PIGO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein is involved in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least three alternatively spliced transcripts encoding two distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1amyloid precursor protein catabolic process (GO:0042987)4.89097329
2retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.66440193
3lysine catabolic process (GO:0006554)4.05551812
4lysine metabolic process (GO:0006553)4.05551812
5folic acid metabolic process (GO:0046655)4.01097325
6hemidesmosome assembly (GO:0031581)3.94982299
7desmosome organization (GO:0002934)3.87364728
8GDP-mannose metabolic process (GO:0019673)3.78950881
9regulation of cholesterol homeostasis (GO:2000188)3.75689043
10snRNA metabolic process (GO:0016073)3.73544274
11glycine metabolic process (GO:0006544)3.71301440
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.68777457
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.68777457
14negative regulation of histone methylation (GO:0031061)3.61575332
15folic acid-containing compound biosynthetic process (GO:0009396)3.60200004
16regulation of translational fidelity (GO:0006450)3.59128014
17pre-miRNA processing (GO:0031054)3.55458408
18glucose catabolic process (GO:0006007)3.54023230
19basement membrane organization (GO:0071711)3.53484613
20pentose-phosphate shunt (GO:0006098)3.51715550
21snRNA processing (GO:0016180)3.50407932
22peptidyl-arginine omega-N-methylation (GO:0035247)3.40160463
232-oxoglutarate metabolic process (GO:0006103)3.39504494
24regulation of gamma-delta T cell differentiation (GO:0045586)3.39456114
25COPII vesicle coating (GO:0048208)3.38781784
26glucose 6-phosphate metabolic process (GO:0051156)3.37182827
27membrane protein ectodomain proteolysis (GO:0006509)3.36136713
28amyloid precursor protein metabolic process (GO:0042982)3.31458771
29proline biosynthetic process (GO:0006561)3.30877399
30regulation of cholesterol biosynthetic process (GO:0045540)3.30675701
31positive regulation of triglyceride biosynthetic process (GO:0010867)3.24590311
32positive regulation of histone deacetylation (GO:0031065)3.23730408
33L-alpha-amino acid transmembrane transport (GO:1902475)3.23655014
34NADPH regeneration (GO:0006740)3.22685930
35endoplasmic reticulum unfolded protein response (GO:0030968)3.16241274
36epithelial cell differentiation involved in prostate gland development (GO:0060742)3.15243581
37antigen processing and presentation of endogenous antigen (GO:0019883)3.13169291
38nucleobase biosynthetic process (GO:0046112)3.12394787
39regulation of water loss via skin (GO:0033561)3.07911651
40urea cycle (GO:0000050)3.06595987
41serine family amino acid catabolic process (GO:0009071)3.06426069
42semaphorin-plexin signaling pathway (GO:0071526)3.05348426
43aspartate family amino acid catabolic process (GO:0009068)3.03523784
44ER-nucleus signaling pathway (GO:0006984)3.02609517
45valine metabolic process (GO:0006573)3.01968915
46cellular response to unfolded protein (GO:0034620)3.01300309
47amino-acid betaine metabolic process (GO:0006577)3.00637108
48activation of Rac GTPase activity (GO:0032863)2.99447798
49endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.99338494
50membrane protein intracellular domain proteolysis (GO:0031293)2.97466194
51tRNA methylation (GO:0030488)2.96255431
52Golgi transport vesicle coating (GO:0048200)2.95028270
53COPI coating of Golgi vesicle (GO:0048205)2.95028270
54epithelial cell-cell adhesion (GO:0090136)2.94854656
55regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94831569
56glutamine family amino acid biosynthetic process (GO:0009084)2.92146609
57bundle of His cell to Purkinje myocyte communication (GO:0086069)2.91576415
58regulation of translational termination (GO:0006449)2.91388465
59vesicle coating (GO:0006901)2.91319623
60negative regulation of cell size (GO:0045792)2.91272820
61apoptotic process involved in morphogenesis (GO:0060561)2.89968698
62L-serine metabolic process (GO:0006563)2.89743085
63regulation of gamma-delta T cell activation (GO:0046643)2.88263588
64cysteine metabolic process (GO:0006534)2.88217478
654-hydroxyproline metabolic process (GO:0019471)2.86290312
66serine family amino acid metabolic process (GO:0009069)2.85572229
67tricarboxylic acid metabolic process (GO:0072350)2.85043875
68negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.82944683
69cellular response to topologically incorrect protein (GO:0035967)2.82933900
70serine family amino acid biosynthetic process (GO:0009070)2.81167313
71peptidyl-asparagine modification (GO:0018196)2.80846984
72protein localization to kinetochore (GO:0034501)2.80206859
73protein N-linked glycosylation via asparagine (GO:0018279)2.79726143
74fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.78615391
75purine nucleobase biosynthetic process (GO:0009113)2.78599149
76kynurenine metabolic process (GO:0070189)2.78278240
77nuclear pore organization (GO:0006999)2.77281863
78urea metabolic process (GO:0019627)2.76595956
79nuclear envelope reassembly (GO:0031468)2.75791657
80mitotic nuclear envelope reassembly (GO:0007084)2.75791657
81L-serine transport (GO:0015825)2.75563356
82protein localization to endosome (GO:0036010)2.75525294
83dicarboxylic acid biosynthetic process (GO:0043650)2.74713134
84fatty acid homeostasis (GO:0055089)2.74217119
85protein N-linked glycosylation (GO:0006487)2.71904542
86mitotic nuclear envelope disassembly (GO:0007077)2.71152752
87antigen processing and presentation via MHC class Ib (GO:0002475)2.71111883
88regulation of nuclease activity (GO:0032069)2.71058561
89protein localization to chromosome, centromeric region (GO:0071459)2.70568362
90positive thymic T cell selection (GO:0045059)2.70549398
91proline metabolic process (GO:0006560)2.70402735
92positive regulation of gamma-delta T cell activation (GO:0046645)2.69908400
93regulation of cholesterol metabolic process (GO:0090181)2.69405690
94DNA unwinding involved in DNA replication (GO:0006268)2.68897342
95cell-substrate junction assembly (GO:0007044)2.68816106
96regulation of glucose import in response to insulin stimulus (GO:2001273)2.68394914
97regulation of histone H3-K27 methylation (GO:0061085)2.67841059
98long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.67668968
99mitotic G1 DNA damage checkpoint (GO:0031571)2.67357333
100nuclear pore complex assembly (GO:0051292)2.66885194
101intracellular estrogen receptor signaling pathway (GO:0030520)2.66001958
102carnitine metabolic process (GO:0009437)2.65661147
103maternal placenta development (GO:0001893)2.64547996
104branching involved in mammary gland duct morphogenesis (GO:0060444)2.64535806
105negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.64283635
106tetrahydrofolate metabolic process (GO:0046653)2.63940679
107histone H4-K12 acetylation (GO:0043983)2.63824484
108trophectodermal cell differentiation (GO:0001829)2.63809579
109alpha-linolenic acid metabolic process (GO:0036109)2.63683591
110positive regulation of keratinocyte differentiation (GO:0045618)2.63407510
111NADH metabolic process (GO:0006734)2.61926784
112folic acid-containing compound metabolic process (GO:0006760)2.61853580
113regulation of chromatin binding (GO:0035561)2.61732831
114peptidyl-arginine N-methylation (GO:0035246)2.60985254
115peptidyl-arginine methylation (GO:0018216)2.60985254
116regulation of fatty acid beta-oxidation (GO:0031998)2.60971378
117skin morphogenesis (GO:0043589)2.60911852
118oxaloacetate metabolic process (GO:0006107)2.60232943
119mitochondrial DNA metabolic process (GO:0032042)2.60023487
120negative regulation of cholesterol transport (GO:0032375)2.59029423
121negative regulation of sterol transport (GO:0032372)2.59029423
122planar cell polarity pathway involved in neural tube closure (GO:0090179)2.58949997
123monosaccharide biosynthetic process (GO:0046364)2.58637929
124fatty-acyl-CoA biosynthetic process (GO:0046949)2.58597311
125histone arginine methylation (GO:0034969)2.58543333
126positive regulation of triglyceride metabolic process (GO:0090208)2.58210760
127embryonic process involved in female pregnancy (GO:0060136)2.58052364
128protein retention in ER lumen (GO:0006621)2.58049083
129nuclear envelope disassembly (GO:0051081)2.57782351
130membrane disassembly (GO:0030397)2.57782351
131sphingosine metabolic process (GO:0006670)2.57040086
132negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.56021936
133peptidyl-lysine dimethylation (GO:0018027)2.55859510
134adherens junction assembly (GO:0034333)2.55240022
135IMP biosynthetic process (GO:0006188)2.54781501
136cell-substrate adherens junction assembly (GO:0007045)2.53829543
137focal adhesion assembly (GO:0048041)2.53829543
138chromatin silencing (GO:0006342)2.53796763
139protein maturation by protein folding (GO:0022417)2.52254274
140heterochromatin organization (GO:0070828)2.51816746
141homocysteine metabolic process (GO:0050667)2.51406254
142gene silencing (GO:0016458)2.50959711
143regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.50811026
144regulation of apoptotic process involved in morphogenesis (GO:1902337)2.50711168
145protein insertion into membrane (GO:0051205)2.50603528
146chaperone mediated protein folding requiring cofactor (GO:0051085)2.50214571
147spliceosomal tri-snRNP complex assembly (GO:0000244)2.49766506
148regulation of histone H3-K9 methylation (GO:0051570)2.49750650
149biotin metabolic process (GO:0006768)2.49490921
150endothelial cell chemotaxis (GO:0035767)2.49179326
151activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.47967411
152sulfur amino acid catabolic process (GO:0000098)2.47308462
153glutathione biosynthetic process (GO:0006750)2.45996616
154positive regulation of nuclease activity (GO:0032075)2.45340852
155negative regulation of viral release from host cell (GO:1902187)2.45148716
156thymic T cell selection (GO:0045061)2.44927087
157positive regulation of Cdc42 GTPase activity (GO:0043089)2.44522585
158one-carbon metabolic process (GO:0006730)2.44252508
159mannose metabolic process (GO:0006013)2.43809907
160maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.43461238
161CDP-diacylglycerol metabolic process (GO:0046341)2.42855865
162response to endoplasmic reticulum stress (GO:0034976)2.42590633
163cell adhesion mediated by integrin (GO:0033627)2.41967624
164regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.41935140
165amino-acid betaine transport (GO:0015838)2.41391067
166carnitine transport (GO:0015879)2.41391067
167DNA duplex unwinding (GO:0032508)2.41118250
168post-embryonic morphogenesis (GO:0009886)2.41117313
169ethanol oxidation (GO:0006069)2.40681583
170nucleotide-sugar biosynthetic process (GO:0009226)2.39704433
171regulation of gene silencing by miRNA (GO:0060964)2.39512619
172regulation of gene silencing by RNA (GO:0060966)2.39512619
173regulation of posttranscriptional gene silencing (GO:0060147)2.39512619
174formation of translation preinitiation complex (GO:0001731)2.39314792
175galactose catabolic process (GO:0019388)2.39200925
176tricarboxylic acid cycle (GO:0006099)2.36813839
177DNA geometric change (GO:0032392)2.36728530
178positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.35138972
179nuclear envelope organization (GO:0006998)2.34789421
180negative regulation of mRNA metabolic process (GO:1903312)2.33435814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.73564697
2MYC_22102868_ChIP-Seq_BL_Human3.26679179
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.01183411
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95228691
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.72386676
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.49438902
7ZNF263_19887448_ChIP-Seq_K562_Human2.45893293
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.23700399
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.18583457
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01790245
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00313249
12RXR_22158963_ChIP-Seq_LIVER_Mouse1.99384574
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95529658
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.95377700
15MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92398161
16VDR_21846776_ChIP-Seq_THP-1_Human1.90045889
17EGR1_19374776_ChIP-ChIP_THP-1_Human1.88070137
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.86499866
19CIITA_25753668_ChIP-Seq_RAJI_Human1.81193648
20TCF7_22412390_ChIP-Seq_EML_Mouse1.79980467
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76916430
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76844246
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66098846
24LXR_22292898_ChIP-Seq_THP-1_Human1.65728795
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.62657949
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.59752635
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58890464
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58408154
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58127425
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57976189
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56785241
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53485267
33KDM2B_26808549_Chip-Seq_DND41_Human1.53287079
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52801947
35* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49547726
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.49527670
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49164381
38* P68_20966046_ChIP-Seq_HELA_Human1.48940781
39CLOCK_20551151_ChIP-Seq_293T_Human1.47014849
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.46487755
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46437470
42MAF_26560356_Chip-Seq_TH1_Human1.45890778
43DCP1A_22483619_ChIP-Seq_HELA_Human1.44256787
44UTX_26944678_Chip-Seq_JUKART_Human1.43040302
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.40048998
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.39190315
47XRN2_22483619_ChIP-Seq_HELA_Human1.39147303
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36586937
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.33892145
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33780252
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32729608
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32241755
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.31388845
54TFEB_21752829_ChIP-Seq_HELA_Human1.30736888
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.30625626
56KDM5A_27292631_Chip-Seq_BREAST_Human1.30523492
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30000160
58* ELF1_20517297_ChIP-Seq_JURKAT_Human1.29508952
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27644707
60TP53_22127205_ChIP-Seq_IMR90_Human1.27401160
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26007558
62* RARB_24833708_ChIP-Seq_LIVER_Mouse1.22839439
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22574142
64RACK7_27058665_Chip-Seq_MCF-7_Human1.22225480
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21444495
66* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21112102
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20961625
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20248543
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19549671
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.19426290
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18753395
72PKCTHETA_26484144_Chip-Seq_BREAST_Human1.18185217
73* BCOR_27268052_Chip-Seq_Bcells_Human1.17937887
74* PHF8_20622854_ChIP-Seq_HELA_Human1.17402817
75* RARA_24833708_ChIP-Seq_LIVER_Mouse1.16860031
76MAF_26560356_Chip-Seq_TH2_Human1.16692902
77ATF3_27146783_Chip-Seq_COLON_Human1.16660454
78* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15475215
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15455669
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14593946
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14586142
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14230535
83* BCL6_27268052_Chip-Seq_Bcells_Human1.14173733
84NCOR1_26117541_ChIP-Seq_K562_Human1.13273989
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12858997
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11969874
87* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11630691
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11545400
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.11462631
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11109072
91* GABP_19822575_ChIP-Seq_HepG2_Human1.11059681
92ETS1_20019798_ChIP-Seq_JURKAT_Human1.10770160
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10384246
94NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10176797
95MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10092247
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09615619
97P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08736091
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08230899
99CHD1_26751641_Chip-Seq_LNCaP_Human1.08015669
100MYB_26560356_Chip-Seq_TH1_Human1.06520693
101* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05867564
102* TET1_21451524_ChIP-Seq_MESCs_Mouse1.05549436
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05044095
104E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04627844
105GATA6_25053715_ChIP-Seq_YYC3_Human1.04518840
106E2F1_21310950_ChIP-Seq_MCF-7_Human1.04220660
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03771258
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03367119
109SA1_27219007_Chip-Seq_ERYTHROID_Human1.03264584
110STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03103954
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01981613
112* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01950256
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99675561
114CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99604721
115UBF1/2_26484160_Chip-Seq_HMECs_Human0.99550195
116AR_21909140_ChIP-Seq_LNCAP_Human0.99276604
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99202828
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98869751
119CREB1_26743006_Chip-Seq_LNCaP_Human0.98844956
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98304033
121FOXP3_21729870_ChIP-Seq_TREG_Human0.97953097
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97667564
123* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97642080
124ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97574267
125CTCF_21964334_Chip-Seq_Bcells_Human0.96849194
126ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95522265
127SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95439764
128SMC4_20622854_ChIP-Seq_HELA_Human0.94100526
129YY1_21170310_ChIP-Seq_MESCs_Mouse0.94031122
130* FOXP1_21924763_ChIP-Seq_HESCs_Human0.93754927
131BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93572299
132THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93556271
133SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93506708
134MYB_26560356_Chip-Seq_TH2_Human0.93076411
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92966031
136CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92890018
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91211414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.51199796
2MP0005360_urolithiasis3.30408296
3MP0005058_abnormal_lysosome_morphology3.08571289
4MP0009840_abnormal_foam_cell2.92592384
5MP0005365_abnormal_bile_salt2.91877374
6MP0003693_abnormal_embryo_hatching2.75769378
7MP0004858_abnormal_nervous_system2.65298790
8MP0010352_gastrointestinal_tract_polyps2.46359767
9MP0005085_abnormal_gallbladder_physiolo2.43784267
10MP0003111_abnormal_nucleus_morphology2.29698270
11MP0005501_abnormal_skin_physiology2.29035020
12MP0005451_abnormal_body_composition2.27236450
13MP0003806_abnormal_nucleotide_metabolis2.24559458
14MP0002877_abnormal_melanocyte_morpholog2.16318612
15MP0000537_abnormal_urethra_morphology2.13806452
16MP0003252_abnormal_bile_duct2.10875966
17MP0010030_abnormal_orbit_morphology2.08805420
18MP0001666_abnormal_nutrient_absorption2.01361732
19MP0010234_abnormal_vibrissa_follicle1.92617115
20MP0003763_abnormal_thymus_physiology1.92583337
21MP0003453_abnormal_keratinocyte_physiol1.89487801
22MP0004957_abnormal_blastocyst_morpholog1.89388226
23MP0008961_abnormal_basal_metabolism1.89296288
24MP0003300_gastrointestinal_ulcer1.88305347
25MP0003705_abnormal_hypodermis_morpholog1.86783353
26MP0008260_abnormal_autophagy1.86569345
27MP0003646_muscle_fatigue1.85765563
28MP0003172_abnormal_lysosome_physiology1.84670604
29MP0002254_reproductive_system_inflammat1.77828681
30MP0005670_abnormal_white_adipose1.76212166
31MP0002060_abnormal_skin_morphology1.74488839
32MP0004264_abnormal_extraembryonic_tissu1.73026446
33MP0001216_abnormal_epidermal_layer1.72863594
34MP0001730_embryonic_growth_arrest1.72263026
35MP0005257_abnormal_intraocular_pressure1.71146647
36MP0009780_abnormal_chondrocyte_physiolo1.69817644
37MP0003077_abnormal_cell_cycle1.66640171
38MP0010329_abnormal_lipoprotein_level1.62673450
39MP0000566_synostosis1.60992288
40MP0000579_abnormal_nail_morphology1.59750357
41MP0002396_abnormal_hematopoietic_system1.58350634
42MP0010094_abnormal_chromosome_stability1.58037305
43MP0001661_extended_life_span1.56530763
44MP0000609_abnormal_liver_physiology1.54748072
45MP0004272_abnormal_basement_membrane1.53087511
46MP0005623_abnormal_meninges_morphology1.50337562
47MP0000467_abnormal_esophagus_morphology1.48496556
48MP0002098_abnormal_vibrissa_morphology1.46544788
49MP0005083_abnormal_biliary_tract1.45762597
50MP0003866_abnormal_defecation1.43809522
51MP0005332_abnormal_amino_acid1.42156725
52MP0010678_abnormal_skin_adnexa1.41995358
53MP0000383_abnormal_hair_follicle1.39263482
54MP0002653_abnormal_ependyma_morphology1.39040269
55MP0003329_amyloid_beta_deposits1.38599335
56MP0008875_abnormal_xenobiotic_pharmacok1.35850128
57MP0000377_abnormal_hair_follicle1.34113701
58MP0000013_abnormal_adipose_tissue1.32600849
59MP0000858_altered_metastatic_potential1.32394320
60MP0005076_abnormal_cell_differentiation1.31947410
61MP0001672_abnormal_embryogenesis/_devel1.28104829
62MP0005380_embryogenesis_phenotype1.28104829
63MP0009643_abnormal_urine_homeostasis1.26397908
64MP0006036_abnormal_mitochondrial_physio1.25854200
65MP0010630_abnormal_cardiac_muscle1.24182361
66MP0008438_abnormal_cutaneous_collagen1.23209233
67MP0003984_embryonic_growth_retardation1.22732448
68MP0002080_prenatal_lethality1.22308420
69MP0002269_muscular_atrophy1.22203941
70MP0002088_abnormal_embryonic_growth/wei1.21869594
71MP0010771_integument_phenotype1.20337177
72MP0000627_abnormal_mammary_gland1.20122682
73MP0004084_abnormal_cardiac_muscle1.18601350
74MP0002086_abnormal_extraembryonic_tissu1.18455060
75MP0003091_abnormal_cell_migration1.17733533
76MP0004782_abnormal_surfactant_physiolog1.16274063
77MP0001697_abnormal_embryo_size1.15430016
78MP0005220_abnormal_exocrine_pancreas1.14109747
79MP0003566_abnormal_cell_adhesion1.14043388
80MP0000350_abnormal_cell_proliferation1.12114809
81MP0001873_stomach_inflammation1.11409503
82MP0005023_abnormal_wound_healing1.09763253
83MP0009672_abnormal_birth_weight1.09395458
84MP0005319_abnormal_enzyme/_coenzyme1.08489866
85MP0005409_darkened_coat_color1.08436449
86MP0009053_abnormal_anal_canal1.08304654
87MP0005330_cardiomyopathy1.07782163
88MP0004808_abnormal_hematopoietic_stem1.07455513
89MP0004185_abnormal_adipocyte_glucose1.06553579
90MP0002822_catalepsy1.06220128
91MP0000703_abnormal_thymus_morphology1.05849581
92MP0009931_abnormal_skin_appearance1.05812452
93MP0005621_abnormal_cell_physiology1.04622635
94MP0003283_abnormal_digestive_organ1.04009463
95MP0004233_abnormal_muscle_weight1.03688399
96MP0002722_abnormal_immune_system1.02489346
97MP0003303_peritoneal_inflammation1.01814663
98MP0001243_abnormal_dermal_layer1.01190875
99MP0004019_abnormal_vitamin_homeostasis1.01150335
100MP0003191_abnormal_cellular_cholesterol1.00788731
101MP0002009_preneoplasia1.00669825
102MP0002084_abnormal_developmental_patter1.00399760
103MP0009278_abnormal_bone_marrow1.00119151
104MP0000490_abnormal_crypts_of0.99865474
105MP0002398_abnormal_bone_marrow0.99687300
106MP0000598_abnormal_liver_morphology0.99595982
107MP0004043_abnormal_pH_regulation0.99094461
108MP0003183_abnormal_peptide_metabolism0.97716830
109MP0001881_abnormal_mammary_gland0.96716058
110MP0008058_abnormal_DNA_repair0.95930295
111MP0000689_abnormal_spleen_morphology0.94479993
112MP0002234_abnormal_pharynx_morphology0.94464144
113MP0004197_abnormal_fetal_growth/weight/0.93919238
114MP0005666_abnormal_adipose_tissue0.92928436
115MP0010307_abnormal_tumor_latency0.92762951
116MP0000685_abnormal_immune_system0.92746113
117MP0002019_abnormal_tumor_incidence0.91921825
118MP0002085_abnormal_embryonic_tissue0.91811290
119MP0002118_abnormal_lipid_homeostasis0.91249839
120MP0010155_abnormal_intestine_physiology0.90549111
121MP0005384_cellular_phenotype0.90099651
122MP0003221_abnormal_cardiomyocyte_apopto0.89061126
123MP0002089_abnormal_postnatal_growth/wei0.88818826
124MP0004947_skin_inflammation0.87805010
125MP0000678_abnormal_parathyroid_gland0.85858203
126MP0002909_abnormal_adrenal_gland0.85513069
127MP0000613_abnormal_salivary_gland0.84513535
128MP0005375_adipose_tissue_phenotype0.84339849
129MP0003567_abnormal_fetal_cardiomyocyte0.84077985
130MP0003115_abnormal_respiratory_system0.83132325
131MP0006035_abnormal_mitochondrial_morpho0.82894896
132MP0002136_abnormal_kidney_physiology0.82403386
133MP0003119_abnormal_digestive_system0.82076636
134MP0004087_abnormal_muscle_fiber0.81410812
135MP0000313_abnormal_cell_death0.81406129
136MP0005397_hematopoietic_system_phenotyp0.81064120
137MP0001545_abnormal_hematopoietic_system0.81064120
138MP0000733_abnormal_muscle_development0.81018336
139MP0001800_abnormal_humoral_immune0.80551809
140MP0004130_abnormal_muscle_cell0.80467660
141MP0000762_abnormal_tongue_morphology0.79989692
142MP0004215_abnormal_myocardial_fiber0.79634050
143MP0002796_impaired_skin_barrier0.79239276
144MP0005266_abnormal_metabolism0.79171130
145MP0001929_abnormal_gametogenesis0.79055283
146MP0001849_ear_inflammation0.77666948
147MP0002249_abnormal_larynx_morphology0.76410415
148MP0000358_abnormal_cell_content/0.75669068
149MP0000003_abnormal_adipose_tissue0.75642748
150MP0000465_gastrointestinal_hemorrhage0.75619810
151MP0001764_abnormal_homeostasis0.75573998
152MP0003786_premature_aging0.73873857
153MP0002166_altered_tumor_susceptibility0.73718991
154MP0000367_abnormal_coat/_hair0.73679555
155MP0000462_abnormal_digestive_system0.73628113
156MP0000477_abnormal_intestine_morphology0.72846841
157MP0002896_abnormal_bone_mineralization0.72478980
158MP0008932_abnormal_embryonic_tissue0.70731058
159MP0002111_abnormal_tail_morphology0.70321749
160MP0000538_abnormal_urinary_bladder0.69574530

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)4.01463554
2Abnormality of the distal phalanges of the toes (HP:0010182)3.89046524
3Short nail (HP:0001799)3.85060235
4Cervical subluxation (HP:0003308)3.61527362
5Upper limb amyotrophy (HP:0009129)3.56643071
6Distal upper limb amyotrophy (HP:0007149)3.56643071
7Flat acetabular roof (HP:0003180)3.48787687
8J-shaped sella turcica (HP:0002680)3.16582684
9Abnormality of glycine metabolism (HP:0010895)3.13713602
10Abnormality of serine family amino acid metabolism (HP:0010894)3.13713602
11Ependymoma (HP:0002888)3.13639295
12Progressive muscle weakness (HP:0003323)3.09848972
13Hypoglycemic coma (HP:0001325)3.07682327
14Myoglobinuria (HP:0002913)3.06065215
15Ketosis (HP:0001946)3.05405497
16Gout (HP:0001997)3.00025922
17Limb hypertonia (HP:0002509)2.96215380
18Abnormality of the lower motor neuron (HP:0002366)2.95051031
19Nasal polyposis (HP:0100582)2.91062840
20Hyperglycinemia (HP:0002154)2.90148500
21Entropion (HP:0000621)2.85833521
22Premature rupture of membranes (HP:0001788)2.85484900
23Broad face (HP:0000283)2.82260075
24Vertebral compression fractures (HP:0002953)2.82114815
25Abnormal hair laboratory examination (HP:0003328)2.81835512
26Hyperammonemia (HP:0001987)2.80475241
27Natal tooth (HP:0000695)2.76704902
28Hypoplasia of the capital femoral epiphysis (HP:0003090)2.74054996
29Cerebral aneurysm (HP:0004944)2.73173870
30Ragged-red muscle fibers (HP:0003200)2.67049360
31Mucopolysacchariduria (HP:0008155)2.66070107
32Urinary glycosaminoglycan excretion (HP:0003541)2.66070107
33Ulnar bowing (HP:0003031)2.65643638
34Basal cell carcinoma (HP:0002671)2.61685573
35Bundle branch block (HP:0011710)2.60413093
36Hemorrhage of the eye (HP:0011885)2.58088003
37Multiple enchondromatosis (HP:0005701)2.56552325
38Abnormality of monocarboxylic acid metabolism (HP:0010996)2.55554899
39Abnormality of sulfur amino acid metabolism (HP:0004339)2.54524894
40Abnormality of mucopolysaccharide metabolism (HP:0011020)2.52841102
41Abnormality of polysaccharide metabolism (HP:0011012)2.52841102
42Abnormality of glycosaminoglycan metabolism (HP:0004371)2.52841102
43Ketoacidosis (HP:0001993)2.52514345
44Stridor (HP:0010307)2.52216809
45Advanced eruption of teeth (HP:0006288)2.49490247
46Dysmetric saccades (HP:0000641)2.46193029
47Increased cerebral lipofuscin (HP:0011813)2.44725472
48Pili torti (HP:0003777)2.42916104
49Hyperacusis (HP:0010780)2.41553850
50Ventricular tachycardia (HP:0004756)2.39714816
51Flattened epiphyses (HP:0003071)2.39595012
52Late onset (HP:0003584)2.38723337
53Abnormality of the nasal mucosa (HP:0000433)2.38216114
54Xanthomatosis (HP:0000991)2.35811572
55Interstitial pulmonary disease (HP:0006530)2.34804411
56Abdominal distention (HP:0003270)2.33340249
57Hypokinesia (HP:0002375)2.31330899
58Prolonged neonatal jaundice (HP:0006579)2.31198056
59Right ventricular cardiomyopathy (HP:0011663)2.30486081
60Poikiloderma (HP:0001029)2.30296119
61Prominent nose (HP:0000448)2.26912449
62Increased neuronal autofluorescent lipopigment (HP:0002074)2.25600997
63Intrahepatic cholestasis (HP:0001406)2.25285748
64Testicular atrophy (HP:0000029)2.25157483
65Elfin facies (HP:0004428)2.21881843
66Microvesicular hepatic steatosis (HP:0001414)2.21687287
67Rhabdomyolysis (HP:0003201)2.21387279
68Septate vagina (HP:0001153)2.21283455
69Unilateral renal agenesis (HP:0000122)2.20515653
70Abnormality of the fingertips (HP:0001211)2.19945872
71Squamous cell carcinoma (HP:0002860)2.17860934
72Deformed sella turcica (HP:0002681)2.17716989
73Abnormality of fatty-acid metabolism (HP:0004359)2.17491239
74Dicarboxylic aciduria (HP:0003215)2.16751643
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16751643
76Papilloma (HP:0012740)2.16223987
77Verrucae (HP:0200043)2.16223987
78Abnormality of the thoracic spine (HP:0100711)2.15111037
79Recurrent bronchitis (HP:0002837)2.13154827
80Ventricular fibrillation (HP:0001663)2.10970906
81Pustule (HP:0200039)2.09878459
82Reticulocytosis (HP:0001923)2.09563596
83Abnormal delayed hypersensitivity skin test (HP:0002963)2.08813914
84Pterygium (HP:0001059)2.08657965
85Thin bony cortex (HP:0002753)2.08066393
86Thrombocytosis (HP:0001894)2.06168154
87Achilles tendon contracture (HP:0001771)2.04789353
88Atrophic scars (HP:0001075)2.04034228
89Increased IgE level (HP:0003212)2.02376872
90Abnormality of the distal phalanx of the thumb (HP:0009617)2.02162726
91Back pain (HP:0003418)2.01200607
92Spastic diplegia (HP:0001264)2.00396298
93Abnormality of carpal bone ossification (HP:0006257)2.00170871
94Colitis (HP:0002583)1.99602646
95Death in childhood (HP:0003819)1.98990827
96Abnormality of the Achilles tendon (HP:0005109)1.98912010
97Abnormality of the astrocytes (HP:0100707)1.98772001
98Astrocytoma (HP:0009592)1.98772001
99Oral leukoplakia (HP:0002745)1.98360173
100Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.98098422
101Absent epiphyses (HP:0010577)1.98098422
102Hand muscle atrophy (HP:0009130)1.97104964
103Thoracic kyphosis (HP:0002942)1.97080004
104Dysostosis multiplex (HP:0000943)1.96705870
105Abnormality of T cell physiology (HP:0011840)1.96635157
106Hypobetalipoproteinemia (HP:0003563)1.95556625
107Micronodular cirrhosis (HP:0001413)1.94827226
108Gastrointestinal inflammation (HP:0004386)1.94583645
109IgM deficiency (HP:0002850)1.94405235
110Bronchitis (HP:0012387)1.93693951
111Abnormality of endocrine pancreas physiology (HP:0012093)1.92863792
112Abnormality of the pancreatic islet cells (HP:0006476)1.92863792
113Hyperlipoproteinemia (HP:0010980)1.92306556
114Selective tooth agenesis (HP:0001592)1.91243955
115Abnormal protein glycosylation (HP:0012346)1.91085703
116Abnormal glycosylation (HP:0012345)1.91085703
117Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91085703
118Abnormal protein N-linked glycosylation (HP:0012347)1.91085703
119Atrioventricular block (HP:0001678)1.90700179
120Abnormal ossification of hand bones (HP:0005921)1.90586045
121Abnormality of pyrimidine metabolism (HP:0004353)1.89823275
122Nail dystrophy (HP:0008404)1.89570712
123Abnormality of T cells (HP:0002843)1.88992719
124Deep venous thrombosis (HP:0002625)1.88614911
125Deviation of the thumb (HP:0009603)1.87530632
126Hyperbilirubinemia (HP:0002904)1.86956270
127Pseudobulbar signs (HP:0002200)1.85357590
128Adenoma sebaceum (HP:0009720)1.85164974
129Angiofibromas (HP:0010615)1.85164974
130Abnormality of glutamine family amino acid metabolism (HP:0010902)1.84948787
131Sparse lateral eyebrow (HP:0005338)1.84943840
132* Long palpebral fissure (HP:0000637)1.84034362
133Vascular calcification (HP:0004934)1.83159292
134Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81928446
135Glioma (HP:0009733)1.81112565
136Mitral stenosis (HP:0001718)1.79715899
137Abnormality of aromatic amino acid family metabolism (HP:0004338)1.78636947
138Abnormality of the umbilical cord (HP:0010881)1.78392703
139Insomnia (HP:0100785)1.77862524
140Colon cancer (HP:0003003)1.76560951
141Abnormality of reticulocytes (HP:0004312)1.76398161
142Abnormality of nucleobase metabolism (HP:0010932)1.76289832
143Difficulty climbing stairs (HP:0003551)1.76148692
144Hyperinsulinemic hypoglycemia (HP:0000825)1.75931846
145Generalized aminoaciduria (HP:0002909)1.75796947
146Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.75040375
147Exercise-induced myalgia (HP:0003738)1.73944527
148Milia (HP:0001056)1.73827786
149Poikilocytosis (HP:0004447)1.72966191
150Impaired platelet aggregation (HP:0003540)1.72870409
151Abnormal platelet function (HP:0011869)1.72870409
152Heart block (HP:0012722)1.71885337
153Anteriorly placed anus (HP:0001545)1.71714943
154Heterotopia (HP:0002282)1.71679411
155Broad distal phalanx of finger (HP:0009836)1.71360511
156Malnutrition (HP:0004395)1.70651440
157Abnormality of purine metabolism (HP:0004352)1.69523110
158Proximal tubulopathy (HP:0000114)1.69372170
159Premature skin wrinkling (HP:0100678)1.68472107
160Inflammation of the large intestine (HP:0002037)1.68225686
161Neonatal death (HP:0003811)1.67980784
162Polycythemia (HP:0001901)1.67640783
163Abnormality of the acetabulum (HP:0003170)1.66072041
164Neonatal respiratory distress (HP:0002643)1.65926807
165Distal lower limb amyotrophy (HP:0008944)1.65113368
166Renovascular hypertension (HP:0100817)1.64961130
167Ventricular arrhythmia (HP:0004308)1.64846089
168Cafe-au-lait spot (HP:0000957)1.64832836
169Chronic bronchitis (HP:0004469)1.64502638
170Vaginal fistula (HP:0004320)1.63210727
171Abnormal number of erythroid precursors (HP:0012131)1.62852727
172Proximal placement of thumb (HP:0009623)1.62807034
173Syncope (HP:0001279)1.62430460
174Trismus (HP:0000211)1.61365973
175Loss of speech (HP:0002371)1.61244950
176Cholecystitis (HP:0001082)1.60671685
177Abnormal gallbladder physiology (HP:0012438)1.60671685
178Progressive hearing impairment (HP:0001730)1.60658072
179Abnormality of glycosphingolipid metabolism (HP:0004343)1.58815108
180Abnormality of glycolipid metabolism (HP:0010969)1.58815108
181Abnormality of liposaccharide metabolism (HP:0010968)1.58815108
182Fragile skin (HP:0001030)1.58110820
183Plantar hyperkeratosis (HP:0007556)1.57861314
184Fragile nails (HP:0001808)1.57800324
185Long toe (HP:0010511)1.56866525
186Glomerulosclerosis (HP:0000096)1.55339675
187Abnormality of oral frenula (HP:0000190)1.54982030
188Cardiovascular calcification (HP:0011915)1.54595929

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.71257481
2SMG13.57024818
3MAP4K13.19888479
4EEF2K3.19518614
5PKN23.18804322
6MST1R3.15526945
7ERN13.14955522
8MAP3K103.08773818
9BCKDK2.96126308
10NEK22.36644560
11CDK122.25614182
12ICK2.11999463
13PDK32.04967332
14PDK42.04967332
15MET2.00355781
16GRK61.89229476
17EPHB11.85790864
18PASK1.85383704
19LMTK21.84596434
20FGFR41.83441178
21PIM21.80098831
22NEK11.80006323
23SIK11.66808114
24STK101.65996427
25SCYL21.64910059
26RPS6KB21.56285768
27ALK1.52386523
28TTN1.45303483
29PTK61.45119808
30TTK1.38165695
31CDK41.35980400
32PRKD21.34146219
33ARAF1.30817257
34RIPK11.30424722
35CDK81.28857931
36MAPK151.27474783
37MTOR1.19277512
38STK381.16186290
39PRPF4B1.15546231
40CDC71.13424428
41BUB11.12965521
42TBK11.11573748
43VRK21.10040261
44PRKCH1.09578078
45PRKD31.08256745
46ZAP701.05095885
47MAP3K71.03546839
48CAMK1D1.03097286
49TYK21.02580736
50EPHA20.97587987
51MAP3K30.97073407
52IRAK20.96570380
53WEE10.95217573
54MAP3K80.94500219
55FLT30.94193729
56IRAK30.93691411
57CDK90.93403881
58TSSK60.92285709
59TESK20.89742925
60PTK20.89565553
61DYRK30.88662061
62TAOK10.86320250
63LRRK20.84723837
64ATR0.84353474
65FER0.81819319
66SIK20.80594629
67EPHA30.78746684
68ERBB40.78276494
69MELK0.78227182
70JAK10.76377189
71BRD40.76036547
72SIK30.75858971
73BMX0.75505852
74PRKCI0.74376823
75MAPKAPK30.74271395
76CDK60.74128134
77IRAK10.72462940
78CHEK10.72012195
79TESK10.71166383
80MAP3K90.71076834
81BTK0.70913942
82PDK20.70201979
83MAPK110.69409606
84RPS6KA20.68191969
85STK40.68078268
86PBK0.66422758
87AURKB0.64326846
88JAK20.62976306
89PDPK10.62390591
90DYRK1B0.62323266
91PIM10.61327362
92TAOK30.59929821
93MAP3K110.59565937
94CDC42BPA0.59459753
95MAP2K20.58879494
96CSNK1G30.58802718
97MAP2K30.58168136
98CDK70.57678350
99CAMK1G0.57420416
100AURKA0.57306127
101CSNK1A1L0.57274523
102KDR0.57226478
103PLK10.57189188
104CDK20.57039038
105ITK0.57006493
106MAP3K10.56479904
107PAK40.54826706
108PRKAA10.54277752
109MAP3K140.52987968
110JAK30.52729378
111TNK20.52649211
112FGFR30.49628465
113CHUK0.48048778
114MARK20.47472158
115MAP4K20.47109595
116TAOK20.46802205
117KSR20.46013229
118LATS10.45530824
119NEK90.45157641
120NME20.43728019
121AKT20.43713501
122HIPK20.43017602
123PDK10.41331982
124RPS6KA10.40895652
125DAPK10.39661064
126MAPKAPK20.39113023
127RPS6KA40.37719965
128IKBKB0.37368666
129FGFR10.37012696
130ATM0.36280886
131MAP2K60.36037083
132RET0.35720109
133CAMKK10.35455863
134PDGFRA0.35351919
135RPS6KA60.35184742
136CHEK20.35161732
137RPS6KL10.33967769
138RPS6KC10.33967769
139SYK0.30418593
140IRAK40.30096544
141PAK20.29331099
142CSNK1E0.28629728
143LIMK10.27381008
144NEK60.27042130
145MAP3K130.25186039

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.13215772
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.98829568
3Other glycan degradation_Homo sapiens_hsa005112.94987993
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.85127139
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.51077300
6Fatty acid degradation_Homo sapiens_hsa000712.32882947
7Selenocompound metabolism_Homo sapiens_hsa004502.21046783
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20398992
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.15130474
10One carbon pool by folate_Homo sapiens_hsa006702.12702019
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01895720
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.97268016
13Nitrogen metabolism_Homo sapiens_hsa009101.95072166
14Biosynthesis of amino acids_Homo sapiens_hsa012301.94947550
15DNA replication_Homo sapiens_hsa030301.90725633
16Carbon metabolism_Homo sapiens_hsa012001.90539936
17Lysine degradation_Homo sapiens_hsa003101.88633453
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.77357943
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.76214165
20Arginine biosynthesis_Homo sapiens_hsa002201.76198750
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75734596
22Propanoate metabolism_Homo sapiens_hsa006401.70134220
23Sulfur relay system_Homo sapiens_hsa041221.64446584
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61284887
25ABC transporters_Homo sapiens_hsa020101.60287699
26Tryptophan metabolism_Homo sapiens_hsa003801.58697190
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.57447949
28Lysosome_Homo sapiens_hsa041421.51565717
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49594079
30Fatty acid elongation_Homo sapiens_hsa000621.49586397
31Sphingolipid metabolism_Homo sapiens_hsa006001.48597869
32Fat digestion and absorption_Homo sapiens_hsa049751.47348239
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46797807
34Primary immunodeficiency_Homo sapiens_hsa053401.44733697
35Folate biosynthesis_Homo sapiens_hsa007901.42350378
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.42110581
37Pyruvate metabolism_Homo sapiens_hsa006201.41922238
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41557437
39Steroid biosynthesis_Homo sapiens_hsa001001.39392919
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.38173838
41Fatty acid metabolism_Homo sapiens_hsa012121.37893645
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.36351842
43RNA transport_Homo sapiens_hsa030131.35591621
44Base excision repair_Homo sapiens_hsa034101.30236813
45Fructose and mannose metabolism_Homo sapiens_hsa000511.28940155
46Bile secretion_Homo sapiens_hsa049761.24804178
47Pentose phosphate pathway_Homo sapiens_hsa000301.23894039
48Galactose metabolism_Homo sapiens_hsa000521.22586415
49Mismatch repair_Homo sapiens_hsa034301.18037949
50Insulin resistance_Homo sapiens_hsa049311.14342677
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13772331
52Phenylalanine metabolism_Homo sapiens_hsa003601.12075790
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11796138
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08349125
55Vibrio cholerae infection_Homo sapiens_hsa051101.08122045
56mRNA surveillance pathway_Homo sapiens_hsa030151.05218005
57Glycerolipid metabolism_Homo sapiens_hsa005611.03835675
58PPAR signaling pathway_Homo sapiens_hsa033201.01464726
59Glucagon signaling pathway_Homo sapiens_hsa049221.00013562
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98617117
61beta-Alanine metabolism_Homo sapiens_hsa004100.92735614
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91278175
63mTOR signaling pathway_Homo sapiens_hsa041500.91185248
64Spliceosome_Homo sapiens_hsa030400.90781602
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.89213685
66Starch and sucrose metabolism_Homo sapiens_hsa005000.87816789
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87742357
68Vitamin B6 metabolism_Homo sapiens_hsa007500.85515300
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85500201
70Glutathione metabolism_Homo sapiens_hsa004800.81834156
71p53 signaling pathway_Homo sapiens_hsa041150.81146768
72Acute myeloid leukemia_Homo sapiens_hsa052210.80860806
73Caffeine metabolism_Homo sapiens_hsa002320.78117550
74Peroxisome_Homo sapiens_hsa041460.75950703
75Histidine metabolism_Homo sapiens_hsa003400.74999189
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74353831
77Pyrimidine metabolism_Homo sapiens_hsa002400.74030089
78Insulin signaling pathway_Homo sapiens_hsa049100.73410687
79N-Glycan biosynthesis_Homo sapiens_hsa005100.73353228
80Butanoate metabolism_Homo sapiens_hsa006500.73289055
81Antigen processing and presentation_Homo sapiens_hsa046120.72426085
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71908654
83Fatty acid biosynthesis_Homo sapiens_hsa000610.71794339
84* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70769481
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70712749
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.70210113
87AMPK signaling pathway_Homo sapiens_hsa041520.69635387
88B cell receptor signaling pathway_Homo sapiens_hsa046620.69361122
89Notch signaling pathway_Homo sapiens_hsa043300.69354631
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69020258
91Pancreatic cancer_Homo sapiens_hsa052120.68145241
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67762838
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67355325
94Prostate cancer_Homo sapiens_hsa052150.67287874
95Hepatitis C_Homo sapiens_hsa051600.66137917
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64848409
97Sulfur metabolism_Homo sapiens_hsa009200.62611267
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61631293
99Apoptosis_Homo sapiens_hsa042100.59758911
100Cell cycle_Homo sapiens_hsa041100.58950474
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.57452070
102HTLV-I infection_Homo sapiens_hsa051660.54938444
103Arginine and proline metabolism_Homo sapiens_hsa003300.54493364
104Inositol phosphate metabolism_Homo sapiens_hsa005620.53952194
105Tyrosine metabolism_Homo sapiens_hsa003500.52886223
106Proteoglycans in cancer_Homo sapiens_hsa052050.52425189
107Chronic myeloid leukemia_Homo sapiens_hsa052200.52216230
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51311832
109T cell receptor signaling pathway_Homo sapiens_hsa046600.47093408
110Basal cell carcinoma_Homo sapiens_hsa052170.45550126
111Vitamin digestion and absorption_Homo sapiens_hsa049770.45319099
112ECM-receptor interaction_Homo sapiens_hsa045120.44966352
113MicroRNAs in cancer_Homo sapiens_hsa052060.44173137
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42095306
115Endometrial cancer_Homo sapiens_hsa052130.41201637
116Non-small cell lung cancer_Homo sapiens_hsa052230.40480059
117RNA degradation_Homo sapiens_hsa030180.39976982
118Small cell lung cancer_Homo sapiens_hsa052220.39549850
119Endocytosis_Homo sapiens_hsa041440.38397816
120* Metabolic pathways_Homo sapiens_hsa011000.38030029
121Thyroid hormone synthesis_Homo sapiens_hsa049180.37998130
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37615675
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37259418
124Pancreatic secretion_Homo sapiens_hsa049720.37084950
125Systemic lupus erythematosus_Homo sapiens_hsa053220.36717204
126Bladder cancer_Homo sapiens_hsa052190.35876708
127Hepatitis B_Homo sapiens_hsa051610.35298752
128Type II diabetes mellitus_Homo sapiens_hsa049300.33710414
129Focal adhesion_Homo sapiens_hsa045100.33484160
130Herpes simplex infection_Homo sapiens_hsa051680.33060474
131HIF-1 signaling pathway_Homo sapiens_hsa040660.32364748
132Alcoholism_Homo sapiens_hsa050340.30905140
133Viral carcinogenesis_Homo sapiens_hsa052030.27971023
134Thyroid cancer_Homo sapiens_hsa052160.25935417
135Homologous recombination_Homo sapiens_hsa034400.25693927
136Purine metabolism_Homo sapiens_hsa002300.23853530

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