PIGK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand renaturation (GO:0000733)5.51098451
2proteasome assembly (GO:0043248)4.96063691
3regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.91315254
4positive regulation of oligodendrocyte differentiation (GO:0048714)4.31219176
5regulation of respiratory system process (GO:0044065)4.02968595
6synaptic vesicle exocytosis (GO:0016079)4.00620671
7neuronal action potential propagation (GO:0019227)3.94304842
8signal peptide processing (GO:0006465)3.88865193
9positive regulation of protein autophosphorylation (GO:0031954)3.88050235
10DNA double-strand break processing (GO:0000729)3.74706644
11rRNA methylation (GO:0031167)3.70147112
12forebrain morphogenesis (GO:0048853)3.51765038
13synaptic vesicle maturation (GO:0016188)3.50427322
14mitotic sister chromatid cohesion (GO:0007064)3.49949595
15regulation of short-term neuronal synaptic plasticity (GO:0048172)3.46674572
16lactate metabolic process (GO:0006089)3.42184752
17inositol phosphate catabolic process (GO:0071545)3.38353994
18gamma-aminobutyric acid transport (GO:0015812)3.38210605
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.37193771
20cullin deneddylation (GO:0010388)3.36918756
21regulation of synaptic vesicle exocytosis (GO:2000300)3.36738869
22regulation of hexokinase activity (GO:1903299)3.36052577
23regulation of glucokinase activity (GO:0033131)3.36052577
24locomotory exploration behavior (GO:0035641)3.30929485
25rRNA modification (GO:0000154)3.30213797
26mitotic nuclear envelope reassembly (GO:0007084)3.25409834
27nuclear envelope reassembly (GO:0031468)3.25409834
28regulation of respiratory gaseous exchange (GO:0043576)3.21764475
29mitochondrial calcium ion homeostasis (GO:0051560)3.20083431
30antigen processing and presentation via MHC class Ib (GO:0002475)3.19370361
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19197260
32neurotransmitter secretion (GO:0007269)3.18953721
33beta-amyloid metabolic process (GO:0050435)3.17908945
34replication fork processing (GO:0031297)3.15599093
35purine nucleobase biosynthetic process (GO:0009113)3.15292364
36vocalization behavior (GO:0071625)3.13606102
37non-recombinational repair (GO:0000726)3.12144413
38double-strand break repair via nonhomologous end joining (GO:0006303)3.12144413
39glutamate secretion (GO:0014047)3.11885107
40prenylation (GO:0097354)3.06968814
41protein prenylation (GO:0018342)3.06968814
42inositol phosphate dephosphorylation (GO:0046855)3.06027209
43phosphorylated carbohydrate dephosphorylation (GO:0046838)3.06027209
44ketone body metabolic process (GO:1902224)3.06008660
45regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.05483406
46regulation of mitochondrial translation (GO:0070129)3.04417857
47cellular ketone body metabolic process (GO:0046950)3.02660431
48phospholipid dephosphorylation (GO:0046839)3.02651125
49ribosome assembly (GO:0042255)3.02437617
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02088629
51DNA ligation (GO:0006266)3.01233544
52neurotransmitter-gated ion channel clustering (GO:0072578)3.01195898
53establishment of integrated proviral latency (GO:0075713)2.99655584
54respiratory chain complex IV assembly (GO:0008535)2.97754411
55protein deneddylation (GO:0000338)2.96871564
56bone trabecula formation (GO:0060346)2.95856092
57synaptic vesicle docking involved in exocytosis (GO:0016081)2.95644617
58regulation of synaptic vesicle transport (GO:1902803)2.94087753
59regulation of mitotic spindle organization (GO:0060236)2.92654551
60positive regulation of actin filament depolymerization (GO:0030836)2.91379016
61positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.91175135
62presynaptic membrane assembly (GO:0097105)2.89921942
63Golgi transport vesicle coating (GO:0048200)2.88317292
64COPI coating of Golgi vesicle (GO:0048205)2.88317292
65activation of protein kinase A activity (GO:0034199)2.86601308
66regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.85742085
67phosphatidylinositol dephosphorylation (GO:0046856)2.84983349
68regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.83662492
69COPII vesicle coating (GO:0048208)2.81867321
70regulation of integrin-mediated signaling pathway (GO:2001044)2.81207027
71platelet dense granule organization (GO:0060155)2.80058873
72retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.79922812
73regulation of acyl-CoA biosynthetic process (GO:0050812)2.77898112
74negative regulation of DNA-dependent DNA replication (GO:2000104)2.77819257
75regulation of DNA endoreduplication (GO:0032875)2.77407879
76neuron cell-cell adhesion (GO:0007158)2.76929084
77pinocytosis (GO:0006907)2.75919928
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.75744586
79nuclear pore organization (GO:0006999)2.75514730
80positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.74153189
81spindle checkpoint (GO:0031577)2.73438625
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72856766
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72856766
84positive regulation of mitotic sister chromatid separation (GO:1901970)2.72856766
85response to pheromone (GO:0019236)2.72558370
86establishment of protein localization to mitochondrial membrane (GO:0090151)2.72245548
87neuromuscular process controlling posture (GO:0050884)2.71811133
88negative regulation of complement activation (GO:0045916)2.71364935
89nucleobase biosynthetic process (GO:0046112)2.70165948
90regulation of amyloid precursor protein catabolic process (GO:1902991)2.67622563
91synapsis (GO:0007129)2.67610051
92protein localization to kinetochore (GO:0034501)2.66245953
93UDP-N-acetylglucosamine metabolic process (GO:0006047)2.64120597
94regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.64079347
95regulation of Rac protein signal transduction (GO:0035020)2.64017403
96mitotic metaphase plate congression (GO:0007080)2.62803516
97positive regulation of synaptic transmission, GABAergic (GO:0032230)2.61428938
98metaphase plate congression (GO:0051310)2.61314250
99pteridine-containing compound biosynthetic process (GO:0042559)2.61011310
100proline transport (GO:0015824)2.60020226
101branched-chain amino acid catabolic process (GO:0009083)2.59406539
102regulation of glutamate receptor signaling pathway (GO:1900449)2.59183099
103regulation of beta-amyloid formation (GO:1902003)2.58222330
104tRNA aminoacylation for protein translation (GO:0006418)2.57699756
105neurotransmitter transport (GO:0006836)2.57308640
106lipid particle organization (GO:0034389)2.57110063
107mitochondrial DNA replication (GO:0006264)2.56137521
108postsynaptic membrane organization (GO:0001941)2.55814589
109positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.55635439
110zinc ion transport (GO:0006829)2.55375532
111tRNA aminoacylation (GO:0043039)2.55355576
112amino acid activation (GO:0043038)2.55355576
113cytochrome complex assembly (GO:0017004)2.55028169
114intraciliary transport (GO:0042073)2.54822466
115protein localization to synapse (GO:0035418)2.54008368
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.53973196
117regulation of mitotic metaphase/anaphase transition (GO:0030071)2.53973196
118polyol catabolic process (GO:0046174)2.53102046
119response to X-ray (GO:0010165)2.51885935
120vesicle transport along microtubule (GO:0047496)2.51720924
121regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.51631719
122cerebellar Purkinje cell layer development (GO:0021680)2.51532968
123mitotic spindle checkpoint (GO:0071174)2.51331508
124regulation of cofactor metabolic process (GO:0051193)2.50968010
125regulation of coenzyme metabolic process (GO:0051196)2.50968010
126negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.50021986
127negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.50021986
128negative regulation of mitotic sister chromatid segregation (GO:0033048)2.50021986
129negative regulation of mitotic sister chromatid separation (GO:2000816)2.50021986
130negative regulation of sister chromatid segregation (GO:0033046)2.50021986
131kinetochore organization (GO:0051383)2.49905495
132regulation of mitotic sister chromatid segregation (GO:0033047)2.49782130
133regulation of sister chromatid segregation (GO:0033045)2.49782130
134regulation of mitotic sister chromatid separation (GO:0010965)2.49782130
135regulation of synapse structural plasticity (GO:0051823)2.48616022
136spindle assembly checkpoint (GO:0071173)2.48035692
137regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.47746268
138presynaptic membrane organization (GO:0097090)2.47190179
139negative regulation of protein activation cascade (GO:2000258)2.45962055
140regulation of neurotransmitter levels (GO:0001505)2.45735862
141CENP-A containing nucleosome assembly (GO:0034080)2.45651318
142positive regulation of Notch signaling pathway (GO:0045747)2.45387461
143positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.45221839
144regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.44962489
145mitotic spindle assembly checkpoint (GO:0007094)2.44331044
146negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.44317113
147protein K6-linked ubiquitination (GO:0085020)2.44119198
148cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.42993257
149cellular response to ethanol (GO:0071361)2.42127110
150succinate metabolic process (GO:0006105)2.40463442
151gamma-aminobutyric acid signaling pathway (GO:0007214)2.37881254
152detection of calcium ion (GO:0005513)2.34827495
153detection of temperature stimulus involved in sensory perception (GO:0050961)2.34006569
154detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.34006569
155L-phenylalanine catabolic process (GO:0006559)2.34004470
156erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.34004470
157regulation of vesicle fusion (GO:0031338)2.31886670
158forebrain neuron differentiation (GO:0021879)2.31799028
159cellular response to glucagon stimulus (GO:0071377)2.31742980
160neuron-neuron synaptic transmission (GO:0007270)2.31714822
161exploration behavior (GO:0035640)2.28928147
162synaptic transmission, glutamatergic (GO:0035249)2.28864338
163regulation of neuronal synaptic plasticity (GO:0048168)2.28116833
164coenzyme catabolic process (GO:0009109)2.25684879
165ionotropic glutamate receptor signaling pathway (GO:0035235)2.25168586
166negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.21586852
167regulation of excitatory postsynaptic membrane potential (GO:0060079)2.20770923
168regulation of synaptic transmission, glutamatergic (GO:0051966)2.20002504
169N-glycan processing (GO:0006491)2.19763296
170peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.18276646
171behavioral response to cocaine (GO:0048148)2.17651936
172cellular response to nitric oxide (GO:0071732)2.17643211
173regulation of voltage-gated calcium channel activity (GO:1901385)2.17387485
174regulation of autophagic vacuole assembly (GO:2000785)2.17292629
175energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.16602836
176ATP hydrolysis coupled proton transport (GO:0015991)2.16602836
177membrane depolarization during action potential (GO:0086010)2.16495926
178negative regulation of cation channel activity (GO:2001258)2.15312785
179synaptic vesicle endocytosis (GO:0048488)2.15205234
180dendrite morphogenesis (GO:0048813)2.14786252
181mating behavior (GO:0007617)2.14624562
182erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.14078658
183L-phenylalanine metabolic process (GO:0006558)2.14078658
184fatty acid elongation (GO:0030497)2.14026060
185oxaloacetate metabolic process (GO:0006107)2.13845650
186membrane assembly (GO:0071709)2.13209436
187positive regulation of membrane potential (GO:0045838)2.11414605
188cell morphogenesis involved in neuron differentiation (GO:0048667)2.11293969
189regulation of synaptic transmission, dopaminergic (GO:0032225)2.10790456
190positive regulation of cardiac muscle hypertrophy (GO:0010613)2.10540224
191positive regulation of muscle hypertrophy (GO:0014742)2.10540224
192acidic amino acid transport (GO:0015800)2.09871403
193regulation of long-term neuronal synaptic plasticity (GO:0048169)2.09816109
194positive regulation of macrophage differentiation (GO:0045651)2.08932095
195dicarboxylic acid catabolic process (GO:0043649)2.08386514
196sequestering of extracellular ligand from receptor (GO:0035581)2.07675144
197cerebellar Purkinje cell differentiation (GO:0021702)2.07455719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.33439044
2EZH2_22144423_ChIP-Seq_EOC_Human4.23742295
3E2F7_22180533_ChIP-Seq_HELA_Human3.96316235
4GBX2_23144817_ChIP-Seq_PC3_Human3.68434960
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91910424
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.89279667
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66938985
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60401681
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.48099112
10ELK1_19687146_ChIP-ChIP_HELA_Human2.41319632
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30620039
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25676354
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24952254
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23587698
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22731342
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.16206532
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15137572
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09255645
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09255645
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07063560
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06792399
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05273735
23CDX2_19796622_ChIP-Seq_MESCs_Mouse2.04185124
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00537239
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99441769
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99439478
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.95942008
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.95625984
29EWS_26573619_Chip-Seq_HEK293_Human1.94901668
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93584809
31TAF15_26573619_Chip-Seq_HEK293_Human1.91707474
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89607484
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.89242692
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.87844140
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77540181
36REST_21632747_ChIP-Seq_MESCs_Mouse1.76721560
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76014854
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74348363
39AR_21909140_ChIP-Seq_LNCAP_Human1.73006203
40DROSHA_22980978_ChIP-Seq_HELA_Human1.72652528
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72632064
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.69891015
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.69411237
44SMAD4_21799915_ChIP-Seq_A2780_Human1.67600271
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.67229889
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.65289944
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64589022
48REST_18959480_ChIP-ChIP_MESCs_Mouse1.62964075
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.62444469
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62217697
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.60228234
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57922739
53* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.56754559
54* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.56754559
55* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53471410
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52813856
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.52443351
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52115042
59IGF1R_20145208_ChIP-Seq_DFB_Human1.51087570
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50204228
61* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50042175
62GATA1_22025678_ChIP-Seq_K562_Human1.49247639
63ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49174695
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.48818123
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48092524
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46878049
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46814338
68AR_21572438_ChIP-Seq_LNCaP_Human1.43807644
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.43369047
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43175303
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42995644
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42253490
73P300_19829295_ChIP-Seq_ESCs_Human1.41336514
74* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40950514
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40400606
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40348992
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.40067805
78AR_25329375_ChIP-Seq_VCAP_Human1.39273359
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37469449
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36118587
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35111283
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.34807837
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34011712
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33338064
85* RARB_27405468_Chip-Seq_BRAIN_Mouse1.31275504
86CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30293414
87* BRD4_25478319_ChIP-Seq_HGPS_Human1.30114786
88* STAT3_23295773_ChIP-Seq_U87_Human1.29628715
89OCT4_21477851_ChIP-Seq_ESCs_Mouse1.29004845
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.28795215
91* SOX2_18555785_Chip-Seq_ESCs_Mouse1.28606512
92BCAT_22108803_ChIP-Seq_LS180_Human1.26422418
93SOX2_21211035_ChIP-Seq_LN229_Gbm1.24720553
94VDR_23849224_ChIP-Seq_CD4+_Human1.23788998
95TRIM28_21343339_ChIP-Seq_HEK293_Human1.23305661
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.23150970
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.22865603
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.22708189
99TP53_18474530_ChIP-ChIP_U2OS_Human1.20579235
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20554232
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19648573
102FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19096437
103* P300_18555785_Chip-Seq_ESCs_Mouse1.18423752
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18016095
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17441761
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17340174
107ZNF274_21170338_ChIP-Seq_K562_Hela1.17089463
108OCT4_18555785_Chip-Seq_ESCs_Mouse1.17063186
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17032163
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15924266
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15691208
112* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14524594
113ER_23166858_ChIP-Seq_MCF-7_Human1.14271966
114* NMYC_18555785_Chip-Seq_ESCs_Mouse1.13543989
115FOXM1_23109430_ChIP-Seq_U2OS_Human1.12947428
116* TCF4_23295773_ChIP-Seq_U87_Human1.10651618
117SMAD3_21741376_ChIP-Seq_EPCs_Human1.09110495
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08442618
119* ZFX_18555785_Chip-Seq_ESCs_Mouse1.07814368
120RUNX2_22187159_ChIP-Seq_PCA_Human1.07323858
121JUN_21703547_ChIP-Seq_K562_Human1.06775361
122RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06407357
123HTT_18923047_ChIP-ChIP_STHdh_Human1.05982560
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05176073
125CBP_20019798_ChIP-Seq_JUKART_Human1.05176073
126SRF_21415370_ChIP-Seq_HL-1_Mouse1.03479848
127ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03379287
128PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03150043
129NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01011146
130ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00993799
131KDM2B_26808549_Chip-Seq_REH_Human0.99406656
132CTCF_18555785_Chip-Seq_ESCs_Mouse0.99149131
133CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98705946
134* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98469254
135SMAD1_18555785_Chip-Seq_ESCs_Mouse0.97630789
136SOX17_20123909_ChIP-Seq_XEN_Mouse0.97418118
137FOXP3_21729870_ChIP-Seq_TREG_Human0.97033269
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96833436
139RXR_22158963_ChIP-Seq_LIVER_Mouse0.96217161
140LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96181040
141FUS_26573619_Chip-Seq_HEK293_Human0.94957444
142FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93607638
143TCF4_22108803_ChIP-Seq_LS180_Human0.91762880
144* NANOG_18555785_Chip-Seq_ESCs_Mouse0.91552633
145DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91124395
146ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90804758
147VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89526008
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89421130
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88997144
150* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88166745
151CJUN_26792858_Chip-Seq_BT549_Human0.87918567
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86320096
153* P53_22387025_ChIP-Seq_ESCs_Mouse0.85906634
154WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84003489
155* SOX2_19829295_ChIP-Seq_ESCs_Human0.83468120
156* NANOG_19829295_ChIP-Seq_ESCs_Human0.83468120
157* CMYC_18555785_Chip-Seq_ESCs_Mouse0.83066886
158PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81654773
159AR_19668381_ChIP-Seq_PC3_Human0.81600889
160PRDM14_20953172_ChIP-Seq_ESCs_Human0.81428561
161GATA2_21666600_ChIP-Seq_HMVEC_Human0.80757860

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell3.93649441
2MP0004859_abnormal_synaptic_plasticity3.42797993
3MP0009780_abnormal_chondrocyte_physiolo3.39841797
4MP0000372_irregular_coat_pigmentation3.27138221
5MP0008438_abnormal_cutaneous_collagen3.12649807
6MP0002102_abnormal_ear_morphology2.95436492
7MP0003880_abnormal_central_pattern2.76735718
8MP0002877_abnormal_melanocyte_morpholog2.76708762
9MP0003635_abnormal_synaptic_transmissio2.48463763
10MP0003787_abnormal_imprinting2.47228151
11MP0009046_muscle_twitch2.42434498
12MP0009697_abnormal_copulation2.41010527
13MP0010234_abnormal_vibrissa_follicle2.33566287
14MP0003329_amyloid_beta_deposits2.32752100
15MP0010094_abnormal_chromosome_stability2.24223847
16MP0000013_abnormal_adipose_tissue2.22346481
17MP0004270_analgesia2.21739469
18MP0000569_abnormal_digit_pigmentation2.21504165
19MP0010352_gastrointestinal_tract_polyps2.16486291
20MP0002064_seizures2.15014737
21MP0009745_abnormal_behavioral_response2.11691818
22MP0001968_abnormal_touch/_nociception2.08093092
23MP0006072_abnormal_retinal_apoptosis2.01315171
24MP0008058_abnormal_DNA_repair1.98606353
25MP0005084_abnormal_gallbladder_morpholo1.96771408
26MP0005408_hypopigmentation1.90362123
27MP0002736_abnormal_nociception_after1.83689891
28MP0010386_abnormal_urinary_bladder1.83082912
29MP0003111_abnormal_nucleus_morphology1.81480953
30MP0002272_abnormal_nervous_system1.81061463
31MP0002063_abnormal_learning/memory/cond1.78992670
32MP0005503_abnormal_tendon_morphology1.77957160
33MP0002734_abnormal_mechanical_nocicepti1.77472243
34MP0002876_abnormal_thyroid_physiology1.76696634
35MP0003300_gastrointestinal_ulcer1.70598721
36MP0003283_abnormal_digestive_organ1.69849612
37MP0002735_abnormal_chemical_nociception1.68085619
38MP0002938_white_spotting1.66914278
39MP0002572_abnormal_emotion/affect_behav1.66875297
40MP0003186_abnormal_redox_activity1.66248247
41MP0004957_abnormal_blastocyst_morpholog1.65524857
42MP0002909_abnormal_adrenal_gland1.64638779
43MP0002837_dystrophic_cardiac_calcinosis1.61651433
44MP0000604_amyloidosis1.61072842
45MP0008057_abnormal_DNA_replication1.61063358
46MP0002009_preneoplasia1.60825020
47MP0006276_abnormal_autonomic_nervous1.56445398
48MP0005360_urolithiasis1.55171860
49MP0001501_abnormal_sleep_pattern1.54393557
50MP0003806_abnormal_nucleotide_metabolis1.51401126
51MP0001661_extended_life_span1.49282736
52MP0002160_abnormal_reproductive_system1.47095959
53MP0004142_abnormal_muscle_tone1.46192792
54MP0000920_abnormal_myelination1.43819480
55MP0000751_myopathy1.43173198
56MP0002067_abnormal_sensory_capabilities1.42915309
57MP0003221_abnormal_cardiomyocyte_apopto1.42299384
58MP0005379_endocrine/exocrine_gland_phen1.41775296
59MP0002139_abnormal_hepatobiliary_system1.40835675
60MP0003786_premature_aging1.40247292
61MP0001970_abnormal_pain_threshold1.40235945
62MP0002733_abnormal_thermal_nociception1.40072828
63MP0005058_abnormal_lysosome_morphology1.37152148
64MP0001486_abnormal_startle_reflex1.36847636
65MP0006054_spinal_hemorrhage1.35685297
66MP0003941_abnormal_skin_development1.35003945
67MP0003690_abnormal_glial_cell1.34723061
68MP0003183_abnormal_peptide_metabolism1.34210285
69MP0003633_abnormal_nervous_system1.32993633
70MP0005646_abnormal_pituitary_gland1.30028577
71MP0008932_abnormal_embryonic_tissue1.26837344
72MP0003879_abnormal_hair_cell1.26687572
73MP0003172_abnormal_lysosome_physiology1.26583731
74MP0003718_maternal_effect1.26558395
75MP0004043_abnormal_pH_regulation1.25999940
76MP0003195_calcinosis1.24000326
77MP0002166_altered_tumor_susceptibility1.20947731
78MP0005174_abnormal_tail_pigmentation1.20792372
79MP0002163_abnormal_gland_morphology1.19970199
80MP0005075_abnormal_melanosome_morpholog1.18983113
81MP0003122_maternal_imprinting1.18299765
82MP0005275_abnormal_skin_tensile1.17391479
83MP0001440_abnormal_grooming_behavior1.17360383
84MP0002822_catalepsy1.17174497
85MP0005253_abnormal_eye_physiology1.16475793
86MP0003279_aneurysm1.14695951
87MP0005395_other_phenotype1.10760323
88MP0004084_abnormal_cardiac_muscle1.10747864
89MP0005645_abnormal_hypothalamus_physiol1.09955547
90MP0003950_abnormal_plasma_membrane1.09915167
91MP0004134_abnormal_chest_morphology1.09715497
92MP0000358_abnormal_cell_content/1.09463326
93MP0008007_abnormal_cellular_replicative1.07873767
94MP0005595_abnormal_vascular_smooth1.07272406
95MP0005389_reproductive_system_phenotype1.06254411
96MP0005623_abnormal_meninges_morphology1.04654965
97MP0001986_abnormal_taste_sensitivity1.04343479
98MP0003634_abnormal_glial_cell1.04248314
99MP0008877_abnormal_DNA_methylation1.03432281
100MP0005551_abnormal_eye_electrophysiolog1.02494954
101MP0008775_abnormal_heart_ventricle1.02256548
102MP0008004_abnormal_stomach_pH1.01188302
103MP0001944_abnormal_pancreas_morphology1.00221734
104MP0000371_diluted_coat_color1.00031329
105MP0002168_other_aberrant_phenotype0.98323295
106MP0008569_lethality_at_weaning0.98098344
107MP0003631_nervous_system_phenotype0.98039261
108MP0004858_abnormal_nervous_system0.97239788
109MP0000015_abnormal_ear_pigmentation0.95434928
110MP0002269_muscular_atrophy0.94785657
111MP0005187_abnormal_penis_morphology0.94515822
112MP0005332_abnormal_amino_acid0.94461476
113MP0002295_abnormal_pulmonary_circulatio0.93783525
114MP0002928_abnormal_bile_duct0.93663933
115MP0006036_abnormal_mitochondrial_physio0.93642786
116MP0004811_abnormal_neuron_physiology0.92851234
117MP0001177_atelectasis0.92039734
118MP0005085_abnormal_gallbladder_physiolo0.91512367
119MP0000343_altered_response_to0.91331569
120MP0010307_abnormal_tumor_latency0.90647759
121MP0001958_emphysema0.90280099
122MP0009384_cardiac_valve_regurgitation0.88911176
123MP0005171_absent_coat_pigmentation0.87694769
124MP0004742_abnormal_vestibular_system0.87533502
125MP0002066_abnormal_motor_capabilities/c0.87150064
126MP0010368_abnormal_lymphatic_system0.87102133
127MP0003252_abnormal_bile_duct0.86879703
128MP0001299_abnormal_eye_distance/0.86848312
129MP0005584_abnormal_enzyme/coenzyme_acti0.86670400
130MP0002060_abnormal_skin_morphology0.86467615
131MP0004924_abnormal_behavior0.86007685
132MP0005386_behavior/neurological_phenoty0.86007685
133MP0005248_abnormal_Harderian_gland0.85842389
134MP0005535_abnormal_body_temperature0.85781870
135MP0003077_abnormal_cell_cycle0.85507886
136MP0000003_abnormal_adipose_tissue0.85062556
137MP0005365_abnormal_bile_salt0.84779305
138MP0000747_muscle_weakness0.84561254
139MP0004272_abnormal_basement_membrane0.83888937
140MP0004215_abnormal_myocardial_fiber0.83047109
141MP0001905_abnormal_dopamine_level0.82407147
142MP0002006_tumorigenesis0.82298650
143MP0001984_abnormal_olfaction0.82259783
144MP0000230_abnormal_systemic_arterial0.82131926
145MP0001756_abnormal_urination0.81816622
146MP0002254_reproductive_system_inflammat0.81467620
147MP0003137_abnormal_impulse_conducting0.81127508
148MP0001542_abnormal_bone_strength0.80704358
149MP0002229_neurodegeneration0.80119012
150MP0000955_abnormal_spinal_cord0.79515208
151MP0008874_decreased_physiological_sensi0.79475378
152MP0002090_abnormal_vision0.79142989
153MP0005164_abnormal_response_to0.78382412
154MP0002069_abnormal_eating/drinking_beha0.77352054
155MP0003632_abnormal_nervous_system0.77346426
156MP0003045_fibrosis0.76867922
157MP0010329_abnormal_lipoprotein_level0.76521720
158MP0003011_delayed_dark_adaptation0.76373246
159MP0003075_altered_response_to0.76097624
160MP0000427_abnormal_hair_cycle0.74563864
161MP0005220_abnormal_exocrine_pancreas0.73320418
162MP0005636_abnormal_mineral_homeostasis0.71058656
163MP0004147_increased_porphyrin_level0.70918427
164MP0002234_abnormal_pharynx_morphology0.70175583
165MP0001243_abnormal_dermal_layer0.70071809
166MP0002177_abnormal_outer_ear0.68108929
167MP0004036_abnormal_muscle_relaxation0.66842513
168MP0004085_abnormal_heartbeat0.64703663
169MP0002693_abnormal_pancreas_physiology0.63786842
170MP0002751_abnormal_autonomic_nervous0.63736781
171MP0000647_abnormal_sebaceous_gland0.62629961
172MP0009250_abnormal_appendicular_skeleto0.62380478
173MP0003385_abnormal_body_wall0.62243053
174MP0003693_abnormal_embryo_hatching0.62218371
175MP0000639_abnormal_adrenal_gland0.59916421

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.20960383
2Hypoglycemic seizures (HP:0002173)3.68092367
3Progressive microcephaly (HP:0000253)3.67912796
4Hypoglycemic coma (HP:0001325)3.55466560
5Atonic seizures (HP:0010819)3.51673261
6Death in childhood (HP:0003819)3.51309807
7Pheochromocytoma (HP:0002666)3.48537015
8Overlapping toe (HP:0001845)3.28767771
9Neuroendocrine neoplasm (HP:0100634)3.25608295
10Myokymia (HP:0002411)3.21520976
11Hyperglycemia (HP:0003074)3.21144421
12Hepatosplenomegaly (HP:0001433)3.05588038
13Large for gestational age (HP:0001520)3.02768245
14Neurofibrillary tangles (HP:0002185)3.02355494
15Hyperinsulinemic hypoglycemia (HP:0000825)3.00222894
16Reduced subcutaneous adipose tissue (HP:0003758)2.99022783
17Focal seizures (HP:0007359)2.98721622
18Patchy hypopigmentation of hair (HP:0011365)2.93863500
19Visual hallucinations (HP:0002367)2.93467448
20Abnormal eating behavior (HP:0100738)2.91707930
21Volvulus (HP:0002580)2.89307068
22Premature rupture of membranes (HP:0001788)2.83451937
23Severe global developmental delay (HP:0011344)2.79064583
24Agitation (HP:0000713)2.67935886
25Renal cortical cysts (HP:0000803)2.56395197
26Cardiovascular calcification (HP:0011915)2.51223370
27Abnormality of chromosome stability (HP:0003220)2.50923880
28Generalized tonic-clonic seizures (HP:0002069)2.48996897
29Progressive macrocephaly (HP:0004481)2.48654680
30Mitral stenosis (HP:0001718)2.48374653
31Abnormality of aromatic amino acid family metabolism (HP:0004338)2.46400537
32Protrusio acetabuli (HP:0003179)2.46077012
33Intestinal atresia (HP:0011100)2.46060819
34Orthostatic hypotension (HP:0001278)2.45795859
35Hypobetalipoproteinemia (HP:0003563)2.42342902
36Muscle fiber atrophy (HP:0100295)2.40729803
37Hypothermia (HP:0002045)2.40568624
38Action tremor (HP:0002345)2.40100131
39Supranuclear gaze palsy (HP:0000605)2.38240290
40Cerebral inclusion bodies (HP:0100314)2.37985648
41Absence seizures (HP:0002121)2.37967094
42Symptomatic seizures (HP:0011145)2.37042314
43Pancreatic islet-cell hyperplasia (HP:0004510)2.36395505
44Proximal tubulopathy (HP:0000114)2.34238541
45Adrenal hypoplasia (HP:0000835)2.26671110
46Spondylolisthesis (HP:0003302)2.25405154
47Cutaneous melanoma (HP:0012056)2.24393769
48Vascular calcification (HP:0004934)2.23683700
49Torticollis (HP:0000473)2.23263505
50Methylmalonic acidemia (HP:0002912)2.22857468
51Hypoplasia of the fovea (HP:0007750)2.22802935
52Aplasia/Hypoplasia of the fovea (HP:0008060)2.22802935
53Abnormality of dentin (HP:0010299)2.21764361
54Increased hepatocellular lipid droplets (HP:0006565)2.21026504
55Anxiety (HP:0000739)2.19047373
56Papilledema (HP:0001085)2.19035623
57Dysostosis multiplex (HP:0000943)2.17084889
58Increased cerebral lipofuscin (HP:0011813)2.16419874
59Prominent nose (HP:0000448)2.14364506
60Abnormality of the fovea (HP:0000493)2.13886713
61Polyphagia (HP:0002591)2.13652793
62Thickened helices (HP:0000391)2.13425756
63Craniofacial dystonia (HP:0012179)2.12883268
64Hypokinesia (HP:0002375)2.12741543
65Medial flaring of the eyebrow (HP:0010747)2.12438683
66Focal dystonia (HP:0004373)2.12413090
67Oligomenorrhea (HP:0000876)2.12340918
68Deep philtrum (HP:0002002)2.11873932
69Abnormality of vitamin B metabolism (HP:0004340)2.11703330
70Abnormality of methionine metabolism (HP:0010901)2.10254458
71Depression (HP:0000716)2.08985320
72Epileptic encephalopathy (HP:0200134)2.07260666
73Hypoventilation (HP:0002791)2.06457589
74Acute encephalopathy (HP:0006846)2.05802039
75Deep venous thrombosis (HP:0002625)2.05271712
76Febrile seizures (HP:0002373)2.05041096
77Increased CSF lactate (HP:0002490)2.04662503
78Dialeptic seizures (HP:0011146)2.04635620
79Progressive cerebellar ataxia (HP:0002073)2.04494734
80Postural tremor (HP:0002174)2.02601792
81Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.02598533
82Protuberant abdomen (HP:0001538)2.02095315
83Palpitations (HP:0001962)2.02069481
84Cerebral edema (HP:0002181)1.99941181
85Increased neuronal autofluorescent lipopigment (HP:0002074)1.98827605
86Polygenic inheritance (HP:0010982)1.98459853
87Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98414136
88Mucopolysacchariduria (HP:0008155)1.97915289
89Urinary glycosaminoglycan excretion (HP:0003541)1.97915289
90Resting tremor (HP:0002322)1.96643677
91Generalized myoclonic seizures (HP:0002123)1.96563883
92Gastrointestinal atresia (HP:0002589)1.96045138
93Hemorrhage of the eye (HP:0011885)1.94954974
94Cerebral hemorrhage (HP:0001342)1.94815732
95Abnormality of macular pigmentation (HP:0008002)1.92572413
96Increased serum pyruvate (HP:0003542)1.92468391
97Scanning speech (HP:0002168)1.92460357
98Metaphyseal dysplasia (HP:0100255)1.91853916
99Abnormal mitochondria in muscle tissue (HP:0008316)1.91427802
100Porencephaly (HP:0002132)1.91360976
101Increased variability in muscle fiber diameter (HP:0003557)1.91158157
102Gaze-evoked nystagmus (HP:0000640)1.90765351
103Impaired vibration sensation in the lower limbs (HP:0002166)1.90735533
104Ankle contracture (HP:0006466)1.90561660
105Beaking of vertebral bodies (HP:0004568)1.89952638
106Ankle clonus (HP:0011448)1.89398276
107Skin nodule (HP:0200036)1.89351840
108Abnormality of vitamin metabolism (HP:0100508)1.89179813
109Hepatic necrosis (HP:0002605)1.88396153
110Delayed gross motor development (HP:0002194)1.88215457
111Atrioventricular block (HP:0001678)1.87991823
112Mesomelia (HP:0003027)1.86228085
113Abnormality of the renal cortex (HP:0011035)1.86201478
114Abnormal biliary tract morphology (HP:0012440)1.86136621
115Neuronal loss in central nervous system (HP:0002529)1.85858190
116Chronic otitis media (HP:0000389)1.83607016
117Congenital primary aphakia (HP:0007707)1.83147990
118Lipid accumulation in hepatocytes (HP:0006561)1.82019856
119Shawl scrotum (HP:0000049)1.81655594
120Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81181479
121Abnormality of chromosome segregation (HP:0002916)1.80193626
122Gout (HP:0001997)1.79825192
123Mitochondrial inheritance (HP:0001427)1.79770436
124Ketoacidosis (HP:0001993)1.79066042
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78670611
126Abnormal protein N-linked glycosylation (HP:0012347)1.78670611
127Abnormal protein glycosylation (HP:0012346)1.78670611
128Abnormal glycosylation (HP:0012345)1.78670611
129Type I transferrin isoform profile (HP:0003642)1.77568236
130Abnormality of the astrocytes (HP:0100707)1.77007059
131Astrocytoma (HP:0009592)1.77007059
132Abnormal gallbladder morphology (HP:0012437)1.76702784
133Spinal canal stenosis (HP:0003416)1.76427370
134Insidious onset (HP:0003587)1.76264901
135Termporal pattern (HP:0011008)1.76264901
136Dysmetria (HP:0001310)1.76226458
137Akinesia (HP:0002304)1.76066148
138Abnormality of the intrinsic pathway (HP:0010989)1.75328300
139Plagiocephaly (HP:0001357)1.75099958
140Abnormality of calcium-phosphate metabolism (HP:0100530)1.74660929
141J-shaped sella turcica (HP:0002680)1.74655831
142Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73362196
143Abnormality of polysaccharide metabolism (HP:0011012)1.73362196
144Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73362196
145Myotonia (HP:0002486)1.73007752
146Infantile muscular hypotonia (HP:0008947)1.72579231
147Abnormality of pain sensation (HP:0010832)1.72529299
148Impaired pain sensation (HP:0007328)1.72529299
149Hamartoma of the eye (HP:0010568)1.72281627
150Long toe (HP:0010511)1.71878039
151Abnormality of the common coagulation pathway (HP:0010990)1.71754132
152Abnormal pupillary function (HP:0007686)1.71496690
153Abnormality of glycolysis (HP:0004366)1.71471208
154Abnormal gallbladder physiology (HP:0012438)1.71442696
155Cholecystitis (HP:0001082)1.71442696
156Renal Fanconi syndrome (HP:0001994)1.71048256
157Abnormality of the pancreatic islet cells (HP:0006476)1.70600726
158Abnormality of endocrine pancreas physiology (HP:0012093)1.70600726
159Retinal atrophy (HP:0001105)1.70490114
160Upper limb muscle weakness (HP:0003484)1.69815902
161Acute necrotizing encephalopathy (HP:0006965)1.69732415
162Vertebral compression fractures (HP:0002953)1.69623960
163Hemiplegia (HP:0002301)1.69459058
164Elbow flexion contracture (HP:0002987)1.69193032
165Glioma (HP:0009733)1.68789763
166Insulin-resistant diabetes mellitus (HP:0000831)1.68614415
167Increased circulating renin level (HP:0000848)1.68535548
168Chromsome breakage (HP:0040012)1.68441857
169Glucose intolerance (HP:0000833)1.67965942
170Cortical visual impairment (HP:0100704)1.67777697
171Short tibia (HP:0005736)1.67724319
172Thyroid carcinoma (HP:0002890)1.67451027
173Poor suck (HP:0002033)1.67308436
174Tongue fasciculations (HP:0001308)1.67262055
175Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.66918721
176Blue irides (HP:0000635)1.66439538
177Xanthomatosis (HP:0000991)1.66018981
178Hepatocellular necrosis (HP:0001404)1.65605855
179Abnormality of the fetal cardiovascular system (HP:0010948)1.64631100
180Abnormal umbilical cord blood vessels (HP:0011403)1.64631100
181Single umbilical artery (HP:0001195)1.64631100
182Peritonitis (HP:0002586)1.64325058
183Nervous tissue neoplasm (HP:0030060)1.64219424
184Neuroectodermal neoplasm (HP:0030061)1.64219424
185Neuroepithelial neoplasm (HP:0030063)1.64219424
186Hyperlipoproteinemia (HP:0010980)1.64024209
187Dysdiadochokinesis (HP:0002075)1.63660181
188Sensory axonal neuropathy (HP:0003390)1.62696987
189Secondary amenorrhea (HP:0000869)1.60895600
190Gait imbalance (HP:0002141)1.60772396
191Ependymoma (HP:0002888)1.59251632

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K45.41079977
2MAP2K75.30496345
3MAP3K64.14962380
4MAP2K43.68319154
5MAP3K123.57648221
6MST43.27032194
7FRK2.99822124
8NTRK32.87592045
9EIF2AK12.85300411
10TRIM282.71988909
11ERBB32.61689480
12PLK32.14520418
13BRSK22.11268788
14NEK12.10848911
15CAMKK22.09302230
16PBK2.07819669
17BUB12.06278302
18CASK2.06182262
19NUAK12.04993967
20PRPF4B2.02478962
21NTRK11.95300888
22TNIK1.78764971
23MAP4K21.77395255
24WEE11.70793772
25CLK11.68031668
26MINK11.66522605
27RET1.64365844
28TTK1.59212925
29MAPK131.56535003
30TSSK61.56422811
31CAMKK11.47258896
32PNCK1.46523319
33EPHA41.44436796
34STK31.43836293
35EIF2AK21.43190189
36WNK41.40617915
37FES1.34287989
38PLK21.33090723
39CSNK1G21.32365215
40CSNK1G31.32013507
41PLK41.31934657
42PDK21.28259636
43ACVR1B1.24497421
44MKNK21.22554424
45CDK151.22308614
46BMPR1B1.22307812
47CDK51.22265377
48CDK181.21358115
49STK101.21095370
50STK391.17513140
51PRKCH1.14785044
52OXSR11.14279475
53CSNK1A1L1.14174657
54CDK191.14009419
55CDK141.13794411
56CCNB11.10158056
57MKNK11.08660429
58CDC71.06642527
59CDK11A1.06577745
60SRPK11.06489417
61SCYL21.04821604
62ADRBK11.04571603
63STK161.04470925
64PRKCG1.00837756
65GRK51.00528563
66ZAK1.00414584
67DAPK21.00106136
68PLK10.99527332
69FER0.99344744
70NEK90.93382191
71WNK10.92766251
72CDK60.91297366
73MAP3K50.90738531
74TRPM70.90181845
75MAPKAPK50.89151983
76CSNK1G10.88982644
77PAK30.88814585
78DDR20.88637233
79ERBB40.87034882
80PHKG20.86203616
81PHKG10.86203616
82STK38L0.85391491
83EPHB10.83570512
84MAP3K20.82978564
85MAPK40.80747459
86PTK20.80613580
87BRSK10.79542236
88PAK60.79503592
89STK240.78718893
90RIPK40.78708160
91MAP3K10.73822443
92WNK30.73388356
93PTK2B0.72128595
94PRKCE0.71406105
95STK40.71253959
96MAP3K90.69114927
97VRK10.68255854
98CAMK2A0.65598740
99MYLK0.65449611
100JAK10.61045220
101FGFR20.60841104
102SGK4940.60539302
103SGK2230.60539302
104KSR20.59925122
105ATM0.59826035
106ILK0.59324683
107CAMK2D0.58087333
108UHMK10.56349302
109MOS0.56266267
110CDK90.54161759
111LIMK10.52987464
112EPHA30.52923830
113PRKD30.52711158
114GRK70.51858233
115AKT30.50184281
116TIE10.49805848
117DAPK10.49698135
118MET0.49623550
119MARK10.49174505
120PINK10.49029239
121MST1R0.48381190
122CAMK2B0.48081460
123FYN0.46770869
124LATS10.45484438
125TAOK30.45428648
126BMPR20.44811767
127ROCK20.44132492
128PAK40.43990249
129SIK30.43923518
130SIK10.43662254
131BCR0.43427161
132ABL20.42651792
133RAF10.42346017
134MUSK0.41335983
135CDK30.41228462
136PDK10.40882826
137AURKB0.40829641
138FLT30.40558647
139ADRBK20.37306921
140MARK30.37139760
141TGFBR20.37138653
142SGK20.36973648
143IGF1R0.36290936
144CHEK20.36090692
145ROCK10.36057990
146GRK10.34787710
147KSR10.34698053
148MAP2K10.33735789
149DMPK0.33528302
150YES10.33453850
151CDC42BPA0.33309228
152CAMK10.33232595
153PIK3CG0.33227943
154PDPK10.32229813
155CAMK1G0.32092394
156EIF2AK30.31243103
157TTN0.29163499
158PRKCA0.29102964
159TNK20.28709268
160CAMK2G0.27708937
161CDK80.26665788
162PRKG10.26397357
163PRKACA0.26385332
164SGK30.26099619

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.23151698
2Proteasome_Homo sapiens_hsa030502.87929213
3Synaptic vesicle cycle_Homo sapiens_hsa047212.84213890
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33572602
5Nicotine addiction_Homo sapiens_hsa050332.26621062
6GABAergic synapse_Homo sapiens_hsa047272.17851546
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10675783
8Selenocompound metabolism_Homo sapiens_hsa004502.04736350
9Vibrio cholerae infection_Homo sapiens_hsa051101.91230762
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90764773
11Morphine addiction_Homo sapiens_hsa050321.86219175
12Circadian entrainment_Homo sapiens_hsa047131.85140597
13Basal transcription factors_Homo sapiens_hsa030221.84534420
14Collecting duct acid secretion_Homo sapiens_hsa049661.82461494
15Folate biosynthesis_Homo sapiens_hsa007901.80072946
16Protein export_Homo sapiens_hsa030601.76496831
17Insulin secretion_Homo sapiens_hsa049111.76050897
18Nitrogen metabolism_Homo sapiens_hsa009101.70973441
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65227851
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61530031
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56321589
22Olfactory transduction_Homo sapiens_hsa047401.55277164
23Sulfur metabolism_Homo sapiens_hsa009201.55267666
24One carbon pool by folate_Homo sapiens_hsa006701.54240192
25Butanoate metabolism_Homo sapiens_hsa006501.52411846
26Dopaminergic synapse_Homo sapiens_hsa047281.50612449
27Glutamatergic synapse_Homo sapiens_hsa047241.50271193
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.49975806
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49895715
30Vitamin B6 metabolism_Homo sapiens_hsa007501.48267351
31Homologous recombination_Homo sapiens_hsa034401.45711722
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.43275145
33* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42840465
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41340584
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40519360
36Amphetamine addiction_Homo sapiens_hsa050311.40206694
37Fatty acid elongation_Homo sapiens_hsa000621.36085980
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32599159
39Phagosome_Homo sapiens_hsa041451.32559730
40Mismatch repair_Homo sapiens_hsa034301.31623141
41Long-term depression_Homo sapiens_hsa047301.31140215
42Salivary secretion_Homo sapiens_hsa049701.27116723
43Cocaine addiction_Homo sapiens_hsa050301.26316632
44Fanconi anemia pathway_Homo sapiens_hsa034601.22326827
45Renin secretion_Homo sapiens_hsa049241.21124287
46Serotonergic synapse_Homo sapiens_hsa047261.20378416
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19079727
48Long-term potentiation_Homo sapiens_hsa047201.18828849
49RNA polymerase_Homo sapiens_hsa030201.18346734
50RNA degradation_Homo sapiens_hsa030181.17529647
51Lysosome_Homo sapiens_hsa041421.17096350
52Cell cycle_Homo sapiens_hsa041101.16989013
53Taste transduction_Homo sapiens_hsa047421.16106610
54Oxidative phosphorylation_Homo sapiens_hsa001901.15199577
55Cholinergic synapse_Homo sapiens_hsa047251.15146083
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09533304
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09358876
58Type II diabetes mellitus_Homo sapiens_hsa049301.09322912
59Oocyte meiosis_Homo sapiens_hsa041141.08752313
60RNA transport_Homo sapiens_hsa030131.06373124
61Arginine biosynthesis_Homo sapiens_hsa002201.04962800
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03706521
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03392836
64Alzheimers disease_Homo sapiens_hsa050101.01888907
65Gastric acid secretion_Homo sapiens_hsa049710.99971434
66Pyruvate metabolism_Homo sapiens_hsa006200.99811320
67Glutathione metabolism_Homo sapiens_hsa004800.97788140
68Nucleotide excision repair_Homo sapiens_hsa034200.96743440
69Complement and coagulation cascades_Homo sapiens_hsa046100.96103068
70Purine metabolism_Homo sapiens_hsa002300.95595958
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95540010
72Regulation of autophagy_Homo sapiens_hsa041400.95164495
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94996956
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93764079
75Thyroid hormone synthesis_Homo sapiens_hsa049180.91260185
76GnRH signaling pathway_Homo sapiens_hsa049120.89887879
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.89370956
78Calcium signaling pathway_Homo sapiens_hsa040200.88434477
79Circadian rhythm_Homo sapiens_hsa047100.88261941
80Fatty acid metabolism_Homo sapiens_hsa012120.87701162
81p53 signaling pathway_Homo sapiens_hsa041150.86939582
82Bile secretion_Homo sapiens_hsa049760.85706706
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85705434
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85388366
85DNA replication_Homo sapiens_hsa030300.82134972
86Pyrimidine metabolism_Homo sapiens_hsa002400.82100911
87N-Glycan biosynthesis_Homo sapiens_hsa005100.81717029
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81061683
89Rheumatoid arthritis_Homo sapiens_hsa053230.79251223
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.78544584
91cAMP signaling pathway_Homo sapiens_hsa040240.78157258
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77832268
93Peroxisome_Homo sapiens_hsa041460.74522912
94Prion diseases_Homo sapiens_hsa050200.74194857
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73719845
96Fatty acid degradation_Homo sapiens_hsa000710.73444910
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.72747582
98Parkinsons disease_Homo sapiens_hsa050120.72312957
99ECM-receptor interaction_Homo sapiens_hsa045120.72200889
100* Metabolic pathways_Homo sapiens_hsa011000.71265914
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71077485
102Carbon metabolism_Homo sapiens_hsa012000.70413260
103Propanoate metabolism_Homo sapiens_hsa006400.70152466
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69424409
105Dilated cardiomyopathy_Homo sapiens_hsa054140.69202471
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68844480
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68297320
108Gap junction_Homo sapiens_hsa045400.68154697
109Sphingolipid metabolism_Homo sapiens_hsa006000.67303465
110Malaria_Homo sapiens_hsa051440.67281281
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66241326
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66220947
113Oxytocin signaling pathway_Homo sapiens_hsa049210.65952780
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65574839
115Tryptophan metabolism_Homo sapiens_hsa003800.65372408
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63843451
117Glioma_Homo sapiens_hsa052140.63738159
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63406019
119Huntingtons disease_Homo sapiens_hsa050160.62827059
120Phototransduction_Homo sapiens_hsa047440.61677412
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61636655
122Type I diabetes mellitus_Homo sapiens_hsa049400.60902190
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60631497
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59386345
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59281709
126TGF-beta signaling pathway_Homo sapiens_hsa043500.59112393
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56214443
128Histidine metabolism_Homo sapiens_hsa003400.54583090
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.54208792
130Estrogen signaling pathway_Homo sapiens_hsa049150.52296651
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.51406748
132Retinol metabolism_Homo sapiens_hsa008300.49537267
133Spliceosome_Homo sapiens_hsa030400.49057647
134Ovarian steroidogenesis_Homo sapiens_hsa049130.48004601
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47659249
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47028509
137Mineral absorption_Homo sapiens_hsa049780.45664855
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45625215
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45362476
140Steroid biosynthesis_Homo sapiens_hsa001000.44856399
141Cardiac muscle contraction_Homo sapiens_hsa042600.43347126
142beta-Alanine metabolism_Homo sapiens_hsa004100.42127496
143Starch and sucrose metabolism_Homo sapiens_hsa005000.41290077
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40963261
145Glucagon signaling pathway_Homo sapiens_hsa049220.40092014
146Tyrosine metabolism_Homo sapiens_hsa003500.39656741
147Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39423607
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39108695
149ABC transporters_Homo sapiens_hsa020100.39084853
150Other glycan degradation_Homo sapiens_hsa005110.38309683
151Inositol phosphate metabolism_Homo sapiens_hsa005620.38236268
152Arginine and proline metabolism_Homo sapiens_hsa003300.34067591
153Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33691530
154Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33426698
155Ether lipid metabolism_Homo sapiens_hsa005650.31607411
156Protein digestion and absorption_Homo sapiens_hsa049740.31270773
157Fatty acid biosynthesis_Homo sapiens_hsa000610.30854542

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