PIGQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1porphyrin-containing compound biosynthetic process (GO:0006779)9.21059386
2heme biosynthetic process (GO:0006783)9.14303982
3tetrapyrrole biosynthetic process (GO:0033014)8.21199231
4response to methylmercury (GO:0051597)7.84927698
5porphyrin-containing compound metabolic process (GO:0006778)7.18493031
6heme metabolic process (GO:0042168)7.06743723
7response to lead ion (GO:0010288)6.30273787
8oxygen transport (GO:0015671)5.94324216
9erythrocyte maturation (GO:0043249)5.69728946
10hemoglobin metabolic process (GO:0020027)5.65491153
11negative regulation of erythrocyte differentiation (GO:0045647)5.06208586
12tetrapyrrole metabolic process (GO:0033013)4.93914121
13lysine catabolic process (GO:0006554)4.75954532
14lysine metabolic process (GO:0006553)4.75954532
15erythrocyte development (GO:0048821)4.65405076
16response to insecticide (GO:0017085)4.64172225
17cytoskeletal anchoring at plasma membrane (GO:0007016)4.54697054
18axon ensheathment in central nervous system (GO:0032291)4.47777057
19central nervous system myelination (GO:0022010)4.47777057
20intracellular estrogen receptor signaling pathway (GO:0030520)4.47386861
21regulation of response to osmotic stress (GO:0047484)4.46737760
22mannose metabolic process (GO:0006013)4.22957041
23aspartate family amino acid catabolic process (GO:0009068)4.20804699
24semaphorin-plexin signaling pathway (GO:0071526)4.15377714
25one-carbon compound transport (GO:0019755)4.06301809
26bicarbonate transport (GO:0015701)3.89882103
27protein retention in ER lumen (GO:0006621)3.86894848
28planar cell polarity pathway involved in neural tube closure (GO:0090179)3.82567806
29glycine transport (GO:0015816)3.75962935
30pigment biosynthetic process (GO:0046148)3.75192331
31heme transport (GO:0015886)3.73036006
32sodium ion export (GO:0071436)3.72676399
33negative regulation of cell size (GO:0045792)3.67037920
34drug transmembrane transport (GO:0006855)3.54260743
35response to mercury ion (GO:0046689)3.53504335
36regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.46466368
37retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.45308183
38cysteine metabolic process (GO:0006534)3.44935278
39L-alpha-amino acid transmembrane transport (GO:1902475)3.43514650
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.39512600
41glutathione biosynthetic process (GO:0006750)3.37045505
42GDP-mannose metabolic process (GO:0019673)3.36193416
43cell migration in hindbrain (GO:0021535)3.35563779
44myeloid cell development (GO:0061515)3.33288886
45phosphate ion transport (GO:0006817)3.32409276
46positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.32390137
47iron coordination entity transport (GO:1901678)3.30808604
48cellular potassium ion homeostasis (GO:0030007)3.30086122
49peptidyl-cysteine modification (GO:0018198)3.28773416
50synaptic vesicle maturation (GO:0016188)3.26196816
51proline biosynthetic process (GO:0006561)3.25419096
52nonribosomal peptide biosynthetic process (GO:0019184)3.23444928
53gas transport (GO:0015669)3.21306675
54myelin maintenance (GO:0043217)3.20767105
55pigment metabolic process (GO:0042440)3.19171026
56motile cilium assembly (GO:0044458)3.19137859
57UV protection (GO:0009650)3.18801415
58actin filament capping (GO:0051693)3.18133095
59cell-cell junction maintenance (GO:0045217)3.17726528
60erythrocyte differentiation (GO:0030218)3.16911383
61fatty acid elongation (GO:0030497)3.15167678
62positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.13149470
63regulation of mammary gland epithelial cell proliferation (GO:0033599)3.11565764
64peptidyl-tyrosine autophosphorylation (GO:0038083)3.08750502
65cell volume homeostasis (GO:0006884)3.08101756
66cofactor biosynthetic process (GO:0051188)3.07405742
67positive regulation of synapse maturation (GO:0090129)3.05138792
68creatine metabolic process (GO:0006600)3.04265464
69establishment of apical/basal cell polarity (GO:0035089)3.04246860
70regulation of cholesterol biosynthetic process (GO:0045540)3.01183435
71short-chain fatty acid metabolic process (GO:0046459)2.98634270
72apoptotic process involved in morphogenesis (GO:0060561)2.97639396
73import into cell (GO:0098657)2.97210015
74regulation of hydrogen peroxide metabolic process (GO:0010310)2.94303332
75histone H4 deacetylation (GO:0070933)2.92367822
76potassium ion import (GO:0010107)2.91821684
77modulation by virus of host process (GO:0019054)2.91625348
78ensheathment of neurons (GO:0007272)2.88479321
79axon ensheathment (GO:0008366)2.88479321
80positive regulation of histone deacetylation (GO:0031065)2.88340556
81endothelial cell chemotaxis (GO:0035767)2.87841128
82synaptic vesicle docking involved in exocytosis (GO:0016081)2.86896590
83neutral amino acid transport (GO:0015804)2.85064874
84drug transport (GO:0015893)2.84757021
85myelination (GO:0042552)2.84507585
86tricarboxylic acid metabolic process (GO:0072350)2.84220629
87protein autoprocessing (GO:0016540)2.83105624
88regulation of chromatin binding (GO:0035561)2.80341321
89activation of Rac GTPase activity (GO:0032863)2.78605194
90phosphate ion transmembrane transport (GO:0035435)2.75091360
91iron ion import (GO:0097286)2.74694621
92response to arsenic-containing substance (GO:0046685)2.72690122
93thioester biosynthetic process (GO:0035384)2.71085737
94acyl-CoA biosynthetic process (GO:0071616)2.71085737
95negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.69142224
96negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.69124546
97glucose catabolic process (GO:0006007)2.67448110
98ear development (GO:0043583)2.67257249
99protein insertion into membrane (GO:0051205)2.67000122
100L-serine transport (GO:0015825)2.66867788
101very-low-density lipoprotein particle assembly (GO:0034379)2.66787450
102antibacterial humoral response (GO:0019731)2.65941568
103cellular response to virus (GO:0098586)2.65375624
104activation of MAPKKK activity (GO:0000185)2.65217527
105histone H3 deacetylation (GO:0070932)2.64323996
106lung epithelium development (GO:0060428)2.63098334
107adherens junction assembly (GO:0034333)2.62575085
108negative regulation of actin filament depolymerization (GO:0030835)2.61712800
109long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.61593509
110atrioventricular valve morphogenesis (GO:0003181)2.61282277
111axonemal dynein complex assembly (GO:0070286)2.60891695
112negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.60658288
113modulation by virus of host morphology or physiology (GO:0019048)2.59848091
114NADH metabolic process (GO:0006734)2.59827069
115synaptic vesicle exocytosis (GO:0016079)2.59303303
116dicarboxylic acid catabolic process (GO:0043649)2.58770062
117locomotory exploration behavior (GO:0035641)2.58159483
118antimicrobial humoral response (GO:0019730)2.57775284
119negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.57599796
120osteoblast development (GO:0002076)2.57123542
121proline metabolic process (GO:0006560)2.55839551
122beta-amyloid metabolic process (GO:0050435)2.55630338
123establishment of monopolar cell polarity (GO:0061162)2.55139276
124establishment or maintenance of monopolar cell polarity (GO:0061339)2.55139276
125protein targeting to plasma membrane (GO:0072661)2.53240623
126pentose-phosphate shunt (GO:0006098)2.53194699
127potassium ion homeostasis (GO:0055075)2.52984839
128L-phenylalanine catabolic process (GO:0006559)2.52627016
129erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.52627016
130fatty-acyl-CoA biosynthetic process (GO:0046949)2.51995678
131modulation by symbiont of host cellular process (GO:0044068)2.50716098
132L-amino acid import (GO:0043092)2.49369138
133regulation of glucose import in response to insulin stimulus (GO:2001273)2.48561135
134growth hormone secretion (GO:0030252)2.48333760
135maternal placenta development (GO:0001893)2.48085330
136glutamate metabolic process (GO:0006536)2.47668303
137cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.47331993
138retrograde transport, endosome to Golgi (GO:0042147)2.47180077
139urate metabolic process (GO:0046415)2.46888769
140regulation of ARF protein signal transduction (GO:0032012)2.46364037
141positive regulation of protein kinase C signaling (GO:0090037)2.46121466
142barbed-end actin filament capping (GO:0051016)2.46068004
143basement membrane organization (GO:0071711)2.44971426
144regulation of early endosome to late endosome transport (GO:2000641)2.44470702
1453-UTR-mediated mRNA stabilization (GO:0070935)2.43322502
146phosphatidylglycerol biosynthetic process (GO:0006655)2.41263558
147cell-substrate adherens junction assembly (GO:0007045)2.40562754
148focal adhesion assembly (GO:0048041)2.40562754
149regulation of cholesterol metabolic process (GO:0090181)2.40248215
150regulation of amyloid precursor protein catabolic process (GO:1902991)2.38387240
151regulation of ARF GTPase activity (GO:0032312)2.37991170
152positive regulation of protein dephosphorylation (GO:0035307)2.36652848
153neuronal ion channel clustering (GO:0045161)2.36623473
154innate immune response in mucosa (GO:0002227)2.36493635
155dopamine receptor signaling pathway (GO:0007212)2.36442084
156peptide biosynthetic process (GO:0043043)2.35826042
157epithelial cell differentiation involved in prostate gland development (GO:0060742)2.35550367
158glucose 6-phosphate metabolic process (GO:0051156)2.35121622
159alpha-linolenic acid metabolic process (GO:0036109)2.35116307
160establishment of mitochondrion localization (GO:0051654)2.34606452
161snRNA metabolic process (GO:0016073)2.34582563
162metanephric nephron tubule development (GO:0072234)2.33932344
163metanephric tubule development (GO:0072170)2.33932344
164positive regulation of insulin receptor signaling pathway (GO:0046628)2.33863407
165organic cation transport (GO:0015695)2.33193516
166quaternary ammonium group transport (GO:0015697)2.32933842
167L-amino acid transport (GO:0015807)2.31753503
168COPI coating of Golgi vesicle (GO:0048205)2.31129656
169Golgi transport vesicle coating (GO:0048200)2.31129656
170regulation of short-term neuronal synaptic plasticity (GO:0048172)2.30436471
171water-soluble vitamin biosynthetic process (GO:0042364)2.29661460
172protein localization to endosome (GO:0036010)2.29594098
173erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.29213091
174protoporphyrinogen IX metabolic process (GO:0046501)13.5816194
175protoporphyrinogen IX biosynthetic process (GO:0006782)12.4071371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human5.24485471
2GATA1_19941826_ChIP-Seq_K562_Human4.73561041
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.08609777
4* GATA1_19941827_ChIP-Seq_MEL_Mouse4.02400122
5TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.82453965
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.69649151
7KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse3.26521928
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.19348061
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.77296949
10SCL_19346495_ChIP-Seq_HPC-7_Human2.63690565
11GATA2_19941826_ChIP-Seq_K562_Human2.62390961
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.42240948
13ZNF263_19887448_ChIP-Seq_K562_Human2.38953312
14* GATA1_22383799_ChIP-Seq_G1ME_Mouse2.21934814
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.20462430
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.12784577
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.06301072
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.00385635
19LXR_22292898_ChIP-Seq_THP-1_Human1.98665892
20RXR_22158963_ChIP-Seq_LIVER_Mouse1.95186111
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90441631
22TET1_21451524_ChIP-Seq_MESCs_Mouse1.89613094
23SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.87207852
24TCF7_22412390_ChIP-Seq_EML_Mouse1.86683656
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.77736633
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75701962
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.74817872
28ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67875582
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.64789297
30UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.64035265
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.63361660
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61155554
33KDM2B_26808549_Chip-Seq_K562_Human1.60855773
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56644581
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55937932
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51070469
37GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50804929
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48809202
39* P68_20966046_ChIP-Seq_HELA_Human1.46987237
40AR_21909140_ChIP-Seq_LNCAP_Human1.46349536
41GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45822119
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45583313
43* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45225205
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44911698
45KDM2B_26808549_Chip-Seq_DND41_Human1.44391292
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43640165
47* ELF1_20517297_ChIP-Seq_JURKAT_Human1.42135017
48CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40341190
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38923045
50VDR_21846776_ChIP-Seq_THP-1_Human1.38712272
51MYC_22102868_ChIP-Seq_BL_Human1.38207121
52TP53_22127205_ChIP-Seq_IMR90_Human1.38060210
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37430819
54* PHF8_20622854_ChIP-Seq_HELA_Human1.36132300
55VDR_24763502_ChIP-Seq_THP-1_Human1.35616829
56* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34188056
57* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32738854
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.32653932
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32277049
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.31899340
61GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.29266619
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.26025003
63* E2F1_20622854_ChIP-Seq_HELA_Human1.25204852
64MAF_26560356_Chip-Seq_TH2_Human1.24061715
65TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.22941236
66GATA1_19941827_ChIP-Seq_MEL86_Mouse1.22904574
67* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22704239
68RACK7_27058665_Chip-Seq_MCF-7_Human1.22470698
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21810209
70RARB_24833708_ChIP-Seq_LIVER_Mouse1.21048113
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20332425
72SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.19931173
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19336765
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19284746
75SA1_27219007_Chip-Seq_Bcells_Human1.18644856
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18104599
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18036521
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16965059
79* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15627914
80MAF_26560356_Chip-Seq_TH1_Human1.14909076
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.12986735
82* REST_18959480_ChIP-ChIP_MESCs_Mouse1.12836822
83RARA_24833708_ChIP-Seq_LIVER_Mouse1.12576442
84CTCF_21964334_Chip-Seq_Bcells_Human1.11152475
85FOXP1_21924763_ChIP-Seq_HESCs_Human1.11061394
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10014051
87DROSHA_22980978_ChIP-Seq_HELA_Human1.09920624
88FOXA2_19822575_ChIP-Seq_HepG2_Human1.09238126
89* BCOR_27268052_Chip-Seq_Bcells_Human1.09207390
90NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08958807
91UTX_26944678_Chip-Seq_JUKART_Human1.08886081
92CTCF_26484167_Chip-Seq_Bcells_Mouse1.08552502
93CTCF_27219007_Chip-Seq_Bcells_Human1.08408820
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08385938
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08298475
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08020875
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07902832
98MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07743261
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07432256
100ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07120422
101CREB1_26743006_Chip-Seq_LNCaP_Human1.07001893
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06036513
103* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05843262
104SMC4_20622854_ChIP-Seq_HELA_Human1.05644381
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05215905
106P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05052221
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04732900
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04360220
109THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03790827
110* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03714405
111CTCF_20526341_ChIP-Seq_ESCs_Human1.03082085
112SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02350637
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01044170
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00539765
115SA1_27219007_Chip-Seq_ERYTHROID_Human1.00458828
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00409890
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99098029
118RUNX1_22412390_ChIP-Seq_EML_Mouse0.99018096
119PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98785180
120JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98758177
121* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97979920
122YY1_22570637_ChIP-Seq_MALME-3M_Human0.95576341
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95100972
124CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95009427
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94769374
126SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94159176
127TET1_21490601_ChIP-Seq_MESCs_Mouse0.93557184
128EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92473371
129SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92400466
130KDM2B_26808549_Chip-Seq_JURKAT_Human0.90760502
131VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89596829
132* TP63_22573176_ChIP-Seq_HFKS_Human0.89409183
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88314758
134NCOR1_26117541_ChIP-Seq_K562_Human0.86862424
135CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86343767
136BCL6_27268052_Chip-Seq_Bcells_Human0.85868884
137MITF_21258399_ChIP-Seq_MELANOMA_Human0.85410736
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84754471
139CLOCK_20551151_ChIP-Seq_293T_Human0.84745030
140FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84418335
141GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82259281
142WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80882992
143OCT4_19829295_ChIP-Seq_ESCs_Human0.79880172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level8.44211744
2MP0003656_abnormal_erythrocyte_physiolo8.25454658
3MP0003705_abnormal_hypodermis_morpholog3.57905078
4MP0004043_abnormal_pH_regulation3.46552550
5MP0004859_abnormal_synaptic_plasticity3.05736899
6MP0005083_abnormal_biliary_tract2.95481202
7MP0009278_abnormal_bone_marrow2.85964390
8MP0005076_abnormal_cell_differentiation2.70785246
9MP0002249_abnormal_larynx_morphology2.55106288
10MP0003329_amyloid_beta_deposits2.48369841
11MP0005636_abnormal_mineral_homeostasis2.46949079
12MP0002653_abnormal_ependyma_morphology2.38454738
13MP0000920_abnormal_myelination2.27093421
14MP0005360_urolithiasis2.18719157
15MP0000678_abnormal_parathyroid_gland2.07091816
16MP0001765_abnormal_ion_homeostasis1.98604287
17MP0003303_peritoneal_inflammation1.97191923
18MP0003878_abnormal_ear_physiology1.90596510
19MP0005377_hearing/vestibular/ear_phenot1.90596510
20MP0003806_abnormal_nucleotide_metabolis1.79848363
21MP0005409_darkened_coat_color1.78046643
22MP0004270_analgesia1.72551062
23MP0000003_abnormal_adipose_tissue1.68226062
24MP0001529_abnormal_vocalization1.67414404
25MP0005332_abnormal_amino_acid1.67038358
26MP0002139_abnormal_hepatobiliary_system1.65802767
27MP0002822_catalepsy1.62714743
28MP0003172_abnormal_lysosome_physiology1.62211785
29MP0000681_abnormal_thyroid_gland1.61441763
30MP0004885_abnormal_endolymph1.60949580
31MP0002064_seizures1.60797100
32MP0003635_abnormal_synaptic_transmissio1.58806710
33MP0009643_abnormal_urine_homeostasis1.58040579
34MP0003279_aneurysm1.52195485
35MP0008961_abnormal_basal_metabolism1.51861817
36MP0003690_abnormal_glial_cell1.50685140
37MP0001348_abnormal_lacrimal_gland1.50521011
38MP0006036_abnormal_mitochondrial_physio1.50195136
39MP0005171_absent_coat_pigmentation1.49888731
40MP0000566_synostosis1.47975433
41MP0001545_abnormal_hematopoietic_system1.47290123
42MP0005397_hematopoietic_system_phenotyp1.47290123
43MP0003453_abnormal_keratinocyte_physiol1.44692719
44MP0000751_myopathy1.44491296
45MP0002272_abnormal_nervous_system1.44062661
46MP0003195_calcinosis1.43381847
47MP0003191_abnormal_cellular_cholesterol1.41554786
48MP0000747_muscle_weakness1.38497891
49MP0000537_abnormal_urethra_morphology1.37092103
50MP0005451_abnormal_body_composition1.32129733
51MP0000604_amyloidosis1.30216551
52MP0002735_abnormal_chemical_nociception1.28906738
53MP0004215_abnormal_myocardial_fiber1.26594212
54MP0003566_abnormal_cell_adhesion1.25614655
55MP0008569_lethality_at_weaning1.25272997
56MP0010030_abnormal_orbit_morphology1.24487805
57MP0004381_abnormal_hair_follicle1.23785562
58MP0002909_abnormal_adrenal_gland1.21638883
59MP0001756_abnormal_urination1.21636941
60MP0004142_abnormal_muscle_tone1.20357013
61MP0003300_gastrointestinal_ulcer1.19709089
62MP0000013_abnormal_adipose_tissue1.19579142
63MP0009046_muscle_twitch1.19352765
64MP0001502_abnormal_circadian_rhythm1.18099902
65MP0005584_abnormal_enzyme/coenzyme_acti1.17745671
66MP0005670_abnormal_white_adipose1.16930434
67MP0008260_abnormal_autophagy1.16908418
68MP0001188_hyperpigmentation1.16868748
69MP0002229_neurodegeneration1.16390165
70MP0001958_emphysema1.15035323
71MP0008775_abnormal_heart_ventricle1.15013453
72MP0002736_abnormal_nociception_after1.14502855
73MP0009745_abnormal_behavioral_response1.13645002
74MP0002734_abnormal_mechanical_nocicepti1.13635059
75MP0009384_cardiac_valve_regurgitation1.11266995
76MP0003879_abnormal_hair_cell1.09886955
77MP0009780_abnormal_chondrocyte_physiolo1.09662006
78MP0008872_abnormal_physiological_respon1.09223802
79MP0005058_abnormal_lysosome_morphology1.09147811
80MP0009840_abnormal_foam_cell1.06936663
81MP0005535_abnormal_body_temperature1.06925351
82MP0009931_abnormal_skin_appearance1.05216909
83MP0003634_abnormal_glial_cell1.04784369
84MP0005375_adipose_tissue_phenotype1.04217316
85MP0001968_abnormal_touch/_nociception1.03046230
86MP0000749_muscle_degeneration1.02995952
87MP0003632_abnormal_nervous_system1.02868338
88MP0008438_abnormal_cutaneous_collagen1.01880182
89MP0003631_nervous_system_phenotype1.01770568
90MP0003633_abnormal_nervous_system1.00606970
91MP0002118_abnormal_lipid_homeostasis0.99727059
92MP0002063_abnormal_learning/memory/cond0.93660820
93MP0006054_spinal_hemorrhage0.93069342
94MP0002733_abnormal_thermal_nociception0.92472214
95MP0000467_abnormal_esophagus_morphology0.91673372
96MP0000015_abnormal_ear_pigmentation0.91463349
97MP0002837_dystrophic_cardiac_calcinosis0.89802081
98MP0001270_distended_abdomen0.88110162
99MP0003880_abnormal_central_pattern0.86974605
100MP0002098_abnormal_vibrissa_morphology0.86115304
101MP0004233_abnormal_muscle_weight0.85331516
102MP0002067_abnormal_sensory_capabilities0.85309174
103MP0002066_abnormal_motor_capabilities/c0.85247791
104MP0005508_abnormal_skeleton_morphology0.83296821
105MP0001970_abnormal_pain_threshold0.83181755
106MP0005623_abnormal_meninges_morphology0.81705175
107MP0003075_altered_response_to0.81191628
108MP0001486_abnormal_startle_reflex0.81187325
109MP0001664_abnormal_digestion0.81165566
110MP0000858_altered_metastatic_potential0.80961580
111MP0004811_abnormal_neuron_physiology0.80166407
112MP0003186_abnormal_redox_activity0.80096522
113MP0005503_abnormal_tendon_morphology0.79244740
114MP0003436_decreased_susceptibility_to0.78888338
115MP0001666_abnormal_nutrient_absorption0.77441281
116MP0003111_abnormal_nucleus_morphology0.76418415
117MP0004924_abnormal_behavior0.76418222
118MP0005386_behavior/neurological_phenoty0.76418222
119MP0001849_ear_inflammation0.75631163
120MP0003283_abnormal_digestive_organ0.74461894
121MP0004858_abnormal_nervous_system0.73719007
122MP0004130_abnormal_muscle_cell0.73154080
123MP0004133_heterotaxia0.73038209
124MP0002932_abnormal_joint_morphology0.72009183
125MP0004264_abnormal_extraembryonic_tissu0.71721030
126MP0002060_abnormal_skin_morphology0.71225441
127MP0002089_abnormal_postnatal_growth/wei0.70358868
128MP0002269_muscular_atrophy0.70093049
129MP0008875_abnormal_xenobiotic_pharmacok0.70048756
130MP0003123_paternal_imprinting0.69648088
131MP0008874_decreased_physiological_sensi0.69623197
132MP0003942_abnormal_urinary_system0.69284508
133MP0005423_abnormal_somatic_nervous0.69246666
134MP0000538_abnormal_urinary_bladder0.69168179
135MP0004085_abnormal_heartbeat0.69074803
136MP0002877_abnormal_melanocyte_morpholog0.68302203
137MP0005621_abnormal_cell_physiology0.68296705
138MP0002136_abnormal_kidney_physiology0.67916144
139MP0000955_abnormal_spinal_cord0.67491704
140MP0002572_abnormal_emotion/affect_behav0.66631427
141MP0005666_abnormal_adipose_tissue0.66161011
142MP0003252_abnormal_bile_duct0.65817783
143MP0000609_abnormal_liver_physiology0.63631564
144MP0009333_abnormal_splenocyte_physiolog0.63225130
145MP0002796_impaired_skin_barrier0.63077637
146MP0000230_abnormal_systemic_arterial0.62883957
147MP0003045_fibrosis0.62661414
148MP0004947_skin_inflammation0.62421725
149MP0000767_abnormal_smooth_muscle0.62393130
150MP0010234_abnormal_vibrissa_follicle0.61745166
151MP0003091_abnormal_cell_migration0.61636145
152MP0002933_joint_inflammation0.60985372
153MP0005394_taste/olfaction_phenotype0.60511048
154MP0005499_abnormal_olfactory_system0.60511048
155MP0002078_abnormal_glucose_homeostasis0.60210006
156MP0010771_integument_phenotype0.59857435
157MP0010329_abnormal_lipoprotein_level0.59507061
158MP0002970_abnormal_white_adipose0.59121769
159MP0003948_abnormal_gas_homeostasis0.58711336
160MP0000733_abnormal_muscle_development0.58242915
161MP0005501_abnormal_skin_physiology0.58150180
162MP0005452_abnormal_adipose_tissue0.57745491
163MP0001440_abnormal_grooming_behavior0.56700163
164MP0002116_abnormal_craniofacial_bone0.55631631
165MP0002138_abnormal_hepatobiliary_system0.55443613
166MP0004185_abnormal_adipocyte_glucose0.54663805
167MP0002972_abnormal_cardiac_muscle0.54612673
168MP0002882_abnormal_neuron_morphology0.54234038
169MP0000534_abnormal_ureter_morphology0.52495163
170MP0000026_abnormal_inner_ear0.51170712

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)9.91909422
2Poikilocytosis (HP:0004447)8.07704098
3Acanthocytosis (HP:0001927)5.64423243
4Reticulocytosis (HP:0001923)5.52025529
5Diaphragmatic weakness (HP:0009113)5.02789801
6Cholelithiasis (HP:0001081)4.79068934
7Insomnia (HP:0100785)4.74304050
8Abnormal gallbladder morphology (HP:0012437)4.45585339
9Increased circulating renin level (HP:0000848)4.23221838
10Hypochromic microcytic anemia (HP:0004840)4.19958656
11Paralysis (HP:0003470)4.07898691
12Hyperbilirubinemia (HP:0002904)3.97611157
13Obstructive sleep apnea (HP:0002870)3.71620606
14Ileus (HP:0002595)3.58996204
15Hypokalemic alkalosis (HP:0001949)3.45124914
16Cholecystitis (HP:0001082)3.31732482
17Abnormal gallbladder physiology (HP:0012438)3.31732482
18Metabolic alkalosis (HP:0200114)3.30384857
19Distal upper limb amyotrophy (HP:0007149)3.28461851
20Upper limb amyotrophy (HP:0009129)3.28461851
21Abnormality of the gallbladder (HP:0005264)3.24157127
22Hyperacusis (HP:0010780)3.23899343
23Abnormality of reticulocytes (HP:0004312)3.17440935
24Broad distal phalanx of finger (HP:0009836)3.16886479
25J-shaped sella turcica (HP:0002680)3.12277469
26Cerebral aneurysm (HP:0004944)3.10635044
27Ulnar bowing (HP:0003031)3.10402502
28Gout (HP:0001997)3.07060316
29Broad face (HP:0000283)3.05093935
30Hypomagnesemia (HP:0002917)3.03988287
31Abnormality of sodium homeostasis (HP:0010931)3.02104563
32Osteomalacia (HP:0002749)2.98366137
33Nasal polyposis (HP:0100582)2.97567655
34Abnormality of the nasal mucosa (HP:0000433)2.96888597
35Confusion (HP:0001289)2.95200049
36Atelectasis (HP:0100750)2.95195878
37Hyperactive renin-angiotensin system (HP:0000841)2.93214624
38Neurofibrillary tangles (HP:0002185)2.92573048
39Stridor (HP:0010307)2.92381802
40Hyponatremia (HP:0002902)2.91391690
41Cervical subluxation (HP:0003308)2.88914863
42Thin bony cortex (HP:0002753)2.87482823
43Abnormality of magnesium homeostasis (HP:0004921)2.82908404
44Cerebral inclusion bodies (HP:0100314)2.82404827
45Global brain atrophy (HP:0002283)2.80069569
46Abnormal hemoglobin (HP:0011902)2.74357560
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.71362537
48Hand muscle atrophy (HP:0009130)2.70833750
49Supranuclear gaze palsy (HP:0000605)2.67069045
50Hyperaldosteronism (HP:0000859)2.54802691
51Myokymia (HP:0002411)2.52889260
52Hypochromic anemia (HP:0001931)2.51244282
53Depression (HP:0000716)2.50503617
54Polyuria (HP:0000103)2.49745918
55Polycythemia (HP:0001901)2.49219751
56Lymphangioma (HP:0100764)2.48743329
57Abnormality of renin-angiotensin system (HP:0000847)2.45697577
58Abnormality of chloride homeostasis (HP:0011422)2.44540247
59Turricephaly (HP:0000262)2.43030131
60Abnormality of polysaccharide metabolism (HP:0011012)2.42394720
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.42394720
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.42394720
63Annular pancreas (HP:0001734)2.41342535
64Renal salt wasting (HP:0000127)2.40971434
65Hemorrhage of the eye (HP:0011885)2.39179942
66Ketoacidosis (HP:0001993)2.38332598
67Distal lower limb amyotrophy (HP:0008944)2.36571878
68Abnormal urine output (HP:0012590)2.36217342
69Anxiety (HP:0000739)2.34626487
70Abnormality of the fingertips (HP:0001211)2.33618555
71Delusions (HP:0000746)2.32944935
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.30725147
73Degeneration of the lateral corticospinal tracts (HP:0002314)2.30725147
74Intention tremor (HP:0002080)2.29373251
75Increased serum ferritin (HP:0003281)2.29128780
76Long palpebral fissure (HP:0000637)2.26290657
77Nonimmune hydrops fetalis (HP:0001790)2.26052162
78Onion bulb formation (HP:0003383)2.25273177
79Dysostosis multiplex (HP:0000943)2.23498532
80Protrusio acetabuli (HP:0003179)2.22260583
81Metaphyseal cupping (HP:0003021)2.21056403
82Short nail (HP:0001799)2.19946853
83Mucopolysacchariduria (HP:0008155)2.19295126
84Urinary glycosaminoglycan excretion (HP:0003541)2.19295126
85Nuclear cataract (HP:0100018)2.19064585
86Abnormal drinking behavior (HP:0030082)2.18791457
87Polydipsia (HP:0001959)2.18791457
88Vertebral compression fractures (HP:0002953)2.17273904
89Postural instability (HP:0002172)2.16265197
90Spastic gait (HP:0002064)2.15767936
91Papilledema (HP:0001085)2.15582751
92Ankle clonus (HP:0011448)2.14580629
93Shallow orbits (HP:0000586)2.13676962
94Cutaneous photosensitivity (HP:0000992)2.12603444
95Increased cerebral lipofuscin (HP:0011813)2.12510245
96Abnormal auditory evoked potentials (HP:0006958)2.12363119
97Abnormality of renal excretion (HP:0011036)2.11584794
98Rickets (HP:0002748)2.11378762
99Joint stiffness (HP:0001387)2.10756582
100Distal lower limb muscle weakness (HP:0009053)2.10587474
101Psychosis (HP:0000709)2.10311711
102Abnormality of the thoracic spine (HP:0100711)2.10064558
103Ketosis (HP:0001946)2.08240852
104Visual hallucinations (HP:0002367)2.07542351
105Myopathic facies (HP:0002058)2.07299801
106Flattened epiphyses (HP:0003071)2.06844730
107Spastic tetraparesis (HP:0001285)2.05646129
108Microcytic anemia (HP:0001935)2.04618289
109Urinary urgency (HP:0000012)2.03519717
110Easy fatigability (HP:0003388)2.03082108
111Renal tubular acidosis (HP:0001947)2.02790834
112Increased neuronal autofluorescent lipopigment (HP:0002074)1.99404287
113Testicular atrophy (HP:0000029)1.99346101
114Metabolic acidosis (HP:0001942)1.98882677
115Truncal ataxia (HP:0002078)1.97769749
116Premature rupture of membranes (HP:0001788)1.97132240
117Increased connective tissue (HP:0009025)1.96365613
118Abnormality of the aortic arch (HP:0012303)1.96224453
119Hepatocellular carcinoma (HP:0001402)1.95841275
120Termporal pattern (HP:0011008)1.94615632
121Insidious onset (HP:0003587)1.94615632
122Hypoglycemic coma (HP:0001325)1.93590516
123Abnormality of the corticospinal tract (HP:0002492)1.93366663
124Rectal prolapse (HP:0002035)1.92281527
125Proximal tubulopathy (HP:0000114)1.90812889
126Dysmetria (HP:0001310)1.90026906
127Pheochromocytoma (HP:0002666)1.89848251
128Scanning speech (HP:0002168)1.88392626
129Difficulty climbing stairs (HP:0003551)1.88080332
130Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87759102
131Precocious puberty (HP:0000826)1.87433072
132Alkalosis (HP:0001948)1.86661285
133Hyperthyroidism (HP:0000836)1.85872210
134Thoracic kyphosis (HP:0002942)1.85823509
135Achilles tendon contracture (HP:0001771)1.85767411
136Hypertensive crisis (HP:0100735)1.85712187
137Abnormality of the distal phalanges of the toes (HP:0010182)1.83345715
138Pancreatic islet-cell hyperplasia (HP:0004510)1.83157651
139Biconcave vertebral bodies (HP:0004586)1.82351740
140Cerebral hypomyelination (HP:0006808)1.81398342
141Mitral regurgitation (HP:0001653)1.81087886
142Cerebral palsy (HP:0100021)1.79108676
143Hypertriglyceridemia (HP:0002155)1.78926781
144Abnormal respiratory epithelium morphology (HP:0012253)1.78678812
145Abnormal respiratory motile cilium morphology (HP:0005938)1.78678812
146Nephrocalcinosis (HP:0000121)1.78664421
147Generalized aminoaciduria (HP:0002909)1.78418406
148Tetany (HP:0001281)1.76706775
149Abnormality of iron homeostasis (HP:0011031)1.76096119
150Impaired social interactions (HP:0000735)1.76039587
151Abnormal social behavior (HP:0012433)1.76039587
152Germ cell neoplasia (HP:0100728)1.75425345
153Spastic paraparesis (HP:0002313)1.75064815
154Neuronal loss in central nervous system (HP:0002529)1.74497705
155Bronchomalacia (HP:0002780)1.74202989
156Bowing of the arm (HP:0006488)1.74083971
157Bowed forearm bones (HP:0003956)1.74083971
158Truncus arteriosus (HP:0001660)1.73836332
159Mildly elevated creatine phosphokinase (HP:0008180)1.73801182
160Disproportionate tall stature (HP:0001519)1.73658022
161Hypercortisolism (HP:0001578)1.72368198
162Fragile skin (HP:0001030)1.71975199
163Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71940547
164Abnormality of fatty-acid metabolism (HP:0004359)1.71898932
165Long toe (HP:0010511)1.71624835
166Hyperparathyroidism (HP:0000843)1.71447844
167Abnormality of transition element cation homeostasis (HP:0011030)1.71287256
168Cerebral hemorrhage (HP:0001342)1.71201279
169Pointed chin (HP:0000307)1.70859128
170Abnormality of purine metabolism (HP:0004352)1.69027479
171Vomiting (HP:0002013)1.68687098
172Hyperuricemia (HP:0002149)1.68159855
173Increased purine levels (HP:0004368)1.68159855
174Progressive microcephaly (HP:0000253)1.67051354
175Hypercalciuria (HP:0002150)1.66600280
176Clonus (HP:0002169)1.65614583
177Neuroendocrine neoplasm (HP:0100634)1.65168005
178Delayed CNS myelination (HP:0002188)1.63851350

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.89532972
2SIK13.64622577
3EIF2AK13.64440628
4OXSR13.37432816
5STK392.83161774
6PRPF4B2.70487827
7SMG12.61772185
8BCKDK2.58919644
9EPHA22.42237759
10MAPK152.39572383
11PRKD32.37468691
12TRIB32.15929883
13WNK32.07112630
14EPHB11.95741592
15NTRK11.90912789
16BRSK11.84126645
17KSR21.83789135
18MAPKAPK51.79945167
19SCYL21.74101199
20MAP2K31.72702835
21SGK4941.67658700
22SGK2231.67658700
23WNK11.64774314
24DAPK21.60178641
25IRAK31.59425740
26EEF2K1.56807022
27RPS6KA21.56796097
28STK41.54584065
29TAOK11.52617660
30TESK11.51368939
31SIK21.46769526
32PRKD21.41597421
33TAOK21.38586522
34PRKCH1.37148152
35MAP3K91.34619774
36MST1R1.30254030
37TNK21.24807307
38TLK11.24023768
39CAMK1G1.22366117
40NME21.20692572
41TESK21.20594457
42CDK191.16918544
43PAK61.16537685
44UHMK11.14416011
45MAP3K61.14082025
46RPS6KL11.13868850
47RPS6KC11.13868850
48MET1.12506663
49MAP3K31.11584388
50PTK61.09147696
51NTRK31.07353951
52EPHA41.06192042
53NEK11.06148710
54MAP3K81.06083783
55ZAK1.05816745
56CDK151.05024682
57TTN1.02330996
58MINK11.01348925
59BRAF1.01017862
60MAP2K21.00691006
61CDK141.00345667
62CDK50.99695313
63MAP3K110.99562210
64STK100.97173905
65MTOR0.96452883
66RPS6KA60.95480085
67CDK180.94504600
68CDK11A0.93934721
69PAK40.91779720
70PKN20.89914348
71PRKAA10.87733442
72HIPK20.86198908
73ICK0.85242195
74RET0.83260918
75MAPK110.81686229
76PDPK10.81210120
77RIPK10.81136217
78PTK2B0.79711469
79ERN10.78858343
80MAP3K20.78297011
81MAPKAPK30.76747917
82SGK30.76261440
83KDR0.75868988
84TBK10.75811389
85MAP3K70.73776661
86JAK20.73684078
87CDC70.72052747
88MAP3K10.71497362
89LRRK20.68861364
90CAMKK10.67136175
91TTK0.67095588
92MAP2K60.66454367
93SGK10.66175636
94PIM20.65814001
95BRD40.65396669
96ROCK20.65011231
97PAK30.64554942
98FGFR40.64184625
99SIK30.63714222
100ZAP700.62377802
101PKN10.60739382
102GRK60.60534948
103MAP2K10.60405686
104AURKA0.59630595
105MAP4K10.56911804
106LMTK20.55857594
107MAP2K40.55595937
108DDR20.55457881
109PDK10.54758989
110PNCK0.54409052
111NEK20.54328012
112DYRK1B0.53992625
113RPS6KA50.53380323
114PHKG10.52675189
115PHKG20.52675189
116CLK10.52432983
117BUB10.52367517
118CDC42BPA0.51960742
119MUSK0.49760918
120MAPK120.49675075
121EPHB20.48711020
122STK380.48449332
123MARK20.48163591
124MAP3K100.47424434
125CAMK1D0.46185544
126DYRK1A0.45184518
127PDGFRA0.44888557
128IRAK20.44526936
129PRKCI0.43798580
130PTK20.43670098
131MAP3K130.42987604
132BMX0.42305306
133PRKACG0.42056184
134RPS6KA30.40987217
135CDK120.40687320
136CAMK2B0.40632882
137ARAF0.39997532
138MAPK80.39569135
139PRKD10.38919923
140CAMK2D0.38552525
141FYN0.38487451
142ERBB20.37503791
143RPS6KA10.36711905
144TYRO30.35627291
145MAPK40.35532181
146CAMK40.34815755
147CAMK10.34504807
148ABL20.33881254
149CHUK0.31820237

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008604.66985158
2Vitamin B6 metabolism_Homo sapiens_hsa007503.43381207
3Nitrogen metabolism_Homo sapiens_hsa009103.15543993
4Other glycan degradation_Homo sapiens_hsa005112.90002975
5Notch signaling pathway_Homo sapiens_hsa043302.78457072
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.75456202
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.72335529
8Butanoate metabolism_Homo sapiens_hsa006502.24356245
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.20691132
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20475838
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.15211421
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09068809
13Propanoate metabolism_Homo sapiens_hsa006402.03115279
14Fatty acid elongation_Homo sapiens_hsa000622.02837238
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97242058
16Pyruvate metabolism_Homo sapiens_hsa006201.94225959
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89377291
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87792554
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85319243
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.83853063
21VEGF signaling pathway_Homo sapiens_hsa043701.82148463
22Collecting duct acid secretion_Homo sapiens_hsa049661.81092505
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.78147723
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.75687022
25Fatty acid metabolism_Homo sapiens_hsa012121.72683655
26Fructose and mannose metabolism_Homo sapiens_hsa000511.72220390
27Systemic lupus erythematosus_Homo sapiens_hsa053221.64454587
28Chronic myeloid leukemia_Homo sapiens_hsa052201.63439915
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62391982
30Acute myeloid leukemia_Homo sapiens_hsa052211.61257421
31Sulfur metabolism_Homo sapiens_hsa009201.55357501
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53122828
33Fatty acid degradation_Homo sapiens_hsa000711.52317091
34Alcoholism_Homo sapiens_hsa050341.51822872
35Bile secretion_Homo sapiens_hsa049761.38229453
36Synaptic vesicle cycle_Homo sapiens_hsa047211.38066362
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.35484940
38mTOR signaling pathway_Homo sapiens_hsa041501.33496085
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.30654308
40Longevity regulating pathway - mammal_Homo sapiens_hsa042111.29127904
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.29010952
42GABAergic synapse_Homo sapiens_hsa047271.20147852
43ABC transporters_Homo sapiens_hsa020101.18518640
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18228731
45Steroid biosynthesis_Homo sapiens_hsa001001.16361280
46Gastric acid secretion_Homo sapiens_hsa049711.15768206
47Phenylalanine metabolism_Homo sapiens_hsa003601.15574852
48Carbon metabolism_Homo sapiens_hsa012001.15344902
49Insulin signaling pathway_Homo sapiens_hsa049101.14472744
50Endometrial cancer_Homo sapiens_hsa052131.14304543
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13862971
52Prion diseases_Homo sapiens_hsa050201.13072608
53Malaria_Homo sapiens_hsa051441.06344052
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06096622
55ErbB signaling pathway_Homo sapiens_hsa040121.04667753
56Adipocytokine signaling pathway_Homo sapiens_hsa049201.02808120
57Axon guidance_Homo sapiens_hsa043601.01973685
58Tryptophan metabolism_Homo sapiens_hsa003801.01966922
59Insulin secretion_Homo sapiens_hsa049111.01781941
60GnRH signaling pathway_Homo sapiens_hsa049121.01680950
61Pancreatic cancer_Homo sapiens_hsa052121.00863624
62Choline metabolism in cancer_Homo sapiens_hsa052311.00043250
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99557741
64beta-Alanine metabolism_Homo sapiens_hsa004100.98073127
65Estrogen signaling pathway_Homo sapiens_hsa049150.97630664
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.96516773
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96128231
68Glutathione metabolism_Homo sapiens_hsa004800.96070614
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95394230
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94619609
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92694547
72Salivary secretion_Homo sapiens_hsa049700.90577055
73Peroxisome_Homo sapiens_hsa041460.88819111
74Galactose metabolism_Homo sapiens_hsa000520.87452348
75Circadian entrainment_Homo sapiens_hsa047130.87205276
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86262319
77Long-term potentiation_Homo sapiens_hsa047200.85022151
78Melanogenesis_Homo sapiens_hsa049160.84517191
79Arginine and proline metabolism_Homo sapiens_hsa003300.84245286
80Biosynthesis of amino acids_Homo sapiens_hsa012300.83849238
81Hepatitis C_Homo sapiens_hsa051600.82740612
82Renal cell carcinoma_Homo sapiens_hsa052110.82396997
83Selenocompound metabolism_Homo sapiens_hsa004500.80989037
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79489485
85Inositol phosphate metabolism_Homo sapiens_hsa005620.78477433
86Glutamatergic synapse_Homo sapiens_hsa047240.77162869
87Sphingolipid metabolism_Homo sapiens_hsa006000.76119625
88PPAR signaling pathway_Homo sapiens_hsa033200.75717576
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75642399
90Lysosome_Homo sapiens_hsa041420.74737569
91Morphine addiction_Homo sapiens_hsa050320.74590333
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.74529782
93* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74226333
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74197039
95Pancreatic secretion_Homo sapiens_hsa049720.74139144
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72415020
97Lysine degradation_Homo sapiens_hsa003100.72142392
98Thyroid hormone synthesis_Homo sapiens_hsa049180.71129618
99Prolactin signaling pathway_Homo sapiens_hsa049170.70653319
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70008289
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69410484
102Tyrosine metabolism_Homo sapiens_hsa003500.68805399
103ECM-receptor interaction_Homo sapiens_hsa045120.68722664
104Folate biosynthesis_Homo sapiens_hsa007900.68080721
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67881473
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65167250
107Bladder cancer_Homo sapiens_hsa052190.64970604
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64769780
109Dorso-ventral axis formation_Homo sapiens_hsa043200.63748875
110Focal adhesion_Homo sapiens_hsa045100.62907613
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62761103
112Insulin resistance_Homo sapiens_hsa049310.62681608
113Arginine biosynthesis_Homo sapiens_hsa002200.62648725
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.60796304
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60221197
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59929871
117Ether lipid metabolism_Homo sapiens_hsa005650.59396209
118Glycerolipid metabolism_Homo sapiens_hsa005610.58939287
119N-Glycan biosynthesis_Homo sapiens_hsa005100.58852649
120Glioma_Homo sapiens_hsa052140.58647897
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.58637761
122Non-small cell lung cancer_Homo sapiens_hsa052230.56859085
123Cardiac muscle contraction_Homo sapiens_hsa042600.56481168
124Thyroid cancer_Homo sapiens_hsa052160.56103581
125Dopaminergic synapse_Homo sapiens_hsa047280.55159288
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52379138
127Long-term depression_Homo sapiens_hsa047300.51691612
128Small cell lung cancer_Homo sapiens_hsa052220.51632113
129B cell receptor signaling pathway_Homo sapiens_hsa046620.50859433
130Sulfur relay system_Homo sapiens_hsa041220.50348153
131Gap junction_Homo sapiens_hsa045400.50167627
132Oocyte meiosis_Homo sapiens_hsa041140.49745863
133Apoptosis_Homo sapiens_hsa042100.49220789
134Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49152374
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49122124
136Amoebiasis_Homo sapiens_hsa051460.48904140
137Fatty acid biosynthesis_Homo sapiens_hsa000610.48683684
138Mineral absorption_Homo sapiens_hsa049780.48324913
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.48105620
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47793306
141Rap1 signaling pathway_Homo sapiens_hsa040150.45982206
142Amphetamine addiction_Homo sapiens_hsa050310.45759262
143Protein digestion and absorption_Homo sapiens_hsa049740.45211405
144Endocytosis_Homo sapiens_hsa041440.44848140
145Pentose phosphate pathway_Homo sapiens_hsa000300.43801969
146Parkinsons disease_Homo sapiens_hsa050120.43207843
147Glucagon signaling pathway_Homo sapiens_hsa049220.42932863
148Cocaine addiction_Homo sapiens_hsa050300.42663872
149Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41665124
150Olfactory transduction_Homo sapiens_hsa047400.41592318
151Hepatitis B_Homo sapiens_hsa051610.40791425
152Salmonella infection_Homo sapiens_hsa051320.40514477
153Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40468622
154Nicotine addiction_Homo sapiens_hsa050330.40159857
155Colorectal cancer_Homo sapiens_hsa052100.39834314
156AMPK signaling pathway_Homo sapiens_hsa041520.39116232
157HIF-1 signaling pathway_Homo sapiens_hsa040660.39006246
158Renin secretion_Homo sapiens_hsa049240.38973138
159Phospholipase D signaling pathway_Homo sapiens_hsa040720.38580965
160* Metabolic pathways_Homo sapiens_hsa011000.37892155
161Histidine metabolism_Homo sapiens_hsa003400.37792010
162Type II diabetes mellitus_Homo sapiens_hsa049300.37279853
163Cholinergic synapse_Homo sapiens_hsa047250.37086752
164Vibrio cholerae infection_Homo sapiens_hsa051100.35418687

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