PIGN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is expressed in the endoplasmic reticulum and transfers phosphoethanolamine (EtNP) to the first mannose of the GPI anchor. Two alternatively spliced variants, which encode an identical isoform, have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal cone cell development (GO:0046549)4.68371913
2histone H3-K4 trimethylation (GO:0080182)4.61116528
3signal peptide processing (GO:0006465)4.59424200
4nuclear pore organization (GO:0006999)4.24796848
5branched-chain amino acid catabolic process (GO:0009083)4.24647917
6G-protein coupled receptor internalization (GO:0002031)4.13395389
7nuclear pore complex assembly (GO:0051292)4.05732583
8regulation of non-canonical Wnt signaling pathway (GO:2000050)3.90409710
9negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.75131118
10negative regulation of translation, ncRNA-mediated (GO:0040033)3.75131118
11regulation of translation, ncRNA-mediated (GO:0045974)3.75131118
12COPII vesicle coating (GO:0048208)3.74881331
13resolution of meiotic recombination intermediates (GO:0000712)3.71703642
14G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.70993250
15ionotropic glutamate receptor signaling pathway (GO:0035235)3.63056973
16glutamate receptor signaling pathway (GO:0007215)3.58517458
17protein prenylation (GO:0018342)3.52135509
18prenylation (GO:0097354)3.52135509
19detection of light stimulus involved in visual perception (GO:0050908)3.51547143
20detection of light stimulus involved in sensory perception (GO:0050962)3.51547143
21double-strand break repair via nonhomologous end joining (GO:0006303)3.50835781
22non-recombinational repair (GO:0000726)3.50835781
23ribosome assembly (GO:0042255)3.45240257
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44550157
25negative regulation of DNA-dependent DNA replication (GO:2000104)3.40334257
26regulation of DNA endoreduplication (GO:0032875)3.40324242
27peptidyl-lysine trimethylation (GO:0018023)3.31754091
28histone H3-K4 methylation (GO:0051568)3.29956291
29photoreceptor cell maintenance (GO:0045494)3.29796808
30Golgi to endosome transport (GO:0006895)3.28900130
31regulation of rhodopsin mediated signaling pathway (GO:0022400)3.26263217
32startle response (GO:0001964)3.21108536
33UDP-N-acetylglucosamine metabolic process (GO:0006047)3.20188554
34rhodopsin mediated signaling pathway (GO:0016056)3.18237721
35dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.18107162
36eye photoreceptor cell development (GO:0042462)3.17701358
37branched-chain amino acid metabolic process (GO:0009081)3.17050104
38rRNA methylation (GO:0031167)3.16187266
39superoxide anion generation (GO:0042554)3.14468410
40ketone body metabolic process (GO:1902224)3.13781262
41retina layer formation (GO:0010842)3.10952150
42respiratory chain complex IV assembly (GO:0008535)3.10317757
43desmosome organization (GO:0002934)3.09932255
44protein K6-linked ubiquitination (GO:0085020)3.09357595
45intracellular lipid transport (GO:0032365)3.09061722
46regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.03298603
47cellular ketone body metabolic process (GO:0046950)3.02916171
48L-alpha-amino acid transmembrane transport (GO:1902475)3.02788050
49DNA integration (GO:0015074)3.02566357
50zinc ion transport (GO:0006829)3.02008701
51mitochondrial DNA replication (GO:0006264)2.98690576
52DNA double-strand break processing (GO:0000729)2.98030152
53protein-chromophore linkage (GO:0018298)2.94608023
54synaptic transmission, glutamatergic (GO:0035249)2.93319650
55regulation of acyl-CoA biosynthetic process (GO:0050812)2.93035188
56metaphase plate congression (GO:0051310)2.91181674
57righting reflex (GO:0060013)2.91145251
58presynaptic membrane assembly (GO:0097105)2.90743091
59mitotic sister chromatid cohesion (GO:0007064)2.89777324
60photoreceptor cell development (GO:0042461)2.89640465
61establishment of chromosome localization (GO:0051303)2.88739275
62cilium or flagellum-dependent cell motility (GO:0001539)2.88197907
63water-soluble vitamin biosynthetic process (GO:0042364)2.85593828
64intestinal epithelial cell development (GO:0060576)2.83858970
65RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.82059960
66nucleotide transmembrane transport (GO:1901679)2.81753335
67L-amino acid import (GO:0043092)2.80809438
68female gonad development (GO:0008585)2.80627417
69microtubule depolymerization (GO:0007019)2.77152309
70kinetochore assembly (GO:0051382)2.77130131
71histone H3-K9 methylation (GO:0051567)2.76667989
72pore complex assembly (GO:0046931)2.75903461
73auditory receptor cell stereocilium organization (GO:0060088)2.75636664
74response to redox state (GO:0051775)2.74808074
75regulation of coenzyme metabolic process (GO:0051196)2.74353915
76regulation of cofactor metabolic process (GO:0051193)2.74353915
77cerebellar Purkinje cell differentiation (GO:0021702)2.74235337
78CENP-A containing nucleosome assembly (GO:0034080)2.73510637
79histone H3-K36 demethylation (GO:0070544)2.71267438
80inner ear receptor stereocilium organization (GO:0060122)2.71218034
81regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.70825455
82early endosome to late endosome transport (GO:0045022)2.70596636
83calcium ion import (GO:0070509)2.70299788
84regulation of sulfur metabolic process (GO:0042762)2.69949083
85zinc ion transmembrane transport (GO:0071577)2.69327141
86regulation of centriole replication (GO:0046599)2.67735485
87rRNA modification (GO:0000154)2.67310095
88DNA-dependent DNA replication (GO:0006261)2.67116559
89DNA ligation (GO:0006266)2.65638915
90sphingosine metabolic process (GO:0006670)2.64438642
91positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.63944114
92positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.63944114
93positive regulation of mitotic sister chromatid separation (GO:1901970)2.63944114
94regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.63489190
95DNA methylation involved in gamete generation (GO:0043046)2.61775551
96positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.61682030
97motile cilium assembly (GO:0044458)2.61468726
98histone mRNA metabolic process (GO:0008334)2.60766017
99auditory receptor cell differentiation (GO:0042491)2.60353065
100magnesium ion transport (GO:0015693)2.60154759
101negative regulation of keratinocyte proliferation (GO:0010839)2.56843252
102short-chain fatty acid metabolic process (GO:0046459)2.55745720
103spindle checkpoint (GO:0031577)2.55323048
104biotin metabolic process (GO:0006768)2.53112590
105nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.52945433
106synapsis (GO:0007129)2.52162631
107regulation of timing of cell differentiation (GO:0048505)2.51870893
108replicative senescence (GO:0090399)2.51727434
109genitalia morphogenesis (GO:0035112)2.51369856
110positive regulation of muscle hypertrophy (GO:0014742)2.51214397
111positive regulation of cardiac muscle hypertrophy (GO:0010613)2.51214397
112cell morphogenesis involved in neuron differentiation (GO:0048667)2.50515748
113regulation of synapse maturation (GO:0090128)2.50396950
114peroxisome fission (GO:0016559)2.50042915
115atrial cardiac muscle cell action potential (GO:0086014)2.49881161
116regulation of pigment cell differentiation (GO:0050932)2.49606233
117sphingoid metabolic process (GO:0046519)2.49512464
118mitotic metaphase plate congression (GO:0007080)2.49488436
119import into cell (GO:0098657)2.49434520
120protein localization to endosome (GO:0036010)2.48969911
121DNA catabolic process, exonucleolytic (GO:0000738)2.48316908
122spinal cord motor neuron differentiation (GO:0021522)2.48059315
123tRNA aminoacylation for protein translation (GO:0006418)2.48053756
124chromatin remodeling at centromere (GO:0031055)2.47348577
125bundle of His cell to Purkinje myocyte communication (GO:0086069)2.46800153
126mannosylation (GO:0097502)2.46291170
127kinetochore organization (GO:0051383)2.45517619
128DNA strand renaturation (GO:0000733)2.45490146
129serotonin receptor signaling pathway (GO:0007210)2.45380442
130histone lysine methylation (GO:0034968)2.45371626
131mitotic spindle checkpoint (GO:0071174)2.45300376
132presynaptic membrane organization (GO:0097090)2.45217573
133replication fork processing (GO:0031297)2.45003087
134neuron-neuron synaptic transmission (GO:0007270)2.44963348
135response to X-ray (GO:0010165)2.44927714
136epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.44900974
137limb bud formation (GO:0060174)2.44143720
138reflex (GO:0060004)2.43954877
139head development (GO:0060322)2.42863556
140positive regulation of glycoprotein biosynthetic process (GO:0010560)2.42729346
141protein localization to kinetochore (GO:0034501)2.42703781
142lactate metabolic process (GO:0006089)2.42447710
143tRNA aminoacylation (GO:0043039)2.42421224
144amino acid activation (GO:0043038)2.42421224
145regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.42103376
146regulation of mitotic metaphase/anaphase transition (GO:0030071)2.42103376
147negative regulation of JUN kinase activity (GO:0043508)2.41480019
148central nervous system projection neuron axonogenesis (GO:0021952)2.41458260
149positive regulation of protein autophosphorylation (GO:0031954)2.41200276
150cellular response to ATP (GO:0071318)2.40995429
151regulation of keratinocyte proliferation (GO:0010837)2.40911476
152interkinetic nuclear migration (GO:0022027)2.40184446
153sequestering of extracellular ligand from receptor (GO:0035581)2.39952620
154somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.39674515
155isotype switching (GO:0045190)2.39674515
156somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.39674515
157diol metabolic process (GO:0034311)2.39652375
158ER to Golgi vesicle-mediated transport (GO:0006888)2.39326232
159male sex determination (GO:0030238)2.39066281
160cellular response to vitamin D (GO:0071305)2.38634584
161meiotic chromosome segregation (GO:0045132)2.38307426
162neuron cell-cell adhesion (GO:0007158)2.37894121
163cranial nerve structural organization (GO:0021604)2.37248938
164iron ion import (GO:0097286)2.36899257
165nucleotide-sugar biosynthetic process (GO:0009226)2.36870989
166ER overload response (GO:0006983)2.36769074
167regulation of development, heterochronic (GO:0040034)2.36266362
168negative regulation of DNA recombination (GO:0045910)2.36129544
169sterol biosynthetic process (GO:0016126)2.35589113
170cell proliferation in forebrain (GO:0021846)2.35467843
171detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.34184366
172reciprocal meiotic recombination (GO:0007131)2.34164004
173reciprocal DNA recombination (GO:0035825)2.34164004
174oligosaccharide catabolic process (GO:0009313)2.33950652
175mesenchymal-epithelial cell signaling (GO:0060638)2.33757523
176ether lipid metabolic process (GO:0046485)2.33489321
177attachment of spindle microtubules to kinetochore (GO:0008608)2.33022710
178urinary tract smooth muscle contraction (GO:0014848)2.32077599
179regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.31161369
180negative regulation of synaptic transmission, GABAergic (GO:0032229)2.30541478
181histone H3-K9 modification (GO:0061647)2.29731171
182cAMP-mediated signaling (GO:0019933)2.28834603
183transmission of nerve impulse (GO:0019226)2.28723956
184behavioral response to ethanol (GO:0048149)2.28565736
185phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.27159854
186membrane hyperpolarization (GO:0060081)2.26793775
187positive regulation of cardiac muscle cell differentiation (GO:2000727)2.25275048
188gamma-aminobutyric acid signaling pathway (GO:0007214)2.25049078
189positive regulation of CREB transcription factor activity (GO:0032793)2.24933111
190regulation of gene expression by genetic imprinting (GO:0006349)2.24503761
191positive regulation of protein dephosphorylation (GO:0035307)2.23969562
192regulation of postsynaptic membrane potential (GO:0060078)2.22896463
193membrane depolarization during action potential (GO:0086010)2.22351311
194regulation of short-term neuronal synaptic plasticity (GO:0048172)2.22061481
195regulation of smoothened signaling pathway (GO:0008589)2.20631365
196microtubule anchoring (GO:0034453)2.19449189
197lateral sprouting from an epithelium (GO:0060601)2.18482355
198cilium assembly (GO:0042384)2.17610275

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.60995376
2EZH2_22144423_ChIP-Seq_EOC_Human3.80195059
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.20348381
4E2F7_22180533_ChIP-Seq_HELA_Human3.18945341
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.91636680
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60115443
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58718204
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.54379505
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.49479371
10ELK1_19687146_ChIP-ChIP_HELA_Human2.43361020
11* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.36078183
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.28506517
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24839469
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.15006338
15* SUZ12_27294783_Chip-Seq_NPCs_Mouse2.12735610
16* PCGF2_27294783_Chip-Seq_NPCs_Mouse2.10951981
17* NFE2_27457419_Chip-Seq_LIVER_Mouse2.02985964
18FUS_26573619_Chip-Seq_HEK293_Human2.02643551
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00783381
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00592173
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.95230754
22AR_21909140_ChIP-Seq_LNCAP_Human1.94002104
23PADI4_21655091_ChIP-ChIP_MCF-7_Human1.91879358
24* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.91452974
25DROSHA_22980978_ChIP-Seq_HELA_Human1.87160782
26* NANOG_18555785_Chip-Seq_ESCs_Mouse1.85191204
27SMAD4_21799915_ChIP-Seq_A2780_Human1.83073123
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.82770592
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.82505625
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82341970
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82217034
32ZNF274_21170338_ChIP-Seq_K562_Hela1.81514194
33* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.81430889
34P300_19829295_ChIP-Seq_ESCs_Human1.81099590
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78778352
36IGF1R_20145208_ChIP-Seq_DFB_Human1.78534560
37* E2F1_18555785_Chip-Seq_ESCs_Mouse1.78185454
38* EZH2_27294783_Chip-Seq_NPCs_Mouse1.75850045
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75203073
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72730016
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.72039945
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71946977
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71936075
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71455051
45* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69613497
46GATA1_22025678_ChIP-Seq_K562_Human1.68075591
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67191934
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.67191934
49* STAT3_23295773_ChIP-Seq_U87_Human1.67048173
50* P53_22387025_ChIP-Seq_ESCs_Mouse1.65022234
51TP53_16413492_ChIP-PET_HCT116_Human1.64273230
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62502361
53* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.62013575
54TAF15_26573619_Chip-Seq_HEK293_Human1.59977684
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.59951247
56* CBX2_27304074_Chip-Seq_ESCs_Mouse1.57566000
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57198844
58* CMYC_18555785_Chip-Seq_ESCs_Mouse1.56881018
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.56848888
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56273438
61TCF4_23295773_ChIP-Seq_U87_Human1.55541245
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55428990
63SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54044611
64* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.53900259
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53333471
66EWS_26573619_Chip-Seq_HEK293_Human1.52765959
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.51820094
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50396492
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49737343
70* STAT3_18555785_Chip-Seq_ESCs_Mouse1.49348467
71* P300_18555785_Chip-Seq_ESCs_Mouse1.49302253
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.48687371
73* OCT4_18555785_Chip-Seq_ESCs_Mouse1.48174229
74* NMYC_18555785_Chip-Seq_ESCs_Mouse1.48141961
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.45838834
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44213152
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44073735
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43559793
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.42754700
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40488421
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39791947
82AR_21572438_ChIP-Seq_LNCaP_Human1.39646969
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38481154
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38481154
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38283356
86* SOX2_18555785_Chip-Seq_ESCs_Mouse1.38277640
87* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.35795470
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35490929
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35269195
90* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34137835
91* KLF4_18555785_Chip-Seq_ESCs_Mouse1.33160253
92* ZFX_18555785_Chip-Seq_ESCs_Mouse1.33129190
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32901269
94* PU1_27457419_Chip-Seq_LIVER_Mouse1.30782656
95TP53_18474530_ChIP-ChIP_U2OS_Human1.30118339
96* BRD4_25478319_ChIP-Seq_HGPS_Human1.30103369
97CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29654091
98VDR_23849224_ChIP-Seq_CD4+_Human1.29596764
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29427942
100* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.29372612
101TAL1_26923725_Chip-Seq_HPCs_Mouse1.28270707
102* CDX2_22108803_ChIP-Seq_LS180_Human1.28007826
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.27381710
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26945374
105RNF2_27304074_Chip-Seq_ESCs_Mouse1.26420499
106ER_23166858_ChIP-Seq_MCF-7_Human1.25986806
107* CTCF_18555785_Chip-Seq_ESCs_Mouse1.25602857
108JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24943130
109RUNX2_22187159_ChIP-Seq_PCA_Human1.24771401
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24528610
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24046832
112EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23711776
113RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23711776
114AHR_22903824_ChIP-Seq_MCF-7_Human1.23369893
115ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23182258
116EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23127820
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23093197
118* CRX_20693478_ChIP-Seq_RETINA_Mouse1.21729379
119* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.21588935
120SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21185963
121REST_21632747_ChIP-Seq_MESCs_Mouse1.20656223
122ARNT_22903824_ChIP-Seq_MCF-7_Human1.20468243
123VDR_22108803_ChIP-Seq_LS180_Human1.20245361
124RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19870177
125FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19654159
126SALL4_22934838_ChIP-ChIP_CD34+_Human1.19293859
127RNF2_27304074_Chip-Seq_NSC_Mouse1.18642959
128HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18519444
129SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18391726
130MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18369944
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17864409
132* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.17746635
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17507567
134AR_25329375_ChIP-Seq_VCAP_Human1.17438405
135CBP_20019798_ChIP-Seq_JUKART_Human1.14753361
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14753361
137FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14317242
138MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13880459
139TBL1_22424771_ChIP-Seq_293T_Human1.13605239
140HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13585125
141KDM2B_26808549_Chip-Seq_REH_Human1.13062679
142YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09174992
143SRF_21415370_ChIP-Seq_HL-1_Mouse1.07016936
144* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06104473
145CJUN_26792858_Chip-Seq_BT549_Human1.01426862
146TCF4_22108803_ChIP-Seq_LS180_Human1.00169131
147FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98577397
148CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97975835
149Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97498508
150FOXP3_21729870_ChIP-Seq_TREG_Human0.97045174
151SOX17_20123909_ChIP-Seq_XEN_Mouse0.96632734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.60932085
2MP0006054_spinal_hemorrhage3.99328461
3MP0000569_abnormal_digit_pigmentation3.37552359
4MP0003787_abnormal_imprinting3.11620193
5MP0005551_abnormal_eye_electrophysiolog3.09663012
6MP0005409_darkened_coat_color2.92216623
7MP0000372_irregular_coat_pigmentation2.91373528
8MP0006292_abnormal_olfactory_placode2.88290028
9MP0003136_yellow_coat_color2.82763033
10MP0005408_hypopigmentation2.77695844
11MP0000566_synostosis2.58705447
12MP0010352_gastrointestinal_tract_polyps2.49349760
13MP0002102_abnormal_ear_morphology2.42026294
14MP0010234_abnormal_vibrissa_follicle2.40650821
15MP0001486_abnormal_startle_reflex2.32485239
16MP0006072_abnormal_retinal_apoptosis2.23645381
17MP0004272_abnormal_basement_membrane2.17500840
18MP0008877_abnormal_DNA_methylation2.07703934
19MP0003941_abnormal_skin_development2.06993343
20MP0005253_abnormal_eye_physiology2.06788314
21MP0004957_abnormal_blastocyst_morpholog2.05546814
22MP0009046_muscle_twitch1.97266334
23MP0003880_abnormal_central_pattern1.96989488
24MP0009697_abnormal_copulation1.95102404
25MP0005275_abnormal_skin_tensile1.87474679
26MP0003950_abnormal_plasma_membrane1.85102693
27MP0002735_abnormal_chemical_nociception1.84361954
28MP0003045_fibrosis1.82737567
29MP0008058_abnormal_DNA_repair1.77774287
30MP0004859_abnormal_synaptic_plasticity1.77310222
31MP0000383_abnormal_hair_follicle1.76432702
32MP0002837_dystrophic_cardiac_calcinosis1.74719254
33MP0008438_abnormal_cutaneous_collagen1.64647406
34MP0002254_reproductive_system_inflammat1.63777013
35MP0004147_increased_porphyrin_level1.63703814
36MP0004084_abnormal_cardiac_muscle1.63697401
37MP0000579_abnormal_nail_morphology1.63490836
38MP0005171_absent_coat_pigmentation1.62917396
39MP0004381_abnormal_hair_follicle1.61861001
40MP0005379_endocrine/exocrine_gland_phen1.60697650
41MP0004742_abnormal_vestibular_system1.58980812
42MP0003718_maternal_effect1.57111247
43MP0005423_abnormal_somatic_nervous1.53425320
44MP0000462_abnormal_digestive_system1.53214739
45MP0003195_calcinosis1.52981415
46MP0008007_abnormal_cellular_replicative1.51926293
47MP0009780_abnormal_chondrocyte_physiolo1.51539426
48MP0001968_abnormal_touch/_nociception1.51137472
49MP0009745_abnormal_behavioral_response1.47723464
50MP0004133_heterotaxia1.47371077
51MP0010307_abnormal_tumor_latency1.42471837
52MP0002166_altered_tumor_susceptibility1.41222713
53MP0003077_abnormal_cell_cycle1.39057406
54MP0002572_abnormal_emotion/affect_behav1.38064440
55MP0000371_diluted_coat_color1.37270411
56MP0005645_abnormal_hypothalamus_physiol1.36228863
57MP0003121_genomic_imprinting1.35574037
58MP0001440_abnormal_grooming_behavior1.34637254
59MP0001502_abnormal_circadian_rhythm1.31269362
60MP0002067_abnormal_sensory_capabilities1.31076177
61MP0002060_abnormal_skin_morphology1.29328648
62MP0008057_abnormal_DNA_replication1.29223862
63MP0002736_abnormal_nociception_after1.29146476
64MP0004142_abnormal_muscle_tone1.28684726
65MP0000026_abnormal_inner_ear1.28330237
66MP0008932_abnormal_embryonic_tissue1.27723703
67MP0002752_abnormal_somatic_nervous1.25636871
68MP0000427_abnormal_hair_cycle1.25239502
69MP0003635_abnormal_synaptic_transmissio1.24225388
70MP0003283_abnormal_digestive_organ1.24132436
71MP0002938_white_spotting1.23122228
72MP0000778_abnormal_nervous_system1.22510831
73MP0005075_abnormal_melanosome_morpholog1.22326492
74MP0005257_abnormal_intraocular_pressure1.22319864
75MP0003011_delayed_dark_adaptation1.21870720
76MP0005174_abnormal_tail_pigmentation1.21671706
77MP0002272_abnormal_nervous_system1.19558806
78MP0001986_abnormal_taste_sensitivity1.18713175
79MP0005195_abnormal_posterior_eye1.17283678
80MP0004145_abnormal_muscle_electrophysio1.17252390
81MP0003938_abnormal_ear_development1.16538617
82MP0001216_abnormal_epidermal_layer1.16068233
83MP0001963_abnormal_hearing_physiology1.15872014
84MP0005391_vision/eye_phenotype1.15271202
85MP0001661_extended_life_span1.15097858
86MP0008995_early_reproductive_senescence1.15074154
87MP0002277_abnormal_respiratory_mucosa1.13830010
88MP0002090_abnormal_vision1.13685410
89MP0002009_preneoplasia1.13112777
90MP0002006_tumorigenesis1.13046738
91MP0005085_abnormal_gallbladder_physiolo1.12479119
92MP0003868_abnormal_feces_composition1.12471770
93MP0001501_abnormal_sleep_pattern1.11929311
94MP0003186_abnormal_redox_activity1.11825004
95MP0005332_abnormal_amino_acid1.10835741
96MP0002638_abnormal_pupillary_reflex1.09254757
97MP0000015_abnormal_ear_pigmentation1.09219363
98MP0002734_abnormal_mechanical_nocicepti1.07916066
99MP0002557_abnormal_social/conspecific_i1.06659460
100MP0003111_abnormal_nucleus_morphology1.06514496
101MP0010678_abnormal_skin_adnexa1.06474619
102MP0001666_abnormal_nutrient_absorption1.05464786
103MP0004270_analgesia1.05425704
104MP0001764_abnormal_homeostasis1.04812246
105MP0000358_abnormal_cell_content/1.03550985
106MP0003937_abnormal_limbs/digits/tail_de1.02220120
107MP0002184_abnormal_innervation1.00493117
108MP0001485_abnormal_pinna_reflex0.99545483
109MP0001915_intracranial_hemorrhage0.97184809
110MP0002249_abnormal_larynx_morphology0.97052520
111MP0003806_abnormal_nucleotide_metabolis0.96169104
112MP0000647_abnormal_sebaceous_gland0.96075685
113MP0010094_abnormal_chromosome_stability0.94832310
114MP0005395_other_phenotype0.94408729
115MP0010386_abnormal_urinary_bladder0.94279215
116MP0001346_abnormal_lacrimal_gland0.94174381
117MP0002063_abnormal_learning/memory/cond0.93679266
118MP0002882_abnormal_neuron_morphology0.92769555
119MP0002396_abnormal_hematopoietic_system0.92738687
120MP0001299_abnormal_eye_distance/0.92047753
121MP0005248_abnormal_Harderian_gland0.91852829
122MP0005646_abnormal_pituitary_gland0.91713354
123MP0005220_abnormal_exocrine_pancreas0.91384966
124MP0003252_abnormal_bile_duct0.91328869
125MP0002108_abnormal_muscle_morphology0.91183662
126MP0002064_seizures0.91132446
127MP0000432_abnormal_head_morphology0.90452020
128MP0003566_abnormal_cell_adhesion0.89346111
129MP0001756_abnormal_urination0.88751740
130MP0000377_abnormal_hair_follicle0.87729298
131MP0008004_abnormal_stomach_pH0.87326727
132MP0004215_abnormal_myocardial_fiber0.87074838
133MP0002796_impaired_skin_barrier0.86355340
134MP0001293_anophthalmia0.85853398
135MP0001324_abnormal_eye_pigmentation0.85344010
136MP0002234_abnormal_pharynx_morphology0.84352741
137MP0006276_abnormal_autonomic_nervous0.83583530
138MP0002928_abnormal_bile_duct0.83077287
139MP0008775_abnormal_heart_ventricle0.83045484
140MP0002229_neurodegeneration0.82776852
141MP0003698_abnormal_male_reproductive0.82450377
142MP0003656_abnormal_erythrocyte_physiolo0.82275935
143MP0005636_abnormal_mineral_homeostasis0.81578672
144MP0001191_abnormal_skin_condition0.80862242
145MP0002177_abnormal_outer_ear0.78589149
146MP0005670_abnormal_white_adipose0.78556459
147MP0003786_premature_aging0.78437494
148MP0002088_abnormal_embryonic_growth/wei0.78389086
149MP0000631_abnormal_neuroendocrine_gland0.77812361
150MP0003984_embryonic_growth_retardation0.77495761
151MP0002075_abnormal_coat/hair_pigmentati0.75977412
152MP0002084_abnormal_developmental_patter0.75194093
153MP0002163_abnormal_gland_morphology0.75144082
154MP0006036_abnormal_mitochondrial_physio0.74442490
155MP0004264_abnormal_extraembryonic_tissu0.74271105
156MP0001186_pigmentation_phenotype0.74162279
157MP0002876_abnormal_thyroid_physiology0.74107547
158MP0001697_abnormal_embryo_size0.74030929
159MP0005330_cardiomyopathy0.73962502
160MP0004484_altered_response_of0.73253055
161MP0002086_abnormal_extraembryonic_tissu0.73136862
162MP0003878_abnormal_ear_physiology0.73025123
163MP0005377_hearing/vestibular/ear_phenot0.73025123
164MP0000049_abnormal_middle_ear0.72796016
165MP0003890_abnormal_embryonic-extraembry0.72732974
166MP0003755_abnormal_palate_morphology0.72406221
167MP0003935_abnormal_craniofacial_develop0.71740506
168MP0001672_abnormal_embryogenesis/_devel0.71310893
169MP0005380_embryogenesis_phenotype0.71310893
170MP0002233_abnormal_nose_morphology0.71017567
171MP0004036_abnormal_muscle_relaxation0.70548153
172MP0002095_abnormal_skin_pigmentation0.70376305
173MP0002896_abnormal_bone_mineralization0.69965195
174MP0001853_heart_inflammation0.68592454

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.91862611
2Chromsome breakage (HP:0040012)4.60349844
3Congenital stationary night blindness (HP:0007642)4.31505395
4Dyschromatopsia (HP:0007641)3.95067910
5Febrile seizures (HP:0002373)3.80066798
6Duplicated collecting system (HP:0000081)3.29260611
7Type I transferrin isoform profile (HP:0003642)3.04876232
8Abnormality of the renal collecting system (HP:0004742)3.01790047
9Upper limb muscle weakness (HP:0003484)2.88874876
10Hyperinsulinemic hypoglycemia (HP:0000825)2.88360081
11Focal motor seizures (HP:0011153)2.87805173
12Oligodactyly (hands) (HP:0001180)2.80561331
13Decreased central vision (HP:0007663)2.78628411
14Tubulointerstitial nephritis (HP:0001970)2.75845075
15Mesomelia (HP:0003027)2.75527522
16Methylmalonic acidemia (HP:0002912)2.72433147
17Abnormality of methionine metabolism (HP:0010901)2.69544734
18Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.65539995
19Abnormal protein N-linked glycosylation (HP:0012347)2.65539995
20Abnormal protein glycosylation (HP:0012346)2.65539995
21Abnormal glycosylation (HP:0012345)2.65539995
22Reduced antithrombin III activity (HP:0001976)2.64048268
23Bifid tongue (HP:0010297)2.58737495
24Septo-optic dysplasia (HP:0100842)2.58262955
25Vacuolated lymphocytes (HP:0001922)2.57653575
26Abnormality of the nasal septum (HP:0000419)2.56754301
27Hypoglycemic coma (HP:0001325)2.55399976
28Aplasia cutis congenita (HP:0001057)2.54895265
29Pancreatic islet-cell hyperplasia (HP:0004510)2.51273214
30Abnormality of the intrinsic pathway (HP:0010989)2.50095907
31Abnormality of vitamin B metabolism (HP:0004340)2.49292032
32Chronic hepatic failure (HP:0100626)2.49150781
33Abnormal ciliary motility (HP:0012262)2.48133033
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.46633790
35Absent/shortened dynein arms (HP:0200106)2.46633790
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.45458975
37Intestinal atresia (HP:0011100)2.44071498
38Congenital sensorineural hearing impairment (HP:0008527)2.43896517
39Hyperglycinuria (HP:0003108)2.42108049
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.39130763
41Abnormality of DNA repair (HP:0003254)2.37972097
42Palmar hyperkeratosis (HP:0010765)2.36349308
43Abnormality of the fovea (HP:0000493)2.36185151
44Abnormal biliary tract morphology (HP:0012440)2.33339099
45Bony spicule pigmentary retinopathy (HP:0007737)2.32806297
46Duplication of thumb phalanx (HP:0009942)2.32519494
47Abnormality of glycine metabolism (HP:0010895)2.32196608
48Abnormality of serine family amino acid metabolism (HP:0010894)2.32196608
49Ectopic kidney (HP:0000086)2.31996812
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.30799744
51Intrahepatic cholestasis (HP:0001406)2.30798866
52Attenuation of retinal blood vessels (HP:0007843)2.29274600
53Nephronophthisis (HP:0000090)2.28587325
54Poor head control (HP:0002421)2.27556971
55Absent speech (HP:0001344)2.25649133
56Abnormality of the renal medulla (HP:0100957)2.25305620
57Hypoglycemic seizures (HP:0002173)2.23050987
58Abnormal auditory evoked potentials (HP:0006958)2.23043558
59Meckel diverticulum (HP:0002245)2.22650152
60Median cleft lip (HP:0000161)2.22467650
61Symptomatic seizures (HP:0011145)2.22073635
62Aplasia/Hypoplasia of the fovea (HP:0008060)2.21653290
63Hypoplasia of the fovea (HP:0007750)2.21653290
64Midline defect of the nose (HP:0004122)2.20629432
65Degeneration of anterior horn cells (HP:0002398)2.20402440
66Abnormality of the anterior horn cell (HP:0006802)2.20402440
67Palmoplantar hyperkeratosis (HP:0000972)2.18829707
68Abnormality of the vitamin B12 metabolism (HP:0004341)2.18606899
69Patchy hypopigmentation of hair (HP:0011365)2.18466951
70Plantar hyperkeratosis (HP:0007556)2.16388575
71Abnormality of the preputium (HP:0100587)2.15533488
72Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14909073
73Abnormality of incisor morphology (HP:0011063)2.14078781
74B lymphocytopenia (HP:0010976)2.11801397
75Exercise-induced muscle cramps (HP:0003710)2.11243671
76Proximal tubulopathy (HP:0000114)2.10177249
77Abnormal respiratory motile cilium physiology (HP:0012261)2.09818928
78Lip pit (HP:0100267)2.09752811
79Albinism (HP:0001022)2.09583788
80Abnormality of the ileum (HP:0001549)2.09036889
81Confusion (HP:0001289)2.08554207
82Aplasia/Hypoplasia of the tibia (HP:0005772)2.08504818
83Fair hair (HP:0002286)2.08083083
84Abnormality of alanine metabolism (HP:0010916)2.07096760
85Hyperalaninemia (HP:0003348)2.07096760
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07096760
87Congenital hepatic fibrosis (HP:0002612)2.06487255
88Abnormality of proline metabolism (HP:0010907)2.06477921
89Hydroxyprolinuria (HP:0003080)2.06477921
90Increased serum pyruvate (HP:0003542)2.06439563
91Hyperglycinemia (HP:0002154)2.05821788
92Short tibia (HP:0005736)2.05685548
93Onycholysis (HP:0001806)2.05330135
94Abnormality of nail color (HP:0100643)2.05027672
95Prostate neoplasm (HP:0100787)2.04650411
96Ketoacidosis (HP:0001993)2.04450028
97Decreased lacrimation (HP:0000633)2.04364766
98Abnormality of the parietal bone (HP:0002696)2.02643263
99Curly hair (HP:0002212)2.00390293
100Abnormality of chromosome stability (HP:0003220)2.00310429
101Spondylolisthesis (HP:0003302)1.97583004
102Follicular hyperkeratosis (HP:0007502)1.97474245
103Acute lymphatic leukemia (HP:0006721)1.96953452
104Hyperglycemia (HP:0003074)1.96945179
105Gaze-evoked nystagmus (HP:0000640)1.96135064
106Papillary thyroid carcinoma (HP:0002895)1.95759892
107Abnormality of placental membranes (HP:0011409)1.95258286
108Amniotic constriction ring (HP:0009775)1.95258286
109Alacrima (HP:0000522)1.95234194
110Protruding tongue (HP:0010808)1.94369441
111Abnormality of the antihelix (HP:0009738)1.94208094
112Ankyloglossia (HP:0010296)1.94124004
113Vitreoretinal degeneration (HP:0000655)1.94010999
114Abnormality of the vasculature of the conjunctiva (HP:0008054)1.93506628
115Abnormality of the columella (HP:0009929)1.93353740
116Right ventricular cardiomyopathy (HP:0011663)1.93296560
117Abnormality of serum amino acid levels (HP:0003112)1.92846334
118Abnormality of the labia minora (HP:0012880)1.92091534
119Abnormality of endocrine pancreas physiology (HP:0012093)1.91779386
120Abnormality of the pancreatic islet cells (HP:0006476)1.91779386
121Epileptic encephalopathy (HP:0200134)1.91622884
122Tetraparesis (HP:0002273)1.90039706
123Increased hepatocellular lipid droplets (HP:0006565)1.89697297
124Oligodactyly (HP:0012165)1.89654936
125Abnormality of vitamin metabolism (HP:0100508)1.89411367
126Abnormality of the incisor (HP:0000676)1.88194565
127White forelock (HP:0002211)1.88191682
128Limb hypertonia (HP:0002509)1.88137581
129Thyroiditis (HP:0100646)1.87675936
130Rhabdomyosarcoma (HP:0002859)1.87577008
131Abnormality of the fingertips (HP:0001211)1.87360937
132Absent radius (HP:0003974)1.86632366
133Distal lower limb amyotrophy (HP:0008944)1.86215901
134Facial cleft (HP:0002006)1.85749429
135Abnormality of the carotid arteries (HP:0005344)1.84975043
136Optic nerve hypoplasia (HP:0000609)1.84493518
137Neoplasm of the adrenal gland (HP:0100631)1.84075610
138Postaxial foot polydactyly (HP:0001830)1.83836801
139Dry hair (HP:0011359)1.83518309
140Progressive cerebellar ataxia (HP:0002073)1.83305751
141Supernumerary spleens (HP:0009799)1.82644052
142Ectopic anus (HP:0004397)1.82124887
143Preaxial hand polydactyly (HP:0001177)1.81937565
144Duodenal stenosis (HP:0100867)1.81599254
145Small intestinal stenosis (HP:0012848)1.81599254
146Bifid uvula (HP:0000193)1.81512986
147Steatorrhea (HP:0002570)1.81486763
148Aplasia involving forearm bones (HP:0009822)1.81188792
149Absent forearm bone (HP:0003953)1.81188792
150Blue irides (HP:0000635)1.81039944
151Broad-based gait (HP:0002136)1.81027974
152Anophthalmia (HP:0000528)1.80807953
153Distal lower limb muscle weakness (HP:0009053)1.80801840
154Conjunctival telangiectasia (HP:0000524)1.80748583
155Generalized hypopigmentation of hair (HP:0011358)1.80395966
156Urethral obstruction (HP:0000796)1.80194284
157Abnormal hair laboratory examination (HP:0003328)1.79498934
158Abnormal rod and cone electroretinograms (HP:0008323)1.78781055
159Severe visual impairment (HP:0001141)1.78656546
160Abnormality of macular pigmentation (HP:0008002)1.78640532
161Congenital, generalized hypertrichosis (HP:0004540)1.78562558
162Lipid accumulation in hepatocytes (HP:0006561)1.78328638
163Volvulus (HP:0002580)1.78162949
164Renal cortical cysts (HP:0000803)1.78062451
165Clubbing of toes (HP:0100760)1.77817185
166Abnormality of the duodenum (HP:0002246)1.77362660
167Fat malabsorption (HP:0002630)1.77310984
168Supernumerary ribs (HP:0005815)1.77140278
169Increased corneal curvature (HP:0100692)1.77135370
170Keratoconus (HP:0000563)1.77135370
171Osteomalacia (HP:0002749)1.76224034
172Photophobia (HP:0000613)1.75023165
173Alopecia of scalp (HP:0002293)1.74760969
174Drooling (HP:0002307)1.74405478
175Excessive salivation (HP:0003781)1.74405478
176Nasolacrimal duct obstruction (HP:0000579)1.73489925
177Chorioretinal atrophy (HP:0000533)1.73417946
178Focal seizures (HP:0007359)1.72894453
179Genetic anticipation (HP:0003743)1.71836606
180Supernumerary bones of the axial skeleton (HP:0009144)1.69715880
181Abdominal situs inversus (HP:0003363)1.68790778
182Abnormality of abdominal situs (HP:0011620)1.68790778
183Aplasia/Hypoplasia of the earlobes (HP:0009906)1.68757841
184Pigmentary retinal degeneration (HP:0001146)1.68103162
185Long eyelashes (HP:0000527)1.67346694
186Abnormality of the renal cortex (HP:0011035)1.66541854
187Abnormality of the lacrimal duct (HP:0011481)1.65817761

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.14109971
2NTRK33.35038752
3CASK3.33850861
4FRK3.07650821
5BRD43.05516791
6ACVR1B3.00831721
7EIF2AK32.97096658
8INSRR2.90590646
9EIF2AK22.81605570
10MST42.80825096
11NEK92.80070747
12CDK122.77344930
13CAMK1D2.58805359
14MAP3K122.56594624
15CAMK1G2.49521842
16ZAK2.47708523
17GRK12.44888354
18NEK12.40275977
19BRSK22.28961644
20TRIM282.27579813
21EIF2AK12.03850918
22MAP4K22.03454364
23TRPM71.94466692
24AKT31.84457236
25NUAK11.78272335
26EPHA41.70928586
27PNCK1.66194795
28ERBB31.65712319
29PLK31.58918395
30PDK21.58016236
31MKNK21.54180044
32STK161.53020218
33TGFBR11.52220193
34NEK61.51649562
35CDK31.50240960
36MYLK1.45940453
37TTK1.41159610
38MAPK131.26956583
39IRAK31.26558379
40YES11.26417921
41LATS11.19325659
42WEE11.17542406
43EPHA21.14406858
44SCYL21.12677263
45FLT31.09054753
46SIK21.07299702
47TGFBR21.04795237
48SGK21.03817412
49TLK11.02482484
50PKN11.00466176
51MAP3K20.99244461
52PLK40.98331323
53SRPK10.98089582
54OBSCN0.97853549
55ATR0.97485040
56CSNK1G10.95757517
57CDC42BPA0.95240021
58PRPF4B0.95091511
59MAP3K40.94688952
60TSSK60.94211439
61CHEK20.94207819
62MET0.93495934
63PRKAA20.92229069
64CDK60.91369443
65SGK10.89806635
66PBK0.89373815
67PLK20.88788377
68NLK0.87764595
69WNK10.87520975
70BMPR1B0.85532780
71NTRK20.84310712
72ADRBK20.83003209
73MAP2K70.80359890
74CDK90.80204325
75MAP3K140.79286610
76TEC0.78563701
77GRK70.78522344
78PIK3CG0.76830002
79CSNK1G30.76815413
80FGR0.76172366
81CAMK10.74434571
82BUB10.73940193
83OXSR10.72874948
84CSNK1A1L0.72670998
85ATM0.72017864
86MAP3K130.71559801
87MKNK10.70929062
88MARK20.70716086
89STK380.70399842
90FES0.70335970
91RIPK40.69169504
92FGFR20.68934916
93TXK0.68671650
94STK240.68589363
95STK110.68504868
96TIE10.68251561
97IRAK10.67607592
98TAOK30.66699155
99FGFR10.65020088
100PAK30.63600653
101MAP3K60.63036786
102CDC70.62957127
103ERBB40.62269444
104STK40.61595254
105RPS6KB20.61434336
106AURKB0.60671901
107BLK0.60602626
108PRKG10.58843272
109CAMK2A0.57551185
110CSNK1G20.57244924
111PRKCE0.57192466
112PKN20.56854297
113STK390.56506542
114BCR0.56304019
115MUSK0.55849953
116BCKDK0.55562823
117CAMK2D0.54032892
118STK38L0.53857936
119MAPKAPK50.53626130
120VRK10.53135128
121WNK30.53016364
122CAMK2B0.52478609
123CAMK40.52037152
124SGK30.51996098
125BMPR20.51824123
126GSK3B0.51277000
127MAPK100.50646914
128PRKDC0.50597990
129PAK40.50250375
130STK30.48368830
131CAMKK20.47862716
132MAPK140.46732453
133CSNK1E0.46573936
134MAPK70.46526852
135MAP3K70.46339658
136DMPK0.45865659
137CDK70.45173110
138SGK4940.44901882
139SGK2230.44901882
140AKT20.43943357
141JAK10.41650771
142LMTK20.41579082
143PRKCQ0.41280951
144MST1R0.40982031
145CHEK10.40109947
146EGFR0.39929852
147FGFR30.39691470
148CDK10.39686401
149FER0.39414556
150RPS6KA50.38839056
151MAP2K10.38717740
152PRKD20.38682103
153PLK10.38596631
154PRKCB0.37465594
155CSNK1D0.37434158
156PDGFRA0.36762055
157STK100.36669954
158CLK10.35730351
159ABL10.34108180
160ROCK10.30949623
161CSNK2A10.29060765
162PRKACB0.27824938
163IGF1R0.27357121
164ILK0.24826160

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.89370749
2Nicotine addiction_Homo sapiens_hsa050333.72343557
3Propanoate metabolism_Homo sapiens_hsa006403.63356837
4Protein export_Homo sapiens_hsa030603.36670036
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.20153171
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.00876336
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.91745824
8Fanconi anemia pathway_Homo sapiens_hsa034602.90898140
9Non-homologous end-joining_Homo sapiens_hsa034502.13546144
10Proteasome_Homo sapiens_hsa030502.11422368
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.09618901
12Taste transduction_Homo sapiens_hsa047422.00668105
13Steroid biosynthesis_Homo sapiens_hsa001002.00438472
14Glutamatergic synapse_Homo sapiens_hsa047241.96210090
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90749307
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88075136
17Morphine addiction_Homo sapiens_hsa050321.87447913
18Butanoate metabolism_Homo sapiens_hsa006501.86183840
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84838607
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81240222
21Fatty acid elongation_Homo sapiens_hsa000621.74278333
22Calcium signaling pathway_Homo sapiens_hsa040201.74038742
23Fatty acid metabolism_Homo sapiens_hsa012121.71430031
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.68504236
25Circadian entrainment_Homo sapiens_hsa047131.67167141
26Fatty acid degradation_Homo sapiens_hsa000711.65457432
27Peroxisome_Homo sapiens_hsa041461.61342261
28N-Glycan biosynthesis_Homo sapiens_hsa005101.60488189
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56889765
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.56597933
31Sulfur metabolism_Homo sapiens_hsa009201.56263600
32Salivary secretion_Homo sapiens_hsa049701.51610079
33Serotonergic synapse_Homo sapiens_hsa047261.51328669
34Pyruvate metabolism_Homo sapiens_hsa006201.49081196
35Nucleotide excision repair_Homo sapiens_hsa034201.47366838
36Vitamin B6 metabolism_Homo sapiens_hsa007501.46182078
37Lysine degradation_Homo sapiens_hsa003101.44286100
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.43544797
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.42529034
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40965662
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36810429
42Homologous recombination_Homo sapiens_hsa034401.36183336
43Selenocompound metabolism_Homo sapiens_hsa004501.31284222
44Basal cell carcinoma_Homo sapiens_hsa052171.30190931
45cAMP signaling pathway_Homo sapiens_hsa040241.28383228
46Insulin secretion_Homo sapiens_hsa049111.25060135
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24242778
48RNA degradation_Homo sapiens_hsa030181.24016130
49Axon guidance_Homo sapiens_hsa043601.22672239
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22576156
51Inositol phosphate metabolism_Homo sapiens_hsa005621.22130925
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19157951
53GABAergic synapse_Homo sapiens_hsa047271.17894040
54Type II diabetes mellitus_Homo sapiens_hsa049301.16038450
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.14451828
56Amphetamine addiction_Homo sapiens_hsa050311.13715430
57Caffeine metabolism_Homo sapiens_hsa002321.13364481
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.12453778
59beta-Alanine metabolism_Homo sapiens_hsa004101.12311603
60RNA polymerase_Homo sapiens_hsa030201.11826914
61Vitamin digestion and absorption_Homo sapiens_hsa049771.11030954
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10985630
63Tryptophan metabolism_Homo sapiens_hsa003801.09536647
64Carbon metabolism_Homo sapiens_hsa012001.09291662
65Sphingolipid metabolism_Homo sapiens_hsa006001.07424899
66RNA transport_Homo sapiens_hsa030131.06145389
67Circadian rhythm_Homo sapiens_hsa047101.06070591
68Hedgehog signaling pathway_Homo sapiens_hsa043401.04818274
69Glutathione metabolism_Homo sapiens_hsa004801.03312707
70Cell cycle_Homo sapiens_hsa041101.02925481
71Renin-angiotensin system_Homo sapiens_hsa046140.99808791
72Long-term potentiation_Homo sapiens_hsa047200.99077404
73ABC transporters_Homo sapiens_hsa020100.97398253
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97290491
75ECM-receptor interaction_Homo sapiens_hsa045120.96232196
76DNA replication_Homo sapiens_hsa030300.95174215
77Long-term depression_Homo sapiens_hsa047300.94000814
78Cholinergic synapse_Homo sapiens_hsa047250.93365095
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93357728
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93292712
81Renin secretion_Homo sapiens_hsa049240.92692827
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91660978
83Wnt signaling pathway_Homo sapiens_hsa043100.91631964
84Dorso-ventral axis formation_Homo sapiens_hsa043200.90198791
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89180069
86Other glycan degradation_Homo sapiens_hsa005110.85715611
87Choline metabolism in cancer_Homo sapiens_hsa052310.84451842
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83216251
89Dilated cardiomyopathy_Homo sapiens_hsa054140.82494592
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82277203
91Retinol metabolism_Homo sapiens_hsa008300.82219120
92Cocaine addiction_Homo sapiens_hsa050300.81599662
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.80760429
94Pyrimidine metabolism_Homo sapiens_hsa002400.80706371
95Pancreatic secretion_Homo sapiens_hsa049720.79843816
96Ether lipid metabolism_Homo sapiens_hsa005650.79551345
97Dopaminergic synapse_Homo sapiens_hsa047280.79522251
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.77457420
99Oxytocin signaling pathway_Homo sapiens_hsa049210.77385200
100Mineral absorption_Homo sapiens_hsa049780.77074707
101Systemic lupus erythematosus_Homo sapiens_hsa053220.76827669
102Regulation of autophagy_Homo sapiens_hsa041400.75720569
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75443957
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.73513969
105Olfactory transduction_Homo sapiens_hsa047400.72711664
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72050182
107Ovarian steroidogenesis_Homo sapiens_hsa049130.71216927
108* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71209908
109* Metabolic pathways_Homo sapiens_hsa011000.69096290
110Ras signaling pathway_Homo sapiens_hsa040140.68446439
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67517954
112ErbB signaling pathway_Homo sapiens_hsa040120.66937288
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.66838073
114Autoimmune thyroid disease_Homo sapiens_hsa053200.65453195
115Melanoma_Homo sapiens_hsa052180.65313277
116MicroRNAs in cancer_Homo sapiens_hsa052060.65277929
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63069801
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62926707
119Basal transcription factors_Homo sapiens_hsa030220.62629458
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62042253
121MAPK signaling pathway_Homo sapiens_hsa040100.61916333
122Adherens junction_Homo sapiens_hsa045200.61635361
123Protein digestion and absorption_Homo sapiens_hsa049740.61431793
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61193984
125Asthma_Homo sapiens_hsa053100.60848165
126Melanogenesis_Homo sapiens_hsa049160.60278427
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60184983
128Arginine and proline metabolism_Homo sapiens_hsa003300.57699582
129Mismatch repair_Homo sapiens_hsa034300.57619213
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57576882
131Chemical carcinogenesis_Homo sapiens_hsa052040.57155176
132One carbon pool by folate_Homo sapiens_hsa006700.56859063
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55752663
134mRNA surveillance pathway_Homo sapiens_hsa030150.55013620
135Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54641794
136Rap1 signaling pathway_Homo sapiens_hsa040150.54604643
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54599896
138Folate biosynthesis_Homo sapiens_hsa007900.53683832
139Oocyte meiosis_Homo sapiens_hsa041140.53505287
140Lysosome_Homo sapiens_hsa041420.53025116
141African trypanosomiasis_Homo sapiens_hsa051430.52937920
142GnRH signaling pathway_Homo sapiens_hsa049120.51482711
143Fat digestion and absorption_Homo sapiens_hsa049750.51303725
144Hematopoietic cell lineage_Homo sapiens_hsa046400.50042552
145Gastric acid secretion_Homo sapiens_hsa049710.49772995
146Alcoholism_Homo sapiens_hsa050340.49422734
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47947585
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47790391
149Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47330419
150Pathways in cancer_Homo sapiens_hsa052000.46726071
151Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46052799
152Steroid hormone biosynthesis_Homo sapiens_hsa001400.45337832
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.45257230
154Prostate cancer_Homo sapiens_hsa052150.45052989
155Intestinal immune network for IgA production_Homo sapiens_hsa046720.43950459
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43696204
157Oxidative phosphorylation_Homo sapiens_hsa001900.43526647
158Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42716969
159Drug metabolism - other enzymes_Homo sapiens_hsa009830.41802462
160p53 signaling pathway_Homo sapiens_hsa041150.41492703
161TGF-beta signaling pathway_Homo sapiens_hsa043500.41163051
162Arachidonic acid metabolism_Homo sapiens_hsa005900.40555182
163Purine metabolism_Homo sapiens_hsa002300.40553437
164Nitrogen metabolism_Homo sapiens_hsa009100.40018612
165Base excision repair_Homo sapiens_hsa034100.39858225
166Small cell lung cancer_Homo sapiens_hsa052220.39402921
167SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36655036
168Complement and coagulation cascades_Homo sapiens_hsa046100.36533573
169Starch and sucrose metabolism_Homo sapiens_hsa005000.35735843
170Biosynthesis of amino acids_Homo sapiens_hsa012300.33760010
171Tight junction_Homo sapiens_hsa045300.33614024
172Histidine metabolism_Homo sapiens_hsa003400.29315329
173Spliceosome_Homo sapiens_hsa030400.27679427

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