PIGH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.26856610
2myelination (GO:0042552)7.45908080
3ensheathment of neurons (GO:0007272)7.45151808
4axon ensheathment (GO:0008366)7.45151808
5long-chain fatty acid biosynthetic process (GO:0042759)6.34392142
6negative regulation of neurotransmitter secretion (GO:0046929)5.62916826
7myelin maintenance (GO:0043217)5.46183181
8oligodendrocyte differentiation (GO:0048709)5.18648388
9negative regulation of neurotransmitter transport (GO:0051589)5.00103051
10glycerophospholipid catabolic process (GO:0046475)4.73233345
11eye photoreceptor cell differentiation (GO:0001754)4.68113438
12photoreceptor cell differentiation (GO:0046530)4.68113438
13apical protein localization (GO:0045176)4.63085902
14asymmetric protein localization (GO:0008105)4.62587511
15cholesterol biosynthetic process (GO:0006695)4.61049339
16astrocyte development (GO:0014002)4.60864186
17amyloid precursor protein metabolic process (GO:0042982)4.35154356
18piRNA metabolic process (GO:0034587)4.27158341
19regulation of collateral sprouting (GO:0048670)4.26786257
20negative regulation of protein localization to cell surface (GO:2000009)4.26471603
21protein complex biogenesis (GO:0070271)4.24885670
22mitochondrial respiratory chain complex I assembly (GO:0032981)4.24673817
23NADH dehydrogenase complex assembly (GO:0010257)4.24673817
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.24673817
25presynaptic membrane organization (GO:0097090)4.24186332
26nucleotide transmembrane transport (GO:1901679)4.21476377
27sterol biosynthetic process (GO:0016126)4.20832898
28positive regulation of oligodendrocyte differentiation (GO:0048714)4.18672708
29cellular ketone body metabolic process (GO:0046950)4.17890707
30presynaptic membrane assembly (GO:0097105)4.12268497
31creatine metabolic process (GO:0006600)4.09156448
32magnesium ion transport (GO:0015693)3.97588165
33ubiquinone biosynthetic process (GO:0006744)3.96046677
34establishment of mitochondrion localization (GO:0051654)3.94732278
35mitochondrial respiratory chain complex assembly (GO:0033108)3.94073716
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.87839844
37respiratory chain complex IV assembly (GO:0008535)3.85306189
38ketone body metabolic process (GO:1902224)3.83921810
39DNA deamination (GO:0045006)3.77362698
40ubiquinone metabolic process (GO:0006743)3.75011735
41tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.73307327
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.73307327
43positive regulation of cellular amine metabolic process (GO:0033240)3.70423823
44substantia nigra development (GO:0021762)3.68956251
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.68372929
46long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.67161341
47proteasome assembly (GO:0043248)3.64883121
48amyloid precursor protein catabolic process (GO:0042987)3.63848888
49response to redox state (GO:0051775)3.58280583
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.55196989
51negative regulation of execution phase of apoptosis (GO:1900118)3.55096052
52iron-sulfur cluster assembly (GO:0016226)3.54501719
53metallo-sulfur cluster assembly (GO:0031163)3.54501719
54behavioral response to nicotine (GO:0035095)3.53539268
55glycosylceramide metabolic process (GO:0006677)3.53167188
56isoprenoid biosynthetic process (GO:0008299)3.52816896
57positive regulation of prostaglandin secretion (GO:0032308)3.50688697
58leukocyte migration involved in inflammatory response (GO:0002523)3.49534672
59cerebral cortex radially oriented cell migration (GO:0021799)3.48797475
60limb bud formation (GO:0060174)3.47529163
61adhesion of symbiont to host cell (GO:0044650)3.45245526
62virion attachment to host cell (GO:0019062)3.45245526
63* GPI anchor biosynthetic process (GO:0006506)3.45078983
64long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.41581579
65response to methylmercury (GO:0051597)3.39192065
66organ growth (GO:0035265)3.36902517
67positive regulation of action potential (GO:0045760)3.36381685
68cytochrome complex assembly (GO:0017004)3.35492505
69S-adenosylmethionine metabolic process (GO:0046500)3.33620128
70negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.31751610
71response to lipoprotein particle (GO:0055094)3.31232142
72mannosylation (GO:0097502)3.30845672
73glial cell development (GO:0021782)3.29154041
74L-methionine salvage (GO:0071267)3.29032192
75L-methionine biosynthetic process (GO:0071265)3.29032192
76amino acid salvage (GO:0043102)3.29032192
77energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28137857
78ATP synthesis coupled proton transport (GO:0015986)3.28137857
79* GPI anchor metabolic process (GO:0006505)3.27528371
80axon development (GO:0061564)3.21480287
81positive regulation of glial cell differentiation (GO:0045687)3.19580457
82quinone biosynthetic process (GO:1901663)3.19579412
83protein-cofactor linkage (GO:0018065)3.19390647
84protein palmitoylation (GO:0018345)3.18635165
85myelination in peripheral nervous system (GO:0022011)3.15472155
86peripheral nervous system axon ensheathment (GO:0032292)3.15472155
87electron transport chain (GO:0022900)3.13816540
88respiratory electron transport chain (GO:0022904)3.11861221
89import into cell (GO:0098657)3.11629333
90platelet dense granule organization (GO:0060155)3.11428232
91indolalkylamine metabolic process (GO:0006586)3.10328913
92regulation of somitogenesis (GO:0014807)3.07276884
93protein neddylation (GO:0045116)3.06929359
94negative regulation of JUN kinase activity (GO:0043508)3.05279190
95L-amino acid import (GO:0043092)3.05120973
96positive regulation of gliogenesis (GO:0014015)3.04581301
97water-soluble vitamin biosynthetic process (GO:0042364)3.04273265
98fatty-acyl-CoA biosynthetic process (GO:0046949)3.01537419
99nucleotide transport (GO:0006862)3.01241873
100DNA methylation involved in gamete generation (GO:0043046)2.98700177
101nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98183731
102peptidyl-tyrosine autophosphorylation (GO:0038083)2.98144061
103cullin deneddylation (GO:0010388)2.97817052
104interleukin-6-mediated signaling pathway (GO:0070102)2.96169263
105enteric nervous system development (GO:0048484)2.93602662
106exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91811768
107microtubule polymerization or depolymerization (GO:0031109)2.91057490
108adenosine metabolic process (GO:0046085)2.91052268
109pseudouridine synthesis (GO:0001522)2.90507385
110L-fucose catabolic process (GO:0042355)2.90355813
111fucose catabolic process (GO:0019317)2.90355813
112L-fucose metabolic process (GO:0042354)2.90355813
113very long-chain fatty acid metabolic process (GO:0000038)2.90131889
114cranial nerve development (GO:0021545)2.89800151
115protein deneddylation (GO:0000338)2.87732168
116regulation of lipoprotein metabolic process (GO:0050746)2.87509952
117male meiosis I (GO:0007141)2.87145771
118negative regulation of chemokine production (GO:0032682)2.86568969
119peripheral nervous system development (GO:0007422)2.83001667
120ear development (GO:0043583)2.82740808
121negative regulation of macroautophagy (GO:0016242)2.80522743
122negative regulation of axonogenesis (GO:0050771)2.79928436
123fatty-acyl-CoA metabolic process (GO:0035337)2.79916220
124membrane raft organization (GO:0031579)2.79891018
125* preassembly of GPI anchor in ER membrane (GO:0016254)2.79873341
126regulation of meiosis I (GO:0060631)2.79298671
127response to lead ion (GO:0010288)2.75972918
128epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.73737037
129negative regulation of telomere maintenance (GO:0032205)2.73096861
130glial cell differentiation (GO:0010001)2.71746947
131histone H2B ubiquitination (GO:0033523)2.70700517
132regulation of feeding behavior (GO:0060259)2.70343452
133proton transport (GO:0015992)2.69904022
134intracellular pH reduction (GO:0051452)2.69767999
135establishment of protein localization to mitochondrial membrane (GO:0090151)2.68758539
136positive regulation of fatty acid transport (GO:2000193)2.68389750
137positive regulation of mitochondrial fission (GO:0090141)2.67125380
138hydrogen ion transmembrane transport (GO:1902600)2.67040161
139hydrogen transport (GO:0006818)2.66085835
140peptidyl-histidine modification (GO:0018202)2.66059513
141regulation of mitochondrial translation (GO:0070129)2.63553921
142lateral sprouting from an epithelium (GO:0060601)2.62751624
143RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62246257
144dopamine biosynthetic process (GO:0042416)2.60978133
145regulation of cilium movement (GO:0003352)2.60810835
146peptidyl-cysteine modification (GO:0018198)2.60193378
147tRNA processing (GO:0008033)2.59766992
148positive regulation of cell fate commitment (GO:0010455)2.59686192
149L-serine transport (GO:0015825)2.58601493
150regulation of glucokinase activity (GO:0033131)2.58471109
151regulation of hexokinase activity (GO:1903299)2.58471109
152adult walking behavior (GO:0007628)2.57576946
153methionine biosynthetic process (GO:0009086)2.57525585
154detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.57341504
155detection of light stimulus involved in visual perception (GO:0050908)2.56475525
156detection of light stimulus involved in sensory perception (GO:0050962)2.56475525
157positive regulation of icosanoid secretion (GO:0032305)2.55290605
158regulation of prostaglandin secretion (GO:0032306)2.54630289
159energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.54136191
160ATP hydrolysis coupled proton transport (GO:0015991)2.54136191
161protein polyglutamylation (GO:0018095)2.53400977
162anterograde synaptic vesicle transport (GO:0048490)2.53215105
163axoneme assembly (GO:0035082)2.53095489
164negative regulation of transcription by competitive promoter binding (GO:0010944)2.52444688
165regulation of pigment cell differentiation (GO:0050932)2.52333941
166polyol transport (GO:0015791)2.51881970
167negative regulation of myoblast differentiation (GO:0045662)2.51672927
168neural nucleus development (GO:0048857)2.51468107
169pH reduction (GO:0045851)2.50979398
170oligodendrocyte development (GO:0014003)2.49616798
171transcription elongation from RNA polymerase III promoter (GO:0006385)2.49453453
172termination of RNA polymerase III transcription (GO:0006386)2.49453453
173indole-containing compound catabolic process (GO:0042436)2.47282883
174indolalkylamine catabolic process (GO:0046218)2.47282883
175tryptophan catabolic process (GO:0006569)2.47282883
176transmission of nerve impulse (GO:0019226)2.46925097
177reciprocal meiotic recombination (GO:0007131)2.46907643
178reciprocal DNA recombination (GO:0035825)2.46907643
179chaperone-mediated protein transport (GO:0072321)2.41286560
180response to pheromone (GO:0019236)2.40342296
181positive regulation of meiosis (GO:0045836)2.38912208
182base-excision repair, AP site formation (GO:0006285)2.36953996
183behavioral response to ethanol (GO:0048149)2.36537731
184DNA double-strand break processing (GO:0000729)2.36488291
185epithelial cilium movement (GO:0003351)2.36060336
186purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.34690048
187pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.34688496
188negative regulation of transcription regulatory region DNA binding (GO:2000678)2.32423803
189amine catabolic process (GO:0009310)2.32307673
190cellular biogenic amine catabolic process (GO:0042402)2.32307673
191male meiosis (GO:0007140)2.31340023
192deoxyribose phosphate biosynthetic process (GO:0046385)2.30535018
193axon ensheathment in central nervous system (GO:0032291)12.2073434
194central nervous system myelination (GO:0022010)12.2073434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.93466538
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.72205663
3ZNF274_21170338_ChIP-Seq_K562_Hela3.33903789
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.32568938
5TAF15_26573619_Chip-Seq_HEK293_Human3.22991706
6GBX2_23144817_ChIP-Seq_PC3_Human3.21282681
7SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.97568764
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94574035
9VDR_22108803_ChIP-Seq_LS180_Human2.66655593
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.63567078
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49265107
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45195268
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44894268
14VDR_23849224_ChIP-Seq_CD4+_Human2.40162249
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38658615
16IRF1_19129219_ChIP-ChIP_H3396_Human2.30828113
17OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.22162319
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.16949775
19ER_23166858_ChIP-Seq_MCF-7_Human2.15770497
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09012144
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08443765
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.05637530
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01823484
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.99717361
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96603315
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.87886498
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85094585
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84618386
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82804064
30ELK1_19687146_ChIP-ChIP_HELA_Human1.78528999
31FUS_26573619_Chip-Seq_HEK293_Human1.75896301
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.73783384
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73638647
34FOXP3_21729870_ChIP-Seq_TREG_Human1.70713028
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69594769
36* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69046875
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66809821
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65576050
39TP53_22573176_ChIP-Seq_HFKS_Human1.65159783
40MYC_18940864_ChIP-ChIP_HL60_Human1.63393642
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.63126412
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.57510692
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56878371
44TAL1_26923725_Chip-Seq_HPCs_Mouse1.55447895
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55284754
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53913100
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53558439
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52719525
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51563954
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50896610
51STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.50134074
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.49548253
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48175886
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48154685
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47107518
56* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46105623
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43997376
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43817883
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.43465258
60CBP_20019798_ChIP-Seq_JUKART_Human1.43030275
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43030275
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41584082
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41414947
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41108206
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40978925
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38329164
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37868605
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.37520619
69P300_18555785_Chip-Seq_ESCs_Mouse1.37516285
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.37358146
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37358146
72LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37355051
73P300_19829295_ChIP-Seq_ESCs_Human1.37329267
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36992596
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36346183
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.34609645
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.33031644
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32490112
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31594086
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31215003
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31125619
82NCOR_22424771_ChIP-Seq_293T_Human1.31069170
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30573294
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29991561
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28563179
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27819867
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27668078
88EZH2_22144423_ChIP-Seq_EOC_Human1.27069028
89SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.26658763
90MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25843348
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25788934
92EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24806083
93RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24550065
94EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24550065
95RNF2_27304074_Chip-Seq_NSC_Mouse1.24426001
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24333299
97* GABP_19822575_ChIP-Seq_HepG2_Human1.24055459
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23349917
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.23089231
100FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22957635
101SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21892647
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20670158
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20595598
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20192409
105STAT3_18555785_Chip-Seq_ESCs_Mouse1.20041268
106LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19491035
107EWS_26573619_Chip-Seq_HEK293_Human1.18750599
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18714225
109EOMES_21245162_ChIP-Seq_HESCs_Human1.18235376
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16624922
111AR_20517297_ChIP-Seq_VCAP_Human1.15373597
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15021396
113RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14921317
114EZH2_27294783_Chip-Seq_NPCs_Mouse1.14098527
115SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13471822
116KLF4_18555785_Chip-Seq_ESCs_Mouse1.13357924
117HTT_18923047_ChIP-ChIP_STHdh_Human1.12739508
118AR_21572438_ChIP-Seq_LNCaP_Human1.12623125
119NFE2_27457419_Chip-Seq_LIVER_Mouse1.12467673
120RNF2_27304074_Chip-Seq_ESCs_Mouse1.12062843
121FLI1_27457419_Chip-Seq_LIVER_Mouse1.10629472
122HOXB7_26014856_ChIP-Seq_BT474_Human1.09795277
123SOX2_18555785_Chip-Seq_ESCs_Mouse1.09634470
124SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09510681
125P53_22387025_ChIP-Seq_ESCs_Mouse1.08843749
126DCP1A_22483619_ChIP-Seq_HELA_Human1.08358879
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.07959025
128* GATA3_26560356_Chip-Seq_TH2_Human1.07303402
129CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07026803
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06608399
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05693827
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05669571
133NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05669571
134IGF1R_20145208_ChIP-Seq_DFB_Human1.05159219
135FOXH1_21741376_ChIP-Seq_EPCs_Human1.04569678
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04031137
137PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03993712
138TCF4_23295773_ChIP-Seq_U87_Human1.03684086
139AR_25329375_ChIP-Seq_VCAP_Human1.03534641
140NANOG_19829295_ChIP-Seq_ESCs_Human1.03115070
141SOX2_19829295_ChIP-Seq_ESCs_Human1.03115070
142TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02766378
143OCT4_18555785_Chip-Seq_ESCs_Mouse1.02595937
144FLI1_21867929_ChIP-Seq_TH2_Mouse1.01250234
145LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01145995
146NMYC_18555785_Chip-Seq_ESCs_Mouse1.00344238
147FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99717658
148STAT3_23295773_ChIP-Seq_U87_Human0.99135170
149SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99032937
150KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98999586
151KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98999586
152KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98999586
153BCAT_22108803_ChIP-Seq_LS180_Human0.98885763
154HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98708530
155AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98668092
156TCF4_22108803_ChIP-Seq_LS180_Human0.98020681
157CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98010188
158GATA3_21878914_ChIP-Seq_MCF-7_Human0.97762447
159JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97472701
160ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97178848
161CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97034174
162SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96941617
163* SMAD4_21799915_ChIP-Seq_A2780_Human0.96877937
164SOX2_16153702_ChIP-ChIP_HESCs_Human0.96784584
165CRX_20693478_ChIP-Seq_RETINA_Mouse0.94901856
166FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94660801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.78619454
2MP0003950_abnormal_plasma_membrane3.75312837
3MP0002163_abnormal_gland_morphology3.46887024
4MP0003136_yellow_coat_color3.43513466
5MP0003195_calcinosis3.22708536
6MP0005409_darkened_coat_color3.18349476
7MP0003690_abnormal_glial_cell3.17622498
8MP0004742_abnormal_vestibular_system2.95762984
9MP0008877_abnormal_DNA_methylation2.92863109
10MP0004147_increased_porphyrin_level2.91793642
11MP0005171_absent_coat_pigmentation2.71731687
12MP0003880_abnormal_central_pattern2.66975403
13MP0000566_synostosis2.66155215
14MP0004270_analgesia2.64678823
15MP0001905_abnormal_dopamine_level2.54017461
16MP0001485_abnormal_pinna_reflex2.52304342
17MP0002102_abnormal_ear_morphology2.48036547
18MP0004885_abnormal_endolymph2.47249363
19MP0001529_abnormal_vocalization2.43715673
20MP0003329_amyloid_beta_deposits2.27044114
21MP0002138_abnormal_hepatobiliary_system2.26337774
22MP0000383_abnormal_hair_follicle2.25932229
23MP0003634_abnormal_glial_cell2.22812882
24MP0000462_abnormal_digestive_system2.17536945
25MP0004381_abnormal_hair_follicle2.16092375
26MP0004142_abnormal_muscle_tone2.05613982
27MP0002837_dystrophic_cardiac_calcinosis2.03768703
28MP0005084_abnormal_gallbladder_morpholo2.03354115
29MP0002272_abnormal_nervous_system1.97922034
30MP0002876_abnormal_thyroid_physiology1.94833181
31MP0010678_abnormal_skin_adnexa1.91231749
32MP0001486_abnormal_startle_reflex1.89289133
33MP0008058_abnormal_DNA_repair1.87223035
34MP0003632_abnormal_nervous_system1.85546099
35MP0005410_abnormal_fertilization1.84044147
36MP0008872_abnormal_physiological_respon1.83127400
37MP0000778_abnormal_nervous_system1.79587108
38MP0001346_abnormal_lacrimal_gland1.79241258
39MP0008260_abnormal_autophagy1.78491086
40MP0002229_neurodegeneration1.69450504
41MP0008875_abnormal_xenobiotic_pharmacok1.67281711
42MP0004043_abnormal_pH_regulation1.66766853
43MP0001968_abnormal_touch/_nociception1.63805212
44MP0002928_abnormal_bile_duct1.61106091
45MP0006036_abnormal_mitochondrial_physio1.58357967
46MP0010386_abnormal_urinary_bladder1.55839866
47MP0001963_abnormal_hearing_physiology1.55649418
48MP0003646_muscle_fatigue1.55013274
49MP0003787_abnormal_imprinting1.53812224
50MP0006035_abnormal_mitochondrial_morpho1.49180134
51MP0001764_abnormal_homeostasis1.47587582
52MP0005174_abnormal_tail_pigmentation1.43741805
53MP0003186_abnormal_redox_activity1.42707380
54MP0005058_abnormal_lysosome_morphology1.42463658
55MP0002064_seizures1.41664916
56MP0003252_abnormal_bile_duct1.37990381
57MP0002736_abnormal_nociception_after1.35927354
58MP0005365_abnormal_bile_salt1.34348560
59MP0005551_abnormal_eye_electrophysiolog1.32886881
60MP0008995_early_reproductive_senescence1.32646905
61MP0005389_reproductive_system_phenotype1.30553393
62MP0000372_irregular_coat_pigmentation1.29897529
63MP0003011_delayed_dark_adaptation1.29521060
64MP0003938_abnormal_ear_development1.28243991
65MP0003937_abnormal_limbs/digits/tail_de1.28092603
66MP0001919_abnormal_reproductive_system1.27494961
67MP0005085_abnormal_gallbladder_physiolo1.26550706
68MP0004134_abnormal_chest_morphology1.24347044
69MP0002638_abnormal_pupillary_reflex1.23552214
70MP0008057_abnormal_DNA_replication1.22159889
71MP0003806_abnormal_nucleotide_metabolis1.21373731
72MP0006276_abnormal_autonomic_nervous1.19666054
73MP0001851_eye_inflammation1.19541094
74MP0003631_nervous_system_phenotype1.19379195
75MP0002938_white_spotting1.14861530
76MP0002160_abnormal_reproductive_system1.14588872
77MP0005220_abnormal_exocrine_pancreas1.14340211
78MP0001188_hyperpigmentation1.14304253
79MP0002734_abnormal_mechanical_nocicepti1.13761685
80MP0000015_abnormal_ear_pigmentation1.13120002
81MP0002095_abnormal_skin_pigmentation1.12258255
82MP0001501_abnormal_sleep_pattern1.11701005
83MP0005332_abnormal_amino_acid1.11167479
84MP0002752_abnormal_somatic_nervous1.10975069
85MP0005636_abnormal_mineral_homeostasis1.10585186
86MP0002882_abnormal_neuron_morphology1.10417754
87MP0000026_abnormal_inner_ear1.10133008
88MP0000604_amyloidosis1.07945079
89MP0009379_abnormal_foot_pigmentation1.06673731
90MP0002132_abnormal_respiratory_system1.06656711
91MP0004145_abnormal_muscle_electrophysio1.05229772
92MP0001984_abnormal_olfaction1.05208926
93MP0005075_abnormal_melanosome_morpholog1.02899220
94MP0000647_abnormal_sebaceous_gland1.02850078
95MP0006082_CNS_inflammation1.02107579
96MP0001299_abnormal_eye_distance/1.01859801
97MP0000467_abnormal_esophagus_morphology1.01401945
98MP0008789_abnormal_olfactory_epithelium1.01128709
99MP0000465_gastrointestinal_hemorrhage1.00987509
100MP0001929_abnormal_gametogenesis0.99599237
101MP0003786_premature_aging0.99576810
102MP0005195_abnormal_posterior_eye0.97819692
103MP0002909_abnormal_adrenal_gland0.97804043
104MP0000955_abnormal_spinal_cord0.97093111
105MP0005408_hypopigmentation0.96112179
106MP0005423_abnormal_somatic_nervous0.95971712
107MP0004133_heterotaxia0.95797816
108MP0000569_abnormal_digit_pigmentation0.95506305
109MP0002822_catalepsy0.94213367
110MP0000762_abnormal_tongue_morphology0.93990985
111MP0001440_abnormal_grooming_behavior0.93375460
112MP0002210_abnormal_sex_determination0.90732013
113MP0003283_abnormal_digestive_organ0.90453308
114MP0008569_lethality_at_weaning0.89550708
115MP0009764_decreased_sensitivity_to0.89444873
116MP0002557_abnormal_social/conspecific_i0.88730786
117MP0002066_abnormal_motor_capabilities/c0.87242642
118MP0005645_abnormal_hypothalamus_physiol0.85986684
119MP0002234_abnormal_pharynx_morphology0.85904891
120MP0003698_abnormal_male_reproductive0.85577431
121MP0009697_abnormal_copulation0.85368578
122MP0001348_abnormal_lacrimal_gland0.84989966
123MP0010329_abnormal_lipoprotein_level0.84617764
124MP0001986_abnormal_taste_sensitivity0.83189427
125MP0005379_endocrine/exocrine_gland_phen0.82913962
126MP0000653_abnormal_sex_gland0.81649577
127MP0006072_abnormal_retinal_apoptosis0.80604214
128MP0003633_abnormal_nervous_system0.79780102
129MP0009046_muscle_twitch0.78172390
130MP0005451_abnormal_body_composition0.77574199
131MP0009250_abnormal_appendicular_skeleto0.77062936
132MP0009745_abnormal_behavioral_response0.76639681
133MP0005253_abnormal_eye_physiology0.76480548
134MP0005167_abnormal_blood-brain_barrier0.76271678
135MP0000427_abnormal_hair_cycle0.74376342
136MP0000639_abnormal_adrenal_gland0.74286198
137MP0002733_abnormal_thermal_nociception0.74250978
138MP0005646_abnormal_pituitary_gland0.73731516
139MP0002067_abnormal_sensory_capabilities0.73633112
140MP0001502_abnormal_circadian_rhythm0.73355472
141MP0003693_abnormal_embryo_hatching0.72722654
142MP0004924_abnormal_behavior0.71936164
143MP0005386_behavior/neurological_phenoty0.71936164
144MP0001145_abnormal_male_reproductive0.71737443
145MP0000631_abnormal_neuroendocrine_gland0.71703028
146MP0000613_abnormal_salivary_gland0.69182306
147MP0001727_abnormal_embryo_implantation0.68933484
148MP0001970_abnormal_pain_threshold0.68412873
149MP0003718_maternal_effect0.67197757
150MP0006292_abnormal_olfactory_placode0.66569537
151MP0001661_extended_life_span0.66133287
152MP0002572_abnormal_emotion/affect_behav0.65657077
153MP0002277_abnormal_respiratory_mucosa0.65108647
154MP0005310_abnormal_salivary_gland0.63326101
155MP0002295_abnormal_pulmonary_circulatio0.63322040
156MP0000537_abnormal_urethra_morphology0.61896673
157MP0000579_abnormal_nail_morphology0.61520210
158MP0002098_abnormal_vibrissa_morphology0.60469773
159MP0001664_abnormal_digestion0.57868711
160MP0000747_muscle_weakness0.57366523
161MP0002152_abnormal_brain_morphology0.57201257
162MP0001177_atelectasis0.56539043
163MP0001340_abnormal_eyelid_morphology0.54613865

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.79882847
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.79882847
3Neurofibrillary tangles (HP:0002185)5.30503442
4Parakeratosis (HP:0001036)5.25342358
5Abnormality of the corticospinal tract (HP:0002492)4.55818067
6Peripheral hypomyelination (HP:0007182)4.15805206
7Cerebral hypomyelination (HP:0006808)4.05697731
8Sensory axonal neuropathy (HP:0003390)3.99883088
9Acute necrotizing encephalopathy (HP:0006965)3.77630139
10Split foot (HP:0001839)3.76243918
11Hepatocellular necrosis (HP:0001404)3.67243047
12Mitochondrial inheritance (HP:0001427)3.61140142
13Increased CSF lactate (HP:0002490)3.56850748
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.51431613
15Hepatic necrosis (HP:0002605)3.49986257
16Abnormal mitochondria in muscle tissue (HP:0008316)3.49887370
17Acute encephalopathy (HP:0006846)3.43468146
18Pancreatic cysts (HP:0001737)3.35591614
19Alacrima (HP:0000522)3.31200639
20Patchy hypopigmentation of hair (HP:0011365)3.28188520
21Molar tooth sign on MRI (HP:0002419)3.26837165
22Abnormality of midbrain morphology (HP:0002418)3.26837165
23Cerebral inclusion bodies (HP:0100314)3.26230592
24Progressive macrocephaly (HP:0004481)3.24153231
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.24065323
26White forelock (HP:0002211)3.21696615
27Onion bulb formation (HP:0003383)3.18572123
28Anteriorly placed anus (HP:0001545)3.12723800
29Abnormality of alanine metabolism (HP:0010916)3.02022119
30Hyperalaninemia (HP:0003348)3.02022119
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.02022119
32Premature skin wrinkling (HP:0100678)2.95291205
33Type II lissencephaly (HP:0007260)2.92474461
34Absent septum pellucidum (HP:0001331)2.91949732
35Spastic gait (HP:0002064)2.90794910
36Abnormality of the renal cortex (HP:0011035)2.88782076
37Medial flaring of the eyebrow (HP:0010747)2.84190964
38Abnormality of the phalanges of the 2nd finger (HP:0009541)2.78993159
39Abnormal auditory evoked potentials (HP:0006958)2.77686429
40Morphological abnormality of the inner ear (HP:0011390)2.74918630
41CNS hypomyelination (HP:0003429)2.74637330
42Leukodystrophy (HP:0002415)2.70629390
43Renal cortical cysts (HP:0000803)2.69503591
44Partial duplication of thumb phalanx (HP:0009944)2.66206216
45Increased serum lactate (HP:0002151)2.65558212
46Increased serum pyruvate (HP:0003542)2.65371986
47Abnormality of glycolysis (HP:0004366)2.65371986
48Prolonged neonatal jaundice (HP:0006579)2.63873030
49Autoamputation (HP:0001218)2.62916289
50Decreased lacrimation (HP:0000633)2.62829785
51Stenosis of the external auditory canal (HP:0000402)2.61522610
52Retinal dysplasia (HP:0007973)2.60373156
53Congenital ichthyosiform erythroderma (HP:0007431)2.59722818
54Pancreatic fibrosis (HP:0100732)2.58316385
55Abnormality of the septum pellucidum (HP:0007375)2.58293363
56Thickened helices (HP:0000391)2.57032115
57True hermaphroditism (HP:0010459)2.56843449
58Cerebral edema (HP:0002181)2.54989991
59Nephronophthisis (HP:0000090)2.53715551
60Lipid accumulation in hepatocytes (HP:0006561)2.52651064
61Congenital stationary night blindness (HP:0007642)2.51421778
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51063335
63Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51063335
64Stridor (HP:0010307)2.50119353
65Hepatosplenomegaly (HP:0001433)2.49669259
66Lactic acidosis (HP:0003128)2.49172272
67Segmental peripheral demyelination/remyelination (HP:0003481)2.49153325
68Abnormality of the renal collecting system (HP:0004742)2.47880015
69Optic disc pallor (HP:0000543)2.44907562
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42601122
71Abnormal protein N-linked glycosylation (HP:0012347)2.42601122
72Abnormal protein glycosylation (HP:0012346)2.42601122
73Abnormal glycosylation (HP:0012345)2.42601122
74Hypomagnesemia (HP:0002917)2.41369074
75Cupped ear (HP:0000378)2.38997574
76Renal Fanconi syndrome (HP:0001994)2.38171634
77CNS demyelination (HP:0007305)2.36084566
78Septo-optic dysplasia (HP:0100842)2.35774437
79Nasolacrimal duct obstruction (HP:0000579)2.33996149
80Type I transferrin isoform profile (HP:0003642)2.33544113
81Intention tremor (HP:0002080)2.33088646
82Abnormality of the renal medulla (HP:0100957)2.31476957
83Supranuclear gaze palsy (HP:0000605)2.31100959
84Duplicated collecting system (HP:0000081)2.26434612
85Congenital primary aphakia (HP:0007707)2.22091304
86Gait imbalance (HP:0002141)2.21956688
87Increased hepatocellular lipid droplets (HP:0006565)2.21410265
88Partial duplication of the phalanx of hand (HP:0009999)2.20547895
89Methylmalonic aciduria (HP:0012120)2.20282307
90Stomach cancer (HP:0012126)2.20188547
91Respiratory failure (HP:0002878)2.19670767
92Hypothermia (HP:0002045)2.19634134
93Nephrogenic diabetes insipidus (HP:0009806)2.15415667
94Esophageal atresia (HP:0002032)2.14766462
95Hypoplastic pelvis (HP:0008839)2.14556165
96Lethargy (HP:0001254)2.14365133
97Hypoplasia of the uterus (HP:0000013)2.13937643
98Degeneration of anterior horn cells (HP:0002398)2.12319733
99Abnormality of the anterior horn cell (HP:0006802)2.12319733
100Dysmetria (HP:0001310)2.11143335
101Asplenia (HP:0001746)2.11071587
102Vaginal atresia (HP:0000148)2.10122671
103Adrenal hypoplasia (HP:0000835)2.08754994
104Increased intramyocellular lipid droplets (HP:0012240)2.08434724
105Methylmalonic acidemia (HP:0002912)2.07120535
106Akinesia (HP:0002304)2.06966568
107Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06901993
108Inability to walk (HP:0002540)2.03521850
109Chronic hepatic failure (HP:0100626)2.03507641
110Termporal pattern (HP:0011008)2.03222976
111Insidious onset (HP:0003587)2.03222976
112Synostosis involving the elbow (HP:0003938)2.02357139
113Humeroradial synostosis (HP:0003041)2.02357139
114Abnormal hair whorl (HP:0010721)2.02137474
115Spastic paraparesis (HP:0002313)2.01360138
116Scanning speech (HP:0002168)2.01304584
117Ankle clonus (HP:0011448)2.00930826
118Attenuation of retinal blood vessels (HP:0007843)2.00507633
119Aplasia/Hypoplasia of the tibia (HP:0005772)1.98845720
120Abnormality of urine glucose concentration (HP:0011016)1.98501196
121Glycosuria (HP:0003076)1.98501196
122Genital tract atresia (HP:0001827)1.98184969
123Poor speech (HP:0002465)1.98009192
124Metabolic alkalosis (HP:0200114)1.96923863
125Abnormality of macular pigmentation (HP:0008002)1.96427151
126Pheochromocytoma (HP:0002666)1.96365991
127Abolished electroretinogram (ERG) (HP:0000550)1.95601957
128Ketoacidosis (HP:0001993)1.95152631
129Ketosis (HP:0001946)1.94003101
130Partial agenesis of the corpus callosum (HP:0001338)1.93785190
1313-Methylglutaconic aciduria (HP:0003535)1.93683858
132Increased muscle lipid content (HP:0009058)1.93255398
133Hyperglycinuria (HP:0003108)1.91800562
134Azoospermia (HP:0000027)1.91613062
135Neuroendocrine neoplasm (HP:0100634)1.91065983
136Progressive inability to walk (HP:0002505)1.89979802
137Aplasia/Hypoplasia of the spleen (HP:0010451)1.89852048
138Decreased central vision (HP:0007663)1.89493495
139Abnormal biliary tract physiology (HP:0012439)1.88675195
140Bile duct proliferation (HP:0001408)1.88675195
141Aplasia involving bones of the extremities (HP:0009825)1.87896885
142Aplasia involving bones of the upper limbs (HP:0009823)1.87896885
143Aplasia of the phalanges of the hand (HP:0009802)1.87896885
144Cerebral hemorrhage (HP:0001342)1.87774240
145Erythroderma (HP:0001019)1.84879240
146Short tibia (HP:0005736)1.84168410
147Abnormality of the nasolacrimal system (HP:0000614)1.83863554
148Hypokalemic alkalosis (HP:0001949)1.83579883
149Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83194679
150Hyperventilation (HP:0002883)1.82933032
151Abnormality of the salivary glands (HP:0010286)1.82262508
152Aplasia/hypoplasia of the uterus (HP:0008684)1.82018285
153Focal motor seizures (HP:0011153)1.81944649
154Myelomeningocele (HP:0002475)1.81854605
155Increased circulating renin level (HP:0000848)1.81301896
156Abnormality of magnesium homeostasis (HP:0004921)1.80733663
157Gastrointestinal atresia (HP:0002589)1.79248217
158Abnormality of the middle phalanges of the toes (HP:0010183)1.78935773
159Clumsiness (HP:0002312)1.78753889
160Brushfield spots (HP:0001088)1.77252865
161Hypoplasia of the iris (HP:0007676)1.76714669
162Generalized aminoaciduria (HP:0002909)1.76005600
163Febrile seizures (HP:0002373)1.75994429
164Anomalous pulmonary venous return (HP:0010772)1.75759446
165Mixed hearing impairment (HP:0000410)1.75664054
166Polydipsia (HP:0001959)1.75169564
167Abnormal drinking behavior (HP:0030082)1.75169564
168Abnormal rod and cone electroretinograms (HP:0008323)1.74997749
169Reduced antithrombin III activity (HP:0001976)1.74612592
170Polyuria (HP:0000103)1.74605001
171Abnormality of the fetal cardiovascular system (HP:0010948)1.74081244
172Abnormal umbilical cord blood vessels (HP:0011403)1.74081244
173Single umbilical artery (HP:0001195)1.74081244
174Abnormality of the lacrimal duct (HP:0011481)1.73261621
175Abnormality of B cell number (HP:0010975)1.72897041
176Cerebellar dysplasia (HP:0007033)1.72693361
177Slow saccadic eye movements (HP:0000514)1.72611802
178Duplication of thumb phalanx (HP:0009942)1.72509813
179Median cleft lip (HP:0000161)1.72038944
180Exertional dyspnea (HP:0002875)1.71995594
181Postnatal microcephaly (HP:0005484)1.70440238
182Hyperglycinemia (HP:0002154)1.70064902
183Abnormality of dicarboxylic acid metabolism (HP:0010995)1.69001348
184Dicarboxylic aciduria (HP:0003215)1.69001348
185Cystic liver disease (HP:0006706)1.68033141
186Progressive microcephaly (HP:0000253)1.66273035
187Dyskinesia (HP:0100660)1.63989745
188Dynein arm defect of respiratory motile cilia (HP:0012255)1.63480756
189Absent/shortened dynein arms (HP:0200106)1.63480756
190Abnormal spermatogenesis (HP:0008669)1.62813109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.30861800
2OXSR14.66363306
3ZAK3.35103633
4MAP4K23.23252657
5FRK3.21611629
6EPHB12.81103601
7TIE12.76937866
8BCR2.71650369
9CDK192.63764959
10PBK2.62115069
11CASK2.52270229
12BCKDK2.49445989
13PKN12.41879001
14NEK62.40532949
15PINK12.35141202
16NUAK12.34943610
17MAPKAPK52.33584475
18MET2.28596949
19WNK42.18155940
20LMTK22.17730027
21TAOK32.02496674
22FGFR22.01204517
23STK162.00350712
24BMPR1B1.93961130
25TNIK1.90651692
26CLK11.83942477
27MST41.79724777
28WNK31.76643028
29CSNK1G31.64521133
30MAP3K41.64346152
31WNK11.62247579
32TRIM281.59562838
33CSNK1A1L1.48339559
34MAP3K121.48046565
35CAMK2B1.47876176
36ROCK21.46839265
37LIMK11.45683062
38UHMK11.39176399
39TEC1.37912039
40MAP2K71.36413628
41PRPF4B1.33140052
42MAPK151.30200107
43FGR1.27318496
44EIF2AK31.26522591
45VRK21.23887827
46STK38L1.22967648
47ACVR1B1.22629942
48CSNK1G11.21586284
49CDK81.14243863
50DYRK21.13787801
51CAMK2D1.12887499
52PIM21.11002030
53IRAK21.08960022
54MAPKAPK31.05147506
55ERBB31.03204946
56MKNK10.99155718
57DAPK20.98052567
58CCNB10.95834937
59MUSK0.95011642
60CSNK1G20.94670475
61NTRK10.94540653
62PNCK0.94509928
63TRPM70.93629469
64SGK2230.92334311
65SGK4940.92334311
66CAMK2G0.88945565
67MAP2K60.88406000
68BLK0.85367819
69PRKCQ0.84585683
70YES10.81497137
71IRAK10.79917837
72BUB10.77306510
73NEK10.74821215
74PRKCG0.70929504
75IKBKB0.69110954
76RPS6KA50.69092466
77MAP3K50.68922350
78TGFBR10.68293027
79PIK3CA0.67770395
80DAPK10.67059242
81MKNK20.66331422
82MAPK70.65252196
83TLK10.65163415
84VRK10.64801013
85PRKCE0.64542238
86ADRBK20.64395941
87NTRK30.63710222
88EPHA40.62282154
89PIK3CG0.62280036
90AKT30.62139199
91TESK20.61554061
92PLK40.60948438
93PLK20.60665950
94FLT30.59255890
95ICK0.57608316
96PAK30.57207432
97ATR0.56039036
98CAMK2A0.55532313
99MAP3K130.53813473
100MAPK130.53044669
101MAP2K20.52879277
102PRKD10.52873834
103NME10.52633815
104PDK20.52276978
105MINK10.52016518
106KDR0.51160741
107CDK140.49116577
108SCYL20.48756674
109SRPK10.48708827
110HIPK20.48152979
111CSF1R0.46360682
112PLK30.45810922
113ADRBK10.45292608
114PLK10.44956631
115FYN0.43431821
116TXK0.43384700
117PRKG10.43107871
118PRKACA0.43006396
119ITK0.42029252
120MARK20.41444960
121CDK150.41159456
122PIM10.40341330
123CSNK1A10.40227213
124GRK10.39845044
125CDK11A0.39764899
126CDK180.39651260
127CDK30.38996136
128CSNK2A10.38735020
129CDK50.38488019
130MATK0.37837559
131GRK70.37611585
132ARAF0.37347056
133PRKCA0.37244909
134CAMKK20.37184437
135STK30.36469563
136MELK0.35128337
137RPS6KA40.34751685
138LCK0.34699787
139ATM0.34569115
140PDGFRB0.34469469
141ERBB40.34052677
142IRAK40.33932141
143CSNK1D0.33673419
144INSRR0.33455913
145GSK3A0.33438086
146PHKG10.33214425
147PHKG20.33214425
148PAK10.32280930
149OBSCN0.31888939
150BTK0.31301466
151CSNK2A20.31298406
152MARK10.31270111
153PDPK10.30806087
154GRK50.30795284
155CSK0.30665087
156TNK20.29060938
157KIT0.28469526
158PRKACB0.27497056
159TYRO30.27020359
160BMPR20.26218207

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000624.83080540
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.68198582
3Steroid biosynthesis_Homo sapiens_hsa001004.49215322
4Protein export_Homo sapiens_hsa030603.67965711
5Ether lipid metabolism_Homo sapiens_hsa005653.38270009
6* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.19070851
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76319634
8Sulfur metabolism_Homo sapiens_hsa009202.43679977
9Oxidative phosphorylation_Homo sapiens_hsa001902.27493922
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.15388992
11Sphingolipid metabolism_Homo sapiens_hsa006002.11229321
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.06868234
13Vitamin B6 metabolism_Homo sapiens_hsa007501.97776711
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.87404643
15Linoleic acid metabolism_Homo sapiens_hsa005911.83385948
16Selenocompound metabolism_Homo sapiens_hsa004501.72510406
17Nitrogen metabolism_Homo sapiens_hsa009101.69673096
18Parkinsons disease_Homo sapiens_hsa050121.63152831
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54934958
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.53049238
21Histidine metabolism_Homo sapiens_hsa003401.51672699
22Axon guidance_Homo sapiens_hsa043601.42936608
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.42023312
24Tryptophan metabolism_Homo sapiens_hsa003801.38265404
25Arachidonic acid metabolism_Homo sapiens_hsa005901.37603326
26Alzheimers disease_Homo sapiens_hsa050101.33214728
27Fanconi anemia pathway_Homo sapiens_hsa034601.31574130
28Vibrio cholerae infection_Homo sapiens_hsa051101.27388312
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27221513
30Autoimmune thyroid disease_Homo sapiens_hsa053201.22182642
31Glutathione metabolism_Homo sapiens_hsa004801.21610269
32Arginine and proline metabolism_Homo sapiens_hsa003301.21556927
33beta-Alanine metabolism_Homo sapiens_hsa004101.20485058
34RNA degradation_Homo sapiens_hsa030181.20482003
35Basal transcription factors_Homo sapiens_hsa030221.13903119
36Nicotine addiction_Homo sapiens_hsa050331.12561495
37Folate biosynthesis_Homo sapiens_hsa007901.10704705
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07842526
39Caffeine metabolism_Homo sapiens_hsa002321.06755226
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04354935
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.02822340
42Pyrimidine metabolism_Homo sapiens_hsa002401.01098730
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00666221
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99113324
45Serotonergic synapse_Homo sapiens_hsa047260.97824905
46Butanoate metabolism_Homo sapiens_hsa006500.97571981
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96798111
48Nucleotide excision repair_Homo sapiens_hsa034200.94983852
49Base excision repair_Homo sapiens_hsa034100.94203485
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.93983090
51Lysosome_Homo sapiens_hsa041420.93522019
52Mismatch repair_Homo sapiens_hsa034300.93171570
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91501917
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89731085
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87965697
56Collecting duct acid secretion_Homo sapiens_hsa049660.85388277
57Rheumatoid arthritis_Homo sapiens_hsa053230.85325592
58One carbon pool by folate_Homo sapiens_hsa006700.84962074
59Vitamin digestion and absorption_Homo sapiens_hsa049770.84428228
60RNA polymerase_Homo sapiens_hsa030200.84397132
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83763556
62Proteasome_Homo sapiens_hsa030500.83361737
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82781391
64Fat digestion and absorption_Homo sapiens_hsa049750.82014003
65Primary immunodeficiency_Homo sapiens_hsa053400.82011508
66Renal cell carcinoma_Homo sapiens_hsa052110.81778929
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79627871
68Tight junction_Homo sapiens_hsa045300.78505412
69Phenylalanine metabolism_Homo sapiens_hsa003600.78324300
70Non-homologous end-joining_Homo sapiens_hsa034500.77968685
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77886357
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77830105
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.76955929
74Huntingtons disease_Homo sapiens_hsa050160.74951796
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73694506
76Phototransduction_Homo sapiens_hsa047440.73449447
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72564173
78Olfactory transduction_Homo sapiens_hsa047400.71482009
79Regulation of autophagy_Homo sapiens_hsa041400.69871841
80Retinol metabolism_Homo sapiens_hsa008300.66582857
81Fatty acid degradation_Homo sapiens_hsa000710.65820484
82Taste transduction_Homo sapiens_hsa047420.65662133
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.64821811
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64753210
85Synaptic vesicle cycle_Homo sapiens_hsa047210.64332389
86Chemical carcinogenesis_Homo sapiens_hsa052040.64292561
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63727916
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63609377
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61158928
90Phagosome_Homo sapiens_hsa041450.60053598
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.59969043
92Type I diabetes mellitus_Homo sapiens_hsa049400.59746471
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58923307
94Peroxisome_Homo sapiens_hsa041460.57649405
95GABAergic synapse_Homo sapiens_hsa047270.56843197
96* Metabolic pathways_Homo sapiens_hsa011000.55714306
97Ras signaling pathway_Homo sapiens_hsa040140.53835148
98RNA transport_Homo sapiens_hsa030130.53784997
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53743691
100Sulfur relay system_Homo sapiens_hsa041220.52921646
101Propanoate metabolism_Homo sapiens_hsa006400.50597969
102Endocytosis_Homo sapiens_hsa041440.50177687
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.49585598
104Other glycan degradation_Homo sapiens_hsa005110.49064638
105Glutamatergic synapse_Homo sapiens_hsa047240.48068169
106Morphine addiction_Homo sapiens_hsa050320.46878513
107Pyruvate metabolism_Homo sapiens_hsa006200.44928198
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43172369
109Malaria_Homo sapiens_hsa051440.42396268
110Asthma_Homo sapiens_hsa053100.42260075
111Fatty acid metabolism_Homo sapiens_hsa012120.41412691
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40977824
113Ovarian steroidogenesis_Homo sapiens_hsa049130.39371159
114Hedgehog signaling pathway_Homo sapiens_hsa043400.38238286
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.38125501
116DNA replication_Homo sapiens_hsa030300.35850024
117Circadian rhythm_Homo sapiens_hsa047100.35588765
118Cocaine addiction_Homo sapiens_hsa050300.35504099
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.34774885
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34368893
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33418227
122Allograft rejection_Homo sapiens_hsa053300.32795135
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32748896
124Long-term depression_Homo sapiens_hsa047300.32671244
125Mineral absorption_Homo sapiens_hsa049780.32642452
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29936911
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.28932085
128Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28260695
129Pancreatic secretion_Homo sapiens_hsa049720.27640595
130Homologous recombination_Homo sapiens_hsa034400.27283650
131Hematopoietic cell lineage_Homo sapiens_hsa046400.25166714
132Graft-versus-host disease_Homo sapiens_hsa053320.25150181
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24636824
134Cardiac muscle contraction_Homo sapiens_hsa042600.23633538
135Purine metabolism_Homo sapiens_hsa002300.22149027
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22139838
137ABC transporters_Homo sapiens_hsa020100.21755512
138Alcoholism_Homo sapiens_hsa050340.19613438
139Ribosome_Homo sapiens_hsa030100.19572423
140Tyrosine metabolism_Homo sapiens_hsa003500.18716013

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