PIAS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.50829047
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.50829047
3neural tube formation (GO:0001841)4.50840625
4cellular response to interleukin-15 (GO:0071350)3.98936468
5regulation of B cell receptor signaling pathway (GO:0050855)3.97556588
6limb bud formation (GO:0060174)3.86817703
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.78658399
8prostate gland growth (GO:0060736)3.68364725
9immunoglobulin mediated immune response (GO:0016064)3.64736847
10DNA integration (GO:0015074)3.59122884
11interferon-gamma production (GO:0032609)3.57901720
12response to pheromone (GO:0019236)3.57554680
13establishment of protein localization to Golgi (GO:0072600)3.53305744
14positive regulation of gamma-delta T cell activation (GO:0046645)3.46528257
15sequestering of actin monomers (GO:0042989)3.41719676
16protein targeting to Golgi (GO:0000042)3.37919238
17mast cell activation (GO:0045576)3.36379306
18negative regulation of mast cell activation (GO:0033004)3.35778381
19chaperone mediated protein folding requiring cofactor (GO:0051085)3.26114417
20histone H3-K4 trimethylation (GO:0080182)3.26103447
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.23875582
22retrograde transport, vesicle recycling within Golgi (GO:0000301)3.23133918
23neutrophil activation involved in immune response (GO:0002283)3.19516766
24negative regulation of alpha-beta T cell differentiation (GO:0046639)3.18311938
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.17826552
26response to interleukin-15 (GO:0070672)3.16852300
27regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.14711180
28regulation of mast cell activation (GO:0033003)3.13703624
29protein localization to cilium (GO:0061512)3.12199510
30centriole replication (GO:0007099)3.11050949
31negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.10693061
32negative regulation of translation, ncRNA-mediated (GO:0040033)3.10693061
33regulation of translation, ncRNA-mediated (GO:0045974)3.10693061
34prenylation (GO:0097354)3.08819597
35protein prenylation (GO:0018342)3.08819597
36positive regulation of granulocyte differentiation (GO:0030854)3.05436464
37regulation of memory T cell differentiation (GO:0043380)3.02162482
38megakaryocyte development (GO:0035855)3.00604586
39response to peptidoglycan (GO:0032494)2.99983820
40negative regulation of neurotransmitter transport (GO:0051589)2.99682725
41regulation of protein glycosylation (GO:0060049)2.99212715
42negative regulation of protein oligomerization (GO:0032460)2.99110415
43somite development (GO:0061053)2.96680693
44leukocyte aggregation (GO:0070486)2.92839507
45myeloid dendritic cell activation (GO:0001773)2.89836646
46histone mRNA catabolic process (GO:0071044)2.89610749
47positive regulation of mast cell activation (GO:0033005)2.89305677
48phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.88474007
49positive regulation of amino acid transport (GO:0051957)2.85697229
50peptidyl-lysine trimethylation (GO:0018023)2.84885563
51B cell proliferation (GO:0042100)2.84291832
52respiratory chain complex IV assembly (GO:0008535)2.82222751
53activated T cell proliferation (GO:0050798)2.77712442
54B cell receptor signaling pathway (GO:0050853)2.77269722
55regulation of female gonad development (GO:2000194)2.76838199
56negative regulation of neurotransmitter secretion (GO:0046929)2.76120767
57inositol phosphate catabolic process (GO:0071545)2.74838894
58mature B cell differentiation involved in immune response (GO:0002313)2.73381905
59lymphoid progenitor cell differentiation (GO:0002320)2.73140690
60positive regulation of oligodendrocyte differentiation (GO:0048714)2.72227979
61pancreas development (GO:0031016)2.71679045
62negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.71102143
63histamine secretion (GO:0001821)2.71007312
64regulation of meiosis I (GO:0060631)2.70167258
65RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69502337
66B cell mediated immunity (GO:0019724)2.69403822
67polyketide metabolic process (GO:0030638)2.68919307
68doxorubicin metabolic process (GO:0044598)2.68919307
69daunorubicin metabolic process (GO:0044597)2.68919307
70positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.68763464
71cellular response to exogenous dsRNA (GO:0071360)2.68538159
72positive regulation by symbiont of host defense response (GO:0052509)2.67901630
73modulation by symbiont of host defense response (GO:0052031)2.67901630
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.67901630
75modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.67901630
76positive regulation by organism of defense response of other organism involved in symbiotic interact2.67901630
77modulation by symbiont of host immune response (GO:0052553)2.67901630
78negative regulation of T cell mediated immunity (GO:0002710)2.66570337
79negative regulation of cAMP-mediated signaling (GO:0043951)2.65806501
80intra-Golgi vesicle-mediated transport (GO:0006891)2.65543401
81regulation of RIG-I signaling pathway (GO:0039535)2.65462091
82Golgi to endosome transport (GO:0006895)2.64282984
83regulation of cilium movement (GO:0003352)2.64166821
84piRNA metabolic process (GO:0034587)2.64087240
85positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.63019523
86regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.63019523
87positive regulation of histone H3-K4 methylation (GO:0051571)2.63001686
88positive regulation of antigen processing and presentation (GO:0002579)2.62117235
89establishment of chromosome localization (GO:0051303)2.61578257
90regulation of glucokinase activity (GO:0033131)2.58635504
91regulation of hexokinase activity (GO:1903299)2.58635504
92microtubule anchoring (GO:0034453)2.58556781
93lymph node development (GO:0048535)2.58062394
94cilium or flagellum-dependent cell motility (GO:0001539)2.57500608
95positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.57260695
96regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.57260695
97mature B cell differentiation (GO:0002335)2.56728348
98mast cell activation involved in immune response (GO:0002279)2.56661229
99mast cell degranulation (GO:0043303)2.56661229
100intraciliary transport (GO:0042073)2.55221101
101negative regulation of phagocytosis (GO:0050765)2.55021532
102positive regulation of alpha-beta T cell proliferation (GO:0046641)2.54376935
103regulation of mast cell degranulation (GO:0043304)2.53199827
104epithelial cilium movement (GO:0003351)2.53006836
105regulation of B cell differentiation (GO:0045577)2.52855458
106negative T cell selection (GO:0043383)2.52490226
107kidney morphogenesis (GO:0060993)2.52385560
108* interferon-gamma-mediated signaling pathway (GO:0060333)2.51799208
109regulation of alpha-beta T cell proliferation (GO:0046640)2.51731090
110photoreceptor cell maintenance (GO:0045494)2.50950880
111positive regulation of interferon-alpha production (GO:0032727)2.50860888
112T cell migration (GO:0072678)2.50638726
113dopamine transport (GO:0015872)2.50492113
114presynaptic membrane assembly (GO:0097105)2.50120697
115cytochrome complex assembly (GO:0017004)2.49948212
116attachment of spindle microtubules to kinetochore (GO:0008608)2.49728886
117cilium morphogenesis (GO:0060271)2.49206029
118meiotic chromosome segregation (GO:0045132)2.48880246
119regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.48860496
120regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.47739212
121neutrophil mediated immunity (GO:0002446)2.47706702
122detection of other organism (GO:0098543)2.47685932
123positive regulation of mRNA processing (GO:0050685)2.46438447
124regulation of mast cell activation involved in immune response (GO:0033006)2.46273412
125RNA destabilization (GO:0050779)2.45199993
126retinal ganglion cell axon guidance (GO:0031290)2.44826272
127regulation of T cell mediated cytotoxicity (GO:0001914)2.44388048
128hepatocyte apoptotic process (GO:0097284)2.43691859
129type I interferon signaling pathway (GO:0060337)2.43430333
130cellular response to type I interferon (GO:0071357)2.43430333
131positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42496093
132protein localization to Golgi apparatus (GO:0034067)2.42220747
133defense response to protozoan (GO:0042832)2.41693186
134negative thymic T cell selection (GO:0045060)2.41502716
135positive regulation of B cell differentiation (GO:0045579)2.41439957
136negative regulation of alpha-beta T cell activation (GO:0046636)2.40408895
137cilium organization (GO:0044782)2.40137371
138inositol phosphate dephosphorylation (GO:0046855)2.39943706
139phosphorylated carbohydrate dephosphorylation (GO:0046838)2.39943706
140mitotic sister chromatid cohesion (GO:0007064)2.39896406
141myeloid dendritic cell differentiation (GO:0043011)2.39600896
142antigen processing and presentation of endogenous antigen (GO:0019883)2.39537134
143DNA synthesis involved in DNA repair (GO:0000731)2.39451435
144protein K48-linked ubiquitination (GO:0070936)2.39411814
145respiratory burst (GO:0045730)2.39207783
146response to type I interferon (GO:0034340)2.39013839
147regulation of T cell receptor signaling pathway (GO:0050856)2.38867414
148positive regulation of mRNA catabolic process (GO:0061014)2.38277685
149interkinetic nuclear migration (GO:0022027)2.38170087
150synapsis (GO:0007129)2.37800528
151cilium assembly (GO:0042384)2.37610796
152neutrophil activation (GO:0042119)2.37395867
153retinal cone cell development (GO:0046549)2.37116299
154positive regulation of interferon-gamma production (GO:0032729)2.36506122
155negative regulation of execution phase of apoptosis (GO:1900118)2.36459857
156mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.36075580
157positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.36075580
158anterograde synaptic vesicle transport (GO:0048490)2.35885616
159nonmotile primary cilium assembly (GO:0035058)2.35792852
160DNA double-strand break processing (GO:0000729)2.35487113
161regulation of granulocyte differentiation (GO:0030852)2.35223382
162spinal cord motor neuron differentiation (GO:0021522)2.34934377
163positive regulation of mRNA metabolic process (GO:1903313)2.34715244
164regulation of interferon-alpha production (GO:0032647)2.34128468
165regulation of dendritic cell antigen processing and presentation (GO:0002604)2.33101572
166I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.32735041
167myeloid cell activation involved in immune response (GO:0002275)2.32623933
168dendritic cell migration (GO:0036336)2.32623014
169cullin deneddylation (GO:0010388)2.31818527
170embryonic digestive tract morphogenesis (GO:0048557)2.31783174
171negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.30299307
172negative regulation of T-helper cell differentiation (GO:0045623)2.30299307
173detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.29749179
174hindbrain development (GO:0030902)2.29144505
175histone H2A acetylation (GO:0043968)2.28969287
176protein K11-linked deubiquitination (GO:0035871)2.28704815
177regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.28550176
178keratinocyte development (GO:0003334)2.28248788
179necroptotic process (GO:0070266)2.27244846
180positive regulation of macrophage differentiation (GO:0045651)2.27145907
181brain morphogenesis (GO:0048854)2.27057565
182regulation of mitotic spindle checkpoint (GO:1903504)2.26599626
183regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.26599626
184G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.24825731
185positive regulation of defense response to virus by host (GO:0002230)2.24493656
186microglial cell activation (GO:0001774)2.24478472
187dentate gyrus development (GO:0021542)2.22656197
188negative regulation of viral genome replication (GO:0045071)2.22128278
189myeloid leukocyte activation (GO:0002274)2.22021255
190nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.21685754
191regulation of antigen processing and presentation (GO:0002577)2.21375574

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.19921013
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.16304510
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.08619609
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.83866785
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.82977296
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.10068863
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.75759476
8E2F7_22180533_ChIP-Seq_HELA_Human2.74419959
9* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.64141520
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.60463214
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.56094678
12ZNF274_21170338_ChIP-Seq_K562_Hela2.54456966
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.53202652
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.52009793
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48754979
16TAF15_26573619_Chip-Seq_HEK293_Human2.47366735
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.32344316
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.31866889
19RUNX_20019798_ChIP-Seq_JUKART_Human2.19782943
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17235900
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17208418
22* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.09032780
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08964290
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08355478
25SCL_19346495_ChIP-Seq_HPC-7_Human2.05450008
26VDR_22108803_ChIP-Seq_LS180_Human2.00376044
27* SPI1_23547873_ChIP-Seq_NB4_Human1.99534673
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98441030
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92260968
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91956765
31* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90716780
32MYB_26560356_Chip-Seq_TH2_Human1.90102154
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87958393
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87796660
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79714353
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78702242
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76859600
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75402514
39ER_23166858_ChIP-Seq_MCF-7_Human1.73910008
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66676478
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65250689
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64744754
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64497099
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.64046402
45SMAD4_21799915_ChIP-Seq_A2780_Human1.63763492
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63653622
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.61816670
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61782976
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61672938
50* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60588876
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59042502
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.58425801
53* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57537874
54STAT3_23295773_ChIP-Seq_U87_Human1.57256401
55BCAT_22108803_ChIP-Seq_LS180_Human1.51810981
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.50910509
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48091994
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47996753
59CBP_20019798_ChIP-Seq_JUKART_Human1.47996753
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46213077
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.44588189
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44394795
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44394795
64AR_25329375_ChIP-Seq_VCAP_Human1.43140419
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42960043
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40711534
67* TCF4_23295773_ChIP-Seq_U87_Human1.40268758
68MYB_26560356_Chip-Seq_TH1_Human1.39348749
69IRF1_19129219_ChIP-ChIP_H3396_Human1.36674988
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36426838
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35593592
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34329837
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.33692831
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33009452
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31847420
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28980174
77GATA3_26560356_Chip-Seq_TH2_Human1.28780127
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27883004
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26793538
80* SOX2_19829295_ChIP-Seq_ESCs_Human1.26224588
81* NANOG_19829295_ChIP-Seq_ESCs_Human1.26224588
82TCF4_22108803_ChIP-Seq_LS180_Human1.25591106
83* GATA3_27048872_Chip-Seq_THYMUS_Human1.25561361
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25329889
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.25136431
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.24430285
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23813315
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23633399
89FUS_26573619_Chip-Seq_HEK293_Human1.21769671
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21226391
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20877125
92IGF1R_20145208_ChIP-Seq_DFB_Human1.20320852
93* RUNX2_22187159_ChIP-Seq_PCA_Human1.19008091
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18766450
95FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17059568
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16940810
97* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16392355
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14800621
99GBX2_23144817_ChIP-Seq_PC3_Human1.14707306
100SALL4_22934838_ChIP-ChIP_CD34+_Human1.14636272
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.14586237
102STAT3_18555785_Chip-Seq_ESCs_Mouse1.14460683
103TP63_19390658_ChIP-ChIP_HaCaT_Human1.14274914
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13806908
105PU_27001747_Chip-Seq_BMDM_Mouse1.13483695
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13430057
107ELK1_19687146_ChIP-ChIP_HELA_Human1.13315907
108RUNX1_22412390_ChIP-Seq_EML_Mouse1.12354641
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11841629
110SPI1_23127762_ChIP-Seq_K562_Human1.11475355
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09466095
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09212464
113SRF_21415370_ChIP-Seq_HL-1_Mouse1.08384808
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.08342540
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08283384
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.08088117
117OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07466090
118ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06244850
119P300_18555785_Chip-Seq_ESCs_Mouse1.05986319
120GATA1_22025678_ChIP-Seq_K562_Human1.05548317
121VDR_23849224_ChIP-Seq_CD4+_Human1.05397956
122* EWS_26573619_Chip-Seq_HEK293_Human1.05264277
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05192179
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04492951
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04046797
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03909637
127RNF2_27304074_Chip-Seq_NSC_Mouse1.03778174
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03609126
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03604463
130TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03135160
131EZH2_27294783_Chip-Seq_NPCs_Mouse1.02863701
132SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02455924
133FOXM1_23109430_ChIP-Seq_U2OS_Human1.02311589
134TP53_22573176_ChIP-Seq_HFKS_Human1.01781184
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01710030
136* TAL1_26923725_Chip-Seq_HPCs_Mouse1.01061699
137CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00382134
138FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00255309
139RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99067318
140EST1_17652178_ChIP-ChIP_JURKAT_Human0.98684837
141P53_22387025_ChIP-Seq_ESCs_Mouse0.98250098
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.97874450
143* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97851952
144MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96593263
145SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96578110
146EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96547295
147P300_19829295_ChIP-Seq_ESCs_Human0.95799983
148NMYC_18555785_Chip-Seq_ESCs_Mouse0.94887423
149SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92779449
150NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92747141
151CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91870548
152EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90925624
153HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90325818
154FOXP3_21729870_ChIP-Seq_TREG_Human0.90197656
155OCT4_18555785_Chip-Seq_ESCs_Mouse0.89169718
156CIITA_25753668_ChIP-Seq_RAJI_Human0.88751905
157GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88297930
158CMYC_18555785_Chip-Seq_ESCs_Mouse0.87575653
159PU1_27457419_Chip-Seq_LIVER_Mouse0.87424783
160* VDR_24787735_ChIP-Seq_THP-1_Human0.87007596
161GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86524317

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.37047574
2MP0001835_abnormal_antigen_presentation4.25782346
3MP0005671_abnormal_response_to3.23221247
4MP0003195_calcinosis2.83901423
5MP0003763_abnormal_thymus_physiology2.79181384
6* MP0009785_altered_susceptibility_to2.78124154
7MP0002148_abnormal_hypersensitivity_rea2.65940937
8MP0008877_abnormal_DNA_methylation2.56248884
9MP0003880_abnormal_central_pattern2.49182890
10MP0001800_abnormal_humoral_immune2.48168974
11MP0005000_abnormal_immune_tolerance2.46152092
12MP0002452_abnormal_antigen_presenting2.44216246
13MP0003724_increased_susceptibility_to2.40757711
14MP0003787_abnormal_imprinting2.39772311
15MP0002419_abnormal_innate_immunity2.35670316
16MP0002420_abnormal_adaptive_immunity2.31257210
17MP0001819_abnormal_immune_cell2.30666706
18MP0005387_immune_system_phenotype2.29935001
19MP0001790_abnormal_immune_system2.29935001
20MP0002723_abnormal_immune_serum2.27644077
21MP0002396_abnormal_hematopoietic_system2.16876894
22MP0008007_abnormal_cellular_replicative2.15770547
23* MP0005025_abnormal_response_to2.14118039
24MP0002398_abnormal_bone_marrow2.13845848
25MP0009333_abnormal_splenocyte_physiolog2.05773509
26MP0002234_abnormal_pharynx_morphology1.97599878
27MP0010094_abnormal_chromosome_stability1.94720559
28MP0000685_abnormal_immune_system1.92101480
29MP0003693_abnormal_embryo_hatching1.91443918
30MP0004808_abnormal_hematopoietic_stem1.91079831
31MP0002006_tumorigenesis1.89391870
32MP0003183_abnormal_peptide_metabolism1.88467072
33MP0005646_abnormal_pituitary_gland1.84466498
34MP0000716_abnormal_immune_system1.83543633
35MP0003436_decreased_susceptibility_to1.83196699
36MP0008058_abnormal_DNA_repair1.78831487
37MP0005464_abnormal_platelet_physiology1.76911215
38MP0000383_abnormal_hair_follicle1.76106367
39MP0000689_abnormal_spleen_morphology1.72181314
40MP0005645_abnormal_hypothalamus_physiol1.71851672
41MP0002405_respiratory_system_inflammati1.70288650
42MP0000015_abnormal_ear_pigmentation1.69614206
43MP0001853_heart_inflammation1.66548246
44MP0008995_early_reproductive_senescence1.64151490
45MP0000465_gastrointestinal_hemorrhage1.59732248
46MP0002722_abnormal_immune_system1.58646386
47MP0000427_abnormal_hair_cycle1.58057250
48MP0003943_abnormal_hepatobiliary_system1.57056572
49MP0002429_abnormal_blood_cell1.56163105
50MP0003283_abnormal_digestive_organ1.56036718
51MP0001529_abnormal_vocalization1.51626606
52MP0006054_spinal_hemorrhage1.49072964
53MP0001188_hyperpigmentation1.48656106
54MP0000703_abnormal_thymus_morphology1.46326042
55MP0005174_abnormal_tail_pigmentation1.46060703
56MP0003890_abnormal_embryonic-extraembry1.45798003
57MP0000516_abnormal_urinary_system1.45538722
58MP0005367_renal/urinary_system_phenotyp1.45538722
59MP0006292_abnormal_olfactory_placode1.45457012
60MP0002166_altered_tumor_susceptibility1.44623364
61MP0010155_abnormal_intestine_physiology1.44581123
62MP0005075_abnormal_melanosome_morpholog1.43807426
63MP0000569_abnormal_digit_pigmentation1.41355469
64MP0001986_abnormal_taste_sensitivity1.41052942
65MP0005397_hematopoietic_system_phenotyp1.41001304
66MP0001545_abnormal_hematopoietic_system1.41001304
67MP0005253_abnormal_eye_physiology1.38972046
68MP0010678_abnormal_skin_adnexa1.38342303
69MP0000858_altered_metastatic_potential1.37541843
70MP0005310_abnormal_salivary_gland1.36594848
71MP0002928_abnormal_bile_duct1.35358521
72MP0002751_abnormal_autonomic_nervous1.34067507
73MP0004782_abnormal_surfactant_physiolog1.33341715
74* MP0001845_abnormal_inflammatory_respons1.29366756
75MP0003077_abnormal_cell_cycle1.29322907
76MP0003122_maternal_imprinting1.28125713
77MP0008057_abnormal_DNA_replication1.22236211
78MP0002876_abnormal_thyroid_physiology1.19505653
79MP0002822_catalepsy1.18187616
80MP0001119_abnormal_female_reproductive1.18130706
81MP0009764_decreased_sensitivity_to1.17441970
82MP0003656_abnormal_erythrocyte_physiolo1.16693718
83MP0000490_abnormal_crypts_of1.15979795
84MP0000631_abnormal_neuroendocrine_gland1.15347517
85MP0004142_abnormal_muscle_tone1.13383885
86MP0003448_altered_tumor_morphology1.13022216
87MP0010386_abnormal_urinary_bladder1.12792038
88MP0002277_abnormal_respiratory_mucosa1.11276288
89MP0004924_abnormal_behavior1.10320771
90MP0005386_behavior/neurological_phenoty1.10320771
91MP0009697_abnormal_copulation1.09230262
92MP0002095_abnormal_skin_pigmentation1.07546879
93MP0002837_dystrophic_cardiac_calcinosis1.07077951
94MP0005084_abnormal_gallbladder_morpholo1.06072267
95MP0002638_abnormal_pupillary_reflex1.01784425
96MP0001486_abnormal_startle_reflex1.00375374
97MP0001929_abnormal_gametogenesis0.98461854
98MP0004215_abnormal_myocardial_fiber0.97462448
99MP0006276_abnormal_autonomic_nervous0.95736791
100MP0003111_abnormal_nucleus_morphology0.95142991
101MP0002009_preneoplasia0.95014635
102MP0001324_abnormal_eye_pigmentation0.94072555
103MP0001533_abnormal_skeleton_physiology0.94055973
104MP0008260_abnormal_autophagy0.92392619
105MP0006082_CNS_inflammation0.91637919
106MP0003718_maternal_effect0.89970561
107MP0004133_heterotaxia0.89506902
108MP0002019_abnormal_tumor_incidence0.89336847
109MP0003121_genomic_imprinting0.89143466
110MP0008961_abnormal_basal_metabolism0.89122680
111MP0004510_myositis0.87035246
112MP0002933_joint_inflammation0.86730678
113MP0002210_abnormal_sex_determination0.84692945
114MP0004484_altered_response_of0.84381151
115MP0009745_abnormal_behavioral_response0.84367989
116MP0006072_abnormal_retinal_apoptosis0.83754726
117MP0000778_abnormal_nervous_system0.83261930
118MP0001873_stomach_inflammation0.82545450
119MP0001293_anophthalmia0.81548947
120MP0008872_abnormal_physiological_respon0.81440602
121MP0000343_altered_response_to0.80540024
122MP0005379_endocrine/exocrine_gland_phen0.79735087
123MP0008789_abnormal_olfactory_epithelium0.78322755
124MP0003567_abnormal_fetal_cardiomyocyte0.78140607
125MP0005171_absent_coat_pigmentation0.77722806
126MP0005409_darkened_coat_color0.77429358
127MP0005410_abnormal_fertilization0.77326949
128MP0005248_abnormal_Harderian_gland0.76197756
129MP0002909_abnormal_adrenal_gland0.75933720
130MP0003866_abnormal_defecation0.75871347
131MP0002132_abnormal_respiratory_system0.75768871
132MP0002938_white_spotting0.75472280
133MP0008469_abnormal_protein_level0.75278202
134MP0000647_abnormal_sebaceous_gland0.73780721
135MP0001919_abnormal_reproductive_system0.73610072
136MP0002272_abnormal_nervous_system0.72869359
137MP0002735_abnormal_chemical_nociception0.72033639
138MP0001968_abnormal_touch/_nociception0.71959494
139MP0000372_irregular_coat_pigmentation0.71886009
140MP0005551_abnormal_eye_electrophysiolog0.71450304
141MP0001984_abnormal_olfaction0.71369820
142MP0001915_intracranial_hemorrhage0.71038017
143MP0003698_abnormal_male_reproductive0.69062758
144MP0001501_abnormal_sleep_pattern0.69017397
145MP0002693_abnormal_pancreas_physiology0.68964451
146MP0004883_abnormal_blood_vessel0.68784698
147MP0003172_abnormal_lysosome_physiology0.68091753
148MP0004947_skin_inflammation0.67588021
149MP0003252_abnormal_bile_duct0.67294969
150MP0001764_abnormal_homeostasis0.67221568
151MP0005058_abnormal_lysosome_morphology0.66781637
152MP0002998_abnormal_bone_remodeling0.66202995
153MP0003786_premature_aging0.65330084
154MP0000653_abnormal_sex_gland0.65146355
155MP0003828_pulmonary_edema0.64989333
156MP0002163_abnormal_gland_morphology0.64241072

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.30205709
2Abnormal hair whorl (HP:0010721)4.13479659
3Thyroiditis (HP:0100646)3.99026412
4Recurrent bacterial skin infections (HP:0005406)3.85237287
5Severe combined immunodeficiency (HP:0004430)3.74223253
6Myositis (HP:0100614)3.62245231
7Optic neuritis (HP:0100653)3.57307368
8Retrobulbar optic neuritis (HP:0100654)3.57307368
9Combined immunodeficiency (HP:0005387)3.42056753
10Pancreatic cysts (HP:0001737)3.30803534
11Mediastinal lymphadenopathy (HP:0100721)3.28056837
12Chromsome breakage (HP:0040012)3.16289571
13Intestinal atresia (HP:0011100)3.10505674
14Orchitis (HP:0100796)3.07980549
15Eczematoid dermatitis (HP:0000976)3.05834290
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98007922
17T lymphocytopenia (HP:0005403)2.95105835
18Neoplasm of the adrenal cortex (HP:0100641)2.93920408
19Volvulus (HP:0002580)2.91367686
20Abnormality of T cell number (HP:0011839)2.87861457
21Agnosia (HP:0010524)2.85751586
22Aplastic anemia (HP:0001915)2.83973935
23Papillary thyroid carcinoma (HP:0002895)2.78732605
24Abnormality of the prostate (HP:0008775)2.77797002
25Elevated erythrocyte sedimentation rate (HP:0003565)2.76566049
26Abnormality of eosinophils (HP:0001879)2.75252112
27Clubbing of toes (HP:0100760)2.73255922
28Abnormality of the fingertips (HP:0001211)2.72769745
29Oligodactyly (hands) (HP:0001180)2.67994741
30Widely spaced teeth (HP:0000687)2.67228809
31Leukocytosis (HP:0001974)2.64361348
32Agammaglobulinemia (HP:0004432)2.61464868
33Congenital primary aphakia (HP:0007707)2.59659436
34Fair hair (HP:0002286)2.58458300
35Recurrent fungal infections (HP:0002841)2.56993428
36Abnormality of midbrain morphology (HP:0002418)2.56311069
37Molar tooth sign on MRI (HP:0002419)2.56311069
38Gait imbalance (HP:0002141)2.55936623
39Recurrent bronchitis (HP:0002837)2.55724893
40Recurrent viral infections (HP:0004429)2.54616921
41Keratoconjunctivitis sicca (HP:0001097)2.53868920
42Thrombocytosis (HP:0001894)2.53768908
43Prostate neoplasm (HP:0100787)2.52584665
44Aqueductal stenosis (HP:0002410)2.48683688
45Stomach cancer (HP:0012126)2.48300021
46Abnormality of the renal cortex (HP:0011035)2.45278820
47Abnormality of chromosome stability (HP:0003220)2.45084447
48Tubulointerstitial nephritis (HP:0001970)2.43886299
49Meningitis (HP:0001287)2.43140758
50Acute myeloid leukemia (HP:0004808)2.38811228
51Renal cortical cysts (HP:0000803)2.34475018
52Type I transferrin isoform profile (HP:0003642)2.32358728
53Obstructive lung disease (HP:0006536)2.31429963
54Chronic obstructive pulmonary disease (HP:0006510)2.31429963
55IgM deficiency (HP:0002850)2.30085389
56Nephronophthisis (HP:0000090)2.27997294
57Panhypogammaglobulinemia (HP:0003139)2.27018180
58Recurrent skin infections (HP:0001581)2.26526119
59Keratoconjunctivitis (HP:0001096)2.26377075
60Abnormality of the renal medulla (HP:0100957)2.25743109
61Pulmonary fibrosis (HP:0002206)2.24330208
62Genital tract atresia (HP:0001827)2.24295175
63Pulmonary infiltrates (HP:0002113)2.24126164
64Thyroid carcinoma (HP:0002890)2.23364018
65Autoimmune thrombocytopenia (HP:0001973)2.22273217
66Progressive inability to walk (HP:0002505)2.21664178
67Abnormal rod and cone electroretinograms (HP:0008323)2.20565789
68Myelodysplasia (HP:0002863)2.19698427
69Degeneration of anterior horn cells (HP:0002398)2.18543523
70Abnormality of the anterior horn cell (HP:0006802)2.18543523
71Abnormality of T cells (HP:0002843)2.18185086
72Hypochromic microcytic anemia (HP:0004840)2.18016692
73Petechiae (HP:0000967)2.17828696
74True hermaphroditism (HP:0010459)2.17698782
75Bronchitis (HP:0012387)2.17504430
76Medial flaring of the eyebrow (HP:0010747)2.16557966
77IgG deficiency (HP:0004315)2.14176837
78Encephalitis (HP:0002383)2.12416577
79Abnormality of the labia minora (HP:0012880)2.11548844
80Abnormality of B cell number (HP:0010975)2.09294027
81B lymphocytopenia (HP:0010976)2.09294027
82Hyperventilation (HP:0002883)2.08612352
83Vasculitis (HP:0002633)2.08256990
84Lymphopenia (HP:0001888)2.08092489
85Chronic hepatic failure (HP:0100626)2.06756386
86Aplasia/Hypoplasia of the uvula (HP:0010293)2.06359714
87Gaze-evoked nystagmus (HP:0000640)2.04379292
88Vaginal atresia (HP:0000148)2.04338163
89Poor coordination (HP:0002370)2.02663644
90Recurrent gram-negative bacterial infections (HP:0005420)2.02258809
91Abnormality of the preputium (HP:0100587)2.02016663
92Congenital stationary night blindness (HP:0007642)2.00165737
93Type 2 muscle fiber atrophy (HP:0003554)2.00025801
94White forelock (HP:0002211)1.99609122
95Meckel diverticulum (HP:0002245)1.99410532
96Arterial thrombosis (HP:0004420)1.99320849
97Recurrent cutaneous fungal infections (HP:0011370)1.98784185
98Chronic mucocutaneous candidiasis (HP:0002728)1.98784185
99Lymphoma (HP:0002665)1.98427217
100Eosinophilia (HP:0001880)1.97951076
101Patchy hypopigmentation of hair (HP:0011365)1.97798293
102Chronic otitis media (HP:0000389)1.95735909
103Recurrent pneumonia (HP:0006532)1.95548319
104Abolished electroretinogram (ERG) (HP:0000550)1.95294581
105Cellulitis (HP:0100658)1.94845283
106Abnormal spermatogenesis (HP:0008669)1.94126582
107Pancreatic fibrosis (HP:0100732)1.93241348
108Growth hormone deficiency (HP:0000824)1.91661737
109Osteomyelitis (HP:0002754)1.91600069
110Nephrogenic diabetes insipidus (HP:0009806)1.90878072
111Attenuation of retinal blood vessels (HP:0007843)1.90505850
112Abnormality of cells of the lymphoid lineage (HP:0012140)1.89930456
113Abnormality of the ileum (HP:0001549)1.89033248
114Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87973131
115Abnormality of the columella (HP:0009929)1.86611965
116Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.86532732
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.86347814
118Sepsis (HP:0100806)1.86277551
119Hip dysplasia (HP:0001385)1.86077883
120Febrile seizures (HP:0002373)1.85393431
121Generalized hypopigmentation of hair (HP:0011358)1.85385231
122Stomatitis (HP:0010280)1.85306098
123Congenital hepatic fibrosis (HP:0002612)1.83820109
124Postaxial hand polydactyly (HP:0001162)1.83164651
125Hypothermia (HP:0002045)1.82985416
126Neoplasm of the adrenal gland (HP:0100631)1.82085749
127Abnormality of incisor morphology (HP:0011063)1.81228136
128Keratitis (HP:0000491)1.81198551
129Ectopic kidney (HP:0000086)1.81040214
130Excessive salivation (HP:0003781)1.80973988
131Drooling (HP:0002307)1.80968128
132Birth length less than 3rd percentile (HP:0003561)1.80824508
133Prolonged bleeding time (HP:0003010)1.79062694
134Bone marrow hypocellularity (HP:0005528)1.78687802
135Abnormality of macrophages (HP:0004311)1.78441401
136Deep philtrum (HP:0002002)1.78045725
137Postaxial foot polydactyly (HP:0001830)1.78033591
138Dynein arm defect of respiratory motile cilia (HP:0012255)1.77576070
139Absent/shortened dynein arms (HP:0200106)1.77576070
140Dyschromatopsia (HP:0007641)1.77387694
141Absent speech (HP:0001344)1.77172258
142Pendular nystagmus (HP:0012043)1.76173269
143Chronic diarrhea (HP:0002028)1.75797380
144Abnormality of endocrine pancreas physiology (HP:0012093)1.75203914
145Abnormality of the pancreatic islet cells (HP:0006476)1.75203914
146Tented upper lip vermilion (HP:0010804)1.72750083
147Pancreatic islet-cell hyperplasia (HP:0004510)1.72561620
148Broad-based gait (HP:0002136)1.69941702
149Abnormality of the duodenum (HP:0002246)1.69636117
150Specific learning disability (HP:0001328)1.69619733
151Aplasia/Hypoplasia of the tibia (HP:0005772)1.69182515
152Astigmatism (HP:0000483)1.67772056
153Inability to walk (HP:0002540)1.67617072
154Chronic sinusitis (HP:0011109)1.67475038
155Progressive cerebellar ataxia (HP:0002073)1.65271462
156Tubulointerstitial abnormality (HP:0001969)1.64874883
157Abnormality of vitamin B metabolism (HP:0004340)1.62947619
158Sloping forehead (HP:0000340)1.62680796
159Cystic liver disease (HP:0006706)1.61929941
160Abnormality of chromosome segregation (HP:0002916)1.60138185
161Thyroid-stimulating hormone excess (HP:0002925)1.59507947
162Gonadotropin excess (HP:0000837)1.59492563
163Abnormal delayed hypersensitivity skin test (HP:0002963)1.58904991
164Neoplasm of the tracheobronchial system (HP:0100552)1.58289562
165Duodenal stenosis (HP:0100867)1.57946553
166Small intestinal stenosis (HP:0012848)1.57946553
167Constricted visual fields (HP:0001133)1.57865511
168Rectal fistula (HP:0100590)1.57408701
169Rectovaginal fistula (HP:0000143)1.57408701
170Preaxial hand polydactyly (HP:0001177)1.57165786

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.87918293
2TXK4.00404753
3MAP3K143.36503124
4BMPR23.33760716
5IRAK43.11402775
6TRIM283.09353887
7CASK2.74327343
8WNK32.63962488
9MAP3K122.47795893
10NLK2.36098560
11IRAK32.26677736
12SIK32.22296127
13MAP4K12.04172556
14ERBB32.02506912
15MAP4K21.98260114
16IKBKE1.96313078
17TEC1.90194879
18SGK21.87629848
19CCNB11.86923082
20MST41.83452887
21PLK41.80419177
22PRPF4B1.77027517
23KIT1.59362641
24BCKDK1.57580024
25JAK11.57325677
26FGFR21.55939065
27MAP3K41.54264211
28TAOK31.51436915
29OXSR11.51152230
30BCR1.45424393
31BRD41.44125945
32BTK1.43654493
33MAP2K71.42105530
34BMPR1B1.41952395
35CLK11.41295691
36MUSK1.40708742
37ACVR1B1.38190569
38IKBKB1.34183059
39CDK81.33716464
40VRK11.30122583
41TBK11.28603099
42STK101.26990602
43ZAP701.24529138
44STK38L1.22662434
45SYK1.20723269
46YES11.18409315
47AKT31.18364957
48JAK31.18111103
49CSF1R1.13820149
50SGK31.13459625
51PAK31.11025511
52NEK91.09703961
53EIF2AK21.09260292
54STK31.08884252
55PLK21.07829893
56PINK11.06033981
57NUAK11.05779088
58TYK21.03379348
59EPHA31.02834156
60RIPK41.01889044
61MAP3K61.00048502
62CAMKK20.95821296
63STK240.95376627
64LYN0.95244418
65MAP2K60.94916356
66MKNK20.94317142
67ADRBK20.91594535
68EPHA40.91049947
69NEK60.90414501
70ITK0.89304424
71STK110.89222270
72CDK30.88743561
73PIM10.88269591
74* CHUK0.87725719
75TGFBR20.86613296
76TGFBR10.86204026
77PRKCE0.84188677
78LCK0.83709039
79ATR0.83558779
80FES0.82110926
81BRAF0.81611584
82STK390.79128973
83BLK0.78601482
84KSR10.77562001
85PIM20.75653556
86GRK70.73215450
87TNIK0.72207669
88INSRR0.71037144
89MAP3K130.70968134
90CSNK1G10.70148468
91IRAK10.69834934
92TSSK60.69236110
93NTRK30.69226364
94GRK10.67300013
95BRSK20.66738316
96STK40.64447445
97MKNK10.63896455
98SGK4940.63858326
99SGK2230.63858326
100MAP2K40.63803412
101RPS6KB10.62739191
102PNCK0.61483607
103PTK2B0.61249772
104EIF2AK30.60778993
105MARK10.60645939
106MYLK0.60298086
107CSNK1G20.56701483
108FER0.56632738
109DAPK10.56182589
110RPS6KA40.55797505
111PLK30.55693652
112FGFR30.55205637
113ZAK0.54596386
114MAPK130.52097696
115RPS6KA60.50840171
116DYRK30.48706277
117CDC70.48182163
118DYRK1A0.47714096
119MOS0.47599541
120MAPKAPK50.47415101
121HCK0.47368678
122ADRBK10.47236646
123MAP3K50.46996267
124CSNK1A1L0.46538453
125FLT30.45861600
126PRKCG0.45681472
127CSNK1G30.44805784
128MAP3K20.44209832
129TNK20.43895220
130PASK0.43868000
131JAK20.43822628
132PRKCD0.43665974
133MARK30.42996088
134ABL10.42406936
135PIK3CG0.41620844
136CSNK1D0.41233980
137RPS6KL10.41021814
138RPS6KC10.41021814
139DAPK20.39898286
140PRKCQ0.38140555
141SRPK10.36512769
142ATM0.35746765
143CDK90.35652614
144IRAK20.34544477
145CDK190.33723041

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.69846263
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.69110261
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.49561660
4Caffeine metabolism_Homo sapiens_hsa002322.31876205
5Graft-versus-host disease_Homo sapiens_hsa053322.17709656
6Leishmaniasis_Homo sapiens_hsa051402.17141231
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16436462
8Measles_Homo sapiens_hsa051622.04343669
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93018157
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.92354868
11Dorso-ventral axis formation_Homo sapiens_hsa043201.87222693
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83717817
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80788500
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.73965289
15Butanoate metabolism_Homo sapiens_hsa006501.73164591
16Non-homologous end-joining_Homo sapiens_hsa034501.72830778
17Fanconi anemia pathway_Homo sapiens_hsa034601.72765925
18Hematopoietic cell lineage_Homo sapiens_hsa046401.68498851
19Propanoate metabolism_Homo sapiens_hsa006401.68092778
20Homologous recombination_Homo sapiens_hsa034401.67551729
21Base excision repair_Homo sapiens_hsa034101.63972929
22Herpes simplex infection_Homo sapiens_hsa051681.62671200
23Phototransduction_Homo sapiens_hsa047441.60993806
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58821114
25DNA replication_Homo sapiens_hsa030301.58029441
26Antigen processing and presentation_Homo sapiens_hsa046121.57687422
27Legionellosis_Homo sapiens_hsa051341.57084729
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56319493
29Nitrogen metabolism_Homo sapiens_hsa009101.54676439
30RNA degradation_Homo sapiens_hsa030181.53732341
31Type I diabetes mellitus_Homo sapiens_hsa049401.53376826
32Mismatch repair_Homo sapiens_hsa034301.49377380
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47488351
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47042833
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46468552
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43922926
37Nicotine addiction_Homo sapiens_hsa050331.43594254
38Cell cycle_Homo sapiens_hsa041101.43086338
39Allograft rejection_Homo sapiens_hsa053301.43040118
40Rheumatoid arthritis_Homo sapiens_hsa053231.41356323
41Osteoclast differentiation_Homo sapiens_hsa043801.40837685
42Basal transcription factors_Homo sapiens_hsa030221.40749208
43Tuberculosis_Homo sapiens_hsa051521.31303058
44B cell receptor signaling pathway_Homo sapiens_hsa046621.30943348
45Influenza A_Homo sapiens_hsa051641.27666852
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26808883
47* Jak-STAT signaling pathway_Homo sapiens_hsa046301.22738055
48Pertussis_Homo sapiens_hsa051331.21911467
49Ether lipid metabolism_Homo sapiens_hsa005651.16903052
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14603629
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13460153
52T cell receptor signaling pathway_Homo sapiens_hsa046601.09379744
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07624384
54Other glycan degradation_Homo sapiens_hsa005111.05902374
55Malaria_Homo sapiens_hsa051441.04670221
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02318642
57Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01957195
58Toxoplasmosis_Homo sapiens_hsa051451.00838011
59Hepatitis B_Homo sapiens_hsa051611.00188518
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99549147
61Linoleic acid metabolism_Homo sapiens_hsa005910.98536696
62Salmonella infection_Homo sapiens_hsa051320.97999530
63Peroxisome_Homo sapiens_hsa041460.96985711
64Nucleotide excision repair_Homo sapiens_hsa034200.96982613
65* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96315148
66ABC transporters_Homo sapiens_hsa020100.93630280
67Phagosome_Homo sapiens_hsa041450.93399872
68Chemokine signaling pathway_Homo sapiens_hsa040620.93027353
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92192997
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91923313
71Shigellosis_Homo sapiens_hsa051310.91679688
72Epstein-Barr virus infection_Homo sapiens_hsa051690.90684610
73Oocyte meiosis_Homo sapiens_hsa041140.89932316
74Autoimmune thyroid disease_Homo sapiens_hsa053200.89661021
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89513532
76p53 signaling pathway_Homo sapiens_hsa041150.88914298
77TNF signaling pathway_Homo sapiens_hsa046680.86598959
78Serotonergic synapse_Homo sapiens_hsa047260.86017266
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85201112
80Asthma_Homo sapiens_hsa053100.83726789
81Taste transduction_Homo sapiens_hsa047420.82671779
82Pancreatic cancer_Homo sapiens_hsa052120.80395268
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79631848
84Selenocompound metabolism_Homo sapiens_hsa004500.79010271
85Protein export_Homo sapiens_hsa030600.78754332
86Hedgehog signaling pathway_Homo sapiens_hsa043400.77593501
87Staphylococcus aureus infection_Homo sapiens_hsa051500.76587299
88Olfactory transduction_Homo sapiens_hsa047400.75459301
89Dopaminergic synapse_Homo sapiens_hsa047280.75063310
90Apoptosis_Homo sapiens_hsa042100.73764249
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71808987
92Circadian rhythm_Homo sapiens_hsa047100.71155174
93Collecting duct acid secretion_Homo sapiens_hsa049660.69132138
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68388230
95Colorectal cancer_Homo sapiens_hsa052100.67616017
96Prolactin signaling pathway_Homo sapiens_hsa049170.67424015
97RNA polymerase_Homo sapiens_hsa030200.65406285
98GABAergic synapse_Homo sapiens_hsa047270.64584114
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63887928
100Acute myeloid leukemia_Homo sapiens_hsa052210.63142809
101HTLV-I infection_Homo sapiens_hsa051660.63137488
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62835005
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62583529
104Long-term depression_Homo sapiens_hsa047300.62318574
105Insulin secretion_Homo sapiens_hsa049110.61564095
106Spliceosome_Homo sapiens_hsa030400.60920394
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59511949
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59479999
109Amphetamine addiction_Homo sapiens_hsa050310.58814331
110African trypanosomiasis_Homo sapiens_hsa051430.57784829
111Inositol phosphate metabolism_Homo sapiens_hsa005620.57561577
112Lysosome_Homo sapiens_hsa041420.57541461
113Platelet activation_Homo sapiens_hsa046110.57352959
114RNA transport_Homo sapiens_hsa030130.57234017
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57113418
116Viral myocarditis_Homo sapiens_hsa054160.56891879
117FoxO signaling pathway_Homo sapiens_hsa040680.56344573
118Tryptophan metabolism_Homo sapiens_hsa003800.53757480
119Pyrimidine metabolism_Homo sapiens_hsa002400.53248057
120Purine metabolism_Homo sapiens_hsa002300.53094840
121Viral carcinogenesis_Homo sapiens_hsa052030.52700179
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52084981
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52059893
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50407311
125Regulation of autophagy_Homo sapiens_hsa041400.50207277
126* Hepatitis C_Homo sapiens_hsa051600.48619302
127Type II diabetes mellitus_Homo sapiens_hsa049300.48545210
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.48488058
129N-Glycan biosynthesis_Homo sapiens_hsa005100.47596569
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.47148027
131mRNA surveillance pathway_Homo sapiens_hsa030150.47116262
132Circadian entrainment_Homo sapiens_hsa047130.46652857
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46182703
134Ovarian steroidogenesis_Homo sapiens_hsa049130.45929154
135TGF-beta signaling pathway_Homo sapiens_hsa043500.45709360
136Synaptic vesicle cycle_Homo sapiens_hsa047210.44686825
137mTOR signaling pathway_Homo sapiens_hsa041500.42332596
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.42306251
139Morphine addiction_Homo sapiens_hsa050320.41361286
140Thyroid cancer_Homo sapiens_hsa052160.41172810
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.40469232
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39670943
143MAPK signaling pathway_Homo sapiens_hsa040100.39364700
144Proteasome_Homo sapiens_hsa030500.39085693
145Primary bile acid biosynthesis_Homo sapiens_hsa001200.38794866
146Sphingolipid metabolism_Homo sapiens_hsa006000.37898481
147Renin secretion_Homo sapiens_hsa049240.36208702
148Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34687235
149Retinol metabolism_Homo sapiens_hsa008300.33817524
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.33124641

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