PIGA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.43082561
2myelination (GO:0042552)6.76919965
3axon ensheathment (GO:0008366)6.76118848
4ensheathment of neurons (GO:0007272)6.76118848
5long-chain fatty acid biosynthetic process (GO:0042759)6.33826960
6cholesterol biosynthetic process (GO:0006695)5.12031578
7myelin maintenance (GO:0043217)4.85137825
8negative regulation of neurotransmitter secretion (GO:0046929)4.66423691
9sterol biosynthetic process (GO:0016126)4.48751584
10positive regulation of oligodendrocyte differentiation (GO:0048714)4.44698563
11glycerophospholipid catabolic process (GO:0046475)4.28114215
12negative regulation of neurotransmitter transport (GO:0051589)4.23735686
13protein K11-linked deubiquitination (GO:0035871)4.22753735
14microtubule polymerization or depolymerization (GO:0031109)4.17310365
15* GPI anchor biosynthetic process (GO:0006506)4.08417343
16oligodendrocyte differentiation (GO:0048709)4.07606578
17nucleotide transmembrane transport (GO:1901679)4.07594009
18isoprenoid biosynthetic process (GO:0008299)4.03178243
19amyloid precursor protein metabolic process (GO:0042982)4.02148179
20astrocyte development (GO:0014002)3.98628192
21maturation of 5.8S rRNA (GO:0000460)3.91613510
22regulation of collateral sprouting (GO:0048670)3.88122783
23* GPI anchor metabolic process (GO:0006505)3.86799090
24establishment of mitochondrion localization (GO:0051654)3.86750046
25photoreceptor cell differentiation (GO:0046530)3.84118801
26eye photoreceptor cell differentiation (GO:0001754)3.84118801
27asymmetric protein localization (GO:0008105)3.83118636
28long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.81978137
29apical protein localization (GO:0045176)3.80972420
30long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.73003570
31ribosome assembly (GO:0042255)3.61805671
32response to lipoprotein particle (GO:0055094)3.61209151
33creatine metabolic process (GO:0006600)3.60351705
34negative regulation of protein localization to cell surface (GO:2000009)3.59462599
35L-amino acid import (GO:0043092)3.54124197
36magnesium ion transport (GO:0015693)3.51649817
37import into cell (GO:0098657)3.48706402
38regulation of centriole replication (GO:0046599)3.42180729
39mannosylation (GO:0097502)3.39453653
40regulation of glucokinase activity (GO:0033131)3.34814585
41regulation of hexokinase activity (GO:1903299)3.34814585
42leukocyte migration involved in inflammatory response (GO:0002523)3.32452502
43regulation of lipoprotein metabolic process (GO:0050746)3.30005096
44monoubiquitinated protein deubiquitination (GO:0035520)3.29555439
45nuclear pore organization (GO:0006999)3.27876488
46fatty-acyl-CoA biosynthetic process (GO:0046949)3.24649936
47neural tube formation (GO:0001841)3.24136317
48L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.22778873
49interferon-gamma production (GO:0032609)3.22504185
50RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.21954254
51response to redox state (GO:0051775)3.21344846
52response to methylmercury (GO:0051597)3.19169809
53centriole replication (GO:0007099)3.14489627
54* preassembly of GPI anchor in ER membrane (GO:0016254)3.14206296
55protein palmitoylation (GO:0018345)3.14160015
56cerebral cortex radially oriented cell migration (GO:0021799)3.13924074
57nuclear pore complex assembly (GO:0051292)3.13484031
58protein neddylation (GO:0045116)3.11392160
59negative regulation of DNA-dependent DNA replication (GO:2000104)3.09991519
60positive regulation of cell fate commitment (GO:0010455)3.09671009
61positive regulation of mRNA catabolic process (GO:0061014)3.05960424
62positive regulation of glial cell differentiation (GO:0045687)3.05928653
63substantia nigra development (GO:0021762)3.05876209
64interleukin-6-mediated signaling pathway (GO:0070102)3.04094315
65presynaptic membrane organization (GO:0097090)3.03683794
66negative regulation of chemokine production (GO:0032682)3.03218391
67positive regulation of mRNA metabolic process (GO:1903313)3.02909247
68fatty-acyl-CoA metabolic process (GO:0035337)3.02296888
69pseudouridine synthesis (GO:0001522)2.98737496
70lactate metabolic process (GO:0006089)2.97274660
71negative regulation of execution phase of apoptosis (GO:1900118)2.96511498
72positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.93965657
73mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.93965657
74L-fucose catabolic process (GO:0042355)2.91554789
75fucose catabolic process (GO:0019317)2.91554789
76L-fucose metabolic process (GO:0042354)2.91554789
77positive regulation of cell cycle checkpoint (GO:1901978)2.90665717
78protein K6-linked ubiquitination (GO:0085020)2.90275274
79protein prenylation (GO:0018342)2.89778960
80prenylation (GO:0097354)2.89778960
81signal peptide processing (GO:0006465)2.89543335
82iron ion import (GO:0097286)2.88174962
83regulation of exit from mitosis (GO:0007096)2.87229556
84nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.86047667
85hepatocyte apoptotic process (GO:0097284)2.84962972
86histone H2B ubiquitination (GO:0033523)2.83775968
87glycosylceramide metabolic process (GO:0006677)2.83614860
88positive regulation of mRNA 3-end processing (GO:0031442)2.82082273
89glial cell development (GO:0021782)2.81589743
90replication fork processing (GO:0031297)2.81561925
91positive regulation of cellular amine metabolic process (GO:0033240)2.81527896
92regulation of DNA endoreduplication (GO:0032875)2.80308119
93positive regulation of mRNA processing (GO:0050685)2.79644252
94positive regulation of gliogenesis (GO:0014015)2.77661619
95mitotic nuclear envelope reassembly (GO:0007084)2.76844887
96nuclear envelope reassembly (GO:0031468)2.76844887
97protein K63-linked deubiquitination (GO:0070536)2.75515197
98ear development (GO:0043583)2.75472475
99establishment of mitotic spindle orientation (GO:0000132)2.74908331
100peripheral nervous system axon ensheathment (GO:0032292)2.72874637
101myelination in peripheral nervous system (GO:0022011)2.72874637
102negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.72759182
103ER overload response (GO:0006983)2.72515851
104centriole assembly (GO:0098534)2.71636671
105mitotic sister chromatid cohesion (GO:0007064)2.69684102
106sphingosine metabolic process (GO:0006670)2.68913346
107proteasome assembly (GO:0043248)2.68140269
108centrosome duplication (GO:0051298)2.67307267
109rRNA catabolic process (GO:0016075)2.67168486
110synapsis (GO:0007129)2.66968582
111estrogen biosynthetic process (GO:0006703)2.66223292
112L-serine metabolic process (GO:0006563)2.66108719
113organelle disassembly (GO:1903008)2.63979633
114regulation of mRNA 3-end processing (GO:0031440)2.63080210
115adhesion of symbiont to host cell (GO:0044650)2.62994554
116virion attachment to host cell (GO:0019062)2.62994554
117somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.62873673
118somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.62873673
119isotype switching (GO:0045190)2.62873673
120nucleotide transport (GO:0006862)2.62586243
121positive regulation of actin filament depolymerization (GO:0030836)2.62339785
122response to lead ion (GO:0010288)2.61673928
123peptidyl-cysteine modification (GO:0018198)2.61525876
124establishment of mitotic spindle localization (GO:0040001)2.60972634
125histone-serine phosphorylation (GO:0035404)2.60727938
126positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.60539951
127regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.60539951
128regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.60382151
129regulation of oxidative stress-induced neuron death (GO:1903203)2.59813924
130regulation of spindle checkpoint (GO:0090231)2.59497459
131regulation of cytokine production involved in inflammatory response (GO:1900015)2.58596845
132positive regulation of T-helper 1 type immune response (GO:0002827)2.58005262
133positive regulation of pseudopodium assembly (GO:0031274)2.57708197
134regulation of mRNA catabolic process (GO:0061013)2.57542001
135I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.57467383
136Golgi to endosome transport (GO:0006895)2.56821254
137amyloid precursor protein catabolic process (GO:0042987)2.56588761
138presynaptic membrane assembly (GO:0097105)2.56269780
139negative regulation of translation, ncRNA-mediated (GO:0040033)2.55621073
140regulation of translation, ncRNA-mediated (GO:0045974)2.55621073
141negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.55621073
142regulation of translation in response to stress (GO:0043555)2.55399750
143microtubule depolymerization (GO:0007019)2.54766148
144membrane tubulation (GO:0097320)2.53089379
145sphingoid metabolic process (GO:0046519)2.52964984
146DNA ligation (GO:0006266)2.52947032
147DNA replication checkpoint (GO:0000076)2.52907428
148regulation of centrosome duplication (GO:0010824)2.52678470
149regulation of somitogenesis (GO:0014807)2.52205390
150* glycolipid biosynthetic process (GO:0009247)2.52188700
151phosphatidylserine acyl-chain remodeling (GO:0036150)2.51733386
152organ growth (GO:0035265)2.51383266
153regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.50579231
154regulation of mitotic spindle checkpoint (GO:1903504)2.50579231
155N-terminal protein amino acid acetylation (GO:0006474)2.49991090
156negative regulation of JUN kinase activity (GO:0043508)2.46492471
157regulation of memory T cell differentiation (GO:0043380)2.46205046
158keratinocyte development (GO:0003334)2.45895717
159regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.44858816
160positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.43565131
161transcription elongation from RNA polymerase I promoter (GO:0006362)2.43513761
162regulation of centrosome cycle (GO:0046605)2.42580658
163negative regulation of acute inflammatory response (GO:0002674)2.38700288
164RNA destabilization (GO:0050779)2.36892099
165positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.36484234
166regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.36484234
167pyrimidine-containing compound transmembrane transport (GO:0072531)2.36017468
168meiotic chromosome segregation (GO:0045132)2.35656130
169histone mRNA metabolic process (GO:0008334)2.31762075
170single strand break repair (GO:0000012)2.31658347
171alpha-beta T cell differentiation involved in immune response (GO:0002293)2.31124656
172alpha-beta T cell activation involved in immune response (GO:0002287)2.31124656
173T cell differentiation involved in immune response (GO:0002292)2.31124656
174pore complex assembly (GO:0046931)2.31088979
175resolution of meiotic recombination intermediates (GO:0000712)2.31014730
176negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.30881776
177gene silencing by RNA (GO:0031047)2.29358607
178maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.29276673
179DNA catabolic process, exonucleolytic (GO:0000738)2.29182735
180CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.28147828
181T-helper cell differentiation (GO:0042093)2.28147828
182hair cycle (GO:0042633)2.27096127
183molting cycle (GO:0042303)2.27096127
184mitotic cell cycle arrest (GO:0071850)2.24881695
185response to pheromone (GO:0019236)2.24855059
186CENP-A containing nucleosome assembly (GO:0034080)2.23729525
187mitotic nuclear envelope disassembly (GO:0007077)2.23637842
188negative regulation of interleukin-1 beta production (GO:0032691)2.22555036
189termination of RNA polymerase I transcription (GO:0006363)2.22183071
190cytokine production involved in immune response (GO:0002367)2.19967259
191negative regulation of complement activation (GO:0045916)2.19625313
192chromatin remodeling at centromere (GO:0031055)2.18912689
193cytoplasmic mRNA processing body assembly (GO:0033962)2.17846250
194positive regulation of organelle assembly (GO:1902117)2.17834115
195central nervous system myelination (GO:0022010)12.1129776
196axon ensheathment in central nervous system (GO:0032291)12.1129776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.59205861
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.10048222
3NOTCH1_21737748_ChIP-Seq_TLL_Human2.85268793
4E2F7_22180533_ChIP-Seq_HELA_Human2.80138036
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.77058864
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.76895172
7CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.69992453
8IRF1_19129219_ChIP-ChIP_H3396_Human2.65051338
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.62392969
10TAF15_26573619_Chip-Seq_HEK293_Human2.57004030
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56554550
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53189910
13SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.44240784
14GBX2_23144817_ChIP-Seq_PC3_Human2.41875377
15FUS_26573619_Chip-Seq_HEK293_Human2.35105750
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.33946793
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.33946793
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.33946793
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27656570
20PADI4_21655091_ChIP-ChIP_MCF-7_Human2.21793417
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08200708
22ZNF274_21170338_ChIP-Seq_K562_Hela2.06135319
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05366098
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01369036
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00674645
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94700619
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90361397
28GATA1_22025678_ChIP-Seq_K562_Human1.86432002
29LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85149365
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84565391
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82505250
32VDR_22108803_ChIP-Seq_LS180_Human1.82393579
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.81852632
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80237427
35EWS_26573619_Chip-Seq_HEK293_Human1.76630853
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75214639
37ER_23166858_ChIP-Seq_MCF-7_Human1.75120651
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75043689
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74442710
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72119953
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.65843678
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.65784720
43FOXP3_21729870_ChIP-Seq_TREG_Human1.64670911
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63459314
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.61771504
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61049166
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60079604
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.59270856
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55691808
50STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.55532191
51SUZ12_18555785_Chip-Seq_ESCs_Mouse1.54574243
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52198253
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.51174309
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50635586
55P300_18555785_Chip-Seq_ESCs_Mouse1.45826104
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45020300
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44185855
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44128235
59CMYC_18555785_Chip-Seq_ESCs_Mouse1.43669962
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43048840
61AR_21909140_ChIP-Seq_LNCAP_Human1.41995974
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.41646361
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41335193
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38447008
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.38391717
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37111918
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32191590
68MYC_18940864_ChIP-ChIP_HL60_Human1.30966796
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30775088
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.30218041
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30187286
72SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.29343917
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.29026175
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.28721507
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.28288834
76KLF4_18555785_Chip-Seq_ESCs_Mouse1.26960633
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25679862
78RUNX1_27457419_Chip-Seq_LIVER_Mouse1.25269697
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25153045
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.25043030
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24979088
82ELF5_23300383_ChIP-Seq_T47D_Human1.23928550
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22144791
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21824386
85FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21363361
86SOX17_20123909_ChIP-Seq_XEN_Mouse1.21221425
87MYB_26560356_Chip-Seq_TH2_Human1.20616688
88EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.20414452
89OCT4_18555785_Chip-Seq_ESCs_Mouse1.20151100
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19380360
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18845475
92GATA1_26923725_Chip-Seq_HPCs_Mouse1.18427616
93ELK1_19687146_ChIP-ChIP_HELA_Human1.15811444
94SMAD1_18555785_Chip-Seq_ESCs_Mouse1.15660338
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.15448226
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14209986
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13673540
98HTT_18923047_ChIP-ChIP_STHdh_Human1.13264386
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.12573290
100P300_19829295_ChIP-Seq_ESCs_Human1.11492609
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11375524
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.11016159
103P53_22387025_ChIP-Seq_ESCs_Mouse1.10990658
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10962088
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09972000
106GATA3_26560356_Chip-Seq_TH2_Human1.08849998
107DCP1A_22483619_ChIP-Seq_HELA_Human1.08242777
108ELK1_22589737_ChIP-Seq_MCF10A_Human1.07659438
109* SALL4_22934838_ChIP-ChIP_CD34+_Human1.07337906
110NMYC_18555785_Chip-Seq_ESCs_Mouse1.07286693
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06905717
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06646010
113MYC_18555785_ChIP-Seq_MESCs_Mouse1.06318254
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05358923
115JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04617690
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.03654957
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03128465
118GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03027120
119HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02980675
120YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02539731
121SMAD_19615063_ChIP-ChIP_OVARY_Human1.00506421
122FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00294153
123RNF2_27304074_Chip-Seq_NSC_Mouse1.00233115
124TP63_19390658_ChIP-ChIP_HaCaT_Human1.00064764
125FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99625135
126ZFX_18555785_Chip-Seq_ESCs_Mouse0.99055315
127TTF2_22483619_ChIP-Seq_HELA_Human0.98762314
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98555988
129SOX2_19829295_ChIP-Seq_ESCs_Human0.98467262
130NANOG_19829295_ChIP-Seq_ESCs_Human0.98467262
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97130899
132KDM5A_27292631_Chip-Seq_BREAST_Human0.96714765
133E2F1_21310950_ChIP-Seq_MCF-7_Human0.96253880
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96251593
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95648168
136SCL_19346495_ChIP-Seq_HPC-7_Human0.95241061
137EOMES_21245162_ChIP-Seq_HESCs_Human0.94733874
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94572378
139CDX2_22108803_ChIP-Seq_LS180_Human0.94422203
140EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94279019
141CRX_20693478_ChIP-Seq_RETINA_Mouse0.93326883
142UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92051530
143CBX2_27304074_Chip-Seq_ESCs_Mouse0.91854656
144IRF8_21731497_ChIP-ChIP_J774_Mouse0.91606845
145FOXM1_23109430_ChIP-Seq_U2OS_Human0.91481115
146CBP_20019798_ChIP-Seq_JUKART_Human0.91383816
147IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91383816
148MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91137517
149FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90587139
150MYB_26560356_Chip-Seq_TH1_Human0.90449072
151TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90027933
152CTCF_18555785_Chip-Seq_ESCs_Mouse0.90005562
153SRF_21415370_ChIP-Seq_HL-1_Mouse0.89686302
154VDR_23849224_ChIP-Seq_CD4+_Human0.89267530
155TFEB_21752829_ChIP-Seq_HELA_Human0.88763181
156NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87507124
157IGF1R_20145208_ChIP-Seq_DFB_Human0.86910890
158TP53_22573176_ChIP-Seq_HFKS_Human0.86084050

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.77034815
2MP0003136_yellow_coat_color3.98451756
3MP0008057_abnormal_DNA_replication3.49090272
4MP0005171_absent_coat_pigmentation3.02357022
5* MP0003950_abnormal_plasma_membrane2.96791121
6MP0003690_abnormal_glial_cell2.90338174
7MP0001529_abnormal_vocalization2.78488018
8MP0001485_abnormal_pinna_reflex2.63551140
9MP0004782_abnormal_surfactant_physiolog2.60166087
10MP0000383_abnormal_hair_follicle2.56545223
11MP0002009_preneoplasia2.55386958
12MP0005409_darkened_coat_color2.53658853
13MP0004147_increased_porphyrin_level2.50030243
14MP0004742_abnormal_vestibular_system2.46375578
15MP0004381_abnormal_hair_follicle2.42370753
16MP0005451_abnormal_body_composition2.41737792
17MP0010678_abnormal_skin_adnexa2.39444060
18MP0003806_abnormal_nucleotide_metabolis2.38290197
19MP0001905_abnormal_dopamine_level2.37463392
20MP0002163_abnormal_gland_morphology2.21870898
21MP0010234_abnormal_vibrissa_follicle2.20633668
22MP0000569_abnormal_digit_pigmentation2.18603324
23MP0003693_abnormal_embryo_hatching2.18009683
24MP0008007_abnormal_cellular_replicative2.07642600
25MP0008995_early_reproductive_senescence2.02487847
26MP0000566_synostosis1.99470054
27MP0003634_abnormal_glial_cell1.90373175
28MP0002928_abnormal_bile_duct1.84061466
29* MP0005410_abnormal_fertilization1.81874428
30MP0004142_abnormal_muscle_tone1.81570148
31MP0003632_abnormal_nervous_system1.80547432
32MP0003786_premature_aging1.80005446
33MP0003937_abnormal_limbs/digits/tail_de1.79503435
34MP0006054_spinal_hemorrhage1.79266496
35MP0004043_abnormal_pH_regulation1.78186851
36MP0010094_abnormal_chromosome_stability1.75183576
37MP0004885_abnormal_endolymph1.73911130
38MP0000462_abnormal_digestive_system1.72075534
39MP0002229_neurodegeneration1.62505499
40MP0002938_white_spotting1.61291247
41MP0002166_altered_tumor_susceptibility1.59613735
42MP0010307_abnormal_tumor_latency1.59589095
43MP0009785_altered_susceptibility_to1.59381912
44MP0003880_abnormal_central_pattern1.57635424
45MP0001346_abnormal_lacrimal_gland1.56367489
46MP0008260_abnormal_autophagy1.56171967
47MP0003724_increased_susceptibility_to1.54181723
48MP0004134_abnormal_chest_morphology1.53586850
49MP0002006_tumorigenesis1.52946615
50MP0001873_stomach_inflammation1.52621580
51MP0003938_abnormal_ear_development1.49709529
52MP0001853_heart_inflammation1.48595683
53MP0005084_abnormal_gallbladder_morpholo1.43411321
54MP0001486_abnormal_startle_reflex1.41989173
55MP0010352_gastrointestinal_tract_polyps1.40497456
56* MP0003656_abnormal_erythrocyte_physiolo1.40281418
57MP0003943_abnormal_hepatobiliary_system1.39767378
58MP0003718_maternal_effect1.39001645
59MP0001851_eye_inflammation1.38492524
60MP0000647_abnormal_sebaceous_gland1.37231446
61MP0008932_abnormal_embryonic_tissue1.36823989
62MP0003329_amyloid_beta_deposits1.36655835
63MP0005379_endocrine/exocrine_gland_phen1.36206852
64MP0000427_abnormal_hair_cycle1.35910935
65MP0004133_heterotaxia1.33988598
66MP0005167_abnormal_blood-brain_barrier1.33747385
67MP0002138_abnormal_hepatobiliary_system1.33692497
68MP0001800_abnormal_humoral_immune1.33339148
69MP0003890_abnormal_embryonic-extraembry1.32833467
70MP0004947_skin_inflammation1.30752296
71MP0009697_abnormal_copulation1.28234005
72MP0002405_respiratory_system_inflammati1.27885356
73MP0002148_abnormal_hypersensitivity_rea1.27700612
74MP0004270_analgesia1.27143132
75MP0000465_gastrointestinal_hemorrhage1.26302273
76MP0003252_abnormal_bile_duct1.26298252
77MP0005000_abnormal_immune_tolerance1.23708577
78MP0002272_abnormal_nervous_system1.23621712
79MP0005075_abnormal_melanosome_morpholog1.20721750
80MP0000778_abnormal_nervous_system1.20018159
81MP0008877_abnormal_DNA_methylation1.19775705
82MP0003111_abnormal_nucleus_morphology1.19632244
83MP0005408_hypopigmentation1.19049396
84MP0001293_anophthalmia1.15540650
85MP0000372_irregular_coat_pigmentation1.14889872
86MP0002723_abnormal_immune_serum1.13607027
87MP0001790_abnormal_immune_system1.13530205
88MP0005387_immune_system_phenotype1.13530205
89MP0009764_decreased_sensitivity_to1.13519636
90MP0004808_abnormal_hematopoietic_stem1.13143170
91MP0003077_abnormal_cell_cycle1.12760776
92MP0003763_abnormal_thymus_physiology1.12648888
93MP0005551_abnormal_eye_electrophysiolog1.12282416
94MP0000762_abnormal_tongue_morphology1.12094423
95MP0003631_nervous_system_phenotype1.10107002
96MP0001963_abnormal_hearing_physiology1.09836004
97MP0005174_abnormal_tail_pigmentation1.09492871
98MP0002452_abnormal_antigen_presenting1.09455497
99MP0005220_abnormal_exocrine_pancreas1.06870304
100MP0000467_abnormal_esophagus_morphology1.05394561
101MP0004185_abnormal_adipocyte_glucose1.04128621
102MP0005195_abnormal_posterior_eye1.03652392
103MP0006292_abnormal_olfactory_placode1.02470349
104MP0006082_CNS_inflammation1.01921099
105MP0000689_abnormal_spleen_morphology1.01864556
106MP0000685_abnormal_immune_system0.99617422
107MP0008058_abnormal_DNA_repair0.99315631
108MP0002098_abnormal_vibrissa_morphology0.98841340
109MP0001835_abnormal_antigen_presentation0.98400614
110MP0002420_abnormal_adaptive_immunity0.97780902
111MP0000579_abnormal_nail_morphology0.96828147
112MP0001819_abnormal_immune_cell0.95732442
113* MP0002398_abnormal_bone_marrow0.93146506
114MP0008875_abnormal_xenobiotic_pharmacok0.93067723
115MP0002132_abnormal_respiratory_system0.91155801
116MP0005671_abnormal_response_to0.90172691
117MP0002396_abnormal_hematopoietic_system0.89742567
118MP0001919_abnormal_reproductive_system0.89666886
119MP0003436_decreased_susceptibility_to0.88823899
120MP0002419_abnormal_innate_immunity0.88133654
121MP0000371_diluted_coat_color0.88117106
122* MP0001929_abnormal_gametogenesis0.87905472
123* MP0003698_abnormal_male_reproductive0.87664369
124MP0002752_abnormal_somatic_nervous0.86943125
125MP0001845_abnormal_inflammatory_respons0.86857082
126MP0004957_abnormal_blastocyst_morpholog0.86849059
127MP0002095_abnormal_skin_pigmentation0.85965851
128MP0005083_abnormal_biliary_tract0.85682550
129MP0002722_abnormal_immune_system0.85100369
130MP0006035_abnormal_mitochondrial_morpho0.84516695
131* MP0001216_abnormal_epidermal_layer0.83578575
132MP0000703_abnormal_thymus_morphology0.83520450
133MP0000631_abnormal_neuroendocrine_gland0.83326976
134MP0008961_abnormal_basal_metabolism0.82760975
135MP0001177_atelectasis0.81366012
136MP0003221_abnormal_cardiomyocyte_apopto0.81073796
137MP0001119_abnormal_female_reproductive0.80519103
138MP0008872_abnormal_physiological_respon0.80245958
139MP0005389_reproductive_system_phenotype0.80155171
140MP0001986_abnormal_taste_sensitivity0.79679310
141MP0002160_abnormal_reproductive_system0.79459487
142* MP0002019_abnormal_tumor_incidence0.78527871
143MP0005395_other_phenotype0.75715417
144MP0003186_abnormal_redox_activity0.75551827
145MP0000716_abnormal_immune_system0.75495212
146MP0000026_abnormal_inner_ear0.75016446
147MP0000955_abnormal_spinal_cord0.74983793
148MP0002210_abnormal_sex_determination0.74326108
149MP0000470_abnormal_stomach_morphology0.72818704
150MP0001145_abnormal_male_reproductive0.72457662
151MP0006072_abnormal_retinal_apoptosis0.71853388
152MP0005253_abnormal_eye_physiology0.71687299
153MP0001661_extended_life_span0.71096073
154MP0005058_abnormal_lysosome_morphology0.70119098
155MP0005391_vision/eye_phenotype0.68290424
156MP0003633_abnormal_nervous_system0.68214049
157MP0002882_abnormal_neuron_morphology0.65893776
158MP0004264_abnormal_extraembryonic_tissu0.64653893
159MP0000653_abnormal_sex_gland0.63381244
160MP0001188_hyperpigmentation0.63280194
161MP0000377_abnormal_hair_follicle0.62774354
162MP0005310_abnormal_salivary_gland0.62583707
163MP0002092_abnormal_eye_morphology0.62160918
164MP0003121_genomic_imprinting0.61211847
165MP0002277_abnormal_respiratory_mucosa0.56562014
166MP0000604_amyloidosis0.56425447
167MP0003453_abnormal_keratinocyte_physiol0.54092321
168MP0009333_abnormal_splenocyte_physiolog0.53071469
169MP0002102_abnormal_ear_morphology0.52312277
170MP0002085_abnormal_embryonic_tissue0.52195561
171MP0000613_abnormal_salivary_gland0.51195844
172MP0002233_abnormal_nose_morphology0.50790687
173MP0001243_abnormal_dermal_layer0.50663807
174MP0003195_calcinosis0.50460754

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.58781239
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.58781239
3Parakeratosis (HP:0001036)6.18442241
4Neurofibrillary tangles (HP:0002185)4.46049119
5Abnormality of the corticospinal tract (HP:0002492)4.38366483
6Cerebral hypomyelination (HP:0006808)4.37209561
7Sensory axonal neuropathy (HP:0003390)4.24350586
8Oral leukoplakia (HP:0002745)3.95530580
9Peripheral hypomyelination (HP:0007182)3.60046631
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.51361136
11Hypoplastic pelvis (HP:0008839)3.42806575
12* Abnormality of the pons (HP:0007361)3.13320553
13Hypoplasia of the pons (HP:0012110)3.13320553
14Abnormal auditory evoked potentials (HP:0006958)3.12294611
15White forelock (HP:0002211)3.10981575
16Patchy hypopigmentation of hair (HP:0011365)3.08543032
17Abnormality of the preputium (HP:0100587)2.93113886
18Autoamputation (HP:0001218)2.91872035
19Cerebral inclusion bodies (HP:0100314)2.82656322
20Pancreatic cysts (HP:0001737)2.81303296
21Congenital ichthyosiform erythroderma (HP:0007431)2.79635200
22Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.75933095
23Increased serum pyruvate (HP:0003542)2.73652030
24Abnormality of glycolysis (HP:0004366)2.73652030
25Esophageal atresia (HP:0002032)2.72300086
26CNS hypomyelination (HP:0003429)2.72240106
27Abnormality of the phalanges of the 2nd finger (HP:0009541)2.70397428
28Termporal pattern (HP:0011008)2.69588023
29Insidious onset (HP:0003587)2.69588023
30Onion bulb formation (HP:0003383)2.66587814
31Acute myeloid leukemia (HP:0004808)2.65939687
32Alacrima (HP:0000522)2.65325390
33Spastic gait (HP:0002064)2.64020633
34Anteriorly placed anus (HP:0001545)2.62176085
35Adrenal hypoplasia (HP:0000835)2.62136253
36Stomatitis (HP:0010280)2.61582908
37Premature skin wrinkling (HP:0100678)2.60253740
38Abnormality of T cell physiology (HP:0011840)2.59324722
39Blepharitis (HP:0000498)2.58527172
40Prolonged neonatal jaundice (HP:0006579)2.52393758
41Chromsome breakage (HP:0040012)2.50513782
42Autoimmune hemolytic anemia (HP:0001890)2.50105159
43Leukodystrophy (HP:0002415)2.48888851
44Morphological abnormality of the inner ear (HP:0011390)2.47602126
45Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47053687
46Duplication of thumb phalanx (HP:0009942)2.46759816
47Septo-optic dysplasia (HP:0100842)2.46452225
48Fatigue (HP:0012378)2.45728452
49Erythroderma (HP:0001019)2.44476843
50Slow saccadic eye movements (HP:0000514)2.42211693
51Abnormality of the renal cortex (HP:0011035)2.41084207
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.39675827
53* Absent septum pellucidum (HP:0001331)2.38439145
54Cupped ear (HP:0000378)2.34934861
55Myelodysplasia (HP:0002863)2.33958116
56Clubbing of toes (HP:0100760)2.32424685
57Asplenia (HP:0001746)2.32038605
58Fair hair (HP:0002286)2.27157050
59Abnormality of alanine metabolism (HP:0010916)2.25781230
60Hyperalaninemia (HP:0003348)2.25781230
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25781230
62Breast hypoplasia (HP:0003187)2.25274048
63Clumsiness (HP:0002312)2.23528780
64* Large for gestational age (HP:0001520)2.22174406
65Abnormality of T cells (HP:0002843)2.21377960
66Abnormality of the ileum (HP:0001549)2.20329438
67Decreased lacrimation (HP:0000633)2.19980542
683-Methylglutaconic aciduria (HP:0003535)2.19263582
69Stenosis of the external auditory canal (HP:0000402)2.19002863
70Segmental peripheral demyelination/remyelination (HP:0003481)2.18762882
71Azoospermia (HP:0000027)2.15650217
72Alveolar cell carcinoma (HP:0006519)2.14101491
73Retinal dysplasia (HP:0007973)2.13199839
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12975205
75Neoplasm of the tracheobronchial system (HP:0100552)2.11408028
76Meckel diverticulum (HP:0002245)2.10226596
77Hepatosplenomegaly (HP:0001433)2.10102584
78Gastrointestinal atresia (HP:0002589)2.10067619
79* Abnormality of the septum pellucidum (HP:0007375)2.09107857
80Spastic paraparesis (HP:0002313)2.05627805
81Ectropion (HP:0000656)2.02266734
82Aplasia/Hypoplasia of the spleen (HP:0010451)2.02036982
83Generalized hypopigmentation of hair (HP:0011358)2.01283849
84Pancreatic fibrosis (HP:0100732)1.99186108
85Thickened helices (HP:0000391)1.98358602
86Abnormality of the renal medulla (HP:0100957)1.97744696
87Partial duplication of thumb phalanx (HP:0009944)1.97663967
88Abnormality of T cell number (HP:0011839)1.97398240
89Increased hepatocellular lipid droplets (HP:0006565)1.96576930
90Molar tooth sign on MRI (HP:0002419)1.96155672
91Abnormality of midbrain morphology (HP:0002418)1.96155672
92* Abnormality of the renal collecting system (HP:0004742)1.95556948
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95525941
94Abnormal umbilical cord blood vessels (HP:0011403)1.95309971
95Single umbilical artery (HP:0001195)1.95309971
96Abnormality of the fetal cardiovascular system (HP:0010948)1.95309971
97Hypothermia (HP:0002045)1.93314904
98Stomach cancer (HP:0012126)1.91829793
99Exocrine pancreatic insufficiency (HP:0001738)1.90954013
100Akinesia (HP:0002304)1.90926162
101Medial flaring of the eyebrow (HP:0010747)1.90628756
102Anomalous pulmonary venous return (HP:0010772)1.90370070
103Chronic hepatic failure (HP:0100626)1.90280794
104True hermaphroditism (HP:0010459)1.89108867
105Exertional dyspnea (HP:0002875)1.88969464
106Abnormal pancreas size (HP:0012094)1.88836221
107Partial agenesis of the corpus callosum (HP:0001338)1.88701463
108Birth length less than 3rd percentile (HP:0003561)1.88597501
109Abnormality of B cell number (HP:0010975)1.87207962
110Ectopic kidney (HP:0000086)1.86872037
111* Duplicated collecting system (HP:0000081)1.86770517
112Clitoromegaly (HP:0000057)1.86596057
113Methylmalonic acidemia (HP:0002912)1.85871299
114Cerebellar dysplasia (HP:0007033)1.85539381
115Nasolacrimal duct obstruction (HP:0000579)1.85269503
116Cellular immunodeficiency (HP:0005374)1.84634038
117Renal Fanconi syndrome (HP:0001994)1.84557802
118Absent radius (HP:0003974)1.83902785
119Retrobulbar optic neuritis (HP:0100654)1.83828424
120Optic neuritis (HP:0100653)1.83828424
121Increased circulating renin level (HP:0000848)1.82924725
122Sloping forehead (HP:0000340)1.82698655
123Abnormality of the clitoris (HP:0000056)1.82524966
124Abnormality of the nasal septum (HP:0000419)1.82438098
125Concave nail (HP:0001598)1.82157731
126Prostate neoplasm (HP:0100787)1.81368179
127Sparse eyelashes (HP:0000653)1.81063559
128Volvulus (HP:0002580)1.80867925
129T lymphocytopenia (HP:0005403)1.80149157
130Nephroblastoma (Wilms tumor) (HP:0002667)1.79515444
131Abnormality of cochlea (HP:0000375)1.79180172
132Split foot (HP:0001839)1.77891501
133Metabolic alkalosis (HP:0200114)1.76744596
134B lymphocytopenia (HP:0010976)1.76113114
135Thyroiditis (HP:0100646)1.75963533
136Hypoplastic labia majora (HP:0000059)1.75948357
137Stridor (HP:0010307)1.75884802
138Breast carcinoma (HP:0003002)1.74582550
139Bone marrow hypocellularity (HP:0005528)1.74092909
140Abnormal spermatogenesis (HP:0008669)1.73837309
141Embryonal renal neoplasm (HP:0011794)1.73696218
142Furrowed tongue (HP:0000221)1.72710820
143Severe combined immunodeficiency (HP:0004430)1.71563916
144Carpal bone hypoplasia (HP:0001498)1.71485414
145Aplasia involving forearm bones (HP:0009822)1.69949139
146Absent forearm bone (HP:0003953)1.69949139
147Coronal craniosynostosis (HP:0004440)1.69885491
148Hypomagnesemia (HP:0002917)1.69814490
149Abnormal delayed hypersensitivity skin test (HP:0002963)1.69257980
150Autoimmune thrombocytopenia (HP:0001973)1.67987899
151Ketoacidosis (HP:0001993)1.67761263
152Papillary thyroid carcinoma (HP:0002895)1.67672857
153Constricted visual fields (HP:0001133)1.67475765
154Hypoproteinemia (HP:0003075)1.67359837
155Premature graying of hair (HP:0002216)1.67006466
156Congenital, generalized hypertrichosis (HP:0004540)1.65393201
157Nephronophthisis (HP:0000090)1.65196192
158Steatorrhea (HP:0002570)1.65169443
159Myelomeningocele (HP:0002475)1.65006861
160Abnormality of the pulmonary veins (HP:0011718)1.64742641
161Duodenal stenosis (HP:0100867)1.63745446
162Small intestinal stenosis (HP:0012848)1.63745446
163Lipid accumulation in hepatocytes (HP:0006561)1.63654295
164Abnormality of the labia minora (HP:0012880)1.63266110
165Alopecia of scalp (HP:0002293)1.63225271
166Abnormality of the umbilical cord (HP:0010881)1.62522948
167IgG deficiency (HP:0004315)1.62072149
168Abnormality of the salivary glands (HP:0010286)1.61457421
169Abnormality of eosinophils (HP:0001879)1.59716416
170Abnormality of the heme biosynthetic pathway (HP:0010472)1.59655811
171Abnormal biliary tract morphology (HP:0012440)1.58684597
172Poor speech (HP:0002465)1.58540754
173Abnormal drinking behavior (HP:0030082)1.58373703
174Polydipsia (HP:0001959)1.58373703
175Partial duplication of the phalanx of hand (HP:0009999)1.58253497
176Dysmetria (HP:0001310)1.58174408
177Abnormality of chromosome stability (HP:0003220)1.58134225
178Chin dimple (HP:0010751)1.57674018
179Abnormal lung lobation (HP:0002101)1.57623158
180Rhinitis (HP:0012384)1.57526635
181Premature ovarian failure (HP:0008209)1.57204447
182Intention tremor (HP:0002080)1.56877805
183Thyroid carcinoma (HP:0002890)1.56538729
184Progressive inability to walk (HP:0002505)1.56502021
185Abnormal biliary tract physiology (HP:0012439)1.55212720
186Bile duct proliferation (HP:0001408)1.55212720
187Hypoplasia of the capital femoral epiphysis (HP:0003090)1.54383594
188Small epiphyses (HP:0010585)1.54323384
189Increased serum lactate (HP:0002151)1.53033537
190Abnormality of renal resorption (HP:0011038)1.50005551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.75405509
2OXSR14.31003687
3PBK3.13679134
4MAPKAPK52.99503473
5BRSK22.98543439
6EPHB12.97806119
7MST42.48345905
8CDK192.32743426
9PDK22.27804693
10MET2.25839000
11CLK12.20606364
12BCR2.20353069
13EIF2AK12.20319346
14PKN12.19079472
15ERBB31.93187680
16FRK1.92609191
17MKNK11.92395399
18TRIM281.90148582
19WNK41.90124039
20BUB11.88970435
21TNIK1.79886692
22PNCK1.77172089
23WNK11.76290967
24NEK61.73827617
25CSNK1A1L1.70609954
26TESK21.60285846
27CSNK1G31.60235238
28STK161.59840398
29LMTK21.48838676
30VRK11.42772082
31MAP4K21.36713250
32CDC71.35711973
33CSNK1G11.31463788
34STK101.29405742
35TTK1.29133264
36LIMK11.27859597
37PRPF4B1.27837136
38EIF2AK31.27162516
39STK241.20767083
40IRAK11.18081047
41ACVR1B1.15194168
42MUSK1.14502242
43IKBKB1.13714594
44NLK1.12813295
45MKNK21.11363841
46CAMKK21.10011656
47FGFR21.09359936
48NEK11.08701754
49TGFBR11.07775189
50FGR1.06820893
51UHMK11.06578559
52RPS6KA51.06434588
53SIK31.02827744
54ROCK21.02612644
55TRPM71.00730505
56CAMK2B1.00146371
57MAP3K20.98711076
58DYRK20.96084408
59CSNK1G20.95406011
60WEE10.93893827
61MARK30.90760990
62NUAK10.86409358
63SRPK10.83220206
64BMPR1B0.81609115
65TEC0.80791558
66CHEK20.79847843
67AKT30.78946863
68CHUK0.78056680
69PRKCQ0.76614635
70PLK40.75192208
71CAMK2D0.74778805
72BRD40.74547050
73LATS10.73783376
74IKBKE0.73780765
75MAPK150.69987707
76ZAK0.69897348
77TAOK30.69738554
78BLK0.69688891
79ERBB40.68768592
80FGFR10.67739222
81STK38L0.67312734
82CSNK1D0.65409818
83PASK0.65060776
84PIM10.64503103
85TLK10.63868741
86WNK30.62817057
87ADRBK20.62416198
88SGK4940.62396142
89SGK2230.62396142
90GRK10.61849940
91GRK70.60905466
92MARK20.60725518
93MELK0.60456897
94STK40.59307309
95DYRK30.56953020
96IRAK20.55385957
97YES10.55089250
98MAP3K140.54841221
99RPS6KB20.53389711
100BRSK10.50971033
101KSR10.50838114
102CDK150.49710441
103IRAK30.49202714
104PAK10.48741199
105TAF10.48696950
106PLK30.48669698
107CAMK2G0.48639230
108PAK30.48387560
109FLT30.47250111
110MAPK70.47203666
111MAPKAPK30.46796028
112CDK11A0.46430123
113TXK0.45918573
114CHEK10.45678351
115CDK180.45042180
116CDK140.44710330
117STK30.44348014
118ATM0.42130595
119CDK30.41720125
120IRAK40.41567931
121ATR0.41565181
122ITK0.41176207
123LCK0.40456824
124MAP2K20.40205616
125CSNK1A10.40039185
126FER0.39709131
127BMPR20.38754797
128PLK10.38281915
129FGFR30.38124196
130MAP3K120.37109796
131CSF1R0.36751214
132EIF2AK20.36541919
133CDK10.35873949
134PRKCI0.35394193
135DMPK0.34755856
136AURKA0.33858321
137MAPKAPK20.33789739
138MAP3K80.32451129
139CAMK2A0.32380735
140NTRK10.32036934
141MAP3K40.31776679
142CDK60.30360100
143CDK70.28766157
144TSSK60.28618920
145PIK3CA0.26441482
146MAP3K90.25912692
147CCNB10.24655027
148ABL10.24321877

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.07701388
2Steroid biosynthesis_Homo sapiens_hsa001004.93324780
3Fatty acid elongation_Homo sapiens_hsa000624.32640660
4Protein export_Homo sapiens_hsa030603.41092914
5Ether lipid metabolism_Homo sapiens_hsa005653.18709060
6* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.12790019
7Vitamin B6 metabolism_Homo sapiens_hsa007502.50831708
8Circadian rhythm_Homo sapiens_hsa047102.37239717
9Non-homologous end-joining_Homo sapiens_hsa034502.30711250
10Sphingolipid metabolism_Homo sapiens_hsa006002.24413613
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20382034
12Nitrogen metabolism_Homo sapiens_hsa009102.14287252
13Legionellosis_Homo sapiens_hsa051342.12322260
14Selenocompound metabolism_Homo sapiens_hsa004502.11704402
15Sulfur metabolism_Homo sapiens_hsa009202.05000615
16Linoleic acid metabolism_Homo sapiens_hsa005912.01660426
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.99773961
18RNA polymerase_Homo sapiens_hsa030201.89070617
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.84324839
20Histidine metabolism_Homo sapiens_hsa003401.80422040
21Basal transcription factors_Homo sapiens_hsa030221.76118397
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66906554
23Homologous recombination_Homo sapiens_hsa034401.65436599
24DNA replication_Homo sapiens_hsa030301.63851928
25Measles_Homo sapiens_hsa051621.63253861
26Mismatch repair_Homo sapiens_hsa034301.54072482
27Folate biosynthesis_Homo sapiens_hsa007901.50381707
28Propanoate metabolism_Homo sapiens_hsa006401.50218177
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.43732030
30Fanconi anemia pathway_Homo sapiens_hsa034601.43564357
31TNF signaling pathway_Homo sapiens_hsa046681.43453125
32Arachidonic acid metabolism_Homo sapiens_hsa005901.31871949
33Herpes simplex infection_Homo sapiens_hsa051681.24280842
34Nucleotide excision repair_Homo sapiens_hsa034201.24267616
35Arginine and proline metabolism_Homo sapiens_hsa003301.23308426
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22935803
37Caffeine metabolism_Homo sapiens_hsa002321.22231009
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20690756
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.19224562
40T cell receptor signaling pathway_Homo sapiens_hsa046601.18292353
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17015328
42Glutathione metabolism_Homo sapiens_hsa004801.16096199
43Cell cycle_Homo sapiens_hsa041101.13408491
44Spliceosome_Homo sapiens_hsa030401.10337961
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07732164
46Autoimmune thyroid disease_Homo sapiens_hsa053201.06390196
47Vitamin digestion and absorption_Homo sapiens_hsa049771.00251279
48RNA degradation_Homo sapiens_hsa030180.99789855
49Influenza A_Homo sapiens_hsa051640.98798951
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97642223
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.95796781
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90870953
53Epstein-Barr virus infection_Homo sapiens_hsa051690.90223984
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90077500
55Base excision repair_Homo sapiens_hsa034100.90048030
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87085598
57Tryptophan metabolism_Homo sapiens_hsa003800.84465190
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.81308666
59One carbon pool by folate_Homo sapiens_hsa006700.80919141
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77074501
61Antigen processing and presentation_Homo sapiens_hsa046120.76332144
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75777737
63FoxO signaling pathway_Homo sapiens_hsa040680.75188246
64Axon guidance_Homo sapiens_hsa043600.74929005
65Purine metabolism_Homo sapiens_hsa002300.74604138
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72890806
67Pyrimidine metabolism_Homo sapiens_hsa002400.71639964
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71248369
69Butanoate metabolism_Homo sapiens_hsa006500.71197283
70Type I diabetes mellitus_Homo sapiens_hsa049400.70292816
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.69242935
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68962876
73Collecting duct acid secretion_Homo sapiens_hsa049660.68060100
74Leishmaniasis_Homo sapiens_hsa051400.67850433
75Oxidative phosphorylation_Homo sapiens_hsa001900.67791071
76Proteasome_Homo sapiens_hsa030500.67067094
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66559504
78Osteoclast differentiation_Homo sapiens_hsa043800.65387429
79Phototransduction_Homo sapiens_hsa047440.63630036
80Systemic lupus erythematosus_Homo sapiens_hsa053220.63550656
81Renal cell carcinoma_Homo sapiens_hsa052110.63126293
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61791643
83Ovarian steroidogenesis_Homo sapiens_hsa049130.61640348
84ABC transporters_Homo sapiens_hsa020100.59666737
85* Metabolic pathways_Homo sapiens_hsa011000.59233193
86Mineral absorption_Homo sapiens_hsa049780.58637746
87Hepatitis B_Homo sapiens_hsa051610.58005677
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56457753
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.55785420
90RNA transport_Homo sapiens_hsa030130.54054821
91Primary immunodeficiency_Homo sapiens_hsa053400.53116203
92Toxoplasmosis_Homo sapiens_hsa051450.52815432
93Pancreatic secretion_Homo sapiens_hsa049720.51610951
94Dorso-ventral axis formation_Homo sapiens_hsa043200.51251928
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50323580
96mRNA surveillance pathway_Homo sapiens_hsa030150.49636657
97Tight junction_Homo sapiens_hsa045300.49352622
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48333872
99Apoptosis_Homo sapiens_hsa042100.47418993
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45848194
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45552707
102Serotonergic synapse_Homo sapiens_hsa047260.44882146
103Other glycan degradation_Homo sapiens_hsa005110.41437530
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.41359626
105Pertussis_Homo sapiens_hsa051330.40407199
106Lysosome_Homo sapiens_hsa041420.40126246
107Lysine degradation_Homo sapiens_hsa003100.40057748
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39920303
109Glycerolipid metabolism_Homo sapiens_hsa005610.39163438
110B cell receptor signaling pathway_Homo sapiens_hsa046620.36542374
111Retinol metabolism_Homo sapiens_hsa008300.36085342
112Graft-versus-host disease_Homo sapiens_hsa053320.36009689
113Malaria_Homo sapiens_hsa051440.35868399
114Parkinsons disease_Homo sapiens_hsa050120.35143152
115Rheumatoid arthritis_Homo sapiens_hsa053230.34549442
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34143701
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33977056
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32679190
119Alzheimers disease_Homo sapiens_hsa050100.32336187
120HIF-1 signaling pathway_Homo sapiens_hsa040660.32231645
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32011578
122Insulin resistance_Homo sapiens_hsa049310.31426634
123Viral carcinogenesis_Homo sapiens_hsa052030.30971259
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30803199
125Peroxisome_Homo sapiens_hsa041460.30158967
126Asthma_Homo sapiens_hsa053100.29862551
127Renin-angiotensin system_Homo sapiens_hsa046140.29675796
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.29342215
129Hematopoietic cell lineage_Homo sapiens_hsa046400.29045077
130Phagosome_Homo sapiens_hsa041450.28369975
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28007476
132Ribosome_Homo sapiens_hsa030100.27792556
133Alcoholism_Homo sapiens_hsa050340.26907302
134Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26854099
135Regulation of autophagy_Homo sapiens_hsa041400.26398240
136Ras signaling pathway_Homo sapiens_hsa040140.25884522
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25143171
138Chemical carcinogenesis_Homo sapiens_hsa052040.24832862
139Prostate cancer_Homo sapiens_hsa052150.24672898
140NF-kappa B signaling pathway_Homo sapiens_hsa040640.24641881
141p53 signaling pathway_Homo sapiens_hsa041150.22186208
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20646610
143Hedgehog signaling pathway_Homo sapiens_hsa043400.17534100
144Allograft rejection_Homo sapiens_hsa053300.17474748
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16523701
146TGF-beta signaling pathway_Homo sapiens_hsa043500.15581630

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