PIAS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)7.97292606
2retinal rod cell development (GO:0046548)7.53702574
3rhodopsin mediated signaling pathway (GO:0016056)7.53081188
4polyketide metabolic process (GO:0030638)7.25853553
5doxorubicin metabolic process (GO:0044598)7.25853553
6daunorubicin metabolic process (GO:0044597)7.25853553
7photoreceptor cell development (GO:0042461)6.90829503
8eye photoreceptor cell development (GO:0042462)6.62066121
9photoreceptor cell maintenance (GO:0045494)6.40526623
10retinal cone cell development (GO:0046549)5.66364108
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.52581222
12GMP metabolic process (GO:0046037)5.14960413
13phototransduction (GO:0007602)4.89345217
14phototransduction, visible light (GO:0007603)4.71627209
15maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.56921663
16detection of light stimulus (GO:0009583)4.56810178
17protein retention in ER lumen (GO:0006621)4.52932771
18tooth mineralization (GO:0034505)4.37280284
19eye photoreceptor cell differentiation (GO:0001754)4.35518742
20photoreceptor cell differentiation (GO:0046530)4.35518742
21aminoglycoside antibiotic metabolic process (GO:0030647)4.33273278
22detection of visible light (GO:0009584)4.31965720
23Golgi transport vesicle coating (GO:0048200)4.05402936
24COPI coating of Golgi vesicle (GO:0048205)4.05402936
25visual perception (GO:0007601)4.04477929
26sensory perception of light stimulus (GO:0050953)4.03346488
27dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.98316145
28peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.98090318
29positive regulation of transcription regulatory region DNA binding (GO:2000679)3.96105182
30hemidesmosome assembly (GO:0031581)3.71291626
31axonemal dynein complex assembly (GO:0070286)3.69572606
32retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.69448347
33cortical actin cytoskeleton organization (GO:0030866)3.67616086
34epithelial cell fate commitment (GO:0072148)3.62850550
35negative regulation of fatty acid transport (GO:2000192)3.58352475
36retina development in camera-type eye (GO:0060041)3.53525368
37detection of light stimulus involved in sensory perception (GO:0050962)3.52495377
38detection of light stimulus involved in visual perception (GO:0050908)3.52495377
39positive regulation of guanylate cyclase activity (GO:0031284)3.50642897
40adherens junction assembly (GO:0034333)3.50568729
41semaphorin-plexin signaling pathway (GO:0071526)3.46564530
42negative regulation of chondrocyte differentiation (GO:0032331)3.42091524
43establishment of apical/basal cell polarity (GO:0035089)3.41647898
44cell-substrate junction assembly (GO:0007044)3.41484316
45positive regulation of blood vessel endothelial cell migration (GO:0043536)3.37707700
46focal adhesion assembly (GO:0048041)3.37179447
47cell-substrate adherens junction assembly (GO:0007045)3.37179447
48cytokinetic process (GO:0032506)3.35992955
49epithelial cell-cell adhesion (GO:0090136)3.32599575
50type B pancreatic cell development (GO:0003323)3.30275058
51regulation of beta-amyloid formation (GO:1902003)3.24701269
52adaptation of signaling pathway (GO:0023058)3.22809066
53cytoplasmic mRNA processing body assembly (GO:0033962)3.20816944
54skin morphogenesis (GO:0043589)3.20356747
55cortical cytoskeleton organization (GO:0030865)3.13477252
56kidney mesenchyme development (GO:0072074)3.11601377
57motile cilium assembly (GO:0044458)3.11529568
58L-fucose catabolic process (GO:0042355)3.08951682
59fucose catabolic process (GO:0019317)3.08951682
60L-fucose metabolic process (GO:0042354)3.08951682
61glandular epithelial cell development (GO:0002068)3.08139975
62cellular response to prostaglandin stimulus (GO:0071379)3.07136481
63muscle cell migration (GO:0014812)3.07097448
64Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.06902215
65atrioventricular valve morphogenesis (GO:0003181)3.05856400
66establishment of planar polarity (GO:0001736)3.04986037
67establishment of tissue polarity (GO:0007164)3.04986037
68substrate-dependent cell migration (GO:0006929)3.04241418
69detection of external stimulus (GO:0009581)3.00952004
70ear development (GO:0043583)2.98597607
71cilium or flagellum-dependent cell motility (GO:0001539)2.98281452
72negative regulation of embryonic development (GO:0045992)2.96214281
73post-embryonic morphogenesis (GO:0009886)2.95488927
74vascular endothelial growth factor signaling pathway (GO:0038084)2.95033738
75metanephric mesenchyme development (GO:0072075)2.94965999
76outer ear morphogenesis (GO:0042473)2.94919432
77regulation of establishment of planar polarity (GO:0090175)2.94829521
78negative regulation of cell size (GO:0045792)2.93953646
79detection of abiotic stimulus (GO:0009582)2.93537841
80regulation of guanylate cyclase activity (GO:0031282)2.93490489
81negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.93268227
82negative regulation of catenin import into nucleus (GO:0035414)2.93070950
83retina layer formation (GO:0010842)2.91582074
84regulation of amyloid precursor protein catabolic process (GO:1902991)2.89322178
85NLS-bearing protein import into nucleus (GO:0006607)2.88189411
86planar cell polarity pathway involved in neural tube closure (GO:0090179)2.87382204
87basement membrane organization (GO:0071711)2.86132022
88regulation of cardioblast differentiation (GO:0051890)2.86054446
89peptidyl-arginine omega-N-methylation (GO:0035247)2.85221330
90DNA dealkylation (GO:0035510)2.83848660
91COPII vesicle coating (GO:0048208)2.81952876
92regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.80725635
93hippo signaling (GO:0035329)2.76907721
94cellular response to light stimulus (GO:0071482)2.76762308
95receptor guanylyl cyclase signaling pathway (GO:0007168)2.75897586
96nuclear envelope reassembly (GO:0031468)2.75300352
97mitotic nuclear envelope reassembly (GO:0007084)2.75300352
98branching involved in mammary gland duct morphogenesis (GO:0060444)2.74978953
99regulation of type B pancreatic cell apoptotic process (GO:2000674)2.74419559
100apical protein localization (GO:0045176)2.74178956
101negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.73763222
102extracellular fibril organization (GO:0043206)2.72597332
103establishment of monopolar cell polarity (GO:0061162)2.70864135
104establishment or maintenance of monopolar cell polarity (GO:0061339)2.70864135
105regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.70460753
106glandular epithelial cell differentiation (GO:0002067)2.69348213
107bone trabecula formation (GO:0060346)2.69089942
108endothelial cell chemotaxis (GO:0035767)2.67984828
109vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.66834633
110negative regulation of cartilage development (GO:0061037)2.66233064
111paraxial mesoderm development (GO:0048339)2.64817762
112regulation of axon extension involved in axon guidance (GO:0048841)2.64736478
113barbed-end actin filament capping (GO:0051016)2.64727497
114positive regulation of hormone biosynthetic process (GO:0046886)2.63917893
115peptidyl-proline hydroxylation (GO:0019511)2.62986675
116face development (GO:0060324)2.62742984
117outflow tract septum morphogenesis (GO:0003148)2.62425008
118peptidyl-arginine methylation (GO:0018216)2.62294379
119peptidyl-arginine N-methylation (GO:0035246)2.62294379
120convergent extension (GO:0060026)2.62034846
121maternal placenta development (GO:0001893)2.61975496
122membrane budding (GO:0006900)2.59752269
123polarized epithelial cell differentiation (GO:0030859)2.58386991
124cilium movement (GO:0003341)2.58194983
125peptidyl-tyrosine autophosphorylation (GO:0038083)2.58149265
126regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.57974830
127response to pheromone (GO:0019236)2.55768460
128chondroitin sulfate catabolic process (GO:0030207)2.55472025
129glucocorticoid receptor signaling pathway (GO:0042921)2.54880223
130regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.53378245
131cochlea morphogenesis (GO:0090103)2.52490369
132vesicle coating (GO:0006901)2.51709107
133embryonic camera-type eye development (GO:0031076)2.51630415
134gland morphogenesis (GO:0022612)2.50744641
135ganglion development (GO:0061548)2.50720496
136embryonic eye morphogenesis (GO:0048048)2.49782224
137type B pancreatic cell proliferation (GO:0044342)2.49310986
138activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.49205335
139localization within membrane (GO:0051668)2.49109646
140regulation of water loss via skin (GO:0033561)2.48208495
141axon extension involved in axon guidance (GO:0048846)2.47607887
142neuron projection extension involved in neuron projection guidance (GO:1902284)2.47607887
143dermatan sulfate metabolic process (GO:0030205)2.47330335
144positive regulation of endothelial cell migration (GO:0010595)2.47314126
145regulation of mammary gland epithelial cell proliferation (GO:0033599)2.46741579
146response to prostaglandin E (GO:0034695)2.46321580
147negative regulation of axon extension involved in axon guidance (GO:0048843)2.46162230
148protein heterotrimerization (GO:0070208)2.45496465
149proline biosynthetic process (GO:0006561)2.44985570
150regulation of cGMP metabolic process (GO:0030823)2.44501480
151adherens junction organization (GO:0034332)2.43701033
152layer formation in cerebral cortex (GO:0021819)2.42724852
153endothelial cell morphogenesis (GO:0001886)2.42664921
154facial nerve structural organization (GO:0021612)2.42443643
155chondrocyte proliferation (GO:0035988)2.41168325
156positive regulation of Cdc42 GTPase activity (GO:0043089)2.41135212
157protein maturation by protein folding (GO:0022417)2.40905172
158cellular response to vitamin D (GO:0071305)2.40673126
159neuron development (GO:0048666)2.39963424
160glomerular basement membrane development (GO:0032836)2.39811742
161regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.39254163
162positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.38938244
163asymmetric protein localization (GO:0008105)2.38710770
164positive regulation of nuclease activity (GO:0032075)2.38086390
165negative regulation of osteoblast proliferation (GO:0033689)2.37847812
166endoplasmic reticulum unfolded protein response (GO:0030968)2.37719654
167cell adhesion mediated by integrin (GO:0033627)2.36495604
168positive regulation of gastrulation (GO:2000543)2.35297807
169regulation of cell proliferation involved in kidney development (GO:1901722)2.34573853
170morphogenesis of embryonic epithelium (GO:0016331)2.32850541
171positive regulation of vesicle fusion (GO:0031340)2.31528513
172prenylation (GO:0097354)2.31469454
173protein prenylation (GO:0018342)2.31469454
174regulation of calcium ion-dependent exocytosis (GO:0017158)2.30544136
175primitive streak formation (GO:0090009)2.30373516
176collagen fibril organization (GO:0030199)2.30115700
177body morphogenesis (GO:0010171)2.29470062
178cytoskeletal anchoring at plasma membrane (GO:0007016)2.29042553
179cellular senescence (GO:0090398)2.28754131
180regulation of cellular senescence (GO:2000772)2.26915970
181limb development (GO:0060173)2.25473776
182appendage development (GO:0048736)2.25473776
183nonmotile primary cilium assembly (GO:0035058)2.25357063
184positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.23925937
185mannose metabolic process (GO:0006013)2.23816458
186astrocyte differentiation (GO:0048708)2.22227141
187desmosome organization (GO:0002934)2.20820417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.51432609
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.91177893
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.77261281
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.29658277
5HIF1A_21447827_ChIP-Seq_MCF-7_Human3.11623902
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.10715542
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.05062551
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.04676914
9GATA1_22025678_ChIP-Seq_K562_Human2.83124292
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.54025385
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.54025385
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.54025385
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.48793152
14ZNF263_19887448_ChIP-Seq_K562_Human2.33929069
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.33890833
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.32869697
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.16575253
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.15803040
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.15653413
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.15306832
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.14623104
22* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.11036831
23MYC_22102868_ChIP-Seq_BL_Human2.09129239
24* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.00908538
25SCL_19346495_ChIP-Seq_HPC-7_Human1.91578183
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89651115
27* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87402775
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77911743
29VDR_21846776_ChIP-Seq_THP-1_Human1.77507641
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.76114257
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.71960288
32NFIB_24661679_ChIP-Seq_LUNG_Mouse1.71546539
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71006764
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68414379
35KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.66628780
36* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66134043
37KDM2B_26808549_Chip-Seq_DND41_Human1.66009281
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.65576143
39LXR_22292898_ChIP-Seq_THP-1_Human1.64500965
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.64273013
41KDM2B_26808549_Chip-Seq_K562_Human1.62629687
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.62232700
43CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.61952890
44TCF7_22412390_ChIP-Seq_EML_Mouse1.60566900
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.54147574
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53289338
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52977418
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51219423
49* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.48372796
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.47607642
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46845310
52TBX20_22080862_ChIP-Seq_HEART_Mouse1.46055848
53TBX20_22328084_ChIP-Seq_HEART_Mouse1.46055848
54CLOCK_20551151_ChIP-Seq_293T_Human1.45719517
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44999468
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43691476
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43319730
58ATF3_27146783_Chip-Seq_COLON_Human1.43314335
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42492949
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41196402
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37292767
62SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36413973
63SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36413973
64ISL1_27105846_Chip-Seq_CPCs_Mouse1.35851253
65FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.35184668
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34226697
67* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32537646
68* KDM2B_26808549_Chip-Seq_JURKAT_Human1.31722831
69GATA1_19941826_ChIP-Seq_K562_Human1.31534941
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30136825
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30020387
72CREB1_26743006_Chip-Seq_LNCaP_Human1.29498376
73* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27804844
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.26035604
75VDR_24763502_ChIP-Seq_THP-1_Human1.25991896
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25594552
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25384743
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24916963
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22484229
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.22058856
81TET1_21490601_ChIP-Seq_MESCs_Mouse1.19563801
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17794334
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17004741
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15952287
85AR_21909140_ChIP-Seq_LNCAP_Human1.15718802
86TP63_22573176_ChIP-Seq_HFKS_Human1.13204275
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12313345
88TP53_20018659_ChIP-ChIP_R1E_Mouse1.10860251
89EOMES_21245162_ChIP-Seq_HESCs_Human1.09874075
90FOXM1_23109430_ChIP-Seq_U2OS_Human1.09304152
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.09094474
92* GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.08559130
93ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07343982
94GATA3_24758297_ChIP-Seq_MCF-7_Human1.07102675
95* SMC4_20622854_ChIP-Seq_HELA_Human1.06999618
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06888325
97TP53_23651856_ChIP-Seq_MEFs_Mouse1.06738235
98OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06229503
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06160031
100KLF5_25053715_ChIP-Seq_YYC3_Human1.06131654
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05843815
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05499406
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05252960
104TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.04936619
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04668862
106* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04290345
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03277493
108AHR_22903824_ChIP-Seq_MCF-7_Human1.03214880
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02703414
110UBF1/2_26484160_Chip-Seq_HMECs_Human1.02479121
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01652167
112CIITA_25753668_ChIP-Seq_RAJI_Human1.01551600
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01377645
114* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01285607
115* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00452030
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00179992
117* RACK7_27058665_Chip-Seq_MCF-7_Human1.00055030
118CHD1_26751641_Chip-Seq_LNCaP_Human0.98404692
119EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98133719
120RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97678692
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96889706
122P68_20966046_ChIP-Seq_HELA_Human0.96347170
123SMAD_19615063_ChIP-ChIP_OVARY_Human0.95228249
124* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95103189
125SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94699098
126* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94543053
127TP53_22127205_ChIP-Seq_IMR90_Human0.94142839
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93958279
129* ESR2_21235772_ChIP-Seq_MCF-7_Human0.93350207
130SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92911066
131EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92594438
132P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92399031
133EP300_21415370_ChIP-Seq_HL-1_Mouse0.92251557
134MYB_26560356_Chip-Seq_TH1_Human0.92240621
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.90651668
136SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90627386
137* MAF_26560356_Chip-Seq_TH1_Human0.90309183
138GATA2_21666600_ChIP-Seq_HMVEC_Human0.89882215
139UTX_26944678_Chip-Seq_JUKART_Human0.89505486
140JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89251930
141SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.89144197
142SA1_27219007_Chip-Seq_ERYTHROID_Human0.89002152
143E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88814055
144* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88265567
145VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86224998
146KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85837895
147TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84776922
148DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84292579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog4.99251301
2MP0005670_abnormal_white_adipose4.44970101
3MP0003011_delayed_dark_adaptation4.24891728
4MP0006072_abnormal_retinal_apoptosis4.07269419
5MP0003183_abnormal_peptide_metabolism4.00213658
6MP0005253_abnormal_eye_physiology3.69931855
7MP0000013_abnormal_adipose_tissue3.61571469
8MP0008438_abnormal_cutaneous_collagen2.86684271
9MP0008961_abnormal_basal_metabolism2.47262800
10MP0005195_abnormal_posterior_eye2.36796624
11MP0002796_impaired_skin_barrier2.29578048
12MP0005391_vision/eye_phenotype2.24832572
13MP0000003_abnormal_adipose_tissue2.09368924
14MP0000579_abnormal_nail_morphology2.04897476
15MP0005275_abnormal_skin_tensile2.03101461
16MP0003279_aneurysm1.97174310
17MP0001958_emphysema1.94635772
18MP0001324_abnormal_eye_pigmentation1.94439748
19MP0005623_abnormal_meninges_morphology1.93159869
20MP0002653_abnormal_ependyma_morphology1.92728331
21MP0005503_abnormal_tendon_morphology1.92420267
22MP0005257_abnormal_intraocular_pressure1.91246097
23MP0003172_abnormal_lysosome_physiology1.89724659
24MP0002234_abnormal_pharynx_morphology1.88530619
25MP0010030_abnormal_orbit_morphology1.82722572
26MP0010234_abnormal_vibrissa_follicle1.72938239
27MP0000762_abnormal_tongue_morphology1.70208140
28MP0004272_abnormal_basement_membrane1.69931385
29MP0005375_adipose_tissue_phenotype1.65960115
30MP0005645_abnormal_hypothalamus_physiol1.65209430
31MP0003950_abnormal_plasma_membrane1.64289865
32MP0001502_abnormal_circadian_rhythm1.64169745
33MP0002249_abnormal_larynx_morphology1.56577402
34MP0005666_abnormal_adipose_tissue1.50772425
35MP0000467_abnormal_esophagus_morphology1.50661696
36MP0004858_abnormal_nervous_system1.44268121
37MP0000678_abnormal_parathyroid_gland1.41606679
38MP0005409_darkened_coat_color1.41570387
39MP0005076_abnormal_cell_differentiation1.41445181
40MP0002638_abnormal_pupillary_reflex1.40864206
41MP0008789_abnormal_olfactory_epithelium1.34427272
42MP0002138_abnormal_hepatobiliary_system1.34416204
43MP0001879_abnormal_lymphatic_vessel1.32695485
44MP0002877_abnormal_melanocyte_morpholog1.31734383
45MP0006292_abnormal_olfactory_placode1.29383495
46MP0003566_abnormal_cell_adhesion1.29317983
47MP0002108_abnormal_muscle_morphology1.26268547
48MP0003942_abnormal_urinary_system1.24994447
49MP0003283_abnormal_digestive_organ1.24544702
50MP0001299_abnormal_eye_distance/1.23853625
51MP0005083_abnormal_biliary_tract1.23299793
52MP0003705_abnormal_hypodermis_morpholog1.22957012
53MP0003091_abnormal_cell_migration1.22807362
54MP0001849_ear_inflammation1.20473559
55MP0003115_abnormal_respiratory_system1.19086758
56MP0002098_abnormal_vibrissa_morphology1.17001450
57MP0000428_abnormal_craniofacial_morphol1.16179401
58MP0003453_abnormal_keratinocyte_physiol1.15646960
59MP0003122_maternal_imprinting1.14047935
60MP0002177_abnormal_outer_ear1.13694539
61MP0005394_taste/olfaction_phenotype1.12595733
62MP0005499_abnormal_olfactory_system1.12595733
63MP0000462_abnormal_digestive_system1.12202441
64MP0000465_gastrointestinal_hemorrhage1.12024606
65MP0003119_abnormal_digestive_system1.11255382
66MP0003385_abnormal_body_wall1.10667751
67MP0008260_abnormal_autophagy1.09918117
68MP0002090_abnormal_vision1.09823111
69MP0001542_abnormal_bone_strength1.09620489
70MP0009384_cardiac_valve_regurgitation1.08522802
71MP0002896_abnormal_bone_mineralization1.07540863
72MP0003191_abnormal_cellular_cholesterol1.06977699
73MP0000383_abnormal_hair_follicle1.06779498
74MP0004885_abnormal_endolymph1.06048357
75MP0005367_renal/urinary_system_phenotyp1.05979993
76MP0000516_abnormal_urinary_system1.05979993
77MP0001346_abnormal_lacrimal_gland1.05321230
78MP0009053_abnormal_anal_canal1.04837382
79MP0010352_gastrointestinal_tract_polyps1.03778940
80MP0002752_abnormal_somatic_nervous1.03566495
81MP0000049_abnormal_middle_ear1.03404778
82MP0010678_abnormal_skin_adnexa1.02390764
83MP0010386_abnormal_urinary_bladder1.02137734
84MP0002229_neurodegeneration1.00444175
85MP0001216_abnormal_epidermal_layer1.00106701
86MP0002089_abnormal_postnatal_growth/wei0.99515905
87MP0004185_abnormal_adipocyte_glucose0.99206517
88MP0001286_abnormal_eye_development0.97815910
89MP0003941_abnormal_skin_development0.97682131
90MP0000566_synostosis0.95357893
91MP0006138_congestive_heart_failure0.95313412
92MP0005058_abnormal_lysosome_morphology0.95138499
93MP0003634_abnormal_glial_cell0.94791509
94MP0004782_abnormal_surfactant_physiolog0.92673805
95MP0009250_abnormal_appendicular_skeleto0.92374693
96MP0002282_abnormal_trachea_morphology0.92156655
97MP0010771_integument_phenotype0.90474803
98MP0001348_abnormal_lacrimal_gland0.89561123
99MP0000733_abnormal_muscle_development0.89449172
100MP0005220_abnormal_exocrine_pancreas0.87835717
101MP0008932_abnormal_embryonic_tissue0.87799470
102MP0005508_abnormal_skeleton_morphology0.87546436
103MP0002085_abnormal_embryonic_tissue0.87538207
104MP0002295_abnormal_pulmonary_circulatio0.86321004
105MP0001243_abnormal_dermal_layer0.85998017
106MP0000767_abnormal_smooth_muscle0.85419137
107MP0000432_abnormal_head_morphology0.85378289
108MP0006054_spinal_hemorrhage0.85322494
109MP0000537_abnormal_urethra_morphology0.85316447
110MP0000759_abnormal_skeletal_muscle0.83911483
111MP0000750_abnormal_muscle_regeneration0.83482513
112MP0001915_intracranial_hemorrhage0.83199420
113MP0004133_heterotaxia0.82779278
114MP0009931_abnormal_skin_appearance0.82478652
115MP0001764_abnormal_homeostasis0.82445256
116MP0005621_abnormal_cell_physiology0.81829494
117MP0001340_abnormal_eyelid_morphology0.79584518
118MP0000377_abnormal_hair_follicle0.79287166
119MP0000627_abnormal_mammary_gland0.79059267
120MP0005023_abnormal_wound_healing0.78969919
121MP0002092_abnormal_eye_morphology0.78609472
122MP0000534_abnormal_ureter_morphology0.78344755
123MP0004270_analgesia0.77670704
124MP0002128_abnormal_blood_circulation0.76692775
125MP0002925_abnormal_cardiovascular_devel0.76437122
126MP0009703_decreased_birth_body0.76362393
127MP0003755_abnormal_palate_morphology0.76307234
128MP0003943_abnormal_hepatobiliary_system0.75595965
129MP0009672_abnormal_birth_weight0.74992241
130MP0003123_paternal_imprinting0.74966151
131MP0005197_abnormal_uvea_morphology0.74153957
132MP0000538_abnormal_urinary_bladder0.73304542
133MP0002060_abnormal_skin_morphology0.73174261
134MP0002882_abnormal_neuron_morphology0.72187463
135MP0004087_abnormal_muscle_fiber0.71700227
136MP0000749_muscle_degeneration0.71213501
137MP0002080_prenatal_lethality0.70454495
138MP0005501_abnormal_skin_physiology0.69929765
139MP0004264_abnormal_extraembryonic_tissu0.69895381
140MP0002127_abnormal_cardiovascular_syste0.68164913
141MP0002837_dystrophic_cardiac_calcinosis0.67595428
142MP0002938_white_spotting0.66661118
143MP0002697_abnormal_eye_size0.66305249
144MP0004084_abnormal_cardiac_muscle0.65828290
145MP0002254_reproductive_system_inflammat0.65373531
146MP0001293_anophthalmia0.64699872
147MP0000751_myopathy0.64337952
148MP0003045_fibrosis0.63803449
149MP0002932_abnormal_joint_morphology0.63526069
150MP0004233_abnormal_muscle_weight0.61794869
151MP0000163_abnormal_cartilage_morphology0.61591912
152MP0010368_abnormal_lymphatic_system0.61195969
153MP0009780_abnormal_chondrocyte_physiolo0.60968678
154MP0003935_abnormal_craniofacial_develop0.60263445
155MP0002116_abnormal_craniofacial_bone0.60086355
156MP0002233_abnormal_nose_morphology0.56558799
157MP0010630_abnormal_cardiac_muscle0.56407554

Predicted human phenotypes

RankGene SetZ-score
1Pigmentary retinal degeneration (HP:0001146)8.58233952
2Absent rod-and cone-mediated responses on ERG (HP:0007688)8.12523701
3Congenital stationary night blindness (HP:0007642)7.65453405
4Abnormal rod and cone electroretinograms (HP:0008323)7.55768208
5Chorioretinal atrophy (HP:0000533)7.50139578
6Bony spicule pigmentary retinopathy (HP:0007737)6.97514919
7Abolished electroretinogram (ERG) (HP:0000550)5.89823884
8Pendular nystagmus (HP:0012043)5.67653715
9Central scotoma (HP:0000603)5.53735293
10Retinal atrophy (HP:0001105)5.11852395
11Scotoma (HP:0000575)4.81081449
12Increased corneal curvature (HP:0100692)4.47395069
13Keratoconus (HP:0000563)4.47395069
14Type II diabetes mellitus (HP:0005978)4.38364059
15Broad face (HP:0000283)4.13254511
16Posterior subcapsular cataract (HP:0007787)3.88550776
17Vitreoretinal degeneration (HP:0000655)3.77889707
18Attenuation of retinal blood vessels (HP:0007843)3.71323947
19Cervical subluxation (HP:0003308)3.58478129
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.52531311
21Photophobia (HP:0000613)3.50921576
22Atrophic scars (HP:0001075)3.44569835
23Dyschromatopsia (HP:0007641)3.36171546
24Macular degeneration (HP:0000608)3.30364890
25Vascular tortuosity (HP:0004948)3.26329771
26Abnormality of macular pigmentation (HP:0008002)3.17866992
27Severe visual impairment (HP:0001141)3.17669211
28Constricted visual fields (HP:0001133)3.16447924
29Arterial tortuosity (HP:0005116)3.15647657
30Premature rupture of membranes (HP:0001788)3.12678045
31Absent frontal sinuses (HP:0002688)3.05172825
32Decreased central vision (HP:0007663)2.97582192
33Cone-rod dystrophy (HP:0000548)2.90217576
34Fragile skin (HP:0001030)2.88132946
35Retinitis pigmentosa (HP:0000510)2.87857193
36Upper limb amyotrophy (HP:0009129)2.87417665
37Distal upper limb amyotrophy (HP:0007149)2.87417665
38Mildly elevated creatine phosphokinase (HP:0008180)2.83885245
39Hypoglycemic seizures (HP:0002173)2.82577374
40Spinal rigidity (HP:0003306)2.78889229
41Pancreatic islet-cell hyperplasia (HP:0004510)2.77060207
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.73428873
43Protrusio acetabuli (HP:0003179)2.70719336
44Hand muscle atrophy (HP:0009130)2.66307331
45Abnormal respiratory motile cilium physiology (HP:0012261)2.66123183
46Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.59560557
47J-shaped sella turcica (HP:0002680)2.59418106
48Papilledema (HP:0001085)2.54270565
49Rhinitis (HP:0012384)2.51265016
50Biconcave vertebral bodies (HP:0004586)2.47895259
51Chronic bronchitis (HP:0004469)2.44731975
52Aortic aneurysm (HP:0004942)2.44510605
53Abnormality of the umbilical cord (HP:0010881)2.42577213
54Abnormal respiratory epithelium morphology (HP:0012253)2.42005886
55Abnormal respiratory motile cilium morphology (HP:0005938)2.42005886
56Pterygium (HP:0001059)2.39736456
57Hyperinsulinemic hypoglycemia (HP:0000825)2.39146910
58Microglossia (HP:0000171)2.39054897
59Soft skin (HP:0000977)2.37710114
60Progressive visual loss (HP:0000529)2.34634614
61Hyperacusis (HP:0010780)2.33000023
62Short nail (HP:0001799)2.32536446
63Choroideremia (HP:0001139)2.30590106
64Vertebral compression fractures (HP:0002953)2.29303189
65Abnormal ciliary motility (HP:0012262)2.29138896
66Overgrowth (HP:0001548)2.25320854
67Abnormality of the distal phalanges of the toes (HP:0010182)2.23719107
68Breech presentation (HP:0001623)2.22818183
69Atelectasis (HP:0100750)2.21550658
70Shallow orbits (HP:0000586)2.19234389
71Joint laxity (HP:0001388)2.17188215
72Increased connective tissue (HP:0009025)2.16925879
73Obstructive sleep apnea (HP:0002870)2.15692821
74Cerebral aneurysm (HP:0004944)2.14186296
75Bell-shaped thorax (HP:0001591)2.14164820
76Dysostosis multiplex (HP:0000943)2.12795170
77Advanced eruption of teeth (HP:0006288)2.12010493
78Stridor (HP:0010307)2.10156767
79Distal lower limb amyotrophy (HP:0008944)2.08747600
80Abnormality of dentin (HP:0010299)2.08244984
81Asymmetry of the thorax (HP:0001555)2.04556363
82Natal tooth (HP:0000695)2.03690365
83Genu recurvatum (HP:0002816)2.02284514
84Abnormality of the frontal sinuses (HP:0002687)2.02211036
85Long toe (HP:0010511)2.02041843
86Dynein arm defect of respiratory motile cilia (HP:0012255)2.01565672
87Absent/shortened dynein arms (HP:0200106)2.01565672
88Flat acetabular roof (HP:0003180)1.99980250
89Wide nasal bridge (HP:0000431)1.99570051
90Wormian bones (HP:0002645)1.94999742
91Spinal cord lesions (HP:0100561)1.94362105
92Syringomyelia (HP:0003396)1.94362105
93Round ear (HP:0100830)1.93522724
94Aortic regurgitation (HP:0001659)1.93325962
95Selective tooth agenesis (HP:0001592)1.92647404
96Broad metatarsal (HP:0001783)1.91835365
97Abnormality of the pancreatic islet cells (HP:0006476)1.91215409
98Abnormality of endocrine pancreas physiology (HP:0012093)1.91215409
99Ankle contracture (HP:0006466)1.91127385
100Lip pit (HP:0100267)1.90978376
101Dilatation of the ascending aorta (HP:0005111)1.90885229
102Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.89965616
103Large for gestational age (HP:0001520)1.88977474
104Congenital sensorineural hearing impairment (HP:0008527)1.86338906
105Symptomatic seizures (HP:0011145)1.86247069
106Macroorchidism (HP:0000053)1.85734939
107Abnormal delivery (HP:0001787)1.84946451
108Aplasia of the musculature (HP:0100854)1.84576151
109Achilles tendon contracture (HP:0001771)1.83875511
110Thin bony cortex (HP:0002753)1.83743155
111Short clavicles (HP:0000894)1.82242032
112Abnormality of skeletal muscle fiber size (HP:0012084)1.81938636
113Bowel diverticulosis (HP:0005222)1.81629016
114Generalized amyotrophy (HP:0003700)1.81505422
115Flared iliac wings (HP:0002869)1.81200181
116Neonatal short-limb short stature (HP:0008921)1.79989705
117Glucose intolerance (HP:0000833)1.79309244
118Subcapsular cataract (HP:0000523)1.78814253
119Premature skin wrinkling (HP:0100678)1.77600606
120Aortic dissection (HP:0002647)1.77361035
121Follicular hyperkeratosis (HP:0007502)1.76273321
122Amelogenesis imperfecta (HP:0000705)1.76154273
123Bladder diverticulum (HP:0000015)1.75495835
124Right ventricular cardiomyopathy (HP:0011663)1.75102952
125Mitral regurgitation (HP:0001653)1.73240850
126Male infertility (HP:0003251)1.72292390
127Lymphangioma (HP:0100764)1.72145379
128Abnormality of the acetabulum (HP:0003170)1.71577774
129Arnold-Chiari malformation (HP:0002308)1.68757211
130Thin ribs (HP:0000883)1.68625353
131Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68427483
132Abnormality of calcium-phosphate metabolism (HP:0100530)1.67839334
133Flattened epiphyses (HP:0003071)1.67650022
134Osteolytic defects of the phalanges of the hand (HP:0009771)1.67268796
135Osteolytic defects of the hand bones (HP:0009699)1.67268796
136Increased neuronal autofluorescent lipopigment (HP:0002074)1.67007222
137Nasal polyposis (HP:0100582)1.66099666
138Lower limb amyotrophy (HP:0007210)1.66072306
139Interstitial pulmonary disease (HP:0006530)1.65992933
140Trismus (HP:0000211)1.65747729
141Bronchomalacia (HP:0002780)1.65496246
142Joint stiffness (HP:0001387)1.64786887
143Urinary glycosaminoglycan excretion (HP:0003541)1.59787428
144Mucopolysacchariduria (HP:0008155)1.59787428
145Congenital glaucoma (HP:0001087)1.59679752
146Increased cerebral lipofuscin (HP:0011813)1.59578691
147Centrally nucleated skeletal muscle fibers (HP:0003687)1.55356405
148Humeroradial synostosis (HP:0003041)1.54623088
149Synostosis involving the elbow (HP:0003938)1.54623088
150Buphthalmos (HP:0000557)1.52974577
151Blue sclerae (HP:0000592)1.52348631
152Spondylolisthesis (HP:0003302)1.48840380
153Congenital primary aphakia (HP:0007707)1.48224138
154Increased variability in muscle fiber diameter (HP:0003557)1.45927817
155Ulnar bowing (HP:0003031)1.45196002
156Septo-optic dysplasia (HP:0100842)1.43900871
157Aplasia/Hypoplasia of the lens (HP:0008063)1.42814819
158Peritonitis (HP:0002586)1.42486521
159Hypoplasia of the odontoid process (HP:0003311)1.42050102
160Molar tooth sign on MRI (HP:0002419)1.41615477
161Abnormality of midbrain morphology (HP:0002418)1.41615477
162Distal lower limb muscle weakness (HP:0009053)1.39860981
163Late onset (HP:0003584)1.39305301
164Elbow flexion contracture (HP:0002987)1.38934893
165Gait imbalance (HP:0002141)1.38792098
166Abnormality of the fetal cardiovascular system (HP:0010948)1.37147622
167Abnormal umbilical cord blood vessels (HP:0011403)1.37147622
168Single umbilical artery (HP:0001195)1.37147622
169Hyperparathyroidism (HP:0000843)1.36784557
170Renal duplication (HP:0000075)1.36773998
171Bowed forearm bones (HP:0003956)1.35769830
172Bowing of the arm (HP:0006488)1.35769830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.03181960
2TAOK33.63296042
3TESK13.47430877
4TRIB33.42465779
5SMG13.14511550
6PRKD32.42722210
7MAPK152.36554391
8PASK2.28077859
9CSNK1A1L2.22383697
10PKN22.09945390
11MAPKAPK32.09909321
12PTK62.07108792
13TLK11.88661057
14FLT31.86513937
15MST1R1.73420061
16MAP3K131.72180519
17HIPK21.70839213
18SCYL21.70816251
19LIMK11.67460536
20CSNK1G31.67343459
21NEK21.64947553
22TGFBR11.59227645
23MUSK1.57950661
24ERN11.56457895
25TTN1.55886427
26MYLK1.51225078
27KIT1.51144044
28SIK31.49889154
29MAP3K101.46357338
30RIPK11.44456607
31INSRR1.42507475
32BRD41.42253489
33NTRK11.42084805
34EPHB11.41634575
35RPS6KB21.41595613
36ARAF1.40788192
37WNK11.39496851
38VRK21.38497832
39DDR21.38356196
40KSR21.34648788
41MATK1.34356083
42GRK11.31232709
43TAOK21.30672447
44EPHB21.30357351
45PIK3CG1.28892765
46CSNK1G11.25319909
47UHMK11.25227026
48STK101.24834976
49DYRK1B1.23132361
50EEF2K1.21117527
51SIK11.19814474
52TGFBR21.19615518
53DMPK1.18409198
54NTRK21.17352046
55NEK91.15650161
56LRRK21.15636797
57PRKD21.15063160
58CLK11.14482085
59PBK1.11746682
60IRAK31.11168329
61ERBB41.09622646
62PRKCH1.08252380
63LATS21.05861179
64NME21.05176181
65MET1.02047318
66TESK21.00908493
67CAMKK10.99733279
68TIE10.98353042
69BMPR1B0.98201299
70TTK0.97605250
71PTK20.97179031
72CDC42BPA0.96392657
73LMTK20.95873790
74CDK120.95653010
75CAMK1G0.95241890
76STK380.95091775
77CSNK1G20.94952800
78ROCK20.94873644
79EIF2AK10.94127513
80PAK20.89865510
81FGFR40.87821806
82MAP2K30.87006729
83PAK30.85656458
84PRKD10.85462188
85TYK20.85281323
86MAP2K20.84958978
87BCR0.84679373
88NEK60.84587682
89MAP3K60.83866816
90ICK0.83725897
91LATS10.82988205
92CHUK0.82033808
93TBK10.82015857
94ACVR1B0.78526359
95MAP2K10.78346484
96RPS6KA20.77624544
97PAK40.77102798
98ADRBK10.75130005
99MAP3K120.69665440
100SGK2230.69343217
101SGK4940.69343217
102MAP3K30.69089726
103MAPKAPK20.68130583
104CDK90.67903245
105ILK0.66863573
106MARK20.65065778
107JAK30.63554166
108PDGFRA0.62449254
109MOS0.61100547
110ROCK10.58648061
111BRAF0.57872902
112PRPF4B0.57517099
113PDGFRB0.56909607
114EPHA30.55784705
115MAP3K70.55712350
116BRSK10.53836622
117CDK80.52502918
118TRIM280.52489274
119CSNK1D0.51816344
120STK30.51667512
121BUB10.51030051
122RET0.50916564
123NME10.50858397
124MELK0.49356340
125CAMK2G0.48650441
126PIK3CA0.48533961
127ERBB20.46883485
128SRC0.44955001
129PKN10.44312061
130BMX0.44294845
131CSK0.43653288
132FER0.43457235
133TRPM70.43107592
134CDK60.42093583
135STK38L0.41982602
136PTK2B0.41935767
137WNK40.41488315
138PRKCI0.40685929
139MAPK10.40066040
140TAOK10.39364903
141CDK70.37688351
142PIM20.37646654
143AURKA0.36172045
144MAPK90.36024125
145RPS6KL10.35611734
146RPS6KC10.35611734
147FYN0.35325233
148MTOR0.35258553
149ERBB30.34496368
150MAP3K10.33769245
151YES10.33436721
152RPS6KA60.32683743
153KDR0.31068006
154FGFR10.30283227

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047449.17738639
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.53623639
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.55632601
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.36226503
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.65369818
6Pentose phosphate pathway_Homo sapiens_hsa000301.44110360
7ECM-receptor interaction_Homo sapiens_hsa045121.37441961
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36518466
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.36466471
10N-Glycan biosynthesis_Homo sapiens_hsa005101.35586630
11Fructose and mannose metabolism_Homo sapiens_hsa000511.32659209
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26106665
13Longevity regulating pathway - mammal_Homo sapiens_hsa042111.22144692
14Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.20871189
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20648341
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14600040
17Regulation of actin cytoskeleton_Homo sapiens_hsa048101.13607191
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13142980
19Focal adhesion_Homo sapiens_hsa045101.09988234
20Axon guidance_Homo sapiens_hsa043601.08345300
21Estrogen signaling pathway_Homo sapiens_hsa049151.07902316
22Sulfur relay system_Homo sapiens_hsa041221.07277978
23Gap junction_Homo sapiens_hsa045401.04009224
24Hedgehog signaling pathway_Homo sapiens_hsa043401.00991212
25Hippo signaling pathway_Homo sapiens_hsa043901.00839403
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00780107
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00021844
28Wnt signaling pathway_Homo sapiens_hsa043100.99860546
29AMPK signaling pathway_Homo sapiens_hsa041520.97882873
30Biosynthesis of amino acids_Homo sapiens_hsa012300.96223112
31VEGF signaling pathway_Homo sapiens_hsa043700.95086142
32mTOR signaling pathway_Homo sapiens_hsa041500.94942282
33Dilated cardiomyopathy_Homo sapiens_hsa054140.94388235
34Lysine degradation_Homo sapiens_hsa003100.93531040
35B cell receptor signaling pathway_Homo sapiens_hsa046620.93068995
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92111075
37Phenylalanine metabolism_Homo sapiens_hsa003600.91659481
38Insulin signaling pathway_Homo sapiens_hsa049100.91431421
39Viral myocarditis_Homo sapiens_hsa054160.90585268
40Cholinergic synapse_Homo sapiens_hsa047250.88957816
41Notch signaling pathway_Homo sapiens_hsa043300.88538603
42Thyroid cancer_Homo sapiens_hsa052160.88000895
43Glutathione metabolism_Homo sapiens_hsa004800.87849259
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87218668
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85999533
46Proteoglycans in cancer_Homo sapiens_hsa052050.85867344
47Small cell lung cancer_Homo sapiens_hsa052220.85667826
48Olfactory transduction_Homo sapiens_hsa047400.85114957
49TGF-beta signaling pathway_Homo sapiens_hsa043500.85016718
50Base excision repair_Homo sapiens_hsa034100.84475706
51Melanogenesis_Homo sapiens_hsa049160.84108434
52Basal cell carcinoma_Homo sapiens_hsa052170.83535299
53Insulin secretion_Homo sapiens_hsa049110.83364806
54Other glycan degradation_Homo sapiens_hsa005110.83355105
55Acute myeloid leukemia_Homo sapiens_hsa052210.83327688
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81311883
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79947477
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79681657
59Lysosome_Homo sapiens_hsa041420.78688484
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77019608
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75803810
62Steroid biosynthesis_Homo sapiens_hsa001000.75346152
63Gastric acid secretion_Homo sapiens_hsa049710.74831349
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74738413
65Choline metabolism in cancer_Homo sapiens_hsa052310.73798665
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73771241
67Adherens junction_Homo sapiens_hsa045200.72019734
68Bladder cancer_Homo sapiens_hsa052190.71934725
69PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71249572
70Endocytosis_Homo sapiens_hsa041440.69521362
71Pathways in cancer_Homo sapiens_hsa052000.69219540
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.69198577
73Protein digestion and absorption_Homo sapiens_hsa049740.67728337
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67647366
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67380131
76Type II diabetes mellitus_Homo sapiens_hsa049300.66912199
77Chronic myeloid leukemia_Homo sapiens_hsa052200.66590165
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65971811
79Galactose metabolism_Homo sapiens_hsa000520.65161157
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64060711
81Protein export_Homo sapiens_hsa030600.64023485
82Vibrio cholerae infection_Homo sapiens_hsa051100.62441456
83mRNA surveillance pathway_Homo sapiens_hsa030150.62254643
84Circadian entrainment_Homo sapiens_hsa047130.62039842
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.61870046
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61606366
87Carbon metabolism_Homo sapiens_hsa012000.61388369
88Thyroid hormone synthesis_Homo sapiens_hsa049180.61148354
89Prostate cancer_Homo sapiens_hsa052150.61016229
90Insulin resistance_Homo sapiens_hsa049310.60659840
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60607602
92Hepatitis C_Homo sapiens_hsa051600.60471659
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.60402855
94Tight junction_Homo sapiens_hsa045300.59718985
95Long-term depression_Homo sapiens_hsa047300.59166426
96HTLV-I infection_Homo sapiens_hsa051660.57247677
97Toxoplasmosis_Homo sapiens_hsa051450.56826089
98Circadian rhythm_Homo sapiens_hsa047100.56247004
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56116376
100Fatty acid elongation_Homo sapiens_hsa000620.55842608
101MicroRNAs in cancer_Homo sapiens_hsa052060.55322424
102Ras signaling pathway_Homo sapiens_hsa040140.54720719
103Cell cycle_Homo sapiens_hsa041100.54583776
104Prion diseases_Homo sapiens_hsa050200.53159180
105Inositol phosphate metabolism_Homo sapiens_hsa005620.52715197
106GnRH signaling pathway_Homo sapiens_hsa049120.50911862
107Pancreatic cancer_Homo sapiens_hsa052120.50892848
108Morphine addiction_Homo sapiens_hsa050320.50498881
109Sphingolipid metabolism_Homo sapiens_hsa006000.50089373
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49370504
111Chemokine signaling pathway_Homo sapiens_hsa040620.49249609
112Colorectal cancer_Homo sapiens_hsa052100.49074172
113Endometrial cancer_Homo sapiens_hsa052130.49011085
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48835068
115Renal cell carcinoma_Homo sapiens_hsa052110.48834817
116ErbB signaling pathway_Homo sapiens_hsa040120.48768861
117p53 signaling pathway_Homo sapiens_hsa041150.48488519
118GABAergic synapse_Homo sapiens_hsa047270.47904281
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.46417418
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.45550750
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45305395
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45203744
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44851041
124Pancreatic secretion_Homo sapiens_hsa049720.44667181
125Non-small cell lung cancer_Homo sapiens_hsa052230.44459264
126Amoebiasis_Homo sapiens_hsa051460.44281181
127Melanoma_Homo sapiens_hsa052180.44138334
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.44085144
129Glioma_Homo sapiens_hsa052140.44041207
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43767184
131Rap1 signaling pathway_Homo sapiens_hsa040150.43614126
132Oxytocin signaling pathway_Homo sapiens_hsa049210.42429597
133Cocaine addiction_Homo sapiens_hsa050300.42312554
134Apoptosis_Homo sapiens_hsa042100.41787387
135Nucleotide excision repair_Homo sapiens_hsa034200.40394528
136Dopaminergic synapse_Homo sapiens_hsa047280.40181032

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