ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to lipoprotein particle (GO:0055094)	6.79507251
2	pyrimidine nucleobase catabolic process (GO:0006208)	5.32718922
3	positive regulation of cell size (GO:0045793)	4.62627245
4	negative regulation of neurotransmitter transport (GO:0051589)	4.51482064
5	nucleobase catabolic process (GO:0046113)	4.45381153
6	regulation of synaptic vesicle exocytosis (GO:2000300)	3.93589970
7	microtubule nucleation (GO:0007020)	3.89962739
8	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.77944451
9	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.74611197
10	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.74385170
11	axonal fasciculation (GO:0007413)	3.72508776
12	positive regulation of catecholamine secretion (GO:0033605)	3.72503280
13	regulation of synaptic vesicle transport (GO:1902803)	3.64550506
14	nerve growth factor signaling pathway (GO:0038180)	3.62779293
15	regulation of plasminogen activation (GO:0010755)	3.52421146
16	glutamate secretion (GO:0014047)	3.48628268
17	cellular protein complex localization (GO:0034629)	3.46510752
18	protein localization to synapse (GO:0035418)	3.42872109
19	presynaptic membrane assembly (GO:0097105)	3.40934654
20	cell wall macromolecule metabolic process (GO:0044036)	3.33394598
21	presynaptic membrane organization (GO:0097090)	3.32050563
22	synaptic vesicle maturation (GO:0016188)	3.31934941
23	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.25399077
24	layer formation in cerebral cortex (GO:0021819)	3.25329486
25	neuron recognition (GO:0008038)	3.24530027
26	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	3.21898622
27	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.20175417
28	postsynaptic membrane organization (GO:0001941)	3.07328289
29	behavioral defense response (GO:0002209)	3.01850590
30	behavioral fear response (GO:0001662)	3.01850590
31	skeletal muscle organ development (GO:0060538)	3.00594597
32	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.00284104
33	negative regulation of neurotransmitter secretion (GO:0046929)	2.99993364
34	cartilage morphogenesis (GO:0060536)	2.99376761
35	negative regulation of keratinocyte proliferation (GO:0010839)	2.97143711
36	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.96437640
37	synaptic vesicle exocytosis (GO:0016079)	2.96412413
38	positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)	2.88810087
39	establishment of mitochondrion localization (GO:0051654)	2.87099733
40	neurotransmitter-gated ion channel clustering (GO:0072578)	2.81653326
41	cell wall macromolecule catabolic process (GO:0016998)	2.80072726
42	innervation (GO:0060384)	2.79527525
43	response to hepatocyte growth factor (GO:0035728)	2.79070310
44	cellular response to hepatocyte growth factor stimulus (GO:0035729)	2.79070310
45	epithelial cell differentiation involved in kidney development (GO:0035850)	2.78106762
46	negative regulation of cell size (GO:0045792)	2.76011778
47	regulation of glutamate receptor signaling pathway (GO:1900449)	2.75784462
48	negative regulation of axon guidance (GO:1902668)	2.75730417
49	organelle transport along microtubule (GO:0072384)	2.74845947
50	dendritic spine morphogenesis (GO:0060997)	2.73328195
51	homocysteine metabolic process (GO:0050667)	2.72340056
52	neurotransmitter secretion (GO:0007269)	2.71777050
53	regulation of axon guidance (GO:1902667)	2.71526523
54	histone H3-K4 methylation (GO:0051568)	2.71395155
55	peptidyl-cysteine modification (GO:0018198)	2.69986691
56	protein targeting to lysosome (GO:0006622)	2.68519437
57	establishment of protein localization to vacuole (GO:0072666)	2.68519437
58	protein targeting to vacuole (GO:0006623)	2.68519437
59	positive regulation of endothelial cell differentiation (GO:0045603)	2.67482096
60	diaphragm development (GO:0060539)	2.62789811
61	positive regulation of dendritic spine development (GO:0060999)	2.62189501
62	regulation of oligodendrocyte differentiation (GO:0048713)	2.62147081
63	glial cell proliferation (GO:0014009)	2.60240748
64	long-term synaptic potentiation (GO:0060291)	2.59760162
65	central nervous system projection neuron axonogenesis (GO:0021952)	2.59209260
66	endoplasmic reticulum organization (GO:0007029)	2.58283094
67	desmosome organization (GO:0002934)	2.55856046
68	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.55604135
69	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	2.54880528
70	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.52466765
71	response to parathyroid hormone (GO:0071107)	2.52189565
72	axon extension involved in axon guidance (GO:0048846)	2.51876771
73	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.51876771
74	positive regulation of macroautophagy (GO:0016239)	2.50835985
75	vocalization behavior (GO:0071625)	2.49078388
76	gamma-aminobutyric acid transport (GO:0015812)	2.48813514
77	regulation of neuronal synaptic plasticity (GO:0048168)	2.48364842
78	phosphorelay signal transduction system (GO:0000160)	2.47511150
79	regulation of intracellular estrogen receptor signaling pathway (GO:0033146)	2.47051347
80	cellular response to vitamin D (GO:0071305)	2.46122855
81	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.45126765
82	negative regulation of vascular permeability (GO:0043116)	2.44885405
83	regulation of glycogen (starch) synthase activity (GO:2000465)	2.44648599
84	protein import into peroxisome matrix (GO:0016558)	2.44604758
85	negative regulation of microtubule polymerization (GO:0031115)	2.44572286
86	fear response (GO:0042596)	2.44398279
87	central nervous system neuron axonogenesis (GO:0021955)	2.44390726
88	response to nerve growth factor (GO:1990089)	2.42768626
89	cellular response to nerve growth factor stimulus (GO:1990090)	2.42768626
90	regulation of synapse assembly (GO:0051963)	2.41110322
91	synaptic vesicle transport (GO:0048489)	2.39539706
92	establishment of synaptic vesicle localization (GO:0097480)	2.39539706
93	regulation of feeding behavior (GO:0060259)	2.39025791
94	neuron cell-cell adhesion (GO:0007158)	2.39002716
95	positive regulation of dendrite morphogenesis (GO:0050775)	2.38132147
96	positive regulation of fibroblast migration (GO:0010763)	2.37885023
97	establishment of protein localization to Golgi (GO:0072600)	2.35623999
98	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.35546131
99	spermatid nucleus differentiation (GO:0007289)	2.35408635
100	vesicle docking involved in exocytosis (GO:0006904)	2.35295832

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.73853713
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.66459038
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.34760664
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.14779415
5	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.61019109
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.58259921
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.57182886
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.37959963
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.32668357
10	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	2.32541641
11	WT1_19549856_ChIP-ChIP_CCG9911_Human	2.29360086
12	FUS_26573619_Chip-Seq_HEK293_Human	2.26886411
13	REST_21632747_ChIP-Seq_MESCs_Mouse	2.24974385
14	AR_21572438_ChIP-Seq_LNCaP_Human	2.21636438
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.17470416
16	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.16927416
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.03675201
18	TP53_16413492_ChIP-PET_HCT116_Human	1.95639969
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.94990159
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.93378610
21	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.86057505
22	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.85587640
23	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.85148238
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.81886262
25	STAT3_23295773_ChIP-Seq_U87_Human	1.80519293
26	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.79955430
27	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.71224720
28	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.68678548
29	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.68042954
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.66878454
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66607726
32	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.66599812
33	ZNF274_21170338_ChIP-Seq_K562_Hela	1.61503342
34	AHR_22903824_ChIP-Seq_MCF-7_Human	1.61107887
35	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.57844083
36	P300_19829295_ChIP-Seq_ESCs_Human	1.57256613
37	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.54300522
38	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53754690
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.52217135
40	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.49197718
41	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.48127644
42	TCF4_23295773_ChIP-Seq_U87_Human	1.46983060
43	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.45363290
44	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.44080851
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.42944327
46	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.39034948
47	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35188642
48	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.34887017
49	TP53_18474530_ChIP-ChIP_U2OS_Human	1.33038699
50	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.30250351
51	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.29414909
52	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.28417736
53	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.27078176
54	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.24428293
55	SOX9_26525672_Chip-Seq_HEART_Mouse	1.22604015
56	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22455737
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22103768
58	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.20666549
59	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.19532786
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.19200556
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.19200556
62	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.19172519
63	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18867432
64	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.18309002
65	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17984883
66	AR_19668381_ChIP-Seq_PC3_Human	1.14109119
67	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.13451148
68	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12885815
69	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.11906637
70	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10903885
71	JUN_21703547_ChIP-Seq_K562_Human	1.10612049
72	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.09120149
73	AR_25329375_ChIP-Seq_VCAP_Human	1.08811119
74	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.08010751
75	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.08010751
76	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.07934912
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06901263
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.06821443
79	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.06433101
80	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.05562135
81	KDM2B_26808549_Chip-Seq_REH_Human	1.05492285
82	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.04786683
83	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.04568282
84	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.04177591
85	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.04095302
86	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.03806139
87	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.03424724
88	DROSHA_22980978_ChIP-Seq_HELA_Human	1.01839908
89	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01741029
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01547461
91	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01388891
92	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.01316490
93	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.00645337
94	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	1.00244737
95	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.99847193
96	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.99323237
97	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.97984177
98	BRD4_25478319_ChIP-Seq_HGPS_Human	0.97358134
99	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.97055761
100	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.96566193

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005645_abnormal_hypothalamus_physiol	4.29330689
2	MP0004859_abnormal_synaptic_plasticity	3.68848779
3	MP0003787_abnormal_imprinting	3.21284384
4	MP0003880_abnormal_central_pattern	2.90274233
5	MP0004270_analgesia	2.88341304
6	MP0003195_calcinosis	2.86578520
7	MP0005646_abnormal_pituitary_gland	2.70823460
8	MP0002234_abnormal_pharynx_morphology	2.48858085
9	MP0003635_abnormal_synaptic_transmissio	2.39688555
10	MP0000778_abnormal_nervous_system	2.26872823
11	MP0000013_abnormal_adipose_tissue	2.20324074
12	MP0004043_abnormal_pH_regulation	2.04867283
13	MP0002063_abnormal_learning/memory/cond	2.03661766
14	MP0008877_abnormal_DNA_methylation	2.03192072
15	MP0003123_paternal_imprinting	1.99259968
16	MP0001501_abnormal_sleep_pattern	1.96697989
17	MP0004811_abnormal_neuron_physiology	1.90860887
18	MP0009046_muscle_twitch	1.90667398
19	MP0000516_abnormal_urinary_system	1.90184288
20	MP0005367_renal/urinary_system_phenotyp	1.90184288
21	MP0005423_abnormal_somatic_nervous	1.77834335
22	MP0002734_abnormal_mechanical_nocicepti	1.76696515
23	MP0001188_hyperpigmentation	1.75829535
24	MP0002184_abnormal_innervation	1.74906712
25	MP0002572_abnormal_emotion/affect_behav	1.73055767
26	MP0004233_abnormal_muscle_weight	1.71587284
27	MP0000569_abnormal_digit_pigmentation	1.69998978
28	MP0004858_abnormal_nervous_system	1.68368109
29	MP0002272_abnormal_nervous_system	1.67382919
30	MP0002396_abnormal_hematopoietic_system	1.66565362
31	MP0009745_abnormal_behavioral_response	1.66249403
32	MP0002064_seizures	1.62229042
33	MP0000631_abnormal_neuroendocrine_gland	1.61914586
34	MP0005167_abnormal_blood-brain_barrier	1.59847447
35	MP0000955_abnormal_spinal_cord	1.58611081
36	MP0006276_abnormal_autonomic_nervous	1.56231142
37	MP0001661_extended_life_span	1.53703031
38	MP0003705_abnormal_hypodermis_morpholog	1.53664948
39	MP0003890_abnormal_embryonic-extraembry	1.53362215
40	MP0005623_abnormal_meninges_morphology	1.45053060
41	MP0003045_fibrosis	1.39140800
42	MP0003122_maternal_imprinting	1.38052766
43	MP0008438_abnormal_cutaneous_collagen	1.35732675
44	MP0004147_increased_porphyrin_level	1.35025932
45	MP0000566_synostosis	1.32741573
46	MP0003121_genomic_imprinting	1.31400791
47	MP0001968_abnormal_touch/_nociception	1.31368128
48	MP0004885_abnormal_endolymph	1.30499246
49	MP0010368_abnormal_lymphatic_system	1.30008698
50	MP0005076_abnormal_cell_differentiation	1.29841517
51	MP0002736_abnormal_nociception_after	1.28584102
52	MP0001440_abnormal_grooming_behavior	1.26986163
53	MP0003183_abnormal_peptide_metabolism	1.25115987
54	MP0001486_abnormal_startle_reflex	1.24144953
55	MP0002882_abnormal_neuron_morphology	1.23155950
56	MP0001984_abnormal_olfaction	1.23044203
57	MP0005451_abnormal_body_composition	1.18515191
58	MP0005409_darkened_coat_color	1.18040113
59	MP0001970_abnormal_pain_threshold	1.17107605
60	MP0002735_abnormal_chemical_nociception	1.13339104
61	MP0005187_abnormal_penis_morphology	1.11854324
62	MP0002067_abnormal_sensory_capabilities	1.08364254
63	MP0003633_abnormal_nervous_system	1.06403205
64	MP0002152_abnormal_brain_morphology	1.05874309
65	MP0002751_abnormal_autonomic_nervous	1.05070241
66	MP0001270_distended_abdomen	1.04477470
67	MP0005275_abnormal_skin_tensile	1.03756596
68	MP0003879_abnormal_hair_cell	1.01299209
69	MP0002069_abnormal_eating/drinking_beha	0.93221610
70	MP0002295_abnormal_pulmonary_circulatio	0.92901634
71	MP0002752_abnormal_somatic_nervous	0.92496841
72	MP0003631_nervous_system_phenotype	0.90801489
73	MP0010352_gastrointestinal_tract_polyps	0.90341886
74	MP0002557_abnormal_social/conspecific_i	0.87774156
75	MP0005551_abnormal_eye_electrophysiolog	0.87335329
76	MP0001919_abnormal_reproductive_system	0.87078263
77	MP0002066_abnormal_motor_capabilities/c	0.86580361
78	MP0003172_abnormal_lysosome_physiology	0.85643705
79	MP0003385_abnormal_body_wall	0.83382389
80	MP0003937_abnormal_limbs/digits/tail_de	0.83054515
81	MP0003861_abnormal_nervous_system	0.81150372
82	MP0000003_abnormal_adipose_tissue	0.80931521
83	MP0000534_abnormal_ureter_morphology	0.80833298
84	MP0008569_lethality_at_weaning	0.78343529
85	MP0002733_abnormal_thermal_nociception	0.77353416
86	MP0003935_abnormal_craniofacial_develop	0.77330039
87	MP0003646_muscle_fatigue	0.75505316
88	MP0000647_abnormal_sebaceous_gland	0.75223186
89	MP0002009_preneoplasia	0.74819384
90	MP0002896_abnormal_bone_mineralization	0.71786472
91	MP0002081_perinatal_lethality	0.69615971
92	MP0001286_abnormal_eye_development	0.69325505
93	MP0001502_abnormal_circadian_rhythm	0.69086251
94	MP0002168_other_aberrant_phenotype	0.68694700
95	MP0001915_intracranial_hemorrhage	0.67894518
96	MP0008995_early_reproductive_senescence	0.67095607
97	MP0002928_abnormal_bile_duct	0.66340054
98	MP0010234_abnormal_vibrissa_follicle	0.65898776
99	MP0002229_neurodegeneration	0.65241355
100	MP0004130_abnormal_muscle_cell	0.65031852

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Sparse lateral eyebrow (HP:0005338)	3.56297533
2	Action tremor (HP:0002345)	3.36638646
3	Fatigue (HP:0012378)	3.35862555
4	Focal seizures (HP:0007359)	3.16813275
5	Focal motor seizures (HP:0011153)	3.14215728
6	Epileptic encephalopathy (HP:0200134)	3.12005425
7	Abnormality of alanine metabolism (HP:0010916)	2.91868236
8	Hyperalaninemia (HP:0003348)	2.91868236
9	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.91868236
10	Febrile seizures (HP:0002373)	2.90492370
11	Cortical dysplasia (HP:0002539)	2.85016558
12	Atonic seizures (HP:0010819)	2.83022792
13	Urinary urgency (HP:0000012)	2.81607407
14	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.77502992
15	Neoplasm of the adrenal cortex (HP:0100641)	2.72963059
16	Hepatoblastoma (HP:0002884)	2.61703773
17	Heterochromia iridis (HP:0001100)	2.58323989
18	Drooling (HP:0002307)	2.52752053
19	Asymmetry of the thorax (HP:0001555)	2.51473096
20	Abnormality of the fingertips (HP:0001211)	2.46453026
21	Medulloblastoma (HP:0002885)	2.41937281
22	Papilledema (HP:0001085)	2.39753055
23	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.37377238
24	Constricted visual fields (HP:0001133)	2.28136909
25	Excessive salivation (HP:0003781)	2.27197046
26	Spastic gait (HP:0002064)	2.24028140
27	Increased density of long bones (HP:0006392)	2.23921974
28	Absent eyebrow (HP:0002223)	2.18324368
29	Autoamputation (HP:0001218)	2.17550013
30	Ureteral obstruction (HP:0006000)	2.16981684
31	Anal stenosis (HP:0002025)	2.16964607
32	Ectopic kidney (HP:0000086)	2.16859720
33	Ureteral stenosis (HP:0000071)	2.15816532
34	Intention tremor (HP:0002080)	2.15694515
35	Ankle clonus (HP:0011448)	2.13933478
36	Abnormality of the astrocytes (HP:0100707)	2.12781033
37	Astrocytoma (HP:0009592)	2.12781033
38	Generalized myoclonic seizures (HP:0002123)	2.12671790
39	Overgrowth (HP:0001548)	2.06152555
40	Truncal ataxia (HP:0002078)	2.06000782
41	Long palpebral fissure (HP:0000637)	2.05577388
42	Transitional cell carcinoma of the bladder (HP:0006740)	2.03532932
43	Concave nail (HP:0001598)	2.02282814
44	Bladder neoplasm (HP:0009725)	2.01334864
45	Bladder carcinoma (HP:0002862)	2.01334864
46	Agitation (HP:0000713)	1.99015846
47	Termporal pattern (HP:0011008)	1.97792540
48	Insidious onset (HP:0003587)	1.97792540
49	Amblyopia (HP:0000646)	1.97702063
50	Hemiparesis (HP:0001269)	1.96811355
51	Complete atrioventricular canal defect (HP:0001674)	1.96382903
52	Glioma (HP:0009733)	1.96256472
53	Broad ribs (HP:0000885)	1.95416062
54	Mild short stature (HP:0003502)	1.95184919
55	Cubitus valgus (HP:0002967)	1.94326931
56	Dialeptic seizures (HP:0011146)	1.93899473
57	Generalized tonic-clonic seizures (HP:0002069)	1.93861409
58	Abnormality of the periventricular white matter (HP:0002518)	1.93834892
59	Abnormality of the lower motor neuron (HP:0002366)	1.91041562
60	Tubulointerstitial nephritis (HP:0001970)	1.89221482
61	Absent speech (HP:0001344)	1.87249485
62	Pheochromocytoma (HP:0002666)	1.85844489
63	Absence seizures (HP:0002121)	1.84035188
64	Impaired vibration sensation in the lower limbs (HP:0002166)	1.82996021
65	Wide intermamillary distance (HP:0006610)	1.81898829
66	Short 5th finger (HP:0009237)	1.81657533
67	Keratoconus (HP:0000563)	1.80939581
68	Increased corneal curvature (HP:0100692)	1.80939581
69	Status epilepticus (HP:0002133)	1.79440222
70	Lower limb hyperreflexia (HP:0002395)	1.79181142
71	Ectropion (HP:0000656)	1.78356721
72	Hypoplastic nipples (HP:0002557)	1.78062672
73	Reduced subcutaneous adipose tissue (HP:0003758)	1.77242294
74	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	1.75449134
75	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.75287959
76	Anhidrosis (HP:0000970)	1.74811651
77	Epileptiform EEG discharges (HP:0011182)	1.74456443
78	Increased circulating renin level (HP:0000848)	1.74353334
79	Depression (HP:0000716)	1.73673097
80	Visceral angiomatosis (HP:0100761)	1.73419441
81	Neoplasm of the heart (HP:0100544)	1.72553243
82	EEG with generalized epileptiform discharges (HP:0011198)	1.71652312
83	Ependymoma (HP:0002888)	1.71080061
84	Hammertoe (HP:0001765)	1.67925939
85	Progressive cerebellar ataxia (HP:0002073)	1.66353512
86	Lower limb muscle weakness (HP:0007340)	1.65863891
87	Malignant neoplasm of the central nervous system (HP:0100836)	1.64741332
88	Hypsarrhythmia (HP:0002521)	1.63214721
89	Orthostatic hypotension (HP:0001278)	1.62973238
90	Myokymia (HP:0002411)	1.62781345
91	Clonus (HP:0002169)	1.62559588
92	Depressed nasal tip (HP:0000437)	1.62365944
93	Delayed CNS myelination (HP:0002188)	1.60940473
94	Atrioventricular canal defect (HP:0006695)	1.60681018
95	Short chin (HP:0000331)	1.60302066
96	Unsteady gait (HP:0002317)	1.60134345
97	Failure to thrive in infancy (HP:0001531)	1.59436626
98	Delusions (HP:0000746)	1.58913732
99	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.58345937
100	Hemangiomatosis (HP:0007461)	1.57451466

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	4.43643736
2	MARK1	3.21283802
3	NTRK2	3.04114818
4	CCNB1	2.84946900
5	MAP3K4	2.83809323
6	EPHA3	2.65911586
7	MAP2K7	2.55874832
8	STK24	2.48631362
9	BCKDK	2.13330664
10	EPHA4	2.08253696
11	TESK2	1.95798397
12	NTRK3	1.94467289
13	PLK2	1.92539674
14	JAK3	1.71392010
15	FRK	1.64957222
16	CAMK1G	1.64564003
17	TAOK3	1.60395438
18	MAPK13	1.55957515
19	WNK1	1.55866795
20	SRPK1	1.54588852
21	SGK2	1.50356875
22	ERBB3	1.48084440
23	MINK1	1.46592282
24	SGK494	1.46585997
25	SGK223	1.46585997
26	DAPK2	1.40951633
27	CAMKK2	1.39756011
28	MAP3K2	1.39737205
29	CAMK1D	1.38489558
30	MAP3K3	1.37035564
31	ZAK	1.31225229
32	PAK6	1.30880702
33	NTRK1	1.29467018
34	SGK3	1.28836988
35	WNK4	1.28460739
36	CSNK1A1L	1.12354247
37	PAK3	1.11681607
38	AKT3	1.11651840
39	CAMK1	1.10795602
40	CAMK4	1.10176730
41	BCR	1.09313777
42	TRIM28	1.09288023
43	PINK1	1.08860869
44	CDK9	1.06267612
45	CLK1	1.02885293
46	MAP4K2	1.02868807
47	FLT3	1.01143839
48	EIF2AK3	0.97499674
49	DYRK3	0.97488218
50	UHMK1	0.96447448
51	CSNK1G3	0.93519893
52	SCYL2	0.92087368
53	DYRK2	0.91589039
54	BRD4	0.81725947
55	CSNK1G2	0.80807996
56	STK39	0.78162583
57	FGR	0.77878403
58	SIK2	0.77669331
59	MAP3K6	0.77641806
60	PRKCG	0.77212771
61	CDK5	0.76737566
62	PRKD3	0.76655098
63	DAPK1	0.71086498
64	CAMKK1	0.71065470
65	MAP2K4	0.70440214
66	SGK1	0.67834799
67	EEF2K	0.67547800
68	PDGFRA	0.59123101
69	CSNK1G1	0.57937263
70	RPS6KA2	0.53042385
71	EIF2AK1	0.52188439
72	PRKCE	0.50105538
73	MTOR	0.49832043
74	JAK1	0.49791297
75	CAMK2B	0.49324833
76	RPS6KA4	0.49019131
77	DYRK1B	0.43970216
78	ILK	0.42330215
79	PRKAA1	0.41996434
80	CDK6	0.41881086
81	MAP3K5	0.41829863
82	FER	0.41439432
83	YES1	0.39128852
84	PRKCQ	0.38335290
85	PKN2	0.38099082
86	NEK1	0.37347467
87	CDK19	0.35488763
88	MAPK10	0.35483923
89	CAMK2A	0.34209212
90	CHEK2	0.33374094
91	PHKG2	0.32758463
92	PHKG1	0.32758463
93	PNCK	0.32254171
94	NEK6	0.32084233
95	PRKCH	0.31961741
96	CDK14	0.31727405
97	RPS6KL1	0.31382966
98	RPS6KC1	0.31382966
99	WNK3	0.31220714
100	RAF1	0.29856394

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.54636369
2	GABAergic synapse_Homo sapiens_hsa04727	2.91735050
3	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.54677578
4	Dopaminergic synapse_Homo sapiens_hsa04728	2.54668972
5	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.47755048
6	Circadian entrainment_Homo sapiens_hsa04713	2.47497045
7	Morphine addiction_Homo sapiens_hsa05032	2.45658779
8	Glutamatergic synapse_Homo sapiens_hsa04724	2.16029320
9	Arginine biosynthesis_Homo sapiens_hsa00220	1.79657680
10	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.73619387
11	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.70214474
12	Long-term depression_Homo sapiens_hsa04730	1.64808519
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64249041
14	Axon guidance_Homo sapiens_hsa04360	1.54287514
15	Long-term potentiation_Homo sapiens_hsa04720	1.53436867
16	Cholinergic synapse_Homo sapiens_hsa04725	1.46118997
17	Regulation of autophagy_Homo sapiens_hsa04140	1.40190770
18	Amphetamine addiction_Homo sapiens_hsa05031	1.39198383
19	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.36299165
20	AMPK signaling pathway_Homo sapiens_hsa04152	1.35445439
21	Collecting duct acid secretion_Homo sapiens_hsa04966	1.24807345
22	Alcoholism_Homo sapiens_hsa05034	1.23210091
23	Lysine degradation_Homo sapiens_hsa00310	1.22897504
24	Glioma_Homo sapiens_hsa05214	1.11850076
25	mTOR signaling pathway_Homo sapiens_hsa04150	1.04957681
26	Serotonergic synapse_Homo sapiens_hsa04726	1.03401238
27	Gap junction_Homo sapiens_hsa04540	1.02680231
28	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.02027451
29	Cocaine addiction_Homo sapiens_hsa05030	0.99476066
30	Salivary secretion_Homo sapiens_hsa04970	0.99251255
31	Ras signaling pathway_Homo sapiens_hsa04014	0.99171069
32	mRNA surveillance pathway_Homo sapiens_hsa03015	0.98015032
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.97695829
34	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.96543700
35	Vibrio cholerae infection_Homo sapiens_hsa05110	0.94855335
36	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.92527677
37	Insulin secretion_Homo sapiens_hsa04911	0.91787689
38	Non-homologous end-joining_Homo sapiens_hsa03450	0.91362653
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.90756532
40	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.88117130
41	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.87921927
42	Renal cell carcinoma_Homo sapiens_hsa05211	0.87176623
43	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.86972909
44	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.85585637
45	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.84500298
46	Adherens junction_Homo sapiens_hsa04520	0.82593556
47	ErbB signaling pathway_Homo sapiens_hsa04012	0.82323841
48	Choline metabolism in cancer_Homo sapiens_hsa05231	0.82277007
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.81773355
50	Taste transduction_Homo sapiens_hsa04742	0.81377241
51	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.80240553
52	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.78969939
53	Colorectal cancer_Homo sapiens_hsa05210	0.78741200
54	Endocytosis_Homo sapiens_hsa04144	0.78303619
55	Propanoate metabolism_Homo sapiens_hsa00640	0.78046126
56	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.76717627
57	GnRH signaling pathway_Homo sapiens_hsa04912	0.76298423
58	Type II diabetes mellitus_Homo sapiens_hsa04930	0.73058129
59	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.72532866
60	Estrogen signaling pathway_Homo sapiens_hsa04915	0.71689535
61	Endometrial cancer_Homo sapiens_hsa05213	0.71609943
62	Phototransduction_Homo sapiens_hsa04744	0.70580752
63	Insulin signaling pathway_Homo sapiens_hsa04910	0.68490928
64	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.68318696
65	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.68217187
66	Prolactin signaling pathway_Homo sapiens_hsa04917	0.67866206
67	Hippo signaling pathway_Homo sapiens_hsa04390	0.67157463
68	Melanogenesis_Homo sapiens_hsa04916	0.67069671
69	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.66038021
70	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.65579531
71	Circadian rhythm_Homo sapiens_hsa04710	0.64440609
72	cAMP signaling pathway_Homo sapiens_hsa04024	0.64168697
73	Focal adhesion_Homo sapiens_hsa04510	0.61393482
74	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.60429115
75	Oocyte meiosis_Homo sapiens_hsa04114	0.59900120
76	Phagosome_Homo sapiens_hsa04145	0.57481594
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.56926423
78	One carbon pool by folate_Homo sapiens_hsa00670	0.56862397
79	Olfactory transduction_Homo sapiens_hsa04740	0.56515217
80	Rap1 signaling pathway_Homo sapiens_hsa04015	0.56395751
81	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.54756554
82	Non-small cell lung cancer_Homo sapiens_hsa05223	0.54240637
83	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.53932482
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.53308078
85	Gastric acid secretion_Homo sapiens_hsa04971	0.51175550
86	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.51058709
87	Renin secretion_Homo sapiens_hsa04924	0.50610883
88	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.50261894
89	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.50037787
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.49900280
91	Sulfur metabolism_Homo sapiens_hsa00920	0.46991952
92	Thyroid cancer_Homo sapiens_hsa05216	0.46233541
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.45901742
94	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.43032781
95	MicroRNAs in cancer_Homo sapiens_hsa05206	0.42612942
96	Pancreatic cancer_Homo sapiens_hsa05212	0.42509131
97	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.41215405
98	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.40196997
99	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.38966539
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.37321653

PIGCP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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