ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	5.15290025
2	cullin deneddylation (GO:0010388)	4.78926632
3	rRNA catabolic process (GO:0016075)	4.39982750
4	protein deneddylation (GO:0000338)	4.36506556
5	DNA double-strand break processing (GO:0000729)	4.36272639
6	ncRNA catabolic process (GO:0034661)	4.09433530
7	regulation of Golgi to plasma membrane protein transport (GO:0042996)	4.01421455
8	histone mRNA catabolic process (GO:0071044)	3.96589875
9	regulation of mitotic spindle checkpoint (GO:1903504)	3.90335051
10	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.90335051
11	neural tube formation (GO:0001841)	3.66307997
12	response to pheromone (GO:0019236)	3.55839661
13	axoneme assembly (GO:0035082)	3.55709430
14	proteasome assembly (GO:0043248)	3.51789476
15	head development (GO:0060322)	3.51738874
16	regulation of cilium movement (GO:0003352)	3.40288611
17	centriole replication (GO:0007099)	3.39880007
18	recombinational repair (GO:0000725)	3.29474981
19	signal peptide processing (GO:0006465)	3.25278567
20	double-strand break repair via homologous recombination (GO:0000724)	3.24348424
21	olfactory bulb development (GO:0021772)	3.15514737
22	intraciliary transport (GO:0042073)	3.14684919
23	histone mRNA metabolic process (GO:0008334)	3.12895927
24	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.11306838
25	phospholipid homeostasis (GO:0055091)	3.08292836
26	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.07209888
27	replication fork processing (GO:0031297)	3.06126150
28	galactose catabolic process (GO:0019388)	3.05770069
29	negative regulation of neurological system process (GO:0031645)	3.04922517
30	epithelial cilium movement (GO:0003351)	3.02834220
31	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.00893458
32	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.00694732
33	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.99975048
34	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.99708951
35	maturation of 5.8S rRNA (GO:0000460)	2.99231603
36	protein K11-linked deubiquitination (GO:0035871)	2.90930558
37	microtubule anchoring (GO:0034453)	2.90102928
38	adenosine metabolic process (GO:0046085)	2.88408656
39	nonmotile primary cilium assembly (GO:0035058)	2.88049106
40	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.86788394
41	isotype switching (GO:0045190)	2.86788394
42	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.86788394
43	respiratory chain complex IV assembly (GO:0008535)	2.79722046
44	proline transport (GO:0015824)	2.78546297
45	brain morphogenesis (GO:0048854)	2.78355827
46	vascular smooth muscle contraction (GO:0014829)	2.76733822
47	ovulation cycle (GO:0042698)	2.76027059
48	C4-dicarboxylate transport (GO:0015740)	2.74707322
49	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.73420630
50	mitochondrial RNA metabolic process (GO:0000959)	2.72235868
51	mRNA modification (GO:0016556)	2.71147152
52	regulation of centriole replication (GO:0046599)	2.71008994
53	kinetochore assembly (GO:0051382)	2.70668798
54	DNA replication-dependent nucleosome organization (GO:0034723)	2.70626983
55	DNA replication-dependent nucleosome assembly (GO:0006335)	2.70626983
56	cilium morphogenesis (GO:0060271)	2.69957776
57	regulation of cofactor metabolic process (GO:0051193)	2.69823618
58	regulation of coenzyme metabolic process (GO:0051196)	2.69823618
59	cytochrome complex assembly (GO:0017004)	2.69075413
60	cilium or flagellum-dependent cell motility (GO:0001539)	2.68160094
61	cellular response to leptin stimulus (GO:0044320)	2.66090137
62	DNA catabolic process, exonucleolytic (GO:0000738)	2.65371962
63	DNA ligation (GO:0006266)	2.64528721
64	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.64452394
65	negative regulation of membrane potential (GO:0045837)	2.63612728
66	bile acid biosynthetic process (GO:0006699)	2.63245709
67	negative regulation of systemic arterial blood pressure (GO:0003085)	2.63125038
68	histone H3-K9 methylation (GO:0051567)	2.61884885
69	negative regulation of DNA recombination (GO:0045910)	2.61623933
70	preassembly of GPI anchor in ER membrane (GO:0016254)	2.61101857
71	water-soluble vitamin biosynthetic process (GO:0042364)	2.60275510
72	establishment of protein localization to Golgi (GO:0072600)	2.60084767
73	transcription from mitochondrial promoter (GO:0006390)	2.58321352
74	branched-chain amino acid catabolic process (GO:0009083)	2.56831790
75	protein neddylation (GO:0045116)	2.56176744
76	presynaptic membrane assembly (GO:0097105)	2.55197578
77	protein localization to cilium (GO:0061512)	2.54911604
78	regulation of memory T cell differentiation (GO:0043380)	2.54894990
79	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.54105957
80	striatum development (GO:0021756)	2.53924370
81	C-terminal protein amino acid modification (GO:0018410)	2.52909067
82	mitotic spindle checkpoint (GO:0071174)	2.52695006
83	positive regulation of mitochondrial fission (GO:0090141)	2.50029435
84	chromatin remodeling at centromere (GO:0031055)	2.49551723
85	7-methylguanosine mRNA capping (GO:0006370)	2.49001089
86	spindle checkpoint (GO:0031577)	2.48783078
87	glial cell proliferation (GO:0014009)	2.48587725
88	behavioral response to nicotine (GO:0035095)	2.48040238
89	histone H2A acetylation (GO:0043968)	2.47616138
90	protein targeting to Golgi (GO:0000042)	2.46996371
91	non-recombinational repair (GO:0000726)	2.46586826
92	double-strand break repair via nonhomologous end joining (GO:0006303)	2.46586826
93	nephron epithelium morphogenesis (GO:0072088)	2.46562014
94	nephron tubule morphogenesis (GO:0072078)	2.46562014
95	cilium organization (GO:0044782)	2.46086370
96	positive regulation of DNA repair (GO:0045739)	2.45541932
97	C-terminal protein lipidation (GO:0006501)	2.45483060
98	double-strand break repair (GO:0006302)	2.45021585
99	regulation of sulfur metabolic process (GO:0042762)	2.44581875
100	regulation of cAMP-dependent protein kinase activity (GO:2000479)	2.44177605

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.39458950
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.37199594
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.26101472
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.22623720
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.94711504
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.60645958
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.54337803
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.51418667
9	FUS_26573619_Chip-Seq_HEK293_Human	2.45917429
10	VDR_22108803_ChIP-Seq_LS180_Human	2.41195077
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.37907084
12	EWS_26573619_Chip-Seq_HEK293_Human	2.32537252
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.31067999
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.21252876
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.19296131
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.13728122
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.07343550
18	ER_23166858_ChIP-Seq_MCF-7_Human	2.03522523
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.99089094
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.98932245
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.98821185
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.88822943
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.88687130
24	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.83201344
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.80171297
26	P300_19829295_ChIP-Seq_ESCs_Human	1.77613244
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.76630975
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75705951
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.73900426
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.73900426
31	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.64359943
32	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63345566
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61269780
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.58994469
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.58849302
36	VDR_23849224_ChIP-Seq_CD4+_Human	1.58723955
37	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.58562457
38	GATA1_22025678_ChIP-Seq_K562_Human	1.57240530
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.55589026
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.54243286
41	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.53271384
42	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.52334974
43	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.48931740
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46688474
45	E2F7_22180533_ChIP-Seq_HELA_Human	1.46543981
46	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.45748766
47	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.43805087
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43777980
49	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.43635977
50	STAT3_23295773_ChIP-Seq_U87_Human	1.42613674
51	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.37864223
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36894131
53	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.32610066
54	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32606200
55	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32573931
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.29884644
57	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.28542230
58	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.27661912
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26130734
60	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25929603
61	AR_25329375_ChIP-Seq_VCAP_Human	1.24770436
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24693503
63	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.24069509
64	FOXP3_21729870_ChIP-Seq_TREG_Human	1.24007483
65	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.23528573
66	TCF4_23295773_ChIP-Seq_U87_Human	1.23148874
67	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.21128250
68	P53_22387025_ChIP-Seq_ESCs_Mouse	1.19847767
69	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.19667307
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19561322
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19561322
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18679882
73	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.17826822
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15573196
75	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.15445440
76	TP53_22573176_ChIP-Seq_HFKS_Human	1.15365523
77	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.14932306
78	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.13408436
79	P300_18555785_Chip-Seq_ESCs_Mouse	1.13334065
80	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.11641261
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11554089
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10226564
83	TCF4_22108803_ChIP-Seq_LS180_Human	1.09965732
84	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09137173
85	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09137173
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09070890
87	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.07802552
88	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.07401811
89	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.07212077
90	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.06960504
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06838014
92	BCAT_22108803_ChIP-Seq_LS180_Human	1.06100522
93	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.05705175
94	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.04104112
95	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.03458940
96	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.02279098
97	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.01496219
98	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01407112
99	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.00961703
100	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99815611

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.83719794
2	MP0000569_abnormal_digit_pigmentation	3.68955445
3	MP0003880_abnormal_central_pattern	3.50293065
4	MP0008877_abnormal_DNA_methylation	3.45786823
5	MP0006072_abnormal_retinal_apoptosis	3.00642818
6	MP0008058_abnormal_DNA_repair	2.83475494
7	MP0010094_abnormal_chromosome_stability	2.81575521
8	MP0008057_abnormal_DNA_replication	2.76389816
9	MP0001984_abnormal_olfaction	2.53538203
10	MP0000427_abnormal_hair_cycle	2.50670465
11	MP0005253_abnormal_eye_physiology	2.45054031
12	MP0003787_abnormal_imprinting	2.24672216
13	MP0005551_abnormal_eye_electrophysiolog	2.16916083
14	MP0003195_calcinosis	2.12319935
15	MP0004215_abnormal_myocardial_fiber	2.11804812
16	MP0001986_abnormal_taste_sensitivity	1.90613757
17	MP0001485_abnormal_pinna_reflex	1.89564007
18	MP0004133_heterotaxia	1.82306847
19	MP0008775_abnormal_heart_ventricle	1.81806391
20	MP0002332_abnormal_exercise_endurance	1.71565034
21	MP0002234_abnormal_pharynx_morphology	1.71148429
22	MP0002254_reproductive_system_inflammat	1.69768453
23	MP0002837_dystrophic_cardiac_calcinosis	1.68981436
24	MP0001293_anophthalmia	1.68006972
25	MP0005248_abnormal_Harderian_gland	1.62534621
26	MP0003693_abnormal_embryo_hatching	1.57581763
27	MP0003890_abnormal_embryonic-extraembry	1.56664809
28	MP0000383_abnormal_hair_follicle	1.55545760
29	MP0005423_abnormal_somatic_nervous	1.50251483
30	MP0008789_abnormal_olfactory_epithelium	1.48277326
31	MP0002736_abnormal_nociception_after	1.46682293
32	MP0006036_abnormal_mitochondrial_physio	1.42832907
33	MP0004043_abnormal_pH_regulation	1.42135486
34	MP0003937_abnormal_limbs/digits/tail_de	1.41616023
35	MP0001324_abnormal_eye_pigmentation	1.37728659
36	MP0001486_abnormal_startle_reflex	1.31670245
37	MP0003121_genomic_imprinting	1.27793875
38	MP0005075_abnormal_melanosome_morpholog	1.26859266
39	MP0005391_vision/eye_phenotype	1.26117725
40	MP0000372_irregular_coat_pigmentation	1.25317034
41	MP0006035_abnormal_mitochondrial_morpho	1.24463977
42	MP0005408_hypopigmentation	1.23592096
43	MP0004084_abnormal_cardiac_muscle	1.23199334
44	MP0000015_abnormal_ear_pigmentation	1.20629599
45	MP0005266_abnormal_metabolism	1.20065269
46	MP0002090_abnormal_vision	1.18521423
47	MP0008932_abnormal_embryonic_tissue	1.15121906
48	MP0009046_muscle_twitch	1.12006186
49	MP0005195_abnormal_posterior_eye	1.10608208
50	MP0001764_abnormal_homeostasis	1.10449557
51	MP0001968_abnormal_touch/_nociception	1.09376245
52	MP0002751_abnormal_autonomic_nervous	1.06569645
53	MP0002233_abnormal_nose_morphology	1.06289371
54	MP0003718_maternal_effect	1.06242479
55	MP0006276_abnormal_autonomic_nervous	1.02668097
56	MP0001177_atelectasis	1.02394191
57	MP0005499_abnormal_olfactory_system	1.02230765
58	MP0005394_taste/olfaction_phenotype	1.02230765
59	MP0004782_abnormal_surfactant_physiolog	1.01916255
60	MP0003136_yellow_coat_color	1.01487621
61	MP0002177_abnormal_outer_ear	1.00437274
62	MP0002095_abnormal_skin_pigmentation	0.98407877
63	MP0002938_white_spotting	0.98307604
64	MP0003221_abnormal_cardiomyocyte_apopto	0.98193733
65	MP0000358_abnormal_cell_content/	0.95356116
66	MP0001919_abnormal_reproductive_system	0.93568717
67	MP0010678_abnormal_skin_adnexa	0.93223500
68	MP0005410_abnormal_fertilization	0.92840477
69	MP0002127_abnormal_cardiovascular_syste	0.92074519
70	MP0003567_abnormal_fetal_cardiomyocyte	0.91023044
71	MP0000647_abnormal_sebaceous_gland	0.89018776
72	MP0009697_abnormal_copulation	0.87999042
73	MP0005310_abnormal_salivary_gland	0.85827935
74	MP0001529_abnormal_vocalization	0.85753071
75	MP0004197_abnormal_fetal_growth/weight/	0.85682218
76	MP0001286_abnormal_eye_development	0.85577919
77	MP0005379_endocrine/exocrine_gland_phen	0.84687789
78	MP0002928_abnormal_bile_duct	0.84425727
79	MP0005220_abnormal_exocrine_pancreas	0.83078452
80	MP0002752_abnormal_somatic_nervous	0.81626554
81	MP0002638_abnormal_pupillary_reflex	0.81124353
82	MP0004484_altered_response_of	0.81083507
83	MP0003077_abnormal_cell_cycle	0.81027505
84	MP0004085_abnormal_heartbeat	0.79960665
85	MP0000579_abnormal_nail_morphology	0.79182435
86	MP0006292_abnormal_olfactory_placode	0.79033593
87	MP0003806_abnormal_nucleotide_metabolis	0.78230872
88	MP0004742_abnormal_vestibular_system	0.77803569
89	MP0002229_neurodegeneration	0.76183902
90	MP0009745_abnormal_behavioral_response	0.75548788
91	MP0008872_abnormal_physiological_respon	0.75287292
92	MP0004885_abnormal_endolymph	0.75110197
93	MP0002697_abnormal_eye_size	0.74996476
94	MP0003656_abnormal_erythrocyte_physiolo	0.74502100
95	MP0002282_abnormal_trachea_morphology	0.73421283
96	MP0008875_abnormal_xenobiotic_pharmacok	0.72161392
97	MP0003111_abnormal_nucleus_morphology	0.70660133
98	MP0005389_reproductive_system_phenotype	0.70195990
99	MP0000613_abnormal_salivary_gland	0.68873411
100	MP0003938_abnormal_ear_development	0.68194367

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intestinal atresia (HP:0011100)	4.25530951
2	Progressive inability to walk (HP:0002505)	3.78575481
3	Chronic hepatic failure (HP:0100626)	3.40478867
4	Volvulus (HP:0002580)	3.37393739
5	Gonadotropin excess (HP:0000837)	3.36096515
6	Medial flaring of the eyebrow (HP:0010747)	3.13466971
7	Pancreatic fibrosis (HP:0100732)	3.12864800
8	Molar tooth sign on MRI (HP:0002419)	3.00674344
9	Abnormality of midbrain morphology (HP:0002418)	3.00674344
10	Supernumerary spleens (HP:0009799)	2.87573454
11	Abolished electroretinogram (ERG) (HP:0000550)	2.80321864
12	True hermaphroditism (HP:0010459)	2.74744550
13	Epidermoid cyst (HP:0200040)	2.73028544
14	Abnormality of alanine metabolism (HP:0010916)	2.72555364
15	Hyperalaninemia (HP:0003348)	2.72555364
16	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.72555364
17	Congenital primary aphakia (HP:0007707)	2.70652618
18	Nephronophthisis (HP:0000090)	2.70489440
19	Gait imbalance (HP:0002141)	2.67144947
20	Abnormal biliary tract physiology (HP:0012439)	2.63747918
21	Bile duct proliferation (HP:0001408)	2.63747918
22	Pancreatic cysts (HP:0001737)	2.57278509
23	Abnormality of macular pigmentation (HP:0008002)	2.52521866
24	Nephrogenic diabetes insipidus (HP:0009806)	2.50147773
25	Aqueductal stenosis (HP:0002410)	2.44696441
26	Central scotoma (HP:0000603)	2.42968391
27	Duodenal stenosis (HP:0100867)	2.39013466
28	Small intestinal stenosis (HP:0012848)	2.39013466
29	Abnormality of the renal cortex (HP:0011035)	2.34511632
30	Posterior subcapsular cataract (HP:0007787)	2.34099428
31	Atonic seizures (HP:0010819)	2.33777777
32	Tubulointerstitial nephritis (HP:0001970)	2.30780887
33	Abnormality of the duodenum (HP:0002246)	2.30454143
34	Abnormality of the labia minora (HP:0012880)	2.30386352
35	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.28079581
36	Abnormality of the renal medulla (HP:0100957)	2.27087087
37	Methylmalonic acidemia (HP:0002912)	2.26178357
38	Abnormality of chromosome stability (HP:0003220)	2.20530379
39	Abnormality of the astrocytes (HP:0100707)	2.18579742
40	Astrocytoma (HP:0009592)	2.18579742
41	Meckel diverticulum (HP:0002245)	2.18120357
42	Birth length less than 3rd percentile (HP:0003561)	2.16850265
43	Abnormality of the ileum (HP:0001549)	2.16444473
44	Severe visual impairment (HP:0001141)	2.15527267
45	Hypoplasia of the fovea (HP:0007750)	2.14843269
46	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.14843269
47	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.11440238
48	Ependymoma (HP:0002888)	2.10766350
49	Sloping forehead (HP:0000340)	2.09840192
50	Renal cortical cysts (HP:0000803)	2.08373355
51	Alveolar cell carcinoma (HP:0006519)	2.07432854
52	Increased serum pyruvate (HP:0003542)	2.07022988
53	Congenital stationary night blindness (HP:0007642)	2.06944461
54	Glioma (HP:0009733)	2.06016802
55	Abnormality of the left ventricular outflow tract (HP:0011103)	2.05605111
56	Subaortic stenosis (HP:0001682)	2.05605111
57	Oculomotor apraxia (HP:0000657)	2.04949531
58	Inability to walk (HP:0002540)	2.04812016
59	Neoplasm of the tracheobronchial system (HP:0100552)	2.04294510
60	Postaxial foot polydactyly (HP:0001830)	2.03602289
61	Abnormality of the preputium (HP:0100587)	2.03191775
62	Increased CSF lactate (HP:0002490)	2.02681802
63	Abnormality of the fovea (HP:0000493)	2.00024853
64	Dyschromatopsia (HP:0007641)	1.98751540
65	Broad foot (HP:0001769)	1.98195562
66	Gastrointestinal atresia (HP:0002589)	1.97845511
67	Embryonal renal neoplasm (HP:0011794)	1.97443771
68	Poor coordination (HP:0002370)	1.97320820
69	Genital tract atresia (HP:0001827)	1.96468434
70	Abnormality of glycolysis (HP:0004366)	1.95628571
71	Abnormal lung lobation (HP:0002101)	1.93861484
72	Absent radius (HP:0003974)	1.93375864
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92077118
74	Vaginal atresia (HP:0000148)	1.91422979
75	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.90657604
76	Astigmatism (HP:0000483)	1.86873746
77	Absent forearm bone (HP:0003953)	1.86732892
78	Aplasia involving forearm bones (HP:0009822)	1.86732892
79	Hypobetalipoproteinemia (HP:0003563)	1.85694261
80	Progressive macrocephaly (HP:0004481)	1.85608589
81	Pheochromocytoma (HP:0002666)	1.84361951
82	Decreased testicular size (HP:0008734)	1.82286559
83	Acute necrotizing encephalopathy (HP:0006965)	1.81922563
84	Nephroblastoma (Wilms tumor) (HP:0002667)	1.81046971
85	Drooling (HP:0002307)	1.80842389
86	Furrowed tongue (HP:0000221)	1.78106716
87	Postaxial hand polydactyly (HP:0001162)	1.76470646
88	Horizontal nystagmus (HP:0000666)	1.75770137
89	Facial diplegia (HP:0001349)	1.75553530
90	Short tibia (HP:0005736)	1.75266495
91	Abnormal pancreas size (HP:0012094)	1.74913274
92	Type I transferrin isoform profile (HP:0003642)	1.74144402
93	Asplenia (HP:0001746)	1.73621489
94	Sclerocornea (HP:0000647)	1.73443701
95	Delayed gross motor development (HP:0002194)	1.73024603
96	Myelodysplasia (HP:0002863)	1.70937734
97	Acute encephalopathy (HP:0006846)	1.70200429
98	Amyotrophic lateral sclerosis (HP:0007354)	1.69299487
99	Long clavicles (HP:0000890)	1.69040582
100	Increased density of long bones (HP:0006392)	1.68477271

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	4.50469835
2	FRK	3.66395992
3	BCR	3.41913628
4	SRPK1	2.82867134
5	CAMKK2	2.44761900
6	MKNK1	2.27876468
7	TSSK6	2.21054645
8	PAK3	2.10239272
9	SIK3	2.05151641
10	NUAK1	2.02018505
11	ERBB3	2.00836129
12	PLK3	1.95115538
13	MAP3K4	1.94387437
14	WNK3	1.86705190
15	MAP4K2	1.81575093
16	PDK2	1.81506118
17	EIF2AK3	1.80553056
18	BCKDK	1.74985025
19	PNCK	1.73189152
20	PBK	1.72313221
21	ERBB4	1.64663465
22	PLK2	1.64443149
23	MKNK2	1.58667203
24	TTK	1.57033098
25	PIK3CA	1.53271310
26	MAP2K7	1.49444160
27	CASK	1.48302256
28	MAPK13	1.44946957
29	EIF2AK1	1.43430195
30	PLK4	1.42259618
31	BMPR1B	1.33724567
32	CSNK1A1L	1.28467374
33	MINK1	1.27953938
34	GRK1	1.25241277
35	DYRK3	1.24068726
36	BUB1	1.17829414
37	CSNK1G3	1.17684782
38	ZAK	1.15074063
39	CSNK1G1	1.07557513
40	BRSK2	1.02531571
41	ADRBK2	1.02004277
42	NEK6	0.97533934
43	AKT3	0.97104957
44	PTK2B	0.90316206
45	ACVR1B	0.88540410
46	FER	0.88491483
47	PRKCE	0.86343522
48	CSNK1G2	0.84253599
49	VRK1	0.82653313
50	WEE1	0.82047569
51	CAMK4	0.81226335
52	BRD4	0.81058803
53	OXSR1	0.80709809
54	PINK1	0.80164326
55	INSRR	0.79153336
56	MST4	0.79100918
57	DYRK1A	0.77300289
58	CHEK2	0.76166611
59	PKN1	0.76080168
60	NEK1	0.74081104
61	CDK3	0.70863405
62	EPHA4	0.70128103
63	MST1R	0.69374544
64	RPS6KA4	0.66784126
65	PRKCI	0.63588561
66	FGFR1	0.63088112
67	BRSK1	0.61342859
68	ATR	0.60534558
69	YES1	0.59446695
70	CDK19	0.58907704
71	CAMK2A	0.58831258
72	MARK1	0.58321558
73	ATM	0.56417550
74	PLK1	0.55950555
75	MAP2K4	0.55212876
76	OBSCN	0.46744899
77	TEC	0.46444190
78	STK4	0.45217685
79	ADRBK1	0.43000890
80	PRKCG	0.42455159
81	LATS1	0.41419532
82	BRAF	0.41226944
83	TNIK	0.40721987
84	MAPK11	0.40590701
85	TLK1	0.40525007
86	ERBB2	0.38077422
87	CDK9	0.37523232
88	CDC7	0.37149847
89	PAK6	0.36894746
90	STK39	0.36886757
91	ABL1	0.35905811
92	ALK	0.34014572
93	CSNK2A1	0.33730785
94	STK3	0.33419378
95	TAF1	0.33272473
96	PRKACB	0.31290431
97	CSNK1A1	0.30943859
98	KSR1	0.28872124
99	CHEK1	0.28653501
100	EGFR	0.27812998

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.99570971
2	Propanoate metabolism_Homo sapiens_hsa00640	2.98565070
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.94146715
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.80749594
5	Proteasome_Homo sapiens_hsa03050	2.78271403
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.66828727
7	RNA degradation_Homo sapiens_hsa03018	2.60272087
8	RNA polymerase_Homo sapiens_hsa03020	2.53720618
9	Basal transcription factors_Homo sapiens_hsa03022	2.40942878
10	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.37903494
11	Protein export_Homo sapiens_hsa03060	2.34321865
12	Non-homologous end-joining_Homo sapiens_hsa03450	2.33089247
13	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.25953712
14	Homologous recombination_Homo sapiens_hsa03440	2.14404705
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.11482388
16	Phototransduction_Homo sapiens_hsa04744	2.02927337
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.88649533
18	Peroxisome_Homo sapiens_hsa04146	1.73598526
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.71970660
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.68674442
21	Butanoate metabolism_Homo sapiens_hsa00650	1.66004764
22	Caffeine metabolism_Homo sapiens_hsa00232	1.59918394
23	One carbon pool by folate_Homo sapiens_hsa00670	1.58172268
24	Steroid biosynthesis_Homo sapiens_hsa00100	1.50559108
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.44575325
26	Mismatch repair_Homo sapiens_hsa03430	1.32445072
27	Collecting duct acid secretion_Homo sapiens_hsa04966	1.28472401
28	Fatty acid elongation_Homo sapiens_hsa00062	1.26788117
29	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.26691101
30	Pyruvate metabolism_Homo sapiens_hsa00620	1.25244782
31	Fatty acid metabolism_Homo sapiens_hsa01212	1.19942244
32	RNA transport_Homo sapiens_hsa03013	1.16935247
33	Olfactory transduction_Homo sapiens_hsa04740	1.16711991
34	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.10277080
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.09219421
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.08965553
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.08523239
38	Fatty acid degradation_Homo sapiens_hsa00071	1.07719585
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.05492382
40	Retinol metabolism_Homo sapiens_hsa00830	0.99826407
41	ABC transporters_Homo sapiens_hsa02010	0.98752647
42	Pyrimidine metabolism_Homo sapiens_hsa00240	0.97123798
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.96514199
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.96190935
45	Parkinsons disease_Homo sapiens_hsa05012	0.96158637
46	Cell cycle_Homo sapiens_hsa04110	0.95685687
47	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.94666063
48	Spliceosome_Homo sapiens_hsa03040	0.93637974
49	Folate biosynthesis_Homo sapiens_hsa00790	0.93590238
50	Purine metabolism_Homo sapiens_hsa00230	0.91766267
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.91465000
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.90828079
53	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.89907257
54	Oxidative phosphorylation_Homo sapiens_hsa00190	0.89641269
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.89036287
56	Base excision repair_Homo sapiens_hsa03410	0.85619954
57	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.83381925
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.83244019
59	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.82943791
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.80303792
61	Linoleic acid metabolism_Homo sapiens_hsa00591	0.74829514
62	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.74047344
63	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.72665392
64	Oocyte meiosis_Homo sapiens_hsa04114	0.72362272
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72177859
66	Huntingtons disease_Homo sapiens_hsa05016	0.70146104
67	Taste transduction_Homo sapiens_hsa04742	0.69539044
68	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.68663304
69	Nicotine addiction_Homo sapiens_hsa05033	0.68444405
70	mRNA surveillance pathway_Homo sapiens_hsa03015	0.66993952
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66347604
72	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.65009753
73	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.64310314
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63712158
75	Legionellosis_Homo sapiens_hsa05134	0.62075106
76	Metabolic pathways_Homo sapiens_hsa01100	0.60889126
77	Asthma_Homo sapiens_hsa05310	0.60366198
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.58099798
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55807688
80	Lysine degradation_Homo sapiens_hsa00310	0.55192631
81	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54633184
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.54183708
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.50924446
84	DNA replication_Homo sapiens_hsa03030	0.45009927
85	Circadian entrainment_Homo sapiens_hsa04713	0.44366924
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43071711
87	Circadian rhythm_Homo sapiens_hsa04710	0.42554138
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.41428851
89	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.40158667
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39654906
91	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.39231793
92	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.39108317
93	Regulation of autophagy_Homo sapiens_hsa04140	0.34100889
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.31322576
95	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.31072302
96	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.28496085
97	Glutathione metabolism_Homo sapiens_hsa00480	0.27666900
98	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.27181618
99	Sulfur metabolism_Homo sapiens_hsa00920	0.23232201
100	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.21869432

PIGFP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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