PIANP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ligand for the paired immunoglobin-like type 2 receptor alpha, and so may be involved in immune regulation. Alternate splicing results in multiple transcript variants encoding different proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.93055439
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.42779907
3locomotory exploration behavior (GO:0035641)6.00635865
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.80762683
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.64313595
6synaptic vesicle exocytosis (GO:0016079)5.49855054
7glutamate secretion (GO:0014047)5.43058364
8vocalization behavior (GO:0071625)5.37935986
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.20874403
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.20161789
11regulation of synaptic vesicle exocytosis (GO:2000300)5.16424017
12regulation of glutamate receptor signaling pathway (GO:1900449)4.95577252
13neurotransmitter secretion (GO:0007269)4.73637389
14regulation of synaptic vesicle transport (GO:1902803)4.64885673
15regulation of neuronal synaptic plasticity (GO:0048168)4.56964803
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.56139179
17exploration behavior (GO:0035640)4.54826789
18proline transport (GO:0015824)4.54099697
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.50633436
20regulation of synapse structural plasticity (GO:0051823)4.46369752
21protein localization to synapse (GO:0035418)4.45912370
22neuronal action potential propagation (GO:0019227)4.41409305
23cerebellar granule cell differentiation (GO:0021707)4.30747302
24L-amino acid import (GO:0043092)4.22755239
25synaptic transmission, glutamatergic (GO:0035249)4.11948791
26neuron cell-cell adhesion (GO:0007158)4.10418865
27layer formation in cerebral cortex (GO:0021819)4.06631074
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.05965694
29gamma-aminobutyric acid transport (GO:0015812)4.04881658
30long-term memory (GO:0007616)4.02696819
31presynaptic membrane assembly (GO:0097105)4.01606865
32presynaptic membrane organization (GO:0097090)3.96427872
33positive regulation of dendritic spine development (GO:0060999)3.93751204
34dendritic spine morphogenesis (GO:0060997)3.92712427
35positive regulation of synaptic transmission, GABAergic (GO:0032230)3.89728007
36axon ensheathment in central nervous system (GO:0032291)3.89028885
37central nervous system myelination (GO:0022010)3.89028885
38neuron-neuron synaptic transmission (GO:0007270)3.87904240
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.87437925
40cellular potassium ion homeostasis (GO:0030007)3.85515852
41neurotransmitter-gated ion channel clustering (GO:0072578)3.84268738
42amino acid import (GO:0043090)3.83182902
43glutamate receptor signaling pathway (GO:0007215)3.82960012
44neurotransmitter transport (GO:0006836)3.81278485
45neuromuscular process controlling posture (GO:0050884)3.80023579
46regulation of voltage-gated calcium channel activity (GO:1901385)3.78390735
47positive regulation of membrane potential (GO:0045838)3.77138894
48activation of protein kinase A activity (GO:0034199)3.77063473
49potassium ion homeostasis (GO:0055075)3.72997921
50positive regulation of dendritic spine morphogenesis (GO:0061003)3.71513288
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71109589
52sodium ion export (GO:0071436)3.70689517
53positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.67269128
54potassium ion import (GO:0010107)3.64023289
55regulation of synaptic plasticity (GO:0048167)3.60404182
56neuromuscular process controlling balance (GO:0050885)3.60021415
57positive regulation of synapse maturation (GO:0090129)3.57691441
58regulation of neurotransmitter levels (GO:0001505)3.55502183
59regulation of postsynaptic membrane potential (GO:0060078)3.54307425
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.54127215
61cell migration in hindbrain (GO:0021535)3.53782198
62auditory behavior (GO:0031223)3.48406363
63regulation of synapse maturation (GO:0090128)3.47846845
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.47495570
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47055995
66neuromuscular synaptic transmission (GO:0007274)3.46087645
67prepulse inhibition (GO:0060134)3.45687479
68regulation of dendritic spine morphogenesis (GO:0061001)3.44863353
69regulation of neurotransmitter secretion (GO:0046928)3.42862144
70long-term synaptic potentiation (GO:0060291)3.40722099
71synaptic vesicle endocytosis (GO:0048488)3.37437954
72positive regulation of neurotransmitter transport (GO:0051590)3.36394390
73cerebellar Purkinje cell differentiation (GO:0021702)3.33688592
74response to auditory stimulus (GO:0010996)3.32505920
75regulation of dendritic spine development (GO:0060998)3.32383293
76establishment of mitochondrion localization (GO:0051654)3.31859334
77cell communication by electrical coupling (GO:0010644)3.28436051
78negative regulation of dendrite morphogenesis (GO:0050774)3.27823951
79glycine transport (GO:0015816)3.26942189
80transmission of nerve impulse (GO:0019226)3.26183349
81regulation of synaptic transmission, glutamatergic (GO:0051966)3.25869839
82regulation of vesicle fusion (GO:0031338)3.23736638
83positive regulation of neurotransmitter secretion (GO:0001956)3.23154547
84cellular sodium ion homeostasis (GO:0006883)3.22620700
85regulation of neurotransmitter transport (GO:0051588)3.22558897
86G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.21419828
87neuronal ion channel clustering (GO:0045161)3.15725242
88behavioral fear response (GO:0001662)3.14416180
89behavioral defense response (GO:0002209)3.14416180
90neuron recognition (GO:0008038)3.13991159
91positive regulation of synaptic transmission (GO:0050806)3.12070517
92acidic amino acid transport (GO:0015800)3.11236243
93mechanosensory behavior (GO:0007638)3.09032402
94cerebellar Purkinje cell layer development (GO:0021680)3.07535409
95synaptic vesicle transport (GO:0048489)3.07131863
96establishment of synaptic vesicle localization (GO:0097480)3.07131863
97striatum development (GO:0021756)3.06961666
98membrane hyperpolarization (GO:0060081)3.06068793
99membrane depolarization (GO:0051899)3.05455806
100membrane depolarization during action potential (GO:0086010)3.05191390
101negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04462911
102vesicle transport along microtubule (GO:0047496)3.03200404
103neuromuscular process (GO:0050905)3.00715660
104gamma-aminobutyric acid signaling pathway (GO:0007214)3.00079243
105regulation of synaptic transmission (GO:0050804)2.99013607
106learning (GO:0007612)2.98982541
107fear response (GO:0042596)2.98693506
108negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.97597252
109mating behavior (GO:0007617)2.96939695
110positive regulation of synapse assembly (GO:0051965)2.96596142
111chemosensory behavior (GO:0007635)2.94776254
112cell differentiation in hindbrain (GO:0021533)2.94708825
113adult walking behavior (GO:0007628)2.94643414
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94584810
115regulation of glutamate secretion (GO:0014048)2.94360549
116dendritic spine organization (GO:0097061)2.93990714
117synaptic transmission (GO:0007268)2.93818331
118regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92008756
119response to histamine (GO:0034776)2.91447395
120axonal fasciculation (GO:0007413)2.90683678
121regulation of ARF protein signal transduction (GO:0032012)2.89679796
122dendrite morphogenesis (GO:0048813)2.88207193
123regulation of synaptic transmission, GABAergic (GO:0032228)2.87988370
124postsynaptic membrane organization (GO:0001941)2.87817405
125social behavior (GO:0035176)2.87040119
126intraspecies interaction between organisms (GO:0051703)2.87040119

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.84068144
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17142467
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.13380278
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07261848
5REST_21632747_ChIP-Seq_MESCs_Mouse2.95982238
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94266254
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82835007
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82835007
9GBX2_23144817_ChIP-Seq_PC3_Human2.77809421
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69797507
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.60059779
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59910355
13DROSHA_22980978_ChIP-Seq_HELA_Human2.59704929
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56489047
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56170020
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53669538
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.52767938
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.51904027
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.47521275
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.41319687
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40512735
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30130270
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.28460220
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.25976711
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.21987008
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.09396627
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02384025
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02018762
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.94100176
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87760021
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65860884
32RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.64975875
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57646473
34AR_21572438_ChIP-Seq_LNCaP_Human1.55224314
35KDM2B_26808549_Chip-Seq_K562_Human1.47732697
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.40945262
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40626608
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38523625
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37041178
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.35675201
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35301375
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35253442
43SMAD4_21799915_ChIP-Seq_A2780_Human1.33996770
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33614386
45OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.30917388
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28578983
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27857496
48* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25559392
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.24085699
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.22819260
51AR_19668381_ChIP-Seq_PC3_Human1.22780573
52ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22444920
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22150748
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20396745
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16665240
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16527691
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13489480
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13428783
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12264874
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07901379
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06660478
62STAT3_23295773_ChIP-Seq_U87_Human1.06341350
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04813913
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04484070
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04458032
66TET1_21490601_ChIP-Seq_MESCs_Mouse1.04404008
67ZNF274_21170338_ChIP-Seq_K562_Hela1.02754434
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99569853
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98604279
70CTCF_27219007_Chip-Seq_Bcells_Human0.98227884
71MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98108321
72KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97305419
73YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97026835
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97025266
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97025266
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96473767
77RNF2_27304074_Chip-Seq_NSC_Mouse0.96247017
78AR_25329375_ChIP-Seq_VCAP_Human0.95977942
79SMAD3_21741376_ChIP-Seq_HESCs_Human0.95909364
80TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95861543
81BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93351240
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93286010
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92573422
84SMC4_20622854_ChIP-Seq_HELA_Human0.92445131
85TAF15_26573619_Chip-Seq_HEK293_Human0.92099160
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92028063
87AHR_22903824_ChIP-Seq_MCF-7_Human0.91518014
88ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91130958
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.90783494
90SMAD4_21741376_ChIP-Seq_HESCs_Human0.89936972
91SMAD_19615063_ChIP-ChIP_OVARY_Human0.89452070
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89119170
93SMAD3_21741376_ChIP-Seq_EPCs_Human0.89039795
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88795830
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87055109
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86931192
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86639127
98SOX9_26525672_Chip-Seq_HEART_Mouse0.85958431
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.85926880
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85247189
101TP53_20018659_ChIP-ChIP_R1E_Mouse0.85189539
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84890067
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84399548
104CBX2_27304074_Chip-Seq_ESCs_Mouse0.83809600
105TCF4_23295773_ChIP-Seq_U87_Human0.82805717
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82601938
107DPY_21335234_ChIP-Seq_ESCs_Mouse0.82046242
108P300_19829295_ChIP-Seq_ESCs_Human0.81966141
109LXR_22292898_ChIP-Seq_THP-1_Human0.81082039
110KLF4_19829295_ChIP-Seq_ESCs_Human0.80894985
111IGF1R_20145208_ChIP-Seq_DFB_Human0.80805468
112RXR_22108803_ChIP-Seq_LS180_Human0.80370712
113OCT4_19829295_ChIP-Seq_ESCs_Human0.80305900
114NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77523491
115RUNX1_26923725_Chip-Seq_HPCs_Mouse0.77117347
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.76654227
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76378237
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76360170
119RUNX2_22187159_ChIP-Seq_PCA_Human0.75685597
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74419834
121POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.73894760
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72204587
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.71951689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.72651494
2MP0003880_abnormal_central_pattern4.42889811
3MP0003635_abnormal_synaptic_transmissio4.19979477
4MP0004270_analgesia3.65041867
5MP0002822_catalepsy3.48852378
6MP0009745_abnormal_behavioral_response3.38412359
7MP0002063_abnormal_learning/memory/cond3.32197322
8MP0002064_seizures3.22828316
9MP0009046_muscle_twitch3.22195383
10MP0002572_abnormal_emotion/affect_behav2.88282031
11MP0005423_abnormal_somatic_nervous2.82915248
12MP0001968_abnormal_touch/_nociception2.70550772
13MP0002272_abnormal_nervous_system2.54397941
14MP0001486_abnormal_startle_reflex2.53451925
15MP0002734_abnormal_mechanical_nocicepti2.48315503
16MP0004858_abnormal_nervous_system2.37768820
17MP0001501_abnormal_sleep_pattern2.36799944
18MP0002909_abnormal_adrenal_gland2.24394435
19MP0002733_abnormal_thermal_nociception2.05466995
20MP0003122_maternal_imprinting2.05276664
21MP0001440_abnormal_grooming_behavior1.97248729
22MP0001970_abnormal_pain_threshold1.94609428
23MP0002736_abnormal_nociception_after1.88535027
24MP0008569_lethality_at_weaning1.88316684
25MP0002067_abnormal_sensory_capabilities1.78024757
26MP0009780_abnormal_chondrocyte_physiolo1.77411776
27MP0004811_abnormal_neuron_physiology1.77113407
28MP0002735_abnormal_chemical_nociception1.76875287
29MP0004924_abnormal_behavior1.70513675
30MP0005386_behavior/neurological_phenoty1.70513675
31MP0005646_abnormal_pituitary_gland1.68432592
32MP0003787_abnormal_imprinting1.68255060
33MP0002557_abnormal_social/conspecific_i1.68146179
34MP0002184_abnormal_innervation1.67563426
35MP0003329_amyloid_beta_deposits1.63978209
36MP0000955_abnormal_spinal_cord1.55218409
37MP0008961_abnormal_basal_metabolism1.50752545
38MP0003879_abnormal_hair_cell1.49334791
39MP0003283_abnormal_digestive_organ1.49256095
40MP0006276_abnormal_autonomic_nervous1.46970575
41MP0000778_abnormal_nervous_system1.42867725
42MP0004885_abnormal_endolymph1.38521381
43MP0002066_abnormal_motor_capabilities/c1.38280122
44MP0002882_abnormal_neuron_morphology1.34528337
45MP0001984_abnormal_olfaction1.32143598
46MP0003633_abnormal_nervous_system1.31046252
47MP0001529_abnormal_vocalization1.29932856
48MP0005645_abnormal_hypothalamus_physiol1.27942259
49MP0005499_abnormal_olfactory_system1.27904051
50MP0005394_taste/olfaction_phenotype1.27904051
51MP0004142_abnormal_muscle_tone1.21551985
52MP0001905_abnormal_dopamine_level1.20218975
53MP0000566_synostosis1.16383313
54MP0002638_abnormal_pupillary_reflex1.15519253
55MP0008872_abnormal_physiological_respon1.13155102
56MP0001502_abnormal_circadian_rhythm1.11197651
57MP0008877_abnormal_DNA_methylation1.10445296
58MP0003631_nervous_system_phenotype1.05441293
59MP0003075_altered_response_to1.03631850
60MP0001346_abnormal_lacrimal_gland1.02930964
61MP0000751_myopathy1.02712355
62MP0002152_abnormal_brain_morphology1.02222155
63MP0002069_abnormal_eating/drinking_beha0.96865178
64MP0008874_decreased_physiological_sensi0.96853987
65MP0000013_abnormal_adipose_tissue0.96397767
66MP0004085_abnormal_heartbeat0.94965309
67MP0010386_abnormal_urinary_bladder0.93789721
68MP0003172_abnormal_lysosome_physiology0.92858591
69MP0002229_neurodegeneration0.92346765
70MP0001485_abnormal_pinna_reflex0.91048657
71MP0004145_abnormal_muscle_electrophysio0.90148273
72MP0004043_abnormal_pH_regulation0.89093738
73MP0005167_abnormal_blood-brain_barrier0.89080998
74MP0003938_abnormal_ear_development0.87035850
75MP0005535_abnormal_body_temperature0.86772528
76MP0003123_paternal_imprinting0.85181293
77MP0003690_abnormal_glial_cell0.84203114
78MP0003634_abnormal_glial_cell0.81897350
79MP0000026_abnormal_inner_ear0.81156167
80MP0001177_atelectasis0.78197629
81MP0003137_abnormal_impulse_conducting0.77577850
82MP0003632_abnormal_nervous_system0.77346642
83MP0003121_genomic_imprinting0.76911773
84MP0002090_abnormal_vision0.75651653
85MP0000631_abnormal_neuroendocrine_gland0.74428223
86MP0003183_abnormal_peptide_metabolism0.73725058
87MP0001986_abnormal_taste_sensitivity0.72966197
88MP0001299_abnormal_eye_distance/0.72391555
89MP0002837_dystrophic_cardiac_calcinosis0.71928855
90MP0005551_abnormal_eye_electrophysiolog0.71918845
91MP0000569_abnormal_digit_pigmentation0.71046897
92MP0004147_increased_porphyrin_level0.70160344
93MP0000920_abnormal_myelination0.69277080
94MP0002653_abnormal_ependyma_morphology0.68746201
95MP0000579_abnormal_nail_morphology0.68728939
96MP0001188_hyperpigmentation0.67280872
97MP0006292_abnormal_olfactory_placode0.67261231
98MP0000604_amyloidosis0.66757279
99MP0002752_abnormal_somatic_nervous0.66687450
100MP0005623_abnormal_meninges_morphology0.66500586
101MP0001963_abnormal_hearing_physiology0.65152598
102MP0004215_abnormal_myocardial_fiber0.64958796
103MP0002249_abnormal_larynx_morphology0.63562682
104MP0001348_abnormal_lacrimal_gland0.62797724
105MP0010234_abnormal_vibrissa_follicle0.59877539
106MP0010770_preweaning_lethality0.58780193
107MP0002082_postnatal_lethality0.58780193
108MP0010768_mortality/aging0.57061282
109MP0001943_abnormal_respiration0.55585777
110MP0009379_abnormal_foot_pigmentation0.53379191
111MP0008789_abnormal_olfactory_epithelium0.52701423
112MP0001664_abnormal_digestion0.52691244
113MP0010769_abnormal_survival0.52514947
114MP0004233_abnormal_muscle_weight0.52094673
115MP0002081_perinatal_lethality0.51285005
116MP0004130_abnormal_muscle_cell0.50578939
117MP0004742_abnormal_vestibular_system0.49912280
118MP0003956_abnormal_body_size0.49902851
119MP0004510_myositis0.49815902
120MP0003861_abnormal_nervous_system0.49701319

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.13061871
2Focal motor seizures (HP:0011153)7.11433496
3Focal seizures (HP:0007359)5.67118131
4Visual hallucinations (HP:0002367)5.41626853
5Epileptic encephalopathy (HP:0200134)4.68077133
6Febrile seizures (HP:0002373)4.36753210
7Atonic seizures (HP:0010819)4.26877065
8Abnormality of the lower motor neuron (HP:0002366)4.02557129
9Absence seizures (HP:0002121)3.93241257
10Progressive cerebellar ataxia (HP:0002073)3.87649300
11Generalized tonic-clonic seizures (HP:0002069)3.84693054
12Action tremor (HP:0002345)3.82211024
13Dialeptic seizures (HP:0011146)3.74259687
14Supranuclear gaze palsy (HP:0000605)3.56823963
15Depression (HP:0000716)3.52775391
16Ankle clonus (HP:0011448)3.39180427
17Poor eye contact (HP:0000817)3.19754524
18Amblyopia (HP:0000646)3.13229563
19Dysdiadochokinesis (HP:0002075)3.10354457
20Impaired vibration sensation in the lower limbs (HP:0002166)3.09244384
21Hyperventilation (HP:0002883)3.07757432
22Papilledema (HP:0001085)3.06966152
23Postural instability (HP:0002172)3.04422485
24Anxiety (HP:0000739)3.02755863
25Cerebral hypomyelination (HP:0006808)3.01167003
26Broad-based gait (HP:0002136)2.99650078
27Impaired social interactions (HP:0000735)2.94350680
28Abnormal social behavior (HP:0012433)2.94350680
29Gaze-evoked nystagmus (HP:0000640)2.91710852
30Abnormal eating behavior (HP:0100738)2.88691569
31Dysmetria (HP:0001310)2.88436487
32Urinary bladder sphincter dysfunction (HP:0002839)2.87902432
33Sleep apnea (HP:0010535)2.79686279
34Torticollis (HP:0000473)2.74957411
35Mutism (HP:0002300)2.74411397
36Hemiparesis (HP:0001269)2.72972693
37Akinesia (HP:0002304)2.69386713
38Annular pancreas (HP:0001734)2.68750806
39Truncal ataxia (HP:0002078)2.65872511
40Delusions (HP:0000746)2.65463325
41Bradykinesia (HP:0002067)2.60581370
42Genetic anticipation (HP:0003743)2.60150539
43Ventricular fibrillation (HP:0001663)2.59573731
44Resting tremor (HP:0002322)2.57080897
45Peripheral hypomyelination (HP:0007182)2.55750239
46Impaired smooth pursuit (HP:0007772)2.53739356
47Focal dystonia (HP:0004373)2.52261897
48Hemiplegia (HP:0002301)2.51623473
49Status epilepticus (HP:0002133)2.50930812
50Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.48661725
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.48661725
52Excessive salivation (HP:0003781)2.42111865
53Drooling (HP:0002307)2.42111865
54Intention tremor (HP:0002080)2.41743284
55Urinary urgency (HP:0000012)2.40355237
56Spastic gait (HP:0002064)2.39544208
57Abnormality of ocular smooth pursuit (HP:0000617)2.37836866
58Stereotypic behavior (HP:0000733)2.36347347
59Neoplasm of the heart (HP:0100544)2.36302626
60Limb dystonia (HP:0002451)2.34047246
61Amyotrophic lateral sclerosis (HP:0007354)2.32639083
62Failure to thrive in infancy (HP:0001531)2.31035487
63Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.29542421
64Craniofacial dystonia (HP:0012179)2.24760754
65Neuronal loss in central nervous system (HP:0002529)2.24532431
66Tetraplegia (HP:0002445)2.23748304
67Morphological abnormality of the pyramidal tract (HP:0002062)2.21312248
68Dysmetric saccades (HP:0000641)2.19565462
69Abnormality of binocular vision (HP:0011514)2.16392120
70Diplopia (HP:0000651)2.16392120
71Impaired vibratory sensation (HP:0002495)2.16090800
72Ankyloglossia (HP:0010296)2.15973432
73Pointed chin (HP:0000307)2.15807091
74Split foot (HP:0001839)2.15193356
75Scanning speech (HP:0002168)2.12999547
76Absent speech (HP:0001344)2.12943991
77Generalized hypotonia (HP:0001290)2.12594159
78Spastic tetraparesis (HP:0001285)2.12346621
79Cerebral inclusion bodies (HP:0100314)2.11864389
80Neurofibrillary tangles (HP:0002185)2.10049370
81Pheochromocytoma (HP:0002666)2.09256247
82Generalized myoclonic seizures (HP:0002123)2.08311219
83Lower limb muscle weakness (HP:0007340)2.08034648
84Abnormal EKG (HP:0003115)2.03962028
85Choreoathetosis (HP:0001266)2.03477308
86Epileptiform EEG discharges (HP:0011182)2.03415227
87Abnormality of the corticospinal tract (HP:0002492)2.02339212
88Rapidly progressive (HP:0003678)2.02164000
89CNS hypomyelination (HP:0003429)2.01035220
90Progressive inability to walk (HP:0002505)2.00334688
91Diminished motivation (HP:0000745)2.00303542
92Turricephaly (HP:0000262)1.98116664
93EEG with generalized epileptiform discharges (HP:0011198)1.98091082
94Obstructive sleep apnea (HP:0002870)1.97138914
95Agitation (HP:0000713)1.96863589
96Megalencephaly (HP:0001355)1.95920107
97Bundle branch block (HP:0011710)1.93339031
98Aplasia involving bones of the extremities (HP:0009825)1.92228854
99Aplasia involving bones of the upper limbs (HP:0009823)1.92228854
100Aplasia of the phalanges of the hand (HP:0009802)1.92228854
101Lower limb asymmetry (HP:0100559)1.92159078
102Incomplete penetrance (HP:0003829)1.91299536
103Hypsarrhythmia (HP:0002521)1.91263648
104Clonus (HP:0002169)1.90746626
105Insomnia (HP:0100785)1.90665005
106Polyphagia (HP:0002591)1.88657587
107Rigidity (HP:0002063)1.88003653
108Hypoventilation (HP:0002791)1.86842235
109Apathy (HP:0000741)1.86420803
110Horizontal nystagmus (HP:0000666)1.84641732
111Gait ataxia (HP:0002066)1.84316783
112Spinal canal stenosis (HP:0003416)1.84194100
113Inability to walk (HP:0002540)1.83810676
114Hypoplasia of the corpus callosum (HP:0002079)1.78053344
115Bilateral microphthalmos (HP:0007633)1.77526893
116Bronchomalacia (HP:0002780)1.77390429
117Psychosis (HP:0000709)1.76753710
118Spastic tetraplegia (HP:0002510)1.76475152
119Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76241119
120Iris hypopigmentation (HP:0007730)1.76045178
121Hypercortisolism (HP:0001578)1.74759424
122Gait imbalance (HP:0002141)1.72368496
123Increased circulating renin level (HP:0000848)1.70787689
124Specific learning disability (HP:0001328)1.69327094
125Fetal akinesia sequence (HP:0001989)1.64284511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.51571562
2EPHA44.38215134
3MAP3K94.05741553
4GRK52.63591428
5MAP3K42.59470668
6DAPK22.54526236
7MINK12.46472374
8PAK62.39547102
9KSR22.39243909
10PRKD32.38962344
11MARK12.31145005
12NTRK12.19064610
13NTRK22.03167537
14MAP2K41.97158280
15CAMKK11.95229265
16MAP2K71.92779089
17MAP3K121.82246151
18TYRO31.80351682
19STK381.64921115
20RIPK41.63277486
21DAPK11.56466524
22CDK51.53175548
23KSR11.53036065
24ARAF1.50490200
25TAOK11.45554485
26CDK191.39269969
27SIK21.36066474
28UHMK11.29028822
29MAP3K131.27708280
30MAP3K21.25328401
31PRKCG1.19318923
32PLK21.12633586
33PRPF4B1.11520616
34FES1.08219475
35PRKCH1.07465096
36CAMKK21.04461136
37ALK1.03219569
38CDK180.99016485
39LATS20.98252165
40CDK150.97168865
41CAMK10.96774373
42DYRK20.95401659
43CASK0.91619156
44PKN10.90223066
45CDK140.89515874
46MARK20.89376159
47TNIK0.86684774
48STK110.86337729
49CDK11A0.85161785
50MAPK130.85122152
51WNK10.82690355
52MAP3K10.82370176
53SGK2230.81977446
54SGK4940.81977446
55PINK10.81429416
56PHKG10.81108178
57PHKG20.81108178
58RET0.79618676
59PNCK0.79486294
60PAK30.79475399
61CAMK2A0.79443355
62CAMK40.78852501
63FGFR20.77549211
64NEK60.77539798
65NEK10.74678401
66RIPK10.74470801
67SGK30.74092028
68LMTK20.70905806
69GRK60.70693155
70RAF10.70263641
71SGK20.70010229
72PDK10.69546541
73LIMK10.68627734
74TNK20.68416305
75ADRBK20.66523492
76MOS0.63147169
77PDPK10.60833711
78BRAF0.59981953
79DYRK1A0.59981569
80SGK10.59215279
81MAPK120.59164014
82PTK2B0.58764508
83CDC42BPA0.56842688
84MAP4K20.55887087
85CAMK2B0.55208654
86MAP3K70.54108307
87IRAK20.54002019
88MAP3K110.52475350
89RPS6KA30.51660611
90AKT30.50777816
91CDK120.50672729
92SIK30.49931992
93CAMK2D0.49564477
94MAPK70.48969858
95MAPK100.48035008
96PDGFRA0.47322692
97ROCK20.47211334
98OXSR10.47078586
99GRK70.45742094
100CSNK1G20.44203280
101CAMK1G0.42335594
102BRSK10.41832911
103CSNK1G30.41419417
104DAPK30.40944415
105SCYL20.39744140
106WNK30.39552606
107FYN0.38728093
108PRKCZ0.38231284
109CSNK1A1L0.38116458
110ADRBK10.37882631
111BMPR20.37469907
112ERBB20.37013502
113HIPK20.35987407
114DDR20.35111160
115PRKG10.34508461
116PRKCE0.33940935
117MAP2K10.33301409
118CAMK2G0.32998691
119CSNK1E0.32686516
120PRKCA0.32510858
121CSNK1D0.31990663
122ROCK10.31438470
123MAPK80.31346568
124PRKACA0.31088339
125CSNK1A10.29528647
126GSK3B0.28692776
127TESK10.26416710

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.42603237
2Nicotine addiction_Homo sapiens_hsa050333.35693416
3Olfactory transduction_Homo sapiens_hsa047402.75012126
4GABAergic synapse_Homo sapiens_hsa047272.74233997
5Circadian entrainment_Homo sapiens_hsa047132.60584567
6Long-term potentiation_Homo sapiens_hsa047202.59061828
7Glutamatergic synapse_Homo sapiens_hsa047242.49780061
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.46442332
9Amphetamine addiction_Homo sapiens_hsa050312.45155953
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.43906783
11Morphine addiction_Homo sapiens_hsa050322.40746019
12Dopaminergic synapse_Homo sapiens_hsa047282.14865209
13Insulin secretion_Homo sapiens_hsa049112.11846267
14Salivary secretion_Homo sapiens_hsa049702.07845492
15Cholinergic synapse_Homo sapiens_hsa047251.87128505
16Cocaine addiction_Homo sapiens_hsa050301.84881759
17Gastric acid secretion_Homo sapiens_hsa049711.84004984
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80140294
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73254037
20Taste transduction_Homo sapiens_hsa047421.72758801
21Long-term depression_Homo sapiens_hsa047301.64843804
22Oxytocin signaling pathway_Homo sapiens_hsa049211.61457598
23Renin secretion_Homo sapiens_hsa049241.61373486
24Serotonergic synapse_Homo sapiens_hsa047261.61015374
25Calcium signaling pathway_Homo sapiens_hsa040201.54509613
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52941152
27GnRH signaling pathway_Homo sapiens_hsa049121.50548165
28Collecting duct acid secretion_Homo sapiens_hsa049661.43909245
29Vitamin B6 metabolism_Homo sapiens_hsa007501.39647665
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36408041
31Gap junction_Homo sapiens_hsa045401.34655390
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32689102
33cAMP signaling pathway_Homo sapiens_hsa040241.30262038
34Type II diabetes mellitus_Homo sapiens_hsa049301.25958179
35Nitrogen metabolism_Homo sapiens_hsa009101.23963098
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17745421
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14482283
38Estrogen signaling pathway_Homo sapiens_hsa049151.13055296
39Glioma_Homo sapiens_hsa052141.11523680
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03117070
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02152802
42Melanogenesis_Homo sapiens_hsa049161.01754949
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98428192
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97812714
45ErbB signaling pathway_Homo sapiens_hsa040120.97309962
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.96780417
47Vibrio cholerae infection_Homo sapiens_hsa051100.96510138
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.95729827
49Cardiac muscle contraction_Homo sapiens_hsa042600.93733229
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88634592
51Axon guidance_Homo sapiens_hsa043600.88369374
52Dorso-ventral axis formation_Homo sapiens_hsa043200.87818440
53Oocyte meiosis_Homo sapiens_hsa041140.84315342
54Dilated cardiomyopathy_Homo sapiens_hsa054140.82343833
55Thyroid hormone synthesis_Homo sapiens_hsa049180.78596559
56Pancreatic secretion_Homo sapiens_hsa049720.77550308
57mTOR signaling pathway_Homo sapiens_hsa041500.75302240
58Choline metabolism in cancer_Homo sapiens_hsa052310.73135306
59MAPK signaling pathway_Homo sapiens_hsa040100.72484322
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.71702251
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69135095
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68563955
63Type I diabetes mellitus_Homo sapiens_hsa049400.67960690
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67431663
65VEGF signaling pathway_Homo sapiens_hsa043700.67407799
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66891828
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65192989
68Rap1 signaling pathway_Homo sapiens_hsa040150.61685970
69Inositol phosphate metabolism_Homo sapiens_hsa005620.60262611
70Alzheimers disease_Homo sapiens_hsa050100.59795657
71Ras signaling pathway_Homo sapiens_hsa040140.58575146
72Glucagon signaling pathway_Homo sapiens_hsa049220.57098325
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55564837
74Endocytosis_Homo sapiens_hsa041440.53955751
75Phototransduction_Homo sapiens_hsa047440.53268820
76Non-small cell lung cancer_Homo sapiens_hsa052230.53167782
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.53043065
78Bile secretion_Homo sapiens_hsa049760.52600256
79Hippo signaling pathway_Homo sapiens_hsa043900.52378617
80Alcoholism_Homo sapiens_hsa050340.50716555
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49447434
82Prion diseases_Homo sapiens_hsa050200.49418940
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47892233
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46010535
85Endometrial cancer_Homo sapiens_hsa052130.41404027
86Hedgehog signaling pathway_Homo sapiens_hsa043400.41263230
87Insulin signaling pathway_Homo sapiens_hsa049100.41030012
88Ovarian steroidogenesis_Homo sapiens_hsa049130.40984285
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40887971
90Renal cell carcinoma_Homo sapiens_hsa052110.40479722
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40108746
92Arginine and proline metabolism_Homo sapiens_hsa003300.38144380
93Oxidative phosphorylation_Homo sapiens_hsa001900.38086030
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37218733
95Wnt signaling pathway_Homo sapiens_hsa043100.37079641
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36295051
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35590366
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35552783
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35463765
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35054994
101Chemokine signaling pathway_Homo sapiens_hsa040620.33918284
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33534938
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33306161
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32718768
105Circadian rhythm_Homo sapiens_hsa047100.32011782
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31675033
107African trypanosomiasis_Homo sapiens_hsa051430.31130739
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.30527452
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.29704756
110Tight junction_Homo sapiens_hsa045300.28447575
111Parkinsons disease_Homo sapiens_hsa050120.25573628
112Basal cell carcinoma_Homo sapiens_hsa052170.24442572
113AMPK signaling pathway_Homo sapiens_hsa041520.23623169
114beta-Alanine metabolism_Homo sapiens_hsa004100.22163280
115Regulation of autophagy_Homo sapiens_hsa041400.20762750
116Histidine metabolism_Homo sapiens_hsa003400.19893586

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