PICALM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)4.68301911
2positive regulation of gamma-delta T cell activation (GO:0046645)4.38347178
3negative regulation of erythrocyte differentiation (GO:0045647)4.11678609
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.03339720
5modulation by symbiont of host defense response (GO:0052031)3.90636473
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.90636473
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.90636473
8positive regulation by organism of defense response of other organism involved in symbiotic interact3.90636473
9modulation by symbiont of host immune response (GO:0052553)3.90636473
10positive regulation by symbiont of host defense response (GO:0052509)3.90636473
11detection of external biotic stimulus (GO:0098581)3.68644704
12cell adhesion mediated by integrin (GO:0033627)3.62559262
13detection of other organism (GO:0098543)3.57407251
14protein localization to endosome (GO:0036010)3.56037035
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.55721480
16negative regulation of cell killing (GO:0031342)3.55721480
17regulation of interferon-beta biosynthetic process (GO:0045357)3.35165085
18microglial cell activation (GO:0001774)3.26372263
19response to lipoprotein particle (GO:0055094)3.13998299
20hypotonic response (GO:0006971)3.12980595
21detection of biotic stimulus (GO:0009595)3.12292809
22lipopolysaccharide-mediated signaling pathway (GO:0031663)3.08180008
23response to laminar fluid shear stress (GO:0034616)3.05795728
24macrophage activation involved in immune response (GO:0002281)3.04861694
25negative regulation of interleukin-12 production (GO:0032695)3.04746782
26detection of bacterium (GO:0016045)2.99369476
27regulation of gamma-delta T cell activation (GO:0046643)2.95920497
28positive regulation of macrophage cytokine production (GO:0060907)2.91885182
29embryonic process involved in female pregnancy (GO:0060136)2.88561921
30positive regulation of receptor recycling (GO:0001921)2.85937434
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.85017125
32cellular response to thyroid hormone stimulus (GO:0097067)2.81657472
33regulation of leukocyte degranulation (GO:0043300)2.78945214
34platelet-derived growth factor receptor signaling pathway (GO:0048008)2.78918627
35germinal center formation (GO:0002467)2.78853064
36cortical actin cytoskeleton organization (GO:0030866)2.78084312
37growth hormone receptor signaling pathway (GO:0060396)2.77709347
38regulation of early endosome to late endosome transport (GO:2000641)2.75379578
39regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.72637291
40regulation of mast cell degranulation (GO:0043304)2.72334129
41neutrophil activation involved in immune response (GO:0002283)2.71454453
42antigen processing and presentation of endogenous antigen (GO:0019883)2.69493449
43regulation of T-helper 2 cell differentiation (GO:0045628)2.69096504
44regulation of gamma-delta T cell differentiation (GO:0045586)2.68923419
45JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.67029311
46apoptotic cell clearance (GO:0043277)2.66404403
47retina vasculature morphogenesis in camera-type eye (GO:0061299)2.64755607
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.63355642
49I-kappaB phosphorylation (GO:0007252)2.62399462
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.62368107
51cortical cytoskeleton organization (GO:0030865)2.62088889
52regulation of myeloid leukocyte mediated immunity (GO:0002886)2.59570274
53regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.57883474
54mannose metabolic process (GO:0006013)2.56042093
55positive regulation of interferon-alpha production (GO:0032727)2.55711545
56macrophage activation (GO:0042116)2.55192317
57substrate-dependent cell migration (GO:0006929)2.54489695
58response to fluid shear stress (GO:0034405)2.53874456
59regulation of necroptotic process (GO:0060544)2.53680435
60positive regulation of Cdc42 GTPase activity (GO:0043089)2.52555168
61regulation of interferon-alpha production (GO:0032647)2.52086064
62regulation of macrophage cytokine production (GO:0010935)2.51874856
63virion attachment to host cell (GO:0019062)2.50431888
64adhesion of symbiont to host cell (GO:0044650)2.50431888
65regulation of B cell receptor signaling pathway (GO:0050855)2.50281521
66production of molecular mediator involved in inflammatory response (GO:0002532)2.50099503
67regulation of chemokine secretion (GO:0090196)2.48935465
68barbed-end actin filament capping (GO:0051016)2.48720674
69negative regulation of protein localization to plasma membrane (GO:1903077)2.48653775
70regulation of mast cell activation involved in immune response (GO:0033006)2.48413323
71negative regulation of granulocyte differentiation (GO:0030853)2.48112051
72positive regulation of p38MAPK cascade (GO:1900745)2.46946305
73regulation of dendritic cell antigen processing and presentation (GO:0002604)2.45509206
74myeloid cell activation involved in immune response (GO:0002275)2.43473662
75Rap protein signal transduction (GO:0032486)2.42546362
76vascular endothelial growth factor signaling pathway (GO:0038084)2.42047740
77low-density lipoprotein particle clearance (GO:0034383)2.40651544
78germ cell migration (GO:0008354)2.40331007
79T-helper 1 type immune response (GO:0042088)2.40221717
80cellular response to growth hormone stimulus (GO:0071378)2.38466348
81wound healing, spreading of epidermal cells (GO:0035313)2.38448291
82positive regulation of leukocyte degranulation (GO:0043302)2.37426027
83positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.36651021
84regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.35953025
85response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.35429787
86response to host immune response (GO:0052572)2.35429787
87response to thyroid hormone (GO:0097066)2.34753577
88cellular extravasation (GO:0045123)2.33814727
89negative regulation of type 2 immune response (GO:0002829)2.31809474
90negative regulation of lymphocyte mediated immunity (GO:0002707)2.31745116
91positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.31391688
92establishment of endothelial barrier (GO:0061028)2.30796201
93antigen processing and presentation via MHC class Ib (GO:0002475)2.30403881
94positive regulation of chemokine secretion (GO:0090197)2.29442981
95regulation of regulated secretory pathway (GO:1903305)2.29275397
96negative regulation of T cell mediated immunity (GO:0002710)2.29208787
97positive regulation of smooth muscle cell migration (GO:0014911)2.28200778
98neutrophil mediated immunity (GO:0002446)2.28176698
99skin morphogenesis (GO:0043589)2.27769389
100regulation of cholesterol storage (GO:0010885)2.25600661
101surfactant homeostasis (GO:0043129)2.25464209
102positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.24442150
103B cell receptor signaling pathway (GO:0050853)2.23683580
104positive regulation of mast cell activation (GO:0033005)2.19972787
105negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.19806938
106cytoskeletal anchoring at plasma membrane (GO:0007016)2.19766526
107positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.19526337
108negative regulation of lipid storage (GO:0010888)2.18891859
109myelin maintenance (GO:0043217)2.18380557
110COPI coating of Golgi vesicle (GO:0048205)2.18308264
111Golgi transport vesicle coating (GO:0048200)2.18308264
112positive regulation of B cell differentiation (GO:0045579)2.17535503
113neutrophil activation (GO:0042119)2.17335090
114nuclear pore complex assembly (GO:0051292)2.16285420
115integrin-mediated signaling pathway (GO:0007229)2.15622437
116glycosphingolipid catabolic process (GO:0046479)2.15164685
117positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.14473826
118response to host (GO:0075136)2.14213339
119response to host defenses (GO:0052200)2.14213339
120response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.14213339
121leukocyte migration involved in inflammatory response (GO:0002523)2.14211965
122stress fiber assembly (GO:0043149)2.13254500
123negative regulation of leukocyte mediated immunity (GO:0002704)2.13254283
124ruffle organization (GO:0031529)2.12686507
125positive regulation of regulated secretory pathway (GO:1903307)2.12568009
126cytoplasmic mRNA processing body assembly (GO:0033962)2.10739010
127positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.09940251
128pathway-restricted SMAD protein phosphorylation (GO:0060389)2.09452983
129regulation of interleukin-12 biosynthetic process (GO:0045075)2.08919489
130response to muramyl dipeptide (GO:0032495)2.08189592
131regulation of macrophage chemotaxis (GO:0010758)2.07842225
132positive regulation of toll-like receptor signaling pathway (GO:0034123)2.07764421
133peptidyl-tyrosine autophosphorylation (GO:0038083)2.07361912
134phagocytosis, engulfment (GO:0006911)2.07212574
135negative regulation of fatty acid transport (GO:2000192)2.06371812
136heterotypic cell-cell adhesion (GO:0034113)2.05921055
137granulocyte activation (GO:0036230)2.05388937
138membrane raft organization (GO:0031579)2.05123534
139adhesion of symbiont to host (GO:0044406)2.04450483
140regulation of membrane protein ectodomain proteolysis (GO:0051043)2.03663094
141glomerular filtration (GO:0003094)2.03460703
142negative regulation of neurotransmitter secretion (GO:0046929)2.01985102
143negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.01807978
144mesodermal cell differentiation (GO:0048333)2.00879303
145pinocytosis (GO:0006907)2.00311179
146negative regulation of B cell proliferation (GO:0030889)1.99912938
147positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)1.99594431
148renal filtration (GO:0097205)1.98644549
149glomerular visceral epithelial cell development (GO:0072015)1.97049273
150positive regulation of antigen processing and presentation (GO:0002579)1.96595359
151wound healing, spreading of cells (GO:0044319)1.96518568
152positive regulation of lipid kinase activity (GO:0090218)1.96066208
153bone remodeling (GO:0046849)1.95946431
154regulation of nitric-oxide synthase biosynthetic process (GO:0051769)1.95739859
155nerve growth factor signaling pathway (GO:0038180)1.94907076
156hepatocyte apoptotic process (GO:0097284)1.94821225
157positive regulation of osteoblast proliferation (GO:0033690)1.94640193
158regulation of antigen processing and presentation (GO:0002577)1.94448145
159response to peptidoglycan (GO:0032494)1.94098164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.73467921
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.08858755
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65568802
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.60527880
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.50304605
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.45356700
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.45296658
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37435265
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.32256129
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09123492
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.08773135
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.07098109
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05514092
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93676823
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93400969
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93051571
17* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.89084779
18TCF7_22412390_ChIP-Seq_EML_Mouse1.83713233
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.83671747
20* WT1_19549856_ChIP-ChIP_CCG9911_Human1.80870983
21TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.79701683
22* GATA2_21666600_ChIP-Seq_HMVEC_Human1.79693895
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79397216
24VDR_24763502_ChIP-Seq_THP-1_Human1.75423082
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74573531
26RUNX_20019798_ChIP-Seq_JUKART_Human1.73399426
27* ELK3_25401928_ChIP-Seq_HUVEC_Human1.73325882
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71560142
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70593283
30VDR_24787735_ChIP-Seq_THP-1_Human1.70588905
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.70190838
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69388148
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69318681
34CJUN_26792858_Chip-Seq_BT549_Human1.68527732
35* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59098893
36VDR_21846776_ChIP-Seq_THP-1_Human1.57789429
37CLOCK_20551151_ChIP-Seq_293T_Human1.56710176
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.56220750
39* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53679242
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.50059946
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49953015
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49953015
43* SPI1_23547873_ChIP-Seq_NB4_Human1.49449253
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48960930
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48304912
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47748932
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44618950
48MAF_26560356_Chip-Seq_TH1_Human1.43906472
49* KDM2B_26808549_Chip-Seq_DND41_Human1.42356069
50* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40798436
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.40044581
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37733836
53MYC_22102868_ChIP-Seq_BL_Human1.37581602
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.36551606
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36177714
56KDM2B_26808549_Chip-Seq_K562_Human1.35289900
57TP53_16413492_ChIP-PET_HCT116_Human1.34871286
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.34375728
59* NCOR1_26117541_ChIP-Seq_K562_Human1.33908399
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.32238423
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31828139
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31768487
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30904858
64* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29272161
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.26319686
66* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25629110
67* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24404611
68* GATA1_19941826_ChIP-Seq_K562_Human1.24154016
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.22492807
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21640431
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20189012
72MYB_26560356_Chip-Seq_TH1_Human1.19896701
73SOX2_20726797_ChIP-Seq_SW620_Human1.19740627
74AHR_22903824_ChIP-Seq_MCF-7_Human1.19640707
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.19264523
76* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19062154
77* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19062154
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18985956
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18641305
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16807541
81MYB_26560356_Chip-Seq_TH2_Human1.16528827
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15801363
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13898131
84GATA1_22025678_ChIP-Seq_K562_Human1.12733932
85* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11428096
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11289411
87PU_27001747_Chip-Seq_BMDM_Mouse1.10844128
88* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10623030
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09297811
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09266221
91TP53_18474530_ChIP-ChIP_U2OS_Human1.08501462
92* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06836757
93* GATA2_19941826_ChIP-Seq_K562_Human1.06655857
94RACK7_27058665_Chip-Seq_MCF-7_Human1.06566392
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06368443
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06354990
97JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06175550
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05489745
99* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04466655
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.04141832
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03733631
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.03558826
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03549495
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02996283
105FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02976893
106RXR_22108803_ChIP-Seq_LS180_Human1.02831224
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02100954
108* TP63_23658742_ChIP-Seq_EP156T_Human1.02061774
109* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01578719
110* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01382315
111SPI1_23127762_ChIP-Seq_K562_Human1.01267741
112IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00676328
113LXR_22158963_ChIP-Seq_LIVER_Mouse0.99817807
114SCL_19346495_ChIP-Seq_HPC-7_Human0.99596435
115UTX_26944678_Chip-Seq_JUKART_Human0.99112268
116* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98816225
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.98543766
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97764997
119* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97637241
120* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97377634
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97056952
122FOXA2_19822575_ChIP-Seq_HepG2_Human0.96914445
123* BRD4_25478319_ChIP-Seq_HGPS_Human0.95487996
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92857221
125RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91761811
126TCF4_18268006_ChIP-ChIP_LS174T_Human0.90046565
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88646889
128KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88529564
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88324237
130NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87407318
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86768324
132CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85844152
133CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85828469
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85236378
135TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85221661
136TBX20_22080862_ChIP-Seq_HEART_Mouse0.84166769
137TBX20_22328084_ChIP-Seq_HEART_Mouse0.84166769
138SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84035620
139AR_21572438_ChIP-Seq_LNCaP_Human0.83899876

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.93608107
2MP0003300_gastrointestinal_ulcer3.26796862
3MP0005451_abnormal_body_composition2.77004934
4MP0000569_abnormal_digit_pigmentation2.76333925
5MP0003303_peritoneal_inflammation2.48158082
6MP0003690_abnormal_glial_cell2.33774689
7MP0003566_abnormal_cell_adhesion2.29044131
8MP0005058_abnormal_lysosome_morphology2.28528978
9MP0008260_abnormal_autophagy2.19991768
10MP0003705_abnormal_hypodermis_morpholog2.06965126
11MP0000920_abnormal_myelination2.04747076
12MP0005275_abnormal_skin_tensile2.03336975
13MP0006082_CNS_inflammation2.03239412
14MP0003191_abnormal_cellular_cholesterol2.02111831
15MP0005167_abnormal_blood-brain_barrier1.97481708
16MP0003950_abnormal_plasma_membrane1.96204813
17MP0004272_abnormal_basement_membrane1.93756869
18MP0003436_decreased_susceptibility_to1.88815931
19MP0001835_abnormal_antigen_presentation1.88623586
20MP0003724_increased_susceptibility_to1.86694566
21MP0003091_abnormal_cell_migration1.85799888
22MP0001958_emphysema1.85126341
23MP0003279_aneurysm1.80611953
24MP0002419_abnormal_innate_immunity1.78646158
25MP0005623_abnormal_meninges_morphology1.75111577
26MP0003828_pulmonary_edema1.70434070
27MP0000858_altered_metastatic_potential1.68123776
28MP0001533_abnormal_skeleton_physiology1.64049315
29MP0003045_fibrosis1.62556100
30MP0003448_altered_tumor_morphology1.61238616
31MP0002998_abnormal_bone_remodeling1.60778268
32MP0005409_darkened_coat_color1.60598332
33MP0001879_abnormal_lymphatic_vessel1.55050991
34MP0000733_abnormal_muscle_development1.54726036
35MP0004883_abnormal_blood_vessel1.52874005
36MP0000767_abnormal_smooth_muscle1.51415884
37MP0005171_absent_coat_pigmentation1.50196667
38MP0005076_abnormal_cell_differentiation1.48762481
39MP0010368_abnormal_lymphatic_system1.48219636
40MP0002166_altered_tumor_susceptibility1.48077157
41MP0005000_abnormal_immune_tolerance1.47571395
42MP0002009_preneoplasia1.45074088
43MP0010678_abnormal_skin_adnexa1.43846296
44MP0005387_immune_system_phenotype1.43394733
45MP0001790_abnormal_immune_system1.43394733
46MP0005397_hematopoietic_system_phenotyp1.42791884
47MP0001545_abnormal_hematopoietic_system1.42791884
48MP0002148_abnormal_hypersensitivity_rea1.42044881
49MP0009278_abnormal_bone_marrow1.41635701
50MP0004510_myositis1.39053364
51MP0003075_altered_response_to1.34437274
52MP0002006_tumorigenesis1.32854013
53MP0000343_altered_response_to1.32853897
54MP0003453_abnormal_keratinocyte_physiol1.31254153
55MP0010352_gastrointestinal_tract_polyps1.29150850
56MP0001851_eye_inflammation1.28213625
57MP0002295_abnormal_pulmonary_circulatio1.26650982
58MP0002452_abnormal_antigen_presenting1.26328711
59MP0005257_abnormal_intraocular_pressure1.19295570
60MP0004947_skin_inflammation1.19009598
61MP0008004_abnormal_stomach_pH1.17335613
62MP0005464_abnormal_platelet_physiology1.17272014
63MP0004185_abnormal_adipocyte_glucose1.16262620
64MP0006054_spinal_hemorrhage1.15499703
65MP0000383_abnormal_hair_follicle1.15368196
66MP0000465_gastrointestinal_hemorrhage1.15300324
67MP0002877_abnormal_melanocyte_morpholog1.14286262
68MP0003329_amyloid_beta_deposits1.13013819
69MP0002138_abnormal_hepatobiliary_system1.12566536
70MP0002254_reproductive_system_inflammat1.12424011
71MP0005025_abnormal_response_to1.10484353
72MP0005023_abnormal_wound_healing1.09002720
73MP0009840_abnormal_foam_cell1.08492534
74MP0002396_abnormal_hematopoietic_system1.08249892
75MP0003172_abnormal_lysosome_physiology1.08007963
76MP0004808_abnormal_hematopoietic_stem1.07773640
77MP0000604_amyloidosis1.07103967
78MP0005503_abnormal_tendon_morphology1.06815778
79MP0001915_intracranial_hemorrhage1.05813345
80MP0004130_abnormal_muscle_cell1.04412151
81MP0010234_abnormal_vibrissa_follicle1.04006567
82MP0002405_respiratory_system_inflammati1.03793201
83MP0002896_abnormal_bone_mineralization1.03096634
84MP0001845_abnormal_inflammatory_respons1.02870192
85MP0005388_respiratory_system_phenotype1.00510333
86MP0002133_abnormal_respiratory_system1.00510333
87MP0005671_abnormal_response_to1.00299607
88MP0003221_abnormal_cardiomyocyte_apopto0.98970522
89MP0002723_abnormal_immune_serum0.98227326
90MP0005390_skeleton_phenotype0.97504585
91MP0002398_abnormal_bone_marrow0.97374936
92MP0001800_abnormal_humoral_immune0.96216850
93MP0005666_abnormal_adipose_tissue0.95864935
94MP0005164_abnormal_response_to0.95353927
95MP0000249_abnormal_blood_vessel0.94840628
96MP0000685_abnormal_immune_system0.94190842
97MP0002168_other_aberrant_phenotype0.93648790
98MP0003252_abnormal_bile_duct0.93120383
99MP0001853_heart_inflammation0.92746197
100MP0005670_abnormal_white_adipose0.92192384
101MP0004134_abnormal_chest_morphology0.91176702
102MP0005166_decreased_susceptibility_to0.91095636
103MP0000716_abnormal_immune_system0.89462411
104MP0004264_abnormal_extraembryonic_tissu0.88782230
105MP0002060_abnormal_skin_morphology0.88657403
106MP0002332_abnormal_exercise_endurance0.87814805
107MP0001819_abnormal_immune_cell0.87602610
108MP0003763_abnormal_thymus_physiology0.87582671
109MP0005375_adipose_tissue_phenotype0.87493964
110MP0009115_abnormal_fat_cell0.86772611
111MP0002420_abnormal_adaptive_immunity0.86637156
112MP0008469_abnormal_protein_level0.86492422
113MP0002971_abnormal_brown_adipose0.85618227
114MP0002933_joint_inflammation0.83025238
115MP0005621_abnormal_cell_physiology0.82353537
116MP0003656_abnormal_erythrocyte_physiolo0.82238792
117MP0009764_decreased_sensitivity_to0.81314118
118MP0002722_abnormal_immune_system0.81122604
119MP0004233_abnormal_muscle_weight0.80151945
120MP0001614_abnormal_blood_vessel0.79721656
121MP0010155_abnormal_intestine_physiology0.79302082
122MP0009785_altered_susceptibility_to0.78852755
123MP0002128_abnormal_blood_circulation0.78191448
124MP0003795_abnormal_bone_structure0.77878892
125MP0002928_abnormal_bile_duct0.75958780

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)3.75430592
2Premature rupture of membranes (HP:0001788)3.55896130
3Cerebral aneurysm (HP:0004944)3.42857754
4Hematochezia (HP:0002573)3.40758817
5Axonal loss (HP:0003447)3.29504278
6Aortic dissection (HP:0002647)3.24704275
7Osteolytic defects of the hand bones (HP:0009699)3.17856375
8Osteolytic defects of the phalanges of the hand (HP:0009771)3.17856375
9Eczematoid dermatitis (HP:0000976)3.15354788
10Arterial tortuosity (HP:0005116)3.13117131
11Vascular tortuosity (HP:0004948)3.12773545
12Polycythemia (HP:0001901)3.08073196
13Thick nail (HP:0001805)3.05881117
14Aortic aneurysm (HP:0004942)3.05588849
15Glomerulonephritis (HP:0000099)3.04151740
16Recurrent abscess formation (HP:0002722)3.02371810
17Myocardial infarction (HP:0001658)2.95927353
18Peritonitis (HP:0002586)2.95223722
19Recurrent bacterial skin infections (HP:0005406)2.81856948
20Increased cerebral lipofuscin (HP:0011813)2.71090572
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.63947251
22Mitral valve prolapse (HP:0001634)2.59272114
23Nephritis (HP:0000123)2.46052440
24Ankyloglossia (HP:0010296)2.45772726
25Shallow orbits (HP:0000586)2.45500031
26Disproportionate tall stature (HP:0001519)2.42995040
27Disinhibition (HP:0000734)2.42912261
28Atrophic scars (HP:0001075)2.41205501
29Orchitis (HP:0100796)2.32769990
30Gastrointestinal infarctions (HP:0005244)2.32323631
31Abnormality of macrophages (HP:0004311)2.32237474
32Increased neuronal autofluorescent lipopigment (HP:0002074)2.30582501
33Optic neuritis (HP:0100653)2.29656095
34Retrobulbar optic neuritis (HP:0100654)2.29656095
35Persistence of primary teeth (HP:0006335)2.28033005
36Peripheral demyelination (HP:0011096)2.27853052
37Hypoplasia of the iris (HP:0007676)2.27280133
38Increased CSF protein (HP:0002922)2.26150301
39Increased connective tissue (HP:0009025)2.24715680
40Autoimmune thrombocytopenia (HP:0001973)2.20001057
41Dilatation of the ascending aorta (HP:0005111)2.17925892
42Spontaneous hematomas (HP:0007420)2.17292422
43Complement deficiency (HP:0004431)2.16822693
44Broad metatarsal (HP:0001783)2.15491716
45Gingival bleeding (HP:0000225)2.13997395
46Recurrent gram-negative bacterial infections (HP:0005420)2.11144048
47Metabolic alkalosis (HP:0200114)2.09488774
48Abnormality of oral frenula (HP:0000190)2.09353393
49Myositis (HP:0100614)2.07673280
50Scapular winging (HP:0003691)2.07317961
51Dysostosis multiplex (HP:0000943)2.06680881
52Segmental peripheral demyelination/remyelination (HP:0003481)2.04745096
53Keratoconjunctivitis sicca (HP:0001097)2.03801848
54Thin bony cortex (HP:0002753)2.03097818
55Neurofibrillary tangles (HP:0002185)2.02513652
56Abnormality of the peritoneum (HP:0002585)1.99101834
57Obstructive lung disease (HP:0006536)1.98898204
58Chronic obstructive pulmonary disease (HP:0006510)1.98898204
59Vertebral compression fractures (HP:0002953)1.97896086
60Abnormality of liposaccharide metabolism (HP:0010968)1.96486545
61Abnormality of glycosphingolipid metabolism (HP:0004343)1.96486545
62Abnormality of glycolipid metabolism (HP:0010969)1.96486545
63Protrusio acetabuli (HP:0003179)1.95487076
64Abnormality of complement system (HP:0005339)1.93180039
65Interstitial pulmonary disease (HP:0006530)1.93164450
66Absent frontal sinuses (HP:0002688)1.92888998
67Prostate neoplasm (HP:0100787)1.92544394
68Recurrent fungal infections (HP:0002841)1.90391724
69Onion bulb formation (HP:0003383)1.89221009
70Slow saccadic eye movements (HP:0000514)1.88887434
71Amyloidosis (HP:0011034)1.87605943
72Mediastinal lymphadenopathy (HP:0100721)1.86642638
73Distal lower limb amyotrophy (HP:0008944)1.86115818
74Arterial thrombosis (HP:0004420)1.85393251
75Increased IgE level (HP:0003212)1.84509226
76Hyporeflexia of lower limbs (HP:0002600)1.84343335
77Vacuolated lymphocytes (HP:0001922)1.84067822
78Epistaxis (HP:0000421)1.84028630
79Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83536582
80Wormian bones (HP:0002645)1.83389255
81Submucous cleft hard palate (HP:0000176)1.81582247
82Decreased motor nerve conduction velocity (HP:0003431)1.80522538
83Gingivitis (HP:0000230)1.80346567
84Urticaria (HP:0001025)1.79958427
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78197349
86Degeneration of the lateral corticospinal tracts (HP:0002314)1.78197349
87Osteomyelitis (HP:0002754)1.77648476
88Macroorchidism (HP:0000053)1.77000134
89Prolonged bleeding time (HP:0003010)1.76758869
90Increased variability in muscle fiber diameter (HP:0003557)1.76679089
91Recurrent skin infections (HP:0001581)1.76172474
92Fragile skin (HP:0001030)1.76157774
93Aneurysm (HP:0002617)1.75948718
94Esophageal varix (HP:0002040)1.75770738
95Spondylolisthesis (HP:0003302)1.74164611
96Soft skin (HP:0000977)1.73793366
97T lymphocytopenia (HP:0005403)1.73703639
98Muscle fiber splitting (HP:0003555)1.73002560
99Fatigue (HP:0012378)1.72764781
100Metaphyseal cupping (HP:0003021)1.72446216
101Hypokalemic alkalosis (HP:0001949)1.72141447
102Loss of speech (HP:0002371)1.71228246
103Abnormality of the frontal sinuses (HP:0002687)1.70392380
104Keratoconjunctivitis (HP:0001096)1.70264863
105Subacute progressive viral hepatitis (HP:0006572)1.69140605
106Colitis (HP:0002583)1.68725582
107Femoral bowing (HP:0002980)1.67919455
108Hypoplastic ischia (HP:0003175)1.66952911
109Abnormality of chloride homeostasis (HP:0011422)1.66866832
110Mucopolysacchariduria (HP:0008155)1.66455514
111Urinary glycosaminoglycan excretion (HP:0003541)1.66455514
112Coarse hair (HP:0002208)1.65981073
113Abnormality of skeletal muscle fiber size (HP:0012084)1.65371433
114Overgrowth (HP:0001548)1.64916525
115Blue sclerae (HP:0000592)1.64261458
116Syringomyelia (HP:0003396)1.64107190
117Spinal cord lesions (HP:0100561)1.64107190
118Abnormality of proline metabolism (HP:0010907)1.63943303
119Hydroxyprolinuria (HP:0003080)1.63943303
120Recurrent cutaneous fungal infections (HP:0011370)1.63742373
121Chronic mucocutaneous candidiasis (HP:0002728)1.63742373
122Periodontitis (HP:0000704)1.63357480
123Cerebral inclusion bodies (HP:0100314)1.62673653
124Papillary thyroid carcinoma (HP:0002895)1.61437914
125Tetany (HP:0001281)1.61174518
126Follicular hyperkeratosis (HP:0007502)1.60361054
127Mitral stenosis (HP:0001718)1.60217590
128Buphthalmos (HP:0000557)1.59587601
129Bone pain (HP:0002653)1.59342028
130Abnormality of the common coagulation pathway (HP:0010990)1.58801744
131Hemoptysis (HP:0002105)1.58471619
132Viral hepatitis (HP:0006562)1.58411463
133Chest pain (HP:0100749)1.58039947
134Increased mean platelet volume (HP:0011877)1.57890402
135Orthostatic hypotension (HP:0001278)1.57237681
136Difficulty running (HP:0009046)1.56495222
137Pathologic fracture (HP:0002756)1.56256575
138Abnormality of the vasculature of the conjunctiva (HP:0008054)1.56114010
139Asymmetry of the thorax (HP:0001555)1.56036878
140Tibial bowing (HP:0002982)1.55829867
141Abnormal platelet volume (HP:0011876)1.55409296
142Cellulitis (HP:0100658)1.55409026
143Termporal pattern (HP:0011008)1.55075022
144Insidious onset (HP:0003587)1.55075022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.78879181
2TGFBR23.54890978
3EPHB13.19570190
4PRPF4B2.99358762
5KSR22.52145078
6ERN12.38519076
7CAMK1D2.33149990
8MAP3K142.31949674
9STK392.21016335
10RIPK12.16350265
11CAMK1G2.15099846
12TTN1.93495441
13TRPM71.72035516
14BMX1.70630357
15MAP3K131.60695856
16MAP3K61.59019956
17BMPR21.58067588
18ZAP701.56562383
19CLK11.54450352
20EPHA31.52069894
21KSR11.47526269
22MAP3K11.46128010
23LATS11.43807315
24JAK11.43311032
25OXSR11.40801216
26STK101.40558542
27WNK11.39400447
28FGFR21.34791642
29STK31.31539632
30PTK61.30593842
31ICK1.28640963
32FRK1.28222411
33MAPK151.27109549
34CSK1.24890789
35TYK21.24589998
36GRK71.24382759
37MET1.23615823
38PDGFRB1.23547579
39NEK91.23027696
40DMPK1.22122654
41YES11.20368683
42FGR1.14111074
43BLK1.13851618
44CDK61.12029902
45TBK11.11973707
46LATS21.09160083
47WNK41.08556281
48MAP3K21.08437692
49IRAK41.07708827
50RAF11.07236981
51PKN11.06888331
52RET1.04988857
53IKBKB1.02629890
54TEC1.02588792
55CSF1R1.00290876
56FGFR30.99987119
57ITK0.99276991
58MAP3K30.99061901
59MARK20.96779668
60FES0.96472294
61PKN20.96442613
62PIK3CA0.96066393
63NUAK10.95493473
64IRAK30.95354967
65MST40.95312399
66CDC42BPA0.94701108
67PRKD10.94254361
68TAOK20.92227577
69PDGFRA0.91531775
70GSK3A0.90438105
71EEF2K0.89247795
72SCYL20.89082916
73BTK0.87587840
74INSRR0.86663087
75PAK20.85463298
76IRAK20.85128977
77JAK20.85109189
78TAOK10.84361828
79HCK0.83687219
80PAK30.80123420
81SGK30.79427492
82IRAK10.77693824
83JAK30.77261197
84STK380.77239936
85RIPK40.77188509
86IKBKE0.76934501
87SGK4940.75099603
88SGK2230.75099603
89CHUK0.72050099
90PAK40.72036223
91PDPK10.71594054
92INSR0.71115034
93DDR20.70943240
94TXK0.70602900
95CDK120.70007835
96SMG10.68652836
97PRKAA20.67953356
98TRIB30.67406640
99EGFR0.67184700
100SYK0.66000848
101MAP3K80.65809333
102ABL10.65258071
103PTK20.63025785
104MAPKAPK50.62026955
105PTK2B0.60562138
106SIK10.59568093
107HIPK20.57931715
108MTOR0.57827921
109LCK0.57347332
110CSNK1A1L0.56942714
111MAP2K30.56391659
112MATK0.55068667
113MAP3K70.52196000
114FYN0.51546165
115MAP3K50.51043443
116MAPK120.50953747
117LRRK20.50744887
118NEK60.50718285
119IGF1R0.50294196
120PRKCH0.50000544
121MOS0.49952750
122SGK20.49925472
123MAP2K20.49773713
124GRK60.49710950
125LYN0.48149975
126PRKD20.47596691
127CDK90.46943019
128PRKG20.46265454
129RPS6KA20.45846358
130MAPK70.45443576
131PDK10.45431041
132STK40.45062614
133MAPKAPK20.44531405
134PIK3CG0.44391984
135MARK30.44061599
136FGFR40.43341976
137SGK10.43232218
138SIK30.42993784
139MAP2K10.42725117
140EPHB20.41655179
141MAP4K10.41464579
142MST1R0.40631171
143PRKCE0.39993284
144NTRK10.39327494

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.03369501
2Staphylococcus aureus infection_Homo sapiens_hsa051502.20308297
3Leishmaniasis_Homo sapiens_hsa051401.81601422
4Osteoclast differentiation_Homo sapiens_hsa043801.79562675
5Malaria_Homo sapiens_hsa051441.74579411
6Non-small cell lung cancer_Homo sapiens_hsa052231.60929166
7Pertussis_Homo sapiens_hsa051331.57267869
8ECM-receptor interaction_Homo sapiens_hsa045121.55802317
9Leukocyte transendothelial migration_Homo sapiens_hsa046701.46553378
10Lysosome_Homo sapiens_hsa041421.45909748
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43486744
12Focal adhesion_Homo sapiens_hsa045101.41089531
13Toxoplasmosis_Homo sapiens_hsa051451.39834607
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.35857770
15VEGF signaling pathway_Homo sapiens_hsa043701.33363276
16Adherens junction_Homo sapiens_hsa045201.32542084
17Amoebiasis_Homo sapiens_hsa051461.31097813
18Nitrogen metabolism_Homo sapiens_hsa009101.30944374
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30251589
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.28478685
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27296945
22Salmonella infection_Homo sapiens_hsa051321.27104707
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26757823
24Prolactin signaling pathway_Homo sapiens_hsa049171.25162334
25Tuberculosis_Homo sapiens_hsa051521.22748958
26Renal cell carcinoma_Homo sapiens_hsa052111.21492111
27B cell receptor signaling pathway_Homo sapiens_hsa046621.20778760
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20593776
29Rheumatoid arthritis_Homo sapiens_hsa053231.19899452
30Endometrial cancer_Homo sapiens_hsa052131.19326981
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18160403
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.17248036
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.16786921
34Proteoglycans in cancer_Homo sapiens_hsa052051.11540280
35Dorso-ventral axis formation_Homo sapiens_hsa043201.10951755
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10673287
37Phagosome_Homo sapiens_hsa041451.10399079
38Chronic myeloid leukemia_Homo sapiens_hsa052201.08560563
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08092696
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07455632
41Chemokine signaling pathway_Homo sapiens_hsa040621.06725141
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05817312
43ErbB signaling pathway_Homo sapiens_hsa040121.05546979
44Bladder cancer_Homo sapiens_hsa052191.04507587
45Graft-versus-host disease_Homo sapiens_hsa053321.04362811
46TNF signaling pathway_Homo sapiens_hsa046681.04091265
47Thyroid cancer_Homo sapiens_hsa052161.02782992
48mTOR signaling pathway_Homo sapiens_hsa041500.99491795
49Platelet activation_Homo sapiens_hsa046110.98074498
50Pancreatic cancer_Homo sapiens_hsa052120.97928002
51Viral myocarditis_Homo sapiens_hsa054160.97334870
52GnRH signaling pathway_Homo sapiens_hsa049120.96947221
53Mineral absorption_Homo sapiens_hsa049780.96843459
54Hematopoietic cell lineage_Homo sapiens_hsa046400.95538186
55Small cell lung cancer_Homo sapiens_hsa052220.95153191
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93391490
57Measles_Homo sapiens_hsa051620.92679661
58HIF-1 signaling pathway_Homo sapiens_hsa040660.92555981
59Endocytosis_Homo sapiens_hsa041440.91752823
60Legionellosis_Homo sapiens_hsa051340.91387724
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89841688
62Prostate cancer_Homo sapiens_hsa052150.89663073
63Steroid biosynthesis_Homo sapiens_hsa001000.89418712
64Complement and coagulation cascades_Homo sapiens_hsa046100.89178747
65Inositol phosphate metabolism_Homo sapiens_hsa005620.87178188
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.85111634
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84162249
68Allograft rejection_Homo sapiens_hsa053300.83794102
69MicroRNAs in cancer_Homo sapiens_hsa052060.82464169
70Shigellosis_Homo sapiens_hsa051310.81767309
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.81621989
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81126666
73Estrogen signaling pathway_Homo sapiens_hsa049150.80893090
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.80841065
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80652231
76Insulin signaling pathway_Homo sapiens_hsa049100.79808747
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77735581
78Autoimmune thyroid disease_Homo sapiens_hsa053200.77407882
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77138797
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76433140
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76218050
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75836462
83Rap1 signaling pathway_Homo sapiens_hsa040150.75796752
84Hepatitis C_Homo sapiens_hsa051600.75562343
85Dilated cardiomyopathy_Homo sapiens_hsa054140.75322327
86Apoptosis_Homo sapiens_hsa042100.73759621
87Type II diabetes mellitus_Homo sapiens_hsa049300.73665222
88Long-term potentiation_Homo sapiens_hsa047200.73553758
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73454811
90Sphingolipid metabolism_Homo sapiens_hsa006000.73182517
91Protein digestion and absorption_Homo sapiens_hsa049740.72685391
92Other glycan degradation_Homo sapiens_hsa005110.72672828
93Influenza A_Homo sapiens_hsa051640.72028523
94Ether lipid metabolism_Homo sapiens_hsa005650.70814755
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.70571626
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.70443762
97Colorectal cancer_Homo sapiens_hsa052100.69813362
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69008418
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68584302
100PPAR signaling pathway_Homo sapiens_hsa033200.68015118
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67902583
102Viral carcinogenesis_Homo sapiens_hsa052030.67815897
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.66667999
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65054651
105Hepatitis B_Homo sapiens_hsa051610.64027922
106T cell receptor signaling pathway_Homo sapiens_hsa046600.63883818
107Axon guidance_Homo sapiens_hsa043600.63140765
108Prion diseases_Homo sapiens_hsa050200.62771159
109African trypanosomiasis_Homo sapiens_hsa051430.61628813
110Insulin resistance_Homo sapiens_hsa049310.61396887
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60990068
112Ras signaling pathway_Homo sapiens_hsa040140.59906804
113Herpes simplex infection_Homo sapiens_hsa051680.59131368
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58926034
115Notch signaling pathway_Homo sapiens_hsa043300.58392589
116Choline metabolism in cancer_Homo sapiens_hsa052310.57311186
117Tight junction_Homo sapiens_hsa045300.55785067
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55629135
119Acute myeloid leukemia_Homo sapiens_hsa052210.55029670
120FoxO signaling pathway_Homo sapiens_hsa040680.54755864
121ABC transporters_Homo sapiens_hsa020100.54578285
122Glioma_Homo sapiens_hsa052140.54331991
123Asthma_Homo sapiens_hsa053100.54006560
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53329287
125TGF-beta signaling pathway_Homo sapiens_hsa043500.53259202
126Antigen processing and presentation_Homo sapiens_hsa046120.50846495
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50586296
128Melanoma_Homo sapiens_hsa052180.50385535
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50033765

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »