PIAS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of telomere maintenance (GO:0032205)4.48380412
2motile cilium assembly (GO:0044458)4.29973145
3NIK/NF-kappaB signaling (GO:0038061)4.16980734
4histone H3-K4 trimethylation (GO:0080182)4.16186862
5regulation of chromatin binding (GO:0035561)4.09907499
6regulation of mammary gland epithelial cell proliferation (GO:0033599)4.05838431
7pyrimidine dimer repair (GO:0006290)4.00216627
8peptidyl-arginine omega-N-methylation (GO:0035247)3.99540863
9negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.98646604
103-UTR-mediated mRNA stabilization (GO:0070935)3.89590995
11nucleosome disassembly (GO:0006337)3.81724939
12protein-DNA complex disassembly (GO:0032986)3.81724939
13epithelial cilium movement (GO:0003351)3.76598259
14intracellular estrogen receptor signaling pathway (GO:0030520)3.75492844
15spliceosomal tri-snRNP complex assembly (GO:0000244)3.67522469
16negative regulation of DNA-templated transcription, elongation (GO:0032785)3.63700423
17regulation of nuclear cell cycle DNA replication (GO:0033262)3.62830029
18heterochromatin organization (GO:0070828)3.58943960
19photoreceptor cell maintenance (GO:0045494)3.58398224
20detection of light stimulus involved in sensory perception (GO:0050962)3.57493017
21detection of light stimulus involved in visual perception (GO:0050908)3.57493017
22negative regulation of erythrocyte differentiation (GO:0045647)3.56348426
23axonemal dynein complex assembly (GO:0070286)3.48862007
24histone arginine methylation (GO:0034969)3.48686502
25deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43511560
26pentose metabolic process (GO:0019321)3.41380656
27negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.40586544
28microtubule depolymerization (GO:0007019)3.39329824
29chromatin assembly (GO:0031497)3.33427569
30apoptotic process involved in morphogenesis (GO:0060561)3.31520437
31forebrain neuron differentiation (GO:0021879)3.29742172
32presynaptic membrane assembly (GO:0097105)3.26934680
33positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.25675110
34pentose-phosphate shunt (GO:0006098)3.25581498
35DNA deamination (GO:0045006)3.23931640
36regulation of telomere maintenance (GO:0032204)3.23396894
37cilium movement (GO:0003341)3.23369799
38protein insertion into membrane (GO:0051205)3.22350777
39modulation by virus of host process (GO:0019054)3.21559538
40nuclear envelope reassembly (GO:0031468)3.15076794
41mitotic nuclear envelope reassembly (GO:0007084)3.15076794
42presynaptic membrane organization (GO:0097090)3.12234540
43keratinocyte development (GO:0003334)3.11927491
44negative regulation of cell size (GO:0045792)3.09090055
45negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.09083482
46cilium or flagellum-dependent cell motility (GO:0001539)3.08929846
47neuron cell-cell adhesion (GO:0007158)3.07423032
48water-soluble vitamin biosynthetic process (GO:0042364)3.05801565
49startle response (GO:0001964)3.05039331
50positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.04292406
51Golgi transport vesicle coating (GO:0048200)3.03742234
52COPI coating of Golgi vesicle (GO:0048205)3.03742234
53DNA damage induced protein phosphorylation (GO:0006975)3.02302569
54viral mRNA export from host cell nucleus (GO:0046784)3.01648143
55peptidyl-arginine methylation (GO:0018216)3.01465491
56peptidyl-arginine N-methylation (GO:0035246)3.01465491
57negative regulation of telomerase activity (GO:0051974)2.99624870
58negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.97697570
59positive regulation of Cdc42 GTPase activity (GO:0043089)2.96811608
60proline biosynthetic process (GO:0006561)2.94925708
61glucose catabolic process (GO:0006007)2.94572213
62nonmotile primary cilium assembly (GO:0035058)2.92819857
63spinal cord motor neuron differentiation (GO:0021522)2.90874066
64planar cell polarity pathway involved in neural tube closure (GO:0090179)2.89884007
65regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.89851800
66DNA integration (GO:0015074)2.89469299
67regulation of rhodopsin mediated signaling pathway (GO:0022400)2.88000451
68protein maturation by protein folding (GO:0022417)2.87606912
69eye photoreceptor cell development (GO:0042462)2.86896487
70protein complex localization (GO:0031503)2.86509535
71central nervous system myelination (GO:0022010)2.85683779
72axon ensheathment in central nervous system (GO:0032291)2.85683779
73mitotic chromosome condensation (GO:0007076)2.85063355
74modulation by symbiont of host cellular process (GO:0044068)2.84996010
75maternal placenta development (GO:0001893)2.84832349
76negative regulation of necroptotic process (GO:0060546)2.82361803
77axoneme assembly (GO:0035082)2.80928016
78regulation of timing of cell differentiation (GO:0048505)2.80873714
79regulation of development, heterochronic (GO:0040034)2.77503011
80limb bud formation (GO:0060174)2.77110799
81rhodopsin mediated signaling pathway (GO:0016056)2.75143508
82epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.74423717
83regulation of translational termination (GO:0006449)2.73955966
84chromatin silencing (GO:0006342)2.73921384
85regulation of telomerase activity (GO:0051972)2.73305286
86post-embryonic morphogenesis (GO:0009886)2.73091882
87regulation of early endosome to late endosome transport (GO:2000641)2.72788850
88L-alpha-amino acid transmembrane transport (GO:1902475)2.70633612
89rRNA transcription (GO:0009303)2.70095965
90NADPH regeneration (GO:0006740)2.68913778
91regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.68532712
92DNA unwinding involved in DNA replication (GO:0006268)2.67667365
93cell proliferation in forebrain (GO:0021846)2.67210151
94long-chain fatty acid biosynthetic process (GO:0042759)2.66859815
95negative regulation of histone methylation (GO:0031061)2.66465520
96DNA methylation involved in gamete generation (GO:0043046)2.65840314
97photoreceptor cell development (GO:0042461)2.64750200
98preassembly of GPI anchor in ER membrane (GO:0016254)2.64680091
99histone H2B ubiquitination (GO:0033523)2.62793658
100histone H3-K4 methylation (GO:0051568)2.61887384
101negative regulation of execution phase of apoptosis (GO:1900118)2.60628096
102protein localization to endosome (GO:0036010)2.59676572
103negative regulation of mRNA metabolic process (GO:1903312)2.59046917
104negative regulation of DNA-dependent DNA replication (GO:2000104)2.58956900
105ribosomal small subunit biogenesis (GO:0042274)2.57651992
106multicellular organism reproduction (GO:0032504)2.57339163
107histone H3-K36 demethylation (GO:0070544)2.56772086
108oogenesis (GO:0048477)2.56446967
109organ growth (GO:0035265)2.56364287
110regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.55796719
111response to redox state (GO:0051775)2.55767889
112RNA stabilization (GO:0043489)2.54979008
113mRNA stabilization (GO:0048255)2.54979008
114retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54125132
115GPI anchor biosynthetic process (GO:0006506)2.53885083
116UV protection (GO:0009650)2.53368166
117activation of MAPKKK activity (GO:0000185)2.53201679
118snRNA metabolic process (GO:0016073)2.53158869
119proteasome assembly (GO:0043248)2.52894730
120sulfate transmembrane transport (GO:1902358)2.52656534
121negative regulation of mRNA processing (GO:0050686)2.52020537
122peptidyl-lysine trimethylation (GO:0018023)2.51686114
123adherens junction assembly (GO:0034333)2.50820072
124establishment of protein localization to mitochondrial membrane (GO:0090151)2.50737881
125positive regulation of action potential (GO:0045760)2.49975306
126cilium assembly (GO:0042384)2.49726684
127cellular response to virus (GO:0098586)2.49523347
128positive regulation of microtubule polymerization (GO:0031116)2.48767836
129GDP-mannose metabolic process (GO:0019673)2.47326870
130auditory receptor cell stereocilium organization (GO:0060088)2.46751621
131sulfate transport (GO:0008272)2.46661432
132regulation of NFAT protein import into nucleus (GO:0051532)2.45092193
133regulation of defense response to virus by virus (GO:0050690)2.44823123
134regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.44713637
135retina layer formation (GO:0010842)2.42558041
136retinal cone cell development (GO:0046549)2.42521377
137cilium organization (GO:0044782)2.42163847
138positive regulation of T cell apoptotic process (GO:0070234)2.40991194
139UTP biosynthetic process (GO:0006228)2.40554524
140signal complex assembly (GO:0007172)2.40028389
141piRNA metabolic process (GO:0034587)2.39647203
142ionotropic glutamate receptor signaling pathway (GO:0035235)2.39621835
143protein retention in ER lumen (GO:0006621)2.39499757
144transcription elongation from RNA polymerase I promoter (GO:0006362)2.38843871
145cell differentiation in spinal cord (GO:0021515)2.38507002
146GTP biosynthetic process (GO:0006183)2.38377622
147substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.37954010
148substrate-independent telencephalic tangential migration (GO:0021826)2.37954010
149regulation of meiosis I (GO:0060631)2.37428923
150protein polyglutamylation (GO:0018095)2.35556783
151DNA damage response, detection of DNA damage (GO:0042769)2.35485651
152viral protein processing (GO:0019082)2.35294142
153positive regulation of lymphocyte apoptotic process (GO:0070230)2.35036628
154single strand break repair (GO:0000012)2.34784503
155virion assembly (GO:0019068)2.34725607
156positive regulation of viral transcription (GO:0050434)2.34660236
157peptidyl-arginine modification (GO:0018195)2.34576750
158negative regulation of RNA splicing (GO:0033119)2.34376956
159positive regulation of interleukin-8 secretion (GO:2000484)2.34124602
160righting reflex (GO:0060013)2.34043178
161mRNA splice site selection (GO:0006376)2.33885625
162centriole assembly (GO:0098534)2.33867421
163microtubule polymerization or depolymerization (GO:0031109)2.33565065
164regulation of cilium movement (GO:0003352)2.33531133
165protein K6-linked ubiquitination (GO:0085020)2.33114484
166forebrain neuron development (GO:0021884)2.33017041
167RNA destabilization (GO:0050779)2.32165940
168positive regulation of gene expression, epigenetic (GO:0045815)2.31762321
169acrosome reaction (GO:0007340)2.31351764
170negative regulation of glial cell proliferation (GO:0060253)2.31234873
171modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.31018997
172positive regulation by organism of defense response of other organism involved in symbiotic interact2.31018997
173modulation by symbiont of host immune response (GO:0052553)2.31018997
174positive regulation by symbiont of host defense response (GO:0052509)2.31018997
175modulation by symbiont of host defense response (GO:0052031)2.31018997
176modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.31018997
177regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.30381767
178inner ear receptor stereocilium organization (GO:0060122)2.30283872
179negative regulation of response to food (GO:0032096)2.30091987
180negative regulation of appetite (GO:0032099)2.30091987
181positive regulation of meiosis (GO:0045836)2.29439941
182sperm motility (GO:0030317)2.29366577
183mitotic G1 DNA damage checkpoint (GO:0031571)2.28720190
184cellular protein complex localization (GO:0034629)2.28311300
185pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.27414311
186negative regulation of Ras GTPase activity (GO:0034261)2.27041144
187regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.26204415
188positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.26204415
189termination of RNA polymerase I transcription (GO:0006363)2.26001922
190iron-sulfur cluster assembly (GO:0016226)2.25842160
191metallo-sulfur cluster assembly (GO:0031163)2.25842160
192pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.25818237
193termination of RNA polymerase III transcription (GO:0006386)2.25793832
194transcription elongation from RNA polymerase III promoter (GO:0006385)2.25793832
195retina development in camera-type eye (GO:0060041)2.25428809
196GPI anchor metabolic process (GO:0006505)2.25286048
197postsynaptic membrane organization (GO:0001941)2.24651025
198pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.24588953
199developmental pigmentation (GO:0048066)2.22779728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.84985097
2GBX2_23144817_ChIP-Seq_PC3_Human3.65741102
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.06750568
4VDR_21846776_ChIP-Seq_THP-1_Human3.00985901
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.90707677
6MYC_22102868_ChIP-Seq_BL_Human2.73131036
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.71317718
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.59987020
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42346029
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39388570
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36351917
12LXR_22292898_ChIP-Seq_THP-1_Human2.33853339
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.30255729
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26849943
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.23600630
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.20089142
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17323980
18VDR_22108803_ChIP-Seq_LS180_Human2.15572939
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.10895844
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.06519176
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.02975619
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.00279169
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99474035
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.94573992
25* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.92956719
26E2F7_22180533_ChIP-Seq_HELA_Human1.90230859
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.86947041
28KDM2B_26808549_Chip-Seq_DND41_Human1.82893684
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.82129639
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78212349
31RACK7_27058665_Chip-Seq_MCF-7_Human1.78194024
32KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.76862939
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.76862939
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.76862939
35TCF7_22412390_ChIP-Seq_EML_Mouse1.75230766
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.75122970
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.74521301
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73910509
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71446279
40TAF15_26573619_Chip-Seq_HEK293_Human1.70786154
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.70769461
42* P68_20966046_ChIP-Seq_HELA_Human1.70490213
43XRN2_22483619_ChIP-Seq_HELA_Human1.68600893
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68414926
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68132932
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.67362252
47* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.67119536
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.65142203
49RNF2_27304074_Chip-Seq_NSC_Mouse1.65048898
50* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64470011
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61135984
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61100408
53FUS_26573619_Chip-Seq_HEK293_Human1.59554085
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.57902122
55* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56679475
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56155494
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54208189
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53236292
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51720829
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51416574
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.51074952
62MAF_26560356_Chip-Seq_TH1_Human1.49550044
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48720596
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48469604
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.48219771
66MAF_26560356_Chip-Seq_TH2_Human1.48132470
67UTX_26944678_Chip-Seq_JUKART_Human1.47652228
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47538813
69VDR_24763502_ChIP-Seq_THP-1_Human1.47223141
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.46981874
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46376930
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45677326
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43727709
74KDM2B_26808549_Chip-Seq_K562_Human1.42129530
75RNF2_27304074_Chip-Seq_ESCs_Mouse1.41000645
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.40700974
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40427630
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40205342
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.39986211
80* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39815480
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39757378
82IGF1R_20145208_ChIP-Seq_DFB_Human1.39609259
83IRF1_19129219_ChIP-ChIP_H3396_Human1.38520596
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38374529
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38096206
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38093744
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37409246
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37396206
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36876283
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36867751
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35378320
92MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33969844
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33574024
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33014036
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32885836
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31790016
97* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30943384
98REST_21632747_ChIP-Seq_MESCs_Mouse1.30337096
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30203928
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29794029
101ZNF263_19887448_ChIP-Seq_K562_Human1.29748575
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29572956
103NCOR1_26117541_ChIP-Seq_K562_Human1.29411968
104P300_18555785_Chip-Seq_ESCs_Mouse1.29270352
105SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29075860
106CIITA_25753668_ChIP-Seq_RAJI_Human1.28872962
107SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28215469
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.28128990
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27735960
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27733227
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27733227
112JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27427681
113BCOR_27268052_Chip-Seq_Bcells_Human1.26840824
114YY1_21170310_ChIP-Seq_MESCs_Mouse1.26400036
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.26144926
116STAT3_18555785_Chip-Seq_ESCs_Mouse1.25406889
117NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24973379
118EGR1_19374776_ChIP-ChIP_THP-1_Human1.24336292
119POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24237614
120* GABP_19822575_ChIP-Seq_HepG2_Human1.23404120
121SMC4_20622854_ChIP-Seq_HELA_Human1.23360479
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23268267
123SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23118264
124GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22416424
125P53_22387025_ChIP-Seq_ESCs_Mouse1.22053195
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21893186
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21379969
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21309467
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21013956
130BCL6_27268052_Chip-Seq_Bcells_Human1.20879290
131KDM2B_26808549_Chip-Seq_JURKAT_Human1.20796602
132ERG_21242973_ChIP-ChIP_JURKAT_Human1.20746865
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20514334
134CMYC_18555785_Chip-Seq_ESCs_Mouse1.20442073
135STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20386048
136P300_19829295_ChIP-Seq_ESCs_Human1.20225302
137SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19258711
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18628854
139ETS1_20019798_ChIP-Seq_JURKAT_Human1.18625954
140RUNX1_22412390_ChIP-Seq_EML_Mouse1.18069346
141FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17966362
142GATA1_26923725_Chip-Seq_HPCs_Mouse1.17484545
143TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16850517
144NMYC_18555785_Chip-Seq_ESCs_Mouse1.16586688
145CTCF_26484167_Chip-Seq_Bcells_Mouse1.16564403
146PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15847144
147NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15331596
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15313645
149SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13235664
150EZH2_27294783_Chip-Seq_NPCs_Mouse1.13191409
151FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13108538
152CREB1_26743006_Chip-Seq_LNCaP_Human1.12936451
153PIAS1_25552417_ChIP-Seq_VCAP_Human1.12736359
154OCT4_18555785_Chip-Seq_ESCs_Mouse1.12057956
155SOX2_18555785_Chip-Seq_ESCs_Mouse1.11998510
156KLF4_18555785_Chip-Seq_ESCs_Mouse1.11288932
157SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10998161
158PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10700812
159MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10177097
160* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09494352
161SMAD4_21799915_ChIP-Seq_A2780_Human1.09387643
162FOXP1_21924763_ChIP-Seq_HESCs_Human1.09373514
163ZFX_18555785_Chip-Seq_ESCs_Mouse1.09016027
164* PHF8_20622854_ChIP-Seq_HELA_Human1.08935199
165SMAD3_21741376_ChIP-Seq_EPCs_Human1.08463275
166NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07959886
167NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07463720
168RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07437124
169EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07437124
170TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06834680
171DCP1A_22483619_ChIP-Seq_HELA_Human1.06645741
172RUNX1_27457419_Chip-Seq_LIVER_Mouse1.06629786
173SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06235352
174LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06110079
175SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05712609
176CTCF_18555785_Chip-Seq_ESCs_Mouse1.05081500
177* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04402297
178SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04101485
179MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03970570
180KDM5A_27292631_Chip-Seq_BREAST_Human1.03906816
181HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03155504
182ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02991737
183RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02212829
184TCF4_23295773_ChIP-Seq_U87_Human1.02147765
185P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01401829
186TAL1_26923725_Chip-Seq_HPCs_Mouse1.01314832
187SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98407765
188STAT1_20625510_ChIP-Seq_HELA_Human0.98261701
189STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97396375
190EWS_26573619_Chip-Seq_HEK293_Human0.97187739
191ER_23166858_ChIP-Seq_MCF-7_Human0.96875953
192VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96762613
193NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96711118
194MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96107316
195SOX2_16153702_ChIP-ChIP_HESCs_Human0.95878998
196SMAD1_18555785_Chip-Seq_ESCs_Mouse0.95357294
197* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93644652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.75522580
2MP0005058_abnormal_lysosome_morphology3.42266120
3MP0005409_darkened_coat_color3.25063293
4MP0009278_abnormal_bone_marrow3.20097537
5MP0003136_yellow_coat_color3.07863963
6MP0005076_abnormal_cell_differentiation3.04711400
7MP0005451_abnormal_body_composition2.96716519
8MP0002254_reproductive_system_inflammat2.84232588
9MP0004142_abnormal_muscle_tone2.72574996
10MP0006072_abnormal_retinal_apoptosis2.57628206
11MP0001188_hyperpigmentation2.52198094
12MP0004185_abnormal_adipocyte_glucose2.50603297
13MP0003880_abnormal_central_pattern2.45664305
14MP0009333_abnormal_splenocyte_physiolog2.41817873
15MP0003436_decreased_susceptibility_to2.35332216
16MP0008877_abnormal_DNA_methylation2.28915763
17MP0005410_abnormal_fertilization2.24747031
18MP0002102_abnormal_ear_morphology2.23084128
19MP0003172_abnormal_lysosome_physiology2.16203869
20MP0003303_peritoneal_inflammation2.13575557
21MP0005551_abnormal_eye_electrophysiolog2.05592348
22MP0003123_paternal_imprinting2.02699366
23MP0009840_abnormal_foam_cell1.98064960
24MP0008058_abnormal_DNA_repair1.95444825
25MP0001730_embryonic_growth_arrest1.92950742
26MP0006276_abnormal_autonomic_nervous1.91068688
27MP0004858_abnormal_nervous_system1.88663328
28MP0005377_hearing/vestibular/ear_phenot1.87526105
29MP0003878_abnormal_ear_physiology1.87526105
30MP0004133_heterotaxia1.85086792
31MP0003950_abnormal_plasma_membrane1.83099296
32MP0000678_abnormal_parathyroid_gland1.82203761
33MP0002877_abnormal_melanocyte_morpholog1.81639465
34MP0003705_abnormal_hypodermis_morpholog1.80631733
35MP0004742_abnormal_vestibular_system1.79388778
36MP0003111_abnormal_nucleus_morphology1.78113884
37MP0001486_abnormal_startle_reflex1.73852578
38MP0003453_abnormal_keratinocyte_physiol1.73576550
39MP0001529_abnormal_vocalization1.72177746
40MP0003786_premature_aging1.72074339
41MP0005501_abnormal_skin_physiology1.71840434
42MP0005253_abnormal_eye_physiology1.71726770
43MP0004957_abnormal_blastocyst_morpholog1.71294267
44MP0002653_abnormal_ependyma_morphology1.69218712
45MP0001440_abnormal_grooming_behavior1.68305386
46MP0002089_abnormal_postnatal_growth/wei1.68042143
47MP0001986_abnormal_taste_sensitivity1.64175846
48MP0002796_impaired_skin_barrier1.63768993
49MP0003787_abnormal_imprinting1.62520076
50MP0001545_abnormal_hematopoietic_system1.61117751
51MP0005397_hematopoietic_system_phenotyp1.61117751
52MP0009046_muscle_twitch1.58874088
53MP0008260_abnormal_autophagy1.58166309
54MP0003077_abnormal_cell_cycle1.57396826
55MP0002735_abnormal_chemical_nociception1.57189733
56MP0004233_abnormal_muscle_weight1.56902916
57MP0002638_abnormal_pupillary_reflex1.56274829
58MP0003763_abnormal_thymus_physiology1.55485938
59MP0003941_abnormal_skin_development1.55198068
60MP0008995_early_reproductive_senescence1.54280441
61MP0003045_fibrosis1.53955878
62MP0004510_myositis1.53895979
63MP0005257_abnormal_intraocular_pressure1.53352588
64MP0004145_abnormal_muscle_electrophysio1.53234820
65MP0002249_abnormal_larynx_morphology1.51534293
66MP0003938_abnormal_ear_development1.49513601
67MP0003300_gastrointestinal_ulcer1.48669960
68MP0002272_abnormal_nervous_system1.47192525
69MP0001502_abnormal_circadian_rhythm1.44132808
70MP0009672_abnormal_birth_weight1.41318226
71MP0000858_altered_metastatic_potential1.40439759
72MP0000350_abnormal_cell_proliferation1.40263821
73MP0003315_abnormal_perineum_morphology1.39624230
74MP0005423_abnormal_somatic_nervous1.39609793
75MP0003718_maternal_effect1.39227203
76MP0000703_abnormal_thymus_morphology1.38421996
77MP0005464_abnormal_platelet_physiology1.36125842
78MP0002160_abnormal_reproductive_system1.33028489
79MP0002277_abnormal_respiratory_mucosa1.32892667
80MP0000490_abnormal_crypts_of1.32208188
81MP0001348_abnormal_lacrimal_gland1.31066157
82MP0001849_ear_inflammation1.30093297
83MP0003191_abnormal_cellular_cholesterol1.30036720
84MP0000313_abnormal_cell_death1.28867704
85MP0004381_abnormal_hair_follicle1.28638772
86MP0002572_abnormal_emotion/affect_behav1.27436772
87MP0003698_abnormal_male_reproductive1.26647415
88MP0002064_seizures1.25447466
89MP0001501_abnormal_sleep_pattern1.25035083
90MP0000750_abnormal_muscle_regeneration1.24926086
91MP0002398_abnormal_bone_marrow1.24916674
92MP0003566_abnormal_cell_adhesion1.23244423
93MP0000003_abnormal_adipose_tissue1.23159383
94MP0009745_abnormal_behavioral_response1.23100065
95MP0006035_abnormal_mitochondrial_morpho1.22454593
96MP0005666_abnormal_adipose_tissue1.21987554
97MP0000049_abnormal_middle_ear1.21552539
98MP0002396_abnormal_hematopoietic_system1.21304394
99MP0002080_prenatal_lethality1.18769882
100MP0005375_adipose_tissue_phenotype1.16566442
101MP0001727_abnormal_embryo_implantation1.16366637
102MP0000026_abnormal_inner_ear1.16253286
103MP0000566_synostosis1.14793110
104MP0001929_abnormal_gametogenesis1.14652952
105MP0001485_abnormal_pinna_reflex1.13891714
106MP0002752_abnormal_somatic_nervous1.13193228
107MP0000462_abnormal_digestive_system1.11848666
108MP0010307_abnormal_tumor_latency1.11603314
109MP0002557_abnormal_social/conspecific_i1.10123008
110MP0002067_abnormal_sensory_capabilities1.09867654
111MP0008057_abnormal_DNA_replication1.09420692
112MP0001905_abnormal_dopamine_level1.09138552
113MP0002722_abnormal_immune_system1.08735277
114MP0003806_abnormal_nucleotide_metabolis1.08182597
115MP0005394_taste/olfaction_phenotype1.07669014
116MP0005499_abnormal_olfactory_system1.07669014
117MP0000778_abnormal_nervous_system1.07604635
118MP0001963_abnormal_hearing_physiology1.07277768
119MP0005670_abnormal_white_adipose1.07063588
120MP0005379_endocrine/exocrine_gland_phen1.05890576
121MP0001984_abnormal_olfaction1.05178971
122MP0008789_abnormal_olfactory_epithelium1.04671331
123MP0003937_abnormal_limbs/digits/tail_de1.03990668
124MP0002210_abnormal_sex_determination1.01917235
125MP0001970_abnormal_pain_threshold1.01693251
126MP0004808_abnormal_hematopoietic_stem1.00556521
127* MP0002429_abnormal_blood_cell1.00110011
128MP0002736_abnormal_nociception_after0.97434963
129MP0005621_abnormal_cell_physiology0.97038717
130MP0005171_absent_coat_pigmentation0.96809681
131MP0004947_skin_inflammation0.96672399
132MP0000516_abnormal_urinary_system0.96581818
133MP0005367_renal/urinary_system_phenotyp0.96581818
134MP0000015_abnormal_ear_pigmentation0.96003554
135MP0001968_abnormal_touch/_nociception0.94650999
136MP0005000_abnormal_immune_tolerance0.94532198
137MP0001873_stomach_inflammation0.94331888
138MP0000358_abnormal_cell_content/0.93874689
139MP0000685_abnormal_immune_system0.93093059
140MP0000689_abnormal_spleen_morphology0.92317641
141MP0001819_abnormal_immune_cell0.92298650
142MP0005025_abnormal_response_to0.90916091
143MP0002420_abnormal_adaptive_immunity0.90780795
144MP0001672_abnormal_embryogenesis/_devel0.90499352
145MP0005380_embryogenesis_phenotype0.90499352
146MP0003329_amyloid_beta_deposits0.90473958
147MP0010386_abnormal_urinary_bladder0.90331394
148MP0005384_cellular_phenotype0.89558719
149MP0005391_vision/eye_phenotype0.89324942
150MP0000631_abnormal_neuroendocrine_gland0.89277905
151MP0010094_abnormal_chromosome_stability0.88656886
152MP0000465_gastrointestinal_hemorrhage0.88460693
153* MP0000716_abnormal_immune_system0.88457952
154MP0002019_abnormal_tumor_incidence0.87956683
155MP0005195_abnormal_posterior_eye0.87894337
156MP0009931_abnormal_skin_appearance0.87802560
157MP0001661_extended_life_span0.86620233
158MP0003866_abnormal_defecation0.86345442
159MP0003635_abnormal_synaptic_transmissio0.86067331
160MP0003693_abnormal_embryo_hatching0.85023295
161MP0001697_abnormal_embryo_size0.84705904
162MP0002085_abnormal_embryonic_tissue0.83980628
163MP0008932_abnormal_embryonic_tissue0.83402140
164MP0002163_abnormal_gland_morphology0.82998111
165MP0002733_abnormal_thermal_nociception0.82715657
166MP0002063_abnormal_learning/memory/cond0.81106562
167MP0002734_abnormal_mechanical_nocicepti0.81033550
168MP0002723_abnormal_immune_serum0.80975618
169MP0002822_catalepsy0.80745483
170MP0002882_abnormal_neuron_morphology0.80361879
171MP0005645_abnormal_hypothalamus_physiol0.80275659
172MP0002229_neurodegeneration0.78703373
173MP0001145_abnormal_male_reproductive0.78084189
174MP0001324_abnormal_eye_pigmentation0.77576013
175MP0000653_abnormal_sex_gland0.77339120
176MP0003984_embryonic_growth_retardation0.77272549
177MP0005310_abnormal_salivary_gland0.76880089
178MP0005395_other_phenotype0.75994949
179MP0002751_abnormal_autonomic_nervous0.75469005
180MP0002184_abnormal_innervation0.74855760
181MP0002086_abnormal_extraembryonic_tissu0.73471265
182MP0005083_abnormal_biliary_tract0.71631219
183MP0002148_abnormal_hypersensitivity_rea0.70923617
184MP0002088_abnormal_embryonic_growth/wei0.70205906
185MP0002405_respiratory_system_inflammati0.69371369
186MP0002452_abnormal_antigen_presenting0.67511366

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)4.30580527
2Absent/shortened dynein arms (HP:0200106)4.30580527
3Hyperacusis (HP:0010780)4.25414865
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.01054133
5Abnormal respiratory epithelium morphology (HP:0012253)3.51408819
6Abnormal respiratory motile cilium morphology (HP:0005938)3.51408819
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.44972156
8Long palpebral fissure (HP:0000637)3.43839302
9Abnormal ciliary motility (HP:0012262)3.32164036
10Abnormality of homocysteine metabolism (HP:0010919)3.20814646
11Homocystinuria (HP:0002156)3.20814646
12Abnormal respiratory motile cilium physiology (HP:0012261)3.11782562
13Insomnia (HP:0100785)3.02478986
14Chromsome breakage (HP:0040012)3.01568855
15Truncus arteriosus (HP:0001660)2.98317217
16Hypercortisolism (HP:0001578)2.87341752
17Achilles tendon contracture (HP:0001771)2.87032029
18Duplicated collecting system (HP:0000081)2.85694381
19Ulnar bowing (HP:0003031)2.84705542
20Overriding aorta (HP:0002623)2.78702947
21Hyperthyroidism (HP:0000836)2.75856772
22Nephronophthisis (HP:0000090)2.74564885
23Focal motor seizures (HP:0011153)2.73945019
24Medial flaring of the eyebrow (HP:0010747)2.70128505
25Ragged-red muscle fibers (HP:0003200)2.68846639
26Progressive muscle weakness (HP:0003323)2.61203603
27Atelectasis (HP:0100750)2.60036950
28Abnormality of the renal collecting system (HP:0004742)2.58241406
29Confusion (HP:0001289)2.58136244
30Distal lower limb amyotrophy (HP:0008944)2.57223435
31Difficulty climbing stairs (HP:0003551)2.54945195
32Stomach cancer (HP:0012126)2.54220192
33Abnormality of the renal medulla (HP:0100957)2.53313937
34Pancreatic fibrosis (HP:0100732)2.52583723
35Hyperparathyroidism (HP:0000843)2.49347168
36Decreased central vision (HP:0007663)2.46148927
37Split foot (HP:0001839)2.45984870
38Petechiae (HP:0000967)2.43584290
39Abnormality of the Achilles tendon (HP:0005109)2.43063834
40Distal upper limb amyotrophy (HP:0007149)2.42500393
41Upper limb amyotrophy (HP:0009129)2.42500393
42Obstructive sleep apnea (HP:0002870)2.42125535
43Morphological abnormality of the middle ear (HP:0008609)2.40597986
44Pancreatic cysts (HP:0001737)2.37984966
45Cholecystitis (HP:0001082)2.37285586
46Abnormal gallbladder physiology (HP:0012438)2.37285586
47Abnormality of macrophages (HP:0004311)2.35029629
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32045282
49Stridor (HP:0010307)2.31181914
50Septo-optic dysplasia (HP:0100842)2.30381846
51Hypertensive crisis (HP:0100735)2.28311593
52Congenital stationary night blindness (HP:0007642)2.27656755
53Bilateral microphthalmos (HP:0007633)2.27194576
54Increased cerebral lipofuscin (HP:0011813)2.26047481
55Eczematoid dermatitis (HP:0000976)2.25686650
56Urethral obstruction (HP:0000796)2.25597593
57Pointed chin (HP:0000307)2.24814617
58Hypercalcemia (HP:0003072)2.23815847
59Anteriorly placed anus (HP:0001545)2.23129276
60Broad distal phalanx of finger (HP:0009836)2.21310684
61Trismus (HP:0000211)2.20557975
62True hermaphroditism (HP:0010459)2.20180988
63Seborrheic dermatitis (HP:0001051)2.18580746
64Congenital primary aphakia (HP:0007707)2.17767701
65Gait imbalance (HP:0002141)2.17663825
66Myopathic facies (HP:0002058)2.16952282
67Deep palmar crease (HP:0006191)2.16920119
68Patellar dislocation (HP:0002999)2.16903920
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.12282147
70Anal stenosis (HP:0002025)2.10831204
71Centrally nucleated skeletal muscle fibers (HP:0003687)2.10670448
72Elfin facies (HP:0004428)2.10210851
73Methylmalonic acidemia (HP:0002912)2.08825936
74Febrile seizures (HP:0002373)2.08402411
75Purpura (HP:0000979)2.08156970
76Obstructive lung disease (HP:0006536)2.07740942
77Chronic obstructive pulmonary disease (HP:0006510)2.07740942
78Abnormality of DNA repair (HP:0003254)2.05844736
79Nephrogenic diabetes insipidus (HP:0009806)2.05410409
80Hand muscle atrophy (HP:0009130)2.04959973
81Attenuation of retinal blood vessels (HP:0007843)2.03449033
82Abnormality of midbrain morphology (HP:0002418)2.02988026
83Molar tooth sign on MRI (HP:0002419)2.02988026
84Increased muscle lipid content (HP:0009058)2.01662530
85Loss of speech (HP:0002371)2.00651661
86Bowel incontinence (HP:0002607)1.99865824
87Microvesicular hepatic steatosis (HP:0001414)1.99634278
88Abnormal large intestine physiology (HP:0012700)1.98765911
89Dysautonomia (HP:0002459)1.98442137
90Aganglionic megacolon (HP:0002251)1.98351153
91Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98035993
92Supernumerary spleens (HP:0009799)1.97579929
93Abnormality of molar morphology (HP:0011070)1.97489531
94Abnormality of molar (HP:0011077)1.97489531
95Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96468633
96Median cleft lip (HP:0000161)1.94572217
97Dyschromatopsia (HP:0007641)1.93744306
98Abnormality of the columella (HP:0009929)1.93337280
99Gastrointestinal dysmotility (HP:0002579)1.92899517
100Broad face (HP:0000283)1.92536585
101Tubulointerstitial nephritis (HP:0001970)1.92290462
102Hypoparathyroidism (HP:0000829)1.92161939
103Vaginal fistula (HP:0004320)1.92076234
104Aplasia/Hypoplasia of the lens (HP:0008063)1.91952955
105Tented upper lip vermilion (HP:0010804)1.91614854
106Abnormality of the dental root (HP:0006486)1.91311318
107Taurodontia (HP:0000679)1.91311318
108Abnormality of permanent molar morphology (HP:0011071)1.91311318
109Cellulitis (HP:0100658)1.91095706
110Prolonged bleeding time (HP:0003010)1.90395230
111Anomalous pulmonary venous return (HP:0010772)1.90205057
112Abnormality of the dental pulp (HP:0006479)1.89710259
113Hypertriglyceridemia (HP:0002155)1.89484203
114Congenital hepatic fibrosis (HP:0002612)1.89087003
115Overfolded helix (HP:0000396)1.88777776
116Lower limb amyotrophy (HP:0007210)1.88552284
117Supernumerary bones of the axial skeleton (HP:0009144)1.88508224
118Optic disc pallor (HP:0000543)1.88000201
119Preaxial hand polydactyly (HP:0001177)1.87592828
120Limb dystonia (HP:0002451)1.83611203
121Renal dysplasia (HP:0000110)1.83367927
122Increased serum ferritin (HP:0003281)1.82245833
123Failure to thrive in infancy (HP:0001531)1.81979714
124Abnormality of glycolipid metabolism (HP:0010969)1.81654646
125Abnormality of liposaccharide metabolism (HP:0010968)1.81654646
126Abnormality of glycosphingolipid metabolism (HP:0004343)1.81654646
127Severe visual impairment (HP:0001141)1.81269908
128Rough bone trabeculation (HP:0100670)1.80975661
129Vaginal atresia (HP:0000148)1.80783825
130Growth hormone excess (HP:0000845)1.80755318
131Squamous cell carcinoma (HP:0002860)1.80681926
132Cholelithiasis (HP:0001081)1.80344033
133Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.79394899
134Poor coordination (HP:0002370)1.79068251
135Intestinal atresia (HP:0011100)1.79063023
136Abnormal hair whorl (HP:0010721)1.77985421
137Male pseudohermaphroditism (HP:0000037)1.77664637
138Abnormality of the thoracic spine (HP:0100711)1.77403223
139Rhinitis (HP:0012384)1.77319837
140Supernumerary ribs (HP:0005815)1.77092955
141Abnormally folded helix (HP:0008544)1.76981151
142Increased connective tissue (HP:0009025)1.76844964
143Distal lower limb muscle weakness (HP:0009053)1.76656065
144Genital tract atresia (HP:0001827)1.76160505
145Optic nerve hypoplasia (HP:0000609)1.75726953
146Submucous cleft hard palate (HP:0000176)1.75299924
147Abnormality of the gallbladder (HP:0005264)1.75057865
148Duplication of thumb phalanx (HP:0009942)1.75050196
149Absent radius (HP:0003974)1.74204010
150Concave nail (HP:0001598)1.73519229
151Retinitis pigmentosa (HP:0000510)1.72710579
152Ankle clonus (HP:0011448)1.72523691
153Congenital sensorineural hearing impairment (HP:0008527)1.72458925
154Prostate neoplasm (HP:0100787)1.72102851
155Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.71676792
156Septate vagina (HP:0001153)1.71211881
157Reticulocytosis (HP:0001923)1.71018240
158Thoracic kyphosis (HP:0002942)1.71014567
159Unilateral renal agenesis (HP:0000122)1.70557004
160Testicular atrophy (HP:0000029)1.69903198
161Annular pancreas (HP:0001734)1.69411303
162Aplasia involving forearm bones (HP:0009822)1.68913634
163Absent forearm bone (HP:0003953)1.68913634
164Renal duplication (HP:0000075)1.68816980
165Meckel diverticulum (HP:0002245)1.68189086
166Renovascular hypertension (HP:0100817)1.67941806
167Abnormality of the preputium (HP:0100587)1.67394689
168Increased intramyocellular lipid droplets (HP:0012240)1.66660266
169Absent septum pellucidum (HP:0001331)1.65941248
170Abnormality of lateral ventricle (HP:0030047)1.65788089
171Upper limb muscle weakness (HP:0003484)1.65553084
172Abnormality of the tricuspid valve (HP:0001702)1.65526287
173Supernumerary nipples (HP:0002558)1.65244426
174Ectopic kidney (HP:0000086)1.65196276
175Self-mutilation (HP:0000742)1.64257311
176Genu recurvatum (HP:0002816)1.64154271
177Vertebral compression fractures (HP:0002953)1.64007901
178Selective tooth agenesis (HP:0001592)1.63824788
179Disproportionate tall stature (HP:0001519)1.63820269
180Abnormal rod and cone electroretinograms (HP:0008323)1.63012265
181Aplasia/Hypoplasia of the uvula (HP:0010293)1.61833627
182Renal agenesis (HP:0000104)1.61742172
183Progressive neurologic deterioration (HP:0002344)1.61417035
184Abnormality of the ileum (HP:0001549)1.61160227
185High anterior hairline (HP:0009890)1.60901871
186Abnormal platelet volume (HP:0011876)1.60858077
187Macrocytic anemia (HP:0001972)1.60790507
188Polygenic inheritance (HP:0010982)1.59986593
189Anal atresia (HP:0002023)1.58958605
190Aplasia/Hypoplasia of the patella (HP:0006498)1.58859716
191Abnormality of the pulmonary veins (HP:0011718)1.58306993
192Broad-based gait (HP:0002136)1.58159486
193Abnormality of the vitamin B12 metabolism (HP:0004341)1.57804649
194Prolonged neonatal jaundice (HP:0006579)1.57624390
195Short chin (HP:0000331)1.57472116
196Recurrent bacterial skin infections (HP:0005406)1.56752066
197Astigmatism (HP:0000483)1.56601282
198Gastrointestinal inflammation (HP:0004386)1.56589841
199Turricephaly (HP:0000262)1.55768890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.12447186
2TRIB33.93990149
3SMG13.69078145
4TNIK3.43940600
5CASK3.36242622
6NME23.30779280
7PNCK3.15527961
8MKNK22.98916415
9ERN12.78082899
10CDK122.62653262
11SIK12.49067854
12EEF2K2.44747833
13TAOK12.40193247
14TESK22.33645448
15MAP3K112.31595325
16INSRR2.30492454
17STK162.23486205
18MAP3K61.95220340
19IRAK31.92999994
20IRAK21.87407273
21MAP3K101.79703636
22TTK1.79448929
23IRAK11.77278513
24AKT31.73879486
25MUSK1.69030036
26CDK31.69014702
27ARAF1.64704502
28EPHA21.62874658
29TLK11.62648718
30MAP2K31.60710135
31PIM21.56273203
32PRPF4B1.54973380
33TESK11.51944320
34VRK21.49350163
35KDR1.47330297
36YES11.47164179
37NME11.41890066
38PRKD21.38650189
39BMX1.38247355
40MAP4K11.36279460
41IRAK41.35865537
42PKN11.35738149
43MKNK11.35199900
44BMPR1B1.29203481
45BMPR21.27809687
46SRPK11.25950076
47OBSCN1.25795512
48BUB11.23955021
49MAP2K71.23910456
50PKN21.23371088
51FGFR41.21234554
52BCKDK1.21228163
53ICK1.20537989
54NUAK11.15513811
55MAPK131.13631334
56EIF2AK21.13355852
57ADRBK21.11568165
58CHEK21.11346459
59SIK21.10063125
60BLK1.09827667
61GRK61.08030587
62GRK71.07237499
63STK38L1.04809200
64DYRK1B1.04075018
65NEK61.00943677
66MTOR1.00559138
67BRAF1.00203148
68DYRK30.99540157
69MAP3K80.98208531
70MAP3K10.97413747
71HIPK20.97085831
72CDK40.96223775
73BRD40.95184400
74LRRK20.94847312
75LMTK20.90521731
76PLK40.90160334
77STK390.88896671
78RPS6KA20.87728927
79PBK0.87620931
80CAMK2D0.87350325
81GRK10.85360715
82TXK0.82392044
83FGR0.81792413
84MARK20.81053029
85RPS6KA50.79729993
86CLK10.79590762
87TTN0.78461831
88TBK10.77902733
89MAP3K30.77847154
90PRKD30.76829054
91RPS6KC10.76411145
92RPS6KL10.76411145
93RIPK40.76327209
94PRKCI0.75357230
95DYRK20.74721544
96RPS6KB20.74234453
97PAK40.69998582
98CAMK1G0.69798529
99PIM10.68571090
100PTK60.68521781
101CAMK2B0.68501622
102DMPK0.67758191
103CSNK1A1L0.67401526
104MATK0.66869846
105CDK80.66073405
106PAK10.62814610
107SIK30.61810929
108VRK10.61296436
109DAPK10.61112207
110MAPK110.59951867
111PRKG20.57862464
112STK40.57308345
113TEC0.57286396
114CDK70.56478910
115STK100.56001508
116TAOK20.55932545
117FES0.55922535
118MAP2K20.54679112
119PDPK10.54467622
120AURKA0.54170501
121CSNK1E0.54107294
122PIK3CA0.53467957
123TNK20.53143590
124CDK90.51489573
125RPS6KA60.51030285
126NTRK10.50770628
127RPS6KA10.50168680
128PRKCE0.49991766
129AKT20.49955202
130CAMK2A0.49494980
131PLK10.48797255
132CDC70.47893732
133PTK20.47145982
134TYRO30.45862908
135CSNK1G30.45686638
136MAPK150.45683862
137ATR0.45533370
138CHEK10.44399993
139KSR20.44250511
140BCR0.43182685
141ATM0.42177926
142NTRK30.42077651
143CHUK0.41662246
144RIPK10.41031805
145BTK0.40652861
146OXSR10.40304775
147MAP3K40.39866341
148CAMK1D0.39698237
149ZAP700.39590114
150MARK30.39187928
151CDK20.38187904
152PLK30.37979648
153WNK40.37951560
154CSK0.37800632
155PRKG10.37513618
156LIMK10.37172147
157MAP3K90.37112506
158IKBKB0.36889236
159MAPKAPK20.35974438
160NLK0.35339934
161ADRBK10.35333218
162CDC42BPA0.34964017
163CSNK1G10.34299011
164CSNK1A10.33726796
165CAMK2G0.33485264
166ILK0.33480345
167DYRK1A0.32875779
168EPHB10.31572319
169GSK3B0.31345972
170CAMK10.31223207
171DAPK30.30777913
172MAPKAPK50.30759666
173PRKACA0.30515981
174MAP3K120.29959708

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.22854300
2Nicotine addiction_Homo sapiens_hsa050333.11269229
3Fanconi anemia pathway_Homo sapiens_hsa034602.85460824
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29111037
5RNA polymerase_Homo sapiens_hsa030202.25946595
6Homologous recombination_Homo sapiens_hsa034402.08386820
7Acute myeloid leukemia_Homo sapiens_hsa052212.07450689
8Basal transcription factors_Homo sapiens_hsa030222.03364537
9Oxidative phosphorylation_Homo sapiens_hsa001901.96749834
10Bladder cancer_Homo sapiens_hsa052191.82471979
11Thyroid cancer_Homo sapiens_hsa052161.75780933
12Nucleotide excision repair_Homo sapiens_hsa034201.68185417
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68044755
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57905801
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57378789
16Chronic myeloid leukemia_Homo sapiens_hsa052201.55918938
17Taste transduction_Homo sapiens_hsa047421.51725489
18Pentose phosphate pathway_Homo sapiens_hsa000301.51670620
19Vibrio cholerae infection_Homo sapiens_hsa051101.51619008
20Folate biosynthesis_Homo sapiens_hsa007901.51317211
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48840349
22Non-small cell lung cancer_Homo sapiens_hsa052231.47707208
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.45905382
24Huntingtons disease_Homo sapiens_hsa050161.44941863
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41168745
26Shigellosis_Homo sapiens_hsa051311.37910360
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36407314
28Vitamin digestion and absorption_Homo sapiens_hsa049771.35245771
29Vitamin B6 metabolism_Homo sapiens_hsa007501.35208608
30Serotonergic synapse_Homo sapiens_hsa047261.34023308
31VEGF signaling pathway_Homo sapiens_hsa043701.32018827
32Sphingolipid metabolism_Homo sapiens_hsa006001.28582466
33Galactose metabolism_Homo sapiens_hsa000521.26240544
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25816001
35Circadian rhythm_Homo sapiens_hsa047101.25351565
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24512577
37Ether lipid metabolism_Homo sapiens_hsa005651.24247016
38Mismatch repair_Homo sapiens_hsa034301.22776454
39Spliceosome_Homo sapiens_hsa030401.22487332
40Longevity regulating pathway - mammal_Homo sapiens_hsa042111.22246989
41Morphine addiction_Homo sapiens_hsa050321.21086288
42Glutamatergic synapse_Homo sapiens_hsa047241.20617215
43Viral carcinogenesis_Homo sapiens_hsa052031.20501368
44Biosynthesis of amino acids_Homo sapiens_hsa012301.19524991
45Apoptosis_Homo sapiens_hsa042101.18457480
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.17138546
47Base excision repair_Homo sapiens_hsa034101.15587051
48Endometrial cancer_Homo sapiens_hsa052131.15076768
49Alzheimers disease_Homo sapiens_hsa050101.14744813
50Cardiac muscle contraction_Homo sapiens_hsa042601.13966394
51Arachidonic acid metabolism_Homo sapiens_hsa005901.12586079
52Ribosome_Homo sapiens_hsa030101.11598837
53Parkinsons disease_Homo sapiens_hsa050121.11323187
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09878652
55Collecting duct acid secretion_Homo sapiens_hsa049661.07461537
56Purine metabolism_Homo sapiens_hsa002301.07390407
57B cell receptor signaling pathway_Homo sapiens_hsa046621.06584343
58Pyrimidine metabolism_Homo sapiens_hsa002401.05362778
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04153840
60Neurotrophin signaling pathway_Homo sapiens_hsa047221.04133584
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.02883431
62Salmonella infection_Homo sapiens_hsa051321.02820544
63DNA replication_Homo sapiens_hsa030301.02549552
64mTOR signaling pathway_Homo sapiens_hsa041501.02284600
65Osteoclast differentiation_Homo sapiens_hsa043801.01259238
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00561418
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00499787
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98733602
69T cell receptor signaling pathway_Homo sapiens_hsa046600.98643458
70Non-homologous end-joining_Homo sapiens_hsa034500.98092726
71Hepatitis B_Homo sapiens_hsa051610.96991207
72Hepatitis C_Homo sapiens_hsa051600.96932337
73Pancreatic cancer_Homo sapiens_hsa052120.96714744
74GABAergic synapse_Homo sapiens_hsa047270.96699170
75Regulation of autophagy_Homo sapiens_hsa041400.94953709
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94203234
77Fructose and mannose metabolism_Homo sapiens_hsa000510.93898639
78Linoleic acid metabolism_Homo sapiens_hsa005910.93581160
79Endocytosis_Homo sapiens_hsa041440.92714762
80Lysosome_Homo sapiens_hsa041420.91780344
81Circadian entrainment_Homo sapiens_hsa047130.91221774
82Insulin signaling pathway_Homo sapiens_hsa049100.90732794
83Prion diseases_Homo sapiens_hsa050200.90487157
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90215321
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89986978
86Amphetamine addiction_Homo sapiens_hsa050310.89934330
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89373024
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88782729
89AMPK signaling pathway_Homo sapiens_hsa041520.86927936
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.86123620
91Calcium signaling pathway_Homo sapiens_hsa040200.85445902
92Cell cycle_Homo sapiens_hsa041100.84840958
93TNF signaling pathway_Homo sapiens_hsa046680.84492212
94Long-term depression_Homo sapiens_hsa047300.84169752
95Primary immunodeficiency_Homo sapiens_hsa053400.83766340
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83188849
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82813695
98mRNA surveillance pathway_Homo sapiens_hsa030150.82135045
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81557885
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80241515
101RNA degradation_Homo sapiens_hsa030180.79653907
102Wnt signaling pathway_Homo sapiens_hsa043100.77294180
103Hedgehog signaling pathway_Homo sapiens_hsa043400.77227076
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76632980
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76623031
106ErbB signaling pathway_Homo sapiens_hsa040120.76578182
107Mineral absorption_Homo sapiens_hsa049780.75185438
108Glioma_Homo sapiens_hsa052140.74854923
109HTLV-I infection_Homo sapiens_hsa051660.72673723
110Axon guidance_Homo sapiens_hsa043600.72519598
111Long-term potentiation_Homo sapiens_hsa047200.72273402
112Insulin secretion_Homo sapiens_hsa049110.71865393
113Basal cell carcinoma_Homo sapiens_hsa052170.71172758
114Colorectal cancer_Homo sapiens_hsa052100.69234594
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68109416
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67229946
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66193682
118Sulfur relay system_Homo sapiens_hsa041220.66182717
119Alcoholism_Homo sapiens_hsa050340.66176757
120Salivary secretion_Homo sapiens_hsa049700.65197584
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.63679661
122Renal cell carcinoma_Homo sapiens_hsa052110.63435926
123RNA transport_Homo sapiens_hsa030130.63343492
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62718344
125Prostate cancer_Homo sapiens_hsa052150.62581626
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.62564079
127Proteasome_Homo sapiens_hsa030500.61910026
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61888590
129Rheumatoid arthritis_Homo sapiens_hsa053230.60224867
130N-Glycan biosynthesis_Homo sapiens_hsa005100.60106400
131Small cell lung cancer_Homo sapiens_hsa052220.59852878
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.58764721
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58218589
134MicroRNAs in cancer_Homo sapiens_hsa052060.57324785
135Synaptic vesicle cycle_Homo sapiens_hsa047210.56063018
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55692199
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.55482126
138Autoimmune thyroid disease_Homo sapiens_hsa053200.55216443
139Cocaine addiction_Homo sapiens_hsa050300.55175475
140Steroid biosynthesis_Homo sapiens_hsa001000.54581792
141Intestinal immune network for IgA production_Homo sapiens_hsa046720.54384032
142Choline metabolism in cancer_Homo sapiens_hsa052310.54036698
143Inositol phosphate metabolism_Homo sapiens_hsa005620.52370932
144Hematopoietic cell lineage_Homo sapiens_hsa046400.52158259
145Prolactin signaling pathway_Homo sapiens_hsa049170.52019537
146* NF-kappa B signaling pathway_Homo sapiens_hsa040640.51865488
147Other glycan degradation_Homo sapiens_hsa005110.51337126
148p53 signaling pathway_Homo sapiens_hsa041150.51058417
149Influenza A_Homo sapiens_hsa051640.50769749
150* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50104275
151Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49901480
152Measles_Homo sapiens_hsa051620.49644340
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.49481675
154Notch signaling pathway_Homo sapiens_hsa043300.49419389
155Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48809230
156African trypanosomiasis_Homo sapiens_hsa051430.47706947
157Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47585770
158MAPK signaling pathway_Homo sapiens_hsa040100.47201928
159Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47190113
160Legionellosis_Homo sapiens_hsa051340.45122339
161NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45003776
162Ovarian steroidogenesis_Homo sapiens_hsa049130.43341504
163Dopaminergic synapse_Homo sapiens_hsa047280.43126663
164Herpes simplex infection_Homo sapiens_hsa051680.42768797
165Protein export_Homo sapiens_hsa030600.42625831
166Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42162940
167Epstein-Barr virus infection_Homo sapiens_hsa051690.42088020
168Asthma_Homo sapiens_hsa053100.41632342
169Ras signaling pathway_Homo sapiens_hsa040140.41060864
170Oocyte meiosis_Homo sapiens_hsa041140.40444609
171Dilated cardiomyopathy_Homo sapiens_hsa054140.40048427
172Cholinergic synapse_Homo sapiens_hsa047250.39752368
173Oxytocin signaling pathway_Homo sapiens_hsa049210.39742143

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