PIGM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial respiratory chain complex I assembly (GO:0032981)5.23025423
2NADH dehydrogenase complex assembly (GO:0010257)5.23025423
3mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.23025423
4DNA deamination (GO:0045006)4.85517127
5protein complex biogenesis (GO:0070271)4.70788268
6nuclear pore complex assembly (GO:0051292)4.57486055
7mitochondrial respiratory chain complex assembly (GO:0033108)4.44373679
8nuclear pore organization (GO:0006999)4.16043434
9branching involved in labyrinthine layer morphogenesis (GO:0060670)3.90746307
10mitotic sister chromatid cohesion (GO:0007064)3.88234324
11behavioral response to nicotine (GO:0035095)3.74572435
12pore complex assembly (GO:0046931)3.65297680
13water-soluble vitamin biosynthetic process (GO:0042364)3.63769967
14positive regulation of mitochondrial fission (GO:0090141)3.55791111
15tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54159744
16RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54159744
17pre-miRNA processing (GO:0031054)3.40879088
18definitive hemopoiesis (GO:0060216)3.39410952
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.37709487
20kynurenine metabolic process (GO:0070189)3.36705213
21* mannosylation (GO:0097502)3.35870921
22peptidyl-histidine modification (GO:0018202)3.33275226
23exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33188509
24nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31949018
25* preassembly of GPI anchor in ER membrane (GO:0016254)3.31463182
26kinetochore organization (GO:0051383)3.26213602
27sulfation (GO:0051923)3.26025169
28negative regulation of telomere maintenance (GO:0032205)3.24453518
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.19865143
30indole-containing compound catabolic process (GO:0042436)3.18369910
31indolalkylamine catabolic process (GO:0046218)3.18369910
32tryptophan catabolic process (GO:0006569)3.18369910
33GPI anchor metabolic process (GO:0006505)3.17895728
34meiotic chromosome segregation (GO:0045132)3.15293367
35regulation of DNA endoreduplication (GO:0032875)3.13912283
36positive regulation of oligodendrocyte differentiation (GO:0048714)3.10122084
37pseudouridine synthesis (GO:0001522)3.09414571
38regulation of histone H3-K9 methylation (GO:0051570)3.08976846
39rRNA modification (GO:0000154)3.08577352
40DNA unwinding involved in DNA replication (GO:0006268)3.08201857
41positive regulation of gamma-delta T cell activation (GO:0046645)3.07686628
42replication fork processing (GO:0031297)3.07480984
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.06741649
44energy coupled proton transport, down electrochemical gradient (GO:0015985)3.06303176
45ATP synthesis coupled proton transport (GO:0015986)3.06303176
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.04772851
47histone mRNA catabolic process (GO:0071044)3.02003273
48indolalkylamine metabolic process (GO:0006586)3.01532423
49protein-cofactor linkage (GO:0018065)3.01271066
50mitochondrion morphogenesis (GO:0070584)2.99014557
51establishment of protein localization to mitochondrial membrane (GO:0090151)2.98765690
52regulation of mitochondrial translation (GO:0070129)2.98158401
53DNA double-strand break processing (GO:0000729)2.97780393
54negative regulation of mast cell activation (GO:0033004)2.96481984
55positive regulation of prostaglandin secretion (GO:0032308)2.96331417
56respiratory chain complex IV assembly (GO:0008535)2.95609479
57fucose catabolic process (GO:0019317)2.95469526
58L-fucose metabolic process (GO:0042354)2.95469526
59L-fucose catabolic process (GO:0042355)2.95469526
60chaperone-mediated protein transport (GO:0072321)2.92979417
61interferon-gamma production (GO:0032609)2.90432883
62seminiferous tubule development (GO:0072520)2.89839344
63synapsis (GO:0007129)2.89536650
64tryptophan metabolic process (GO:0006568)2.88113236
65base-excision repair, AP site formation (GO:0006285)2.84265817
66CENP-A containing nucleosome assembly (GO:0034080)2.84006439
67iron-sulfur cluster assembly (GO:0016226)2.83799841
68metallo-sulfur cluster assembly (GO:0031163)2.83799841
69reciprocal meiotic recombination (GO:0007131)2.83248245
70reciprocal DNA recombination (GO:0035825)2.83248245
71DNA replication initiation (GO:0006270)2.83017017
72tRNA processing (GO:0008033)2.82492696
73serine family amino acid catabolic process (GO:0009071)2.78184284
74IMP biosynthetic process (GO:0006188)2.77493137
75positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.76173915
76negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.73540919
77regulation of RNA export from nucleus (GO:0046831)2.73258879
78GPI anchor biosynthetic process (GO:0006506)2.72272798
79mitochondrial RNA metabolic process (GO:0000959)2.71357198
80tRNA modification (GO:0006400)2.71262047
81negative regulation of translation, ncRNA-mediated (GO:0040033)2.71044193
82regulation of translation, ncRNA-mediated (GO:0045974)2.71044193
83negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.71044193
84chromatin remodeling at centromere (GO:0031055)2.70867757
85mitotic nuclear envelope disassembly (GO:0007077)2.69744478
86kinetochore assembly (GO:0051382)2.69322223
87pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.68796117
88metaphase plate congression (GO:0051310)2.67847296
89DNA replication-independent nucleosome assembly (GO:0006336)2.66540259
90DNA replication-independent nucleosome organization (GO:0034724)2.66540259
91DNA topological change (GO:0006265)2.66282894
92recombinational repair (GO:0000725)2.65246603
93L-methionine biosynthetic process (GO:0071265)2.64018439
94amino acid salvage (GO:0043102)2.64018439
95L-methionine salvage (GO:0071267)2.64018439
96cytochrome complex assembly (GO:0017004)2.63782499
97double-strand break repair via homologous recombination (GO:0000724)2.63314338
983-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.62007607
99purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.62007607
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.61889512
101termination of RNA polymerase III transcription (GO:0006386)2.61889512
102spindle assembly involved in mitosis (GO:0090307)2.61754351
103rRNA methylation (GO:0031167)2.61031937
104protein localization to chromosome, centromeric region (GO:0071459)2.60850601
105estrogen biosynthetic process (GO:0006703)2.60242344
106maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.59916100
107mitotic recombination (GO:0006312)2.57397616
108ubiquinone biosynthetic process (GO:0006744)2.55946924
109cellular ketone body metabolic process (GO:0046950)2.55555285
110negative regulation of telomerase activity (GO:0051974)2.55304833
111monoubiquitinated protein deubiquitination (GO:0035520)2.54655476
112mitotic metaphase plate congression (GO:0007080)2.54523115
113DNA geometric change (GO:0032392)2.53104419
114electron transport chain (GO:0022900)2.53000510
115regulation of helicase activity (GO:0051095)2.52698076
116DNA duplex unwinding (GO:0032508)2.52541033
117mismatch repair (GO:0006298)2.52505609
118glycine metabolic process (GO:0006544)2.51890545
119protein localization to kinetochore (GO:0034501)2.51379196
120snRNA processing (GO:0016180)2.51059120
121respiratory electron transport chain (GO:0022904)2.50968981
122telomere maintenance via recombination (GO:0000722)2.50384191
123negative regulation of cell cycle arrest (GO:0071157)2.50345120
124resolution of meiotic recombination intermediates (GO:0000712)2.50238408
125adenosine metabolic process (GO:0046085)2.49873756
126somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.49578790
127isotype switching (GO:0045190)2.49578790
128somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.49578790
129regulation of spindle organization (GO:0090224)2.48527521
130regulation of mitochondrial fission (GO:0090140)2.47497747
131nucleotide transmembrane transport (GO:1901679)2.47137187
132telomere maintenance via semi-conservative replication (GO:0032201)2.46632075
133DNA synthesis involved in DNA repair (GO:0000731)2.46269873
134detection of light stimulus involved in visual perception (GO:0050908)2.45946964
135detection of light stimulus involved in sensory perception (GO:0050962)2.45946964
136epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.45562363
137gamma-aminobutyric acid transport (GO:0015812)2.45345980
138prostate gland growth (GO:0060736)2.44230197
139aggressive behavior (GO:0002118)2.43644367
140regulation of nuclear cell cycle DNA replication (GO:0033262)2.43408144
141antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.43396833
142negative T cell selection (GO:0043383)2.43355262
143ubiquinone metabolic process (GO:0006743)2.42955495
144regulation of mitotic spindle checkpoint (GO:1903504)2.42339795
145regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.42339795
146nuclear envelope disassembly (GO:0051081)2.42148278
147membrane disassembly (GO:0030397)2.42148278
148sister chromatid cohesion (GO:0007062)2.42039430
149dosage compensation (GO:0007549)2.41514697
150negative regulation of histone methylation (GO:0031061)2.41441489
151mitotic chromosome condensation (GO:0007076)2.39972254
152V(D)J recombination (GO:0033151)2.39850868
153DNA strand elongation involved in DNA replication (GO:0006271)2.39595597
154sister chromatid segregation (GO:0000819)2.39591554
155histone exchange (GO:0043486)2.39271373
156nucleobase biosynthetic process (GO:0046112)2.37902008
157purine nucleobase biosynthetic process (GO:0009113)2.36891296
158DNA strand elongation (GO:0022616)2.36662469
159translesion synthesis (GO:0019985)2.36565517
160positive regulation of mitotic sister chromatid separation (GO:1901970)2.36495648
161positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.36495648
162positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.36495648
163negative regulation of DNA-dependent DNA replication (GO:2000104)2.35636784
164chromatin assembly or disassembly (GO:0006333)2.35224558
165establishment of chromosome localization (GO:0051303)2.33857410
166snRNA metabolic process (GO:0016073)2.32448416
167regulation of interleukin-12 biosynthetic process (GO:0045075)2.31629064
168DNA conformation change (GO:0071103)2.27560503
169regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.27320150
170negative thymic T cell selection (GO:0045060)2.26326690
171negative regulation of phagocytosis (GO:0050765)2.26042711
172negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.25764683
173positive regulation of chromosome segregation (GO:0051984)2.25342271
174IMP metabolic process (GO:0046040)2.23145725
175regulation of gamma-delta T cell activation (GO:0046643)2.22772770
176myeloid dendritic cell activation (GO:0001773)2.22356996
177negative regulation of RNA splicing (GO:0033119)2.21453965
178ATP-dependent chromatin remodeling (GO:0043044)2.19583352
179attachment of spindle microtubules to kinetochore (GO:0008608)2.19480156
180megakaryocyte development (GO:0035855)2.18996924
181nucleotide-excision repair, DNA gap filling (GO:0006297)2.18782951
182gene silencing by RNA (GO:0031047)2.18096841
183somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.16181959
184somatic cell DNA recombination (GO:0016444)2.16181959
185neural tube formation (GO:0001841)2.15586780
186regulation of gamma-delta T cell differentiation (GO:0045586)2.15586573
187intra-S DNA damage checkpoint (GO:0031573)2.15275589
188telomere maintenance via telomere lengthening (GO:0010833)2.13455950
189NIK/NF-kappaB signaling (GO:0038061)2.13422948
190cytoplasmic mRNA processing body assembly (GO:0033962)2.12981519
191somatic hypermutation of immunoglobulin genes (GO:0016446)2.12315984
192somatic diversification of immune receptors via somatic mutation (GO:0002566)2.12315984
193negative regulation of mRNA processing (GO:0050686)2.12096127
194peptidyl-lysine trimethylation (GO:0018023)2.12073941
195protein K6-linked ubiquitination (GO:0085020)2.12064850
196histone H3-K4 trimethylation (GO:0080182)2.11792994
197histone H3-K9 methylation (GO:0051567)2.11070653
198telomere maintenance (GO:0000723)2.10649254
199RNA stabilization (GO:0043489)2.09878224

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.97146458
2ZNF274_21170338_ChIP-Seq_K562_Hela3.86588113
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.81208066
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.80394219
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.53346270
6* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.42187253
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.23529611
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.06737650
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.84246727
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75564689
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62725150
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.44706454
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.41209238
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.38956319
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35610909
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33700749
17FUS_26573619_Chip-Seq_HEK293_Human2.30573529
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29682584
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27254650
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.27005599
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.26183307
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.23653197
23IRF1_19129219_ChIP-ChIP_H3396_Human2.20127275
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.18890754
25IGF1R_20145208_ChIP-Seq_DFB_Human2.17731545
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.16284492
27EZH2_22144423_ChIP-Seq_EOC_Human2.15033647
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12590161
29VDR_22108803_ChIP-Seq_LS180_Human2.12436304
30GBX2_23144817_ChIP-Seq_PC3_Human2.11063545
31TAF15_26573619_Chip-Seq_HEK293_Human2.04025995
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.03665319
33ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03661190
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01600718
35E2F7_22180533_ChIP-Seq_HELA_Human10.0572425
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.98363641
37MYC_22102868_ChIP-Seq_BL_Human1.92049882
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88690717
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87536421
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82575487
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81154708
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79726815
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.78222686
44ELK1_19687146_ChIP-ChIP_HELA_Human1.77433773
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77311057
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76893545
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.74091392
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64464029
49AR_21909140_ChIP-Seq_LNCAP_Human1.63639950
50ER_23166858_ChIP-Seq_MCF-7_Human1.62212543
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61076302
52MYB_26560356_Chip-Seq_TH2_Human1.60699976
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57848403
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57716658
55TP53_22573176_ChIP-Seq_HFKS_Human1.57528764
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57347139
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56360797
58* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.54836143
59P300_19829295_ChIP-Seq_ESCs_Human1.54813843
60SCL_19346495_ChIP-Seq_HPC-7_Human1.54602759
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53426567
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52216521
63* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51017014
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50615953
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50283754
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.50250260
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46437692
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45089580
69RUNX_20019798_ChIP-Seq_JUKART_Human1.44000385
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42931613
71* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42184267
72MYB_26560356_Chip-Seq_TH1_Human1.41465601
73IRF8_27001747_Chip-Seq_BMDM_Mouse1.39556851
74* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38842176
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35067415
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34771786
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34344585
78* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34059796
79* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33572716
80* VDR_23849224_ChIP-Seq_CD4+_Human1.32983443
81* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32004900
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31869755
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31799462
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.30843582
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.29647530
86CIITA_25753668_ChIP-Seq_RAJI_Human1.28466454
87* GABP_19822575_ChIP-Seq_HepG2_Human1.26384129
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26197278
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25602449
90TTF2_22483619_ChIP-Seq_HELA_Human1.25238869
91SPI1_23547873_ChIP-Seq_NB4_Human1.25167582
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24449205
93* FOXP3_21729870_ChIP-Seq_TREG_Human1.23569029
94MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22856425
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21425601
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16910430
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14639042
98EST1_17652178_ChIP-ChIP_JURKAT_Human1.13795712
99* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13039301
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12949794
101* FOXA1_25329375_ChIP-Seq_VCAP_Human1.12827817
102* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12827817
103NCOR_22424771_ChIP-Seq_293T_Human1.12566099
104* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11911806
105SOX2_16153702_ChIP-ChIP_HESCs_Human1.11584129
106EWS_26573619_Chip-Seq_HEK293_Human1.10045453
107RNF2_27304074_Chip-Seq_NSC_Mouse1.09870012
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08609498
109KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08078140
110BCAT_22108803_ChIP-Seq_LS180_Human1.07752002
111* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06268700
112* GATA3_21878914_ChIP-Seq_MCF-7_Human1.04915804
113AR_20517297_ChIP-Seq_VCAP_Human1.03931953
114RUNX1_22412390_ChIP-Seq_EML_Mouse1.03670866
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02553249
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01950601
117VDR_21846776_ChIP-Seq_THP-1_Human1.01182967
118CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00803383
119DCP1A_22483619_ChIP-Seq_HELA_Human1.00632569
120MAF_26560356_Chip-Seq_TH1_Human1.00593800
121AR_25329375_ChIP-Seq_VCAP_Human0.99908625
122RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99903553
123HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99548729
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99512414
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99321463
126CBP_20019798_ChIP-Seq_JUKART_Human0.99321463
127* PU_27001747_Chip-Seq_BMDM_Mouse0.99157688
128ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97741724
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97439715
130REST_21632747_ChIP-Seq_MESCs_Mouse0.95059987
131* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94539335
132AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93953178
133NANOG_19829295_ChIP-Seq_ESCs_Human0.93222776
134SOX2_19829295_ChIP-Seq_ESCs_Human0.93222776
135* KDM5A_27292631_Chip-Seq_BREAST_Human0.92922442
136SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92789128
137SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92789128
138SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92681750
139SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91110977
140KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90575501
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89887466
142WT1_19549856_ChIP-ChIP_CCG9911_Human0.87215118
143ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87195226
144SMAD_19615063_ChIP-ChIP_OVARY_Human0.87133561
145ERG_20517297_ChIP-Seq_VCAP_Human0.87030725
146CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.86986319
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86952369
148UTX_26944678_Chip-Seq_JUKART_Human0.86491600
149* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86289981
150PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84915655
151CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84351968
152* GABP_17652178_ChIP-ChIP_JURKAT_Human0.84242644
153PCGF2_27294783_Chip-Seq_ESCs_Mouse0.83360185
154VDR_24763502_ChIP-Seq_THP-1_Human0.81932718
155POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.80570849
156TFEB_21752829_ChIP-Seq_HELA_Human0.78586918
157* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78272557
158TCF7_22412390_ChIP-Seq_EML_Mouse0.77683402
159XRN2_22483619_ChIP-Seq_HELA_Human0.77522666
160E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77498096
161PKCTHETA_26484144_Chip-Seq_BREAST_Human0.77328227
162GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76832716
163CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.76795016
164POU5F1_16153702_ChIP-ChIP_HESCs_Human0.76027267
165NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.75764435
166PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75764338
167GATA3_27048872_Chip-Seq_THYMUS_Human0.73111563
168PCGF2_27294783_Chip-Seq_NPCs_Mouse0.72710224
169MYC_18940864_ChIP-ChIP_HL60_Human0.71991658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.73816283
2MP0008057_abnormal_DNA_replication3.52069105
3MP0006292_abnormal_olfactory_placode3.18300469
4MP0010094_abnormal_chromosome_stability3.08787405
5MP0002396_abnormal_hematopoietic_system2.76452648
6MP0006072_abnormal_retinal_apoptosis2.58701778
7MP0002102_abnormal_ear_morphology2.57574388
8MP0003718_maternal_effect2.55517327
9MP0003111_abnormal_nucleus_morphology2.39181349
10MP0003077_abnormal_cell_cycle2.29684615
11MP0005646_abnormal_pituitary_gland2.24385145
12MP0004808_abnormal_hematopoietic_stem2.23700319
13MP0003763_abnormal_thymus_physiology2.17445840
14MP0003693_abnormal_embryo_hatching2.16709461
15MP0008058_abnormal_DNA_repair2.15186948
16MP0003011_delayed_dark_adaptation2.04229089
17MP0001835_abnormal_antigen_presentation2.00885388
18MP0002160_abnormal_reproductive_system1.90972535
19MP0001485_abnormal_pinna_reflex1.88292413
20MP0005551_abnormal_eye_electrophysiolog1.84524872
21MP0010352_gastrointestinal_tract_polyps1.83223203
22MP0000372_irregular_coat_pigmentation1.82495430
23MP0008789_abnormal_olfactory_epithelium1.81730401
24MP0002166_altered_tumor_susceptibility1.80045207
25MP0000631_abnormal_neuroendocrine_gland1.79441549
26MP0008875_abnormal_xenobiotic_pharmacok1.79091404
27MP0001800_abnormal_humoral_immune1.78947600
28MP0008007_abnormal_cellular_replicative1.76481483
29MP0005253_abnormal_eye_physiology1.75394379
30MP0008995_early_reproductive_senescence1.74101258
31MP0002009_preneoplasia1.73466104
32MP0000566_synostosis1.72291764
33MP0002398_abnormal_bone_marrow1.70419069
34MP0003315_abnormal_perineum_morphology1.69751459
35MP0004133_heterotaxia1.68456530
36MP0005671_abnormal_response_to1.66746150
37MP0000685_abnormal_immune_system1.65769540
38MP0005409_darkened_coat_color1.64844618
39MP0005645_abnormal_hypothalamus_physiol1.63698591
40MP0006276_abnormal_autonomic_nervous1.62527666
41MP0002006_tumorigenesis1.61830058
42MP0001968_abnormal_touch/_nociception1.61296196
43MP0002736_abnormal_nociception_after1.60897411
44MP0001529_abnormal_vocalization1.59098529
45MP0002938_white_spotting1.58203125
46MP0001790_abnormal_immune_system1.56683286
47MP0005387_immune_system_phenotype1.56683286
48MP0008877_abnormal_DNA_methylation1.56535415
49MP0004142_abnormal_muscle_tone1.56291403
50MP0008872_abnormal_physiological_respon1.53348968
51MP0002452_abnormal_antigen_presenting1.52980897
52MP0003787_abnormal_imprinting1.52467319
53MP0002751_abnormal_autonomic_nervous1.51407937
54MP0010307_abnormal_tumor_latency1.51024147
55MP0003786_premature_aging1.50795013
56MP0000703_abnormal_thymus_morphology1.50778387
57MP0004957_abnormal_blastocyst_morpholog1.50523008
58MP0005389_reproductive_system_phenotype1.50066773
59MP0002876_abnormal_thyroid_physiology1.45707246
60MP0006054_spinal_hemorrhage1.45159432
61MP0002420_abnormal_adaptive_immunity1.44001531
62MP0005084_abnormal_gallbladder_morpholo1.43169568
63MP0001873_stomach_inflammation1.42203356
64MP0001819_abnormal_immune_cell1.41844560
65MP0002234_abnormal_pharynx_morphology1.41501035
66MP0005075_abnormal_melanosome_morpholog1.41334459
67MP0000490_abnormal_crypts_of1.39828709
68MP0000689_abnormal_spleen_morphology1.39378520
69MP0002722_abnormal_immune_system1.37647730
70MP0002723_abnormal_immune_serum1.37595130
71MP0000716_abnormal_immune_system1.36146929
72MP0003880_abnormal_central_pattern1.34862636
73MP0004885_abnormal_endolymph1.33889648
74MP0009046_muscle_twitch1.33501488
75MP0001879_abnormal_lymphatic_vessel1.32901129
76MP0005076_abnormal_cell_differentiation1.32330948
77MP0000350_abnormal_cell_proliferation1.31367886
78MP0001293_anophthalmia1.28850878
79MP0002822_catalepsy1.28806099
80MP0002282_abnormal_trachea_morphology1.28210846
81MP0002405_respiratory_system_inflammati1.26787256
82MP0003984_embryonic_growth_retardation1.25682950
83MP0001672_abnormal_embryogenesis/_devel1.25000786
84MP0005380_embryogenesis_phenotype1.25000786
85MP0002088_abnormal_embryonic_growth/wei1.24059150
86MP0000383_abnormal_hair_follicle1.24036134
87MP0002429_abnormal_blood_cell1.23836465
88MP0003943_abnormal_hepatobiliary_system1.23746657
89MP0009333_abnormal_splenocyte_physiolog1.23133485
90MP0005394_taste/olfaction_phenotype1.22420216
91MP0005499_abnormal_olfactory_system1.22420216
92MP0003121_genomic_imprinting1.21037340
93MP0002163_abnormal_gland_morphology1.20775340
94MP0002638_abnormal_pupillary_reflex1.17803624
95MP0009384_cardiac_valve_regurgitation1.16656406
96MP0005000_abnormal_immune_tolerance1.16159967
97MP0000049_abnormal_middle_ear1.15066183
98MP0000015_abnormal_ear_pigmentation1.14860690
99MP0006035_abnormal_mitochondrial_morpho1.13916110
100MP0001764_abnormal_homeostasis1.12758996
101MP0002735_abnormal_chemical_nociception1.12583802
102MP0009785_altered_susceptibility_to1.12513503
103MP0005397_hematopoietic_system_phenotyp1.12007176
104MP0001545_abnormal_hematopoietic_system1.12007176
105MP0008932_abnormal_embryonic_tissue1.11925067
106MP0001853_heart_inflammation1.11758884
107MP0003941_abnormal_skin_development1.11429069
108MP0001188_hyperpigmentation1.10070851
109MP0004197_abnormal_fetal_growth/weight/1.08103562
110MP0003890_abnormal_embryonic-extraembry1.07089306
111MP0002086_abnormal_extraembryonic_tissu1.07002867
112MP0000465_gastrointestinal_hemorrhage1.06587174
113MP0004742_abnormal_vestibular_system1.06563172
114MP0002095_abnormal_skin_pigmentation1.05892967
115MP0004043_abnormal_pH_regulation1.05759491
116MP0005174_abnormal_tail_pigmentation1.03485185
117MP0001730_embryonic_growth_arrest1.03370256
118MP0002419_abnormal_innate_immunity1.03146568
119MP0010155_abnormal_intestine_physiology1.03067232
120MP0009278_abnormal_bone_marrow1.02627380
121MP0005670_abnormal_white_adipose1.02573937
122MP0005195_abnormal_posterior_eye1.01033396
123MP0001697_abnormal_embryo_size1.00709760
124MP0005025_abnormal_response_to1.00322654
125MP0001905_abnormal_dopamine_level0.99426336
126MP0001919_abnormal_reproductive_system0.98812785
127MP0001986_abnormal_taste_sensitivity0.98797570
128MP0009745_abnormal_behavioral_response0.98778064
129MP0002557_abnormal_social/conspecific_i0.96765442
130MP0002019_abnormal_tumor_incidence0.95146560
131MP0002272_abnormal_nervous_system0.93769995
132MP0009697_abnormal_copulation0.93160410
133MP0000778_abnormal_nervous_system0.92804244
134MP0000569_abnormal_digit_pigmentation0.92667426
135MP0000013_abnormal_adipose_tissue0.92250091
136MP0001915_intracranial_hemorrhage0.92167103
137MP0003567_abnormal_fetal_cardiomyocyte0.91725497
138MP0002148_abnormal_hypersensitivity_rea0.90168193
139MP0006036_abnormal_mitochondrial_physio0.90108935
140MP0003436_decreased_susceptibility_to0.89849861
141MP0002572_abnormal_emotion/affect_behav0.89373895
142MP0009053_abnormal_anal_canal0.89241509
143MP0003950_abnormal_plasma_membrane0.88811048
144MP0003300_gastrointestinal_ulcer0.88509430
145MP0003195_calcinosis0.88147332
146MP0004947_skin_inflammation0.86795758
147MP0000653_abnormal_sex_gland0.86365654
148MP0003448_altered_tumor_morphology0.86331856
149MP0002085_abnormal_embryonic_tissue0.85168794
150MP0005367_renal/urinary_system_phenotyp0.83543595
151MP0000516_abnormal_urinary_system0.83543595
152MP0000313_abnormal_cell_death0.83437254
153MP0001145_abnormal_male_reproductive0.82671976
154MP0000733_abnormal_muscle_development0.82240365
155MP0000026_abnormal_inner_ear0.81891445
156MP0002210_abnormal_sex_determination0.81422636
157MP0002925_abnormal_cardiovascular_devel0.81416636
158MP0002928_abnormal_bile_duct0.81012775
159MP0003136_yellow_coat_color0.79772954
160MP0000427_abnormal_hair_cycle0.79025014
161MP0004147_increased_porphyrin_level0.78796362
162MP0002752_abnormal_somatic_nervous0.78216280
163MP0002132_abnormal_respiratory_system0.78146018
164MP0001963_abnormal_hearing_physiology0.77356114
165MP0001984_abnormal_olfaction0.76713093
166MP0001929_abnormal_gametogenesis0.76278698
167MP0002084_abnormal_developmental_patter0.76259825
168MP0003119_abnormal_digestive_system0.76234677
169MP0004924_abnormal_behavior0.75912892
170MP0005386_behavior/neurological_phenoty0.75912892
171MP0010678_abnormal_skin_adnexa0.75899302
172MP0003698_abnormal_male_reproductive0.75723279
173MP0005391_vision/eye_phenotype0.75345547
174MP0003937_abnormal_limbs/digits/tail_de0.75289462
175MP0001119_abnormal_female_reproductive0.74558850
176MP0002837_dystrophic_cardiac_calcinosis0.74514695
177MP0000767_abnormal_smooth_muscle0.74058792
178MP0002080_prenatal_lethality0.73806087
179MP0002092_abnormal_eye_morphology0.73352631
180MP0009703_decreased_birth_body0.73242263
181MP0002067_abnormal_sensory_capabilities0.72496622
182MP0005379_endocrine/exocrine_gland_phen0.71599616
183MP0000613_abnormal_salivary_gland0.68414403
184MP0005408_hypopigmentation0.67486039

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.65026958
2Chromsome breakage (HP:0040012)3.49945384
3Pancreatic cysts (HP:0001737)3.49246487
4Abnormal mitochondria in muscle tissue (HP:0008316)3.47951069
5Mitochondrial inheritance (HP:0001427)3.45514950
6Hepatocellular necrosis (HP:0001404)3.36098000
7Congenital stationary night blindness (HP:0007642)3.33521359
8Pancreatic fibrosis (HP:0100732)3.23871541
9Acute encephalopathy (HP:0006846)3.23858829
10Molar tooth sign on MRI (HP:0002419)3.22816260
11Abnormality of midbrain morphology (HP:0002418)3.22816260
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19942093
13Ectopic kidney (HP:0000086)3.15646724
14Increased CSF lactate (HP:0002490)3.11030290
15Abnormality of the fingertips (HP:0001211)3.10638542
16Nephronophthisis (HP:0000090)3.08366449
17True hermaphroditism (HP:0010459)3.07439852
18Absent thumb (HP:0009777)3.06513591
19Hepatic necrosis (HP:0002605)2.98224131
20Pendular nystagmus (HP:0012043)2.97646960
21Progressive macrocephaly (HP:0004481)2.97627998
22Syringomyelia (HP:0003396)2.96387014
23Spinal cord lesions (HP:0100561)2.96387014
24Abnormality of T cell number (HP:0011839)2.91412898
25Acute myeloid leukemia (HP:0004808)2.86270322
26Stenosis of the external auditory canal (HP:0000402)2.80854352
27Type II lissencephaly (HP:0007260)2.79091581
28T lymphocytopenia (HP:0005403)2.78547468
29Abolished electroretinogram (ERG) (HP:0000550)2.73914364
30Recurrent viral infections (HP:0004429)2.69053392
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.55438084
32Short 4th metacarpal (HP:0010044)2.55438084
33Carpal bone hypoplasia (HP:0001498)2.55423560
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.52217759
35Cerebral edema (HP:0002181)2.51651588
36Lipid accumulation in hepatocytes (HP:0006561)2.48920423
37Abnormality of the renal medulla (HP:0100957)2.47070042
38Short 1st metacarpal (HP:0010034)2.45640461
39Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.45640461
40Medial flaring of the eyebrow (HP:0010747)2.44811601
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.43795501
42Long eyelashes (HP:0000527)2.41442220
43Tachypnea (HP:0002789)2.39397651
44Abnormality of chromosome stability (HP:0003220)2.39028295
45Autoimmune thrombocytopenia (HP:0001973)2.38256333
46Methylmalonic acidemia (HP:0002912)2.37236457
47Renal duplication (HP:0000075)2.28901665
48Methylmalonic aciduria (HP:0012120)2.28392796
49Eosinophilia (HP:0001880)2.26683329
50Reticulocytopenia (HP:0001896)2.25396198
51Deep philtrum (HP:0002002)2.23465989
52Increased nuchal translucency (HP:0010880)2.21810557
53B lymphocytopenia (HP:0010976)2.21246641
54Abnormality of B cell number (HP:0010975)2.21246641
553-Methylglutaconic aciduria (HP:0003535)2.20867791
56Lymphoma (HP:0002665)2.19104001
57Abnormal rod and cone electroretinograms (HP:0008323)2.18309117
58Abnormality of alanine metabolism (HP:0010916)2.18112570
59Hyperalaninemia (HP:0003348)2.18112570
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18112570
61Severe combined immunodeficiency (HP:0004430)2.17264273
62Thyroiditis (HP:0100646)2.16957069
63Bile duct proliferation (HP:0001408)2.15003502
64Abnormal biliary tract physiology (HP:0012439)2.15003502
65Abnormality of the 1st metacarpal (HP:0010009)2.12693726
66Hyperacusis (HP:0010780)2.11989445
67Sclerocornea (HP:0000647)2.11515226
68Optic disc pallor (HP:0000543)2.11323599
69Triphalangeal thumb (HP:0001199)2.11095369
70Abnormality of the carotid arteries (HP:0005344)2.10761619
71Recurrent fungal infections (HP:0002841)2.10171997
72Cystic liver disease (HP:0006706)2.10094880
73Abnormality of the renal cortex (HP:0011035)2.09775010
74Decreased central vision (HP:0007663)2.08965617
75Increased serum lactate (HP:0002151)2.08186233
76Retinal dysplasia (HP:0007973)2.08163764
77Abnormality of T cells (HP:0002843)2.07970624
78Lactic acidosis (HP:0003128)2.07494108
79Cerebellar dysplasia (HP:0007033)2.06089922
80Abnormality of the parathyroid morphology (HP:0011766)2.02876340
81Increased hepatocellular lipid droplets (HP:0006565)2.00956229
82Aplasia/Hypoplasia of the uvula (HP:0010293)2.00555205
83Hyperglycinuria (HP:0003108)2.00184819
84Abnormal number of erythroid precursors (HP:0012131)2.00133542
85Inability to walk (HP:0002540)2.00063302
86Meckel diverticulum (HP:0002245)1.99940347
87Renal cortical cysts (HP:0000803)1.99628523
88Volvulus (HP:0002580)1.99103334
89Myelodysplasia (HP:0002863)1.98839773
90Renovascular hypertension (HP:0100817)1.98207611
91Absent/shortened dynein arms (HP:0200106)1.97512081
92Dynein arm defect of respiratory motile cilia (HP:0012255)1.97512081
93Abnormality of cells of the lymphoid lineage (HP:0012140)1.97335273
94Keratoconus (HP:0000563)1.95248754
95Increased corneal curvature (HP:0100692)1.95248754
96Panhypogammaglobulinemia (HP:0003139)1.94495317
97IgM deficiency (HP:0002850)1.93668133
98Attenuation of retinal blood vessels (HP:0007843)1.93042768
99Cutaneous melanoma (HP:0012056)1.92306584
100Hyperglycinemia (HP:0002154)1.92299199
101Lymphopenia (HP:0001888)1.92100072
102Abnormality of eosinophils (HP:0001879)1.91869152
103Clubbing of toes (HP:0100760)1.91675394
104Gait imbalance (HP:0002141)1.91666561
105Aplasia/Hypoplasia involving the musculature (HP:0001460)1.91484306
106Lip pit (HP:0100267)1.91191822
107Combined immunodeficiency (HP:0005387)1.91174411
108Eczematoid dermatitis (HP:0000976)1.90504474
109Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90425033
110Abnormality of the columella (HP:0009929)1.90348045
111Absent radius (HP:0003974)1.89497556
112Chronic otitis media (HP:0000389)1.89222252
113Aplasia involving forearm bones (HP:0009822)1.89163386
114Absent forearm bone (HP:0003953)1.89163386
115Congenital primary aphakia (HP:0007707)1.89065147
116Elfin facies (HP:0004428)1.88866792
117Granulocytopenia (HP:0001913)1.88169351
118IgA deficiency (HP:0002720)1.87981637
119Abnormality of the renal collecting system (HP:0004742)1.87698410
120Aplasia/Hypoplasia of the tongue (HP:0010295)1.87576491
121Aplasia cutis congenita (HP:0001057)1.87085029
122Medulloblastoma (HP:0002885)1.84951993
123Lethargy (HP:0001254)1.84597697
124Lissencephaly (HP:0001339)1.84376096
125Ectropion (HP:0000656)1.83590422
126Abnormality of the ileum (HP:0001549)1.82743534
127Abnormality of the nasal septum (HP:0000419)1.81747506
128Asymmetry of the thorax (HP:0001555)1.81638894
129Abnormal lung lobation (HP:0002101)1.81291701
130Horseshoe kidney (HP:0000085)1.81175109
131Stomach cancer (HP:0012126)1.81034897
132IgG deficiency (HP:0004315)1.80026974
133Abnormal delayed hypersensitivity skin test (HP:0002963)1.79936312
134Abnormal protein glycosylation (HP:0012346)1.79829527
135Abnormal glycosylation (HP:0012345)1.79829527
136Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79829527
137Abnormal protein N-linked glycosylation (HP:0012347)1.79829527
138Nephrogenic diabetes insipidus (HP:0009806)1.79756104
139Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79587142
140Intestinal fistula (HP:0100819)1.79490859
141Deviation of the thumb (HP:0009603)1.78479002
142Abnormality of serine family amino acid metabolism (HP:0010894)1.77874788
143Abnormality of glycine metabolism (HP:0010895)1.77874788
144Aganglionic megacolon (HP:0002251)1.77869452
145Bicuspid aortic valve (HP:0001647)1.77176491
146Osteomyelitis (HP:0002754)1.77136653
147Chronic hepatic failure (HP:0100626)1.76922986
148Abnormality of the preputium (HP:0100587)1.76341964
149Abnormality of DNA repair (HP:0003254)1.76215136
150Mediastinal lymphadenopathy (HP:0100721)1.74894216
151Nephroblastoma (Wilms tumor) (HP:0002667)1.72445019
152Skull defect (HP:0001362)1.71768829
153Leukopenia (HP:0001882)1.71465126
154Selective tooth agenesis (HP:0001592)1.71340549
155Mesomelia (HP:0003027)1.70629513
156Cutis marmorata (HP:0000965)1.70547008
157Absent frontal sinuses (HP:0002688)1.70516327
158Retrobulbar optic neuritis (HP:0100654)1.70202887
159Optic neuritis (HP:0100653)1.70202887
160Small intestinal stenosis (HP:0012848)1.69208308
161Duodenal stenosis (HP:0100867)1.69208308
162Leukocytosis (HP:0001974)1.69180099
163Chronic diarrhea (HP:0002028)1.68749094
164Overriding aorta (HP:0002623)1.67077360
165Colon cancer (HP:0003003)1.66770376
166Duplicated collecting system (HP:0000081)1.66539336
167Birth length less than 3rd percentile (HP:0003561)1.65989207
168Embryonal renal neoplasm (HP:0011794)1.65181264
169Abnormality of the incisor (HP:0000676)1.64146157
170Bone marrow hypocellularity (HP:0005528)1.63499860
171Optic nerve coloboma (HP:0000588)1.62515509
172Blepharitis (HP:0000498)1.62467518
173Short middle phalanx of the 5th finger (HP:0004220)1.62342838
174Myositis (HP:0100614)1.61885159
175Thrombocytosis (HP:0001894)1.61851435
176Amaurosis fugax (HP:0100576)1.61172323
177Hematochezia (HP:0002573)1.60047384
178Proximal placement of thumb (HP:0009623)1.59025641
179Recurrent bronchitis (HP:0002837)1.58402797
180Abnormality of T cell physiology (HP:0011840)1.55437851
181Recurrent abscess formation (HP:0002722)1.54928823
182Sloping forehead (HP:0000340)1.54685455
183Anal stenosis (HP:0002025)1.54012739
184Vasculitis (HP:0002633)1.51915013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.36225072
2MAP4K23.35102541
3VRK22.93540794
4CDC72.59042575
5CDK122.54721275
6BCKDK2.53740729
7SRPK12.43158047
8BRD42.42156541
9MKNK12.39727095
10MKNK22.25977434
11BMPR1B2.22481459
12TXK2.20665139
13ADRBK22.18759699
14STK162.15824940
15MAP4K12.13849966
16LATS12.07474818
17MAP3K142.06690402
18STK102.02254538
19ZAK1.92984067
20JAK31.85030319
21PINK11.83813434
22NEK21.81683500
23STK31.77956967
24MAPK131.76468095
25MST41.75581750
26YES11.73838429
27WNK31.71702772
28IRAK31.63855221
29NUAK11.63671603
30PIM11.60729528
31DYRK21.57375245
32STK41.55720641
33EIF2AK11.50032399
34EIF2AK31.46703461
35ATR1.45872584
36INSRR1.45122418
37TEC1.41968808
38NLK1.40139448
39EIF2AK21.39727596
40MAP3K101.37044763
41IKBKB1.36292549
42NEK91.33240312
43CLK11.31754852
44CHUK1.30580206
45BTK1.30472997
46CDK41.30180654
47CCNB11.26659664
48TSSK61.26095406
49TYK21.25854700
50CDK71.24848194
51MELK1.24518481
52WNK41.23759440
53MAP2K71.23709107
54CASK1.23113195
55RPS6KA41.21321838
56CDK91.21048237
57TLK11.19974996
58PNCK1.18867685
59PLK41.18507464
60IRAK41.14897512
61FGFR31.14449632
62MAP3K41.13852147
63PRPF4B1.11332027
64CHEK21.10197515
65CSNK1G21.08919673
66VRK11.07720649
67TAF11.07373126
68CSNK1G31.06280762
69EPHA31.04929715
70CDK61.04522841
71BRSK21.03877581
72ITK1.02733456
73CSNK1G11.01176550
74TGFBR21.00234871
75RPS6KB20.99613293
76ZAP700.99322426
77CHEK10.98325565
78OXSR10.96621706
79KIT0.94383270
80CDK80.92579485
81ATM0.91779528
82WEE10.90720157
83CSNK1A1L0.90198316
84EEF2K0.89285429
85AURKB0.88410147
86TGFBR10.86576557
87TNIK0.85249669
88IKBKE0.83691431
89AURKA0.83545229
90TRPM70.83043315
91JAK10.82824421
92PASK0.82225465
93GRK10.81400708
94MAPKAPK50.80244838
95PTK60.78593831
96PLK20.76785293
97LCK0.76113977
98AKT30.75127522
99RPS6KA50.75125819
100PRKCG0.74340796
101MAP2K20.74190005
102PLK30.73617764
103CSF1R0.73234426
104NME10.69781349
105TTK0.69289172
106PLK10.68411370
107STK240.68392282
108MARK30.67659198
109CSNK1A10.67145232
110DYRK30.66818280
111TRIM280.65794061
112MARK10.65484026
113STK390.64355520
114PRKCE0.63803728
115CSK0.61831672
116HCK0.60657589
117ACVR1B0.60558837
118PIM20.60492469
119FRK0.56386837
120PDGFRB0.55561970
121TESK20.55496795
122FLT30.54809508
123CDK20.53816898
124MUSK0.53042866
125BUB10.52818423
126CSNK2A10.52321009
127PIK3CA0.52281765
128MAPK70.52248744
129ADRBK10.50759813
130LYN0.49914226
131MAP2K30.49638494
132MAP2K60.49361020
133CDK10.49172789
134RPS6KB10.48608687
135SYK0.48063608
136MAP3K80.48023303
137CSNK1D0.45227240
138MTOR0.44264629
139PAK30.44226810
140FGFR10.44047334
141STK38L0.43173149
142TAOK20.42245315
143TBK10.41891624
144MAPKAPK20.40330243
145PRKACA0.39821476
146NTRK20.39711935
147SGK20.39404806
148MAPKAPK30.38783548
149KDR0.38690185
150PHKG20.38516589
151PHKG10.38516589
152IGF1R0.38486388
153CDK30.37099915
154CAMK2A0.35163371
155CSNK2A20.35070903
156PRKCI0.33982137
157MINK10.33938611
158PRKCQ0.33473060
159TIE10.32529817
160DAPK20.31874573

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.76395924
2Oxidative phosphorylation_Homo sapiens_hsa001902.66982517
3Protein export_Homo sapiens_hsa030602.50440266
4Mismatch repair_Homo sapiens_hsa034302.49203687
5Homologous recombination_Homo sapiens_hsa034402.44586543
6Non-homologous end-joining_Homo sapiens_hsa034502.38243363
7Parkinsons disease_Homo sapiens_hsa050122.34024739
8Cell cycle_Homo sapiens_hsa041102.08705839
9Primary immunodeficiency_Homo sapiens_hsa053402.08002358
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.07656334
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05479419
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95567531
13Fanconi anemia pathway_Homo sapiens_hsa034601.95010691
14Base excision repair_Homo sapiens_hsa034101.92971768
15Phototransduction_Homo sapiens_hsa047441.85026471
16Selenocompound metabolism_Homo sapiens_hsa004501.84875291
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.84231465
18Herpes simplex infection_Homo sapiens_hsa051681.80744720
19Spliceosome_Homo sapiens_hsa030401.79671362
20Butanoate metabolism_Homo sapiens_hsa006501.79616801
21RNA transport_Homo sapiens_hsa030131.78443084
22Measles_Homo sapiens_hsa051621.76183881
23Proteasome_Homo sapiens_hsa030501.74633531
24Allograft rejection_Homo sapiens_hsa053301.71393190
25Nucleotide excision repair_Homo sapiens_hsa034201.70925048
26Huntingtons disease_Homo sapiens_hsa050161.66911018
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65865722
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.61756890
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60737069
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60235687
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57725004
32mRNA surveillance pathway_Homo sapiens_hsa030151.57694418
33RNA degradation_Homo sapiens_hsa030181.55923665
34One carbon pool by folate_Homo sapiens_hsa006701.54150505
35Sulfur metabolism_Homo sapiens_hsa009201.53009921
36p53 signaling pathway_Homo sapiens_hsa041151.51652012
37Alzheimers disease_Homo sapiens_hsa050101.51206005
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.49680098
39Tryptophan metabolism_Homo sapiens_hsa003801.49069126
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.49063323
41Systemic lupus erythematosus_Homo sapiens_hsa053221.47892903
42Linoleic acid metabolism_Homo sapiens_hsa005911.46506065
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46119473
44Hematopoietic cell lineage_Homo sapiens_hsa046401.41352085
45Autoimmune thyroid disease_Homo sapiens_hsa053201.38428803
46Small cell lung cancer_Homo sapiens_hsa052221.38253957
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37194988
48Basal transcription factors_Homo sapiens_hsa030221.36942546
49Peroxisome_Homo sapiens_hsa041461.36444019
50Antigen processing and presentation_Homo sapiens_hsa046121.36195757
51Propanoate metabolism_Homo sapiens_hsa006401.35819071
52Sulfur relay system_Homo sapiens_hsa041221.34666751
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33284588
54Nicotine addiction_Homo sapiens_hsa050331.30263000
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30121068
56Leishmaniasis_Homo sapiens_hsa051401.30114366
57MicroRNAs in cancer_Homo sapiens_hsa052061.29381556
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28889184
59Fatty acid elongation_Homo sapiens_hsa000621.28003959
60Caffeine metabolism_Homo sapiens_hsa002321.27877667
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27538373
62T cell receptor signaling pathway_Homo sapiens_hsa046601.26399273
63NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26338559
64B cell receptor signaling pathway_Homo sapiens_hsa046621.26164260
65Viral carcinogenesis_Homo sapiens_hsa052031.25169637
66Graft-versus-host disease_Homo sapiens_hsa053321.25064834
67HTLV-I infection_Homo sapiens_hsa051661.24383732
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22902659
69RNA polymerase_Homo sapiens_hsa030201.21642522
70Chemical carcinogenesis_Homo sapiens_hsa052041.19451881
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19162793
72Epstein-Barr virus infection_Homo sapiens_hsa051691.15544142
73Steroid hormone biosynthesis_Homo sapiens_hsa001401.12147887
74Ether lipid metabolism_Homo sapiens_hsa005651.10457358
75Chronic myeloid leukemia_Homo sapiens_hsa052201.10195301
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09817291
77Influenza A_Homo sapiens_hsa051641.09662487
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08764570
79Jak-STAT signaling pathway_Homo sapiens_hsa046301.08281723
80Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07697815
81Nitrogen metabolism_Homo sapiens_hsa009101.07558667
82Hepatitis B_Homo sapiens_hsa051611.07166769
83Legionellosis_Homo sapiens_hsa051341.06127402
84Cysteine and methionine metabolism_Homo sapiens_hsa002701.03740162
85Toxoplasmosis_Homo sapiens_hsa051451.01916848
86Osteoclast differentiation_Homo sapiens_hsa043800.99602789
87Pyrimidine metabolism_Homo sapiens_hsa002400.98741430
88Vitamin digestion and absorption_Homo sapiens_hsa049770.98724314
89Viral myocarditis_Homo sapiens_hsa054160.97202081
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96630746
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95969308
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.95812648
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95358834
94Retinol metabolism_Homo sapiens_hsa008300.95103808
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94656141
96Fatty acid metabolism_Homo sapiens_hsa012120.93889328
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93291094
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92720941
99Apoptosis_Homo sapiens_hsa042100.91980907
100Prostate cancer_Homo sapiens_hsa052150.89866281
101TNF signaling pathway_Homo sapiens_hsa046680.89196643
102Taste transduction_Homo sapiens_hsa047420.88556011
103Malaria_Homo sapiens_hsa051440.86508978
104Lysine degradation_Homo sapiens_hsa003100.85811997
105Acute myeloid leukemia_Homo sapiens_hsa052210.84847707
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84204961
107Cardiac muscle contraction_Homo sapiens_hsa042600.84011684
108* Metabolic pathways_Homo sapiens_hsa011000.83922298
109Renin-angiotensin system_Homo sapiens_hsa046140.82732598
110TGF-beta signaling pathway_Homo sapiens_hsa043500.82236373
111Asthma_Homo sapiens_hsa053100.81912625
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81717991
113beta-Alanine metabolism_Homo sapiens_hsa004100.79517328
114Basal cell carcinoma_Homo sapiens_hsa052170.79394221
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.79289027
116Adherens junction_Homo sapiens_hsa045200.77713099
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.76912883
118Pancreatic cancer_Homo sapiens_hsa052120.76433987
119Regulation of autophagy_Homo sapiens_hsa041400.76315844
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74781899
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73722336
122Notch signaling pathway_Homo sapiens_hsa043300.73250781
123Pathways in cancer_Homo sapiens_hsa052000.71009335
124Olfactory transduction_Homo sapiens_hsa047400.69451079
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69224396
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65330428
127Steroid biosynthesis_Homo sapiens_hsa001000.65171082
128Arachidonic acid metabolism_Homo sapiens_hsa005900.63356706
129Shigellosis_Homo sapiens_hsa051310.63290277
130Hepatitis C_Homo sapiens_hsa051600.62712220
131Colorectal cancer_Homo sapiens_hsa052100.62286275
132Chemokine signaling pathway_Homo sapiens_hsa040620.61737098
133Thyroid cancer_Homo sapiens_hsa052160.61514190
134Type I diabetes mellitus_Homo sapiens_hsa049400.61009214
135Proteoglycans in cancer_Homo sapiens_hsa052050.59838974
136FoxO signaling pathway_Homo sapiens_hsa040680.57811563
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57762322
138Collecting duct acid secretion_Homo sapiens_hsa049660.57651635
139Tyrosine metabolism_Homo sapiens_hsa003500.57368381
140Non-small cell lung cancer_Homo sapiens_hsa052230.55961995
141Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55086192
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54953053
143Purine metabolism_Homo sapiens_hsa002300.53761231
144Fatty acid degradation_Homo sapiens_hsa000710.53596123
145Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52760936
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52363745
147Hippo signaling pathway_Homo sapiens_hsa043900.52132122
148Endometrial cancer_Homo sapiens_hsa052130.51834039
149N-Glycan biosynthesis_Homo sapiens_hsa005100.50451706
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50168840
151Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50011807
152Glutathione metabolism_Homo sapiens_hsa004800.49683035
153* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49307142
154HIF-1 signaling pathway_Homo sapiens_hsa040660.48452768
155Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48345463
156Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47015938
157Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46222327
158Fat digestion and absorption_Homo sapiens_hsa049750.45257873
159Focal adhesion_Homo sapiens_hsa045100.43606099
160Tuberculosis_Homo sapiens_hsa051520.40497559
161Drug metabolism - other enzymes_Homo sapiens_hsa009830.40228384
162Prolactin signaling pathway_Homo sapiens_hsa049170.40088194
163Platelet activation_Homo sapiens_hsa046110.39137868
164Morphine addiction_Homo sapiens_hsa050320.39001153
165Ribosome_Homo sapiens_hsa030100.38600909
166Glycerolipid metabolism_Homo sapiens_hsa005610.37326597
167Pertussis_Homo sapiens_hsa051330.36792967
168Melanoma_Homo sapiens_hsa052180.36410243
169Histidine metabolism_Homo sapiens_hsa003400.35186697
170Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34267268
171Folate biosynthesis_Homo sapiens_hsa007900.32005453
172GABAergic synapse_Homo sapiens_hsa047270.30890207
173Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28452618

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