PIEZO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.47354035
2COPI coating of Golgi vesicle (GO:0048205)4.47354035
3negative regulation of erythrocyte differentiation (GO:0045647)4.31696329
4mannose metabolic process (GO:0006013)4.25733055
5cell adhesion mediated by integrin (GO:0033627)4.01856822
6apoptotic cell clearance (GO:0043277)3.92680029
7wound healing, spreading of epidermal cells (GO:0035313)3.90946851
8endodermal cell differentiation (GO:0035987)3.86903645
9desmosome organization (GO:0002934)3.83482647
10regulation of histone H3-K27 methylation (GO:0061085)3.58138107
11negative regulation of cell size (GO:0045792)3.53629066
12protein heterotrimerization (GO:0070208)3.44499504
13negative regulation of fatty acid transport (GO:2000192)3.37749199
14activation of Rac GTPase activity (GO:0032863)3.30145233
15basement membrane organization (GO:0071711)3.29258726
16regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.28842698
17positive regulation of endothelial cell apoptotic process (GO:2000353)3.24691944
18cell-substrate junction assembly (GO:0007044)3.20245685
19insulin-like growth factor receptor signaling pathway (GO:0048009)3.17592534
20skin morphogenesis (GO:0043589)3.17062558
21embryonic process involved in female pregnancy (GO:0060136)3.14479739
22positive regulation of Cdc42 GTPase activity (GO:0043089)3.14367201
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.13918061
24vascular endothelial growth factor signaling pathway (GO:0038084)3.13301585
25retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.12910506
26collagen fibril organization (GO:0030199)3.11978816
27regulation of glucose import in response to insulin stimulus (GO:2001273)3.10985617
28atrioventricular valve morphogenesis (GO:0003181)3.06618098
29chondrocyte proliferation (GO:0035988)3.05221942
30cytoskeletal anchoring at plasma membrane (GO:0007016)3.04308260
31positive regulation of p38MAPK cascade (GO:1900745)3.03004829
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.01377031
33protein retention in ER lumen (GO:0006621)3.00989279
34plasma membrane repair (GO:0001778)3.00831255
35heterochromatin organization (GO:0070828)2.99169757
36response to laminar fluid shear stress (GO:0034616)2.97839248
37wound healing, spreading of cells (GO:0044319)2.97811919
38positive regulation of keratinocyte differentiation (GO:0045618)2.95633805
39regulation of early endosome to late endosome transport (GO:2000641)2.95007431
40regulation of SMAD protein import into nucleus (GO:0060390)2.94514439
41substrate-dependent cell migration (GO:0006929)2.93314075
42neuron projection extension involved in neuron projection guidance (GO:1902284)2.92673745
43axon extension involved in axon guidance (GO:0048846)2.92673745
44maternal placenta development (GO:0001893)2.91629647
45positive regulation of SMAD protein import into nucleus (GO:0060391)2.90717113
46epithelial cell differentiation involved in prostate gland development (GO:0060742)2.90240232
47vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.89227406
48positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.86052584
49nuclear pore complex assembly (GO:0051292)2.81509495
50adherens junction assembly (GO:0034333)2.81241483
51apoptotic process involved in morphogenesis (GO:0060561)2.80773835
52low-density lipoprotein particle clearance (GO:0034383)2.80208866
53cellular response to interferon-alpha (GO:0035457)2.79089454
54positive regulation by organism of defense response of other organism involved in symbiotic interact2.79019002
55modulation by symbiont of host immune response (GO:0052553)2.79019002
56positive regulation by symbiont of host defense response (GO:0052509)2.79019002
57modulation by symbiont of host defense response (GO:0052031)2.79019002
58modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.79019002
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.79019002
60response to fluid shear stress (GO:0034405)2.77897449
61negative regulation of smooth muscle cell migration (GO:0014912)2.77676983
62regulation of hippo signaling (GO:0035330)2.76595796
63epithelial cell-cell adhesion (GO:0090136)2.74401019
64positive regulation of histone deacetylation (GO:0031065)2.72799209
65activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.72114937
66regulation of mammary gland epithelial cell proliferation (GO:0033599)2.71965879
67proline biosynthetic process (GO:0006561)2.69922601
68substrate adhesion-dependent cell spreading (GO:0034446)2.68897236
69branching involved in mammary gland duct morphogenesis (GO:0060444)2.65501948
70pentose-phosphate shunt (GO:0006098)2.65449120
71negative regulation of viral release from host cell (GO:1902187)2.64614399
72positive regulation of nuclease activity (GO:0032075)2.60919536
73mRNA transcription (GO:0009299)2.60664093
74stress fiber assembly (GO:0043149)2.60535976
75regulation of translational fidelity (GO:0006450)2.58619167
76regulation of extracellular matrix disassembly (GO:0010715)2.58476873
77embryonic eye morphogenesis (GO:0048048)2.57346421
78positive regulation of receptor recycling (GO:0001921)2.57194393
79planar cell polarity pathway involved in neural tube closure (GO:0090179)2.57016567
80regulation of fatty acid beta-oxidation (GO:0031998)2.56973003
81positive regulation of blood vessel endothelial cell migration (GO:0043536)2.56397536
82positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.56372974
83regulation of tight junction assembly (GO:2000810)2.55081169
84collagen metabolic process (GO:0032963)2.54146891
85glucose catabolic process (GO:0006007)2.52927407
86positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.52135445
87regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.49825425
88barbed-end actin filament capping (GO:0051016)2.49460127
89hemidesmosome assembly (GO:0031581)2.49272697
90collagen catabolic process (GO:0030574)2.48988874
91endoplasmic reticulum unfolded protein response (GO:0030968)2.48624663
92hippo signaling (GO:0035329)2.48563781
93cell migration involved in sprouting angiogenesis (GO:0002042)2.48550606
94cortical actin cytoskeleton organization (GO:0030866)2.48292249
95nuclear pore organization (GO:0006999)2.47718735
96NLS-bearing protein import into nucleus (GO:0006607)2.47229300
97cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.47218028
98focal adhesion assembly (GO:0048041)2.45736543
99cell-substrate adherens junction assembly (GO:0007045)2.45736543
100glomerular visceral epithelial cell development (GO:0072015)2.45268439
101hypotonic response (GO:0006971)2.43665368
102blood vessel endothelial cell migration (GO:0043534)2.42415552
103endothelial cell morphogenesis (GO:0001886)2.40732766
104regulation of mitotic spindle organization (GO:0060236)2.40731057
105regulation of apoptotic process involved in morphogenesis (GO:1902337)2.39047517
106positive regulation of gamma-delta T cell activation (GO:0046645)2.38663748
107hyaluronan catabolic process (GO:0030214)2.37975994
108ER-nucleus signaling pathway (GO:0006984)2.37837921
109regulation of interleukin-12 biosynthetic process (GO:0045075)2.37569305
110positive regulation of natural killer cell differentiation (GO:0032825)2.37328230
111negative regulation of interleukin-12 production (GO:0032695)2.37165500
112membrane protein ectodomain proteolysis (GO:0006509)2.36707482
113extracellular matrix disassembly (GO:0022617)2.36307639
114multicellular organismal macromolecule metabolic process (GO:0044259)2.36264080
115regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.35972030
116protein localization to endosome (GO:0036010)2.35773479
117morphogenesis of an endothelium (GO:0003159)2.35420858
118endothelial tube morphogenesis (GO:0061154)2.35420858
119T cell apoptotic process (GO:0070231)2.34984872
120retina vasculature morphogenesis in camera-type eye (GO:0061299)2.34441397
121polarized epithelial cell differentiation (GO:0030859)2.34005580
122regulation of nuclease activity (GO:0032069)2.33656754
123response to water (GO:0009415)2.33022434
124regulation of water loss via skin (GO:0033561)2.32585637
125endothelial cell chemotaxis (GO:0035767)2.32275485
126integrin-mediated signaling pathway (GO:0007229)2.32156292
127surfactant homeostasis (GO:0043129)2.31898632
128response to muramyl dipeptide (GO:0032495)2.31698556
129renal filtration (GO:0097205)2.29302410
130cellular response to epidermal growth factor stimulus (GO:0071364)2.28725482
131modulation by symbiont of host cellular process (GO:0044068)2.28631430
132dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.27072278
133mammary gland epithelial cell proliferation (GO:0033598)2.26659857
134cellular response to unfolded protein (GO:0034620)2.26609774
135pinocytosis (GO:0006907)2.26190402
136regulation of endothelial cell chemotaxis (GO:2001026)2.25870720
137mRNA transcription from RNA polymerase II promoter (GO:0042789)2.25818951
138multicellular organismal catabolic process (GO:0044243)2.24360932
139antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.23316420
140antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.23316420
141negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.23235317
142positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.23095487
143pore complex assembly (GO:0046931)2.22749328
144semaphorin-plexin signaling pathway (GO:0071526)2.22369149
145regulation of p38MAPK cascade (GO:1900744)2.22271820
146regulation of gene silencing by RNA (GO:0060966)2.22092504
147regulation of posttranscriptional gene silencing (GO:0060147)2.22092504
148regulation of gene silencing by miRNA (GO:0060964)2.22092504
149mitotic chromosome condensation (GO:0007076)2.21179585
150positive regulation of protein deacetylation (GO:0090312)2.20464673
151germ cell migration (GO:0008354)2.20240016
152positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.20090595
153positive regulation of osteoblast proliferation (GO:0033690)2.19744041
154positive regulation of extracellular matrix organization (GO:1903055)2.19469800
155glucose 6-phosphate metabolic process (GO:0051156)2.19435726
156positive regulation of endothelial cell migration (GO:0010595)2.19412749
157antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.19289301
158positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.18816689
159multicellular organismal metabolic process (GO:0044236)2.18693837
160cellular response to vitamin (GO:0071295)2.18373886
161thymic T cell selection (GO:0045061)2.17375547
1623-UTR-mediated mRNA stabilization (GO:0070935)2.17303387
163embryonic camera-type eye morphogenesis (GO:0048596)2.15226717
164UV protection (GO:0009650)2.14763791
165vesicle coating (GO:0006901)2.14452971
166spliceosomal tri-snRNP complex assembly (GO:0000244)2.14129604
167NADPH regeneration (GO:0006740)2.13776304
168regulation of type I interferon-mediated signaling pathway (GO:0060338)2.13617302

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.18453800
2E2F7_22180533_ChIP-Seq_HELA_Human4.03390545
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.99727686
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.94565737
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.05500061
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.81608175
7ZNF263_19887448_ChIP-Seq_K562_Human2.63273640
8MYC_22102868_ChIP-Seq_BL_Human2.43325726
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.37752346
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.28525929
11VDR_21846776_ChIP-Seq_THP-1_Human2.19738466
12RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.18280841
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.02697995
14CLOCK_20551151_ChIP-Seq_293T_Human2.02256111
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97116522
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96373252
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.95631298
18IRF8_22096565_ChIP-ChIP_GC-B_Human1.90539342
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89454745
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88727481
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84643007
22TCF7_22412390_ChIP-Seq_EML_Mouse1.84154025
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.82016209
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81344009
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77280323
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76362520
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.76290675
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75507553
29KDM2B_26808549_Chip-Seq_DND41_Human1.73574764
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72954153
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.71832511
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68280112
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64326430
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62420545
35KDM2B_26808549_Chip-Seq_K562_Human1.60156289
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59752279
37ATF3_27146783_Chip-Seq_COLON_Human1.59629599
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59026111
39MAF_26560356_Chip-Seq_TH1_Human1.56584623
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53400304
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.52438416
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52107354
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.51190052
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50781736
45VDR_24763502_ChIP-Seq_THP-1_Human1.49197704
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46878175
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46164614
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46164614
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45464809
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44759742
51RACK7_27058665_Chip-Seq_MCF-7_Human1.43642899
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42294177
53RUNX1_27514584_Chip-Seq_MCF-7_Human1.41358607
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36685618
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36201492
56UTX_26944678_Chip-Seq_JUKART_Human1.34714907
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33844135
58TFEB_21752829_ChIP-Seq_HELA_Human1.33602119
59BRD4_25478319_ChIP-Seq_HGPS_Human1.33341127
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32821057
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32304300
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32051221
63TP53_22127205_ChIP-Seq_IMR90_Human1.31567558
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29256092
65NCOR1_26117541_ChIP-Seq_K562_Human1.28855962
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.28532716
67SPI1_23127762_ChIP-Seq_K562_Human1.26459921
68P68_20966046_ChIP-Seq_HELA_Human1.26352677
69EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25441407
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23869114
71LXR_22292898_ChIP-Seq_THP-1_Human1.23811376
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.23665513
73UBF1/2_26484160_Chip-Seq_HMECs_Human1.23351798
74ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.22287265
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.21622260
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.20991501
77SMC4_20622854_ChIP-Seq_HELA_Human1.20545533
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20212559
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.20212354
80MAF_26560356_Chip-Seq_TH2_Human1.20032301
81SCL_19346495_ChIP-Seq_HPC-7_Human1.18388655
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18074404
83PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17974847
84CREB1_26743006_Chip-Seq_LNCaP_Human1.17729377
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.16824517
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16754887
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16324075
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16206592
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16034827
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14796896
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13642150
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13522952
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13211033
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12494401
95AR_21909140_ChIP-Seq_LNCAP_Human1.11883445
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11637978
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11622856
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11090372
99MYB_26560356_Chip-Seq_TH1_Human1.11065199
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10511926
101KDM2B_26808549_Chip-Seq_JURKAT_Human1.09701145
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08979163
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08532470
104FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08324619
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.08158793
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07869917
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06973543
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06856798
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06506855
110MYB_26560356_Chip-Seq_TH2_Human1.06245305
111ERG_21242973_ChIP-ChIP_JURKAT_Human1.04583308
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03952312
113GATA1_19941826_ChIP-Seq_K562_Human1.03817083
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03381120
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03187783
116FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03027925
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02723286
118NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02568566
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01424036
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01219057
121P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00582589
122JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00312030
123PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99012716
124ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98750019
125PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98698640
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98591584
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98468163
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.98381621
129SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98355896
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98140643
131SPI1_23547873_ChIP-Seq_NB4_Human0.97818882
132SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97534461
133UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97347620
134E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94704149
135ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94590972
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.94532265

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.63495120
2MP0003705_abnormal_hypodermis_morpholog3.91017118
3MP0010352_gastrointestinal_tract_polyps2.90831206
4MP0003566_abnormal_cell_adhesion2.90362866
5MP0005275_abnormal_skin_tensile2.65006583
6MP0010234_abnormal_vibrissa_follicle2.53768393
7MP0003279_aneurysm2.52844290
8MP0001958_emphysema2.38960248
9MP0005451_abnormal_body_composition2.35001409
10MP0005076_abnormal_cell_differentiation2.22531925
11MP0000569_abnormal_digit_pigmentation2.11481959
12MP0002796_impaired_skin_barrier2.10412229
13MP0005623_abnormal_meninges_morphology2.08811724
14MP0003091_abnormal_cell_migration2.07899650
15MP0005023_abnormal_wound_healing2.04466594
16MP0003300_gastrointestinal_ulcer2.02605926
17MP0005257_abnormal_intraocular_pressure2.02357438
18MP0004272_abnormal_basement_membrane2.01389097
19MP0009278_abnormal_bone_marrow2.01162118
20MP0003303_peritoneal_inflammation1.91510579
21MP0005503_abnormal_tendon_morphology1.84456791
22MP0003191_abnormal_cellular_cholesterol1.82948782
23MP0000733_abnormal_muscle_development1.82923586
24MP0005409_darkened_coat_color1.82867450
25MP0010307_abnormal_tumor_latency1.67549587
26MP0004233_abnormal_muscle_weight1.62178076
27MP0008260_abnormal_autophagy1.61823841
28MP0005501_abnormal_skin_physiology1.60591005
29MP0009840_abnormal_foam_cell1.55976265
30MP0004858_abnormal_nervous_system1.55767689
31MP0006054_spinal_hemorrhage1.51306954
32MP0002877_abnormal_melanocyte_morpholog1.49041355
33MP0005058_abnormal_lysosome_morphology1.45405151
34MP0003448_altered_tumor_morphology1.44372556
35MP0000767_abnormal_smooth_muscle1.41493523
36MP0002060_abnormal_skin_morphology1.39617029
37MP0004264_abnormal_extraembryonic_tissu1.39506293
38MP0003436_decreased_susceptibility_to1.38350576
39MP0004808_abnormal_hematopoietic_stem1.35669553
40MP0000858_altered_metastatic_potential1.32130853
41MP0005666_abnormal_adipose_tissue1.28718011
42MP0000678_abnormal_parathyroid_gland1.24104207
43MP0005397_hematopoietic_system_phenotyp1.21509411
44MP0001545_abnormal_hematopoietic_system1.21509411
45MP0001243_abnormal_dermal_layer1.21471153
46MP0002933_joint_inflammation1.20420224
47MP0003045_fibrosis1.20092703
48MP0003172_abnormal_lysosome_physiology1.19356122
49MP0001915_intracranial_hemorrhage1.17908741
50MP0001216_abnormal_epidermal_layer1.17774906
51MP0002396_abnormal_hematopoietic_system1.14638288
52MP0000750_abnormal_muscle_regeneration1.14613589
53MP0000685_abnormal_immune_system1.14587348
54MP0004947_skin_inflammation1.14450532
55MP0003763_abnormal_thymus_physiology1.13415702
56MP0005508_abnormal_skeleton_morphology1.13389516
57MP0004381_abnormal_hair_follicle1.10320702
58MP0001533_abnormal_skeleton_physiology1.09739558
59MP0010368_abnormal_lymphatic_system1.09273675
60MP0004185_abnormal_adipocyte_glucose1.08320207
61MP0000467_abnormal_esophagus_morphology1.07554163
62MP0009931_abnormal_skin_appearance1.07500228
63MP0002998_abnormal_bone_remodeling1.06566132
64MP0000013_abnormal_adipose_tissue1.03125308
65MP0004197_abnormal_fetal_growth/weight/1.02373230
66MP0005390_skeleton_phenotype1.00689889
67MP0001849_ear_inflammation1.00537961
68MP0002925_abnormal_cardiovascular_devel1.00535289
69MP0004510_myositis0.99484987
70MP0001873_stomach_inflammation0.98286247
71MP0004782_abnormal_surfactant_physiolog0.97318112
72MP0002166_altered_tumor_susceptibility0.96074503
73MP0002098_abnormal_vibrissa_morphology0.95723768
74MP0002086_abnormal_extraembryonic_tissu0.95137450
75MP0003828_pulmonary_edema0.94278191
76MP0003453_abnormal_keratinocyte_physiol0.93400462
77MP0000579_abnormal_nail_morphology0.93277465
78MP0001879_abnormal_lymphatic_vessel0.92075874
79MP0003984_embryonic_growth_retardation0.91798600
80MP0002405_respiratory_system_inflammati0.91502040
81MP0002088_abnormal_embryonic_growth/wei0.91267423
82MP0001614_abnormal_blood_vessel0.91110679
83MP0006138_congestive_heart_failure0.90968771
84MP0010630_abnormal_cardiac_muscle0.89542324
85MP0010030_abnormal_orbit_morphology0.88729151
86MP0003111_abnormal_nucleus_morphology0.88351663
87MP0000350_abnormal_cell_proliferation0.87728329
88MP0002128_abnormal_blood_circulation0.86514282
89MP0002419_abnormal_innate_immunity0.86405472
90MP0009384_cardiac_valve_regurgitation0.86047660
91MP0002249_abnormal_larynx_morphology0.85196301
92MP0002896_abnormal_bone_mineralization0.84658262
93MP0000343_altered_response_to0.84479169
94MP0002452_abnormal_antigen_presenting0.83828163
95MP0001730_embryonic_growth_arrest0.83691203
96MP0009333_abnormal_splenocyte_physiolog0.83453726
97MP0000537_abnormal_urethra_morphology0.83402572
98MP0005380_embryogenesis_phenotype0.83099535
99MP0001672_abnormal_embryogenesis/_devel0.83099535
100MP0005621_abnormal_cell_physiology0.82450760
101MP0001790_abnormal_immune_system0.81561795
102MP0005387_immune_system_phenotype0.81561795
103MP0000377_abnormal_hair_follicle0.81266206
104MP0001835_abnormal_antigen_presentation0.81058700
105MP0002168_other_aberrant_phenotype0.80849118
106MP0010771_integument_phenotype0.80816992
107MP0008007_abnormal_cellular_replicative0.80102272
108MP0000751_myopathy0.79910285
109MP0000490_abnormal_crypts_of0.79805930
110MP0003115_abnormal_respiratory_system0.78771544
111MP0002970_abnormal_white_adipose0.78639478
112MP0005464_abnormal_platelet_physiology0.77647208
113MP0004084_abnormal_cardiac_muscle0.77539976
114MP0009053_abnormal_anal_canal0.77463397
115MP0002089_abnormal_postnatal_growth/wei0.77415222
116MP0000003_abnormal_adipose_tissue0.76582283
117MP0003795_abnormal_bone_structure0.76130466
118MP0002009_preneoplasia0.75505755
119MP0005375_adipose_tissue_phenotype0.75344851
120MP0002295_abnormal_pulmonary_circulatio0.75290645
121MP0000428_abnormal_craniofacial_morphol0.75009192
122MP0002113_abnormal_skeleton_development0.74657439
123MP0004087_abnormal_muscle_fiber0.74583823
124MP0002006_tumorigenesis0.74337793
125MP0000759_abnormal_skeletal_muscle0.72806264
126MP0003077_abnormal_cell_cycle0.72691330
127MP0000627_abnormal_mammary_gland0.72648173
128MP0001348_abnormal_lacrimal_gland0.71923597
129MP0005000_abnormal_immune_tolerance0.71663737
130MP0006082_CNS_inflammation0.71635674
131MP0001175_abnormal_lung_morphology0.71323282
132MP0000371_diluted_coat_color0.70925232
133MP0005670_abnormal_white_adipose0.70910653
134MP0003950_abnormal_plasma_membrane0.70215826
135MP0002084_abnormal_developmental_patter0.70174211
136MP0002080_prenatal_lethality0.68693066
137MP0005083_abnormal_biliary_tract0.68683545
138MP0005384_cellular_phenotype0.66944250
139MP0001881_abnormal_mammary_gland0.66712315

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.55419250
2Premature rupture of membranes (HP:0001788)5.21772882
3Cerebral aneurysm (HP:0004944)4.17630764
4Ankle contracture (HP:0006466)3.85760868
5Shallow orbits (HP:0000586)3.83599721
6Cervical subluxation (HP:0003308)3.64844837
7Peritonitis (HP:0002586)3.44536801
8Increased connective tissue (HP:0009025)3.31655369
9Hyperacusis (HP:0010780)3.23716871
10Aortic dissection (HP:0002647)3.20022710
11Atrophic scars (HP:0001075)3.05054297
12Aortic aneurysm (HP:0004942)3.01596330
13Dilatation of the ascending aorta (HP:0005111)2.95508773
14Genu recurvatum (HP:0002816)2.94114685
15Ulnar bowing (HP:0003031)2.93081201
16Mitral valve prolapse (HP:0001634)2.86971183
17Osteolytic defects of the hand bones (HP:0009699)2.75866737
18Osteolytic defects of the phalanges of the hand (HP:0009771)2.75866737
19Increased density of long bones (HP:0006392)2.74430355
20Vertebral compression fractures (HP:0002953)2.68032609
21Distal upper limb amyotrophy (HP:0007149)2.67558313
22Upper limb amyotrophy (HP:0009129)2.67558313
23J-shaped sella turcica (HP:0002680)2.65484705
24Wrist flexion contracture (HP:0001239)2.64949418
25Fragile skin (HP:0001030)2.63336816
26Broad metatarsal (HP:0001783)2.63290109
27Bladder diverticulum (HP:0000015)2.61474837
28Radial bowing (HP:0002986)2.48747333
29Distal lower limb amyotrophy (HP:0008944)2.48178843
30Soft skin (HP:0000977)2.47237722
31Blue sclerae (HP:0000592)2.41158992
32Asymmetry of the thorax (HP:0001555)2.38890551
33Wormian bones (HP:0002645)2.38055289
34Abnormality of oral frenula (HP:0000190)2.32789612
35Spinal rigidity (HP:0003306)2.30511298
36Aneurysm (HP:0002617)2.30511269
37Achilles tendon contracture (HP:0001771)2.27770327
38Ankyloglossia (HP:0010296)2.26622304
39Difficulty climbing stairs (HP:0003551)2.24032047
40Hand muscle atrophy (HP:0009130)2.23202135
41Bowed forearm bones (HP:0003956)2.22353259
42Bowing of the arm (HP:0006488)2.22353259
43Abnormality of the acetabulum (HP:0003170)2.22338316
44Abnormality of the peritoneum (HP:0002585)2.20331592
45Syringomyelia (HP:0003396)2.18498607
46Spinal cord lesions (HP:0100561)2.18498607
47Abnormality of the calcaneus (HP:0008364)2.17335271
48Persistence of primary teeth (HP:0006335)2.15796712
49Type 1 muscle fiber predominance (HP:0003803)2.14141671
50Sparse lateral eyebrow (HP:0005338)2.12933742
51Arterial tortuosity (HP:0005116)2.12580483
52Absent frontal sinuses (HP:0002688)2.11560923
53Thin bony cortex (HP:0002753)2.08451966
54Flat acetabular roof (HP:0003180)2.07566539
55Advanced eruption of teeth (HP:0006288)2.05164928
56Obstructive sleep apnea (HP:0002870)2.04704748
57Short nail (HP:0001799)2.03059857
58Coxa vara (HP:0002812)2.02757630
59Neonatal short-limb short stature (HP:0008921)2.01654185
60Short 4th metacarpal (HP:0010044)2.00937251
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00937251
62Camptodactyly of toe (HP:0001836)2.00294731
63Selective tooth agenesis (HP:0001592)2.00031894
64Abnormality of the Achilles tendon (HP:0005109)1.99702679
65Hemorrhage of the eye (HP:0011885)1.99701373
66Dysostosis multiplex (HP:0000943)1.99488463
67Bowel diverticulosis (HP:0005222)1.98907290
68Long palpebral fissure (HP:0000637)1.98824639
69Natal tooth (HP:0000695)1.97066055
70Premature skin wrinkling (HP:0100678)1.95974107
71Tibial bowing (HP:0002982)1.94552599
72Abnormality of the distal phalanges of the toes (HP:0010182)1.93917393
73Slender build (HP:0001533)1.93308305
74Stridor (HP:0010307)1.93172633
75Mucopolysacchariduria (HP:0008155)1.92855811
76Urinary glycosaminoglycan excretion (HP:0003541)1.92855811
77Increased variability in muscle fiber diameter (HP:0003557)1.92831444
78Biconcave vertebral bodies (HP:0004586)1.92726079
79Hematochezia (HP:0002573)1.90818233
80Abnormality of the thoracic spine (HP:0100711)1.90262542
81Spondylolisthesis (HP:0003302)1.89415379
82Interstitial pulmonary disease (HP:0006530)1.88435810
83Broad face (HP:0000283)1.86004626
84Elbow flexion contracture (HP:0002987)1.85811267
85Mesomelia (HP:0003027)1.84435363
86Myocardial infarction (HP:0001658)1.83250508
87Esophageal varix (HP:0002040)1.82610688
88Abnormality of dentin (HP:0010299)1.82129411
89Disproportionate tall stature (HP:0001519)1.82045471
90Increased mean platelet volume (HP:0011877)1.81785503
91Deformed sella turcica (HP:0002681)1.81746188
92Joint laxity (HP:0001388)1.80590325
93Urethral obstruction (HP:0000796)1.80446021
94Increased cerebral lipofuscin (HP:0011813)1.80396956
95Metaphyseal cupping (HP:0003021)1.80027464
96Abnormality of the fingertips (HP:0001211)1.79543355
97Abnormality of polysaccharide metabolism (HP:0011012)1.77148133
98Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77148133
99Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77148133
100Joint stiffness (HP:0001387)1.76140756
101Scapular winging (HP:0003691)1.75669642
102Aortic regurgitation (HP:0001659)1.74863872
103Patellar dislocation (HP:0002999)1.74615043
104Abnormal platelet volume (HP:0011876)1.73073436
105Polycythemia (HP:0001901)1.72515085
106Long toe (HP:0010511)1.72224582
107Joint contractures involving the joints of the feet (HP:0100492)1.72014350
108Flexion contracture of toe (HP:0005830)1.72014350
109Abnormal vertebral ossification (HP:0100569)1.71994409
110Milia (HP:0001056)1.71625341
111Deviation of the hallux (HP:0010051)1.71496186
112Cellulitis (HP:0100658)1.71388506
113Generalized amyotrophy (HP:0003700)1.71052470
114High pitched voice (HP:0001620)1.71019946
115Ectopia lentis (HP:0001083)1.70370626
116Abnormality of skeletal muscle fiber size (HP:0012084)1.70259147
117Lower limb amyotrophy (HP:0007210)1.70149741
118Abnormal ossification of hand bones (HP:0005921)1.70130639
119Mitral regurgitation (HP:0001653)1.70049456
120Mildly elevated creatine phosphokinase (HP:0008180)1.69014235
121Trismus (HP:0000211)1.68891813
122Hypoplastic ischia (HP:0003175)1.68048552
123Long eyelashes (HP:0000527)1.67922312
124Hallux valgus (HP:0001822)1.67571402
125Frequent falls (HP:0002359)1.67406587
126Vascular tortuosity (HP:0004948)1.66729525
127Abnormality of the distal phalanx of the thumb (HP:0009617)1.66634254
128Micronodular cirrhosis (HP:0001413)1.65978807
129Abnormality of the radial head (HP:0003995)1.65847615
130Centrally nucleated skeletal muscle fibers (HP:0003687)1.62879568
131Insomnia (HP:0100785)1.62318484
132Abnormality of the odontoid process (HP:0003310)1.62277881
133Venous abnormality (HP:0002624)1.61341453
134Autoimmune thrombocytopenia (HP:0001973)1.61082679
135Muscle fiber splitting (HP:0003555)1.61039983
136Follicular hyperkeratosis (HP:0007502)1.60506074
137Easy fatigability (HP:0003388)1.59963959
138Fused cervical vertebrae (HP:0002949)1.59472316
139Distal lower limb muscle weakness (HP:0009053)1.59170721
140Subacute progressive viral hepatitis (HP:0006572)1.58898805
141Platyspondyly (HP:0000926)1.58313331
142Broad long bones (HP:0005622)1.57541382
143Dislocated radial head (HP:0003083)1.56961304
144Hyperextensible skin (HP:0000974)1.56680723
145Nonimmune hydrops fetalis (HP:0001790)1.55143974
146Broad thumb (HP:0011304)1.54451492
147Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.54205394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.98927500
2TTN3.97409086
3CDK123.27737540
4PKN23.24630480
5SMG13.15084510
6IRAK32.64597898
7ERN12.61217354
8EEF2K2.59599627
9PRPF4B2.48265673
10EPHA22.25220615
11MST1R2.01589493
12DDR21.99586279
13MAP3K101.96906129
14PTK61.93088084
15PDGFRA1.92038494
16BMX1.91696215
17RIPK11.89212389
18STK101.74199129
19CAMK1D1.72798816
20SIK11.63651688
21PAK41.61096705
22LATS11.60631356
23LRRK21.51762736
24TGFBR21.47978287
25RPS6KA41.45959169
26TRPM71.43219187
27PAK21.42140385
28MTOR1.41026148
29MAP4K11.40717814
30MAP2K31.40101181
31JAK31.30619171
32PTK21.30041314
33CAMK1G1.29205321
34MAP3K131.28073325
35EPHB11.27475541
36STK31.21704013
37NEK21.19300893
38TBK11.18987836
39PRKD21.17931754
40KIT1.14644617
41CDK61.13079430
42MAP3K31.12224144
43LATS21.06690637
44TYK21.04852863
45ICK1.04803131
46CDC42BPA1.04105903
47MAP3K141.00116933
48PDGFRB0.98918818
49MAP3K80.96449175
50PIM20.95840159
51SCYL20.94815988
52MAP3K60.94073989
53CHUK0.93930880
54DMPK0.92845714
55KSR20.92002532
56ZAP700.91227620
57BRD40.90611466
58JAK10.90517314
59NME20.86937483
60TAOK20.86363291
61MARK20.85576167
62CSK0.85083989
63PDPK10.84870977
64SIK20.84300858
65MAP2K20.83524467
66PIM10.83416189
67HCK0.82621969
68CDK40.81789174
69KDR0.81471360
70FLT30.78560867
71MET0.78218566
72MAP3K10.77296548
73IKBKB0.77278399
74MAPK110.75471832
75TESK20.74426403
76TGFBR10.74133739
77PRKD30.73840735
78ALK0.70740478
79CSF1R0.70697561
80NTRK10.69751176
81RPS6KB20.68014312
82EPHB20.66351087
83HIPK20.64800932
84CDK70.64130640
85RET0.63395818
86STK380.63355742
87PTK2B0.62256512
88FGFR10.61686727
89NEK90.61299767
90FGFR40.61228425
91MOS0.60926817
92MARK30.58351529
93STK40.58177723
94LMTK20.57290720
95MAP3K70.57218754
96RIPK40.57218015
97IRAK20.56857717
98IRAK40.56855658
99CDC70.54753570
100ILK0.52364906
101GRK60.52158355
102EGFR0.50047382
103MAP3K110.49586969
104MAP3K20.47994016
105FGFR30.47705974
106RPS6KA60.47036439
107ARAF0.46910728
108INSR0.46175562
109PRKG20.45485635
110TAOK10.45323147
111MAP2K10.45237685
112RPS6KC10.44717307
113RPS6KL10.44717307
114PAK10.43045071
115PDK10.41983524
116TESK10.41797515
117TTK0.41676579
118MAPKAPK20.41590980
119CDK90.41378611
120ABL10.40774905
121MELK0.40261920
122CDK80.40217173
123MAPKAPK30.39957154
124BTK0.39623354
125ITK0.39368252
126NEK60.39108718
127TIE10.38770695
128LCK0.38719183
129TNK20.38164894
130AURKB0.36443568
131MAPK10.36227383
132FER0.35675009
133EPHA30.35626951
134CLK10.35402711
135GSK3A0.35209745
136RPS6KA20.34540424

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.48375336
2Small cell lung cancer_Homo sapiens_hsa052222.11288424
3Focal adhesion_Homo sapiens_hsa045102.09632136
4Chronic myeloid leukemia_Homo sapiens_hsa052201.94864117
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.93040064
6AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.83466230
7Proteoglycans in cancer_Homo sapiens_hsa052051.81878231
8Malaria_Homo sapiens_hsa051441.77676393
9Leishmaniasis_Homo sapiens_hsa051401.73403553
10MicroRNAs in cancer_Homo sapiens_hsa052061.68794513
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.66000651
12Adherens junction_Homo sapiens_hsa045201.65883877
13Amoebiasis_Homo sapiens_hsa051461.65842220
14Thyroid cancer_Homo sapiens_hsa052161.62896797
15Osteoclast differentiation_Homo sapiens_hsa043801.56802317
16Viral myocarditis_Homo sapiens_hsa054161.54834775
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.54660542
18Toxoplasmosis_Homo sapiens_hsa051451.54635076
19Bladder cancer_Homo sapiens_hsa052191.53072376
20Shigellosis_Homo sapiens_hsa051311.48291947
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.44311875
22Apoptosis_Homo sapiens_hsa042101.43735179
23p53 signaling pathway_Homo sapiens_hsa041151.42808756
24Pentose phosphate pathway_Homo sapiens_hsa000301.40593832
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.38180476
26TNF signaling pathway_Homo sapiens_hsa046681.36334409
27Acute myeloid leukemia_Homo sapiens_hsa052211.28886179
28Pancreatic cancer_Homo sapiens_hsa052121.28407927
29Notch signaling pathway_Homo sapiens_hsa043301.26276156
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25425869
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.25046311
32Measles_Homo sapiens_hsa051621.24736992
33B cell receptor signaling pathway_Homo sapiens_hsa046621.24135353
34HTLV-I infection_Homo sapiens_hsa051661.22263403
35Lysosome_Homo sapiens_hsa041421.20858962
36Viral carcinogenesis_Homo sapiens_hsa052031.19014614
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18520005
38Antigen processing and presentation_Homo sapiens_hsa046121.15997392
39Hepatitis B_Homo sapiens_hsa051611.15945064
40Fructose and mannose metabolism_Homo sapiens_hsa000511.14107472
41ErbB signaling pathway_Homo sapiens_hsa040121.10593370
42Salmonella infection_Homo sapiens_hsa051321.08757707
43Tuberculosis_Homo sapiens_hsa051521.08523414
44Legionellosis_Homo sapiens_hsa051341.08275928
45Insulin signaling pathway_Homo sapiens_hsa049101.08018310
46TGF-beta signaling pathway_Homo sapiens_hsa043501.05939487
47Platelet activation_Homo sapiens_hsa046111.05162501
48HIF-1 signaling pathway_Homo sapiens_hsa040661.04325413
49mTOR signaling pathway_Homo sapiens_hsa041501.04068524
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03968432
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.03811826
52Prion diseases_Homo sapiens_hsa050201.02994747
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99808386
54One carbon pool by folate_Homo sapiens_hsa006700.99042158
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98923137
56Hippo signaling pathway_Homo sapiens_hsa043900.98366485
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97940105
58AMPK signaling pathway_Homo sapiens_hsa041520.97073343
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.95583353
60Influenza A_Homo sapiens_hsa051640.95282684
61Choline metabolism in cancer_Homo sapiens_hsa052310.95176589
62Pertussis_Homo sapiens_hsa051330.94696638
63Hematopoietic cell lineage_Homo sapiens_hsa046400.94361326
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.93907245
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93524498
66Inositol phosphate metabolism_Homo sapiens_hsa005620.93143822
67GnRH signaling pathway_Homo sapiens_hsa049120.93014718
68Prostate cancer_Homo sapiens_hsa052150.92687417
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.92616292
70Dilated cardiomyopathy_Homo sapiens_hsa054140.91956432
71Lysine degradation_Homo sapiens_hsa003100.91905084
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91458712
73Herpes simplex infection_Homo sapiens_hsa051680.91108226
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91107476
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90234084
76Other glycan degradation_Homo sapiens_hsa005110.90053437
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89924758
78Estrogen signaling pathway_Homo sapiens_hsa049150.89709353
79Pathways in cancer_Homo sapiens_hsa052000.88470975
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.87873844
81Protein digestion and absorption_Homo sapiens_hsa049740.87687938
82Galactose metabolism_Homo sapiens_hsa000520.87673566
83N-Glycan biosynthesis_Homo sapiens_hsa005100.85932584
84VEGF signaling pathway_Homo sapiens_hsa043700.85468326
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84113189
86Melanoma_Homo sapiens_hsa052180.82539804
87Cell cycle_Homo sapiens_hsa041100.82435509
88Phagosome_Homo sapiens_hsa041450.81736589
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79850807
90Colorectal cancer_Homo sapiens_hsa052100.79429769
91Insulin resistance_Homo sapiens_hsa049310.79174235
92Renal cell carcinoma_Homo sapiens_hsa052110.78281953
93Non-small cell lung cancer_Homo sapiens_hsa052230.77226468
94Glioma_Homo sapiens_hsa052140.77142607
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76962425
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76529349
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.76149686
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.71946185
99Rap1 signaling pathway_Homo sapiens_hsa040150.71903974
100Hepatitis C_Homo sapiens_hsa051600.69881660
101Basal cell carcinoma_Homo sapiens_hsa052170.69753637
102Epstein-Barr virus infection_Homo sapiens_hsa051690.69593469
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.69204930
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68854552
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67791653
106Caffeine metabolism_Homo sapiens_hsa002320.67283742
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67085773
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66587939
109Biosynthesis of amino acids_Homo sapiens_hsa012300.65595911
110Prolactin signaling pathway_Homo sapiens_hsa049170.64325529
111Endometrial cancer_Homo sapiens_hsa052130.63854615
112Staphylococcus aureus infection_Homo sapiens_hsa051500.62410879
113FoxO signaling pathway_Homo sapiens_hsa040680.62380477
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61933376
115T cell receptor signaling pathway_Homo sapiens_hsa046600.61756543
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59379247
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58833539
118Chemokine signaling pathway_Homo sapiens_hsa040620.58106411
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58057409
120RNA transport_Homo sapiens_hsa030130.57050877
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56997540
122Endocytosis_Homo sapiens_hsa041440.56467248
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50599010
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45117675
125Vibrio cholerae infection_Homo sapiens_hsa051100.40767435

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