PIGP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)7.86787432
2doxorubicin metabolic process (GO:0044598)7.86787432
3daunorubicin metabolic process (GO:0044597)7.86787432
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.68986888
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.42486712
6ATP synthesis coupled proton transport (GO:0015986)5.42486712
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.28070296
8aminoglycoside antibiotic metabolic process (GO:0030647)5.02193491
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.73373001
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.73373001
11NADH dehydrogenase complex assembly (GO:0010257)4.73373001
12protein complex biogenesis (GO:0070271)4.68068985
13electron transport chain (GO:0022900)4.67284323
14respiratory electron transport chain (GO:0022904)4.66214548
15cullin deneddylation (GO:0010388)4.62073439
16behavioral response to nicotine (GO:0035095)4.47929237
17protein deneddylation (GO:0000338)4.35337643
18regulation of cilium movement (GO:0003352)4.34009695
19ribosomal small subunit biogenesis (GO:0042274)4.27405133
20mitochondrial respiratory chain complex assembly (GO:0033108)4.25760376
21GTP biosynthetic process (GO:0006183)4.24090410
22chaperone-mediated protein transport (GO:0072321)4.22438588
23GDP-mannose metabolic process (GO:0019673)4.22249083
24cellular ketone body metabolic process (GO:0046950)4.21972519
25quinone metabolic process (GO:1901661)4.20420411
26guanosine-containing compound biosynthetic process (GO:1901070)4.11212368
27DNA deamination (GO:0045006)4.02160471
28cotranslational protein targeting to membrane (GO:0006613)3.98822638
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.98656313
30protein targeting to ER (GO:0045047)3.91159535
31rRNA methylation (GO:0031167)3.84200697
32respiratory chain complex IV assembly (GO:0008535)3.82105634
33ketone body metabolic process (GO:1902224)3.81842885
34rRNA modification (GO:0000154)3.81767405
35protein localization to endoplasmic reticulum (GO:0070972)3.81345783
36oxidative phosphorylation (GO:0006119)3.77617852
37piRNA metabolic process (GO:0034587)3.77085884
38establishment of protein localization to endoplasmic reticulum (GO:0072599)3.72012589
39water-soluble vitamin biosynthetic process (GO:0042364)3.67437302
40GPI anchor biosynthetic process (GO:0006506)3.66364584
41signal peptide processing (GO:0006465)3.62988987
42UTP biosynthetic process (GO:0006228)3.61214557
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.58942975
44termination of RNA polymerase III transcription (GO:0006386)3.58942975
45regulation of mitochondrial translation (GO:0070129)3.55000372
46viral transcription (GO:0019083)3.52180463
47indole-containing compound catabolic process (GO:0042436)3.50788191
48indolalkylamine catabolic process (GO:0046218)3.50788191
49tryptophan catabolic process (GO:0006569)3.50788191
50proteasome assembly (GO:0043248)3.50615180
51kynurenine metabolic process (GO:0070189)3.44314938
52protein localization to cilium (GO:0061512)3.37850539
53regulation of glucokinase activity (GO:0033131)3.37547024
54regulation of hexokinase activity (GO:1903299)3.37547024
55protein neddylation (GO:0045116)3.37499481
56translational termination (GO:0006415)3.36000662
57regulation of response to osmotic stress (GO:0047484)3.35973725
58L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.35892635
59detection of light stimulus involved in visual perception (GO:0050908)3.35789370
60detection of light stimulus involved in sensory perception (GO:0050962)3.35789370
61ribosomal small subunit assembly (GO:0000028)3.33970672
62indolalkylamine metabolic process (GO:0006586)3.31065504
63platelet dense granule organization (GO:0060155)3.30292843
64CTP metabolic process (GO:0046036)3.28976664
65CTP biosynthetic process (GO:0006241)3.28976664
66peptidyl-histidine modification (GO:0018202)3.25726710
67nucleoside diphosphate phosphorylation (GO:0006165)3.24326560
68translation (GO:0006412)3.23681333
69male meiosis I (GO:0007141)3.20590576
70UTP metabolic process (GO:0046051)3.19703907
71GPI anchor metabolic process (GO:0006505)3.19426556
72cytochrome complex assembly (GO:0017004)3.16399719
73protein polyglutamylation (GO:0018095)3.10999230
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10561580
75regulation of microtubule-based movement (GO:0060632)3.07791339
76purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.07742559
77DNA damage response, detection of DNA damage (GO:0042769)3.06897661
78L-fucose catabolic process (GO:0042355)3.06207266
79fucose catabolic process (GO:0019317)3.06207266
80L-fucose metabolic process (GO:0042354)3.06207266
81synapsis (GO:0007129)3.05422872
82intraciliary transport (GO:0042073)3.05306224
83aerobic respiration (GO:0009060)3.04787597
84axoneme assembly (GO:0035082)3.02441543
85purine nucleoside triphosphate biosynthetic process (GO:0009145)3.01887144
86cellular component biogenesis (GO:0044085)3.01500065
87inner mitochondrial membrane organization (GO:0007007)3.01102746
88mannosylation (GO:0097502)3.01016957
89protein targeting to mitochondrion (GO:0006626)2.98578136
90metallo-sulfur cluster assembly (GO:0031163)2.97324434
91iron-sulfur cluster assembly (GO:0016226)2.97324434
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.97153947
93inositol phosphate catabolic process (GO:0071545)2.97129255
94nonmotile primary cilium assembly (GO:0035058)2.95960045
95regulation of action potential (GO:0098900)2.94990407
96viral life cycle (GO:0019058)2.92614816
97tryptophan metabolic process (GO:0006568)2.92533931
98response to dietary excess (GO:0002021)2.91819250
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91365276
100pseudouridine synthesis (GO:0001522)2.90464963
101maintenance of protein location in nucleus (GO:0051457)2.90390497
102detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.90188134
103dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.90008310
104dopamine transport (GO:0015872)2.89855460
105RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89566074
106tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89566074
107pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.89208622
108establishment of protein localization to mitochondrial membrane (GO:0090151)2.89081918
109hydrogen ion transmembrane transport (GO:1902600)2.88925546
110central nervous system myelination (GO:0022010)2.88051123
111axon ensheathment in central nervous system (GO:0032291)2.88051123
112establishment of protein localization to mitochondrion (GO:0072655)2.87398097
113negative regulation of ligase activity (GO:0051352)2.86365658
114negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86365658
115translational elongation (GO:0006414)2.85310919
116DNA methylation involved in gamete generation (GO:0043046)2.84964718
117positive regulation of TOR signaling (GO:0032008)2.83832327
118proton transport (GO:0015992)2.83354627
1197-methylguanosine mRNA capping (GO:0006370)2.83290146
120DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83001052
121phosphorylated carbohydrate dephosphorylation (GO:0046838)2.81815171
122inositol phosphate dephosphorylation (GO:0046855)2.81815171
123exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80424724
124hydrogen transport (GO:0006818)2.79270506
125ribonucleoside triphosphate biosynthetic process (GO:0009201)2.78912807
126aromatic amino acid family catabolic process (GO:0009074)2.78783981
127negative regulation of epidermis development (GO:0045683)2.78489744
128epithelial cilium movement (GO:0003351)2.77518138
129response to pheromone (GO:0019236)2.76962274
130somite rostral/caudal axis specification (GO:0032525)2.76947138
131cytidine deamination (GO:0009972)2.75946126
132cytidine metabolic process (GO:0046087)2.75946126
133cytidine catabolic process (GO:0006216)2.75946126
1347-methylguanosine RNA capping (GO:0009452)2.75437531
135RNA capping (GO:0036260)2.75437531
136protein maturation by protein folding (GO:0022417)2.75330025
137intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75048016
138reciprocal DNA recombination (GO:0035825)2.74913102
139reciprocal meiotic recombination (GO:0007131)2.74913102
140anterograde synaptic vesicle transport (GO:0048490)2.72208060
141indole-containing compound metabolic process (GO:0042430)2.63267584
142nucleotide transmembrane transport (GO:1901679)2.60675316
143protein prenylation (GO:0018342)2.60070746
144prenylation (GO:0097354)2.60070746
145cellular biogenic amine catabolic process (GO:0042402)2.56610869
146amine catabolic process (GO:0009310)2.56610869
147cilium morphogenesis (GO:0060271)2.54234340
148positive regulation of meiosis (GO:0045836)2.51313845
149ATP biosynthetic process (GO:0006754)2.50304803
150oxidative demethylation (GO:0070989)2.50103786
151polyol catabolic process (GO:0046174)2.49931864
152male meiosis (GO:0007140)2.49691539
153L-methionine salvage (GO:0071267)2.48332645
154L-methionine biosynthetic process (GO:0071265)2.48332645
155amino acid salvage (GO:0043102)2.48332645
156* preassembly of GPI anchor in ER membrane (GO:0016254)2.47875391
157branched-chain amino acid catabolic process (GO:0009083)2.46684038
158regulation of meiosis I (GO:0060631)2.46577316
159cilium organization (GO:0044782)2.44966159
160protein-cofactor linkage (GO:0018065)2.44859326
161meiosis I (GO:0007127)2.44837850
162primary amino compound metabolic process (GO:1901160)2.42210531
163tRNA processing (GO:0008033)2.41575151
164neural tube formation (GO:0001841)2.41542489
165cilium assembly (GO:0042384)2.41312714
166ubiquinone biosynthetic process (GO:0006744)2.41304108
167photoreceptor cell maintenance (GO:0045494)2.41109374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.19375371
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.54042735
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.40919423
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.97201699
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.85097175
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.47048908
7CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.30671270
8ZNF274_21170338_ChIP-Seq_K562_Hela3.25196003
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.19559079
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.16971279
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16390397
12ELF1_17652178_ChIP-ChIP_JURKAT_Human3.16265759
13* PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.00881415
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.99286955
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.88531878
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.85077919
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.85077919
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.85077919
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77975872
20GBX2_23144817_ChIP-Seq_PC3_Human2.77806404
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.63666673
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50027917
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46225604
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43918214
25VDR_23849224_ChIP-Seq_CD4+_Human2.37486146
26FUS_26573619_Chip-Seq_HEK293_Human2.33906928
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32050406
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.30260444
29BP1_19119308_ChIP-ChIP_Hs578T_Human2.29178802
30EWS_26573619_Chip-Seq_HEK293_Human2.20166998
31FLI1_27457419_Chip-Seq_LIVER_Mouse2.19639912
32YY1_21170310_ChIP-Seq_MESCs_Mouse2.19161650
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16909987
34* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.16045797
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15328174
36MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14680458
37TAF15_26573619_Chip-Seq_HEK293_Human2.14264900
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13412601
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13137283
40THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10372472
41FOXP3_21729870_ChIP-Seq_TREG_Human2.09352113
42CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06140895
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94610321
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.91676332
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90755548
46P300_19829295_ChIP-Seq_ESCs_Human1.82841675
47EZH2_22144423_ChIP-Seq_EOC_Human1.80357556
48ER_23166858_ChIP-Seq_MCF-7_Human1.79944962
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.77724315
50GABP_19822575_ChIP-Seq_HepG2_Human1.76751104
51ELK1_19687146_ChIP-ChIP_HELA_Human1.73050273
52TP53_22573176_ChIP-Seq_HFKS_Human1.72211663
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68906499
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67522744
55XRN2_22483619_ChIP-Seq_HELA_Human1.66968439
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66109483
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64826467
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64180761
59DCP1A_22483619_ChIP-Seq_HELA_Human1.63502348
60IRF1_19129219_ChIP-ChIP_H3396_Human1.61130797
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58026482
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57282209
63BCAT_22108803_ChIP-Seq_LS180_Human1.55258016
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53413560
65MYC_18940864_ChIP-ChIP_HL60_Human1.49228235
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47801727
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46860711
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46174987
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.46174987
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45843721
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45196782
72SOX2_19829295_ChIP-Seq_ESCs_Human1.43549009
73NANOG_19829295_ChIP-Seq_ESCs_Human1.43549009
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43116064
75CBP_20019798_ChIP-Seq_JUKART_Human1.43116064
76TTF2_22483619_ChIP-Seq_HELA_Human1.42727650
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41034440
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40861926
79AR_25329375_ChIP-Seq_VCAP_Human1.40391125
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39618333
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.39503735
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36700425
83SMAD4_21799915_ChIP-Seq_A2780_Human1.35049506
84* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33114055
85* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33014503
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32313682
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32184349
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31588899
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.31198213
90STAT3_23295773_ChIP-Seq_U87_Human1.31114208
91* AR_20517297_ChIP-Seq_VCAP_Human1.30562744
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30168409
93NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.29851115
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.29415757
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28633876
96NCOR_22424771_ChIP-Seq_293T_Human1.28566588
97TCF4_23295773_ChIP-Seq_U87_Human1.28234123
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28213293
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27883388
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27747709
101TCF4_22108803_ChIP-Seq_LS180_Human1.27329478
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27180967
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.27132919
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27061496
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26892101
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26264103
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25154639
108SALL1_21062744_ChIP-ChIP_HESCs_Human1.24604422
109* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24225652
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23704918
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.23452748
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23439157
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22868688
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.22672842
115POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22553771
116BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21499628
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21385696
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20902563
119HTT_18923047_ChIP-ChIP_STHdh_Human1.20862062
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19617533
121GATA3_21878914_ChIP-Seq_MCF-7_Human1.19053007
122EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16420797
123VDR_22108803_ChIP-Seq_LS180_Human1.15881466
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15210446
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15155292
126NOTCH1_21737748_ChIP-Seq_TLL_Human1.13963717
127SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13486922
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11652537
129POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11431263
130PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10595433
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10156788
132AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09682115
133SMAD3_21741376_ChIP-Seq_EPCs_Human1.09222250
134SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08998103
135CRX_20693478_ChIP-Seq_RETINA_Mouse1.08961564
136RUNX2_22187159_ChIP-Seq_PCA_Human1.08665920
137CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08005072
138RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07534864
139REST_21632747_ChIP-Seq_MESCs_Mouse1.07006229
140CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05679507
141CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05082285
142HOXB7_26014856_ChIP-Seq_BT474_Human1.04622777
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03974079
144NANOG_18555785_Chip-Seq_ESCs_Mouse1.03825593
145FLI1_21867929_ChIP-Seq_TH2_Mouse1.03266147
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02580955
147POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02580955
148P53_22387025_ChIP-Seq_ESCs_Mouse1.02129132
149PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02110051
150SMAD4_21741376_ChIP-Seq_EPCs_Human1.01243960
151CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00400213
152KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00062489
153STAT3_18555785_Chip-Seq_ESCs_Mouse0.99744948
154YY1_22570637_ChIP-Seq_MALME-3M_Human0.99386305
155E2F1_17053090_ChIP-ChIP_MCF-7_Human0.98345758
156TP63_19390658_ChIP-ChIP_HaCaT_Human0.97961749
157TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97773793
158CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96038557
159RNF2_27304074_Chip-Seq_NSC_Mouse0.94736992
160IGF1R_20145208_ChIP-Seq_DFB_Human0.94609285
161MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93200412
162NANOG_16153702_ChIP-ChIP_HESCs_Human0.92602933
163NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92133842
164RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91358854
165PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90904657
166YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88992030
167TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86605705
168FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.86409525
169* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85739911
170SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85603170
171GATA1_22025678_ChIP-Seq_K562_Human0.83226492
172ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81545246
173* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81446343
174NANOG_18692474_ChIP-Seq_MEFs_Mouse0.80604228
175SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79762731
176SOX17_20123909_ChIP-Seq_XEN_Mouse0.78955411
177EOMES_21245162_ChIP-Seq_HESCs_Human0.78224815
178SOX2_16153702_ChIP-ChIP_HESCs_Human0.77849090
179NANOG_20526341_ChIP-Seq_ESCs_Human0.77699408
180GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77427112

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.96081416
2MP0008877_abnormal_DNA_methylation3.47581693
3MP0001986_abnormal_taste_sensitivity2.87439376
4MP0002653_abnormal_ependyma_morphology2.83845925
5MP0004043_abnormal_pH_regulation2.79921454
6MP0005075_abnormal_melanosome_morpholog2.76494377
7MP0006035_abnormal_mitochondrial_morpho2.72171832
8MP0003122_maternal_imprinting2.70218304
9MP0006036_abnormal_mitochondrial_physio2.69824482
10MP0000749_muscle_degeneration2.46057534
11MP0009046_muscle_twitch2.30266687
12MP0004145_abnormal_muscle_electrophysio2.25999692
13MP0005551_abnormal_eye_electrophysiolog2.20932310
14MP0001968_abnormal_touch/_nociception2.15425154
15MP0005379_endocrine/exocrine_gland_phen2.15004496
16MP0001905_abnormal_dopamine_level2.08390193
17MP0005394_taste/olfaction_phenotype2.06695994
18MP0005499_abnormal_olfactory_system2.06695994
19MP0001529_abnormal_vocalization2.05649433
20MP0006072_abnormal_retinal_apoptosis2.03867006
21MP0002102_abnormal_ear_morphology2.02600387
22MP0000678_abnormal_parathyroid_gland2.02186335
23MP0004147_increased_porphyrin_level2.00514061
24MP0000013_abnormal_adipose_tissue2.00472536
25MP0003787_abnormal_imprinting1.95760135
26MP0003183_abnormal_peptide_metabolism1.93428124
27MP0002638_abnormal_pupillary_reflex1.92694322
28MP0002736_abnormal_nociception_after1.89314496
29MP0003011_delayed_dark_adaptation1.89250207
30MP0002837_dystrophic_cardiac_calcinosis1.86612300
31MP0004133_heterotaxia1.81485786
32MP0008875_abnormal_xenobiotic_pharmacok1.78473735
33MP0000049_abnormal_middle_ear1.77062427
34MP0003880_abnormal_central_pattern1.76305361
35MP0008789_abnormal_olfactory_epithelium1.73560650
36MP0002938_white_spotting1.71955254
37MP0008872_abnormal_physiological_respon1.71798369
38MP0000372_irregular_coat_pigmentation1.70534295
39MP0000569_abnormal_digit_pigmentation1.70273069
40MP0000631_abnormal_neuroendocrine_gland1.68127867
41MP0002751_abnormal_autonomic_nervous1.65833636
42MP0004142_abnormal_muscle_tone1.64696005
43MP0002332_abnormal_exercise_endurance1.57877654
44MP0003186_abnormal_redox_activity1.56032321
45MP0004957_abnormal_blastocyst_morpholog1.55075651
46MP0010386_abnormal_urinary_bladder1.53988736
47MP0002163_abnormal_gland_morphology1.53341817
48MP0009745_abnormal_behavioral_response1.53030448
49MP0003806_abnormal_nucleotide_metabolis1.47905975
50MP0008058_abnormal_DNA_repair1.43395808
51MP0004264_abnormal_extraembryonic_tissu1.43083387
52MP0005646_abnormal_pituitary_gland1.38866904
53MP0005174_abnormal_tail_pigmentation1.38586901
54MP0003718_maternal_effect1.36138789
55MP0005084_abnormal_gallbladder_morpholo1.35976014
56MP0009379_abnormal_foot_pigmentation1.35837932
57MP0004270_analgesia1.34468344
58MP0003137_abnormal_impulse_conducting1.31791597
59MP0003136_yellow_coat_color1.30419096
60MP0010030_abnormal_orbit_morphology1.30184675
61MP0000427_abnormal_hair_cycle1.29876827
62MP0005332_abnormal_amino_acid1.29154176
63MP0001348_abnormal_lacrimal_gland1.28975353
64MP0001501_abnormal_sleep_pattern1.28810404
65MP0002127_abnormal_cardiovascular_syste1.27111168
66MP0006276_abnormal_autonomic_nervous1.25238658
67MP0002160_abnormal_reproductive_system1.25234886
68MP0000762_abnormal_tongue_morphology1.23651054
69MP0002928_abnormal_bile_duct1.22624712
70MP0003121_genomic_imprinting1.22130794
71MP0002909_abnormal_adrenal_gland1.22117174
72MP0001188_hyperpigmentation1.20162491
73MP0005253_abnormal_eye_physiology1.19123588
74MP0004885_abnormal_endolymph1.18375253
75MP0003315_abnormal_perineum_morphology1.17368245
76MP0008995_early_reproductive_senescence1.16967848
77MP0005410_abnormal_fertilization1.16362982
78MP0001764_abnormal_homeostasis1.15621846
79MP0005645_abnormal_hypothalamus_physiol1.14190511
80MP0002693_abnormal_pancreas_physiology1.14145017
81MP0001970_abnormal_pain_threshold1.13639500
82MP0001486_abnormal_startle_reflex1.13327491
83MP0005085_abnormal_gallbladder_physiolo1.13297539
84MP0003195_calcinosis1.09668157
85MP0003252_abnormal_bile_duct1.08211240
86MP0004381_abnormal_hair_follicle1.06974445
87MP0002064_seizures1.06837347
88MP0005389_reproductive_system_phenotype1.06410431
89MP0002735_abnormal_chemical_nociception1.06315338
90MP0001485_abnormal_pinna_reflex1.05712929
91MP0002557_abnormal_social/conspecific_i1.04125193
92MP0003938_abnormal_ear_development1.04002288
93MP0005367_renal/urinary_system_phenotyp1.03713757
94MP0000516_abnormal_urinary_system1.03713757
95MP0002572_abnormal_emotion/affect_behav1.03394055
96MP0008932_abnormal_embryonic_tissue1.02253928
97MP0001944_abnormal_pancreas_morphology1.02123731
98MP0009697_abnormal_copulation1.01888516
99MP0002106_abnormal_muscle_physiology1.01381806
100MP0005386_behavior/neurological_phenoty1.00916160
101MP0004924_abnormal_behavior1.00916160
102MP0005266_abnormal_metabolism1.00262602
103MP0004036_abnormal_muscle_relaxation0.99081168
104MP0003646_muscle_fatigue0.99064126
105MP0002233_abnormal_nose_morphology0.98385359
106MP0005423_abnormal_somatic_nervous0.98274022
107MP0002277_abnormal_respiratory_mucosa0.96432367
108MP0002234_abnormal_pharynx_morphology0.96318737
109MP0002210_abnormal_sex_determination0.95889455
110MP0001756_abnormal_urination0.95138507
111MP0005369_muscle_phenotype0.94423176
112MP0004215_abnormal_myocardial_fiber0.94075433
113MP0002067_abnormal_sensory_capabilities0.93779691
114MP0005365_abnormal_bile_salt0.91148813
115MP0000538_abnormal_urinary_bladder0.90705183
116MP0001929_abnormal_gametogenesis0.88972190
117MP0004085_abnormal_heartbeat0.88809424
118MP0004742_abnormal_vestibular_system0.88578077
119MP0003698_abnormal_male_reproductive0.87950609
120MP0010329_abnormal_lipoprotein_level0.87523451
121MP0001270_distended_abdomen0.86763197
122MP0000230_abnormal_systemic_arterial0.86184493
123MP0005448_abnormal_energy_balance0.84912043
124MP0001324_abnormal_eye_pigmentation0.84740652
125MP0003786_premature_aging0.84658228
126MP0002752_abnormal_somatic_nervous0.83846258
127MP0005083_abnormal_biliary_tract0.83676350
128MP0000750_abnormal_muscle_regeneration0.81903090
129MP0005330_cardiomyopathy0.81627103
130MP0002272_abnormal_nervous_system0.81330122
131MP0002877_abnormal_melanocyte_morpholog0.80949758
132MP0005636_abnormal_mineral_homeostasis0.80396686
133MP0001984_abnormal_olfaction0.80233141
134MP0001963_abnormal_hearing_physiology0.80133737
135MP0002269_muscular_atrophy0.80021215
136MP0003283_abnormal_digestive_organ0.78526978
137MP0000358_abnormal_cell_content/0.78519578
138MP0000613_abnormal_salivary_gland0.78436361
139MP0000026_abnormal_inner_ear0.77117214
140MP0002734_abnormal_mechanical_nocicepti0.75614758
141MP0003693_abnormal_embryo_hatching0.74547818
142MP0002932_abnormal_joint_morphology0.72997442
143MP0002114_abnormal_axial_skeleton0.70769346
144MP0002249_abnormal_larynx_morphology0.68964607
145MP0001293_anophthalmia0.68454415
146MP0005391_vision/eye_phenotype0.68385439
147MP0003890_abnormal_embryonic-extraembry0.67694777
148MP0005220_abnormal_exocrine_pancreas0.67423893
149MP0003123_paternal_imprinting0.63815537
150MP0000759_abnormal_skeletal_muscle0.63183943
151MP0002078_abnormal_glucose_homeostasis0.60995848
152MP0002733_abnormal_thermal_nociception0.60087748
153MP0002876_abnormal_thyroid_physiology0.59985593
154MP0004134_abnormal_chest_morphology0.59762661

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.20572479
2Abnormal mitochondria in muscle tissue (HP:0008316)4.76343454
3Mitochondrial inheritance (HP:0001427)4.33547386
43-Methylglutaconic aciduria (HP:0003535)4.28710509
5Hepatocellular necrosis (HP:0001404)4.21965885
6Hepatic necrosis (HP:0002605)4.15430850
7Acute encephalopathy (HP:0006846)4.13140515
8Progressive macrocephaly (HP:0004481)4.05945886
9Type I transferrin isoform profile (HP:0003642)3.88092331
10Increased CSF lactate (HP:0002490)3.82735942
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.47337475
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.47337475
13Hypothermia (HP:0002045)3.23482315
14Congenital stationary night blindness (HP:0007642)3.22674439
15Reduced antithrombin III activity (HP:0001976)3.19863956
16Hyperinsulinemic hypoglycemia (HP:0000825)3.19570304
17Nephronophthisis (HP:0000090)3.15487817
18Abnormality of the renal cortex (HP:0011035)3.13167241
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.12370196
20Exercise intolerance (HP:0003546)3.11706571
21Renal Fanconi syndrome (HP:0001994)3.10408217
22Abnormal protein N-linked glycosylation (HP:0012347)3.08742671
23Abnormal protein glycosylation (HP:0012346)3.08742671
24Abnormal glycosylation (HP:0012345)3.08742671
25Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.08742671
26Bilateral microphthalmos (HP:0007633)2.99367893
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.92797385
28Abnormality of glycolysis (HP:0004366)2.87143558
29Increased serum pyruvate (HP:0003542)2.87143558
30Abnormality of cells of the erythroid lineage (HP:0012130)2.84730069
31Microvesicular hepatic steatosis (HP:0001414)2.83764371
32Increased hepatocellular lipid droplets (HP:0006565)2.82350443
33Abnormality of the renal medulla (HP:0100957)2.76044520
34Renal cortical cysts (HP:0000803)2.74864728
35Increased serum lactate (HP:0002151)2.72548454
36Ketoacidosis (HP:0001993)2.69493139
37Attenuation of retinal blood vessels (HP:0007843)2.69375346
38Lactic acidosis (HP:0003128)2.69247078
39Bifid tongue (HP:0010297)2.68210209
40Lipid accumulation in hepatocytes (HP:0006561)2.64880232
41Abnormal number of erythroid precursors (HP:0012131)2.63211795
42Leukodystrophy (HP:0002415)2.62992361
43Abnormality of alanine metabolism (HP:0010916)2.58540588
44Hyperalaninemia (HP:0003348)2.58540588
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58540588
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55269719
47Methylmalonic acidemia (HP:0002912)2.55258195
48Methylmalonic aciduria (HP:0012120)2.53038172
49Cerebral edema (HP:0002181)2.52834403
50Type II lissencephaly (HP:0007260)2.52773425
51Progressive muscle weakness (HP:0003323)2.52655008
52Multiple enchondromatosis (HP:0005701)2.49359652
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.48828060
54Hypoplasia of the fovea (HP:0007750)2.48828060
55Respiratory failure (HP:0002878)2.48668001
56Abnormality of the fovea (HP:0000493)2.48360371
57Increased intramyocellular lipid droplets (HP:0012240)2.45821085
58Gaze-evoked nystagmus (HP:0000640)2.37991122
59Generalized aminoaciduria (HP:0002909)2.36028708
60Rib fusion (HP:0000902)2.35398429
61Hyperventilation (HP:0002883)2.35099012
62Abolished electroretinogram (ERG) (HP:0000550)2.31115511
63Ketosis (HP:0001946)2.29863771
64Chronic hepatic failure (HP:0100626)2.29019451
65Congenital, generalized hypertrichosis (HP:0004540)2.27070621
66Optic disc pallor (HP:0000543)2.26686352
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.22171404
68Tubular atrophy (HP:0000092)2.21707131
69Abnormal ciliary motility (HP:0012262)2.19089242
70Male pseudohermaphroditism (HP:0000037)2.18448053
71Abnormal rod and cone electroretinograms (HP:0008323)2.18420899
72Increased muscle lipid content (HP:0009058)2.18081711
73Aplastic anemia (HP:0001915)2.17956296
74Abnormality of midbrain morphology (HP:0002418)2.17624929
75Molar tooth sign on MRI (HP:0002419)2.17624929
76Aplasia/hypoplasia of the uterus (HP:0008684)2.17437252
77Abnormal drinking behavior (HP:0030082)2.17358611
78Polydipsia (HP:0001959)2.17358611
79Cerebral hypomyelination (HP:0006808)2.15022288
80Medial flaring of the eyebrow (HP:0010747)2.14960799
81Aplasia/Hypoplasia of the tibia (HP:0005772)2.14459390
82Cystic liver disease (HP:0006706)2.12100615
83Emotional lability (HP:0000712)2.11888876
84True hermaphroditism (HP:0010459)2.08321527
85Abnormality of renal resorption (HP:0011038)2.06668403
86Bony spicule pigmentary retinopathy (HP:0007737)2.06037051
87Furrowed tongue (HP:0000221)2.03968232
88Abnormal respiratory motile cilium physiology (HP:0012261)2.03805561
89Nonprogressive disorder (HP:0003680)2.03432888
90Partial duplication of thumb phalanx (HP:0009944)2.01847038
91Pancreatic fibrosis (HP:0100732)2.01148429
92Dynein arm defect of respiratory motile cilia (HP:0012255)2.00295738
93Absent/shortened dynein arms (HP:0200106)2.00295738
94Rhinitis (HP:0012384)2.00202490
95Type 2 muscle fiber atrophy (HP:0003554)1.99386493
96Abnormality of the heme biosynthetic pathway (HP:0010472)1.98790304
97Sclerocornea (HP:0000647)1.98315179
98Inability to walk (HP:0002540)1.97837198
99Neuroendocrine neoplasm (HP:0100634)1.97393108
100Muscle fiber atrophy (HP:0100295)1.97212790
101Chronic bronchitis (HP:0004469)1.96577815
102Constricted visual fields (HP:0001133)1.95977940
103Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94719290
104Ragged-red muscle fibers (HP:0003200)1.94238864
105Hypomagnesemia (HP:0002917)1.92639858
106Genital tract atresia (HP:0001827)1.90795005
107Hypoglycemic coma (HP:0001325)1.90062774
108Spastic paraparesis (HP:0002313)1.90003519
109Symptomatic seizures (HP:0011145)1.89925620
110Pancreatic cysts (HP:0001737)1.89179310
111Nasolacrimal duct obstruction (HP:0000579)1.88147655
112Abnormality of vitamin B metabolism (HP:0004340)1.87550965
113Congenital hepatic fibrosis (HP:0002612)1.87316703
114Progressive cerebellar ataxia (HP:0002073)1.87308156
115Congenital primary aphakia (HP:0007707)1.85916879
116Rectovaginal fistula (HP:0000143)1.85546255
117Rectal fistula (HP:0100590)1.85546255
118Decreased central vision (HP:0007663)1.85212119
119Short tibia (HP:0005736)1.84298787
120Abnormal biliary tract physiology (HP:0012439)1.83867690
121Bile duct proliferation (HP:0001408)1.83867690
122Large for gestational age (HP:0001520)1.83353895
123Progressive microcephaly (HP:0000253)1.82829891
124Abnormal pupillary function (HP:0007686)1.82390259
125Supernumerary spleens (HP:0009799)1.82379180
126Exercise-induced muscle cramps (HP:0003710)1.81876759
127Abnormal albumin level (HP:0012116)1.81800209
128Hypoalbuminemia (HP:0003073)1.81800209
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.81221194
130Dicarboxylic aciduria (HP:0003215)1.81047843
131Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81047843
132Polyuria (HP:0000103)1.80602918
133X-linked dominant inheritance (HP:0001423)1.80029233
134Vaginal atresia (HP:0000148)1.80013366
135Gait imbalance (HP:0002141)1.80004385
136Abnormal respiratory epithelium morphology (HP:0012253)1.79185782
137Abnormal respiratory motile cilium morphology (HP:0005938)1.79185782
138Febrile seizures (HP:0002373)1.77085867
139Exertional dyspnea (HP:0002875)1.76933238
140Severe muscular hypotonia (HP:0006829)1.76928219
141Vaginal fistula (HP:0004320)1.76272320
142Nephrogenic diabetes insipidus (HP:0009806)1.75021385
143Retinal dysplasia (HP:0007973)1.73985573
144Glycosuria (HP:0003076)1.72658499
145Abnormality of urine glucose concentration (HP:0011016)1.72658499
146Microretrognathia (HP:0000308)1.70609229
147Abnormal lung lobation (HP:0002101)1.69125494
148Hypoglycemic seizures (HP:0002173)1.68892521
149Hypoplasia of the uterus (HP:0000013)1.67881171
150Anencephaly (HP:0002323)1.66992682
151Lethargy (HP:0001254)1.65447055
152Sparse eyelashes (HP:0000653)1.65246388
153Abnormality of aromatic amino acid family metabolism (HP:0004338)1.64281261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.97254863
2NME13.51919871
3MAPK153.43425024
4ADRBK23.32086732
5STK163.22027789
6GRK52.92122642
7MAP4K22.90042842
8ARAF2.70328085
9BUB12.62551278
10MUSK2.47219760
11NUAK12.31491504
12GRK12.16406313
13ZAK2.13726997
14IRAK22.08901072
15TNIK2.00589253
16NME21.99877407
17WEE11.97289588
18VRK11.95002838
19MST41.84634058
20BRSK21.81033350
21TRIM281.80764617
22DYRK31.78432753
23CDK191.77532133
24GRK71.71169700
25PINK11.66532311
26OBSCN1.66451293
27DYRK21.62833876
28WNK41.62687187
29HIPK21.55383001
30MAP3K41.50782197
31TAOK31.50686792
32PIM21.50395415
33BCKDK1.47686563
34FLT31.44548527
35BRAF1.43662040
36AKT31.41311710
37MOS1.39483628
38WNK31.37850200
39MAPK131.35264267
40SRPK11.28044926
41STK391.27232355
42PASK1.26018772
43ERN11.23748078
44CSF1R1.22043937
45PRKG21.20089231
46DAPK21.19224084
47STK38L1.18110162
48PNCK1.17420629
49GRK61.16187994
50VRK21.12265043
51BCR1.08850756
52PIK3CG1.07778641
53MATK1.05787699
54MAP3K121.03875758
55NTRK31.03438903
56WNK11.02351489
57TGFBR21.01436558
58PRKCE1.01405298
59PRKCG1.01241739
60TXK1.00698242
61ACVR1B1.00287790
62OXSR10.99103388
63PLK20.96784326
64MKNK20.95058164
65MYLK0.94087712
66CSNK1G30.93191507
67PHKG20.92869609
68PHKG10.92869609
69CDK80.92485821
70NTRK10.91055184
71INSRR0.87324663
72CSNK1A1L0.87242130
73ADRBK10.87006163
74MAP2K60.86000658
75PTK2B0.85013724
76EIF2AK30.82457097
77MAP2K70.81698996
78LIMK10.80574853
79NEK10.80094973
80UHMK10.79342911
81ERBB30.78604926
82CASK0.74703568
83CCNB10.74635925
84TIE10.73278024
85TGFBR10.72378950
86PDK20.72027026
87EPHA20.71969144
88PRKCI0.71187413
89TNK20.70471849
90TAF10.69842225
91TEC0.68479439
92MAPKAPK50.68146624
93MAPK70.67549530
94BMPR1B0.64081925
95RPS6KA50.63781705
96AURKA0.63136080
97IRAK10.61663821
98STK30.61214695
99CAMK2G0.58911492
100IKBKB0.58614639
101CDK120.57936839
102CAMKK20.56308657
103CAMK2A0.54129872
104KIT0.53806642
105PLK30.53519570
106CSNK1A10.52782467
107CHEK20.52372218
108PRKACA0.51707900
109ILK0.50733563
110CDK70.50084580
111CAMK10.49806869
112PIK3CA0.48542617
113CAMK2B0.48534779
114CSNK1G10.48488618
115PLK40.48295233
116PLK10.48065545
117CAMK2D0.47707729
118RPS6KB20.47607980
119DAPK10.47555892
120FGFR20.46145578
121MKNK10.45327662
122EPHA30.44897121
123TLK10.44894649
124BMPR20.43846895
125MAPKAPK30.43206333
126STK240.42492142
127CAMK1G0.41897696
128PRKG10.39734022
129PRKAA20.39488150
130FER0.39469921
131PRKCA0.38911596
132DYRK1A0.38494355
133CSNK1G20.38189529
134MAP3K30.37596708
135PRKCQ0.36450707
136ITK0.36183920
137NLK0.35797869
138PAK30.35768268
139NEK60.35585671
140BRSK10.34468933
141CDK30.34375454
142SIK30.34103813
143EIF2AK10.33898842
144PKN10.33832718
145CSNK2A10.33576142
146DYRK1B0.32455892
147EIF2AK20.30677320

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.55686241
2Oxidative phosphorylation_Homo sapiens_hsa001904.46498150
3Ribosome_Homo sapiens_hsa030104.18159122
4Parkinsons disease_Homo sapiens_hsa050123.92578642
5Proteasome_Homo sapiens_hsa030503.26017453
6RNA polymerase_Homo sapiens_hsa030202.99002863
7Huntingtons disease_Homo sapiens_hsa050162.86026515
8Alzheimers disease_Homo sapiens_hsa050102.81452847
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.66749050
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.36694914
11Sulfur metabolism_Homo sapiens_hsa009202.19777463
12Folate biosynthesis_Homo sapiens_hsa007902.18891861
13Nitrogen metabolism_Homo sapiens_hsa009101.89460126
14Pyrimidine metabolism_Homo sapiens_hsa002401.83992858
15Cardiac muscle contraction_Homo sapiens_hsa042601.75966595
16Linoleic acid metabolism_Homo sapiens_hsa005911.73691108
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73207340
18Tryptophan metabolism_Homo sapiens_hsa003801.70461900
19Arachidonic acid metabolism_Homo sapiens_hsa005901.70252834
20Regulation of autophagy_Homo sapiens_hsa041401.65286662
21* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63579705
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60404809
23Vitamin B6 metabolism_Homo sapiens_hsa007501.58408281
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56821451
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53717995
26Basal transcription factors_Homo sapiens_hsa030221.53558921
27Mismatch repair_Homo sapiens_hsa034301.51610343
28DNA replication_Homo sapiens_hsa030301.44512546
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42980702
30Fatty acid elongation_Homo sapiens_hsa000621.42166182
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40376216
32Caffeine metabolism_Homo sapiens_hsa002321.33644491
33Purine metabolism_Homo sapiens_hsa002301.32855683
34Nicotine addiction_Homo sapiens_hsa050331.29398076
35Spliceosome_Homo sapiens_hsa030401.26771424
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26286446
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25084113
38Nucleotide excision repair_Homo sapiens_hsa034201.23632739
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23304208
40RNA degradation_Homo sapiens_hsa030181.18314547
41Galactose metabolism_Homo sapiens_hsa000521.16573072
42beta-Alanine metabolism_Homo sapiens_hsa004101.15913093
43Ether lipid metabolism_Homo sapiens_hsa005651.14060375
44Retinol metabolism_Homo sapiens_hsa008301.12215700
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.12105161
46Vibrio cholerae infection_Homo sapiens_hsa051101.06033353
47Homologous recombination_Homo sapiens_hsa034401.04704135
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.03653652
49One carbon pool by folate_Homo sapiens_hsa006701.03455959
50Fructose and mannose metabolism_Homo sapiens_hsa000511.01484406
51Base excision repair_Homo sapiens_hsa034100.98482322
52Sulfur relay system_Homo sapiens_hsa041220.97973134
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95414407
54* Metabolic pathways_Homo sapiens_hsa011000.93390496
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91185357
56Olfactory transduction_Homo sapiens_hsa047400.90543194
57N-Glycan biosynthesis_Homo sapiens_hsa005100.86335156
58Other glycan degradation_Homo sapiens_hsa005110.84053237
59Type I diabetes mellitus_Homo sapiens_hsa049400.83864072
60Fatty acid degradation_Homo sapiens_hsa000710.82525942
61RNA transport_Homo sapiens_hsa030130.82462062
62Collecting duct acid secretion_Homo sapiens_hsa049660.82182866
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.81025656
64Morphine addiction_Homo sapiens_hsa050320.79036090
65Circadian rhythm_Homo sapiens_hsa047100.78055087
66ABC transporters_Homo sapiens_hsa020100.77941433
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77057374
68Sphingolipid metabolism_Homo sapiens_hsa006000.76672622
69Asthma_Homo sapiens_hsa053100.76142210
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75132169
71Glutathione metabolism_Homo sapiens_hsa004800.67042057
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65287204
73Circadian entrainment_Homo sapiens_hsa047130.62881584
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61943861
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61790388
76Fatty acid metabolism_Homo sapiens_hsa012120.61327645
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60784164
78Taste transduction_Homo sapiens_hsa047420.60697841
79Non-homologous end-joining_Homo sapiens_hsa034500.58417420
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56370017
81Serotonergic synapse_Homo sapiens_hsa047260.56066350
82Fanconi anemia pathway_Homo sapiens_hsa034600.55552241
83Histidine metabolism_Homo sapiens_hsa003400.55146635
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54822293
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54574631
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51827972
87Glycerolipid metabolism_Homo sapiens_hsa005610.49919919
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49290646
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49184662
90Propanoate metabolism_Homo sapiens_hsa006400.48956704
91Mineral absorption_Homo sapiens_hsa049780.48170649
92Glutamatergic synapse_Homo sapiens_hsa047240.45219319
93Fat digestion and absorption_Homo sapiens_hsa049750.43752558
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41959789
95Cell cycle_Homo sapiens_hsa041100.40918238
96Calcium signaling pathway_Homo sapiens_hsa040200.39250216
97Chemical carcinogenesis_Homo sapiens_hsa052040.38218411
98Pyruvate metabolism_Homo sapiens_hsa006200.35768498
99Arginine and proline metabolism_Homo sapiens_hsa003300.35609389
100Thyroid cancer_Homo sapiens_hsa052160.35379290
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35096331
102Peroxisome_Homo sapiens_hsa041460.34660247
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31675314
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31392192
105Steroid biosynthesis_Homo sapiens_hsa001000.30892620
106Insulin secretion_Homo sapiens_hsa049110.30891634
107Ovarian steroidogenesis_Homo sapiens_hsa049130.29060022
108Tyrosine metabolism_Homo sapiens_hsa003500.27360417
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26107095
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25804542
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24420562
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24210430
113Carbon metabolism_Homo sapiens_hsa012000.22516643
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21927027
115Alcoholism_Homo sapiens_hsa050340.21268955
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.20863317
117Lysosome_Homo sapiens_hsa041420.17819207
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.16617717
119Selenocompound metabolism_Homo sapiens_hsa004500.16473973
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15575711
121Hedgehog signaling pathway_Homo sapiens_hsa043400.13126504
122Rheumatoid arthritis_Homo sapiens_hsa053230.13088703
123Pentose phosphate pathway_Homo sapiens_hsa000300.12958433
124Butanoate metabolism_Homo sapiens_hsa006500.12666372
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.12157322
126GABAergic synapse_Homo sapiens_hsa047270.08967654
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08840771
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.08451881
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.06445795
130Phototransduction_Homo sapiens_hsa047440.05857103
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.03914184
132Epstein-Barr virus infection_Homo sapiens_hsa051690.01724200

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