PIGHP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)5.67085353
2cytidine catabolic process (GO:0006216)5.67085353
3cytidine deamination (GO:0009972)5.67085353
4pyrimidine ribonucleoside catabolic process (GO:0046133)5.19759708
5DNA deamination (GO:0045006)4.96089956
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.63252834
7mature B cell differentiation involved in immune response (GO:0002313)4.46854567
8positive regulation of gamma-delta T cell activation (GO:0046645)4.22532956
9regulation of B cell receptor signaling pathway (GO:0050855)4.19720581
10positive regulation of alpha-beta T cell proliferation (GO:0046641)4.10911380
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.07603251
12negative regulation by host of viral transcription (GO:0043922)3.90251038
13positive regulation of B cell differentiation (GO:0045579)3.78440536
14Arp2/3 complex-mediated actin nucleation (GO:0034314)3.69071747
15neural tube formation (GO:0001841)3.66155949
16positive T cell selection (GO:0043368)3.57277766
17negative regulation of T cell apoptotic process (GO:0070233)3.56803759
18mature B cell differentiation (GO:0002335)3.56166129
19positive regulation of granulocyte differentiation (GO:0030854)3.54572299
20metallo-sulfur cluster assembly (GO:0031163)3.52792406
21iron-sulfur cluster assembly (GO:0016226)3.52792406
22regulation of B cell differentiation (GO:0045577)3.45031986
23cell wall macromolecule metabolic process (GO:0044036)3.44060706
24positive thymic T cell selection (GO:0045059)3.43402720
25regulation of gamma-delta T cell differentiation (GO:0045586)3.41770028
26neutrophil activation (GO:0042119)3.39388247
27regulation of activation of Janus kinase activity (GO:0010533)3.36050741
28negative T cell selection (GO:0043383)3.35377941
29positive regulation of calcium-mediated signaling (GO:0050850)3.27295816
30regulation of alpha-beta T cell proliferation (GO:0046640)3.26824641
31granulocyte activation (GO:0036230)3.25153823
32actin nucleation (GO:0045010)3.24379756
33dopamine transport (GO:0015872)3.22827398
34T cell migration (GO:0072678)3.16646909
35negative thymic T cell selection (GO:0045060)3.14692909
36regulation of memory T cell differentiation (GO:0043380)3.11499047
37DNA demethylation (GO:0080111)3.10271529
38regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06531916
39mast cell activation (GO:0045576)3.04887200
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.01306564
41regulation of gamma-delta T cell activation (GO:0046643)2.93557599
42positive regulation of interleukin-8 secretion (GO:2000484)2.93349239
43positive regulation of T cell differentiation in thymus (GO:0033089)2.92192520
44positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.88483513
45adenosine metabolic process (GO:0046085)2.87362055
46regulation of Golgi to plasma membrane protein transport (GO:0042996)2.86372077
47S-adenosylmethionine metabolic process (GO:0046500)2.84128224
48piRNA metabolic process (GO:0034587)2.84127506
49positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.83686763
50negative regulation of thymocyte apoptotic process (GO:0070244)2.80535478
51negative regulation of lymphocyte apoptotic process (GO:0070229)2.79968821
52regulation of T-helper 1 cell differentiation (GO:0045625)2.79451929
53mast cell activation involved in immune response (GO:0002279)2.79099367
54mast cell degranulation (GO:0043303)2.79099367
55positive regulation of defense response to virus by host (GO:0002230)2.77447934
56positive regulation of T cell cytokine production (GO:0002726)2.75559007
57Peyers patch development (GO:0048541)2.74177173
58mucosal-associated lymphoid tissue development (GO:0048537)2.74177173
59protein complex biogenesis (GO:0070271)2.71762299
60negative regulation of B cell apoptotic process (GO:0002903)2.68133595
61modulation by host of symbiont transcription (GO:0052472)2.67650342
62modulation by host of viral transcription (GO:0043921)2.67650342
63pyrimidine nucleoside catabolic process (GO:0046135)2.66972626
64nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.66639444
65catecholamine transport (GO:0051937)2.66626881
66positive regulation of interleukin-2 production (GO:0032743)2.66391324
67purine nucleotide salvage (GO:0032261)2.66078136
68regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.64311349
69positive regulation of tolerance induction (GO:0002645)2.63714590
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63100156
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.63100156
72positive regulation of natural killer cell differentiation (GO:0032825)2.62337739
73positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.61219540
74positive regulation of monocyte chemotaxis (GO:0090026)2.59908527
75T cell receptor signaling pathway (GO:0050852)2.58084427
76myeloid leukocyte mediated immunity (GO:0002444)2.57824951
77T cell selection (GO:0045058)2.57201474
78regulation of regulatory T cell differentiation (GO:0045589)2.56691305
79regulation of calcium-mediated signaling (GO:0050848)2.56602826
80monoamine transport (GO:0015844)2.56060251
81neurotransmitter catabolic process (GO:0042135)2.55305453
82modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.55288196
83response to peptidoglycan (GO:0032494)2.55077463
84dendritic cell chemotaxis (GO:0002407)2.55032063
85regulation of germinal center formation (GO:0002634)2.52496349
86DNA dealkylation (GO:0035510)2.51396839
87regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.51228568
88antigen receptor-mediated signaling pathway (GO:0050851)2.50601260
89negative regulation of viral genome replication (GO:0045071)2.50523554
90neutrophil activation involved in immune response (GO:0002283)2.50007762
91synapsis (GO:0007129)2.48614029
92auditory receptor cell stereocilium organization (GO:0060088)2.48569591
93leukocyte degranulation (GO:0043299)2.48546565
94mitotic G2 DNA damage checkpoint (GO:0007095)2.48377805
95regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.47230434
96neutrophil mediated immunity (GO:0002446)2.45728967
97cell wall macromolecule catabolic process (GO:0016998)2.44081929
98positive regulation of lymphocyte differentiation (GO:0045621)2.42887341
99positive regulation of interleukin-1 beta secretion (GO:0050718)2.42846737
100positive regulation of T-helper 1 type immune response (GO:0002827)2.42793437

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.30111782
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.75447381
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.65333409
4IGF1R_20145208_ChIP-Seq_DFB_Human3.48661415
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.08970308
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.06567545
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.93357175
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78606394
9VDR_23849224_ChIP-Seq_CD4+_Human2.51468132
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.51323380
11MYB_26560356_Chip-Seq_TH2_Human2.51110669
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.38190151
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27997078
14GATA1_22025678_ChIP-Seq_K562_Human2.20008086
15ZNF274_21170338_ChIP-Seq_K562_Hela2.19791644
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.09503344
17ELK1_19687146_ChIP-ChIP_HELA_Human2.01330430
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.95048735
19GABP_17652178_ChIP-ChIP_JURKAT_Human1.93804446
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91590219
21RUNX_20019798_ChIP-Seq_JUKART_Human1.90608855
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89517752
23FOXP3_21729870_ChIP-Seq_TREG_Human1.86970400
24GATA3_26560356_Chip-Seq_TH2_Human1.84134848
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81094782
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76645853
27EWS_26573619_Chip-Seq_HEK293_Human1.75258758
28GATA3_27048872_Chip-Seq_THYMUS_Human1.72328098
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.72207218
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66998268
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66822426
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.64162186
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63749225
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59711175
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58479631
36MYB_26560356_Chip-Seq_TH1_Human1.57025730
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55509744
38SPI1_23547873_ChIP-Seq_NB4_Human1.55274410
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54019529
40GBX2_23144817_ChIP-Seq_PC3_Human1.53903808
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51604462
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47949023
43FUS_26573619_Chip-Seq_HEK293_Human1.44931140
44ER_23166858_ChIP-Seq_MCF-7_Human1.42034231
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39591708
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35007352
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34073988
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33929422
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33661635
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32832663
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.31345843
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.29961560
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25644390
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23655799
55TAF15_26573619_Chip-Seq_HEK293_Human1.22848315
56TP53_22573176_ChIP-Seq_HFKS_Human1.22561149
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22488049
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21115447
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19969345
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.18721510
61PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.14126126
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11489679
63CIITA_25753668_ChIP-Seq_RAJI_Human1.11396602
64GATA3_26560356_Chip-Seq_TH1_Human1.09237710
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08834049
66CBP_20019798_ChIP-Seq_JUKART_Human1.08834049
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07389704
68AR_20517297_ChIP-Seq_VCAP_Human1.07291071
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06841396
70P300_19829295_ChIP-Seq_ESCs_Human1.05717673
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.05576378
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05576378
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02366829
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02232955
75IRF1_19129219_ChIP-ChIP_H3396_Human1.02139158
76NANOG_19829295_ChIP-Seq_ESCs_Human1.01722395
77SOX2_19829295_ChIP-Seq_ESCs_Human1.01722395
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01527428
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99662878
80SALL4_22934838_ChIP-ChIP_CD34+_Human0.98521054
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96531328
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95658449
83ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95197728
84SCL_19346495_ChIP-Seq_HPC-7_Human0.94806644
85VDR_24787735_ChIP-Seq_THP-1_Human0.93745766
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93263273
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93172002
88TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92876175
89CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92841945
90SALL1_21062744_ChIP-ChIP_HESCs_Human0.92586672
91HOXB7_26014856_ChIP-Seq_BT474_Human0.92033953
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91667690
93VDR_22108803_ChIP-Seq_LS180_Human0.89651580
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88890893
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86753396
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.85765137
97PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83884329
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.83569743
99E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82608610
100EGR1_19374776_ChIP-ChIP_THP-1_Human0.82561749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.70362413
2MP0005671_abnormal_response_to3.34587973
3MP0008877_abnormal_DNA_methylation3.21225307
4MP0002009_preneoplasia2.79153047
5MP0003787_abnormal_imprinting2.77957696
6MP0001986_abnormal_taste_sensitivity2.71449465
7MP0005000_abnormal_immune_tolerance2.61980841
8MP0001800_abnormal_humoral_immune2.56689572
9MP0003436_decreased_susceptibility_to2.56670449
10MP0005646_abnormal_pituitary_gland2.45350921
11MP0002166_altered_tumor_susceptibility2.38409838
12MP0003252_abnormal_bile_duct2.30009313
13MP0003724_increased_susceptibility_to2.26658315
14MP0002148_abnormal_hypersensitivity_rea2.25629479
15MP0003763_abnormal_thymus_physiology2.19944172
16MP0009785_altered_susceptibility_to2.19593429
17MP0002723_abnormal_immune_serum2.14689817
18MP0002420_abnormal_adaptive_immunity2.10591776
19MP0000465_gastrointestinal_hemorrhage2.10174985
20MP0001819_abnormal_immune_cell2.05441170
21MP0002398_abnormal_bone_marrow1.98892956
22MP0002452_abnormal_antigen_presenting1.97678892
23MP0002006_tumorigenesis1.93645281
24MP0009764_decreased_sensitivity_to1.89912054
25MP0000716_abnormal_immune_system1.77912134
26MP0005025_abnormal_response_to1.74976192
27MP0002419_abnormal_innate_immunity1.73104094
28MP0000689_abnormal_spleen_morphology1.68219100
29MP0005464_abnormal_platelet_physiology1.63145542
30MP0006082_CNS_inflammation1.62172957
31MP0002722_abnormal_immune_system1.61608506
32MP0002405_respiratory_system_inflammati1.58462258
33MP0002396_abnormal_hematopoietic_system1.53264397
34MP0008007_abnormal_cellular_replicative1.48547139
35MP0010155_abnormal_intestine_physiology1.46354477
36MP0000569_abnormal_digit_pigmentation1.44972860
37MP0000703_abnormal_thymus_morphology1.40718825
38MP0002429_abnormal_blood_cell1.40548049
39MP0006072_abnormal_retinal_apoptosis1.36295088
40MP0003172_abnormal_lysosome_physiology1.31280031
41MP0009697_abnormal_copulation1.31090861
42MP0002138_abnormal_hepatobiliary_system1.29642256
43MP0003786_premature_aging1.28335949
44MP0008058_abnormal_DNA_repair1.28141092
45MP0001845_abnormal_inflammatory_respons1.27537540
46MP0001919_abnormal_reproductive_system1.27458487
47MP0005389_reproductive_system_phenotype1.26798413
48MP0005410_abnormal_fertilization1.26577548
49MP0009333_abnormal_splenocyte_physiolog1.24138583
50MP0001533_abnormal_skeleton_physiology1.22407870
51MP0003866_abnormal_defecation1.20944043
52MP0001529_abnormal_vocalization1.20626272
53MP0003183_abnormal_peptide_metabolism1.20314327
54MP0006054_spinal_hemorrhage1.19227350
55MP0008469_abnormal_protein_level1.17708728
56MP0003186_abnormal_redox_activity1.16756972
57MP0005084_abnormal_gallbladder_morpholo1.15895477
58MP0008872_abnormal_physiological_respon1.15588034
59MP0001790_abnormal_immune_system1.15030097
60MP0005387_immune_system_phenotype1.15030097
61MP0001764_abnormal_homeostasis1.11417037
62MP0006036_abnormal_mitochondrial_physio1.05771064
63MP0002019_abnormal_tumor_incidence1.04167022
64MP0009278_abnormal_bone_marrow1.02369714
65MP0002876_abnormal_thyroid_physiology1.02258421
66MP0004808_abnormal_hematopoietic_stem1.00677545
67MP0008004_abnormal_stomach_pH1.00224413
68MP0003806_abnormal_nucleotide_metabolis0.99430793
69MP0003448_altered_tumor_morphology0.97609090
70MP0009763_increased_sensitivity_to0.96275414
71MP0001968_abnormal_touch/_nociception0.95052875
72MP0000372_irregular_coat_pigmentation0.91532695
73MP0005075_abnormal_melanosome_morpholog0.89745029
74MP0001501_abnormal_sleep_pattern0.89563255
75MP0002102_abnormal_ear_morphology0.88648075
76MP0004947_skin_inflammation0.88379996
77MP0003646_muscle_fatigue0.86361629
78MP0005397_hematopoietic_system_phenotyp0.86238523
79MP0001545_abnormal_hematopoietic_system0.86238523
80MP0003300_gastrointestinal_ulcer0.84863039
81MP0001542_abnormal_bone_strength0.82918437
82MP0008995_early_reproductive_senescence0.80192927
83MP0005319_abnormal_enzyme/_coenzyme0.76830101
84MP0002277_abnormal_respiratory_mucosa0.76560149
85MP0009765_abnormal_xenobiotic_induced0.75761814
86MP0005266_abnormal_metabolism0.75206052
87MP0003656_abnormal_erythrocyte_physiolo0.73484272
88MP0003638_abnormal_response/metabolism_0.73176613
89MP0006035_abnormal_mitochondrial_morpho0.72819905
90MP0003718_maternal_effect0.70778745
91MP0005174_abnormal_tail_pigmentation0.69995221
92MP0004134_abnormal_chest_morphology0.69981807
93MP0002933_joint_inflammation0.69084119
94MP0002736_abnormal_nociception_after0.68943613
95MP0000685_abnormal_immune_system0.67527122
96MP0001984_abnormal_olfaction0.66511546
97MP0005360_urolithiasis0.66302477
98MP0001119_abnormal_female_reproductive0.65995517
99MP0001853_heart_inflammation0.65715743
100MP0004145_abnormal_muscle_electrophysio0.65568565

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)4.70581953
2Type 2 muscle fiber atrophy (HP:0003554)4.61182975
3B lymphocytopenia (HP:0010976)4.51619306
4Abnormality of B cell number (HP:0010975)4.41069564
5Autoimmune hemolytic anemia (HP:0001890)4.10814528
6Muscle fiber atrophy (HP:0100295)3.91938526
7Granulocytopenia (HP:0001913)3.72676064
8Combined immunodeficiency (HP:0005387)3.71195484
9Elevated erythrocyte sedimentation rate (HP:0003565)3.65444110
10Thyroiditis (HP:0100646)3.54385843
11Stomatitis (HP:0010280)3.54215056
12Aplastic anemia (HP:0001915)3.53915797
13Eosinophilia (HP:0001880)3.53218217
14Panhypogammaglobulinemia (HP:0003139)3.47142850
15T lymphocytopenia (HP:0005403)3.44909763
16IgG deficiency (HP:0004315)3.43970827
17Abnormality of the prostate (HP:0008775)3.24737244
18Abnormality of T cell number (HP:0011839)3.24593388
19Abnormality of eosinophils (HP:0001879)3.13080313
20Recurrent fungal infections (HP:0002841)3.12528027
21Abnormality of T cells (HP:0002843)3.07484689
22Hypoproteinemia (HP:0003075)3.04155726
23Leukocytosis (HP:0001974)3.03535828
24Increased IgM level (HP:0003496)2.97803048
25Autoimmune thrombocytopenia (HP:0001973)2.96636262
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92269215
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92269215
28Encephalitis (HP:0002383)2.90508604
29Decreased electroretinogram (ERG) amplitude (HP:0000654)2.81935683
30Hypochromic microcytic anemia (HP:0004840)2.72160070
31Gastrointestinal infarctions (HP:0005244)2.71570664
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.69958746
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.69958746
34Abnormality of T cell physiology (HP:0011840)2.65277278
35Recurrent viral infections (HP:0004429)2.61228961
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.60121522
37Absent speech (HP:0001344)2.58557129
38Pustule (HP:0200039)2.52010650
39Metaphyseal dysplasia (HP:0100255)2.46593328
40Recurrent cutaneous fungal infections (HP:0011370)2.44547719
41Chronic mucocutaneous candidiasis (HP:0002728)2.44547719
42Fatigue (HP:0012378)2.43359158
43Hepatocellular necrosis (HP:0001404)2.42899594
44Agammaglobulinemia (HP:0004432)2.35342334
45Chronic diarrhea (HP:0002028)2.34978932
46Mesangial abnormality (HP:0001966)2.32841126
47Alveolar cell carcinoma (HP:0006519)2.31676072
48Pancreatic cysts (HP:0001737)2.30045103
49Recurrent bronchitis (HP:0002837)2.26963595
50Hyperventilation (HP:0002883)2.26765670
51Chest pain (HP:0100749)2.26708124
52Neoplasm of the tracheobronchial system (HP:0100552)2.25724228
53Amaurosis fugax (HP:0100576)2.25156021
54Increased intramyocellular lipid droplets (HP:0012240)2.23583204
55Neonatal respiratory distress (HP:0002643)2.22733959
56Carpal bone hypoplasia (HP:0001498)2.14556321
57Hypergammaglobulinemia (HP:0010702)2.12444505
58Meningitis (HP:0001287)2.06113845
59Abnormality of DNA repair (HP:0003254)2.06053902
60Hepatic necrosis (HP:0002605)2.05481219
61Spontaneous abortion (HP:0005268)2.05423868
62IgM deficiency (HP:0002850)1.98914477
63Decreased central vision (HP:0007663)1.98563414
64Abnormality of male internal genitalia (HP:0000022)1.97235447
65Prostate neoplasm (HP:0100787)1.96306283
66Spastic paraparesis (HP:0002313)1.96093353
67Abnormality of the heme biosynthetic pathway (HP:0010472)1.94791642
68Congenital stationary night blindness (HP:0007642)1.92555531
69Weak cry (HP:0001612)1.91182876
70Neutropenia (HP:0001875)1.90805929
71Widely spaced teeth (HP:0000687)1.87793365
72Facial diplegia (HP:0001349)1.86711137
73Myelodysplasia (HP:0002863)1.86561530
74Gingival bleeding (HP:0000225)1.85061574
75Recurrent skin infections (HP:0001581)1.84560168
76Increased muscle lipid content (HP:0009058)1.82384329
77Submucous cleft hard palate (HP:0000176)1.80653912
78Abnormality of the corticospinal tract (HP:0002492)1.80151725
79Abnormality of the renal cortex (HP:0011035)1.79965429
80Stomach cancer (HP:0012126)1.79832919
81Inflammation of the large intestine (HP:0002037)1.77124514
82Mitochondrial inheritance (HP:0001427)1.75541387
83Nephronophthisis (HP:0000090)1.73245389
84Aplasia/Hypoplasia of the tibia (HP:0005772)1.71272209
85Long clavicles (HP:0000890)1.69784490
86Increased IgE level (HP:0003212)1.66918457
87Epistaxis (HP:0000421)1.66363434
88Vasculitis (HP:0002633)1.66323636
89Abnormality of midbrain morphology (HP:0002418)1.65929093
90Molar tooth sign on MRI (HP:0002419)1.65929093
91Gangrene (HP:0100758)1.65737888
92True hermaphroditism (HP:0010459)1.64840518
93Pancytopenia (HP:0001876)1.64284855
94Cerebral edema (HP:0002181)1.64275356
95Recurrent abscess formation (HP:0002722)1.64132844
96Acute hepatic failure (HP:0006554)1.63206470
97Abnormal spermatogenesis (HP:0008669)1.61898822
98Abnormality of the neuromuscular junction (HP:0003398)1.61241686
99Fatigable weakness (HP:0003473)1.61241686
100Obstructive lung disease (HP:0006536)1.57920000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.67668652
2MAP4K22.98020492
3EIF2AK32.85428915
4BCKDK2.74832094
5TXK2.74558170
6BMPR22.72805741
7MAP4K12.46181587
8FES2.34119426
9KIT2.22933561
10PIK3CG2.21944760
11IKBKE2.10719127
12PIK3CA2.06699937
13KDR2.04672932
14FRK2.01791087
15MAP3K141.95501330
16CSF1R1.78312525
17ZAK1.78096198
18GRK61.72945466
19BRSK21.72328699
20CAMKK21.72092228
21TESK21.67199743
22IKBKB1.59359259
23ITK1.56751364
24MAP3K61.49086884
25TEC1.48760894
26SCYL21.47552454
27NUAK11.43877860
28BTK1.39634798
29SRPK11.39387709
30PINK11.36489978
31RIPK41.35568607
32FGR1.29876704
33FLT31.27280647
34SYK1.25309124
35ADRBK21.23924391
36MARK31.22783650
37ZAP701.17021244
38TBK11.14617628
39STK161.13303363
40BRD41.13202652
41LCK1.11650801
42AKT31.04288678
43MKNK11.02386081
44LYN1.01569952
45BLK0.97083614
46IRAK40.96709808
47GRK70.95891690
48JAK30.91910480
49PIM10.91266510
50WNK30.88287089
51ERBB30.85666641
52RPS6KA50.84165988
53CHUK0.77332602
54IRAK10.75776925
55GRK10.74336082
56MAPK130.72756284
57CCNB10.69571076
58DAPK20.68793978
59MAP3K50.67777822
60ABL10.67432076
61EIF2AK20.66826431
62MAP2K20.65706580
63PBK0.65047409
64TLK10.64472797
65MAPK110.61902274
66CDK30.59966898
67PRKCQ0.59645738
68MAP3K110.58791215
69HCK0.57535232
70ERBB20.55134922
71MAP2K70.54144152
72PAK30.53117665
73MATK0.52943377
74CSNK1G30.51832432
75MAP2K30.47900531
76TRIM280.47005260
77TAF10.46618626
78TNK20.46341591
79CSNK1G20.45460725
80NEK60.45294229
81CAMKK10.43803856
82IGF1R0.40305153
83CSNK1A1L0.39816426
84TIE10.39066047
85VRK10.38015676
86CSK0.36851950
87CSNK1D0.36620035
88CSNK1G10.36172755
89INSRR0.36026938
90TYK20.34931599
91EGFR0.34653695
92BMPR1B0.34396974
93MAP3K40.33586695
94CLK10.32678802
95AURKB0.32048768
96MAPK30.31868378
97RPS6KA40.31858355
98CDK60.31535059
99CSNK2A10.31091536
100VRK20.30712450

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.30591815
2Graft-versus-host disease_Homo sapiens_hsa053323.46368103
3Allograft rejection_Homo sapiens_hsa053303.23358416
4Autoimmune thyroid disease_Homo sapiens_hsa053202.98999907
5Asthma_Homo sapiens_hsa053102.77730126
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.74952994
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.67863983
8Proteasome_Homo sapiens_hsa030502.66682407
9Type I diabetes mellitus_Homo sapiens_hsa049402.36377427
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.35240092
11Protein export_Homo sapiens_hsa030602.26164871
12Antigen processing and presentation_Homo sapiens_hsa046122.22694813
13Hematopoietic cell lineage_Homo sapiens_hsa046402.02491167
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90304159
15RNA polymerase_Homo sapiens_hsa030201.86267728
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83440273
17T cell receptor signaling pathway_Homo sapiens_hsa046601.82191107
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68546602
19Leishmaniasis_Homo sapiens_hsa051401.61575460
20Rheumatoid arthritis_Homo sapiens_hsa053231.59441345
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.51877404
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50697282
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47075874
24Phototransduction_Homo sapiens_hsa047441.41742507
25Oxidative phosphorylation_Homo sapiens_hsa001901.34906414
26Propanoate metabolism_Homo sapiens_hsa006401.30029573
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26586989
28Herpes simplex infection_Homo sapiens_hsa051681.23924110
29Measles_Homo sapiens_hsa051621.23567392
30Staphylococcus aureus infection_Homo sapiens_hsa051501.21690640
31Shigellosis_Homo sapiens_hsa051311.18714075
32Homologous recombination_Homo sapiens_hsa034401.18060526
33Parkinsons disease_Homo sapiens_hsa050121.17585672
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.17336052
35Spliceosome_Homo sapiens_hsa030401.17214187
36RNA transport_Homo sapiens_hsa030131.16708302
37Nitrogen metabolism_Homo sapiens_hsa009101.15773096
38Systemic lupus erythematosus_Homo sapiens_hsa053221.14347229
39Legionellosis_Homo sapiens_hsa051341.08124128
40Non-homologous end-joining_Homo sapiens_hsa034500.99195872
41Viral myocarditis_Homo sapiens_hsa054160.95149159
42RNA degradation_Homo sapiens_hsa030180.95140721
43Peroxisome_Homo sapiens_hsa041460.92913044
44Basal transcription factors_Homo sapiens_hsa030220.91264200
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90894323
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88948077
47Pyrimidine metabolism_Homo sapiens_hsa002400.88868050
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88198931
49Purine metabolism_Homo sapiens_hsa002300.83577413
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80617296
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79848245
52Osteoclast differentiation_Homo sapiens_hsa043800.78186533
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77254873
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.76263791
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74787492
56Mismatch repair_Homo sapiens_hsa034300.74624878
57Regulation of autophagy_Homo sapiens_hsa041400.74132385
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72426844
59Fanconi anemia pathway_Homo sapiens_hsa034600.71624369
60Salmonella infection_Homo sapiens_hsa051320.70863032
61B cell receptor signaling pathway_Homo sapiens_hsa046620.69780461
62Tuberculosis_Homo sapiens_hsa051520.69536253
63Linoleic acid metabolism_Homo sapiens_hsa005910.69362568
64Arachidonic acid metabolism_Homo sapiens_hsa005900.68925981
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67491131
66Butanoate metabolism_Homo sapiens_hsa006500.67250003
67Epstein-Barr virus infection_Homo sapiens_hsa051690.66978509
68Acute myeloid leukemia_Homo sapiens_hsa052210.66354364
69Base excision repair_Homo sapiens_hsa034100.65810509
70Influenza A_Homo sapiens_hsa051640.62161049
71Toxoplasmosis_Homo sapiens_hsa051450.60961892
72Chemical carcinogenesis_Homo sapiens_hsa052040.60470201
73Olfactory transduction_Homo sapiens_hsa047400.59647461
74mRNA surveillance pathway_Homo sapiens_hsa030150.58869737
75Nucleotide excision repair_Homo sapiens_hsa034200.57755102
76TNF signaling pathway_Homo sapiens_hsa046680.54694099
77DNA replication_Homo sapiens_hsa030300.50561094
78Pertussis_Homo sapiens_hsa051330.49773347
79Fatty acid elongation_Homo sapiens_hsa000620.45837282
80Huntingtons disease_Homo sapiens_hsa050160.45353748
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44400122
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.43311870
83Caffeine metabolism_Homo sapiens_hsa002320.42808109
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40495416
85Chemokine signaling pathway_Homo sapiens_hsa040620.39833716
86Malaria_Homo sapiens_hsa051440.37068771
87Alzheimers disease_Homo sapiens_hsa050100.36328118
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34936698
89p53 signaling pathway_Homo sapiens_hsa041150.33445058
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32832122
91Ribosome_Homo sapiens_hsa030100.32298291
92African trypanosomiasis_Homo sapiens_hsa051430.32015444
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31457667
94ABC transporters_Homo sapiens_hsa020100.29353284
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.27560385
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27418082
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.27327570
98Platelet activation_Homo sapiens_hsa046110.26505948
99Hepatitis B_Homo sapiens_hsa051610.26441705
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24938570

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