PIGG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme involved in glycosylphosphatidylinositol-anchor biosynthesis. The encoded protein, which is localized to the endoplasmic reticulum, is involved in transferring ethanoloamine phosphate to mannose 2 of glycosylphosphatidylinositol species H7 to form species H8. Allelic variants of this gene have been associated with intellectual disability, hypotonia, and early-onset seizures. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.19193128
2L-phenylalanine catabolic process (GO:0006559)5.19193128
3alpha-linolenic acid metabolic process (GO:0036109)4.99516064
4L-phenylalanine metabolic process (GO:0006558)4.90080861
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.90080861
6cysteine metabolic process (GO:0006534)4.84179841
7lysine metabolic process (GO:0006553)4.79297915
8lysine catabolic process (GO:0006554)4.79297915
9fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.58609367
10mannose metabolic process (GO:0006013)4.39694967
11response to muramyl dipeptide (GO:0032495)4.29490689
12glyoxylate metabolic process (GO:0046487)4.28319606
13hemidesmosome assembly (GO:0031581)4.27738136
14aromatic amino acid family catabolic process (GO:0009074)4.27632289
15positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.22119387
16bile acid biosynthetic process (GO:0006699)4.14275444
17sulfur amino acid catabolic process (GO:0000098)4.11355454
18regulation of cholesterol homeostasis (GO:2000188)3.96243872
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.92456546
20amino-acid betaine metabolic process (GO:0006577)3.90342807
21short-chain fatty acid metabolic process (GO:0046459)3.89749063
22cellular ketone body metabolic process (GO:0046950)3.85430826
23negative regulation of glycoprotein biosynthetic process (GO:0010561)3.82935294
24kynurenine metabolic process (GO:0070189)3.78917470
25fatty acid beta-oxidation (GO:0006635)3.75026785
26glutamate metabolic process (GO:0006536)3.72488587
27bile acid metabolic process (GO:0008206)3.71202084
28aspartate family amino acid catabolic process (GO:0009068)3.70676166
29fatty acid oxidation (GO:0019395)3.70257698
302-oxoglutarate metabolic process (GO:0006103)3.68647060
31homocysteine metabolic process (GO:0050667)3.62346549
32peptidyl-glutamic acid carboxylation (GO:0017187)3.61501774
33protein carboxylation (GO:0018214)3.61501774
34lipid oxidation (GO:0034440)3.60397645
35serine family amino acid catabolic process (GO:0009071)3.58860647
36urea cycle (GO:0000050)3.58238493
37urea metabolic process (GO:0019627)3.58238493
38dicarboxylic acid biosynthetic process (GO:0043650)3.58103387
39valine metabolic process (GO:0006573)3.57805456
40drug transmembrane transport (GO:0006855)3.56525030
41urate metabolic process (GO:0046415)3.51684722
42negative regulation of cAMP-mediated signaling (GO:0043951)3.51106706
43drug catabolic process (GO:0042737)3.50556433
44regulation of protein activation cascade (GO:2000257)3.49732994
45negative regulation of cell killing (GO:0031342)3.48811696
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.48811696
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.46792044
48indole-containing compound catabolic process (GO:0042436)3.45724853
49indolalkylamine catabolic process (GO:0046218)3.45724853
50tryptophan catabolic process (GO:0006569)3.45724853
51regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.44076272
52fatty acid catabolic process (GO:0009062)3.42065414
53high-density lipoprotein particle remodeling (GO:0034375)3.41975057
54cellular modified amino acid catabolic process (GO:0042219)3.35312955
55complement activation, alternative pathway (GO:0006957)3.34404954
56ketone body metabolic process (GO:1902224)3.33998879
57tryptophan metabolic process (GO:0006568)3.33900314
58ethanol oxidation (GO:0006069)3.32724613
59regulation of complement activation (GO:0030449)3.32582442
60acetyl-CoA metabolic process (GO:0006084)3.31635260
61carnitine metabolic process (GO:0009437)3.28235567
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28033694
63alpha-amino acid catabolic process (GO:1901606)3.27666797
64positive regulation of gamma-delta T cell activation (GO:0046645)3.27497276
65negative regulation of fibrinolysis (GO:0051918)3.26949656
66monocarboxylic acid catabolic process (GO:0072329)3.26160992
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.25832925
68phospholipid homeostasis (GO:0055091)3.24974291
69regulation of triglyceride catabolic process (GO:0010896)3.23452251
70tricarboxylic acid metabolic process (GO:0072350)3.22698742
71fatty acid transmembrane transport (GO:1902001)3.22633855
72triglyceride homeostasis (GO:0070328)3.21727728
73acylglycerol homeostasis (GO:0055090)3.21727728
74biotin metabolic process (GO:0006768)3.21224059
75negative regulation of erythrocyte differentiation (GO:0045647)3.21096239
76cellular glucuronidation (GO:0052695)3.20967369
77negative regulation of sterol transport (GO:0032372)3.19325994
78negative regulation of cholesterol transport (GO:0032375)3.19325994
79nitrogen cycle metabolic process (GO:0071941)3.19054239
80positive regulation of glycolytic process (GO:0045821)3.18209755
81cellular amino acid catabolic process (GO:0009063)3.18182760
82tyrosine metabolic process (GO:0006570)3.15959410
83regulation of histone H3-K27 methylation (GO:0061085)3.13627048
84regulation of fatty acid beta-oxidation (GO:0031998)3.12039556
85negative regulation of lipase activity (GO:0060192)3.10656080
86carnitine transport (GO:0015879)3.09609406
87amino-acid betaine transport (GO:0015838)3.09609406
88carnitine shuttle (GO:0006853)3.09234247
89regulation of bile acid biosynthetic process (GO:0070857)3.08587022
90activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.06523171
91exogenous drug catabolic process (GO:0042738)3.03758111
92negative regulation of nitric oxide biosynthetic process (GO:0045019)3.03739288
93plasma lipoprotein particle clearance (GO:0034381)3.03468832
94serine family amino acid metabolic process (GO:0009069)3.02943756
95regulation of fibrinolysis (GO:0051917)3.02297115
96macroautophagy (GO:0016236)3.01553913
97regulation of necroptotic process (GO:0060544)3.01464107
98reverse cholesterol transport (GO:0043691)3.00817874
99aromatic amino acid family metabolic process (GO:0009072)2.99658398
100response to mercury ion (GO:0046689)2.99374541
101organic acid catabolic process (GO:0016054)2.99084033
102carboxylic acid catabolic process (GO:0046395)2.99084033
103ethanol metabolic process (GO:0006067)2.98499544
104antigen processing and presentation of endogenous antigen (GO:0019883)2.98188824
105thymic T cell selection (GO:0045061)2.93808471
106drug transport (GO:0015893)2.91518696
107cell-substrate junction assembly (GO:0007044)2.88831506
108positive regulation of lipid catabolic process (GO:0050996)2.87737560
109quaternary ammonium group transport (GO:0015697)2.87214277
110phospholipid efflux (GO:0033700)2.87129214
111carnitine transmembrane transport (GO:1902603)2.86868622
112benzene-containing compound metabolic process (GO:0042537)2.85894417
113desmosome organization (GO:0002934)2.84455675
114phosphate ion transport (GO:0006817)2.84306758
115cholesterol efflux (GO:0033344)2.83744328
116negative regulation of granulocyte differentiation (GO:0030853)2.83120168
117histone H3-K36 demethylation (GO:0070544)2.82319422
118sphingosine metabolic process (GO:0006670)2.80888606
119plasma lipoprotein particle remodeling (GO:0034369)2.80684658
120protein-lipid complex remodeling (GO:0034368)2.80684658
121macromolecular complex remodeling (GO:0034367)2.80684658
122negative regulation of glycoprotein metabolic process (GO:1903019)2.80437634
123intestinal cholesterol absorption (GO:0030299)2.80209899
124positive regulation of fatty acid oxidation (GO:0046321)2.80052093
125COPI coating of Golgi vesicle (GO:0048205)2.79067275
126Golgi transport vesicle coating (GO:0048200)2.79067275
127cellular response to virus (GO:0098586)2.78770799
128negative thymic T cell selection (GO:0045060)2.74737054
129protein localization to endosome (GO:0036010)2.72215466
130positive thymic T cell selection (GO:0045059)2.71763292
131leukocyte aggregation (GO:0070486)2.68953249
132germinal center formation (GO:0002467)2.67621773
133regulation of gamma-delta T cell differentiation (GO:0045586)2.67335629
134regulation of gamma-delta T cell activation (GO:0046643)2.63037091
135negative regulation of fatty acid transport (GO:2000192)2.59067581
136negative regulation of cell size (GO:0045792)2.54842555
137cellular response to ethanol (GO:0071361)2.51808887
138tolerance induction (GO:0002507)2.51691588
139negative T cell selection (GO:0043383)2.50723494
140opioid receptor signaling pathway (GO:0038003)2.49428994
141white fat cell differentiation (GO:0050872)2.45501786
142regulation of type I interferon-mediated signaling pathway (GO:0060338)2.44854464
143cellular response to exogenous dsRNA (GO:0071360)2.44806403
144negative regulation of viral release from host cell (GO:1902187)2.43401678
145positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.43375571
146regulation of monocyte differentiation (GO:0045655)2.42819879
147negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.41272537
148positive regulation of cholesterol efflux (GO:0010875)2.39535454
149negative regulation of innate immune response (GO:0045824)2.38999459
150B cell receptor signaling pathway (GO:0050853)2.38923697
151regulation of memory T cell differentiation (GO:0043380)2.38712860
152regulation of ARF protein signal transduction (GO:0032012)2.38388164
153negative regulation of T cell mediated immunity (GO:0002710)2.36820625
154regulation of antigen processing and presentation (GO:0002577)2.36237648
155T cell selection (GO:0045058)2.35219853
156sphingoid metabolic process (GO:0046519)2.33937658
157positive regulation of blood vessel endothelial cell migration (GO:0043536)2.32116063
158diol metabolic process (GO:0034311)2.30652842
159hypotonic response (GO:0006971)2.29713816
160retrograde transport, endosome to Golgi (GO:0042147)2.29066731
161response to laminar fluid shear stress (GO:0034616)2.28769428
162negative regulation of interleukin-6 production (GO:0032715)2.28229618
163regulation of extracellular matrix disassembly (GO:0010715)2.26695769
164antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.25996034
165positive regulation of T cell mediated cytotoxicity (GO:0001916)2.25960748
166wound healing, spreading of epidermal cells (GO:0035313)2.23670734
167regulation of plasminogen activation (GO:0010755)2.23393396
168negative regulation of interleukin-2 production (GO:0032703)2.23078436
169regulation of T cell mediated cytotoxicity (GO:0001914)2.22762665
170epithelial cell differentiation involved in prostate gland development (GO:0060742)2.21569431
171response to type I interferon (GO:0034340)2.21483500
172wound healing, spreading of cells (GO:0044319)2.21393893
173cell adhesion mediated by integrin (GO:0033627)2.20336350
174activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.19652462
175immunoglobulin mediated immune response (GO:0016064)2.19219545
176interferon-gamma secretion (GO:0072643)2.19192571
177negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.17833919
178type I interferon signaling pathway (GO:0060337)2.17445155
179cellular response to type I interferon (GO:0071357)2.17445155
180striated muscle atrophy (GO:0014891)2.16657513
181semaphorin-plexin signaling pathway (GO:0071526)2.16514870
182dosage compensation (GO:0007549)2.16241208
183glomerular basement membrane development (GO:0032836)2.15551835
184response to lipoprotein particle (GO:0055094)2.15062770
185retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.14609563
186regulation of necrotic cell death (GO:0010939)2.14542101
187surfactant homeostasis (GO:0043129)2.14132352
188pinocytosis (GO:0006907)2.13829709
189negative regulation of lymphocyte mediated immunity (GO:0002707)2.13077744
190positive regulation of CREB transcription factor activity (GO:0032793)2.12754477
191insulin-like growth factor receptor signaling pathway (GO:0048009)2.12570642
192embryonic process involved in female pregnancy (GO:0060136)2.11362406
193spliceosomal tri-snRNP complex assembly (GO:0000244)2.10873586
194activation of JUN kinase activity (GO:0007257)2.09492902
195regulation of interferon-beta biosynthetic process (GO:0045357)2.07156640
196protein hydroxylation (GO:0018126)2.06701636
197histone H3-K4 methylation (GO:0051568)2.06193028
198NIK/NF-kappaB signaling (GO:0038061)2.06136860
199negative regulation of cytosolic calcium ion concentration (GO:0051481)2.05130885

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.22549747
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.27112387
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.61721159
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.47340986
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.96111317
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.38486182
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.34119492
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.29764484
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.22439562
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.12735160
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.81339394
12VDR_21846776_ChIP-Seq_THP-1_Human2.79703617
13GATA1_22025678_ChIP-Seq_K562_Human2.71344051
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.44817179
15MYC_22102868_ChIP-Seq_BL_Human2.40191145
16CLOCK_20551151_ChIP-Seq_293T_Human2.36181710
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.34803707
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32843619
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.31143540
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.25081096
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.24381201
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24063507
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18099100
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10721676
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.09685097
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00129084
27TCF7_22412390_ChIP-Seq_EML_Mouse1.98938843
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97368698
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91375648
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90872668
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.88376549
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.85245986
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.84604815
34ZNF263_19887448_ChIP-Seq_K562_Human1.84428250
35TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.83783811
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.78299657
37VDR_24763502_ChIP-Seq_THP-1_Human1.77300366
38MAF_26560356_Chip-Seq_TH1_Human1.76184472
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76151350
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.74674405
41RACK7_27058665_Chip-Seq_MCF-7_Human1.71295007
42KDM2B_26808549_Chip-Seq_DND41_Human1.67758320
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66655842
44TP53_22127205_ChIP-Seq_IMR90_Human1.63731649
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.60742203
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.59489786
47SPI1_23127762_ChIP-Seq_K562_Human1.55827311
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55524977
49UTX_26944678_Chip-Seq_JUKART_Human1.54855740
50MAF_26560356_Chip-Seq_TH2_Human1.54101908
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53325477
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52452085
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52325305
54SCL_19346495_ChIP-Seq_HPC-7_Human1.51178672
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50884526
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50327384
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.48843667
58RUNX_20019798_ChIP-Seq_JUKART_Human1.47727409
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45539290
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.45394397
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44634697
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.40417520
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40235075
64IRF8_27001747_Chip-Seq_BMDM_Mouse1.39486002
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.39119882
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37412439
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36697965
68MYB_26560356_Chip-Seq_TH1_Human1.35625564
69* GATA1_19941827_ChIP-Seq_MEL_Mouse1.34900895
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34491852
71STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33942311
72* P68_20966046_ChIP-Seq_HELA_Human1.33918233
73MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33908118
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33599639
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.32705254
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30431837
77CIITA_25753668_ChIP-Seq_RAJI_Human1.30187728
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27526829
79* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27271909
80SMC4_20622854_ChIP-Seq_HELA_Human1.27076888
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25794916
82BCAT_22108803_ChIP-Seq_LS180_Human1.24884418
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24409196
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.23922723
85KDM2B_26808549_Chip-Seq_K562_Human1.22280026
86HNF4A_19822575_ChIP-Seq_HepG2_Human1.21925172
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21283321
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20523142
89MYB_26560356_Chip-Seq_TH2_Human1.20298756
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19312955
91BCOR_27268052_Chip-Seq_Bcells_Human1.18145442
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17851155
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17529053
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17378648
95* TP63_22573176_ChIP-Seq_HFKS_Human1.17230991
96GATA4_25053715_ChIP-Seq_YYC3_Human1.16887912
97ATF3_27146783_Chip-Seq_COLON_Human1.15473094
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.15398045
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15196425
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14595088
101NCOR1_26117541_ChIP-Seq_K562_Human1.14396134
102AHR_22903824_ChIP-Seq_MCF-7_Human1.13530435
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12045599
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11778038
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11696542
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11696542
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11471294
108GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10419691
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09545404
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07978740
111STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07953524
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07907204
113GATA3_27048872_Chip-Seq_THYMUS_Human1.07342753
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.07153800
115HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06850956
116PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05829992
117VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05475567
118CREB1_26743006_Chip-Seq_LNCaP_Human1.04006077
119SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03719414
120SA1_27219007_Chip-Seq_ERYTHROID_Human1.03286843
121* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02890284
122CDX2_20551321_ChIP-Seq_CACO-2_Human1.02395707
123TP53_16413492_ChIP-PET_HCT116_Human1.01561865
124EP300_21415370_ChIP-Seq_HL-1_Mouse1.00612209
125PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00560216
126TBX20_22328084_ChIP-Seq_HEART_Mouse0.99830140
127TBX20_22080862_ChIP-Seq_HEART_Mouse0.99830140
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99673686
129GATA6_25053715_ChIP-Seq_YYC3_Human0.98583378
130* ELF1_20517297_ChIP-Seq_JURKAT_Human0.98359761
131SPI1_23547873_ChIP-Seq_NB4_Human0.97689900
132* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97161614
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96901374
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96568492
135UBF1/2_26484160_Chip-Seq_HMECs_Human0.95232573
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94914108
137ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94638374
138NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93132305
139NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93132305
140SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92417750
141ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91346978
142RXR_22108803_ChIP-Seq_LS180_Human0.90365781
143SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89132491
144ARNT_22903824_ChIP-Seq_MCF-7_Human0.88665809
145WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87631568
146SOX2_20726797_ChIP-Seq_SW620_Human0.86682616
147SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86064694
148DROSHA_22980978_ChIP-Seq_HELA_Human0.84338149
149FOXA1_25552417_ChIP-Seq_VCAP_Human0.84152525
150RUNX1_27514584_Chip-Seq_MCF-7_Human0.83547109
151ZNF274_21170338_ChIP-Seq_K562_Hela0.83425296
152TP63_23658742_ChIP-Seq_EP156T_Human0.83134780
153STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82667708
154KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82301685
155RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81585816
156CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81063169
157ERG_21242973_ChIP-ChIP_JURKAT_Human0.80821739
158GATA1_19941826_ChIP-Seq_K562_Human0.79669885
159GBX2_23144817_ChIP-Seq_PC3_Human0.79485723
160CDX2_22108803_ChIP-Seq_LS180_Human0.78138076
161SOX2_21211035_ChIP-Seq_LN229_Gbm0.76401292
162RARB_27405468_Chip-Seq_BRAIN_Mouse0.76366297
163GATA2_21666600_ChIP-Seq_HMVEC_Human0.74887793
164PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.72460370
165NR3C1_23031785_ChIP-Seq_PC12_Mouse0.71638924
166TCF4_22108803_ChIP-Seq_LS180_Human0.71237158
167CBP_21632823_ChIP-Seq_H3396_Human0.71213639
168GATA3_24758297_ChIP-Seq_MCF-7_Human0.70407274
169CJUN_26792858_Chip-Seq_BT549_Human0.70245049
170FOXM1_26456572_ChIP-Seq_MCF-7_Human0.69950701
171SMAD3_21741376_ChIP-Seq_HESCs_Human0.69806852
172GATA2_19941826_ChIP-Seq_K562_Human0.69287668
173FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.68698424
174FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.68387466
175TAF15_26573619_Chip-Seq_HEK293_Human0.68352158
176SALL1_21062744_ChIP-ChIP_HESCs_Human0.68245385
177TCF4_18268006_ChIP-ChIP_LS174T_Human0.68141859
178FLI1_21867929_ChIP-Seq_TH2_Mouse0.67564843
179* AR_19668381_ChIP-Seq_PC3_Human0.66356137
180P300_27058665_Chip-Seq_ZR-75-30cells_Human0.66328516
181LXR_22292898_ChIP-Seq_THP-1_Human0.65804717
182SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.65311111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.16405291
2MP0002139_abnormal_hepatobiliary_system5.65327445
3MP0005365_abnormal_bile_salt4.88705429
4MP0005085_abnormal_gallbladder_physiolo4.74858317
5MP0008875_abnormal_xenobiotic_pharmacok4.04674437
6MP0003252_abnormal_bile_duct3.31932395
7MP0003806_abnormal_nucleotide_metabolis2.99187394
8MP0003436_decreased_susceptibility_to2.91749032
9MP0009278_abnormal_bone_marrow2.91117946
10MP0010234_abnormal_vibrissa_follicle2.79471250
11MP0010329_abnormal_lipoprotein_level2.74198086
12MP0005083_abnormal_biliary_tract2.66873937
13MP0003195_calcinosis2.56891551
14MP0005332_abnormal_amino_acid2.45443395
15MP0003763_abnormal_thymus_physiology2.36809547
16MP0001666_abnormal_nutrient_absorption2.35249410
17MP0004043_abnormal_pH_regulation2.30914572
18MP0003172_abnormal_lysosome_physiology2.29422214
19MP0009840_abnormal_foam_cell2.24176987
20MP0004947_skin_inflammation2.13184804
21MP0009780_abnormal_chondrocyte_physiolo2.08954173
22MP0004019_abnormal_vitamin_homeostasis2.06058119
23MP0003705_abnormal_hypodermis_morpholog2.05939478
24MP0003724_increased_susceptibility_to2.02588232
25MP0002118_abnormal_lipid_homeostasis1.88247926
26MP0004130_abnormal_muscle_cell1.86282040
27MP0002796_impaired_skin_barrier1.86244472
28MP0001533_abnormal_skeleton_physiology1.75681097
29MP0003091_abnormal_cell_migration1.75586337
30MP0008438_abnormal_cutaneous_collagen1.74470326
31MP0001849_ear_inflammation1.72776845
32MP0003191_abnormal_cellular_cholesterol1.72366959
33MP0009643_abnormal_urine_homeostasis1.67425147
34MP0003868_abnormal_feces_composition1.60382500
35MP0008260_abnormal_autophagy1.57775819
36MP0009333_abnormal_splenocyte_physiolog1.56829618
37MP0000609_abnormal_liver_physiology1.56796307
38MP0002419_abnormal_innate_immunity1.56710995
39MP0000685_abnormal_immune_system1.52717886
40MP0005000_abnormal_immune_tolerance1.52124097
41MP0002396_abnormal_hematopoietic_system1.48257992
42MP0005387_immune_system_phenotype1.48224287
43MP0001790_abnormal_immune_system1.48224287
44MP0001545_abnormal_hematopoietic_system1.47854115
45MP0005397_hematopoietic_system_phenotyp1.47854115
46MP0001958_emphysema1.47701068
47MP0001661_extended_life_span1.45241161
48MP0002837_dystrophic_cardiac_calcinosis1.44910265
49MP0001756_abnormal_urination1.44087999
50MP0003011_delayed_dark_adaptation1.38417759
51MP0003300_gastrointestinal_ulcer1.37319486
52MP0001800_abnormal_humoral_immune1.36549971
53MP0005023_abnormal_wound_healing1.35865794
54MP0002723_abnormal_immune_serum1.35245130
55MP0001765_abnormal_ion_homeostasis1.33934745
56MP0005076_abnormal_cell_differentiation1.31336833
57MP0001819_abnormal_immune_cell1.29782243
58MP0002420_abnormal_adaptive_immunity1.29651904
59MP0003329_amyloid_beta_deposits1.29573697
60MP0001835_abnormal_antigen_presentation1.26839445
61MP0005670_abnormal_white_adipose1.25960644
62MP0005319_abnormal_enzyme/_coenzyme1.25693732
63MP0002452_abnormal_antigen_presenting1.25454632
64MP0005409_darkened_coat_color1.23889261
65MP0004185_abnormal_adipocyte_glucose1.20841987
66MP0005584_abnormal_enzyme/coenzyme_acti1.19780792
67MP0010678_abnormal_skin_adnexa1.19454168
68MP0005636_abnormal_mineral_homeostasis1.17452242
69MP0010155_abnormal_intestine_physiology1.16126737
70MP0002138_abnormal_hepatobiliary_system1.15754078
71MP0002909_abnormal_adrenal_gland1.15477662
72MP0005666_abnormal_adipose_tissue1.15195456
73MP0002933_joint_inflammation1.14766690
74MP0000604_amyloidosis1.13916003
75MP0002998_abnormal_bone_remodeling1.13495364
76MP0005551_abnormal_eye_electrophysiolog1.12211529
77MP0004233_abnormal_muscle_weight1.11436498
78MP0005025_abnormal_response_to1.10630127
79MP0000013_abnormal_adipose_tissue1.10477564
80MP0005187_abnormal_penis_morphology1.09232947
81MP0005164_abnormal_response_to1.07168389
82MP0005390_skeleton_phenotype1.06730129
83MP0000858_altered_metastatic_potential1.06528125
84MP0000716_abnormal_immune_system1.05945155
85MP0004782_abnormal_surfactant_physiolog1.05656836
86MP0002398_abnormal_bone_marrow1.05372535
87MP0002078_abnormal_glucose_homeostasis1.05075099
88MP0003279_aneurysm1.04883805
89MP0004808_abnormal_hematopoietic_stem1.03940585
90MP0004264_abnormal_extraembryonic_tissu1.03219371
91MP0008961_abnormal_basal_metabolism1.03131497
92MP0002405_respiratory_system_inflammati1.02926941
93MP0004858_abnormal_nervous_system1.02059796
94MP0000681_abnormal_thyroid_gland1.01934312
95MP0003453_abnormal_keratinocyte_physiol1.00221895
96MP0005464_abnormal_platelet_physiology1.00065928
97MP0003828_pulmonary_edema0.99824109
98MP0009764_decreased_sensitivity_to0.95844006
99MP0000703_abnormal_thymus_morphology0.95326611
100MP0001851_eye_inflammation0.92635770
101MP0002090_abnormal_vision0.92626112
102MP0002166_altered_tumor_susceptibility0.92126201
103MP0003941_abnormal_skin_development0.91965759
104MP0005621_abnormal_cell_physiology0.91404393
105MP0002269_muscular_atrophy0.90607920
106MP0002877_abnormal_melanocyte_morpholog0.90336121
107MP0010368_abnormal_lymphatic_system0.89934664
108MP0002429_abnormal_blood_cell0.89701071
109MP0002722_abnormal_immune_system0.89311894
110MP0000678_abnormal_parathyroid_gland0.88859511
111MP0009384_cardiac_valve_regurgitation0.88640061
112MP0005058_abnormal_lysosome_morphology0.88517031
113MP0005375_adipose_tissue_phenotype0.88078606
114MP0006082_CNS_inflammation0.87119185
115MP0000767_abnormal_smooth_muscle0.86836055
116MP0000747_muscle_weakness0.86611819
117MP0006054_spinal_hemorrhage0.86585171
118MP0002971_abnormal_brown_adipose0.86032943
119MP0001853_heart_inflammation0.85904452
120MP0005220_abnormal_exocrine_pancreas0.85245651
121MP0005310_abnormal_salivary_gland0.85017497
122MP0008469_abnormal_protein_level0.84788504
123MP0004381_abnormal_hair_follicle0.84695041
124MP0001270_distended_abdomen0.84356853
125MP0005647_abnormal_sex_gland0.84244463
126MP0002006_tumorigenesis0.83996528
127MP0005503_abnormal_tendon_morphology0.82815537
128MP0002970_abnormal_white_adipose0.82802435
129MP0000383_abnormal_hair_follicle0.81430922
130MP0003786_premature_aging0.81424463
131MP0005535_abnormal_body_temperature0.81391621
132MP0002136_abnormal_kidney_physiology0.80430573
133MP0010352_gastrointestinal_tract_polyps0.80143789
134MP0003656_abnormal_erythrocyte_physiolo0.79139352
135MP0000003_abnormal_adipose_tissue0.77618595
136MP0002060_abnormal_skin_morphology0.77464868
137MP0002234_abnormal_pharynx_morphology0.76744490
138MP0003566_abnormal_cell_adhesion0.76620809
139MP0004272_abnormal_basement_membrane0.76325443
140MP0008775_abnormal_heart_ventricle0.75256729
141MP0001764_abnormal_homeostasis0.73975878
142MP0002928_abnormal_bile_duct0.72443521
143MP0003690_abnormal_glial_cell0.71429244
144MP0004036_abnormal_muscle_relaxation0.70903985
145MP0000598_abnormal_liver_morphology0.69928627
146MP0001944_abnormal_pancreas_morphology0.69454490
147MP0005501_abnormal_skin_physiology0.68424485
148MP0005334_abnormal_fat_pad0.68242063
149MP0000230_abnormal_systemic_arterial0.65514030
150MP0004084_abnormal_cardiac_muscle0.63193976
151MP0002009_preneoplasia0.62223681
152MP0004215_abnormal_myocardial_fiber0.61501318
153MP0009642_abnormal_blood_homeostasis0.61009489
154MP0002254_reproductive_system_inflammat0.60815160
155MP0003950_abnormal_plasma_membrane0.60639541
156MP0002896_abnormal_bone_mineralization0.60224884
157MP0005330_cardiomyopathy0.60098271
158MP0005451_abnormal_body_composition0.59229675
159MP0003183_abnormal_peptide_metabolism0.58489134
160MP0000467_abnormal_esophagus_morphology0.57943493
161MP0005275_abnormal_skin_tensile0.57368728
162MP0005448_abnormal_energy_balance0.56247433
163MP0001216_abnormal_epidermal_layer0.55548498
164MP0003953_abnormal_hormone_level0.55440140
165MP0003959_abnormal_lean_body0.54939945
166MP0003045_fibrosis0.54382913
167MP0005408_hypopigmentation0.53414501
168MP0005266_abnormal_metabolism0.51916768

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.08999274
2Xanthomatosis (HP:0000991)4.81703206
3Deep venous thrombosis (HP:0002625)4.71379530
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.37758586
5Ketoacidosis (HP:0001993)4.37409233
6Ketosis (HP:0001946)4.24782676
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.21480169
8Hypoglycemic coma (HP:0001325)4.16755487
9Hypobetalipoproteinemia (HP:0003563)3.86320110
10Hyperglycinuria (HP:0003108)3.84894371
11Hyperglycinemia (HP:0002154)3.81977364
12Gout (HP:0001997)3.80763098
13Epidermoid cyst (HP:0200040)3.74935673
14Hyperlipoproteinemia (HP:0010980)3.74508228
15Abnormality of serine family amino acid metabolism (HP:0010894)3.67121717
16Abnormality of glycine metabolism (HP:0010895)3.67121717
17Hyperammonemia (HP:0001987)3.66498716
18Thyroid-stimulating hormone excess (HP:0002925)3.46050830
19Hypolipoproteinemia (HP:0010981)3.42703732
20Hypoalphalipoproteinemia (HP:0003233)3.40374999
21Myositis (HP:0100614)3.38647023
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.35564759
23Atrophic scars (HP:0001075)3.32646313
24Cervical subluxation (HP:0003308)3.30592184
25Abnormality of purine metabolism (HP:0004352)3.27201878
26Abnormality of fatty-acid metabolism (HP:0004359)3.22525700
27Complement deficiency (HP:0004431)3.19259614
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.15980756
29Prolonged partial thromboplastin time (HP:0003645)3.15826833
30Abnormality of the common coagulation pathway (HP:0010990)3.15412299
31Fat malabsorption (HP:0002630)3.13450919
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.06816779
33Hypoglycemic seizures (HP:0002173)3.06291920
34Entropion (HP:0000621)3.05781551
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.03645446
36Hyperinsulinemic hypoglycemia (HP:0000825)3.00966582
37Broad face (HP:0000283)2.99293357
38Abnormality of the intrinsic pathway (HP:0010989)2.96268991
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.95385422
40Dysostosis multiplex (HP:0000943)2.95227299
41Orchitis (HP:0100796)2.83901283
42Colitis (HP:0002583)2.82614535
43Pustule (HP:0200039)2.80932927
44Skin nodule (HP:0200036)2.75570848
45Abnormality of polysaccharide metabolism (HP:0011012)2.74669831
46Abnormality of glycosaminoglycan metabolism (HP:0004371)2.74669831
47Abnormality of mucopolysaccharide metabolism (HP:0011020)2.74669831
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.71289219
49Hyperglycemia (HP:0003074)2.67399291
50Abnormality of glycolipid metabolism (HP:0010969)2.63849069
51Abnormality of liposaccharide metabolism (HP:0010968)2.63849069
52Abnormality of glycosphingolipid metabolism (HP:0004343)2.63849069
53Spontaneous hematomas (HP:0007420)2.63096499
54Conjugated hyperbilirubinemia (HP:0002908)2.61727380
55Urinary glycosaminoglycan excretion (HP:0003541)2.59704513
56Mucopolysacchariduria (HP:0008155)2.59704513
57Hyperactive renin-angiotensin system (HP:0000841)2.57297656
58Myoglobinuria (HP:0002913)2.56323079
59Protrusio acetabuli (HP:0003179)2.55821746
60Abnormality of nucleobase metabolism (HP:0010932)2.53421030
61Milia (HP:0001056)2.53049409
62Premature rupture of membranes (HP:0001788)2.52924753
63Hyperuricemia (HP:0002149)2.50514593
64Increased purine levels (HP:0004368)2.50514593
65Symptomatic seizures (HP:0011145)2.45015571
66Spastic diplegia (HP:0001264)2.43045574
67Flat acetabular roof (HP:0003180)2.42238404
68Hyporeflexia of lower limbs (HP:0002600)2.42127749
69Acanthocytosis (HP:0001927)2.41559225
70Spinal cord lesions (HP:0100561)2.37743477
71Syringomyelia (HP:0003396)2.37743477
72Spondylolisthesis (HP:0003302)2.37390182
73Eczematoid dermatitis (HP:0000976)2.36180472
74Metabolic acidosis (HP:0001942)2.33924555
75Hypercholesterolemia (HP:0003124)2.31129487
76Hypokalemic alkalosis (HP:0001949)2.30818852
77Sensorimotor neuropathy (HP:0007141)2.29214511
78Biconcave vertebral bodies (HP:0004586)2.28861727
79Malnutrition (HP:0004395)2.27487060
80Optic neuritis (HP:0100653)2.26809387
81Retrobulbar optic neuritis (HP:0100654)2.26809387
82Increased circulating renin level (HP:0000848)2.24726103
83Increased cerebral lipofuscin (HP:0011813)2.24519521
84Delayed CNS myelination (HP:0002188)2.23973663
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.21492549
86Cerebral aneurysm (HP:0004944)2.18744196
87Peritonitis (HP:0002586)2.18081711
88Cerebral inclusion bodies (HP:0100314)2.18071321
89Proximal tubulopathy (HP:0000114)2.17965729
90Hyperbilirubinemia (HP:0002904)2.17589653
91Loss of speech (HP:0002371)2.17519896
92Abnormality of chloride homeostasis (HP:0011422)2.17000808
93Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.16593263
94Gastrointestinal inflammation (HP:0004386)2.15495491
95Glomerulosclerosis (HP:0000096)2.15224255
96Myocardial infarction (HP:0001658)2.14938584
97Thin bony cortex (HP:0002753)2.14608491
98Increased neuronal autofluorescent lipopigment (HP:0002074)2.11975481
99Long eyelashes (HP:0000527)2.11394558
100Abnormality of the fingertips (HP:0001211)2.11106361
101Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10157485
102Dicarboxylic aciduria (HP:0003215)2.10157485
103Abnormality of complement system (HP:0005339)2.10139723
104J-shaped sella turcica (HP:0002680)2.09951134
105Inflammation of the large intestine (HP:0002037)2.09833581
106Alkalosis (HP:0001948)2.09325820
107Steatorrhea (HP:0002570)2.08880988
108Abnormality of methionine metabolism (HP:0010901)2.08812240
109Right ventricular cardiomyopathy (HP:0011663)2.08694628
110Global brain atrophy (HP:0002283)2.05971096
111Thick nail (HP:0001805)2.04624952
112Recurrent cutaneous fungal infections (HP:0011370)2.04420479
113Chronic mucocutaneous candidiasis (HP:0002728)2.04420479
114Turricephaly (HP:0000262)2.04223906
115Vertebral compression fractures (HP:0002953)2.03509034
116Oligodontia (HP:0000677)2.02947770
117Glucose intolerance (HP:0000833)2.01680852
118Aortic aneurysm (HP:0004942)2.01651080
119Disproportionate tall stature (HP:0001519)2.01178628
120Agammaglobulinemia (HP:0004432)2.01167028
121Arterial tortuosity (HP:0005116)1.99629865
122Panhypogammaglobulinemia (HP:0003139)1.99076587
123Protuberant abdomen (HP:0001538)1.98792611
124Mitral valve prolapse (HP:0001634)1.96318515
125Elevated erythrocyte sedimentation rate (HP:0003565)1.96271052
126Abnormality of serum amino acid levels (HP:0003112)1.96124363
127Hepatocellular carcinoma (HP:0001402)1.95332209
128Abnormal gallbladder morphology (HP:0012437)1.95083501
129Aortic dissection (HP:0002647)1.94710327
130Interstitial pulmonary disease (HP:0006530)1.94277544
131Focal segmental glomerulosclerosis (HP:0000097)1.93906957
132Persistence of primary teeth (HP:0006335)1.93485936
133Joint hemorrhage (HP:0005261)1.92223690
134Cholelithiasis (HP:0001081)1.89926302
135Tachypnea (HP:0002789)1.88697693
136Mitral regurgitation (HP:0001653)1.88264027
137Upper limb amyotrophy (HP:0009129)1.87488767
138Distal upper limb amyotrophy (HP:0007149)1.87488767
139Irritability (HP:0000737)1.87180177
140Vascular calcification (HP:0004934)1.86797363
141Vascular tortuosity (HP:0004948)1.86758956
142Mediastinal lymphadenopathy (HP:0100721)1.86699854
143Back pain (HP:0003418)1.86565442
144Pulmonary embolism (HP:0002204)1.86042666
145Granulocytopenia (HP:0001913)1.84941274
146Natal tooth (HP:0000695)1.84522091
147Dilatation of the ascending aorta (HP:0005111)1.84454711
148Esophageal varix (HP:0002040)1.83854917
149Neurofibrillary tangles (HP:0002185)1.82406197
150Blue sclerae (HP:0000592)1.81537351
151Cellulitis (HP:0100658)1.81022366
152Pigmentary retinal degeneration (HP:0001146)1.80744273
153Recurrent bacterial skin infections (HP:0005406)1.80644364
154Hydroxyprolinuria (HP:0003080)1.80602289
155Abnormality of proline metabolism (HP:0010907)1.80602289
156Resting tremor (HP:0002322)1.80361910
157Fragile skin (HP:0001030)1.80318686
158Dislocated radial head (HP:0003083)1.80159764
159Retinal atrophy (HP:0001105)1.80010703
160Hyperacusis (HP:0010780)1.79930141
161Abnormal gallbladder physiology (HP:0012438)1.79672831
162Cholecystitis (HP:0001082)1.79672831
163Hematochezia (HP:0002573)1.78963470
164Recurrent fungal infections (HP:0002841)1.78486695
165Abdominal distention (HP:0003270)1.77936899
166Lymphangioma (HP:0100764)1.77753830
167Hemoptysis (HP:0002105)1.77271237
168Arterial thrombosis (HP:0004420)1.76691337
169Cardiovascular calcification (HP:0011915)1.76211994
170Abnormal hair laboratory examination (HP:0003328)1.76044711
171Neonatal onset (HP:0003623)1.75919760
172Generalized aminoaciduria (HP:0002909)1.75572717
173Aortic regurgitation (HP:0001659)1.75476353
174Abnormality of the Achilles tendon (HP:0005109)1.75272397
175Vertebral arch anomaly (HP:0008438)1.74549730
176Aneurysm (HP:0002617)1.74356295
177Abnormality of vitamin metabolism (HP:0100508)1.74056919
178Recurrent abscess formation (HP:0002722)1.74052836
179Hemorrhage of the eye (HP:0011885)1.73722049
180Poikiloderma (HP:0001029)1.73148603
181Vomiting (HP:0002013)1.72647980
182Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.72495647
183Polygenic inheritance (HP:0010982)1.72290675
184Hand muscle atrophy (HP:0009130)1.71692342
185Rickets (HP:0002748)1.71602479
186Pancreatic islet-cell hyperplasia (HP:0004510)1.71097363
187Long toe (HP:0010511)1.70249152
188Metabolic alkalosis (HP:0200114)1.69486937
189Dysmetric saccades (HP:0000641)1.69012524
190Advanced eruption of teeth (HP:0006288)1.66820162
191Autoimmune thrombocytopenia (HP:0001973)1.64168435
192Genu recurvatum (HP:0002816)1.64039191
193Viral hepatitis (HP:0006562)1.63250467
194Abnormality of oral frenula (HP:0000190)1.63148306
195Nail dystrophy (HP:0008404)1.63127187
196Coarse hair (HP:0002208)1.62659200
197Abnormality of nail color (HP:0100643)1.62539479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.24051605
2INSRR2.96217434
3ERN12.86802613
4MAP3K22.79597126
5SIK12.75827519
6MAP2K32.63894100
7BCKDK2.24032286
8MAP3K102.21973713
9PDK42.21760018
10PDK32.21760018
11RIPK12.18657536
12MAP4K12.08159663
13FGFR22.06303607
14MAP2K22.03596960
15MST1R1.98333592
16WNK41.97721756
17LATS11.96844179
18PKN21.81774818
19OXSR11.73579989
20PRKD21.69946068
21JAK31.62796931
22CDC42BPA1.61935506
23MAP3K141.61902341
24ICK1.56877502
25TRIB31.54030932
26PAK31.52253360
27TBK11.47023915
28STK391.46637509
29ADRBK21.45857647
30PTK61.44812222
31IRAK31.42637367
32FGFR41.41919150
33SCYL21.39014952
34SMG11.37163854
35MAP2K41.36692489
36TTN1.36066865
37WNK31.32669538
38MAP3K71.32014474
39KSR21.31677881
40IKBKE1.30312792
41TAOK31.28978945
42EPHA41.28890261
43NEK91.28306423
44PRPF4B1.25616138
45SGK31.25304081
46PDK21.20771300
47MET1.18125829
48ZAP701.16724503
49DAPK21.11307775
50MAP3K31.11025795
51BTK1.10368448
52MARK21.10074719
53SIK31.08409303
54FES1.05820632
55LMTK21.05269465
56CAMK1D1.05041006
57MAPK151.02421988
58RPS6KA21.01780584
59NUAK11.01138995
60FER1.01025183
61PRKAA21.00411235
62CAMK1G0.99501938
63ERBB40.99427919
64SGK20.98962435
65PDGFRA0.98951789
66SGK2230.98265497
67SGK4940.98265497
68RIPK40.97857490
69PRKCH0.97679875
70RET0.96558554
71NTRK10.95490781
72ITK0.92449625
73MAP3K40.92139802
74TGFBR20.90789621
75TNK20.90577219
76EPHA20.87260427
77MAP2K60.85121703
78NEK10.84579572
79TYRO30.84122739
80PAK40.82973846
81FGFR10.82948930
82PRKAA10.82474061
83STK380.82301629
84JAK20.80961901
85HCK0.80819953
86LRRK20.80711741
87EEF2K0.80613132
88MTOR0.80565381
89HIPK20.80382062
90WNK10.80156375
91YES10.79868742
92IKBKB0.79731500
93RPS6KL10.79442596
94RPS6KC10.79442596
95AKT30.78509158
96PHKG20.78372391
97PHKG10.78372391
98MAP3K60.77451516
99NEK60.72877103
100CDK90.72397422
101TRPM70.72195515
102JAK10.71958935
103CSF1R0.71193004
104GRK60.70615601
105PDPK10.70436753
106BRD40.70346074
107DYRK1B0.69687831
108MAP2K10.69370060
109LCK0.69317172
110BLK0.68975332
111RPS6KA60.68787759
112GSK3A0.68740819
113PTK20.67726220
114EPHB10.67105131
115CSK0.66408762
116CDK120.66067830
117MAPK70.65712550
118FGFR30.65353680
119PDGFRB0.65005412
120NTRK30.64704960
121PRKACG0.64235858
122MAP3K130.64220984
123MAP3K110.63628907
124SGK10.63494051
125MAP3K90.62562065
126PRKD30.61975738
127PRKD10.61790657
128PDK10.61516300
129IRAK10.59285854
130TAOK10.59258174
131FGR0.55580785
132SIK20.54800841
133MAPK110.54657501
134TEC0.53234524
135ADRBK10.52687813
136EGFR0.52680923
137PIM20.51707108
138EPHA30.50988114
139IRAK40.50172298
140PAK60.49796088
141CDK40.49496376
142CDK60.49139711
143MAPKAPK20.48905534
144STK38L0.48761679
145DDR20.48130441
146TXK0.47172514
147TYK20.46491935
148CHUK0.46237260
149PAK20.46208134
150STK110.45724548
151CAMKK10.45159238
152PRKCZ0.45122168
153BMX0.44316955
154STK30.44082244
155RPS6KA30.43875506
156MAP3K10.42267525
157STK100.41969770
158ERBB20.41735546
159KSR10.41664706
160TIE10.41188703

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.59835431
2Nitrogen metabolism_Homo sapiens_hsa009103.35558413
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.27869454
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.83484655
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.71552695
6Fatty acid degradation_Homo sapiens_hsa000712.61158796
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.50935610
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49598874
9Arginine biosynthesis_Homo sapiens_hsa002202.40539925
10Butanoate metabolism_Homo sapiens_hsa006502.36262495
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.35267198
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.29066383
13Propanoate metabolism_Homo sapiens_hsa006402.17261453
14Tryptophan metabolism_Homo sapiens_hsa003802.15692934
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.12708929
16Fatty acid metabolism_Homo sapiens_hsa012121.98743336
17Acute myeloid leukemia_Homo sapiens_hsa052211.91749653
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89296488
19PPAR signaling pathway_Homo sapiens_hsa033201.82172153
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81315142
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.81046253
22Bile secretion_Homo sapiens_hsa049761.80488562
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80166573
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79815490
25Sulfur metabolism_Homo sapiens_hsa009201.79442381
26Chronic myeloid leukemia_Homo sapiens_hsa052201.65715318
27Peroxisome_Homo sapiens_hsa041461.61450992
28Complement and coagulation cascades_Homo sapiens_hsa046101.57290957
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56719859
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55345748
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53861928
32Notch signaling pathway_Homo sapiens_hsa043301.52151864
33Phenylalanine metabolism_Homo sapiens_hsa003601.51854216
34Chemical carcinogenesis_Homo sapiens_hsa052041.47939865
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.47925972
36Non-small cell lung cancer_Homo sapiens_hsa052231.47434596
37Toxoplasmosis_Homo sapiens_hsa051451.46760659
38Pyruvate metabolism_Homo sapiens_hsa006201.45381426
39B cell receptor signaling pathway_Homo sapiens_hsa046621.45307110
40Lysosome_Homo sapiens_hsa041421.42892101
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.42232071
42beta-Alanine metabolism_Homo sapiens_hsa004101.41739654
43Osteoclast differentiation_Homo sapiens_hsa043801.39747363
44TNF signaling pathway_Homo sapiens_hsa046681.39165406
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38968204
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37462481
47ABC transporters_Homo sapiens_hsa020101.37170823
48Caffeine metabolism_Homo sapiens_hsa002321.34646678
49Histidine metabolism_Homo sapiens_hsa003401.34596433
50Leishmaniasis_Homo sapiens_hsa051401.33980417
51Small cell lung cancer_Homo sapiens_hsa052221.33544837
52Starch and sucrose metabolism_Homo sapiens_hsa005001.32259529
53VEGF signaling pathway_Homo sapiens_hsa043701.31479646
54Bladder cancer_Homo sapiens_hsa052191.29117331
55Selenocompound metabolism_Homo sapiens_hsa004501.28685336
56Carbon metabolism_Homo sapiens_hsa012001.27884487
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25022701
58Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22719694
59Cyanoamino acid metabolism_Homo sapiens_hsa004601.21920087
60Pancreatic cancer_Homo sapiens_hsa052121.21422895
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21418891
62Influenza A_Homo sapiens_hsa051641.20591787
63ECM-receptor interaction_Homo sapiens_hsa045121.19786276
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18810488
65Apoptosis_Homo sapiens_hsa042101.17608015
66NF-kappa B signaling pathway_Homo sapiens_hsa040641.17084586
67Steroid hormone biosynthesis_Homo sapiens_hsa001401.15523181
68Tyrosine metabolism_Homo sapiens_hsa003501.15504413
69Hepatitis B_Homo sapiens_hsa051611.13839528
70Tuberculosis_Homo sapiens_hsa051521.12205172
71Fatty acid elongation_Homo sapiens_hsa000621.12192068
72Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11545335
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11127522
74Graft-versus-host disease_Homo sapiens_hsa053321.11078857
75NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11023872
76Retinol metabolism_Homo sapiens_hsa008301.09777894
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08509019
78Biosynthesis of amino acids_Homo sapiens_hsa012301.08473452
79T cell receptor signaling pathway_Homo sapiens_hsa046601.07500833
80Sphingolipid metabolism_Homo sapiens_hsa006001.07448843
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07358410
82Fat digestion and absorption_Homo sapiens_hsa049751.06034114
83Autoimmune thyroid disease_Homo sapiens_hsa053201.05487060
84Hepatitis C_Homo sapiens_hsa051601.04025249
85Lysine degradation_Homo sapiens_hsa003101.03865043
86Leukocyte transendothelial migration_Homo sapiens_hsa046701.03135211
87Primary immunodeficiency_Homo sapiens_hsa053401.00368185
88Allograft rejection_Homo sapiens_hsa053301.00053075
89Choline metabolism in cancer_Homo sapiens_hsa052310.98981757
90Focal adhesion_Homo sapiens_hsa045100.97557304
91Prolactin signaling pathway_Homo sapiens_hsa049170.97360300
92ErbB signaling pathway_Homo sapiens_hsa040120.97071579
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.96858130
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95265587
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93244923
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.93033478
97Glycerolipid metabolism_Homo sapiens_hsa005610.92748558
98Viral myocarditis_Homo sapiens_hsa054160.91684431
99Malaria_Homo sapiens_hsa051440.90661926
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.89145324
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88802460
102Herpes simplex infection_Homo sapiens_hsa051680.87822739
103Measles_Homo sapiens_hsa051620.87333162
104Endometrial cancer_Homo sapiens_hsa052130.86637930
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86363984
106GnRH signaling pathway_Homo sapiens_hsa049120.85605193
107MicroRNAs in cancer_Homo sapiens_hsa052060.84344447
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84292218
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83406171
110Fatty acid biosynthesis_Homo sapiens_hsa000610.82461762
111Proteoglycans in cancer_Homo sapiens_hsa052050.81276422
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79494371
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.79464832
114Vitamin digestion and absorption_Homo sapiens_hsa049770.79016676
115Antigen processing and presentation_Homo sapiens_hsa046120.78840976
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.78568711
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.76882638
118Amoebiasis_Homo sapiens_hsa051460.76765001
119Dorso-ventral axis formation_Homo sapiens_hsa043200.76755386
120Platelet activation_Homo sapiens_hsa046110.76047205
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.73738653
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72000161
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71816688
124Renal cell carcinoma_Homo sapiens_hsa052110.71204601
125Asthma_Homo sapiens_hsa053100.71157408
126Legionellosis_Homo sapiens_hsa051340.70634978
127Type II diabetes mellitus_Homo sapiens_hsa049300.70550868
128Chemokine signaling pathway_Homo sapiens_hsa040620.70488397
129Pertussis_Homo sapiens_hsa051330.70260495
130Insulin resistance_Homo sapiens_hsa049310.69355007
131Estrogen signaling pathway_Homo sapiens_hsa049150.68230170
132Glucagon signaling pathway_Homo sapiens_hsa049220.66886941
133HTLV-I infection_Homo sapiens_hsa051660.66711939
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65870891
135Endocytosis_Homo sapiens_hsa041440.64252046
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64134926
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63533626
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61971548
139Hematopoietic cell lineage_Homo sapiens_hsa046400.61339541
140Pathways in cancer_Homo sapiens_hsa052000.61118069
141Glioma_Homo sapiens_hsa052140.60254402
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59818903
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.59623212
144Prostate cancer_Homo sapiens_hsa052150.58627764
145Insulin secretion_Homo sapiens_hsa049110.58555341
146Thyroid cancer_Homo sapiens_hsa052160.58131956
147FoxO signaling pathway_Homo sapiens_hsa040680.57965073
148p53 signaling pathway_Homo sapiens_hsa041150.57888646
149Folate biosynthesis_Homo sapiens_hsa007900.55722237
150Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55668655
151Arginine and proline metabolism_Homo sapiens_hsa003300.53762706
152Colorectal cancer_Homo sapiens_hsa052100.52492664
153Staphylococcus aureus infection_Homo sapiens_hsa051500.51190059
154Fructose and mannose metabolism_Homo sapiens_hsa000510.50389506
155Thyroid hormone synthesis_Homo sapiens_hsa049180.49083881
156Glutathione metabolism_Homo sapiens_hsa004800.46353197
157Gastric acid secretion_Homo sapiens_hsa049710.45427038
158Pentose phosphate pathway_Homo sapiens_hsa000300.43244852
159Sulfur relay system_Homo sapiens_hsa041220.40681146
160AMPK signaling pathway_Homo sapiens_hsa041520.40360604
161Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39507590
162Steroid biosynthesis_Homo sapiens_hsa001000.37866610
163Mineral absorption_Homo sapiens_hsa049780.37172810
164Renin secretion_Homo sapiens_hsa049240.35249112
165Renin-angiotensin system_Homo sapiens_hsa046140.31182246
166Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30539428
167Pancreatic secretion_Homo sapiens_hsa049720.30358199
168Phototransduction_Homo sapiens_hsa047440.28913582
169Galactose metabolism_Homo sapiens_hsa000520.27759911
170mTOR signaling pathway_Homo sapiens_hsa041500.27713424
171Glycerophospholipid metabolism_Homo sapiens_hsa005640.27663131
172Insulin signaling pathway_Homo sapiens_hsa049100.27422361
173Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26888543
174Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25659827
175Protein digestion and absorption_Homo sapiens_hsa049740.25188522
176Metabolic pathways_Homo sapiens_hsa011000.24681548
177alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23535076
178Inositol phosphate metabolism_Homo sapiens_hsa005620.23241952
179Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23213934
180Central carbon metabolism in cancer_Homo sapiens_hsa052300.23056208
181Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20349549
182Salivary secretion_Homo sapiens_hsa049700.16954425
183Long-term potentiation_Homo sapiens_hsa047200.15711724
184GABAergic synapse_Homo sapiens_hsa047270.15013734
185Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14786125
186Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.14722591

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