PIBF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is induced by the steroid hormone progesterone and plays a role in the maintenance of pregnancy. The encoded protein regulates multiple facets of the immune system to promote normal pregnancy including cytokine synthesis, natural killer (NK) cell activity, and arachidonic acid metabolism. Low serum levels of this protein have been associated with spontaneous pre-term labor in humans. This protein may promote the proliferation, migration and invasion of glioma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neural tube formation (GO:0001841)4.82517203
2protein K11-linked deubiquitination (GO:0035871)4.30063853
3centriole replication (GO:0007099)4.28671562
4epithelial cilium movement (GO:0003351)3.89064906
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73572993
6rRNA modification (GO:0000154)3.60666300
7DNA ligation (GO:0006266)3.60436839
8rRNA methylation (GO:0031167)3.59717593
9telomere maintenance via recombination (GO:0000722)3.59516913
10histone H2A acetylation (GO:0043968)3.52023811
11protein prenylation (GO:0018342)3.50285809
12prenylation (GO:0097354)3.50285809
13telomere maintenance via semi-conservative replication (GO:0032201)3.47954041
14CENP-A containing nucleosome assembly (GO:0034080)3.46758325
15RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.45205617
16mitotic recombination (GO:0006312)3.44177834
17cilium or flagellum-dependent cell motility (GO:0001539)3.41489189
18cilium movement (GO:0003341)3.41373991
19piRNA metabolic process (GO:0034587)3.39444535
20chromatin remodeling at centromere (GO:0031055)3.38957847
21regulation of meiosis I (GO:0060631)3.37323332
22microtubule depolymerization (GO:0007019)3.36676815
23double-strand break repair via homologous recombination (GO:0000724)3.33721732
24recombinational repair (GO:0000725)3.33132344
25respiratory chain complex IV assembly (GO:0008535)3.32517011
26maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.29690794
27viral mRNA export from host cell nucleus (GO:0046784)3.27162177
28exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25824701
29DNA double-strand break processing (GO:0000729)3.25479625
30replication fork processing (GO:0031297)3.24640933
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24186985
32maturation of 5.8S rRNA (GO:0000460)3.19833783
33protein K63-linked deubiquitination (GO:0070536)3.19092928
34rRNA catabolic process (GO:0016075)3.16412149
35DNA replication initiation (GO:0006270)3.15284064
36DNA synthesis involved in DNA repair (GO:0000731)3.14415657
37protein complex biogenesis (GO:0070271)3.13701303
38transcription-coupled nucleotide-excision repair (GO:0006283)3.13108817
39establishment of protein localization to Golgi (GO:0072600)3.12201277
40axoneme assembly (GO:0035082)3.11336897
41protein-cofactor linkage (GO:0018065)3.10438502
42mitotic metaphase plate congression (GO:0007080)3.09826936
437-methylguanosine mRNA capping (GO:0006370)3.09626785
44negative regulation of DNA recombination (GO:0045910)3.09435661
45cilium organization (GO:0044782)3.09262249
46cilium assembly (GO:0042384)3.08237883
47telomere maintenance (GO:0000723)3.08067401
48negative regulation of DNA-dependent DNA replication (GO:2000104)3.06837830
49telomere organization (GO:0032200)3.06489738
507-methylguanosine RNA capping (GO:0009452)3.06332596
51RNA capping (GO:0036260)3.06332596
52mitochondrial respiratory chain complex assembly (GO:0033108)3.06276624
53DNA strand elongation (GO:0022616)3.05485593
54metaphase plate congression (GO:0051310)3.04552575
55DNA strand elongation involved in DNA replication (GO:0006271)3.03821282
56DNA replication-independent nucleosome assembly (GO:0006336)3.02674126
57DNA replication-independent nucleosome organization (GO:0034724)3.02674126
58DNA integration (GO:0015074)3.02501955
59synapsis (GO:0007129)3.00995219
60sequestering of actin monomers (GO:0042989)3.00020763
61kinetochore organization (GO:0051383)2.98301059
62centriole assembly (GO:0098534)2.97584815
63histone exchange (GO:0043486)2.97266883
64monoubiquitinated protein deubiquitination (GO:0035520)2.97244311
65DNA deamination (GO:0045006)2.96577319
66purine nucleobase biosynthetic process (GO:0009113)2.95789741
67nonmotile primary cilium assembly (GO:0035058)2.95687024
68regulation of helicase activity (GO:0051095)2.90319854
69mismatch repair (GO:0006298)2.90249588
70DNA replication checkpoint (GO:0000076)2.89149211
71cullin deneddylation (GO:0010388)2.88357163
72cytochrome complex assembly (GO:0017004)2.88062613
73telomere maintenance via telomere lengthening (GO:0010833)2.87672707
74reciprocal DNA recombination (GO:0035825)2.87348107
75reciprocal meiotic recombination (GO:0007131)2.87348107
76retinal ganglion cell axon guidance (GO:0031290)2.87059657
77microtubule anchoring (GO:0034453)2.86476158
78nucleotide-excision repair, DNA gap filling (GO:0006297)2.86458274
79behavioral response to ethanol (GO:0048149)2.85700180
80regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.85015141
81regulation of mitotic spindle checkpoint (GO:1903504)2.85015141
82double-strand break repair via nonhomologous end joining (GO:0006303)2.84478363
83non-recombinational repair (GO:0000726)2.84478363
84DNA catabolic process, exonucleolytic (GO:0000738)2.82932807
85mitotic sister chromatid cohesion (GO:0007064)2.82856760
86protein localization to cilium (GO:0061512)2.82124614
87histone mRNA metabolic process (GO:0008334)2.81728958
88behavioral response to nicotine (GO:0035095)2.81190118
89left/right axis specification (GO:0070986)2.80916899
90nucleobase biosynthetic process (GO:0046112)2.80790990
91establishment of chromosome localization (GO:0051303)2.80505919
92peptidyl-histidine modification (GO:0018202)2.80102569
93somite rostral/caudal axis specification (GO:0032525)2.77670195
94cilium morphogenesis (GO:0060271)2.76026127
95DNA unwinding involved in DNA replication (GO:0006268)2.75302717
96transcription elongation from RNA polymerase I promoter (GO:0006362)2.72446486
97histone mRNA catabolic process (GO:0071044)2.72091529
98protein targeting to Golgi (GO:0000042)2.71923691
99termination of RNA polymerase I transcription (GO:0006363)2.71458223
100photoreceptor cell maintenance (GO:0045494)2.70951737
101microtubule polymerization or depolymerization (GO:0031109)2.70102525
102reflex (GO:0060004)2.69852021
103protein deneddylation (GO:0000338)2.69722737
104regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.67969542
105retinal cone cell development (GO:0046549)2.67599510
106nuclear pore complex assembly (GO:0051292)2.67507352
107negative regulation of transcription regulatory region DNA binding (GO:2000678)2.66702455
108regulation of double-strand break repair via homologous recombination (GO:0010569)2.66332967
109spermatid nucleus differentiation (GO:0007289)2.65590858
110protein localization to kinetochore (GO:0034501)2.65460845
111activated T cell proliferation (GO:0050798)2.65247583
112DNA strand renaturation (GO:0000733)2.65027945
113resolution of meiotic recombination intermediates (GO:0000712)2.64726375
114kinetochore assembly (GO:0051382)2.64679205
115centrosome organization (GO:0051297)2.63481005
116meiotic chromosome segregation (GO:0045132)2.63120069
117DNA methylation involved in gamete generation (GO:0043046)2.62069608
118axonemal dynein complex assembly (GO:0070286)2.62050222
119termination of RNA polymerase III transcription (GO:0006386)2.61847056
120transcription elongation from RNA polymerase III promoter (GO:0006385)2.61847056
121microtubule organizing center organization (GO:0031023)2.60638922
122regulation of centriole replication (GO:0046599)2.60609708
123spindle checkpoint (GO:0031577)2.60494125
124ribosome biogenesis (GO:0042254)2.59804076
125mitotic nuclear envelope disassembly (GO:0007077)2.59401826
126regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.59393664
127regulation of glucokinase activity (GO:0033131)2.59242872
128regulation of hexokinase activity (GO:1903299)2.59242872
129positive regulation of action potential (GO:0045760)2.59187008
130regulation of acyl-CoA biosynthetic process (GO:0050812)2.58946726
131transcription elongation from RNA polymerase II promoter (GO:0006368)2.58666046
132antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.58163530
133postreplication repair (GO:0006301)2.57074527
134positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.56922320
135spindle assembly checkpoint (GO:0071173)2.56592389
136negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.55279561
137negative regulation of sister chromatid segregation (GO:0033046)2.55279561
138negative regulation of mitotic sister chromatid separation (GO:2000816)2.55279561
139negative regulation of mitotic sister chromatid segregation (GO:0033048)2.55279561
140nuclear pore organization (GO:0006999)2.54804614
141mitotic spindle assembly checkpoint (GO:0007094)2.54720901
142protein K6-linked ubiquitination (GO:0085020)2.54020077
143ATP-dependent chromatin remodeling (GO:0043044)2.53787254
144mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53721003
145mitochondrial respiratory chain complex I assembly (GO:0032981)2.53721003
146NADH dehydrogenase complex assembly (GO:0010257)2.53721003
147indolalkylamine metabolic process (GO:0006586)2.53601899
148anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.53431628
149nucleotide-excision repair (GO:0006289)2.53396059
150male meiosis I (GO:0007141)2.51142228
151negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.50625499
152attachment of spindle microtubules to kinetochore (GO:0008608)2.50463432
153double-strand break repair (GO:0006302)2.50449793
154regulation of mitotic metaphase/anaphase transition (GO:0030071)2.50107462
155negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.49980524
156somatic diversification of immune receptors via somatic mutation (GO:0002566)2.49280723
157somatic hypermutation of immunoglobulin genes (GO:0016446)2.49280723
158DNA topological change (GO:0006265)2.49005662
159DNA demethylation (GO:0080111)2.48957486
160interkinetic nuclear migration (GO:0022027)2.48520739
161response to pheromone (GO:0019236)2.48417934
162male meiosis (GO:0007140)2.47988122
163regulation of histone H3-K9 methylation (GO:0051570)2.47444952
164proteasome assembly (GO:0043248)2.47422261
165negative regulation of chromosome segregation (GO:0051985)2.47373040
166regulation of mitotic sister chromatid separation (GO:0010965)2.46875600
167regulation of mitotic sister chromatid segregation (GO:0033047)2.46875600
168regulation of sister chromatid segregation (GO:0033045)2.46875600
169regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.46628689
170tachykinin receptor signaling pathway (GO:0007217)2.46517410
171regulation of spindle organization (GO:0090224)2.46463905
172intraciliary transport (GO:0042073)2.46085864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.82322861
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.71184604
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.31649596
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.16904344
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.14314104
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.08942078
7GBX2_23144817_ChIP-Seq_PC3_Human2.87497346
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.84225412
9ELK1_19687146_ChIP-ChIP_HELA_Human2.72830666
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65337606
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64938820
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.63371867
13IGF1R_20145208_ChIP-Seq_DFB_Human2.55220564
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52862174
15* VDR_23849224_ChIP-Seq_CD4+_Human2.51495108
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42813980
17FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.37276535
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36029126
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34182260
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32587375
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.28785280
22VDR_22108803_ChIP-Seq_LS180_Human2.24340617
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22522470
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21042457
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19781887
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.19122142
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16569557
28MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15177122
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13103883
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12833133
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12299731
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05255426
33HOXB4_20404135_ChIP-ChIP_EML_Mouse2.01973143
34FOXP3_21729870_ChIP-Seq_TREG_Human2.01330083
35SRF_21415370_ChIP-Seq_HL-1_Mouse2.01030168
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00305642
37P300_19829295_ChIP-Seq_ESCs_Human1.94209296
38FUS_26573619_Chip-Seq_HEK293_Human1.93940592
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93667858
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86912813
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.80552143
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.80126236
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79505608
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75868157
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.69765809
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.68436104
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.68294773
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.67308753
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64934097
50* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64747084
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.62083899
52SMAD4_21799915_ChIP-Seq_A2780_Human1.61062284
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59329569
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59129459
55ER_23166858_ChIP-Seq_MCF-7_Human1.58193462
56CBP_20019798_ChIP-Seq_JUKART_Human1.56222148
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56222148
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56153979
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55584428
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55158976
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54138848
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53744618
63DCP1A_22483619_ChIP-Seq_HELA_Human1.52785619
64EWS_26573619_Chip-Seq_HEK293_Human1.52464250
65AR_21909140_ChIP-Seq_LNCAP_Human1.50675036
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50524664
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49459619
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48321822
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47561193
70STAT3_23295773_ChIP-Seq_U87_Human1.47475081
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45637088
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45099570
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44382851
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43101473
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41758633
76* GABP_19822575_ChIP-Seq_HepG2_Human1.41657205
77* XRN2_22483619_ChIP-Seq_HELA_Human1.41650680
78AR_25329375_ChIP-Seq_VCAP_Human1.41152807
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.41059253
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.39760199
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38822092
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.38386598
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36291822
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35999974
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35712134
86* TTF2_22483619_ChIP-Seq_HELA_Human1.34457269
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34079571
88TP53_22573176_ChIP-Seq_HFKS_Human1.33981230
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32496065
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32177520
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31072228
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.30603705
93TCF4_23295773_ChIP-Seq_U87_Human1.30182825
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.30122822
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28736032
96BCAT_22108803_ChIP-Seq_LS180_Human1.28371933
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28076081
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26719387
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23096431
100RNF2_27304074_Chip-Seq_NSC_Mouse1.21678064
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21196947
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20931974
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20668015
104CIITA_25753668_ChIP-Seq_RAJI_Human1.18892602
105SMAD3_21741376_ChIP-Seq_EPCs_Human1.18501225
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18219444
107SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18192386
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17615560
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17474016
110P53_22387025_ChIP-Seq_ESCs_Mouse1.15871128
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.15575899
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15149058
113TCF4_22108803_ChIP-Seq_LS180_Human1.13961937
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13725294
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13725294
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13369590
117ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13326253
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.10748087
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10527902
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.10383404
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09942690
122RUNX2_22187159_ChIP-Seq_PCA_Human1.09295415
123SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06125985
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05846832
125EGR1_19374776_ChIP-ChIP_THP-1_Human1.05317406
126* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05153017
127SCL_19346495_ChIP-Seq_HPC-7_Human1.05066927
128FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04748945
129SMAD4_21741376_ChIP-Seq_EPCs_Human1.04321141
130IRF8_21731497_ChIP-ChIP_J774_Mouse1.03571013
131FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03135398
132FOXA1_25329375_ChIP-Seq_VCAP_Human1.03135398
133NANOG_19829295_ChIP-Seq_ESCs_Human1.02909194
134SOX2_19829295_ChIP-Seq_ESCs_Human1.02909194
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02588898
136ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02576719
137ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02267911
138MYC_18940864_ChIP-ChIP_HL60_Human1.02193930
139OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01830671
140NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01742374
141CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01725703
142STAT3_18555785_Chip-Seq_ESCs_Mouse1.01682969
143* SPI1_23547873_ChIP-Seq_NB4_Human1.01677209
144CMYC_18555785_Chip-Seq_ESCs_Mouse1.00934598
145YY1_21170310_ChIP-Seq_MESCs_Mouse1.00772347
146RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00687072
147TAL1_26923725_Chip-Seq_HPCs_Mouse0.99984824
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98553520
149CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98352153
150TFEB_21752829_ChIP-Seq_HELA_Human0.97041816
151SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96559881
152ZNF274_21170338_ChIP-Seq_K562_Hela0.95036768
153IRF8_22096565_ChIP-ChIP_GC-B_Human0.93756944
154ELK1_22589737_ChIP-Seq_MCF10A_Human0.92874404
155E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92326395
156IRF1_19129219_ChIP-ChIP_H3396_Human0.90732939
157KDM5A_27292631_Chip-Seq_BREAST_Human0.90218027
158POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85014062
159FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83661388
160CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82618472
161PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81570186
162NFE2_27457419_Chip-Seq_LIVER_Mouse0.77835913
163SOX17_20123909_ChIP-Seq_XEN_Mouse0.75187979
164TAF15_26573619_Chip-Seq_HEK293_Human0.75120174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.82114254
2MP0003693_abnormal_embryo_hatching3.59216162
3MP0010094_abnormal_chromosome_stability3.41493812
4MP0008058_abnormal_DNA_repair3.35200339
5MP0008877_abnormal_DNA_methylation3.28073153
6MP0003077_abnormal_cell_cycle2.95287338
7MP0008007_abnormal_cellular_replicative2.78329815
8MP0003111_abnormal_nucleus_morphology2.73083840
9MP0001529_abnormal_vocalization2.70978898
10MP0004957_abnormal_blastocyst_morpholog2.46259954
11MP0000569_abnormal_digit_pigmentation2.40101631
12MP0003121_genomic_imprinting2.36709467
13MP0000015_abnormal_ear_pigmentation2.32996484
14MP0004043_abnormal_pH_regulation2.27099919
15MP0006072_abnormal_retinal_apoptosis2.23937406
16MP0003123_paternal_imprinting2.11627242
17MP0003787_abnormal_imprinting2.11014581
18MP0000372_irregular_coat_pigmentation2.08282237
19MP0002396_abnormal_hematopoietic_system2.03601631
20MP0008932_abnormal_embryonic_tissue1.94555645
21MP0003786_premature_aging1.92432108
22MP0006292_abnormal_olfactory_placode1.91297485
23MP0005171_absent_coat_pigmentation1.88697351
24MP0003890_abnormal_embryonic-extraembry1.88661050
25MP0000516_abnormal_urinary_system1.88204928
26MP0005367_renal/urinary_system_phenotyp1.88204928
27MP0003183_abnormal_peptide_metabolism1.85806094
28MP0004808_abnormal_hematopoietic_stem1.84661560
29MP0002163_abnormal_gland_morphology1.83802683
30MP0005253_abnormal_eye_physiology1.82608791
31MP0003880_abnormal_central_pattern1.80533700
32MP0002234_abnormal_pharynx_morphology1.73888273
33MP0000383_abnormal_hair_follicle1.72339445
34MP0002095_abnormal_skin_pigmentation1.60627367
35MP0002938_white_spotting1.58410289
36MP0004142_abnormal_muscle_tone1.54034650
37MP0003136_yellow_coat_color1.52159747
38MP0005174_abnormal_tail_pigmentation1.49478741
39MP0008872_abnormal_physiological_respon1.48526375
40MP0002638_abnormal_pupillary_reflex1.47674283
41MP0005551_abnormal_eye_electrophysiolog1.46231864
42MP0003122_maternal_imprinting1.46049702
43MP0008789_abnormal_olfactory_epithelium1.44952458
44MP0009697_abnormal_copulation1.44561867
45MP0006276_abnormal_autonomic_nervous1.41631943
46MP0002736_abnormal_nociception_after1.40808015
47MP0003195_calcinosis1.39549889
48MP0005075_abnormal_melanosome_morpholog1.39256451
49MP0001968_abnormal_touch/_nociception1.38313132
50MP0002210_abnormal_sex_determination1.36186842
51MP0008875_abnormal_xenobiotic_pharmacok1.36141783
52MP0001929_abnormal_gametogenesis1.35971812
53MP0000427_abnormal_hair_cycle1.34008315
54MP0000631_abnormal_neuroendocrine_gland1.33109277
55MP0005499_abnormal_olfactory_system1.32632562
56MP0005394_taste/olfaction_phenotype1.32632562
57MP0000350_abnormal_cell_proliferation1.30904648
58MP0002160_abnormal_reproductive_system1.30683797
59MP0005187_abnormal_penis_morphology1.28974950
60MP0005084_abnormal_gallbladder_morpholo1.27329633
61MP0008961_abnormal_basal_metabolism1.27203720
62MP0009046_muscle_twitch1.24480552
63MP0002653_abnormal_ependyma_morphology1.23772716
64MP0002277_abnormal_respiratory_mucosa1.23413365
65MP0002132_abnormal_respiratory_system1.22735236
66MP0005645_abnormal_hypothalamus_physiol1.22512038
67MP0001545_abnormal_hematopoietic_system1.19367894
68MP0005397_hematopoietic_system_phenotyp1.19367894
69MP0005410_abnormal_fertilization1.19107084
70MP0001293_anophthalmia1.18959647
71MP0005389_reproductive_system_phenotype1.16637294
72MP0001145_abnormal_male_reproductive1.13348339
73MP0001764_abnormal_homeostasis1.13347458
74MP0000313_abnormal_cell_death1.11516020
75MP0003950_abnormal_plasma_membrane1.10616793
76MP0004133_heterotaxia1.08514913
77MP0001835_abnormal_antigen_presentation1.07329068
78MP0004215_abnormal_myocardial_fiber1.07151973
79MP0001984_abnormal_olfaction1.07072021
80MP0002928_abnormal_bile_duct1.06833951
81MP0001730_embryonic_growth_arrest1.06805024
82MP0002009_preneoplasia1.06343338
83MP0003763_abnormal_thymus_physiology1.06342299
84MP0010678_abnormal_skin_adnexa1.05713971
85MP0002398_abnormal_bone_marrow1.03914452
86MP0000490_abnormal_crypts_of1.02625635
87MP0005671_abnormal_response_to1.02419126
88MP0001188_hyperpigmentation1.02134231
89MP0003698_abnormal_male_reproductive1.02057029
90MP0003943_abnormal_hepatobiliary_system1.00515095
91MP0005408_hypopigmentation1.00249075
92MP0000653_abnormal_sex_gland0.99562174
93MP0001486_abnormal_startle_reflex0.97301275
94MP0004924_abnormal_behavior0.97116836
95MP0005386_behavior/neurological_phenoty0.97116836
96MP0000647_abnormal_sebaceous_gland0.96101581
97MP0003315_abnormal_perineum_morphology0.95822729
98MP0000703_abnormal_thymus_morphology0.95372609
99MP0003941_abnormal_skin_development0.93979950
100MP0005670_abnormal_white_adipose0.93445711
101MP0010307_abnormal_tumor_latency0.93303842
102MP0004147_increased_porphyrin_level0.93136484
103MP0003937_abnormal_limbs/digits/tail_de0.93028053
104MP0008995_early_reproductive_senescence0.91968073
105MP0005379_endocrine/exocrine_gland_phen0.91127089
106MP0006054_spinal_hemorrhage0.90717388
107MP0001986_abnormal_taste_sensitivity0.89937466
108MP0002876_abnormal_thyroid_physiology0.89511443
109MP0000778_abnormal_nervous_system0.88645181
110MP0003984_embryonic_growth_retardation0.88547861
111MP0006036_abnormal_mitochondrial_physio0.87360911
112MP0001186_pigmentation_phenotype0.86768673
113MP0002102_abnormal_ear_morphology0.86543420
114MP0002735_abnormal_chemical_nociception0.86432481
115MP0004742_abnormal_vestibular_system0.86191841
116MP0002837_dystrophic_cardiac_calcinosis0.85058108
117MP0001672_abnormal_embryogenesis/_devel0.84830996
118MP0005380_embryogenesis_phenotype0.84830996
119MP0002177_abnormal_outer_ear0.84790907
120MP0005391_vision/eye_phenotype0.84713993
121MP0002075_abnormal_coat/hair_pigmentati0.83971858
122MP0002282_abnormal_trachea_morphology0.82873641
123MP0001697_abnormal_embryo_size0.82825756
124MP0003567_abnormal_fetal_cardiomyocyte0.82691965
125MP0001119_abnormal_female_reproductive0.82595765
126MP0010386_abnormal_urinary_bladder0.82313514
127MP0002088_abnormal_embryonic_growth/wei0.82239400
128MP0000689_abnormal_spleen_morphology0.82118741
129MP0009333_abnormal_splenocyte_physiolog0.81518086
130MP0002272_abnormal_nervous_system0.81329581
131MP0002085_abnormal_embryonic_tissue0.80800014
132MP0005646_abnormal_pituitary_gland0.80092304
133MP0001485_abnormal_pinna_reflex0.77858291
134MP0002722_abnormal_immune_system0.77599710
135MP0004145_abnormal_muscle_electrophysio0.77463543
136MP0002080_prenatal_lethality0.77158565
137MP0000049_abnormal_middle_ear0.76426853
138MP0002429_abnormal_blood_cell0.76081179
139MP0002019_abnormal_tumor_incidence0.74323473
140MP0002420_abnormal_adaptive_immunity0.74172696
141MP0002166_altered_tumor_susceptibility0.73914138
142MP0000371_diluted_coat_color0.73855931
143MP0001177_atelectasis0.73355077
144MP0003718_maternal_effect0.73272977
145MP0001819_abnormal_immune_cell0.73167449
146MP0000716_abnormal_immune_system0.72943515
147MP0002084_abnormal_developmental_patter0.72906263
148MP0002452_abnormal_antigen_presenting0.72601540
149MP0003119_abnormal_digestive_system0.72149791
150MP0000013_abnormal_adipose_tissue0.72130397
151MP0000465_gastrointestinal_hemorrhage0.71968939
152MP0002751_abnormal_autonomic_nervous0.71711291
153MP0001853_heart_inflammation0.70989532
154MP0009745_abnormal_behavioral_response0.70529888
155MP0002067_abnormal_sensory_capabilities0.70529326
156MP0006035_abnormal_mitochondrial_morpho0.70349079
157MP0002184_abnormal_innervation0.70294036
158MP0008775_abnormal_heart_ventricle0.69771224
159MP0001879_abnormal_lymphatic_vessel0.69308092

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.04834888
2Abnormality of the renal cortex (HP:0011035)3.38763228
3Aplastic anemia (HP:0001915)3.34457553
4Pancreatic fibrosis (HP:0100732)3.33601704
5Chromsome breakage (HP:0040012)3.08711657
6True hermaphroditism (HP:0010459)2.92919152
7Chromosomal breakage induced by crosslinking agents (HP:0003221)2.90039114
8Abnormality of DNA repair (HP:0003254)2.86382404
9Abnormal hair whorl (HP:0010721)2.74322073
10Abnormality of chromosome stability (HP:0003220)2.73815717
11Chronic hepatic failure (HP:0100626)2.68053733
12Embryonal renal neoplasm (HP:0011794)2.66736888
13Nephroblastoma (Wilms tumor) (HP:0002667)2.60381391
14Agnosia (HP:0010524)2.53420617
15Diastasis recti (HP:0001540)2.49463315
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.48863206
17Supernumerary spleens (HP:0009799)2.47875757
18Metaphyseal dysplasia (HP:0100255)2.45993515
19Type 2 muscle fiber atrophy (HP:0003554)2.45470187
20Hepatocellular necrosis (HP:0001404)2.45430348
21Medulloblastoma (HP:0002885)2.39507226
22Pancreatic cysts (HP:0001737)2.38570768
23Nephronophthisis (HP:0000090)2.38168195
24Medial flaring of the eyebrow (HP:0010747)2.38150297
25Hyperventilation (HP:0002883)2.35995782
26Thyroiditis (HP:0100646)2.34642559
27Hepatic necrosis (HP:0002605)2.32169446
28Type I transferrin isoform profile (HP:0003642)2.31825941
29Premature graying of hair (HP:0002216)2.31763840
30Mitochondrial inheritance (HP:0001427)2.31210320
31Febrile seizures (HP:0002373)2.30338732
32Volvulus (HP:0002580)2.30278168
33Abnormal spermatogenesis (HP:0008669)2.29799183
34Papillary thyroid carcinoma (HP:0002895)2.28553401
35Increased CSF lactate (HP:0002490)2.27922350
36Methylmalonic acidemia (HP:0002912)2.25402586
37Prostate neoplasm (HP:0100787)2.23984092
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.22672280
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.22165464
40Male pseudohermaphroditism (HP:0000037)2.22030140
41Increased hepatocellular lipid droplets (HP:0006565)2.20882795
42Meckel diverticulum (HP:0002245)2.20391364
43Short middle phalanx of the 5th finger (HP:0004220)2.20337402
44Myelodysplasia (HP:0002863)2.18003328
45Adrenal hypoplasia (HP:0000835)2.17892845
46Abnormality of the anterior horn cell (HP:0006802)2.17427481
47Degeneration of anterior horn cells (HP:0002398)2.17427481
48Selective tooth agenesis (HP:0001592)2.17133985
49Vaginal atresia (HP:0000148)2.16382466
50Acute myeloid leukemia (HP:0004808)2.16307648
51Postaxial hand polydactyly (HP:0001162)2.15724105
52Abnormality of the columella (HP:0009929)2.13681928
53Occipital encephalocele (HP:0002085)2.12514366
54Tubulointerstitial nephritis (HP:0001970)2.12388971
55Cystic liver disease (HP:0006706)2.10440498
56Patellar aplasia (HP:0006443)2.10384826
57Abnormality of the ileum (HP:0001549)2.09649034
58Abnormal respiratory motile cilium physiology (HP:0012261)2.09441634
59Congenital stationary night blindness (HP:0007642)2.09426942
60Muscle fiber atrophy (HP:0100295)2.09001705
61Aplasia/Hypoplasia of the sternum (HP:0006714)2.08932794
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.08928976
63Absent/shortened dynein arms (HP:0200106)2.08928976
64Renal cortical cysts (HP:0000803)2.08464418
65Congenital primary aphakia (HP:0007707)2.06542382
66Abnormality of the labia minora (HP:0012880)2.05867854
67Breast hypoplasia (HP:0003187)2.05232625
68Acanthocytosis (HP:0001927)2.04805336
69Abnormality of midbrain morphology (HP:0002418)2.04636400
70Molar tooth sign on MRI (HP:0002419)2.04636400
71Entropion (HP:0000621)2.03652444
72Bone marrow hypocellularity (HP:0005528)2.02975168
73Nephrogenic diabetes insipidus (HP:0009806)2.02591002
74Lipid accumulation in hepatocytes (HP:0006561)2.01188674
75Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.00385961
76Small intestinal stenosis (HP:0012848)2.00230364
77Duodenal stenosis (HP:0100867)2.00230364
78Abnormality of the renal medulla (HP:0100957)2.00159838
79Abnormality of the preputium (HP:0100587)1.99928726
80Poor coordination (HP:0002370)1.99414935
81Hypothermia (HP:0002045)1.98930449
82Congenital hepatic fibrosis (HP:0002612)1.98871119
83Sclerocornea (HP:0000647)1.98860169
84Congenital, generalized hypertrichosis (HP:0004540)1.98297986
85Acute encephalopathy (HP:0006846)1.98148563
86Narrow forehead (HP:0000341)1.97788561
87Rhinitis (HP:0012384)1.97397004
88Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.96981198
89Preaxial hand polydactyly (HP:0001177)1.96774757
90Short tibia (HP:0005736)1.96620487
91Microvesicular hepatic steatosis (HP:0001414)1.96326059
9211 pairs of ribs (HP:0000878)1.95930518
93Abnormality of the renal collecting system (HP:0004742)1.94565619
94Sloping forehead (HP:0000340)1.94381337
95Severe combined immunodeficiency (HP:0004430)1.93841462
96Abnormal lung lobation (HP:0002101)1.93324998
973-Methylglutaconic aciduria (HP:0003535)1.92994856
98White forelock (HP:0002211)1.91932028
99Patchy hypopigmentation of hair (HP:0011365)1.91661436
100Abnormal ciliary motility (HP:0012262)1.91550840
101Postaxial foot polydactyly (HP:0001830)1.90987540
102Aplasia/Hypoplasia of the patella (HP:0006498)1.89971966
103Prominent nasal bridge (HP:0000426)1.89884370
104Progressive macrocephaly (HP:0004481)1.89620788
105Abnormal respiratory motile cilium morphology (HP:0005938)1.89317386
106Abnormal respiratory epithelium morphology (HP:0012253)1.89317386
107Fair hair (HP:0002286)1.88457367
108Aganglionic megacolon (HP:0002251)1.88170318
109Syringomyelia (HP:0003396)1.87872087
110Spinal cord lesions (HP:0100561)1.87872087
111Median cleft lip (HP:0000161)1.87543223
112Gait imbalance (HP:0002141)1.87533570
113Astigmatism (HP:0000483)1.86736634
114Anencephaly (HP:0002323)1.86652135
115Abnormal biliary tract physiology (HP:0012439)1.86568508
116Bile duct proliferation (HP:0001408)1.86568508
117Oligodactyly (hands) (HP:0001180)1.85180703
118Prominent nose (HP:0000448)1.85135527
119Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84357767
120Abnormal protein N-linked glycosylation (HP:0012347)1.84357767
121Abnormal protein glycosylation (HP:0012346)1.84357767
122Abnormal glycosylation (HP:0012345)1.84357767
123Clubbing of toes (HP:0100760)1.83458722
124Abnormality of the phalanges of the 5th finger (HP:0004213)1.83359513
125Abolished electroretinogram (ERG) (HP:0000550)1.79714436
126Abnormality of alanine metabolism (HP:0010916)1.79463039
127Hyperalaninemia (HP:0003348)1.79463039
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79463039
129Abnormal number of erythroid precursors (HP:0012131)1.79323795
130Acute necrotizing encephalopathy (HP:0006965)1.79144183
131Impulsivity (HP:0100710)1.79005409
132Gastrointestinal atresia (HP:0002589)1.78386247
133Ectopic kidney (HP:0000086)1.77641340
134Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.77400739
135Methylmalonic aciduria (HP:0012120)1.76841687
136Facial cleft (HP:0002006)1.76831723
137Intestinal atresia (HP:0011100)1.76470820
138B lymphocytopenia (HP:0010976)1.76410859
139Lymphoma (HP:0002665)1.75854526
140Small hand (HP:0200055)1.73569449
141Brushfield spots (HP:0001088)1.73251372
142Oculomotor apraxia (HP:0000657)1.72353393
143Abnormal mitochondria in muscle tissue (HP:0008316)1.69065295
144Gonadotropin excess (HP:0000837)1.68805535
145Acute lymphatic leukemia (HP:0006721)1.67077545
146Genital tract atresia (HP:0001827)1.66387866
147Abnormality of cells of the erythroid lineage (HP:0012130)1.65850529
148Colon cancer (HP:0003003)1.64829194
149Abnormal number of incisors (HP:0011064)1.64402446
150Capillary hemangiomas (HP:0005306)1.63004973
151Abnormality of the duodenum (HP:0002246)1.62355705
152Thyroid carcinoma (HP:0002890)1.61745164
153Aplasia/Hypoplasia of the tibia (HP:0005772)1.61543192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.61726857
2MAP4K23.61025481
3ZAK3.41275523
4TAOK23.15063159
5STK163.11443820
6PRPF4B3.00108904
7WEE12.72018832
8EIF2AK12.68597871
9BUB12.59877020
10MAP3K42.58830260
11CDC72.54714382
12ACVR1B2.38064866
13VRK12.30664877
14PLK42.24894510
15SRPK12.17716067
16MKNK22.16686826
17MKNK12.01810898
18CCNB12.01310173
19BRD41.97686909
20TSSK61.80337124
21NUAK11.75549754
22EIF2AK31.71284077
23ERBB31.70325994
24ATR1.60335679
25PASK1.54049091
26MAP3K121.54008119
27SIK31.47553560
28TNIK1.45175953
29PLK31.39737549
30TAOK31.36075215
31STK31.34577994
32TTK1.34386980
33INSRR1.34297173
34PINK11.30022471
35CDK191.29971229
36TLK11.27762566
37YES11.27442435
38LATS11.26332834
39NEK11.24546789
40PLK11.23471496
41STK241.19112310
42TXK1.18746126
43BRSK21.18534432
44TEC1.16886850
45MST41.16441881
46STK38L1.15700893
47KIT1.14787898
48CDK81.14729355
49AKT31.09476334
50ADRBK21.08473523
51STK391.08129324
52TAF11.06760064
53TRIM281.06170570
54CASK1.02844317
55DYRK31.00922467
56OXSR10.95946815
57EIF2AK20.95787537
58STK40.94975131
59MAP3K60.94317100
60AURKB0.93820106
61CDK120.90791643
62PDK30.89588590
63PDK40.89588590
64CHEK20.89051027
65CDK30.88741422
66FLT30.88419425
67CSNK1G20.88399774
68NEK20.88225731
69GRK10.88045433
70PLK20.85917475
71PIM10.83331367
72PAK30.81763735
73ATM0.81580849
74CSNK1G10.80862659
75MAPK130.80702927
76CDK70.80121737
77IRAK10.79983482
78IKBKE0.79215332
79CLK10.79145323
80CSNK1G30.77622667
81FRK0.77122412
82BMPR20.76887696
83MAP2K70.75761232
84CHEK10.75372005
85CSNK1A1L0.72713878
86RPS6KA50.71278190
87BCR0.71103327
88MAP3K140.71019559
89PRKCE0.69728531
90CAMKK20.69593583
91DYRK1A0.69121712
92FGFR30.66582417
93MAP2K30.65848884
94EPHA30.65742615
95IRAK40.65332839
96SGK20.64415415
97NEK60.64211105
98MUSK0.63350532
99RPS6KA40.63349869
100RPS6KB20.63333005
101DYRK20.62070793
102JAK30.61261035
103BCKDK0.60898685
104IKBKB0.59675355
105PIK3CA0.57717274
106GRK70.56441810
107FER0.53681287
108MARK10.53666636
109BMPR1B0.51640042
110MARK30.49347564
111NEK90.48590128
112TGFBR20.48396301
113CSNK2A10.47496855
114ADRBK10.46949599
115MYLK0.46555882
116PRKCG0.45944158
117MAP2K60.44568571
118BTK0.44354009
119PKN10.44240433
120CHUK0.43883403
121CSNK2A20.43379409
122OBSCN0.41906469
123CDK20.41213851
124TGFBR10.41194097
125MAPK150.41153519
126CDK10.40276601
127STK100.39930090
128CDK40.39592605
129PDK20.38987326
130WNK40.38652140
131NME10.38351110
132PNCK0.37253928
133NME20.36152976
134CSF1R0.36037676
135PBK0.34374745
136LCK0.34087913
137TRPM70.34032097
138RPS6KB10.33762265
139PRKACB0.32996238
140MAP3K50.32888568
141PTK2B0.32816379
142RAF10.32069106
143MAP3K130.31909053
144EPHA40.30715423
145PRKG10.29248741

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.70849024
2DNA replication_Homo sapiens_hsa030303.67702165
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20127159
4RNA polymerase_Homo sapiens_hsa030203.16648692
5Homologous recombination_Homo sapiens_hsa034403.09537402
6Proteasome_Homo sapiens_hsa030502.99834723
7Base excision repair_Homo sapiens_hsa034102.92372884
8Basal transcription factors_Homo sapiens_hsa030222.91645335
9Nucleotide excision repair_Homo sapiens_hsa034202.91504802
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.84782737
11Propanoate metabolism_Homo sapiens_hsa006402.73658494
12Spliceosome_Homo sapiens_hsa030402.64725239
13Cell cycle_Homo sapiens_hsa041102.56081056
14Fanconi anemia pathway_Homo sapiens_hsa034602.55214923
15RNA transport_Homo sapiens_hsa030132.43676112
16Non-homologous end-joining_Homo sapiens_hsa034502.37322925
17Butanoate metabolism_Homo sapiens_hsa006502.22963165
18RNA degradation_Homo sapiens_hsa030182.18533850
19Pyrimidine metabolism_Homo sapiens_hsa002402.03412390
20Ribosome_Homo sapiens_hsa030101.94231523
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92007220
22Protein export_Homo sapiens_hsa030601.73598143
23Caffeine metabolism_Homo sapiens_hsa002321.73404456
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64362954
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61296588
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61105214
27mRNA surveillance pathway_Homo sapiens_hsa030151.59142774
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53184095
29Epstein-Barr virus infection_Homo sapiens_hsa051691.45046029
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.44761792
31Purine metabolism_Homo sapiens_hsa002301.42968264
32Nitrogen metabolism_Homo sapiens_hsa009101.41972956
33Steroid biosynthesis_Homo sapiens_hsa001001.37632854
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36877793
35Linoleic acid metabolism_Homo sapiens_hsa005911.36769422
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33560020
37p53 signaling pathway_Homo sapiens_hsa041151.30168187
38Antigen processing and presentation_Homo sapiens_hsa046121.25031931
39Selenocompound metabolism_Homo sapiens_hsa004501.24900369
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.23729035
41Herpes simplex infection_Homo sapiens_hsa051681.21415279
42Taste transduction_Homo sapiens_hsa047421.20537320
43Nicotine addiction_Homo sapiens_hsa050331.18936870
44Huntingtons disease_Homo sapiens_hsa050161.11565904
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10426428
46One carbon pool by folate_Homo sapiens_hsa006701.10247440
47Systemic lupus erythematosus_Homo sapiens_hsa053221.08078790
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02232469
49Tryptophan metabolism_Homo sapiens_hsa003801.01043926
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99911313
51Ether lipid metabolism_Homo sapiens_hsa005650.99441727
52Peroxisome_Homo sapiens_hsa041460.98622528
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.97997919
54Measles_Homo sapiens_hsa051620.93757253
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.92868458
56Olfactory transduction_Homo sapiens_hsa047400.91486348
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88103191
58Legionellosis_Homo sapiens_hsa051340.85178710
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84546441
60HTLV-I infection_Homo sapiens_hsa051660.83755331
61Retinol metabolism_Homo sapiens_hsa008300.82838269
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81762937
63Chemical carcinogenesis_Homo sapiens_hsa052040.80901145
64Hematopoietic cell lineage_Homo sapiens_hsa046400.79070129
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78071995
66Oocyte meiosis_Homo sapiens_hsa041140.77807972
67Viral carcinogenesis_Homo sapiens_hsa052030.77659031
68Primary immunodeficiency_Homo sapiens_hsa053400.76756716
69Parkinsons disease_Homo sapiens_hsa050120.73091302
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72644248
71Hepatitis B_Homo sapiens_hsa051610.71710046
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71186581
73Pyruvate metabolism_Homo sapiens_hsa006200.70613915
74Influenza A_Homo sapiens_hsa051640.70592954
75Oxidative phosphorylation_Homo sapiens_hsa001900.69935796
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67556342
77Metabolic pathways_Homo sapiens_hsa011000.66329395
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62020097
79N-Glycan biosynthesis_Homo sapiens_hsa005100.61159479
80Arachidonic acid metabolism_Homo sapiens_hsa005900.58348069
81Colorectal cancer_Homo sapiens_hsa052100.58075288
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58006380
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56902464
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56676325
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56589581
86ABC transporters_Homo sapiens_hsa020100.56271796
87Allograft rejection_Homo sapiens_hsa053300.55198607
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54479575
89Glutathione metabolism_Homo sapiens_hsa004800.53494082
90Serotonergic synapse_Homo sapiens_hsa047260.53076803
91Notch signaling pathway_Homo sapiens_hsa043300.52621771
92Lysine degradation_Homo sapiens_hsa003100.52208023
93Apoptosis_Homo sapiens_hsa042100.50278219
94Shigellosis_Homo sapiens_hsa051310.50015069
95Rheumatoid arthritis_Homo sapiens_hsa053230.48914276
96Leishmaniasis_Homo sapiens_hsa051400.48066884
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47903248
98Alcoholism_Homo sapiens_hsa050340.46931888
99TGF-beta signaling pathway_Homo sapiens_hsa043500.44906844
100MicroRNAs in cancer_Homo sapiens_hsa052060.44823913
101Small cell lung cancer_Homo sapiens_hsa052220.43762410
102Regulation of autophagy_Homo sapiens_hsa041400.43531379
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42847240
104GABAergic synapse_Homo sapiens_hsa047270.41676405
105Phagosome_Homo sapiens_hsa041450.40886172
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.39742440
107Fatty acid degradation_Homo sapiens_hsa000710.39263972
108Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38276368
109Glycerolipid metabolism_Homo sapiens_hsa005610.38148332
110Fatty acid metabolism_Homo sapiens_hsa012120.38078508
111Fatty acid elongation_Homo sapiens_hsa000620.37332990
112Salivary secretion_Homo sapiens_hsa049700.36682568
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35987803
114Asthma_Homo sapiens_hsa053100.35111667
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34548715
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.34181832
117Autoimmune thyroid disease_Homo sapiens_hsa053200.33690253
118Morphine addiction_Homo sapiens_hsa050320.33295919
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32905907
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32615924
121Graft-versus-host disease_Homo sapiens_hsa053320.32533263
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32397258
123Wnt signaling pathway_Homo sapiens_hsa043100.32348831
124Viral myocarditis_Homo sapiens_hsa054160.32186521
125Dorso-ventral axis formation_Homo sapiens_hsa043200.31673859
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31513264
127Calcium signaling pathway_Homo sapiens_hsa040200.30670720
128Phototransduction_Homo sapiens_hsa047440.29943702
129Circadian entrainment_Homo sapiens_hsa047130.29836274
130Pathways in cancer_Homo sapiens_hsa052000.28748308
131Pentose phosphate pathway_Homo sapiens_hsa000300.28459065
132Sulfur metabolism_Homo sapiens_hsa009200.27971515
133Dopaminergic synapse_Homo sapiens_hsa047280.26258746
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25816552
135Hedgehog signaling pathway_Homo sapiens_hsa043400.25577412
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25093380
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25038943
138Alzheimers disease_Homo sapiens_hsa050100.24582122
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24473445
140FoxO signaling pathway_Homo sapiens_hsa040680.23614033
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23021969
142Tuberculosis_Homo sapiens_hsa051520.22774299
143T cell receptor signaling pathway_Homo sapiens_hsa046600.21738523
144B cell receptor signaling pathway_Homo sapiens_hsa046620.21402424
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.21351887
146Thyroid cancer_Homo sapiens_hsa052160.20040552
147Hippo signaling pathway_Homo sapiens_hsa043900.19774286
148Circadian rhythm_Homo sapiens_hsa047100.19637661
149HIF-1 signaling pathway_Homo sapiens_hsa040660.19626531
150Malaria_Homo sapiens_hsa051440.18558974
151Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17406118
152Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16243393
153Collecting duct acid secretion_Homo sapiens_hsa049660.16191270
154Sphingolipid metabolism_Homo sapiens_hsa006000.16095345
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15963766
156Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15760740
157Toxoplasmosis_Homo sapiens_hsa051450.15239907

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