Mouse0.97827541
93VDR_22108803_ChIP-Seq_LS180_Human0.96713421
94RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96577422
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96476483
96TCF7_22412390_ChIP-Seq_EML_Mouse0.95811013
97ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94550967
98CTCF_26484167_Chip-Seq_Bcells_Mouse0.93014724
99SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92608930
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92565150

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.88936550
2MP0008995_early_reproductive_senescence3.49796102
3MP0003122_maternal_imprinting3.35797414
4MP0004147_increased_porphyrin_level2.89814703
5MP0003787_abnormal_imprinting2.84294713
6MP0003123_paternal_imprinting2.55383172
7MP0005377_hearing/vestibular/ear_phenot2.46841785
8MP0003878_abnormal_ear_physiology2.46841785
9MP0003121_genomic_imprinting2.36301456
10MP0004859_abnormal_synaptic_plasticity2.07708304
11MP0006276_abnormal_autonomic_nervous2.01300512
12MP0003136_yellow_coat_color1.98373379
13MP0008877_abnormal_DNA_methylation1.94786723
14MP0002249_abnormal_larynx_morphology1.76584429
15MP0008058_abnormal_DNA_repair1.75272771
16MP0005394_taste/olfaction_phenotype1.75082798
17MP0005499_abnormal_olfactory_system1.75082798
18MP0000566_synostosis1.72693372
19MP0000678_abnormal_parathyroid_gland1.71872109
20MP0009278_abnormal_bone_marrow1.67000000
21MP0001502_abnormal_circadian_rhythm1.52295437
22MP0000778_abnormal_nervous_system1.51655405
23MP0005646_abnormal_pituitary_gland1.50590918
24MP0004885_abnormal_endolymph1.48635907
25MP0001968_abnormal_touch/_nociception1.47801343
26MP0003879_abnormal_hair_cell1.44984569
27MP0002822_catalepsy1.44584595
28MP0002638_abnormal_pupillary_reflex1.42948751
29MP0002653_abnormal_ependyma_morphology1.41606749
30MP0000631_abnormal_neuroendocrine_gland1.41344999
31MP0004142_abnormal_muscle_tone1.41066938
32MP0001545_abnormal_hematopoietic_system1.40590746
33MP0005397_hematopoietic_system_phenotyp1.40590746
34MP0003635_abnormal_synaptic_transmissio1.39851677
35MP0002938_white_spotting1.39644716
36MP0008789_abnormal_olfactory_epithelium1.38290683
37MP0004133_heterotaxia1.36422803
38MP0002063_abnormal_learning/memory/cond1.36358196
39MP0005083_abnormal_biliary_tract1.34477305
40MP0009379_abnormal_foot_pigmentation1.32820302
41MP0003938_abnormal_ear_development1.32171590
42MP0002557_abnormal_social/conspecific_i1.31572593
43MP0004742_abnormal_vestibular_system1.30978375
44MP0003890_abnormal_embryonic-extraembry1.30079701
45MP0002210_abnormal_sex_determination1.29432705
46MP0003942_abnormal_urinary_system1.26045014
47MP0005423_abnormal_somatic_nervous1.25986959
48MP0003698_abnormal_male_reproductive1.25637444
49MP0001348_abnormal_lacrimal_gland1.24046703
50MP0002733_abnormal_thermal_nociception1.20625265
51MP0003385_abnormal_body_wall1.19653072
52MP0001986_abnormal_taste_sensitivity1.19357329
53MP0001529_abnormal_vocalization1.19040382
54MP0003111_abnormal_nucleus_morphology1.17353055
55MP0004145_abnormal_muscle_electrophysio1.16548401
56MP0003567_abnormal_fetal_cardiomyocyte1.11777682
57MP0003861_abnormal_nervous_system1.08384826
58MP0000955_abnormal_spinal_cord1.07648354
59MP0002152_abnormal_brain_morphology1.07456738
60MP0002184_abnormal_innervation1.05205306
61MP0003786_premature_aging1.04126737
62MP0005551_abnormal_eye_electrophysiolog1.03534678
63MP0009046_muscle_twitch1.02677899
64MP0001929_abnormal_gametogenesis1.02460052
65MP0002882_abnormal_neuron_morphology1.01940669
66MP0002272_abnormal_nervous_system1.00916654
67MP0008872_abnormal_physiological_respon0.99708559
68MP0001970_abnormal_pain_threshold0.99584225
69MP0001293_anophthalmia0.97823484
70MP0003119_abnormal_digestive_system0.96821023
71MP0002572_abnormal_emotion/affect_behav0.96768208
72MP0009745_abnormal_behavioral_response0.93329159
73MP0002064_seizures0.90338566
74MP0002752_abnormal_somatic_nervous0.89992128
75MP0004811_abnormal_neuron_physiology0.88810810
76MP0001145_abnormal_male_reproductive0.88685056
77MP0005645_abnormal_hypothalamus_physiol0.87725065
78MP0000026_abnormal_inner_ear0.87499872
79MP0003880_abnormal_central_pattern0.86954594
80MP0000653_abnormal_sex_gland0.84900562
81MP0002067_abnormal_sensory_capabilities0.83843822
82MP0002095_abnormal_skin_pigmentation0.83376779
83MP0003656_abnormal_erythrocyte_physiolo0.82861559
84MP0004924_abnormal_behavior0.81753721
85MP0005386_behavior/neurological_phenoty0.81753721
86MP0008775_abnormal_heart_ventricle0.80863218
87MP0002161_abnormal_fertility/fecundity0.80215015
88MP0008770_decreased_survivor_rate0.79272460
89MP0000015_abnormal_ear_pigmentation0.79019160
90MP0000049_abnormal_middle_ear0.78072440
91MP0003172_abnormal_lysosome_physiology0.76640253
92MP0001188_hyperpigmentation0.76225085
93MP0002132_abnormal_respiratory_system0.75687498
94MP0003646_muscle_fatigue0.75255359
95MP0001486_abnormal_startle_reflex0.75159882
96MP0010094_abnormal_chromosome_stability0.74798364
97MP0004043_abnormal_pH_regulation0.74469390
98MP0005636_abnormal_mineral_homeostasis0.71404896
99MP0002734_abnormal_mechanical_nocicepti0.70978098
100MP0001963_abnormal_hearing_physiology0.70372000

Predicted human phenotypes

RankGene SetZ-score
1Truncus arteriosus (HP:0001660)5.37514774
2Hyperthyroidism (HP:0000836)4.95198910
3Reticulocytosis (HP:0001923)3.97273397
4Abnormality of reticulocytes (HP:0004312)3.86702899
5Reticulocytopenia (HP:0001896)3.64387403
6Abnormality of DNA repair (HP:0003254)3.60267456
7Abnormality of the aortic arch (HP:0012303)3.52370959
8Abnormality of the heme biosynthetic pathway (HP:0010472)3.03891126
9Bowel incontinence (HP:0002607)3.00920080
10Abnormality of cochlea (HP:0000375)2.97172298
11Hypoparathyroidism (HP:0000829)2.89446151
12Seborrheic dermatitis (HP:0001051)2.83780545
13Rib fusion (HP:0000902)2.81511604
14Pallor (HP:0000980)2.81311275
15Abnormal large intestine physiology (HP:0012700)2.80042138
16Cholecystitis (HP:0001082)2.78040079
17Abnormal gallbladder physiology (HP:0012438)2.78040079
18Abnormality of cells of the erythroid lineage (HP:0012130)2.75974788
19Atelectasis (HP:0100750)2.65626377
20Hypoplastic iliac wings (HP:0002866)2.60012262
21Abnormal number of erythroid precursors (HP:0012131)2.56170591
22Morphological abnormality of the inner ear (HP:0011390)2.56047363
23Cerebellar dysplasia (HP:0007033)2.54263495
24Aplasia/Hypoplasia of the earlobes (HP:0009906)2.51517381
25Type II lissencephaly (HP:0007260)2.51456569
26Birth length less than 3rd percentile (HP:0003561)2.47603304
27Abnormality of homocysteine metabolism (HP:0010919)2.45058760
28Homocystinuria (HP:0002156)2.45058760
29High anterior hairline (HP:0009890)2.43225836
30Duplicated collecting system (HP:0000081)2.41491909
31Polydipsia (HP:0001959)2.40354939
32Abnormal drinking behavior (HP:0030082)2.40354939
33Abnormality of the labia minora (HP:0012880)2.36691235
34Hypertensive crisis (HP:0100735)2.35474557
35Abnormal hemoglobin (HP:0011902)2.35041191
36Diastasis recti (HP:0001540)2.33238965
37Abnormality of the renal collecting system (HP:0004742)2.30279974
38Deep palmar crease (HP:0006191)2.28386033
39Aplasia/Hypoplasia of the spleen (HP:0010451)2.25623124
40Patellar aplasia (HP:0006443)2.24169224
41Abnormally folded helix (HP:0008544)2.21940130
42Protruding tongue (HP:0010808)2.17119261
43Nephronophthisis (HP:0000090)2.15655939
44Chromsome breakage (HP:0040012)2.10321534
45Ectopic kidney (HP:0000086)2.09191577
46Asplenia (HP:0001746)2.07252891
47Aplasia/Hypoplasia of the patella (HP:0006498)2.06327725
48Pachygyria (HP:0001302)2.00417098
49Tetany (HP:0001281)1.98094121
50Impulsivity (HP:0100710)1.96471524
51Abnormal hair whorl (HP:0010721)1.95652122
52Hypomagnesemia (HP:0002917)1.95301491
53Horseshoe kidney (HP:0000085)1.95003148
54Disproportionate tall stature (HP:0001519)1.94173397
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93905191
56Obsessive-compulsive behavior (HP:0000722)1.93082065
57Flat cornea (HP:0007720)1.93024041
58Polyuria (HP:0000103)1.91500083
59Cheekbone underdevelopment (HP:0010669)1.91358183
60Facial hemangioma (HP:0000329)1.90498756
61Optic nerve coloboma (HP:0000588)1.90188552
62Pointed chin (HP:0000307)1.89611107
63Poikilocytosis (HP:0004447)1.89511180
64Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89284884
65Abnormality of the fingertips (HP:0001211)1.89232135
66Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87964508
67Hypoplasia of the brainstem (HP:0002365)1.87964508
68Severe Myopia (HP:0011003)1.87681028
69Poikiloderma (HP:0001029)1.86098705
70Patellar dislocation (HP:0002999)1.85294737
71Polycystic kidney dysplasia (HP:0000113)1.84160367
72Pancreatic fibrosis (HP:0100732)1.84092060
73Epileptic encephalopathy (HP:0200134)1.81619901
74Abnormality of midbrain morphology (HP:0002418)1.81030395
75Molar tooth sign on MRI (HP:0002419)1.81030395
76Lissencephaly (HP:0001339)1.79633565
77Attention deficit hyperactivity disorder (HP:0007018)1.78867912
78Retinal dysplasia (HP:0007973)1.77562828
79Aplasia/Hypoplasia of the sternum (HP:0006714)1.77279803
80Ileus (HP:0002595)1.76189190
81Severe visual impairment (HP:0001141)1.75796603
82Abnormality of dental color (HP:0011073)1.74982354
83Broad palm (HP:0001169)1.74572322
84Entropion (HP:0000621)1.74423224
85Hypoplasia of the pons (HP:0012110)1.72965328
86Overfolded helix (HP:0000396)1.72397303
87Supernumerary bones of the axial skeleton (HP:0009144)1.72250605
88Abnormality of magnesium homeostasis (HP:0004921)1.72183839
89Prominent nasal bridge (HP:0000426)1.69023094
90Enlarged kidneys (HP:0000105)1.68941587
91Abnormality of the renal medulla (HP:0100957)1.68046872
92Broad alveolar ridges (HP:0000187)1.67287598
9311 pairs of ribs (HP:0000878)1.66680381
94Aplasia/Hypoplasia of the thymus (HP:0010515)1.66345105
95Cortical dysplasia (HP:0002539)1.66340479
96Macrocytic anemia (HP:0001972)1.65970867
97Severe muscular hypotonia (HP:0006829)1.65495455
98Heterotopia (HP:0002282)1.65125678
99Poor coordination (HP:0002370)1.65112969
100Annular pancreas (HP:0001734)1.64432911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.89304825
2SIK23.18706861
3NTRK33.13584909
4STK162.72534272
5STK392.37939700
6TYRO32.13591694
7EEF2K2.10721450
8ICK2.00975628
9TAOK31.88135170
10RIPK41.77175790
11MARK11.72964415
12NTRK21.70946669
13WNK11.65838580
14NME11.57998593
15PLK41.53215983
16MARK21.50579293
17MAP3K71.49488963
18CDK121.47012853
19OXSR11.45156175
20KSR21.43560497
21MAPK131.42925924
22CAMK1D1.41009483
23MAP3K41.39879302
24FGFR21.29184535
25CLK11.23462109
26NEK21.22321746
27CDC71.20234025
28MAPK151.18533945
29KSR11.16838717
30TRIB31.16718516
31RAF11.12489658
32TNIK1.11106975
33CAMK1G1.07576442
34BMX1.00644307
35MARK30.99484351
36PDK20.98397075
37DYRK20.96014516
38FGFR40.93752434
39CASK0.93445686
40TNK20.93300336
41MTOR0.90335108
42CAMKK10.89715626
43ATR0.88514026
44MAP2K40.86571511
45PRKAA10.82751418
46WNK30.78694426
47CDK20.74627619
48CAMK10.74337762
49MAP3K20.73271968
50CHEK20.72907182
51MAP4K20.71288831
52CDK10.70197348
53ERBB20.69787370
54DYRK1B0.69714737
55PTK60.67292504
56INSRR0.66768259
57SGK10.66646545
58DMPK0.64133384
59PRKCH0.63533238
60MAP3K90.62414403
61GSK3B0.62410704
62MAPK120.62360174
63CHEK10.61426845
64BMPR1B0.61240753
65MAP2K60.61134205
66CSNK1E0.60472687
67AKT10.60096746
68TTK0.59416574
69PKN20.59279997
70PRKD30.57914939
71ZAK0.57310361
72RPS6KA20.56868213
73RET0.56614997
74MAPK80.56086545
75MAP4K10.54572920
76WEE10.54495103
77BRD40.54409353
78RPS6KA60.54201757
79DAPK20.52268463
80STK110.52036033
81MAPK140.51047625
82CAMK40.50319608
83BRSK10.49347582
84ATM0.48521672
85DYRK1A0.47838612
86PKN10.47299316
87MAP2K20.46715519
88PRKDC0.46685430
89MAPK30.46519005
90PRKD20.46272681
91MAPK10.46252317
92PIM10.45172239
93BTK0.43449952
94SIK10.43347935
95MAPK100.42212649
96MAP3K60.42128922
97PRKAA20.42076299
98RPS6KL10.41222208
99RPS6KC10.41222208
100MAP2K70.40426328

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.87956697
2Homologous recombination_Homo sapiens_hsa034402.83560275
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.55640890
4Nicotine addiction_Homo sapiens_hsa050332.48819288
5Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.42746497
6Fanconi anemia pathway_Homo sapiens_hsa034602.32270316
7Olfactory transduction_Homo sapiens_hsa047402.09855714
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07919772
9Steroid biosynthesis_Homo sapiens_hsa001001.95119077
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79143849
11Notch signaling pathway_Homo sapiens_hsa043301.70261771
12Basal transcription factors_Homo sapiens_hsa030221.69392914
13mRNA surveillance pathway_Homo sapiens_hsa030151.63791228
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63328449
15Lysine degradation_Homo sapiens_hsa003101.62090406
16Synaptic vesicle cycle_Homo sapiens_hsa047211.59627193
17One carbon pool by folate_Homo sapiens_hsa006701.59505308
18Base excision repair_Homo sapiens_hsa034101.57577928
19Type II diabetes mellitus_Homo sapiens_hsa049301.47461897
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.40776645
21Ether lipid metabolism_Homo sapiens_hsa005651.40055472
22Nucleotide excision repair_Homo sapiens_hsa034201.36793951
23ErbB signaling pathway_Homo sapiens_hsa040121.36519276
24VEGF signaling pathway_Homo sapiens_hsa043701.36039989
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.30029473
26DNA replication_Homo sapiens_hsa030301.28290586
27Morphine addiction_Homo sapiens_hsa050321.27384752
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25682915
29RNA transport_Homo sapiens_hsa030131.23368294
30Acute myeloid leukemia_Homo sapiens_hsa052211.20731452
31Linoleic acid metabolism_Homo sapiens_hsa005911.15009150
32Collecting duct acid secretion_Homo sapiens_hsa049661.14079814
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14050712
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07633451
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.05920470
36Insulin secretion_Homo sapiens_hsa049111.04642684
37ABC transporters_Homo sapiens_hsa020101.03959873
38Spliceosome_Homo sapiens_hsa030401.02786900
39GABAergic synapse_Homo sapiens_hsa047271.01323283
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00985077
41Cholinergic synapse_Homo sapiens_hsa047251.00660073
42Sulfur relay system_Homo sapiens_hsa041220.99158907
43Choline metabolism in cancer_Homo sapiens_hsa052310.98518174
44Mismatch repair_Homo sapiens_hsa034300.96019234
45Glutamatergic synapse_Homo sapiens_hsa047240.95058623
46Other glycan degradation_Homo sapiens_hsa005110.92252463
47Circadian entrainment_Homo sapiens_hsa047130.91851810
48Inositol phosphate metabolism_Homo sapiens_hsa005620.91291029
49RNA degradation_Homo sapiens_hsa030180.91204310
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88801443
51mTOR signaling pathway_Homo sapiens_hsa041500.86571794
52Fat digestion and absorption_Homo sapiens_hsa049750.85877923
53Selenocompound metabolism_Homo sapiens_hsa004500.85845136
54Butanoate metabolism_Homo sapiens_hsa006500.85135691
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85134657
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84066077
57Basal cell carcinoma_Homo sapiens_hsa052170.81218146
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79676948
59RNA polymerase_Homo sapiens_hsa030200.78773078
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77729672
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77514375
62Axon guidance_Homo sapiens_hsa043600.77428666
63Taste transduction_Homo sapiens_hsa047420.75293577
64Cardiac muscle contraction_Homo sapiens_hsa042600.74322769
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70731034
66Phototransduction_Homo sapiens_hsa047440.69858847
67Insulin signaling pathway_Homo sapiens_hsa049100.68439599
68Dorso-ventral axis formation_Homo sapiens_hsa043200.68364037
69MAPK signaling pathway_Homo sapiens_hsa040100.67424420
70Chronic myeloid leukemia_Homo sapiens_hsa052200.66813557
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.66396016
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.64963899
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64923087
74Cell cycle_Homo sapiens_hsa041100.63609280
75Dopaminergic synapse_Homo sapiens_hsa047280.63484201
76Regulation of autophagy_Homo sapiens_hsa041400.63173476
77Non-small cell lung cancer_Homo sapiens_hsa052230.62646131
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61373731
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60338075
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60317183
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.60248289
82Prolactin signaling pathway_Homo sapiens_hsa049170.60239116
83Fructose and mannose metabolism_Homo sapiens_hsa000510.59329799
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59087970
85AMPK signaling pathway_Homo sapiens_hsa041520.58529550
86Oxidative phosphorylation_Homo sapiens_hsa001900.58383132
87Nitrogen metabolism_Homo sapiens_hsa009100.58321126
88Melanogenesis_Homo sapiens_hsa049160.58261235
89Fatty acid metabolism_Homo sapiens_hsa012120.58209275
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57832402
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56165321
92HIF-1 signaling pathway_Homo sapiens_hsa040660.52931036
93GnRH signaling pathway_Homo sapiens_hsa049120.52772253
94Hedgehog signaling pathway_Homo sapiens_hsa043400.52713297
95Long-term depression_Homo sapiens_hsa047300.51917021
96Cocaine addiction_Homo sapiens_hsa050300.51123355
97Huntingtons disease_Homo sapiens_hsa050160.47776134
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46995725
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46281850
100Parkinsons disease_Homo sapiens_hsa050120.46022069

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