PIGB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)7.05553553
2presynaptic membrane assembly (GO:0097105)6.58493034
3DNA deamination (GO:0045006)4.79554204
4neural tube formation (GO:0001841)4.65635402
5response to pheromone (GO:0019236)4.63417285
6respiratory chain complex IV assembly (GO:0008535)4.14321517
7long-chain fatty acid biosynthetic process (GO:0042759)3.87728727
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.87345656
9cytochrome complex assembly (GO:0017004)3.83907875
10fucose catabolic process (GO:0019317)3.82390391
11L-fucose metabolic process (GO:0042354)3.82390391
12L-fucose catabolic process (GO:0042355)3.82390391
13central nervous system myelination (GO:0022010)3.78214289
14axon ensheathment in central nervous system (GO:0032291)3.78214289
15energy homeostasis (GO:0097009)3.74274857
16negative regulation of synaptic transmission, GABAergic (GO:0032229)3.72726967
17* mannosylation (GO:0097502)3.70704861
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.65360017
19neuron cell-cell adhesion (GO:0007158)3.64281572
20cytidine deamination (GO:0009972)3.64160755
21cytidine metabolic process (GO:0046087)3.64160755
22cytidine catabolic process (GO:0006216)3.64160755
23regulation of B cell receptor signaling pathway (GO:0050855)3.55311064
24neuronal action potential propagation (GO:0019227)3.52648387
25NIK/NF-kappaB signaling (GO:0038061)3.49959633
26postsynaptic membrane organization (GO:0001941)3.48590060
27behavioral response to ethanol (GO:0048149)3.48375613
28regulation of RIG-I signaling pathway (GO:0039535)3.42319382
29behavioral response to nicotine (GO:0035095)3.37088255
30* GPI anchor biosynthetic process (GO:0006506)3.34132463
31glutamate receptor signaling pathway (GO:0007215)3.33206733
32pyrimidine ribonucleoside catabolic process (GO:0046133)3.33082739
33protein complex biogenesis (GO:0070271)3.31098935
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.30981627
35indole-containing compound catabolic process (GO:0042436)3.28089038
36indolalkylamine catabolic process (GO:0046218)3.28089038
37tryptophan catabolic process (GO:0006569)3.28089038
38* GPI anchor metabolic process (GO:0006505)3.27021286
39synaptic transmission, glutamatergic (GO:0035249)3.24320430
40cornea development in camera-type eye (GO:0061303)3.23561867
41membrane assembly (GO:0071709)3.21817683
42necroptotic process (GO:0070266)3.20398522
43positive regulation of synapse assembly (GO:0051965)3.19180056
44L-amino acid import (GO:0043092)3.17822719
45somite development (GO:0061053)3.10725493
46regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.08092794
47nucleoside diphosphate catabolic process (GO:0009134)3.06702975
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.06330675
49regulation of protein polyubiquitination (GO:1902914)3.02030777
50kynurenine metabolic process (GO:0070189)2.99669129
51adult feeding behavior (GO:0008343)2.98925599
52gamma-aminobutyric acid signaling pathway (GO:0007214)2.98835455
53negative regulation of mast cell activation (GO:0033004)2.92318700
54protein localization to synapse (GO:0035418)2.91958847
55positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.90256382
56regulation of uterine smooth muscle contraction (GO:0070472)2.89998652
57respiratory electron transport chain (GO:0022904)2.88534860
58indolalkylamine metabolic process (GO:0006586)2.88252632
59purinergic nucleotide receptor signaling pathway (GO:0035590)2.87284042
60mitotic cell cycle arrest (GO:0071850)2.87177674
61platelet dense granule organization (GO:0060155)2.86572580
62regulation of regulatory T cell differentiation (GO:0045589)2.85211296
63neuron remodeling (GO:0016322)2.83803070
64neuron-neuron synaptic transmission (GO:0007270)2.82281391
65positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.81607105
66electron transport chain (GO:0022900)2.78034705
67energy coupled proton transport, down electrochemical gradient (GO:0015985)2.77273226
68ATP synthesis coupled proton transport (GO:0015986)2.77273226
69protein heterotetramerization (GO:0051290)2.77032591
70negative regulation of cell killing (GO:0031342)2.76194937
71negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.76194937
72tryptophan metabolic process (GO:0006568)2.75855690
73mitochondrial respiratory chain complex assembly (GO:0033108)2.75070179
74mast cell degranulation (GO:0043303)2.74425030
75mast cell activation involved in immune response (GO:0002279)2.74425030
76embryonic epithelial tube formation (GO:0001838)2.74397618
77positive regulation of synaptic transmission, GABAergic (GO:0032230)2.74163374
78* preassembly of GPI anchor in ER membrane (GO:0016254)2.72798205
79regulation of alpha-beta T cell proliferation (GO:0046640)2.72608652
80negative regulation of neurotransmitter transport (GO:0051589)2.72467288
81transmission of nerve impulse (GO:0019226)2.72332620
82startle response (GO:0001964)2.69531262
83cellular response to interleukin-15 (GO:0071350)2.69270181
84deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.67751130
85positive regulation of action potential (GO:0045760)2.67179302
86regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.66471353
87cerebral cortex radially oriented cell migration (GO:0021799)2.66008006
88mast cell activation (GO:0045576)2.65677585
89positive regulation of uterine smooth muscle contraction (GO:0070474)2.65373590
90mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.64109453
91positive regulation of gamma-delta T cell activation (GO:0046645)2.63405325
92* C-terminal protein amino acid modification (GO:0018410)2.60486846
93activated T cell proliferation (GO:0050798)2.60483843
94tolerance induction (GO:0002507)2.59843277
95mesenchymal cell differentiation involved in kidney development (GO:0072161)2.59659953
96mesenchymal cell differentiation involved in renal system development (GO:2001012)2.59659953
97nonmotile primary cilium assembly (GO:0035058)2.59570362
98amino acid import (GO:0043090)2.59257837
99regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.59111944
100vocalization behavior (GO:0071625)2.58546049
101negative regulation of transcription regulatory region DNA binding (GO:2000678)2.58182975
102import into cell (GO:0098657)2.57880850
103regulation of synapse assembly (GO:0051963)2.57607644
104programmed necrotic cell death (GO:0097300)2.56296778
105neurotransmitter uptake (GO:0001504)2.55310088
106eye photoreceptor cell differentiation (GO:0001754)2.55233640
107photoreceptor cell differentiation (GO:0046530)2.55233640
108regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.54231255
109regulation of synaptic transmission, GABAergic (GO:0032228)2.54056701
110G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52019313
111regulation of short-term neuronal synaptic plasticity (GO:0048172)2.51461327
112water-soluble vitamin biosynthetic process (GO:0042364)2.50519999
113mitochondrial respiratory chain complex I assembly (GO:0032981)2.50356843
114NADH dehydrogenase complex assembly (GO:0010257)2.50356843
115mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50356843
116piRNA metabolic process (GO:0034587)2.49145022
117epithelial cilium movement (GO:0003351)2.48977077
118keratinocyte development (GO:0003334)2.48542255
119axoneme assembly (GO:0035082)2.47050150
120positive regulation of alpha-beta T cell proliferation (GO:0046641)2.46986426
121negative regulation of interleukin-1 beta production (GO:0032691)2.46839736
122microglial cell activation (GO:0001774)2.46589926
123epithelial tube formation (GO:0072175)2.46533611
124response to redox state (GO:0051775)2.46489211
125photoreceptor cell maintenance (GO:0045494)2.46437873
126* C-terminal protein lipidation (GO:0006501)2.44805065
127positive regulation of defense response to virus by host (GO:0002230)2.43521008
128negative T cell selection (GO:0043383)2.43006712
129regulation of memory T cell differentiation (GO:0043380)2.42672239
130negative regulation of myoblast differentiation (GO:0045662)2.42597793
131necrotic cell death (GO:0070265)2.42296063
132regulation of inositol phosphate biosynthetic process (GO:0010919)2.41672907
133dopamine transport (GO:0015872)2.41142786
134negative regulation of exocytosis (GO:0045920)2.39890569
135epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.39784236
136limb bud formation (GO:0060174)2.39448459
137detection of calcium ion (GO:0005513)2.37656356
138estrogen biosynthetic process (GO:0006703)2.37402894
139positive regulation of interleukin-1 beta secretion (GO:0050718)2.37239148
140tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.36580345
141RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.36580345
142negative thymic T cell selection (GO:0045060)2.36473179
143RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.36458793
144regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.36060577
145positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.36017735
146ubiquinone biosynthetic process (GO:0006744)2.35946402
147quinone biosynthetic process (GO:1901663)2.35946402
148regulation of catecholamine metabolic process (GO:0042069)2.35916182
149regulation of dopamine metabolic process (GO:0042053)2.35916182
150chaperone-mediated protein transport (GO:0072321)2.35779550
151positive regulation of T-helper 1 type immune response (GO:0002827)2.35776976
152rRNA methylation (GO:0031167)2.35073936
153regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.35058380
154regulation of long-term neuronal synaptic plasticity (GO:0048169)2.34520715
155negative regulation of interleukin-1 production (GO:0032692)2.34508262
156regulation of excitatory postsynaptic membrane potential (GO:0060079)2.34308959
157adult walking behavior (GO:0007628)2.34000450
158regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.33795118
159neutrophil activation (GO:0042119)2.33586853
160righting reflex (GO:0060013)2.33420109
161sulfation (GO:0051923)2.32524084
162protein K11-linked deubiquitination (GO:0035871)2.32437567
163CTP metabolic process (GO:0046036)2.32109413
164CTP biosynthetic process (GO:0006241)2.32109413
165polyol transport (GO:0015791)2.32060785
166negative regulation of neurotransmitter secretion (GO:0046929)2.31626431
167positive regulation of T cell mediated cytotoxicity (GO:0001916)2.31543394
168reflex (GO:0060004)2.31287671
169regulation of T cell receptor signaling pathway (GO:0050856)2.31062443
170negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.30875931
171regulation of T cell mediated cytotoxicity (GO:0001914)2.30642761
172detection of light stimulus involved in sensory perception (GO:0050962)2.29845757
173detection of light stimulus involved in visual perception (GO:0050908)2.29845757
174GTP biosynthetic process (GO:0006183)2.29312519
175interferon-gamma production (GO:0032609)2.28148181
176signal peptide processing (GO:0006465)2.27765621
177regulation of rhodopsin mediated signaling pathway (GO:0022400)2.27720366
178cellular biogenic amine catabolic process (GO:0042402)2.27636560
179amine catabolic process (GO:0009310)2.27636560
180response to interleukin-15 (GO:0070672)2.26489645
181regulation of interleukin-1 beta secretion (GO:0050706)2.26222962
182fatty acid elongation (GO:0030497)2.25320631
183positive regulation of membrane potential (GO:0045838)2.24839857
184cranial nerve development (GO:0021545)2.23442215
185sphingoid metabolic process (GO:0046519)2.23073384
186rhodopsin mediated signaling pathway (GO:0016056)2.22470753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.27912079
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.02630105
3ZNF274_21170338_ChIP-Seq_K562_Hela3.70070371
4EZH2_22144423_ChIP-Seq_EOC_Human3.54184960
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.20881878
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.73733291
7TAF15_26573619_Chip-Seq_HEK293_Human2.70850927
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.43247324
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35658405
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31438697
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27220659
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.26165404
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25184161
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23065135
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18329258
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16092794
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11942155
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.11231521
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08893558
20P300_19829295_ChIP-Seq_ESCs_Human2.08682069
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07650460
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.05601945
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.01672583
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98356601
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93984633
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91720856
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91196075
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.88361098
29IRF1_19129219_ChIP-ChIP_H3396_Human1.85387713
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84766954
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.83922383
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83120354
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.82536273
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.80464980
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77907611
36FUS_26573619_Chip-Seq_HEK293_Human1.77600261
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.75169634
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.74463459
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74098574
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74098574
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73705159
42VDR_22108803_ChIP-Seq_LS180_Human1.73254574
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73006791
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.69450717
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.69066319
46IGF1R_20145208_ChIP-Seq_DFB_Human1.68380558
47GATA3_26560356_Chip-Seq_TH2_Human1.68088583
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67276721
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.65398345
50SMAD4_21799915_ChIP-Seq_A2780_Human1.64944601
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.64814839
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64525297
53AR_21572438_ChIP-Seq_LNCaP_Human1.64000017
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61392620
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.60237168
56GATA1_22025678_ChIP-Seq_K562_Human1.58315031
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58171517
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56699302
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56192631
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52730771
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51873940
62BCAT_22108803_ChIP-Seq_LS180_Human1.50898139
63REST_21632747_ChIP-Seq_MESCs_Mouse1.50333964
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.49771087
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49696115
66ER_23166858_ChIP-Seq_MCF-7_Human1.49498435
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49482887
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49196670
69RUNX_20019798_ChIP-Seq_JUKART_Human1.48103173
70P53_22387025_ChIP-Seq_ESCs_Mouse1.48083930
71* VDR_23849224_ChIP-Seq_CD4+_Human1.48059907
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47982704
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.47046169
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.45968536
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44354636
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.42427720
77* SOX2_19829295_ChIP-Seq_ESCs_Human1.42045316
78* NANOG_19829295_ChIP-Seq_ESCs_Human1.42045316
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40889667
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39862197
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39429642
82TP53_22573176_ChIP-Seq_HFKS_Human1.39225078
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.38194174
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38059525
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.37977966
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36067832
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.35240103
88CBP_20019798_ChIP-Seq_JUKART_Human1.34844145
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34844145
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34800247
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34374681
92RNF2_27304074_Chip-Seq_NSC_Mouse1.33721889
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33349035
94* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33240325
95* FOXA1_25329375_ChIP-Seq_VCAP_Human1.33240325
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.33109748
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32053487
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30506875
99* ELK1_19687146_ChIP-ChIP_HELA_Human1.29985751
100EST1_17652178_ChIP-ChIP_JURKAT_Human1.29948298
101RUNX1_27457419_Chip-Seq_LIVER_Mouse1.29690107
102GATA3_27048872_Chip-Seq_THYMUS_Human1.29631549
103KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28852163
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28818884
105P300_18555785_Chip-Seq_ESCs_Mouse1.27776316
106NMYC_18555785_Chip-Seq_ESCs_Mouse1.27589770
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27018977
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26539484
109LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26212429
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25294905
111GATA3_21878914_ChIP-Seq_MCF-7_Human1.24514201
112* AR_20517297_ChIP-Seq_VCAP_Human1.24321712
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23377318
114SOX2_18555785_Chip-Seq_ESCs_Mouse1.23041004
115MYB_26560356_Chip-Seq_TH2_Human1.22949283
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20612813
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19417457
118ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19160948
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.19042592
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18925618
121AR_25329375_ChIP-Seq_VCAP_Human1.18396751
122MYC_18940864_ChIP-ChIP_HL60_Human1.17934722
123DROSHA_22980978_ChIP-Seq_HELA_Human1.16439414
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15930046
125EWS_26573619_Chip-Seq_HEK293_Human1.14830516
126GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.14115297
127HTT_18923047_ChIP-ChIP_STHdh_Human1.14017959
128RUNX2_22187159_ChIP-Seq_PCA_Human1.13973205
129OCT4_18555785_Chip-Seq_ESCs_Mouse1.12895880
130TCF4_23295773_ChIP-Seq_U87_Human1.12880809
131POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11558440
132P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11517366
133PRDM14_20953172_ChIP-Seq_ESCs_Human1.11013521
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10527301
135STAT3_23295773_ChIP-Seq_U87_Human1.10356106
136SMAD1_18555785_Chip-Seq_ESCs_Mouse1.10287977
137SCL_19346495_ChIP-Seq_HPC-7_Human1.10134857
138PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09512547
139PU1_27457419_Chip-Seq_LIVER_Mouse1.08661504
140CTCF_18555785_Chip-Seq_ESCs_Mouse1.07919904
141AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06633939
142KLF4_18555785_Chip-Seq_ESCs_Mouse1.06546550
143CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06146536
144* KDM2B_26808549_Chip-Seq_REH_Human1.05728120
145NCOR_22424771_ChIP-Seq_293T_Human1.05559612
146SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05517727
147ZFX_18555785_Chip-Seq_ESCs_Mouse1.05439655
148TP53_18474530_ChIP-ChIP_U2OS_Human1.05028374
149NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04691295
150GATA3_26560356_Chip-Seq_TH1_Human1.04109255
151TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03957517
152RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03518878
153KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02572718
154FLI1_21867929_ChIP-Seq_TH2_Mouse1.01892826
155ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01861268
156OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01826144
157SRF_21415370_ChIP-Seq_HL-1_Mouse1.01607138
158JUN_21703547_ChIP-Seq_K562_Human1.00737862
159TCF4_22108803_ChIP-Seq_LS180_Human1.00647942
160PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99440240
161CDX2_22108803_ChIP-Seq_LS180_Human0.98471100
162SMRT_27268052_Chip-Seq_Bcells_Human0.98454184

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.00595283
2MP0009379_abnormal_foot_pigmentation3.99632581
3MP0001188_hyperpigmentation3.31955727
4MP0005409_darkened_coat_color2.90399992
5MP0004859_abnormal_synaptic_plasticity2.74492416
6MP0005671_abnormal_response_to2.71831877
7MP0005171_absent_coat_pigmentation2.55369121
8MP0008877_abnormal_DNA_methylation2.48855115
9MP0006292_abnormal_olfactory_placode2.47142596
10MP0001968_abnormal_touch/_nociception2.40664059
11MP0002837_dystrophic_cardiac_calcinosis2.40330263
12MP0001835_abnormal_antigen_presentation2.33003906
13MP0000569_abnormal_digit_pigmentation2.32804534
14MP0003635_abnormal_synaptic_transmissio2.32166864
15MP0005423_abnormal_somatic_nervous2.28945222
16MP0001986_abnormal_taste_sensitivity2.23409246
17MP0003787_abnormal_imprinting2.21800975
18MP0010386_abnormal_urinary_bladder2.21461474
19MP0002735_abnormal_chemical_nociception2.19983502
20MP0002272_abnormal_nervous_system2.19373854
21MP0009745_abnormal_behavioral_response2.18707337
22MP0002736_abnormal_nociception_after2.09517012
23MP0002572_abnormal_emotion/affect_behav2.08592156
24MP0005645_abnormal_hypothalamus_physiol2.08061420
25MP0002064_seizures2.05702033
26MP0003011_delayed_dark_adaptation2.01181878
27MP0001800_abnormal_humoral_immune2.01052784
28MP0005646_abnormal_pituitary_gland1.96463313
29MP0009046_muscle_twitch1.95909093
30MP0001905_abnormal_dopamine_level1.94323053
31MP0001486_abnormal_startle_reflex1.91231893
32MP0001529_abnormal_vocalization1.86091634
33MP0003646_muscle_fatigue1.85619970
34MP0005075_abnormal_melanosome_morpholog1.83586039
35MP0002876_abnormal_thyroid_physiology1.83382235
36MP0000685_abnormal_immune_system1.78405905
37MP0002148_abnormal_hypersensitivity_rea1.76677167
38MP0005551_abnormal_eye_electrophysiolog1.74479963
39MP0002102_abnormal_ear_morphology1.71750962
40MP0002063_abnormal_learning/memory/cond1.70786540
41MP0001984_abnormal_olfaction1.69457381
42MP0002138_abnormal_hepatobiliary_system1.69348475
43MP0002723_abnormal_immune_serum1.68213252
44MP0006276_abnormal_autonomic_nervous1.65033308
45MP0004270_analgesia1.64689819
46MP0002067_abnormal_sensory_capabilities1.64507505
47MP0005000_abnormal_immune_tolerance1.63378628
48MP0009785_altered_susceptibility_to1.59093424
49MP0001970_abnormal_pain_threshold1.58457715
50MP0001440_abnormal_grooming_behavior1.56008094
51MP0001501_abnormal_sleep_pattern1.54571328
52MP0000566_synostosis1.54407063
53MP0005379_endocrine/exocrine_gland_phen1.53735666
54MP0005387_immune_system_phenotype1.53353687
55MP0001790_abnormal_immune_system1.53353687
56MP0000920_abnormal_myelination1.53021273
57MP0004147_increased_porphyrin_level1.51902670
58MP0003763_abnormal_thymus_physiology1.51884924
59MP0002638_abnormal_pupillary_reflex1.50261517
60MP0001819_abnormal_immune_cell1.49290863
61MP0008872_abnormal_physiological_respon1.49134235
62MP0002452_abnormal_antigen_presenting1.49100472
63MP0002420_abnormal_adaptive_immunity1.49093678
64MP0000015_abnormal_ear_pigmentation1.47564731
65MP0002734_abnormal_mechanical_nocicepti1.45948823
66MP0004381_abnormal_hair_follicle1.45619682
67MP0000678_abnormal_parathyroid_gland1.45214530
68MP0009697_abnormal_copulation1.45149585
69MP0004142_abnormal_muscle_tone1.43399573
70MP0002733_abnormal_thermal_nociception1.42684226
71MP0003191_abnormal_cellular_cholesterol1.40275417
72MP0009764_decreased_sensitivity_to1.39311846
73MP0002928_abnormal_bile_duct1.37870986
74MP0003252_abnormal_bile_duct1.37012105
75MP0003136_yellow_coat_color1.36837788
76MP0006072_abnormal_retinal_apoptosis1.34799249
77MP0001502_abnormal_circadian_rhythm1.33858137
78MP0002557_abnormal_social/conspecific_i1.32016056
79MP0003183_abnormal_peptide_metabolism1.29475974
80MP0005025_abnormal_response_to1.27177628
81MP0008875_abnormal_xenobiotic_pharmacok1.26863610
82MP0005083_abnormal_biliary_tract1.23220185
83MP0003866_abnormal_defecation1.23125770
84MP0008995_early_reproductive_senescence1.22508468
85MP0002166_altered_tumor_susceptibility1.21375335
86MP0005464_abnormal_platelet_physiology1.19488774
87MP0004742_abnormal_vestibular_system1.19200086
88MP0000383_abnormal_hair_follicle1.17870158
89MP0000689_abnormal_spleen_morphology1.17190558
90MP0002009_preneoplasia1.17112245
91MP0001963_abnormal_hearing_physiology1.16881402
92MP0002822_catalepsy1.15709134
93MP0002419_abnormal_innate_immunity1.14698426
94MP0002277_abnormal_respiratory_mucosa1.14289817
95MP0002184_abnormal_innervation1.12667854
96MP0004885_abnormal_endolymph1.11484914
97MP0000778_abnormal_nervous_system1.11376831
98MP0000716_abnormal_immune_system1.11281742
99MP0005389_reproductive_system_phenotype1.11164977
100MP0001764_abnormal_homeostasis1.09768210
101MP0002938_white_spotting1.09295710
102MP0001845_abnormal_inflammatory_respons1.08561884
103MP0002909_abnormal_adrenal_gland1.07937255
104MP0000427_abnormal_hair_cycle1.07541730
105MP0002229_neurodegeneration1.07420060
106MP0005253_abnormal_eye_physiology1.07349641
107MP0003718_maternal_effect1.06857348
108MP0003806_abnormal_nucleotide_metabolis1.06315763
109MP0003786_premature_aging1.06163037
110MP0002163_abnormal_gland_morphology1.04995597
111MP0000026_abnormal_inner_ear1.03571018
112MP0002398_abnormal_bone_marrow1.03378700
113MP0000465_gastrointestinal_hemorrhage1.03249389
114MP0003436_decreased_susceptibility_to1.03119681
115MP0001873_stomach_inflammation1.02012017
116MP0001485_abnormal_pinna_reflex1.01447329
117MP0000631_abnormal_neuroendocrine_gland1.01313663
118MP0001664_abnormal_digestion1.01157394
119MP0005503_abnormal_tendon_morphology1.00614340
120MP0000681_abnormal_thyroid_gland0.99852581
121MP0008569_lethality_at_weaning0.99606179
122MP0002693_abnormal_pancreas_physiology0.98948253
123MP0000230_abnormal_systemic_arterial0.97704248
124MP0001919_abnormal_reproductive_system0.97511027
125MP0003195_calcinosis0.97178785
126MP0002095_abnormal_skin_pigmentation0.93701167
127MP0004924_abnormal_behavior0.92604841
128MP0005386_behavior/neurological_phenoty0.92604841
129MP0000372_irregular_coat_pigmentation0.92459897
130MP0006082_CNS_inflammation0.92331657
131MP0004043_abnormal_pH_regulation0.92134729
132MP0002882_abnormal_neuron_morphology0.91990126
133MP0004883_abnormal_blood_vessel0.91422663
134MP0004145_abnormal_muscle_electrophysio0.91108302
135MP0003879_abnormal_hair_cell0.91054183
136MP0003868_abnormal_feces_composition0.90919946
137MP0003938_abnormal_ear_development0.90308372
138MP0005085_abnormal_gallbladder_physiolo0.89927219
139MP0002405_respiratory_system_inflammati0.89579222
140MP0003724_increased_susceptibility_to0.89505076
141MP0005084_abnormal_gallbladder_morpholo0.88962970
142MP0000613_abnormal_salivary_gland0.88550544
143MP0002752_abnormal_somatic_nervous0.87422787
144MP0008469_abnormal_protein_level0.85638134
145MP0005394_taste/olfaction_phenotype0.84986973
146MP0005499_abnormal_olfactory_system0.84986973
147MP0004134_abnormal_chest_morphology0.84041664
148MP0005174_abnormal_tail_pigmentation0.82125421
149MP0002722_abnormal_immune_system0.81357026
150MP0000955_abnormal_spinal_cord0.80988158
151MP0002006_tumorigenesis0.80931144
152MP0003638_abnormal_response/metabolism_0.80737810
153MP0001346_abnormal_lacrimal_gland0.80197555
154MP0002066_abnormal_motor_capabilities/c0.79542132
155MP0009333_abnormal_splenocyte_physiolog0.79444085
156MP0002429_abnormal_blood_cell0.77692927
157MP0002751_abnormal_autonomic_nervous0.76094534
158MP0003633_abnormal_nervous_system0.74329671
159MP0001765_abnormal_ion_homeostasis0.71665921
160MP0005310_abnormal_salivary_gland0.69674356
161MP0003122_maternal_imprinting0.68380140
162MP0001177_atelectasis0.68319215
163MP0002132_abnormal_respiratory_system0.67879357
164MP0008789_abnormal_olfactory_epithelium0.65482046

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.45065418
2Retinal dysplasia (HP:0007973)3.96974046
3Pancreatic cysts (HP:0001737)3.91418550
4Renal Fanconi syndrome (HP:0001994)3.72792187
5Molar tooth sign on MRI (HP:0002419)3.57100569
6Abnormality of midbrain morphology (HP:0002418)3.57100569
7Febrile seizures (HP:0002373)3.55358112
8Stomatitis (HP:0010280)3.38447951
9Increased hepatocellular lipid droplets (HP:0006565)3.36092673
10Parakeratosis (HP:0001036)3.04617611
113-Methylglutaconic aciduria (HP:0003535)3.01637917
12IgG deficiency (HP:0004315)2.97795907
13Mitochondrial inheritance (HP:0001427)2.96200363
14Stomach cancer (HP:0012126)2.92797719
15Acute necrotizing encephalopathy (HP:0006965)2.89763450
16Nephronophthisis (HP:0000090)2.89176075
17Abnormality of the renal cortex (HP:0011035)2.88699893
18Elevated erythrocyte sedimentation rate (HP:0003565)2.81910643
19Polydipsia (HP:0001959)2.81510822
20Abnormal drinking behavior (HP:0030082)2.81510822
21Lipid accumulation in hepatocytes (HP:0006561)2.79870456
22Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.74070841
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.73727054
24Hypothermia (HP:0002045)2.70932550
25Abnormality of renal resorption (HP:0011038)2.64482149
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58881994
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.57280076
28Abnormality of the renal medulla (HP:0100957)2.56162862
29Epileptic encephalopathy (HP:0200134)2.55916418
30Attenuation of retinal blood vessels (HP:0007843)2.51227737
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.50349593
32Tubulointerstitial nephritis (HP:0001970)2.49446715
33Progressive cerebellar ataxia (HP:0002073)2.48355371
34Abolished electroretinogram (ERG) (HP:0000550)2.48093196
35Abnormal mitochondria in muscle tissue (HP:0008316)2.46245417
36Abnormal hair whorl (HP:0010721)2.45603606
37Myokymia (HP:0002411)2.44705624
38Type II lissencephaly (HP:0007260)2.43471717
39Medial flaring of the eyebrow (HP:0010747)2.42029478
40Congenital sensorineural hearing impairment (HP:0008527)2.39776347
41Progressive macrocephaly (HP:0004481)2.37222930
42Chronic hepatic failure (HP:0100626)2.36868572
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.34368298
44Abnormality of the prostate (HP:0008775)2.33348723
45Methylmalonic aciduria (HP:0012120)2.33291007
46Progressive inability to walk (HP:0002505)2.31751528
47Inability to walk (HP:0002540)2.31528635
48Polyuria (HP:0000103)2.31467265
49Abnormality of cells of the erythroid lineage (HP:0012130)2.29414870
50Methylmalonic acidemia (HP:0002912)2.29290733
51Retinal atrophy (HP:0001105)2.26688048
52Abnormality of secondary sexual hair (HP:0009888)2.25451260
53Abnormality of the axillary hair (HP:0100134)2.25451260
54Severe visual impairment (HP:0001141)2.24960893
55Exertional dyspnea (HP:0002875)2.24849829
56Hyperventilation (HP:0002883)2.24825737
57Abnormality of T cell number (HP:0011839)2.23879502
58Bile duct proliferation (HP:0001408)2.22385524
59Abnormal biliary tract physiology (HP:0012439)2.22385524
60Abnormal number of erythroid precursors (HP:0012131)2.22032560
61Type I transferrin isoform profile (HP:0003642)2.21994384
62Increased CSF lactate (HP:0002490)2.21416517
63Optic disc pallor (HP:0000543)2.20847253
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.20249787
65Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19703948
66Recurrent cutaneous fungal infections (HP:0011370)2.19695631
67Chronic mucocutaneous candidiasis (HP:0002728)2.19695631
68Abnormality of T cells (HP:0002843)2.17939887
69Focal seizures (HP:0007359)2.16685534
70Optic nerve hypoplasia (HP:0000609)2.15044303
71Hepatocellular necrosis (HP:0001404)2.14840326
72Abnormality of T cell physiology (HP:0011840)2.14715487
73Cystic liver disease (HP:0006706)2.14602326
74Acute encephalopathy (HP:0006846)2.13652959
75Patchy hypopigmentation of hair (HP:0011365)2.13205445
76Decreased circulating renin level (HP:0003351)2.12360266
77Absent/shortened dynein arms (HP:0200106)2.11002121
78Dynein arm defect of respiratory motile cilia (HP:0012255)2.11002121
79Absent speech (HP:0001344)2.09891378
80Metabolic alkalosis (HP:0200114)2.09282932
81Aplasia/Hypoplasia of the lens (HP:0008063)2.09185764
82Abnormality of the renal collecting system (HP:0004742)2.08746781
83Atonic seizures (HP:0010819)2.08598369
84Nasolacrimal duct obstruction (HP:0000579)2.08211388
85Duplicated collecting system (HP:0000081)2.07603713
86Renal cortical cysts (HP:0000803)2.07455330
87Hypomagnesemia (HP:0002917)2.06683359
88Scanning speech (HP:0002168)2.06662750
89Furrowed tongue (HP:0000221)2.05400995
90T lymphocytopenia (HP:0005403)2.04959401
91Abnormality of calcium-phosphate metabolism (HP:0100530)2.03998202
92Increased intramyocellular lipid droplets (HP:0012240)2.03393874
93Abnormality of B cell number (HP:0010975)2.02499111
94Generalized tonic-clonic seizures (HP:0002069)2.02385917
95Abnormality of dental color (HP:0011073)2.01562211
96Tubular atrophy (HP:0000092)2.01276159
97Optic neuritis (HP:0100653)2.01260140
98Retrobulbar optic neuritis (HP:0100654)2.01260140
99Myositis (HP:0100614)2.01090390
100Thyroiditis (HP:0100646)1.98271085
101Submucous cleft hard palate (HP:0000176)1.96994158
102Broad-based gait (HP:0002136)1.96840467
103Recurrent fungal infections (HP:0002841)1.95969226
104Thyroid-stimulating hormone excess (HP:0002925)1.95721737
105White forelock (HP:0002211)1.95332777
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94370272
107Tetany (HP:0001281)1.93668677
108Amelogenesis imperfecta (HP:0000705)1.93000624
109Xerostomia (HP:0000217)1.92442633
110Abnormality of incisor morphology (HP:0011063)1.91969681
111Gait imbalance (HP:0002141)1.91557285
112Decreased central vision (HP:0007663)1.90974127
113Congenital stationary night blindness (HP:0007642)1.90954211
114Congenital primary aphakia (HP:0007707)1.90890287
115Abnormal rod and cone electroretinograms (HP:0008323)1.90467952
116Reticulocytopenia (HP:0001896)1.89443779
117Congenital, generalized hypertrichosis (HP:0004540)1.86013194
118Nephrogenic diabetes insipidus (HP:0009806)1.85812978
119Renal tubular dysfunction (HP:0000124)1.85784703
120Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85674375
121Abnormal protein glycosylation (HP:0012346)1.85261789
122Abnormal glycosylation (HP:0012345)1.85261789
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85261789
124Abnormal protein N-linked glycosylation (HP:0012347)1.85261789
125Abnormality of eosinophils (HP:0001879)1.84840255
126Chromsome breakage (HP:0040012)1.84673934
127Corneal dystrophy (HP:0001131)1.84460416
128Global brain atrophy (HP:0002283)1.83809552
129Abnormal urine output (HP:0012590)1.82049007
130Symptomatic seizures (HP:0011145)1.81517558
131Hepatic necrosis (HP:0002605)1.81497025
132Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81443149
133Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81443149
134Degeneration of the lateral corticospinal tracts (HP:0002314)1.81032094
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81032094
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.80683728
137Hypoproteinemia (HP:0003075)1.80547986
138True hermaphroditism (HP:0010459)1.80225221
139Encephalitis (HP:0002383)1.80022215
140Ketoacidosis (HP:0001993)1.79690418
141Increased circulating renin level (HP:0000848)1.78964290
142Renal dysplasia (HP:0000110)1.78500602
143Panhypogammaglobulinemia (HP:0003139)1.77344914
144Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77310227
145Ketosis (HP:0001946)1.76648432
146Male pseudohermaphroditism (HP:0000037)1.76629296
147Increased corneal curvature (HP:0100692)1.74907737
148Keratoconus (HP:0000563)1.74907737
149Aplasia/Hypoplasia of the spleen (HP:0010451)1.74478653
150Abnormal respiratory motile cilium morphology (HP:0005938)1.74239274
151Abnormal respiratory epithelium morphology (HP:0012253)1.74239274
152Aplasia/hypoplasia of the uterus (HP:0008684)1.74195010
153Sclerocornea (HP:0000647)1.73361350
154Genital tract atresia (HP:0001827)1.73183765
155Gaze-evoked nystagmus (HP:0000640)1.73102376
156Pancreatic fibrosis (HP:0100732)1.73044137
157Recurrent bacterial skin infections (HP:0005406)1.73029222
158Aplastic anemia (HP:0001915)1.72133773
159Congenital hepatic fibrosis (HP:0002612)1.71819315
160Microvesicular hepatic steatosis (HP:0001414)1.71162999
161Alveolar cell carcinoma (HP:0006519)1.70565887
162Aplasia cutis congenita (HP:0001057)1.70445851
163Constricted visual fields (HP:0001133)1.69830613
164Protruding tongue (HP:0010808)1.69517918
165Eosinophilia (HP:0001880)1.69046605
166Dialeptic seizures (HP:0011146)1.68900364
167Orchitis (HP:0100796)1.68677555
168Abnormal ciliary motility (HP:0012262)1.68596569
169Asplenia (HP:0001746)1.67946027
170Respiratory difficulties (HP:0002880)1.67478104
171Hypophosphatemic rickets (HP:0004912)1.67368202
172Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66984521
173Abnormality of alanine metabolism (HP:0010916)1.66984521
174Hyperalaninemia (HP:0003348)1.66984521
175Abnormality of macular pigmentation (HP:0008002)1.66558497
176Large for gestational age (HP:0001520)1.66130138
177Obstructive lung disease (HP:0006536)1.66046993
178Chronic obstructive pulmonary disease (HP:0006510)1.66046993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.11371573
2CASK3.89137162
3TNIK3.54692034
4TAOK33.09077888
5MAP2K73.05451589
6MAP3K122.75684685
7NTRK32.64604591
8PRPF4B2.64307157
9INSRR2.52780776
10PNCK2.43468550
11NUAK12.43351333
12MAP4K21.97276621
13TLK11.90280837
14MAP4K11.81143981
15TXK1.79866573
16EPHA41.73452307
17STK161.69865378
18BMPR1B1.66611288
19OXSR11.63616307
20FES1.60056595
21MST41.58829156
22BRD41.57259274
23GRK61.53479019
24RIPK41.52863695
25TRIM281.52762750
26GRK51.51947272
27GRK71.48300691
28PKN11.47323369
29BMPR21.44282475
30TNK21.43391139
31ITK1.42155626
32STK391.42000029
33MUSK1.41521669
34ARAF1.41507457
35IKBKB1.37862688
36MAPK131.31796195
37ERBB31.29458047
38CDK191.27665240
39KIT1.27545602
40TEC1.27080227
41GRK11.22590055
42IRAK41.17737112
43ADRBK21.16198499
44BCR1.15727336
45ACVR1B1.14648351
46CAMK11.13970795
47MAP2K61.13887114
48CSNK1A1L1.10340844
49CSNK1G31.06643642
50MAP3K131.05383460
51IKBKE1.04086237
52YES11.02479217
53MAPKAPK51.01306493
54VRK11.00290128
55SIK30.96737850
56CSNK1G10.96560895
57AKT30.94041404
58CSF1R0.93929327
59BCKDK0.93108627
60BLK0.92172263
61IRAK20.91131583
62NME10.89978542
63PIK3CG0.89948075
64PRKCE0.89926179
65CDK30.89515327
66CAMKK20.89452978
67MKNK20.86678208
68DAPK20.86595024
69CSNK1G20.86460518
70CAMK2B0.86343946
71PINK10.85784846
72LCK0.83033065
73CAMK2D0.81549157
74MAPKAPK30.81215014
75MAPK150.81099944
76CAMK2A0.81077591
77MARK10.81008566
78ZAK0.80775008
79PTK2B0.78433851
80PIK3CA0.78174179
81DYRK1A0.77321719
82WNK30.77146393
83ZAP700.76156300
84PLK20.75005842
85CSK0.74827166
86MAP3K40.74118310
87PAK30.72929000
88NTRK20.72911005
89PIM10.71851272
90IRAK10.69696913
91JAK30.65652442
92CAMK2G0.63865139
93WNK40.63782329
94PBK0.61904887
95IRAK30.61878917
96CAMK1G0.61675776
97SYK0.59529482
98SRPK10.58924740
99PRKCQ0.58656475
100NEK60.57551069
101MATK0.57304757
102MYLK0.56287909
103HCK0.54344250
104PRKG10.54046554
105SGK4940.53377112
106SGK2230.53377112
107SIK20.53274765
108BRAF0.52798537
109RPS6KA50.52380801
110PIM20.52195332
111CDK50.51730160
112PRKCG0.50891393
113NME20.49964293
114NLK0.49926414
115PRKACA0.49844341
116JAK20.48908567
117DYRK20.48667506
118MINK10.46821783
119CSNK1A10.46789850
120LYN0.46280505
121MARK30.46194964
122SGK20.45848157
123VRK20.44577615
124TIE10.44509728
125ADRBK10.44368525
126CLK10.41880814
127HIPK20.41702237
128WNK10.41380567
129MAP2K20.41229038
130FGFR20.39309506
131TYK20.39198086
132MAP3K140.38917100
133TRPM70.38773747
134UHMK10.38251939
135ABL10.37872474
136CHUK0.37528179
137IGF1R0.36648506
138PRKD20.36628570
139PRKCA0.36545538
140MAP3K10.36105470
141BTK0.36055793
142CCNB10.35852249
143DAPK10.35754990
144MAP2K40.35512616
145KDR0.35500602
146RPS6KA60.30092082
147EIF2AK30.29615436

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.37149429
2Nicotine addiction_Homo sapiens_hsa050333.27982778
3Protein export_Homo sapiens_hsa030603.21034821
4Phototransduction_Homo sapiens_hsa047442.70255688
5* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47043527
6Parkinsons disease_Homo sapiens_hsa050122.33193490
7Alzheimers disease_Homo sapiens_hsa050102.29997899
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12958938
9Taste transduction_Homo sapiens_hsa047421.97338609
10Glutamatergic synapse_Homo sapiens_hsa047241.97047405
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94793073
12Ribosome_Homo sapiens_hsa030101.93159862
13SNARE interactions in vesicular transport_Homo sapiens_hsa041301.93020055
14Serotonergic synapse_Homo sapiens_hsa047261.90671137
15Collecting duct acid secretion_Homo sapiens_hsa049661.78392008
16Circadian entrainment_Homo sapiens_hsa047131.76632435
17GABAergic synapse_Homo sapiens_hsa047271.76113545
18Nitrogen metabolism_Homo sapiens_hsa009101.72903942
19Morphine addiction_Homo sapiens_hsa050321.72887086
20Sulfur metabolism_Homo sapiens_hsa009201.69002171
21Huntingtons disease_Homo sapiens_hsa050161.67987327
22Sphingolipid metabolism_Homo sapiens_hsa006001.62540538
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59052348
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.58005776
25Ether lipid metabolism_Homo sapiens_hsa005651.56836171
26Amphetamine addiction_Homo sapiens_hsa050311.56318257
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54081762
28Insulin secretion_Homo sapiens_hsa049111.50379734
29Olfactory transduction_Homo sapiens_hsa047401.46158807
30Vitamin digestion and absorption_Homo sapiens_hsa049771.44003300
31Arachidonic acid metabolism_Homo sapiens_hsa005901.43080967
32Long-term depression_Homo sapiens_hsa047301.42292195
33Salivary secretion_Homo sapiens_hsa049701.36785930
34Antigen processing and presentation_Homo sapiens_hsa046121.35537772
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34232477
36Synaptic vesicle cycle_Homo sapiens_hsa047211.33653342
37Staphylococcus aureus infection_Homo sapiens_hsa051501.30954083
38Long-term potentiation_Homo sapiens_hsa047201.29604124
39Caffeine metabolism_Homo sapiens_hsa002321.26507203
40RNA polymerase_Homo sapiens_hsa030201.25678217
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25582628
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.24930369
43Proteasome_Homo sapiens_hsa030501.24604120
44Pancreatic secretion_Homo sapiens_hsa049721.23940709
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.23755846
46Linoleic acid metabolism_Homo sapiens_hsa005911.23713032
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22643146
48Butanoate metabolism_Homo sapiens_hsa006501.21468415
49Renin secretion_Homo sapiens_hsa049241.19701257
50RNA degradation_Homo sapiens_hsa030181.15564191
51Calcium signaling pathway_Homo sapiens_hsa040201.15563605
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14634177
53Dopaminergic synapse_Homo sapiens_hsa047281.11789398
54Cardiac muscle contraction_Homo sapiens_hsa042601.11468426
55Other glycan degradation_Homo sapiens_hsa005111.09212191
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.08383047
57Vibrio cholerae infection_Homo sapiens_hsa051101.08022714
58Cocaine addiction_Homo sapiens_hsa050301.07610344
59Chemical carcinogenesis_Homo sapiens_hsa052041.06827596
60Tryptophan metabolism_Homo sapiens_hsa003801.06449266
61Leishmaniasis_Homo sapiens_hsa051401.05818659
62Rheumatoid arthritis_Homo sapiens_hsa053231.05580148
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04932716
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01086978
65Peroxisome_Homo sapiens_hsa041461.01044214
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00431099
67Histidine metabolism_Homo sapiens_hsa003400.98794795
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97151864
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96608034
70Fatty acid elongation_Homo sapiens_hsa000620.96444720
71Cholinergic synapse_Homo sapiens_hsa047250.92070355
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91169907
73Autoimmune thyroid disease_Homo sapiens_hsa053200.91108319
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90753531
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90567182
76Selenocompound metabolism_Homo sapiens_hsa004500.85322281
77Propanoate metabolism_Homo sapiens_hsa006400.84506875
78Gastric acid secretion_Homo sapiens_hsa049710.82481630
79T cell receptor signaling pathway_Homo sapiens_hsa046600.81580368
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79744934
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79189478
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72255450
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.72012648
84Retinol metabolism_Homo sapiens_hsa008300.70901431
85cAMP signaling pathway_Homo sapiens_hsa040240.70596953
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70377904
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69973467
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69850075
89One carbon pool by folate_Homo sapiens_hsa006700.69234627
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69102312
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67454626
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.66562139
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65054550
94Regulation of autophagy_Homo sapiens_hsa041400.64981692
95Tuberculosis_Homo sapiens_hsa051520.63280137
96Purine metabolism_Homo sapiens_hsa002300.63105821
97Asthma_Homo sapiens_hsa053100.61029038
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.60799929
99Herpes simplex infection_Homo sapiens_hsa051680.60354832
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60259851
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.59864692
102Steroid biosynthesis_Homo sapiens_hsa001000.56608266
103Allograft rejection_Homo sapiens_hsa053300.56445180
104Fanconi anemia pathway_Homo sapiens_hsa034600.55121090
105Glycerolipid metabolism_Homo sapiens_hsa005610.54465129
106ABC transporters_Homo sapiens_hsa020100.54352918
107Measles_Homo sapiens_hsa051620.53670532
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.51090258
109Oxytocin signaling pathway_Homo sapiens_hsa049210.50977224
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50535718
111Axon guidance_Homo sapiens_hsa043600.50463341
112Ovarian steroidogenesis_Homo sapiens_hsa049130.49327429
113Type I diabetes mellitus_Homo sapiens_hsa049400.49216916
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48627948
115Basal transcription factors_Homo sapiens_hsa030220.47003592
116Hematopoietic cell lineage_Homo sapiens_hsa046400.46456306
117Melanogenesis_Homo sapiens_hsa049160.46045690
118Osteoclast differentiation_Homo sapiens_hsa043800.46005573
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45094200
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44584362
121Systemic lupus erythematosus_Homo sapiens_hsa053220.43726342
122TNF signaling pathway_Homo sapiens_hsa046680.42827384
123Toxoplasmosis_Homo sapiens_hsa051450.42452656
124* Metabolic pathways_Homo sapiens_hsa011000.42133045
125Viral myocarditis_Homo sapiens_hsa054160.41023418
126Homologous recombination_Homo sapiens_hsa034400.39172526
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38041630
128Platelet activation_Homo sapiens_hsa046110.37903284
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.37042913
130Ras signaling pathway_Homo sapiens_hsa040140.36112723
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36085401
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36036880
133GnRH signaling pathway_Homo sapiens_hsa049120.35026931
134Fatty acid degradation_Homo sapiens_hsa000710.34368131
135Pyrimidine metabolism_Homo sapiens_hsa002400.34249108
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33878408
137Primary immunodeficiency_Homo sapiens_hsa053400.32746677
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32617707
139Phagosome_Homo sapiens_hsa041450.32172411
140African trypanosomiasis_Homo sapiens_hsa051430.31284630
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30801083
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30280909
143Graft-versus-host disease_Homo sapiens_hsa053320.29982935

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