PIF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.37961936
2mitotic sister chromatid segregation (GO:0000070)5.89451765
3protein localization to chromosome, centromeric region (GO:0071459)5.81549050
4sister chromatid segregation (GO:0000819)5.56848541
5mitotic metaphase plate congression (GO:0007080)5.44269100
6kinetochore organization (GO:0051383)5.15837427
7mitotic chromosome condensation (GO:0007076)5.03837544
8regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.99947722
9DNA unwinding involved in DNA replication (GO:0006268)4.91159179
10metaphase plate congression (GO:0051310)4.84090548
11regulation of spindle organization (GO:0090224)4.77416779
12regulation of posttranscriptional gene silencing (GO:0060147)4.73832729
13regulation of gene silencing by miRNA (GO:0060964)4.73832729
14regulation of gene silencing by RNA (GO:0060966)4.73832729
15establishment of chromosome localization (GO:0051303)4.54105247
16kinetochore assembly (GO:0051382)4.53883602
17mitotic nuclear envelope disassembly (GO:0007077)4.52275591
18attachment of spindle microtubules to kinetochore (GO:0008608)4.42781117
19meiotic chromosome segregation (GO:0045132)4.33450588
20positive regulation of chromosome segregation (GO:0051984)4.30127161
21regulation of mitotic spindle organization (GO:0060236)4.24985181
22nuclear pore organization (GO:0006999)4.23432166
23nuclear envelope disassembly (GO:0051081)4.18998523
24membrane disassembly (GO:0030397)4.18998523
25CENP-A containing nucleosome assembly (GO:0034080)4.13652775
26protein localization to chromosome (GO:0034502)4.11343950
27nuclear pore complex assembly (GO:0051292)4.11199507
28chromatin remodeling at centromere (GO:0031055)4.08200485
29positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.97860722
30positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.97860722
31positive regulation of mitotic sister chromatid separation (GO:1901970)3.97860722
32DNA replication initiation (GO:0006270)3.96277882
33DNA strand elongation involved in DNA replication (GO:0006271)3.94532488
34spindle checkpoint (GO:0031577)3.89094128
35regulation of chromosome segregation (GO:0051983)3.85093860
36DNA replication-independent nucleosome organization (GO:0034724)3.80316335
37DNA replication-independent nucleosome assembly (GO:0006336)3.80316335
38DNA strand elongation (GO:0022616)3.79722574
39chromosome segregation (GO:0007059)3.78117501
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.76736637
41DNA replication-dependent nucleosome assembly (GO:0006335)3.76278365
42DNA replication-dependent nucleosome organization (GO:0034723)3.76278365
43DNA deamination (GO:0045006)3.71418282
44regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.66895164
45spindle assembly checkpoint (GO:0071173)3.66811185
46negative regulation of chromosome segregation (GO:0051985)3.65874903
47DNA replication checkpoint (GO:0000076)3.65851046
48DNA topological change (GO:0006265)3.65462792
49telomere maintenance via semi-conservative replication (GO:0032201)3.61866615
50DNA ligation (GO:0006266)3.60907061
51behavioral response to nicotine (GO:0035095)3.59105233
52negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.56917990
53negative regulation of sister chromatid segregation (GO:0033046)3.56917990
54negative regulation of mitotic sister chromatid separation (GO:2000816)3.56917990
55negative regulation of mitotic sister chromatid segregation (GO:0033048)3.56917990
56mitotic spindle assembly checkpoint (GO:0007094)3.54823406
57regulation of exit from mitosis (GO:0007096)3.53037470
58mitotic spindle checkpoint (GO:0071174)3.52902865
59maturation of 5.8S rRNA (GO:0000460)3.52323917
60histone exchange (GO:0043486)3.52047917
61regulation of mitotic metaphase/anaphase transition (GO:0030071)3.51591822
62mitotic recombination (GO:0006312)3.47797291
63regulation of histone H3-K9 methylation (GO:0051570)3.47689890
64regulation of centrosome cycle (GO:0046605)3.47090315
65folic acid-containing compound biosynthetic process (GO:0009396)3.46600592
66chromosome condensation (GO:0030261)3.46179677
67negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.45656057
68regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.43010469
69* DNA duplex unwinding (GO:0032508)3.42611537
70* DNA geometric change (GO:0032392)3.42188320
71regulation of mitotic sister chromatid separation (GO:0010965)3.41072046
72regulation of mitotic sister chromatid segregation (GO:0033047)3.41072046
73regulation of sister chromatid segregation (GO:0033045)3.41072046
74regulation of sister chromatid cohesion (GO:0007063)3.40888145
75chromatin assembly or disassembly (GO:0006333)3.39246888
76pseudouridine synthesis (GO:0001522)3.34467197
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34233535
78mitotic sister chromatid cohesion (GO:0007064)3.32596820
79telomere maintenance via recombination (GO:0000722)3.32086380
80DNA double-strand break processing (GO:0000729)3.30179187
81nuclear envelope organization (GO:0006998)3.29033184
82negative regulation of DNA-dependent DNA replication (GO:2000104)3.28196843
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.25493415
84regulation of mitotic spindle checkpoint (GO:1903504)3.25493415
85replication fork processing (GO:0031297)3.24756558
86formation of translation preinitiation complex (GO:0001731)3.24471362
87protein K6-linked ubiquitination (GO:0085020)3.24389204
88nucleobase biosynthetic process (GO:0046112)3.20195292
89DNA strand renaturation (GO:0000733)3.20141186
90pore complex assembly (GO:0046931)3.17128586
91IMP biosynthetic process (GO:0006188)3.16419051
92* DNA conformation change (GO:0071103)3.14467664
93ATP-dependent chromatin remodeling (GO:0043044)3.13656082
94maturation of SSU-rRNA (GO:0030490)3.13410791
95viral transcription (GO:0019083)3.12967361
96negative regulation of histone methylation (GO:0031061)3.12381855
97negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10440184
98translational termination (GO:0006415)3.09187224
99microtubule depolymerization (GO:0007019)3.08081268
100telomere maintenance via telomere lengthening (GO:0010833)3.06629693
101ribosomal small subunit assembly (GO:0000028)3.06080872
102regulation of centriole replication (GO:0046599)3.01749153
103regulation of mesoderm development (GO:2000380)3.01387987
104DNA packaging (GO:0006323)3.01246633
105negative regulation of translation, ncRNA-mediated (GO:0040033)3.00643398
106regulation of translation, ncRNA-mediated (GO:0045974)3.00643398
107negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00643398
108DNA catabolic process, exonucleolytic (GO:0000738)3.00421520
109negative regulation of RNA splicing (GO:0033119)2.93014816
110mitotic cell cycle (GO:0000278)2.92002204
111L-serine metabolic process (GO:0006563)2.91141457
112intra-S DNA damage checkpoint (GO:0031573)2.90207035
113heterochromatin organization (GO:0070828)2.88926712
114establishment of mitotic spindle localization (GO:0040001)2.88901487
115DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.88834809
116histone-serine phosphorylation (GO:0035404)2.87694738
117regulation of translational fidelity (GO:0006450)2.85748968
118translational initiation (GO:0006413)2.85345762
119negative regulation of mRNA processing (GO:0050686)2.84368886
120establishment of protein localization to mitochondrial membrane (GO:0090151)2.81963465
121somatic hypermutation of immunoglobulin genes (GO:0016446)2.81684398
122somatic diversification of immune receptors via somatic mutation (GO:0002566)2.81684398
123nucleotide-excision repair, DNA gap filling (GO:0006297)2.81369632
124translational elongation (GO:0006414)2.80595809
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.79419771
126negative regulation of mitosis (GO:0045839)2.77312468
127DNA damage response, detection of DNA damage (GO:0042769)2.77247066
128centriole replication (GO:0007099)2.74156203
129recombinational repair (GO:0000725)2.73338174
130synapsis (GO:0007129)2.72361866
131reciprocal DNA recombination (GO:0035825)2.70380333
132reciprocal meiotic recombination (GO:0007131)2.70380333
133rRNA catabolic process (GO:0016075)2.70197602
134spindle assembly involved in mitosis (GO:0090307)2.68402099
135regulation of mitochondrial translation (GO:0070129)2.67565483
136mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.67264142
137spliceosomal snRNP assembly (GO:0000387)2.67220714
138establishment of integrated proviral latency (GO:0075713)2.66122841
139double-strand break repair via homologous recombination (GO:0000724)2.65664854
140ncRNA catabolic process (GO:0034661)2.65371873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.22209375
2* FOXM1_23109430_ChIP-Seq_U2OS_Human7.34243392
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.51931983
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.23378557
5* MYC_18555785_ChIP-Seq_MESCs_Mouse3.68034473
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32285819
7ZNF274_21170338_ChIP-Seq_K562_Hela3.15346062
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84749618
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53804481
10AR_21909140_ChIP-Seq_LNCAP_Human2.49746713
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.48805370
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43486628
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34894832
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.26928007
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22114459
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16822952
17* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16364497
18XRN2_22483619_ChIP-Seq_HELA_Human2.15779923
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.15508750
20VDR_22108803_ChIP-Seq_LS180_Human2.09633752
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08765579
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.05538322
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03199348
24MYC_22102868_ChIP-Seq_BL_Human2.02530700
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95693451
26* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89780341
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89126581
28IRF1_19129219_ChIP-ChIP_H3396_Human1.88541141
29SOX2_16153702_ChIP-ChIP_HESCs_Human1.87789817
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79448149
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.76767731
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74938127
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.74206422
34CIITA_25753668_ChIP-Seq_RAJI_Human1.74105042
35EWS_26573619_Chip-Seq_HEK293_Human1.73046997
36VDR_23849224_ChIP-Seq_CD4+_Human1.71375633
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68668950
38FOXP3_21729870_ChIP-Seq_TREG_Human1.66153330
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62234072
40TTF2_22483619_ChIP-Seq_HELA_Human1.62164257
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59567100
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58195563
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.58114943
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56969589
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56275692
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52628777
47DCP1A_22483619_ChIP-Seq_HELA_Human1.50882354
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.46001331
49NANOG_16153702_ChIP-ChIP_HESCs_Human1.45518220
50VDR_21846776_ChIP-Seq_THP-1_Human1.44952427
51KDM5A_27292631_Chip-Seq_BREAST_Human1.44750247
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44182395
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42669648
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39774351
55GABP_19822575_ChIP-Seq_HepG2_Human1.37067581
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36987283
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35504534
58ELK1_19687146_ChIP-ChIP_HELA_Human1.35264565
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34751867
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33533922
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32561732
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30104350
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27180829
64FUS_26573619_Chip-Seq_HEK293_Human1.26896091
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26804526
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26381056
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23477902
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22852881
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21108251
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19689446
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19054141
72* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19044479
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18358808
74* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17790821
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17531813
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.16008531
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13953198
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11500095
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09720135
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09303643
81TFEB_21752829_ChIP-Seq_HELA_Human1.08483452
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08297289
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07603217
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06630864
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04435895
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04435895
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04435895
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.04042937
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.03511791
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00422047
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99946917
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99006324
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98481189
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98075409
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98066875
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97580723
97* NANOG_21062744_ChIP-ChIP_HESCs_Human0.96684473
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96474650
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96057482
100TP53_22573176_ChIP-Seq_HFKS_Human0.95672419
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95197200
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89562134
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89304753
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88732364
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.87471897
106CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87162346
107TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87047594
108MYC_18940864_ChIP-ChIP_HL60_Human0.84997838
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83401212
110CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83336376
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83173254
112E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.82873129
113SPI1_23547873_ChIP-Seq_NB4_Human0.82736488
114HOXB7_26014856_ChIP-Seq_BT474_Human0.82195801
115UTX_26944678_Chip-Seq_JUKART_Human0.80941274
116GATA1_26923725_Chip-Seq_HPCs_Mouse0.80198318
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.79469051
118FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78763490
119FOXA1_25329375_ChIP-Seq_VCAP_Human0.78763490
120HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77937750
121P300_19829295_ChIP-Seq_ESCs_Human0.77904041
122* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77791849
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76557666
124KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75896992
125* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.75067203
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74147305
127* GATA3_21878914_ChIP-Seq_MCF-7_Human0.72835469
128TCF3_18692474_ChIP-Seq_MESCs_Mouse0.72546045
129ESR1_15608294_ChIP-ChIP_MCF-7_Human0.71995324
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.71700493
131EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.71158438
132IGF1R_20145208_ChIP-Seq_DFB_Human0.71044208
133PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70802869
134ERA_21632823_ChIP-Seq_H3396_Human0.70615624
135RBPJ_22232070_ChIP-Seq_NCS_Mouse0.69312574
136SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.67507283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.61045301
2* MP0003111_abnormal_nucleus_morphology5.06347988
3MP0010094_abnormal_chromosome_stability4.68663053
4MP0004957_abnormal_blastocyst_morpholog4.28602838
5MP0003077_abnormal_cell_cycle4.27863541
6MP0008057_abnormal_DNA_replication3.80149606
7MP0002254_reproductive_system_inflammat3.03839606
8MP0008058_abnormal_DNA_repair2.76415327
9MP0003136_yellow_coat_color2.69326141
10MP0008007_abnormal_cellular_replicative2.69085728
11MP0008932_abnormal_embryonic_tissue2.52387705
12MP0001730_embryonic_growth_arrest2.41997590
13MP0010307_abnormal_tumor_latency2.37061953
14MP0000350_abnormal_cell_proliferation2.36330329
15MP0002396_abnormal_hematopoietic_system2.32763713
16MP0002938_white_spotting2.27097825
17MP0010352_gastrointestinal_tract_polyps2.10692640
18MP0003123_paternal_imprinting1.91910136
19MP0005076_abnormal_cell_differentiation1.87942322
20MP0005380_embryogenesis_phenotype1.87337996
21MP0001672_abnormal_embryogenesis/_devel1.87337996
22MP0001697_abnormal_embryo_size1.84729188
23MP0000490_abnormal_crypts_of1.77077802
24MP0002085_abnormal_embryonic_tissue1.72814508
25MP0004147_increased_porphyrin_level1.68524415
26MP0003984_embryonic_growth_retardation1.67833775
27MP0002080_prenatal_lethality1.66393945
28MP0004808_abnormal_hematopoietic_stem1.64416541
29MP0002088_abnormal_embryonic_growth/wei1.64073393
30MP0002234_abnormal_pharynx_morphology1.62622674
31MP0002086_abnormal_extraembryonic_tissu1.61027343
32MP0001529_abnormal_vocalization1.60272462
33MP0004197_abnormal_fetal_growth/weight/1.59561814
34MP0002084_abnormal_developmental_patter1.58984809
35MP0006072_abnormal_retinal_apoptosis1.58942693
36MP0003786_premature_aging1.54059707
37MP0010030_abnormal_orbit_morphology1.51004741
38MP0000313_abnormal_cell_death1.50844104
39MP0002736_abnormal_nociception_after1.47198551
40MP0008872_abnormal_physiological_respon1.45498895
41MP0002019_abnormal_tumor_incidence1.44435190
42MP0000631_abnormal_neuroendocrine_gland1.44338231
43MP0008877_abnormal_DNA_methylation1.42769027
44MP0001485_abnormal_pinna_reflex1.38392703
45MP0003705_abnormal_hypodermis_morpholog1.37669239
46MP0009697_abnormal_copulation1.35178611
47MP0003121_genomic_imprinting1.34181471
48MP0001545_abnormal_hematopoietic_system1.33990194
49MP0005397_hematopoietic_system_phenotyp1.33990194
50MP0002163_abnormal_gland_morphology1.32271285
51MP0005551_abnormal_eye_electrophysiolog1.30653128
52MP0000372_irregular_coat_pigmentation1.27842776
53MP0003646_muscle_fatigue1.26852737
54MP0005645_abnormal_hypothalamus_physiol1.26420451
55MP0000703_abnormal_thymus_morphology1.26383112
56MP0009278_abnormal_bone_marrow1.23572066
57MP0002653_abnormal_ependyma_morphology1.20658397
58MP0001293_anophthalmia1.20471698
59MP0003567_abnormal_fetal_cardiomyocyte1.20006188
60MP0003718_maternal_effect1.18434918
61MP0008789_abnormal_olfactory_epithelium1.16964028
62MP0005253_abnormal_eye_physiology1.16400895
63MP0006054_spinal_hemorrhage1.14554309
64MP0001968_abnormal_touch/_nociception1.14449765
65MP0000566_synostosis1.13592162
66MP0009053_abnormal_anal_canal1.10923155
67MP0002722_abnormal_immune_system1.10593749
68MP0002398_abnormal_bone_marrow1.09463755
69MP0009672_abnormal_birth_weight1.07267431
70MP0001873_stomach_inflammation1.06578485
71MP0002751_abnormal_autonomic_nervous1.06414451
72MP0003566_abnormal_cell_adhesion1.06222135
73MP0003787_abnormal_imprinting1.02488463
74MP0003698_abnormal_male_reproductive1.01321744
75MP0003890_abnormal_embryonic-extraembry0.99657697
76MP0000427_abnormal_hair_cycle0.99579238
77MP0005377_hearing/vestibular/ear_phenot0.98011822
78MP0003878_abnormal_ear_physiology0.98011822
79MP0000689_abnormal_spleen_morphology0.96536726
80MP0000537_abnormal_urethra_morphology0.96514039
81MP0002210_abnormal_sex_determination0.94845498
82MP0005394_taste/olfaction_phenotype0.94799952
83MP0005499_abnormal_olfactory_system0.94799952
84MP0003937_abnormal_limbs/digits/tail_de0.94079772
85MP0003011_delayed_dark_adaptation0.93710860
86MP0001915_intracranial_hemorrhage0.92049573
87MP0002111_abnormal_tail_morphology0.91599970
88MP0001919_abnormal_reproductive_system0.91490784
89MP0001849_ear_inflammation0.91330186
90MP0009333_abnormal_splenocyte_physiolog0.91011456
91MP0003195_calcinosis0.90556026
92MP0001346_abnormal_lacrimal_gland0.90191222
93MP0006035_abnormal_mitochondrial_morpho0.90123791
94MP0009703_decreased_birth_body0.89858338
95MP0002837_dystrophic_cardiac_calcinosis0.89441451
96MP0004742_abnormal_vestibular_system0.89425713
97MP0003938_abnormal_ear_development0.89261507
98MP0009046_muscle_twitch0.86973601
99MP0000858_altered_metastatic_potential0.86293971
100MP0001145_abnormal_male_reproductive0.85975395
101MP0005621_abnormal_cell_physiology0.85838624
102MP0003941_abnormal_skin_development0.85794225
103MP0003755_abnormal_palate_morphology0.84850690
104MP0002735_abnormal_chemical_nociception0.82218922
105MP0002233_abnormal_nose_morphology0.81511916
106MP0000733_abnormal_muscle_development0.80969133
107MP0004142_abnormal_muscle_tone0.79972488
108MP0000647_abnormal_sebaceous_gland0.79921793
109MP0004885_abnormal_endolymph0.79640848
110MP0001984_abnormal_olfaction0.79574671
111MP0005195_abnormal_posterior_eye0.79005516
112MP0003119_abnormal_digestive_system0.78966911
113MP0005384_cellular_phenotype0.78824936
114MP0002429_abnormal_blood_cell0.78669651
115MP0005389_reproductive_system_phenotype0.78342415
116MP0005023_abnormal_wound_healing0.77632740
117MP0008995_early_reproductive_senescence0.77408868
118MP0005391_vision/eye_phenotype0.76767643
119MP0002092_abnormal_eye_morphology0.76619816
120MP0003315_abnormal_perineum_morphology0.75764878
121MP0006292_abnormal_olfactory_placode0.74907281
122MP0001929_abnormal_gametogenesis0.73998646
123MP0003763_abnormal_thymus_physiology0.73860484
124MP0004264_abnormal_extraembryonic_tissu0.73509474
125MP0001986_abnormal_taste_sensitivity0.73450976
126MP0000428_abnormal_craniofacial_morphol0.73353068
127MP0002102_abnormal_ear_morphology0.73068838
128MP0000653_abnormal_sex_gland0.70520898
129MP0003656_abnormal_erythrocyte_physiolo0.69401835
130MP0002697_abnormal_eye_size0.68841316
131MP0000432_abnormal_head_morphology0.68310975
132MP0002925_abnormal_cardiovascular_devel0.67321649
133MP0005379_endocrine/exocrine_gland_phen0.67145109
134MP0002638_abnormal_pupillary_reflex0.67023613
135MP0003935_abnormal_craniofacial_develop0.66764492
136MP0001286_abnormal_eye_development0.66423331
137MP0008770_decreased_survivor_rate0.66228601
138MP0000477_abnormal_intestine_morphology0.65685772
139MP0000716_abnormal_immune_system0.64027240
140MP0004133_heterotaxia0.61761480
141MP0001727_abnormal_embryo_implantation0.59528490
142MP0001119_abnormal_female_reproductive0.58816282
143MP0003861_abnormal_nervous_system0.57311968
144MP0002132_abnormal_respiratory_system0.56493024
145MP0003115_abnormal_respiratory_system0.56217965
146MP0000049_abnormal_middle_ear0.55995343
147MP0000266_abnormal_heart_morphology0.54070232
148MP0005501_abnormal_skin_physiology0.53570916
149MP0003221_abnormal_cardiomyocyte_apopto0.53474107
150MP0000358_abnormal_cell_content/0.53353287
151MP0003448_altered_tumor_morphology0.53236532
152MP0002249_abnormal_larynx_morphology0.52691012
153MP0002075_abnormal_coat/hair_pigmentati0.52144938
154MP0001800_abnormal_humoral_immune0.51881458

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.70598047
2Chromsome breakage (HP:0040012)4.70081264
3Reticulocytopenia (HP:0001896)3.95108878
4Meckel diverticulum (HP:0002245)3.28837831
5Abnormality of chromosome stability (HP:0003220)3.27359986
6Ependymoma (HP:0002888)3.27115025
7Birth length less than 3rd percentile (HP:0003561)3.19657461
8Abnormality of the preputium (HP:0100587)3.16466790
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.14315185
10Abnormality of the ileum (HP:0001549)3.13832747
11Selective tooth agenesis (HP:0001592)3.12400509
12Patellar aplasia (HP:0006443)3.12170912
13Aplasia/Hypoplasia of the patella (HP:0006498)3.09541013
14Abnormality of cells of the erythroid lineage (HP:0012130)3.07751950
15Increased nuchal translucency (HP:0010880)3.04775730
16Pendular nystagmus (HP:0012043)3.04480946
17Medulloblastoma (HP:0002885)3.03872849
18Small intestinal stenosis (HP:0012848)3.03418906
19Duodenal stenosis (HP:0100867)3.03418906
20Impulsivity (HP:0100710)3.01410918
21Myelodysplasia (HP:0002863)2.96293632
22Pancreatic cysts (HP:0001737)2.94449929
23Septo-optic dysplasia (HP:0100842)2.93568578
24Carpal bone hypoplasia (HP:0001498)2.91519815
25Bilateral microphthalmos (HP:0007633)2.90454339
26Abnormal number of erythroid precursors (HP:0012131)2.87544743
27Breast hypoplasia (HP:0003187)2.84829437
28Absent radius (HP:0003974)2.73894987
29Pancreatic fibrosis (HP:0100732)2.71754116
30Absent thumb (HP:0009777)2.63348578
31Hypoplasia of the pons (HP:0012110)2.62231991
32Proximal placement of thumb (HP:0009623)2.62078192
33Deviation of the thumb (HP:0009603)2.58159426
34Abnormality of the labia minora (HP:0012880)2.57759091
35Molar tooth sign on MRI (HP:0002419)2.55757749
36Abnormality of midbrain morphology (HP:0002418)2.55757749
37Degeneration of anterior horn cells (HP:0002398)2.55042615
38Abnormality of the anterior horn cell (HP:0006802)2.55042615
39Ectopic kidney (HP:0000086)2.54870140
40Volvulus (HP:0002580)2.53551954
41Absent forearm bone (HP:0003953)2.53424480
42Aplasia involving forearm bones (HP:0009822)2.53424480
43Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.52937497
44Short 4th metacarpal (HP:0010044)2.52937497
45Basal cell carcinoma (HP:0002671)2.52713080
46Abnormality of the pons (HP:0007361)2.52541144
47Rhabdomyosarcoma (HP:0002859)2.52538001
48Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.51098738
49Duplicated collecting system (HP:0000081)2.50691865
50Abnormality of the duodenum (HP:0002246)2.48139464
51True hermaphroditism (HP:0010459)2.47623070
52Abnormal number of incisors (HP:0011064)2.47237795
53Nephroblastoma (Wilms tumor) (HP:0002667)2.45935205
54Colon cancer (HP:0003003)2.44772903
55Sloping forehead (HP:0000340)2.44166610
56Cafe-au-lait spot (HP:0000957)2.42529239
57Oral leukoplakia (HP:0002745)2.40366027
58Congenital stationary night blindness (HP:0007642)2.39463011
59Abnormal lung lobation (HP:0002101)2.38210807
60Abnormality of the carotid arteries (HP:0005344)2.37839981
61Nephronophthisis (HP:0000090)2.37375192
62Abnormality of reticulocytes (HP:0004312)2.35093455
63Type II lissencephaly (HP:0007260)2.33932742
64Squamous cell carcinoma (HP:0002860)2.31120101
6511 pairs of ribs (HP:0000878)2.31010740
66Bone marrow hypocellularity (HP:0005528)2.30969725
67Pallor (HP:0000980)2.30856491
68Cerebellar dysplasia (HP:0007033)2.30140964
69Facial hemangioma (HP:0000329)2.27684016
70Tracheoesophageal fistula (HP:0002575)2.24782101
71Embryonal renal neoplasm (HP:0011794)2.24667229
72Abnormality of the astrocytes (HP:0100707)2.22846928
73Astrocytoma (HP:0009592)2.22846928
74Partial agenesis of the corpus callosum (HP:0001338)2.21664751
75Agnosia (HP:0010524)2.17011850
76Lissencephaly (HP:0001339)2.16601560
77Short thumb (HP:0009778)2.16572864
78High pitched voice (HP:0001620)2.16256631
79Acute necrotizing encephalopathy (HP:0006965)2.15780167
80Optic nerve hypoplasia (HP:0000609)2.15128840
81Neoplasm of the pancreas (HP:0002894)2.14469181
82Missing ribs (HP:0000921)2.14358123
83Rib fusion (HP:0000902)2.10187408
84Atresia of the external auditory canal (HP:0000413)2.09981819
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08759054
86Macrocytic anemia (HP:0001972)2.07855343
87Abnormality of DNA repair (HP:0003254)2.07366278
88Abnormality of the renal collecting system (HP:0004742)2.07154424
89Neoplasm of striated muscle (HP:0009728)2.05389277
90Sclerocornea (HP:0000647)2.04486629
91Prominent nose (HP:0000448)2.03622165
92Dandy-Walker malformation (HP:0001305)2.03395729
93Acute encephalopathy (HP:0006846)2.00611163
94Neoplasm of the oral cavity (HP:0100649)2.00119680
95Anencephaly (HP:0002323)1.98112374
96Neoplasm of the adrenal cortex (HP:0100641)1.95672006
97Abnormality of chromosome segregation (HP:0002916)1.95018638
98Absent septum pellucidum (HP:0001331)1.94953221
99Triphalangeal thumb (HP:0001199)1.94428287
100Glioma (HP:0009733)1.93785510
101Abnormality of the renal medulla (HP:0100957)1.93200154
102Rough bone trabeculation (HP:0100670)1.93113413
103Horseshoe kidney (HP:0000085)1.93033962
104Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92972956
105Clubbing of toes (HP:0100760)1.92640611
106Cortical dysplasia (HP:0002539)1.92382526
107Abnormality of the fingertips (HP:0001211)1.92351364
108Hyperglycinuria (HP:0003108)1.89890000
109Long eyelashes (HP:0000527)1.89760765
110Increased CSF lactate (HP:0002490)1.88730084
111Premature graying of hair (HP:0002216)1.88678665
112Overlapping toe (HP:0001845)1.84055996
113Cystic liver disease (HP:0006706)1.83772037
114Mitochondrial inheritance (HP:0001427)1.83259876
115Abnormal mitochondria in muscle tissue (HP:0008316)1.82637839
116Aplasia/Hypoplasia of the sternum (HP:0006714)1.81061877
117Amaurosis fugax (HP:0100576)1.78354543
118Broad palm (HP:0001169)1.77129967
119Aplasia/hypoplasia of the humerus (HP:0006507)1.76744135
120Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76204200
121Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76204200
122Abnormality of the calcaneus (HP:0008364)1.75326574
123Retinal dysplasia (HP:0007973)1.73950431
124Small hand (HP:0200055)1.73151237
125Aplasia/Hypoplasia of the spleen (HP:0010451)1.72238662
126Attenuation of retinal blood vessels (HP:0007843)1.72057090
127Abnormality of abdominal situs (HP:0011620)1.71731792
128Abdominal situs inversus (HP:0003363)1.71731792
129Cutaneous melanoma (HP:0012056)1.71727791
130Pseudobulbar signs (HP:0002200)1.71182261
131Abnormality of the heme biosynthetic pathway (HP:0010472)1.70913497
132Renal duplication (HP:0000075)1.70766461
133Lipid accumulation in hepatocytes (HP:0006561)1.70217196
134Thrombocytosis (HP:0001894)1.70180793
135Holoprosencephaly (HP:0001360)1.70059896
136Supernumerary spleens (HP:0009799)1.69924188
137Preaxial hand polydactyly (HP:0001177)1.69185603
138Abnormality of the 4th metacarpal (HP:0010012)1.67244522
139Abnormality of the septum pellucidum (HP:0007375)1.67189063
140Esophageal atresia (HP:0002032)1.67119056
141Poikiloderma (HP:0001029)1.67036059
142Cellular immunodeficiency (HP:0005374)1.66974845
143Anophthalmia (HP:0000528)1.66450725
144Hyperglycinemia (HP:0002154)1.66407444
145Increased serum lactate (HP:0002151)1.65338140
146Abolished electroretinogram (ERG) (HP:0000550)1.64985232
147Tubular atrophy (HP:0000092)1.63885030
148Congenital, generalized hypertrichosis (HP:0004540)1.63727150
149Progressive macrocephaly (HP:0004481)1.63157093
150Abnormality of serine family amino acid metabolism (HP:0010894)1.62541751
151Abnormality of glycine metabolism (HP:0010895)1.62541751
152Increased hepatocellular lipid droplets (HP:0006565)1.62117342
153Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.61996061
154Fibular aplasia (HP:0002990)1.61387615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.24198605
2CDC74.17293451
3WEE14.06717606
4NEK23.74170187
5TTK2.92873392
6VRK22.85405232
7TAF12.65406052
8BRSK22.56316558
9EEF2K2.55939381
10CDK122.55189116
11STK102.36124624
12PLK12.22253050
13MAP3K102.22199979
14SRPK12.12065950
15NEK12.10134706
16NUAK12.00377921
17BRSK11.99671878
18AURKB1.98187576
19EIF2AK11.84548773
20MAP3K81.82203876
21RPS6KB21.80339364
22BMPR1B1.77357695
23TLK11.77222359
24FRK1.72501316
25STK41.69080233
26PBK1.66893185
27CHEK21.66815684
28CDK41.63091549
29WNK31.62675524
30CDK191.60572062
31PLK31.59913462
32CDK71.59260412
33AURKA1.58798120
34ATR1.57112810
35TESK21.55833603
36MKNK11.55487527
37RPS6KA41.40362700
38PLK41.38514340
39VRK11.37567210
40NME11.37033156
41ADRBK21.36837828
42CHEK11.36714726
43PKN21.35711079
44TSSK61.30068592
45MAP4K21.26191594
46WNK41.23993956
47EPHA21.21802902
48PASK1.21025611
49DYRK31.18661453
50MKNK21.18579500
51CDK61.14781302
52DYRK21.13257372
53TNIK1.13184950
54GRK11.12519565
55NME21.07024225
56OXSR11.05944172
57ATM1.00694093
58ACVR1B0.99261610
59PAK40.96512963
60CCNB10.95324509
61ZAK0.95201359
62STK30.94803298
63CAMK1D0.93730246
64CDK20.93124079
65MELK0.90511062
66LRRK20.89980153
67BRD40.86497995
68INSRR0.86324052
69SCYL20.85638597
70PIM10.85538764
71EIF2AK20.84592991
72ALK0.83610039
73EIF2AK30.81455001
74CDK10.79986528
75MAP4K10.77681138
76CLK10.75655191
77PAK10.71665859
78STK38L0.70592457
79FLT30.66433308
80TRIB30.65776386
81MTOR0.65072214
82PRKCG0.64968747
83TGFBR10.64166664
84MAP3K40.63662904
85CAMK1G0.63568302
86PIK3CA0.62635902
87TRIM280.60602823
88GRK60.58061989
89STK160.57847356
90DAPK20.57807636
91MARK30.56548989
92FGFR20.55146819
93BCKDK0.54387802
94CSNK2A20.52677013
95CSNK1G10.51954977
96MUSK0.51813287
97MST40.49214083
98CSNK2A10.47752560
99PRKCI0.47448304
100AKT20.46871997
101MAPKAPK50.46088236
102SMG10.45698707
103CASK0.44172838
104RPS6KA50.43151500
105MAPKAPK30.43046033
106TTN0.42476994
107BTK0.41814299
108PINK10.40588455
109MAP2K30.40094040
110PRKDC0.39471216
111CDK30.39246860
112TIE10.38632485
113MAPK140.37276750
114PAK20.36623526
115MAPK130.36492468
116KDR0.36174864
117MAPKAPK20.35701969
118MAPK110.33308726
119SIK20.33150585
120CSNK1D0.33042657
121LATS10.32482555
122LATS20.32241002
123FGFR10.31466512
124ILK0.31355760
125BRAF0.30409568
126UHMK10.30256441
127BLK0.30187014
128CSNK1E0.30066469
129CSNK1G30.29050126
130AKT10.28886012
131ADRBK10.28463603
132MAP3K110.28327281
133CDK80.28204740
134MAPK10.27371119
135PKN10.27329730
136CSNK1G20.25317136
137RPS6KA10.24628496
138PNCK0.24556166
139STK110.24259757
140CSNK1A10.23870789
141RPS6KC10.22678762
142RPS6KL10.22678762
143PTK60.21576325
144GSK3B0.21369478
145TRPM70.21076913
146TESK10.19727984

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.55472489
2Mismatch repair_Homo sapiens_hsa034303.92043805
3Cell cycle_Homo sapiens_hsa041103.46935320
4Spliceosome_Homo sapiens_hsa030403.32145147
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17659250
6RNA transport_Homo sapiens_hsa030133.12609382
7Base excision repair_Homo sapiens_hsa034103.08125846
8Homologous recombination_Homo sapiens_hsa034403.08041016
9Ribosome_Homo sapiens_hsa030102.82338991
10One carbon pool by folate_Homo sapiens_hsa006702.80598768
11Fanconi anemia pathway_Homo sapiens_hsa034602.62916373
12Nucleotide excision repair_Homo sapiens_hsa034202.60297100
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.48606186
14Non-homologous end-joining_Homo sapiens_hsa034502.36240614
15RNA polymerase_Homo sapiens_hsa030202.33711600
16mRNA surveillance pathway_Homo sapiens_hsa030152.08569704
17p53 signaling pathway_Homo sapiens_hsa041151.96372914
18Oxidative phosphorylation_Homo sapiens_hsa001901.94602911
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90284650
20RNA degradation_Homo sapiens_hsa030181.87435095
21Pyrimidine metabolism_Homo sapiens_hsa002401.81620908
22Systemic lupus erythematosus_Homo sapiens_hsa053221.81479705
23Proteasome_Homo sapiens_hsa030501.79619368
24Parkinsons disease_Homo sapiens_hsa050121.74653902
25Basal transcription factors_Homo sapiens_hsa030221.61919220
26Phototransduction_Homo sapiens_hsa047441.52010365
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.51192295
28Protein export_Homo sapiens_hsa030601.47117836
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44476773
30Oocyte meiosis_Homo sapiens_hsa041141.44126447
31Huntingtons disease_Homo sapiens_hsa050161.41130703
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37860462
33Viral carcinogenesis_Homo sapiens_hsa052031.36741519
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32531365
35Sulfur relay system_Homo sapiens_hsa041221.30177215
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30017025
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27781494
38Linoleic acid metabolism_Homo sapiens_hsa005911.23188579
39Epstein-Barr virus infection_Homo sapiens_hsa051691.20242944
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20200715
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18277403
42Nitrogen metabolism_Homo sapiens_hsa009101.16823831
43MicroRNAs in cancer_Homo sapiens_hsa052061.14444755
44Herpes simplex infection_Homo sapiens_hsa051681.11994447
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09242301
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09170195
47HTLV-I infection_Homo sapiens_hsa051661.05797823
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05455682
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03088873
50Small cell lung cancer_Homo sapiens_hsa052221.02157218
51Steroid biosynthesis_Homo sapiens_hsa001000.95258212
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.93241712
53Alzheimers disease_Homo sapiens_hsa050100.92881027
54Antigen processing and presentation_Homo sapiens_hsa046120.89791793
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88386757
56Primary immunodeficiency_Homo sapiens_hsa053400.87618700
57Ether lipid metabolism_Homo sapiens_hsa005650.86651880
58Pentose phosphate pathway_Homo sapiens_hsa000300.86193388
59Butanoate metabolism_Homo sapiens_hsa006500.84396600
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84175007
61Propanoate metabolism_Homo sapiens_hsa006400.84050610
62Chronic myeloid leukemia_Homo sapiens_hsa052200.82962370
63Cardiac muscle contraction_Homo sapiens_hsa042600.82560385
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82092946
65Purine metabolism_Homo sapiens_hsa002300.80653887
66Caffeine metabolism_Homo sapiens_hsa002320.78904434
67Alcoholism_Homo sapiens_hsa050340.75326641
68Pyruvate metabolism_Homo sapiens_hsa006200.73891735
69Colorectal cancer_Homo sapiens_hsa052100.72512267
70Apoptosis_Homo sapiens_hsa042100.72433106
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72314102
72Biosynthesis of amino acids_Homo sapiens_hsa012300.71883667
73Tryptophan metabolism_Homo sapiens_hsa003800.71727813
74Folate biosynthesis_Homo sapiens_hsa007900.70002357
75Notch signaling pathway_Homo sapiens_hsa043300.68972003
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67497902
77Nicotine addiction_Homo sapiens_hsa050330.64979882
78Hippo signaling pathway_Homo sapiens_hsa043900.64232683
79Selenocompound metabolism_Homo sapiens_hsa004500.63677422
80Thyroid cancer_Homo sapiens_hsa052160.63569632
81Metabolic pathways_Homo sapiens_hsa011000.61702840
82Basal cell carcinoma_Homo sapiens_hsa052170.61629147
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.61113011
84Hepatitis B_Homo sapiens_hsa051610.59733589
85Vitamin B6 metabolism_Homo sapiens_hsa007500.58393035
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57994048
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56477777
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54868187
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54676182
90TGF-beta signaling pathway_Homo sapiens_hsa043500.54244285
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53870400
92Lysine degradation_Homo sapiens_hsa003100.53221884
93Bladder cancer_Homo sapiens_hsa052190.52518979
94Non-small cell lung cancer_Homo sapiens_hsa052230.52180189
95Vitamin digestion and absorption_Homo sapiens_hsa049770.50688149
96Measles_Homo sapiens_hsa051620.49994786
97Taste transduction_Homo sapiens_hsa047420.48421013
98mTOR signaling pathway_Homo sapiens_hsa041500.48317887
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.48224553
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.47785359
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47462807
102Pancreatic cancer_Homo sapiens_hsa052120.47170762
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.46195634
104B cell receptor signaling pathway_Homo sapiens_hsa046620.43008261
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42454697
106Pathways in cancer_Homo sapiens_hsa052000.42382920
107Legionellosis_Homo sapiens_hsa051340.41703269
108Acute myeloid leukemia_Homo sapiens_hsa052210.40890417
109Fat digestion and absorption_Homo sapiens_hsa049750.40715624
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39818291
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38901629
112Adherens junction_Homo sapiens_hsa045200.38871772
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37889236
114Prostate cancer_Homo sapiens_hsa052150.36630650
115Hematopoietic cell lineage_Homo sapiens_hsa046400.36409453
116Peroxisome_Homo sapiens_hsa041460.36402294
117Shigellosis_Homo sapiens_hsa051310.36273118
118HIF-1 signaling pathway_Homo sapiens_hsa040660.36131801
119Viral myocarditis_Homo sapiens_hsa054160.35249914
120Olfactory transduction_Homo sapiens_hsa047400.34954766
121FoxO signaling pathway_Homo sapiens_hsa040680.34307090
122Asthma_Homo sapiens_hsa053100.33950630
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33880379
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.33610571
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.33132085
126Influenza A_Homo sapiens_hsa051640.32016931
127Proteoglycans in cancer_Homo sapiens_hsa052050.31164333
128Hedgehog signaling pathway_Homo sapiens_hsa043400.30915384
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30767498
130Retinol metabolism_Homo sapiens_hsa008300.29218459
131Carbon metabolism_Homo sapiens_hsa012000.27908418
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27011399
133Endometrial cancer_Homo sapiens_hsa052130.26789302
134Arachidonic acid metabolism_Homo sapiens_hsa005900.26113543
135Arginine and proline metabolism_Homo sapiens_hsa003300.26078613
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25731664
137Melanoma_Homo sapiens_hsa052180.23619788
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22429043
139Glutathione metabolism_Homo sapiens_hsa004800.21970389
140Intestinal immune network for IgA production_Homo sapiens_hsa046720.21914508
141N-Glycan biosynthesis_Homo sapiens_hsa005100.21754074
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21753164
143Leishmaniasis_Homo sapiens_hsa051400.21734496
144Wnt signaling pathway_Homo sapiens_hsa043100.21272585
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21168706
146Fatty acid elongation_Homo sapiens_hsa000620.19670272
147Fructose and mannose metabolism_Homo sapiens_hsa000510.17980096
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17862583
149PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16972798
150Glycerolipid metabolism_Homo sapiens_hsa005610.16155643
151beta-Alanine metabolism_Homo sapiens_hsa004100.13484024
152Sulfur metabolism_Homo sapiens_hsa009200.13118986

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