PIAS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.12259776
2cilium or flagellum-dependent cell motility (GO:0001539)5.63806537
3fusion of sperm to egg plasma membrane (GO:0007342)5.38726054
4male meiosis (GO:0007140)5.35055474
5sperm motility (GO:0030317)5.29556510
6sperm-egg recognition (GO:0035036)5.28302558
7synaptonemal complex assembly (GO:0007130)5.16601912
8binding of sperm to zona pellucida (GO:0007339)5.11673672
9synaptonemal complex organization (GO:0070193)5.04624045
10acrosome assembly (GO:0001675)4.99768020
11spermatid development (GO:0007286)4.70261230
12nuclear pore complex assembly (GO:0051292)4.63200341
13cell-cell recognition (GO:0009988)4.60347938
14nuclear pore organization (GO:0006999)4.53861455
15axonemal dynein complex assembly (GO:0070286)4.48174403
16epithelial cilium movement (GO:0003351)4.46790447
17cell wall macromolecule metabolic process (GO:0044036)4.44370616
18cell wall macromolecule catabolic process (GO:0016998)4.44370616
19regulation of cilium movement (GO:0003352)4.36379254
20DNA methylation involved in gamete generation (GO:0043046)4.32752085
21multicellular organism reproduction (GO:0032504)4.31764063
22motile cilium assembly (GO:0044458)4.11123928
23microtubule depolymerization (GO:0007019)4.08827466
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.05963173
25DNA replication-dependent nucleosome organization (GO:0034723)4.04960594
26DNA replication-dependent nucleosome assembly (GO:0006335)4.04960594
27acrosome reaction (GO:0007340)4.01448331
28mitotic sister chromatid cohesion (GO:0007064)4.00256840
29plasma membrane fusion (GO:0045026)3.97221185
30cilium movement (GO:0003341)3.90803893
31meiotic nuclear division (GO:0007126)3.89258479
32gamma-aminobutyric acid transport (GO:0015812)3.83912766
33chromosome organization involved in meiosis (GO:0070192)3.79500570
34regulation of centriole replication (GO:0046599)3.77393004
35gene silencing by RNA (GO:0031047)3.75687862
36behavioral response to nicotine (GO:0035095)3.74390625
37chaperone-mediated protein complex assembly (GO:0051131)3.64741755
38male meiosis I (GO:0007141)3.55532280
39presynaptic membrane assembly (GO:0097105)3.53874392
40L-fucose catabolic process (GO:0042355)3.50188343
41fucose catabolic process (GO:0019317)3.50188343
42L-fucose metabolic process (GO:0042354)3.50188343
43reproduction (GO:0000003)3.50012327
44regulation of histone H3-K9 methylation (GO:0051570)3.47057708
45sulfation (GO:0051923)3.44931770
46regulation of meiosis I (GO:0060631)3.37604561
47negative regulation of organelle assembly (GO:1902116)3.37022358
48chromosome condensation (GO:0030261)3.35856257
49male gamete generation (GO:0048232)3.28852071
50spermatogenesis (GO:0007283)3.28592796
51heterochromatin organization (GO:0070828)3.28554963
52germ cell development (GO:0007281)3.27277354
53response to pheromone (GO:0019236)3.24943466
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.23274411
55protein polyglutamylation (GO:0018095)3.22986964
56negative regulation of translation, ncRNA-mediated (GO:0040033)3.22691326
57regulation of translation, ncRNA-mediated (GO:0045974)3.22691326
58negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.22691326
59negative regulation of histone methylation (GO:0031061)3.22547661
60DNA packaging (GO:0006323)3.20873510
61negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19607360
62gene silencing (GO:0016458)3.18802080
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17526471
64pore complex assembly (GO:0046931)3.17466325
65replication fork processing (GO:0031297)3.17433318
66mitotic chromosome condensation (GO:0007076)3.16374408
67monoubiquitinated protein deubiquitination (GO:0035520)3.15599707
68regulation of DNA endoreduplication (GO:0032875)3.15452893
69sister chromatid segregation (GO:0000819)3.13446002
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.12815654
71meiosis I (GO:0007127)3.10313485
72pre-miRNA processing (GO:0031054)3.10202366
73mitotic sister chromatid segregation (GO:0000070)3.09403122
74regulation of centrosome cycle (GO:0046605)3.09007636
75microtubule severing (GO:0051013)3.07775556
76regulation of RNA export from nucleus (GO:0046831)3.07588303
77protein localization to chromosome, centromeric region (GO:0071459)3.07353678
78spliceosomal tri-snRNP complex assembly (GO:0000244)3.06527862
79regulation of microtubule-based movement (GO:0060632)3.06146208
80gamete generation (GO:0007276)3.05315943
81mitotic metaphase plate congression (GO:0007080)3.04614882
82paraxial mesoderm development (GO:0048339)3.04605988
83negative regulation of DNA-dependent DNA replication (GO:2000104)3.02892110
84regulation of gene silencing by RNA (GO:0060966)3.01726424
85regulation of posttranscriptional gene silencing (GO:0060147)3.01726424
86regulation of gene silencing by miRNA (GO:0060964)3.01726424
87meiotic cell cycle process (GO:1903046)2.99392379
88presynaptic membrane organization (GO:0097090)2.98517968
89indole-containing compound catabolic process (GO:0042436)2.98448104
90indolalkylamine catabolic process (GO:0046218)2.98448104
91tryptophan catabolic process (GO:0006569)2.98448104
92cellular process involved in reproduction in multicellular organism (GO:0022412)2.97951601
93regulation of chromosome segregation (GO:0051983)2.96438204
94mitotic nuclear envelope disassembly (GO:0007077)2.96101381
95DNA unwinding involved in DNA replication (GO:0006268)2.94946231
96indolalkylamine metabolic process (GO:0006586)2.94779334
97somite development (GO:0061053)2.92795382
98histone exchange (GO:0043486)2.92355192
99single fertilization (GO:0007338)2.90122956
100protein K11-linked deubiquitination (GO:0035871)2.89655506
101kidney morphogenesis (GO:0060993)2.89638878
102fertilization (GO:0009566)2.88527767
103negative regulation of DNA repair (GO:0045738)2.88011246
104dosage compensation (GO:0007549)2.86338530
105meiotic cell cycle (GO:0051321)2.85737962
106neuronal action potential (GO:0019228)2.84954615
107regulation of helicase activity (GO:0051095)2.83867023
108membrane disassembly (GO:0030397)2.82860281
109nuclear envelope disassembly (GO:0051081)2.82860281
110protein prenylation (GO:0018342)2.82159920
111prenylation (GO:0097354)2.82159920
112reflex (GO:0060004)2.81704943
113protein K6-linked ubiquitination (GO:0085020)2.81118689
114detection of light stimulus involved in sensory perception (GO:0050962)2.80700873
115detection of light stimulus involved in visual perception (GO:0050908)2.80700873
116positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.80353681
117positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.80353681
118positive regulation of mitotic sister chromatid separation (GO:1901970)2.80353681
119kynurenine metabolic process (GO:0070189)2.80055825
120synapsis (GO:0007129)2.79801645
121DNA methylation (GO:0006306)2.79314870
122DNA alkylation (GO:0006305)2.79314870
123serotonin metabolic process (GO:0042428)2.78582518
124protein localization to kinetochore (GO:0034501)2.78214647
125chromatin silencing (GO:0006342)2.76782698
126retinal cone cell development (GO:0046549)2.76607994
127positive regulation of chromosome segregation (GO:0051984)2.75346985
128regulation of centrosome duplication (GO:0010824)2.74791588
129intra-S DNA damage checkpoint (GO:0031573)2.74392728
130sperm capacitation (GO:0048240)2.74304568
131primary amino compound metabolic process (GO:1901160)2.74189254
132ventricular system development (GO:0021591)2.73832664
133water-soluble vitamin biosynthetic process (GO:0042364)2.72699866
134metaphase plate congression (GO:0051310)2.71905324
135DNA replication initiation (GO:0006270)2.71744512
136neural tube formation (GO:0001841)2.71571526
137negative regulation of chromosome segregation (GO:0051985)2.71031022
138axoneme assembly (GO:0035082)2.71011618
139interkinetic nuclear migration (GO:0022027)2.70549034
140tryptophan metabolic process (GO:0006568)2.69778661
141anterior/posterior axis specification, embryo (GO:0008595)2.67825656
142neuronal action potential propagation (GO:0019227)2.67396354
143indole-containing compound metabolic process (GO:0042430)2.66045256
144negative regulation of mitotic sister chromatid segregation (GO:0033048)2.64157887
145regulation of nuclear cell cycle DNA replication (GO:0033262)2.61366776
146DNA double-strand break processing (GO:0000729)2.60918923
147nonmotile primary cilium assembly (GO:0035058)2.58647300
148cAMP catabolic process (GO:0006198)2.58526047
149spinal cord motor neuron differentiation (GO:0021522)2.57741796
150cilium organization (GO:0044782)2.57623008
151regulation of mesoderm development (GO:2000380)2.56768339
152G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56422914
153cellular ketone body metabolic process (GO:0046950)2.51093947
154cilium assembly (GO:0042384)2.50859552
155protein localization to cilium (GO:0061512)2.49942775
156prostate gland growth (GO:0060736)2.48292790
157cyclic nucleotide catabolic process (GO:0009214)2.44563854
158membrane depolarization during action potential (GO:0086010)2.44551841
159mitochondrial respiratory chain complex I assembly (GO:0032981)2.44214231
160NADH dehydrogenase complex assembly (GO:0010257)2.44214231
161mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.44214231
162establishment of protein localization to Golgi (GO:0072600)2.43111705
163negative regulation of transcription regulatory region DNA binding (GO:2000678)2.43019478
164cilium morphogenesis (GO:0060271)2.42361605
165regulation of action potential (GO:0098900)2.39356568
166reciprocal meiotic recombination (GO:0007131)2.39199978
167reciprocal DNA recombination (GO:0035825)2.39199978
168microtubule anchoring (GO:0034453)2.39078920
169double-strand break repair via homologous recombination (GO:0000724)2.38754930
170recombinational repair (GO:0000725)2.38440899
171pyrimidine nucleobase catabolic process (GO:0006208)2.37962970
172startle response (GO:0001964)2.37671939
173regulation of telomere maintenance (GO:0032204)2.36090279
174regulation of hexokinase activity (GO:1903299)2.36033182
175regulation of glucokinase activity (GO:0033131)2.36033182
176ketone body metabolic process (GO:1902224)2.35674968
177negative regulation of mast cell activation (GO:0033004)2.35179188
178behavioral response to ethanol (GO:0048149)2.35066479
179cell proliferation in forebrain (GO:0021846)2.34522901
180photoreceptor cell maintenance (GO:0045494)2.34499216
181action potential (GO:0001508)2.31649233
182positive regulation of meiosis (GO:0045836)2.31614823
183maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.31251365
184limb bud formation (GO:0060174)2.30809717
185transmission of nerve impulse (GO:0019226)2.30494309
186postsynaptic membrane organization (GO:0001941)2.30426003
187RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.30259205
188dentate gyrus development (GO:0021542)2.28622085
189protein complex biogenesis (GO:0070271)2.25686546
190limb development (GO:0060173)2.23837260

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.71338821
2E2F7_22180533_ChIP-Seq_HELA_Human6.40026190
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.22592969
4GBX2_23144817_ChIP-Seq_PC3_Human3.66672209
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.49083171
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.04879093
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88411043
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.87373593
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.76875891
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.70905162
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.60877308
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.56753917
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.56753917
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.56753917
15VDR_22108803_ChIP-Seq_LS180_Human2.52907641
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.51623779
17TAF15_26573619_Chip-Seq_HEK293_Human2.49942634
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.43296178
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41433237
20IGF1R_20145208_ChIP-Seq_DFB_Human2.36490398
21EWS_26573619_Chip-Seq_HEK293_Human2.34845832
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.23623862
23P300_19829295_ChIP-Seq_ESCs_Human2.23452330
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.22346054
25SOX2_18555785_ChIP-Seq_MESCs_Mouse2.21760753
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21666710
27* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.17594224
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13111367
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.09045904
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.07762081
31CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05836010
32AR_21909140_ChIP-Seq_LNCAP_Human2.01603408
33FLI1_27457419_Chip-Seq_LIVER_Mouse2.00429350
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99737242
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99697185
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99671713
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98701497
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98408819
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.88371692
40SMAD4_21799915_ChIP-Seq_A2780_Human1.83646586
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.81750039
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.80978366
43ER_23166858_ChIP-Seq_MCF-7_Human1.79546855
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79443103
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77341350
46STAT3_23295773_ChIP-Seq_U87_Human1.73867354
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72799848
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.72122112
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71544029
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70925943
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70921393
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65560556
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64554561
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.64425403
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64079552
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.63766890
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.61948363
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.61590092
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61101211
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58701711
61CBP_20019798_ChIP-Seq_JUKART_Human1.58701711
62BCAT_22108803_ChIP-Seq_LS180_Human1.57181089
63AR_25329375_ChIP-Seq_VCAP_Human1.56564731
64* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55745751
65TCF4_23295773_ChIP-Seq_U87_Human1.55339962
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54330676
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54306179
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53480676
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51415676
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51415676
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.47586535
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47539352
73* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47078314
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.46951690
75EZH2_22144423_ChIP-Seq_EOC_Human1.44792024
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.44178081
77* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44089283
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.43062829
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42822888
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.42679780
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38853407
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38757672
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38638132
84AR_21572438_ChIP-Seq_LNCaP_Human1.38528751
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.37943865
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37345485
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35177163
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35048045
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33375533
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31891593
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31877134
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30916903
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.30742988
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.30737776
95RUNX2_22187159_ChIP-Seq_PCA_Human1.29599921
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29422868
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28390608
98TCF4_22108803_ChIP-Seq_LS180_Human1.28038633
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27782346
100NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.27215117
101ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26859855
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.26847283
103IRF1_19129219_ChIP-ChIP_H3396_Human1.25607951
104HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25029750
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.24743555
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.24294730
107POU5F1_16518401_ChIP-PET_MESCs_Mouse1.24194700
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24163625
109REST_21632747_ChIP-Seq_MESCs_Mouse1.22658338
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22375176
111SOX2_18692474_ChIP-Seq_MESCs_Mouse1.21770998
112POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.21314856
113ZNF274_21170338_ChIP-Seq_K562_Hela1.21021621
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20615235
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20170353
116PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19970737
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17153584
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16862254
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.16824370
120POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16222419
121SOX2_19829295_ChIP-Seq_ESCs_Human1.16044781
122NANOG_19829295_ChIP-Seq_ESCs_Human1.16044781
123SMAD4_21741376_ChIP-Seq_EPCs_Human1.15940475
124P53_22387025_ChIP-Seq_ESCs_Mouse1.15104404
125FUS_26573619_Chip-Seq_HEK293_Human1.14168036
126SOX2_21211035_ChIP-Seq_LN229_Gbm1.11573976
127MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11342068
128NANOG_18692474_ChIP-Seq_MESCs_Mouse1.11278814
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11016733
130STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10904812
131CRX_20693478_ChIP-Seq_RETINA_Mouse1.10366801
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09546085
133E2F1_18555785_Chip-Seq_ESCs_Mouse1.09529437
134PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09120470
135NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.09027030
136TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.07978227
137TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06684096
138TP63_19390658_ChIP-ChIP_HaCaT_Human1.06531939
139ARNT_22903824_ChIP-Seq_MCF-7_Human1.06377943
140TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06155098
141* TP53_22573176_ChIP-Seq_HFKS_Human1.06026780
142ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05906436
143RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05718643
144MYC_18940864_ChIP-ChIP_HL60_Human1.05503103
145STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05111884
146NANOG_16518401_ChIP-PET_MESCs_Mouse1.04956167
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03988851
148JUN_21703547_ChIP-Seq_K562_Human1.03242344
149KDM2B_26808549_Chip-Seq_REH_Human1.02806665
150KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02725618
151CDX2_22108803_ChIP-Seq_LS180_Human1.01066820
152FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01059994
153SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00051492
154TAL1_26923725_Chip-Seq_HPCs_Mouse0.99378890
155FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98571243
156PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.97808842
157OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97534237
158EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97454598
159CMYC_18555785_Chip-Seq_ESCs_Mouse0.96307820
160XRN2_22483619_ChIP-Seq_HELA_Human0.96122469
161POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.95551731
162SOX2_16153702_ChIP-ChIP_HESCs_Human0.94440604
163TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93401654
164ELK4_26923725_Chip-Seq_MESODERM_Mouse0.93252982
165NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93127002
166* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92260819
167TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91846841
168SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89370410
169RNF2_27304074_Chip-Seq_NSC_Mouse0.87633401
170STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87614902
171KDM5A_27292631_Chip-Seq_BREAST_Human0.87380697
172ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87133510
173* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84769137
174SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84632206
175E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.83222078
176KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82665905
177TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81513063
178SOX9_26525672_Chip-Seq_HEART_Mouse0.81401626
179WDR5_24793694_ChIP-Seq_LNCAP_Human0.80884995
180* KAP1_27257070_Chip-Seq_ESCs_Mouse0.79290877
181NANOG_16153702_ChIP-ChIP_HESCs_Human0.78883652
182ZFP281_27345836_Chip-Seq_ESCs_Mouse0.78150880
183PADI4_21655091_ChIP-ChIP_MCF-7_Human0.77020529
184TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.75734930
185KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75409268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.21469249
2MP0008877_abnormal_DNA_methylation3.45814182
3MP0002653_abnormal_ependyma_morphology3.38542504
4MP0008057_abnormal_DNA_replication3.09811101
5MP0003698_abnormal_male_reproductive2.93072881
6MP0001929_abnormal_gametogenesis2.91465404
7MP0010094_abnormal_chromosome_stability2.66481303
8MP0002102_abnormal_ear_morphology2.66425029
9MP0002210_abnormal_sex_determination2.57840055
10MP0003111_abnormal_nucleus_morphology2.52089610
11MP0003123_paternal_imprinting2.37634815
12MP0004957_abnormal_blastocyst_morpholog2.29498710
13MP0003195_calcinosis2.25603211
14MP0008058_abnormal_DNA_repair2.23601844
15MP0001145_abnormal_male_reproductive2.23082162
16MP0002837_dystrophic_cardiac_calcinosis2.21992772
17MP0005646_abnormal_pituitary_gland2.15485827
18MP0009046_muscle_twitch2.09816880
19MP0003121_genomic_imprinting2.05549174
20MP0004133_heterotaxia2.05357487
21MP0003077_abnormal_cell_cycle2.05135073
22MP0003646_muscle_fatigue2.05067231
23MP0005551_abnormal_eye_electrophysiolog2.04030366
24MP0003693_abnormal_embryo_hatching2.00646536
25MP0003890_abnormal_embryonic-extraembry1.98886364
26MP0001968_abnormal_touch/_nociception1.98647313
27MP0000653_abnormal_sex_gland1.90903611
28MP0009745_abnormal_behavioral_response1.87862151
29MP0010030_abnormal_orbit_morphology1.86873988
30MP0000537_abnormal_urethra_morphology1.84789591
31MP0003880_abnormal_central_pattern1.84016570
32MP0003119_abnormal_digestive_system1.80474919
33MP0003283_abnormal_digestive_organ1.79311929
34MP0001730_embryonic_growth_arrest1.77221404
35MP0002272_abnormal_nervous_system1.77020657
36MP0004145_abnormal_muscle_electrophysio1.76772058
37MP0005253_abnormal_eye_physiology1.76445340
38MP0002161_abnormal_fertility/fecundity1.75777568
39MP0005623_abnormal_meninges_morphology1.73100672
40MP0002084_abnormal_developmental_patter1.71193454
41MP0001486_abnormal_startle_reflex1.70196072
42MP0003787_abnormal_imprinting1.67899652
43MP0002735_abnormal_chemical_nociception1.63589947
44MP0002938_white_spotting1.63363624
45MP0004197_abnormal_fetal_growth/weight/1.60575632
46MP0004142_abnormal_muscle_tone1.59543626
47MP0002085_abnormal_embryonic_tissue1.58153991
48MP0002736_abnormal_nociception_after1.57214559
49MP0008007_abnormal_cellular_replicative1.54205209
50MP0004233_abnormal_muscle_weight1.53033560
51MP0001672_abnormal_embryogenesis/_devel1.48063905
52MP0005380_embryogenesis_phenotype1.48063905
53MP0001293_anophthalmia1.46622488
54MP0002282_abnormal_trachea_morphology1.44853197
55MP0002638_abnormal_pupillary_reflex1.43315669
56MP0000427_abnormal_hair_cycle1.42710290
57MP0003786_premature_aging1.42189132
58MP0000372_irregular_coat_pigmentation1.40707976
59MP0000350_abnormal_cell_proliferation1.40351614
60MP0004215_abnormal_myocardial_fiber1.40312508
61MP0002160_abnormal_reproductive_system1.40018501
62MP0002064_seizures1.39992322
63MP0008932_abnormal_embryonic_tissue1.39878105
64MP0005645_abnormal_hypothalamus_physiol1.39790891
65MP0001697_abnormal_embryo_size1.39512880
66MP0004043_abnormal_pH_regulation1.35430524
67MP0003635_abnormal_synaptic_transmissio1.33697975
68MP0001986_abnormal_taste_sensitivity1.31901339
69MP0002557_abnormal_social/conspecific_i1.31888608
70MP0003984_embryonic_growth_retardation1.29930396
71MP0001501_abnormal_sleep_pattern1.28262142
72MP0002088_abnormal_embryonic_growth/wei1.28067085
73MP0003861_abnormal_nervous_system1.26591950
74MP0005386_behavior/neurological_phenoty1.26443034
75MP0004924_abnormal_behavior1.26443034
76MP0002734_abnormal_mechanical_nocicepti1.26187326
77MP0010352_gastrointestinal_tract_polyps1.25529590
78MP0008995_early_reproductive_senescence1.24846100
79MP0002572_abnormal_emotion/affect_behav1.22683235
80MP0008872_abnormal_physiological_respon1.21831436
81MP0003136_yellow_coat_color1.21746931
82MP0003122_maternal_imprinting1.20762241
83MP0005076_abnormal_cell_differentiation1.20485302
84MP0009053_abnormal_anal_canal1.19055869
85MP0000383_abnormal_hair_follicle1.18502114
86MP0003315_abnormal_perineum_morphology1.17479335
87MP0003937_abnormal_limbs/digits/tail_de1.16925554
88MP0005174_abnormal_tail_pigmentation1.15544015
89MP0002876_abnormal_thyroid_physiology1.14802694
90MP0002067_abnormal_sensory_capabilities1.12860079
91MP0002063_abnormal_learning/memory/cond1.12793658
92MP0002086_abnormal_extraembryonic_tissu1.10424012
93MP0002080_prenatal_lethality1.07849389
94MP0000428_abnormal_craniofacial_morphol1.06706254
95MP0006276_abnormal_autonomic_nervous1.05830608
96MP0000534_abnormal_ureter_morphology1.04496755
97MP0002163_abnormal_gland_morphology1.04470015
98MP0002697_abnormal_eye_size1.04406403
99MP0002928_abnormal_bile_duct1.03419034
100MP0003115_abnormal_respiratory_system1.02858931
101MP0005379_endocrine/exocrine_gland_phen1.01325504
102MP0003755_abnormal_palate_morphology1.00791172
103MP0001970_abnormal_pain_threshold0.99774520
104MP0003705_abnormal_hypodermis_morpholog0.99580933
105MP0009703_decreased_birth_body0.99564181
106MP0002138_abnormal_hepatobiliary_system0.97165903
107MP0002909_abnormal_adrenal_gland0.96610401
108MP0001286_abnormal_eye_development0.95999015
109MP0008789_abnormal_olfactory_epithelium0.95649395
110MP0002751_abnormal_autonomic_nervous0.95577299
111MP0006072_abnormal_retinal_apoptosis0.95313515
112MP0000778_abnormal_nervous_system0.94829959
113MP0004085_abnormal_heartbeat0.94715678
114MP0000569_abnormal_digit_pigmentation0.94681298
115MP0004270_analgesia0.94477062
116MP0002733_abnormal_thermal_nociception0.94301844
117MP0003935_abnormal_craniofacial_develop0.94210994
118MP0003942_abnormal_urinary_system0.93888808
119MP0002092_abnormal_eye_morphology0.93231777
120MP0000432_abnormal_head_morphology0.92367879
121MP0005670_abnormal_white_adipose0.92181386
122MP0005195_abnormal_posterior_eye0.92028963
123MP0005389_reproductive_system_phenotype0.91213126
124MP0010307_abnormal_tumor_latency0.91067334
125MP0002184_abnormal_innervation0.89499151
126MP0003137_abnormal_impulse_conducting0.88505295
127MP0003567_abnormal_fetal_cardiomyocyte0.88116033
128MP0001440_abnormal_grooming_behavior0.87295162
129MP0009780_abnormal_chondrocyte_physiolo0.86920704
130MP0006292_abnormal_olfactory_placode0.86848022
131MP0005187_abnormal_penis_morphology0.86814700
132MP0003011_delayed_dark_adaptation0.85835293
133MP0002116_abnormal_craniofacial_bone0.84926850
134MP0002752_abnormal_somatic_nervous0.84580441
135MP0003938_abnormal_ear_development0.84434741
136MP0001188_hyperpigmentation0.83691074
137MP0004885_abnormal_endolymph0.82197701
138MP0009672_abnormal_birth_weight0.82151191
139MP0003936_abnormal_reproductive_system0.81694463
140MP0002152_abnormal_brain_morphology0.81264031
141MP0001984_abnormal_olfaction0.80814352
142MP0002114_abnormal_axial_skeleton0.80762663
143MP0001529_abnormal_vocalization0.79532430
144MP0002111_abnormal_tail_morphology0.79235008
145MP0001299_abnormal_eye_distance/0.78654781
146MP0004264_abnormal_extraembryonic_tissu0.78412007
147MP0003718_maternal_effect0.77876204
148MP0004859_abnormal_synaptic_plasticity0.77043698
149MP0000230_abnormal_systemic_arterial0.76821245
150MP0010678_abnormal_skin_adnexa0.76721768
151MP0000955_abnormal_spinal_cord0.75759030
152MP0000733_abnormal_muscle_development0.75349510
153MP0000026_abnormal_inner_ear0.75259699
154MP0004134_abnormal_chest_morphology0.74350225
155MP0000631_abnormal_neuroendocrine_gland0.73631578
156MP0005391_vision/eye_phenotype0.73561257
157MP0002233_abnormal_nose_morphology0.71166361
158MP0003385_abnormal_body_wall0.70496967
159MP0001485_abnormal_pinna_reflex0.70304241
160MP0001119_abnormal_female_reproductive0.70113834
161MP0000049_abnormal_middle_ear0.69748316
162MP0002932_abnormal_joint_morphology0.68591751
163MP0002234_abnormal_pharynx_morphology0.67461955
164MP0002081_perinatal_lethality0.66732687
165MP0000462_abnormal_digestive_system0.66093037
166MP0003699_abnormal_female_reproductive0.66008948
167MP0002249_abnormal_larynx_morphology0.64333243
168MP0000516_abnormal_urinary_system0.62752439

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.35427057
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.72568015
3Absent/shortened dynein arms (HP:0200106)5.72568015
4Abnormal respiratory motile cilium physiology (HP:0012261)4.37546714
5Pancreatic cysts (HP:0001737)4.04251974
6Pancreatic fibrosis (HP:0100732)3.84984501
7Abnormal respiratory epithelium morphology (HP:0012253)3.80259462
8Abnormal respiratory motile cilium morphology (HP:0005938)3.80259462
9True hermaphroditism (HP:0010459)3.62870493
10Rhinitis (HP:0012384)3.54919003
11Abnormality of the lower motor neuron (HP:0002366)3.51235684
12Abnormal ciliary motility (HP:0012262)3.50937590
13Chronic bronchitis (HP:0004469)3.49464024
14Hyperventilation (HP:0002883)3.49118311
15Gaze-evoked nystagmus (HP:0000640)3.22832737
16Ependymoma (HP:0002888)3.15257665
17Abnormality of the labia minora (HP:0012880)3.09314086
18Supernumerary spleens (HP:0009799)3.06778006
19Infertility (HP:0000789)2.99287287
20Congenital stationary night blindness (HP:0007642)2.87963657
21Abnormality of the renal cortex (HP:0011035)2.86159488
22Febrile seizures (HP:0002373)2.85998229
23Progressive cerebellar ataxia (HP:0002073)2.85195750
24Genetic anticipation (HP:0003743)2.81724979
25Impulsivity (HP:0100710)2.79763533
26Male infertility (HP:0003251)2.74168578
27Medial flaring of the eyebrow (HP:0010747)2.73934424
28Chronic hepatic failure (HP:0100626)2.73882419
29Abnormality of the astrocytes (HP:0100707)2.67097492
30Astrocytoma (HP:0009592)2.67097492
31Broad-based gait (HP:0002136)2.64093140
32Protruding tongue (HP:0010808)2.52936323
33Cystic liver disease (HP:0006706)2.52386150
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.41591035
35Neoplasm of the oral cavity (HP:0100649)2.40043721
36Abolished electroretinogram (ERG) (HP:0000550)2.39598232
37Selective tooth agenesis (HP:0001592)2.36300268
38Attenuation of retinal blood vessels (HP:0007843)2.35957752
39Medulloblastoma (HP:0002885)2.35191806
40Short ribs (HP:0000773)2.28943417
41Amyotrophic lateral sclerosis (HP:0007354)2.24676733
42Gait imbalance (HP:0002141)2.24613365
43Hemiparesis (HP:0001269)2.24612244
44Furrowed tongue (HP:0000221)2.23454222
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.22779047
46Genital tract atresia (HP:0001827)2.21352273
47Neoplasm of the adrenal cortex (HP:0100641)2.21308046
48Nephronophthisis (HP:0000090)2.20927240
49Polydipsia (HP:0001959)2.20200189
50Abnormal drinking behavior (HP:0030082)2.20200189
51Intestinal atresia (HP:0011100)2.19869298
52Pendular nystagmus (HP:0012043)2.16067907
53Congenital primary aphakia (HP:0007707)2.15263058
54Birth length less than 3rd percentile (HP:0003561)2.14042998
55Absent speech (HP:0001344)2.13604409
56Renal cortical cysts (HP:0000803)2.13041053
57Glioma (HP:0009733)2.11809552
58Missing ribs (HP:0000921)2.11804292
59Drooling (HP:0002307)2.10717576
60Nephroblastoma (Wilms tumor) (HP:0002667)2.10441499
61Vaginal atresia (HP:0000148)2.09718727
62Heterotopia (HP:0002282)2.07918221
63Short hallux (HP:0010109)2.05932498
64Abnormality of the anterior horn cell (HP:0006802)2.05300346
65Degeneration of anterior horn cells (HP:0002398)2.05300346
66Hypoplastic labia majora (HP:0000059)2.05150718
67Abdominal situs inversus (HP:0003363)2.03847847
68Abnormality of abdominal situs (HP:0011620)2.03847847
69Small hand (HP:0200055)2.03292702
70Aplasia/Hypoplasia of the hallux (HP:0008362)2.02655300
71Sclerocornea (HP:0000647)2.01745853
72Progressive inability to walk (HP:0002505)2.01544761
73Short humerus (HP:0005792)2.00889126
74Congenital, generalized hypertrichosis (HP:0004540)2.00303581
75Fair hair (HP:0002286)1.98721189
76Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.98608237
77Short 1st metacarpal (HP:0010034)1.98608237
78Aplasia/Hypoplasia of the sternum (HP:0006714)1.97539792
79Facial cleft (HP:0002006)1.97406277
80Inability to walk (HP:0002540)1.97183658
81Keratoconus (HP:0000563)1.97023154
82Increased corneal curvature (HP:0100692)1.97023154
83Male pseudohermaphroditism (HP:0000037)1.96666289
84Fibular hypoplasia (HP:0003038)1.94953401
85Short 4th metacarpal (HP:0010044)1.94789847
86Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.94789847
87Nephrogenic diabetes insipidus (HP:0009806)1.94777669
88Aplasia/hypoplasia of the humerus (HP:0006507)1.93139416
89Embryonal renal neoplasm (HP:0011794)1.92968640
90Type II lissencephaly (HP:0007260)1.91668346
91Focal seizures (HP:0007359)1.91257101
92Neoplasm of striated muscle (HP:0009728)1.89335437
93Congenital hepatic fibrosis (HP:0002612)1.89317375
94Shoulder girdle muscle weakness (HP:0003547)1.88452964
95Congenital sensorineural hearing impairment (HP:0008527)1.88005521
96Abnormal biliary tract physiology (HP:0012439)1.86355274
97Bile duct proliferation (HP:0001408)1.86355274
98Anencephaly (HP:0002323)1.86104204
99Abnormality of the labia majora (HP:0012881)1.85619034
100Bony spicule pigmentary retinopathy (HP:0007737)1.85248719
101Widely spaced teeth (HP:0000687)1.84965719
102Optic nerve hypoplasia (HP:0000609)1.84870194
103Stomach cancer (HP:0012126)1.84135342
104Abnormal spermatogenesis (HP:0008669)1.84096465
105Abnormal rod and cone electroretinograms (HP:0008323)1.83815629
106Excessive salivation (HP:0003781)1.82349431
107Postaxial foot polydactyly (HP:0001830)1.82181612
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81496570
109Renal duplication (HP:0000075)1.81130319
110Poor coordination (HP:0002370)1.80204190
111Polyuria (HP:0000103)1.79603189
112Microglossia (HP:0000171)1.78766484
113Breast hypoplasia (HP:0003187)1.78750355
114Ectopic kidney (HP:0000086)1.78126052
115Patellar aplasia (HP:0006443)1.78101093
116Hypothermia (HP:0002045)1.76330797
117Methylmalonic acidemia (HP:0002912)1.76034171
118Metaphyseal cupping (HP:0003021)1.74691894
119Hypomagnesemia (HP:0002917)1.73678290
120Postaxial hand polydactyly (HP:0001162)1.73173960
121Aplasia/Hypoplasia of the patella (HP:0006498)1.73112372
122Focal motor seizures (HP:0011153)1.73028947
123Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72571568
124Decreased central vision (HP:0007663)1.72447806
125Short tibia (HP:0005736)1.71177027
126Meckel diverticulum (HP:0002245)1.70646947
127Hypopigmentation of the fundus (HP:0007894)1.69269150
128Dialeptic seizures (HP:0011146)1.69249030
129Astigmatism (HP:0000483)1.68701598
130Increased nuchal translucency (HP:0010880)1.68335975
131Epileptic encephalopathy (HP:0200134)1.67507168
132Abnormality of the 1st metacarpal (HP:0010009)1.66912309
133Volvulus (HP:0002580)1.66684156
134Chorioretinal atrophy (HP:0000533)1.66222835
135Biliary tract neoplasm (HP:0100574)1.65995371
136Abnormality of the renal medulla (HP:0100957)1.65830148
137Hepatoblastoma (HP:0002884)1.65302131
138Abnormality of cochlea (HP:0000375)1.65257789
139Sex reversal (HP:0012245)1.64828992
140Abnormal sex determination (HP:0012244)1.64828992
141Median cleft lip (HP:0000161)1.64736388
142Atrophy/Degeneration involving motor neurons (HP:0007373)1.63675267
143Colon cancer (HP:0003003)1.63427400
144Absent radius (HP:0003974)1.63213317
145Sloping forehead (HP:0000340)1.63004470
146Lissencephaly (HP:0001339)1.62892241
147Shawl scrotum (HP:0000049)1.62706218
148Specific learning disability (HP:0001328)1.62608753
149Abnormality of the ileum (HP:0001549)1.61760918
150Aplasia/Hypoplasia of the uvula (HP:0010293)1.61331002
151Dyskinesia (HP:0100660)1.60961050
152Tubulointerstitial nephritis (HP:0001970)1.60783546
153Broad alveolar ridges (HP:0000187)1.60581422
154Tubular atrophy (HP:0000092)1.60566891
155Pelvic girdle muscle weakness (HP:0003749)1.60073350
15611 pairs of ribs (HP:0000878)1.59241502
157Supernumerary ribs (HP:0005815)1.58998885
158Bronchiectasis (HP:0002110)1.58857352
159Neoplasm of the heart (HP:0100544)1.58237939
160Abnormality of chromosome stability (HP:0003220)1.57249087
161Rhabdomyosarcoma (HP:0002859)1.56329295
162Absent forearm bone (HP:0003953)1.56161921
163Aplasia involving forearm bones (HP:0009822)1.56161921
164Hypoplastic ischia (HP:0003175)1.54676362
165Gonadotropin excess (HP:0000837)1.53497080
166Aplasia/Hypoplasia of the fibula (HP:0006492)1.53180839
167Abnormality of chromosome segregation (HP:0002916)1.52902950
168Papillary thyroid carcinoma (HP:0002895)1.52333053
169Oligodactyly (hands) (HP:0001180)1.51935464
170Renovascular hypertension (HP:0100817)1.51268197
171Rhizomelia (HP:0008905)1.51158721
172Abnormality of the labia (HP:0000058)1.50291744
173Duodenal stenosis (HP:0100867)1.49683919
174Small intestinal stenosis (HP:0012848)1.49683919
175Oligodactyly (HP:0012165)1.49298129
176Esophageal atresia (HP:0002032)1.47041581
177Molar tooth sign on MRI (HP:0002419)1.46771316
178Abnormality of midbrain morphology (HP:0002418)1.46771316
179Irregular epiphyses (HP:0010582)1.46233796
180Mild short stature (HP:0003502)1.46139225
181Facial hemangioma (HP:0000329)1.46113733
182Abnormality of the 4th metacarpal (HP:0010012)1.45583153

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.40433503
2PDK44.47205146
3PDK34.47205146
4PNCK3.28535083
5CDC73.22378313
6BMPR1B3.17367107
7PDK23.06466700
8PRKD32.99684287
9ICK2.61332228
10NEK22.58873154
11MAP4K22.57083235
12CDK122.51832895
13WEE12.49906167
14CASK2.45023651
15ZAK2.36610243
16TTK2.29614885
17NUAK12.19822845
18TESK12.19515492
19NEK12.12270797
20TNIK2.05737083
21GRK12.01086193
22PASK1.91259407
23ADRBK21.89013110
24PINK11.86467004
25MAPK131.78698964
26INSRR1.72494857
27TYRO31.70472685
28BUB11.68030581
29OXSR11.56477375
30CHEK21.55585253
31PLK21.48468244
32TLK11.46118925
33PLK11.37075285
34SRPK11.36108564
35BRD41.35547023
36ATR1.33824125
37PLK31.33679333
38OBSCN1.32812827
39CHEK11.32639950
40TIE11.24607571
41EPHA21.24431486
42KSR11.20613594
43ACVR1B1.19540470
44DYRK31.19052883
45TAOK31.18394228
46AKT31.17114552
47MKNK21.15707686
48MAP2K71.15613415
49STK38L1.13158809
50LATS11.08810643
51SGK21.08151134
52NTRK31.04679038
53PHKG21.03726333
54PHKG11.03726333
55TRIM281.03222650
56STK391.00493510
57ATM1.00320145
58EIF2AK10.99786203
59CSNK1G10.98286630
60MAP3K40.97686447
61MELK0.96417310
62MKNK10.95236479
63CSNK1G20.94898605
64TAF10.94462396
65BCR0.94293600
66WNK30.94145065
67STK30.92606365
68PRKCE0.91904091
69WNK40.91151908
70STK380.89839898
71TGFBR10.89568175
72DDR20.88185867
73DAPK20.87066073
74MTOR0.86469039
75PTK2B0.86123499
76PAK60.85880714
77CDK20.84611253
78EPHA40.84589178
79SCYL20.83261207
80NTRK20.82587016
81CDK70.79920028
82TSSK60.79848226
83CSNK1A1L0.79286787
84RPS6KB20.77724366
85BRSK20.77507733
86TESK20.77036571
87CSNK1G30.75288240
88SGK2230.74807176
89SGK4940.74807176
90EIF2AK30.74703399
91NLK0.74382996
92AURKB0.73057416
93CDK10.72093597
94MARK10.71323065
95DYRK1B0.70175657
96ADRBK10.69782026
97WNK10.69514361
98BRSK10.69074578
99LATS20.67051420
100CDK60.66789496
101CDK40.64812761
102MET0.64470218
103AURKA0.64143406
104CSNK1D0.63464541
105VRK10.62077146
106ERBB30.61481474
107UHMK10.61012273
108PDGFRA0.60804497
109MAP3K100.60083680
110CSNK1E0.59270300
111TEC0.57804575
112FGFR10.55626268
113CDK30.54381458
114PAK40.54292724
115PRKDC0.53847120
116CDK140.53680571
117PIK3CA0.52856747
118NEK60.52836875
119CAMK2A0.52789048
120CDK180.52534302
121CDK150.51560424
122CAMK1G0.50807622
123PLK40.50523864
124DYRK1A0.49694205
125SGK10.49224564
126CCNB10.48680803
127ALK0.48582371
128MAP3K80.48248402
129CAMKK20.45697931
130MAPK100.45527136
131GSK3B0.45424821
132FLT30.44559794
133PRKACA0.44262731
134STK110.44094789
135PRKG10.43764261
136DYRK20.43155666
137CDK11A0.43002743
138PAK20.42250441
139CAMK10.41469286
140PRKAA10.39611117
141MUSK0.39497957
142PRKCG0.39429893
143MAP3K90.39338870
144FER0.39330183
145PKN10.39223861
146CSNK1A10.38140700
147MAP2K40.36426271
148MAPK140.35319659
149PRKAA20.34699963
150SGK30.34075375
151PAK10.33891748
152PAK30.33760355
153RPS6KB10.33648995
154KSR20.31355909
155CSNK2A20.31213432
156CAMK40.31067082
157RPS6KA50.30995205
158MAP2K10.30970536
159PRKACB0.30314209
160ERBB20.30209081
161PRKCH0.30148584
162FGFR20.30114222
163BRAF0.29274581
164AKT20.27970517

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030133.35947149
2Mismatch repair_Homo sapiens_hsa034303.03618609
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88259863
4mRNA surveillance pathway_Homo sapiens_hsa030152.87085905
5DNA replication_Homo sapiens_hsa030302.74161376
6Cell cycle_Homo sapiens_hsa041102.68962832
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59045052
8Basal transcription factors_Homo sapiens_hsa030222.58117685
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55629841
10Fanconi anemia pathway_Homo sapiens_hsa034602.55252539
11Oocyte meiosis_Homo sapiens_hsa041142.46090864
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.45596909
13Phototransduction_Homo sapiens_hsa047442.44375079
14Spliceosome_Homo sapiens_hsa030402.42824659
15Butanoate metabolism_Homo sapiens_hsa006502.33522086
16One carbon pool by folate_Homo sapiens_hsa006702.17392167
17* Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.14516816
18Nucleotide excision repair_Homo sapiens_hsa034202.06956942
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04163841
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01885007
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.92400264
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.86000123
23Taste transduction_Homo sapiens_hsa047421.82550439
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.80673372
25Homologous recombination_Homo sapiens_hsa034401.76229252
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72091266
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.69181371
28Selenocompound metabolism_Homo sapiens_hsa004501.68629335
29RNA degradation_Homo sapiens_hsa030181.60981992
30Basal cell carcinoma_Homo sapiens_hsa052171.58631510
31Morphine addiction_Homo sapiens_hsa050321.57869988
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56350955
33Hedgehog signaling pathway_Homo sapiens_hsa043401.55284448
34Hippo signaling pathway_Homo sapiens_hsa043901.54421354
35Tryptophan metabolism_Homo sapiens_hsa003801.49042704
36Protein export_Homo sapiens_hsa030601.47999709
37Base excision repair_Homo sapiens_hsa034101.47253266
38Circadian entrainment_Homo sapiens_hsa047131.47191725
39Olfactory transduction_Homo sapiens_hsa047401.46701120
40Glutamatergic synapse_Homo sapiens_hsa047241.43530966
41Dorso-ventral axis formation_Homo sapiens_hsa043201.42212717
42Ether lipid metabolism_Homo sapiens_hsa005651.40773958
43Non-homologous end-joining_Homo sapiens_hsa034501.39926127
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38651860
45Biosynthesis of amino acids_Homo sapiens_hsa012301.36316282
46GABAergic synapse_Homo sapiens_hsa047271.36315329
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36004275
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35913398
49Pyruvate metabolism_Homo sapiens_hsa006201.33574653
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32833032
51Glucagon signaling pathway_Homo sapiens_hsa049221.29505317
52Lysine degradation_Homo sapiens_hsa003101.28186292
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.26321163
54Fatty acid biosynthesis_Homo sapiens_hsa000611.21901583
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18077852
56Serotonergic synapse_Homo sapiens_hsa047261.17853923
57mTOR signaling pathway_Homo sapiens_hsa041501.16792951
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16152968
59ABC transporters_Homo sapiens_hsa020101.11374827
60Vitamin B6 metabolism_Homo sapiens_hsa007501.08479161
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07832600
62Wnt signaling pathway_Homo sapiens_hsa043101.06849010
63TGF-beta signaling pathway_Homo sapiens_hsa043501.06395494
64Oxidative phosphorylation_Homo sapiens_hsa001901.06217919
65Tight junction_Homo sapiens_hsa045301.05593131
66Regulation of autophagy_Homo sapiens_hsa041401.01725338
67Steroid hormone biosynthesis_Homo sapiens_hsa001401.00618052
68Calcium signaling pathway_Homo sapiens_hsa040201.00377741
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00105528
70p53 signaling pathway_Homo sapiens_hsa041150.94282317
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93967311
72Salivary secretion_Homo sapiens_hsa049700.92944068
73Retinol metabolism_Homo sapiens_hsa008300.90622352
74Amphetamine addiction_Homo sapiens_hsa050310.90344383
75Cardiac muscle contraction_Homo sapiens_hsa042600.88400954
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.88311358
77Pyrimidine metabolism_Homo sapiens_hsa002400.87406376
78Adherens junction_Homo sapiens_hsa045200.86891235
79Carbon metabolism_Homo sapiens_hsa012000.86087074
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85025522
81Caffeine metabolism_Homo sapiens_hsa002320.84548783
82Renin secretion_Homo sapiens_hsa049240.84248271
83Peroxisome_Homo sapiens_hsa041460.83857650
84RNA polymerase_Homo sapiens_hsa030200.83463894
85MicroRNAs in cancer_Homo sapiens_hsa052060.83108831
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81839319
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.81684743
88Long-term depression_Homo sapiens_hsa047300.80577215
89Alcoholism_Homo sapiens_hsa050340.79928928
90Ovarian steroidogenesis_Homo sapiens_hsa049130.79754621
91Systemic lupus erythematosus_Homo sapiens_hsa053220.78353031
92beta-Alanine metabolism_Homo sapiens_hsa004100.78090014
93Long-term potentiation_Homo sapiens_hsa047200.77735575
94Purine metabolism_Homo sapiens_hsa002300.76869362
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76814222
96Nitrogen metabolism_Homo sapiens_hsa009100.75739144
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75585883
98AMPK signaling pathway_Homo sapiens_hsa041520.75546542
99Propanoate metabolism_Homo sapiens_hsa006400.74818452
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.71750663
101Chemical carcinogenesis_Homo sapiens_hsa052040.70092273
102Sulfur metabolism_Homo sapiens_hsa009200.69676908
103Parkinsons disease_Homo sapiens_hsa050120.68822870
104Linoleic acid metabolism_Homo sapiens_hsa005910.68349910
105Notch signaling pathway_Homo sapiens_hsa043300.67639276
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66904982
107Viral carcinogenesis_Homo sapiens_hsa052030.66796631
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65990792
109Huntingtons disease_Homo sapiens_hsa050160.65881889
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64935226
111Oxytocin signaling pathway_Homo sapiens_hsa049210.64249721
112Type II diabetes mellitus_Homo sapiens_hsa049300.63161346
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62194070
114cAMP signaling pathway_Homo sapiens_hsa040240.61780939
115Cholinergic synapse_Homo sapiens_hsa047250.60297290
116Colorectal cancer_Homo sapiens_hsa052100.60199807
117Fructose and mannose metabolism_Homo sapiens_hsa000510.59690896
118Gastric acid secretion_Homo sapiens_hsa049710.59501585
119Fatty acid degradation_Homo sapiens_hsa000710.59331272
120HTLV-I infection_Homo sapiens_hsa051660.56657173
121Estrogen signaling pathway_Homo sapiens_hsa049150.56419782
122Axon guidance_Homo sapiens_hsa043600.56200241
123Steroid biosynthesis_Homo sapiens_hsa001000.56164810
124Alzheimers disease_Homo sapiens_hsa050100.55469197
125Prostate cancer_Homo sapiens_hsa052150.55404906
126Pentose phosphate pathway_Homo sapiens_hsa000300.51686926
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51616816
128Arachidonic acid metabolism_Homo sapiens_hsa005900.51546639
129Glycerolipid metabolism_Homo sapiens_hsa005610.50271101
130Cocaine addiction_Homo sapiens_hsa050300.49556387
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47179479
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46763825
133Circadian rhythm_Homo sapiens_hsa047100.46663784
134Collecting duct acid secretion_Homo sapiens_hsa049660.45823337
135Histidine metabolism_Homo sapiens_hsa003400.45514216
136Epstein-Barr virus infection_Homo sapiens_hsa051690.45079946
137Fatty acid metabolism_Homo sapiens_hsa012120.42065154
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.41805140
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40283041
140Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39652769
141Nicotine addiction_Homo sapiens_hsa050330.38772025
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37885160
143Dopaminergic synapse_Homo sapiens_hsa047280.37081614
144Endometrial cancer_Homo sapiens_hsa052130.34679193
145Renal cell carcinoma_Homo sapiens_hsa052110.34298227
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33623363
147Gap junction_Homo sapiens_hsa045400.32839860
148Insulin secretion_Homo sapiens_hsa049110.32806238
149Protein digestion and absorption_Homo sapiens_hsa049740.32097182
150Inositol phosphate metabolism_Homo sapiens_hsa005620.30549573
151Melanogenesis_Homo sapiens_hsa049160.29853862
152Proteoglycans in cancer_Homo sapiens_hsa052050.29480905
153cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28715030
154ErbB signaling pathway_Homo sapiens_hsa040120.27688750
155Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26458435
156Glioma_Homo sapiens_hsa052140.26139415
157Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25796552
158Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21709230
159Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21623889
160* Pathways in cancer_Homo sapiens_hsa052000.21593860
161Thyroid hormone synthesis_Homo sapiens_hsa049180.21217859
162Melanoma_Homo sapiens_hsa052180.20176255

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