PIGS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.35083275
2Golgi transport vesicle coating (GO:0048200)5.35083275
3barbed-end actin filament capping (GO:0051016)5.32191792
4proline biosynthetic process (GO:0006561)4.90150215
5dermatan sulfate metabolic process (GO:0030205)4.65975210
6DNA deamination (GO:0045006)4.63507466
7dermatan sulfate biosynthetic process (GO:0030208)4.46319235
8regulation of translational fidelity (GO:0006450)4.22531223
9sodium ion export (GO:0071436)4.13546297
10regulation of protein heterodimerization activity (GO:0043497)4.12868492
11NADH metabolic process (GO:0006734)4.07306886
12positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.89698933
13glucose catabolic process (GO:0006007)3.84662162
14amyloid precursor protein catabolic process (GO:0042987)3.78952953
15glucose 6-phosphate metabolic process (GO:0051156)3.75794169
16lens fiber cell development (GO:0070307)3.72631136
17ribosomal small subunit biogenesis (GO:0042274)3.69116963
18sequestering of actin monomers (GO:0042989)3.59934951
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.53832325
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.53832325
21chaperone mediated protein folding requiring cofactor (GO:0051085)3.48964244
22peptidyl-proline hydroxylation (GO:0019511)3.46516331
23viral transcription (GO:0019083)3.45068140
24L-serine transport (GO:0015825)3.40943053
25pentose metabolic process (GO:0019321)3.34882463
26oxidative phosphorylation (GO:0006119)3.34730016
27protoporphyrinogen IX metabolic process (GO:0046501)3.33691208
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25555937
29serine transport (GO:0032329)3.22877941
30cellular response to interferon-beta (GO:0035458)3.22703216
31cellular potassium ion homeostasis (GO:0030007)3.22512974
32positive regulation of lamellipodium assembly (GO:0010592)3.18998881
33purine-containing compound salvage (GO:0043101)3.18718895
34protein targeting to ER (GO:0045047)3.17795353
35cotranslational protein targeting to membrane (GO:0006613)3.16022176
36antigen processing and presentation of endogenous antigen (GO:0019883)3.14810983
37translational termination (GO:0006415)3.14344374
38positive regulation by symbiont of host defense response (GO:0052509)3.13669627
39modulation by symbiont of host defense response (GO:0052031)3.13669627
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.13669627
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.13669627
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.13669627
43modulation by symbiont of host immune response (GO:0052553)3.13669627
44chondroitin sulfate biosynthetic process (GO:0030206)3.13426946
45T cell migration (GO:0072678)3.13317418
464-hydroxyproline metabolic process (GO:0019471)3.12355440
47oxaloacetate metabolic process (GO:0006107)3.12135620
48folic acid metabolic process (GO:0046655)3.11465494
49blood vessel maturation (GO:0001955)3.08725631
50guanosine-containing compound biosynthetic process (GO:1901070)3.08606131
51protein localization to endoplasmic reticulum (GO:0070972)3.06605369
52mitochondrial fusion (GO:0008053)3.05243953
53heme biosynthetic process (GO:0006783)3.04332164
54formation of translation preinitiation complex (GO:0001731)3.04330194
55protein hydroxylation (GO:0018126)3.04314270
56proline metabolic process (GO:0006560)3.04143045
57chondroitin sulfate catabolic process (GO:0030207)3.02676727
58tricarboxylic acid cycle (GO:0006099)3.01922234
59DNA strand elongation involved in DNA replication (GO:0006271)3.01710710
60establishment of protein localization to endoplasmic reticulum (GO:0072599)3.01216053
61translational elongation (GO:0006414)3.01135666
62antigen processing and presentation via MHC class Ib (GO:0002475)3.00738642
63purine nucleotide salvage (GO:0032261)2.98630351
64monosaccharide biosynthetic process (GO:0046364)2.98591552
65regulation of mitochondrial translation (GO:0070129)2.94752611
66nucleobase-containing small molecule interconversion (GO:0015949)2.92137201
67gluconeogenesis (GO:0006094)2.92103306
68Arp2/3 complex-mediated actin nucleation (GO:0034314)2.91855578
69tricarboxylic acid metabolic process (GO:0072350)2.90613037
70UTP biosynthetic process (GO:0006228)2.88734082
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.88532752
72regulation of interferon-beta biosynthetic process (GO:0045357)2.88033298
73tRNA aminoacylation for protein translation (GO:0006418)2.87466376
74UV protection (GO:0009650)2.86136606
75immunoglobulin mediated immune response (GO:0016064)2.85945185
76DNA strand elongation (GO:0022616)2.85881224
77maturation of SSU-rRNA (GO:0030490)2.85720366
78IMP biosynthetic process (GO:0006188)2.84609783
79glycolytic process (GO:0006096)2.83179648
80retinal rod cell development (GO:0046548)2.82494044
81regulation of superoxide anion generation (GO:0032928)2.81891782
82pentose-phosphate shunt (GO:0006098)2.81313480
83positive regulation of lamellipodium organization (GO:1902745)2.81220744
84viral life cycle (GO:0019058)2.81218393
85tRNA aminoacylation (GO:0043039)2.80048018
86amino acid activation (GO:0043038)2.80048018
87lipopolysaccharide metabolic process (GO:0008653)2.79976861
88glycosphingolipid catabolic process (GO:0046479)2.79413053
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.78213000
90galactose catabolic process (GO:0019388)2.77906856
91antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.76643510
92hexose biosynthetic process (GO:0019319)2.76208303
93nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.75926075
94ribosomal small subunit assembly (GO:0000028)2.74704589
95pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.74440632
96ATP synthesis coupled proton transport (GO:0015986)2.74137195
97energy coupled proton transport, down electrochemical gradient (GO:0015985)2.74137195
98regulation of mammary gland epithelial cell proliferation (GO:0033599)2.73307994
99leukocyte aggregation (GO:0070486)2.73274687
100protein retention in ER lumen (GO:0006621)2.73197642
101UTP metabolic process (GO:0046051)2.73046283
102mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.72814280
103pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.72514048
104protoporphyrinogen IX biosynthetic process (GO:0006782)2.72300819
105ribonucleoprotein complex biogenesis (GO:0022613)2.70511045
106activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.69892868
107negative regulation of glycoprotein biosynthetic process (GO:0010561)2.69762217
108ribosomal large subunit biogenesis (GO:0042273)2.69628953
109protein deneddylation (GO:0000338)2.69565230
110negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.69371896
111proteasome assembly (GO:0043248)2.69159125
112amyloid precursor protein metabolic process (GO:0042982)2.68537317
113folic acid-containing compound biosynthetic process (GO:0009396)2.66610552
114virion assembly (GO:0019068)2.66315227
115positive regulation of nuclease activity (GO:0032075)2.65396578
116negative regulation of glycoprotein metabolic process (GO:1903019)2.65365112
117maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.64725546
118lipopolysaccharide biosynthetic process (GO:0009103)2.63918827
119phagocytosis, engulfment (GO:0006911)2.63914158
120pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.63641380
121peptide catabolic process (GO:0043171)2.62901530
122GTP biosynthetic process (GO:0006183)2.61493842
123positive regulation of chemokine biosynthetic process (GO:0045080)2.60559742
124COPII vesicle coating (GO:0048208)2.60519008
125deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.59445510
126vesicle coating (GO:0006901)2.58716687
127translational initiation (GO:0006413)2.58609532
128GDP-mannose metabolic process (GO:0019673)2.58121797
129endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.57841015
130DNA replication initiation (GO:0006270)2.57607101
131positive thymic T cell selection (GO:0045059)2.57398418
132purine nucleobase biosynthetic process (GO:0009113)2.56677652
133negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.56422021
134glycolipid catabolic process (GO:0019377)2.55821654
135positive regulation of triglyceride biosynthetic process (GO:0010867)2.53639557
136pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.53402618
137DNA unwinding involved in DNA replication (GO:0006268)2.53199235
138regulation of B cell receptor signaling pathway (GO:0050855)2.52036917
139respiratory electron transport chain (GO:0022904)2.51908369
140peptidyl-arginine omega-N-methylation (GO:0035247)2.50726738
141folic acid transport (GO:0015884)2.50573673
142negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.49956496
143telomere maintenance via semi-conservative replication (GO:0032201)2.49712717
144response to interferon-beta (GO:0035456)2.49252215
145electron transport chain (GO:0022900)2.48927088
146peptidyl-arginine methylation (GO:0018216)2.48774916
147peptidyl-arginine N-methylation (GO:0035246)2.48774916
148response to misfolded protein (GO:0051788)2.48724652
149B cell mediated immunity (GO:0019724)2.48497114
150cellular protein complex disassembly (GO:0043624)2.48290178
151ribosome biogenesis (GO:0042254)2.48003123
152retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.46594094
153L-serine metabolic process (GO:0006563)2.46278080
154heme metabolic process (GO:0042168)2.46246806
155NADP metabolic process (GO:0006739)2.44854586
156NADPH regeneration (GO:0006740)2.44282382
157fibril organization (GO:0097435)2.43721926
158negative thymic T cell selection (GO:0045060)2.43420086
159endosome to pigment granule transport (GO:0043485)2.42697732
160endosome to melanosome transport (GO:0035646)2.42697732
161pinocytosis (GO:0006907)2.41745256
162NIK/NF-kappaB signaling (GO:0038061)2.41534266
163actin nucleation (GO:0045010)2.41082880
164galactose metabolic process (GO:0006012)2.39952472
165IMP metabolic process (GO:0046040)2.37291279
166negative regulation of ligase activity (GO:0051352)2.36764180
167negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.36764180
168protein maturation by protein folding (GO:0022417)2.35966174
169response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.32135434
170response to host (GO:0075136)2.32135434
171response to host defenses (GO:0052200)2.32135434
172keratan sulfate catabolic process (GO:0042340)2.30101307
173DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.29755313
174antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.29436877
175de novo posttranslational protein folding (GO:0051084)2.29436079
176trabecula morphogenesis (GO:0061383)2.28383548
177regulation of chemokine biosynthetic process (GO:0045073)2.27390955
178histone arginine methylation (GO:0034969)2.27085166
179intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.26513902
180signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.26513902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.13014569
2E2F7_22180533_ChIP-Seq_HELA_Human3.09614693
3EGR1_19374776_ChIP-ChIP_THP-1_Human2.92101795
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90758380
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.57089798
6MYC_22102868_ChIP-Seq_BL_Human2.47587529
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24048866
8ZNF263_19887448_ChIP-Seq_K562_Human2.21096062
9VDR_21846776_ChIP-Seq_THP-1_Human2.20797627
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20018650
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.19549920
12* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18650209
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15461554
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99483593
15CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.98263306
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98037401
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96324235
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.86131112
19IRF8_21731497_ChIP-ChIP_J774_Mouse1.83586755
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82305824
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.79882880
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76626496
23* XRN2_22483619_ChIP-Seq_HELA_Human1.75426369
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74589458
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73241167
26GABP_19822575_ChIP-Seq_HepG2_Human1.70442183
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69777041
28SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.69494138
29LXR_22292898_ChIP-Seq_THP-1_Human1.67944719
30CIITA_25753668_ChIP-Seq_RAJI_Human1.67453271
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65769644
32TFEB_21752829_ChIP-Seq_HELA_Human1.61763321
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59760086
34* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59690693
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.59041821
36RACK7_27058665_Chip-Seq_MCF-7_Human1.58456226
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.58038900
38DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.56704293
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56215791
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56018928
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.55882657
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55395260
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53960373
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53716740
45KDM5A_27292631_Chip-Seq_BREAST_Human1.53645945
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52839650
47* SPI1_23547873_ChIP-Seq_NB4_Human1.51582957
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50619593
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50482312
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49871916
51* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49258519
52MAF_26560356_Chip-Seq_TH1_Human1.46973831
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.46475203
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44780122
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44222728
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39185611
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38721852
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38710433
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.38390161
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.37236877
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37046758
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35495044
63MYB_26560356_Chip-Seq_TH2_Human1.34725664
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34357703
65* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34231628
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33845874
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33175762
68NCOR1_26117541_ChIP-Seq_K562_Human1.33091634
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32747900
70* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30300190
71VDR_23849224_ChIP-Seq_CD4+_Human1.30287573
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30073974
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30055709
74VDR_24763502_ChIP-Seq_THP-1_Human1.29756072
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28457724
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27604514
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27458161
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27160652
79* P68_20966046_ChIP-Seq_HELA_Human1.24964765
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24954222
81DCP1A_22483619_ChIP-Seq_HELA_Human1.24392625
82UTX_26944678_Chip-Seq_JUKART_Human1.24301718
83* BCL6_27268052_Chip-Seq_Bcells_Human1.24279233
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.24174850
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21748618
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21511952
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20285766
88FOXP3_21729870_ChIP-Seq_TREG_Human1.20205847
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20030107
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19743162
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18466291
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17662021
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16825900
94NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15494686
95CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15238360
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13742908
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12925871
98YY1_21170310_ChIP-Seq_MESCs_Mouse1.12564793
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11455671
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10183721
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09979653
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.09627893
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09459121
104HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09016749
105YY1_22570637_ChIP-Seq_MALME-3M_Human1.08421068
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07130687
107FOXP1_21924763_ChIP-Seq_HESCs_Human1.06421197
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06363408
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05890012
110TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05585063
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05538939
112CLOCK_20551151_ChIP-Seq_293T_Human1.04644694
113ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04638004
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03610074
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02843897
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02507520
117ATF3_27146783_Chip-Seq_COLON_Human1.02240141
118SPI1_23127762_ChIP-Seq_K562_Human1.02069200
119TTF2_22483619_ChIP-Seq_HELA_Human1.02035501
120* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01983204
121* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01896754
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01616722
123BCOR_27268052_Chip-Seq_Bcells_Human1.01488790
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00946933
125BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00937459
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00929774
127MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00829786
128TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.00690311
129MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99652947
130FOXM1_23109430_ChIP-Seq_U2OS_Human0.99532163
131PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98415994
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96288574
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96060088

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003172_abnormal_lysosome_physiology3.88975185
2MP0005451_abnormal_body_composition3.67818916
3MP0005058_abnormal_lysosome_morphology3.63731811
4MP0008438_abnormal_cutaneous_collagen3.49484534
5MP0004858_abnormal_nervous_system3.16806819
6MP0003279_aneurysm2.78322087
7MP0009384_cardiac_valve_regurgitation2.62155838
8MP0003111_abnormal_nucleus_morphology2.58604815
9MP0002089_abnormal_postnatal_growth/wei2.45454658
10MP0006054_spinal_hemorrhage2.43884428
11MP0003183_abnormal_peptide_metabolism2.43827438
12MP0000678_abnormal_parathyroid_gland2.36758274
13MP0003329_amyloid_beta_deposits2.33429607
14MP0003806_abnormal_nucleotide_metabolis2.22520778
15MP0006082_CNS_inflammation2.19896040
16MP0009333_abnormal_splenocyte_physiolog2.11416430
17MP0002653_abnormal_ependyma_morphology2.10871342
18MP0000685_abnormal_immune_system2.09708521
19MP0003786_premature_aging2.08625421
20MP0002877_abnormal_melanocyte_morpholog2.03730473
21MP0000537_abnormal_urethra_morphology1.94384711
22MP0005408_hypopigmentation1.92963241
23MP0005083_abnormal_biliary_tract1.89839636
24MP0005671_abnormal_response_to1.88203223
25MP0001835_abnormal_antigen_presentation1.81930340
26MP0003283_abnormal_digestive_organ1.81229829
27MP0003763_abnormal_thymus_physiology1.80883695
28MP0001661_extended_life_span1.80042934
29MP0006036_abnormal_mitochondrial_physio1.79384940
30MP0005503_abnormal_tendon_morphology1.78836724
31MP0002132_abnormal_respiratory_system1.77641396
32MP0009840_abnormal_foam_cell1.76659190
33MP0001958_emphysema1.72343137
34MP0003705_abnormal_hypodermis_morpholog1.69661678
35MP0001853_heart_inflammation1.66220539
36MP0003315_abnormal_perineum_morphology1.64693903
37MP0008260_abnormal_autophagy1.63407364
38MP0003075_altered_response_to1.62410166
39MP0000604_amyloidosis1.61504096
40MP0003690_abnormal_glial_cell1.59732025
41MP0002419_abnormal_innate_immunity1.57849438
42MP0003191_abnormal_cellular_cholesterol1.57543264
43MP0010030_abnormal_orbit_morphology1.53541124
44MP0005360_urolithiasis1.51085680
45MP0000372_irregular_coat_pigmentation1.47849797
46MP0003186_abnormal_redox_activity1.46799118
47MP0003436_decreased_susceptibility_to1.46024502
48MP0009785_altered_susceptibility_to1.43590410
49MP0000858_altered_metastatic_potential1.43496668
50MP0002452_abnormal_antigen_presenting1.43027105
51MP0002933_joint_inflammation1.42485029
52MP0005423_abnormal_somatic_nervous1.42411484
53MP0001533_abnormal_skeleton_physiology1.42243527
54MP0002405_respiratory_system_inflammati1.42052987
55MP0005000_abnormal_immune_tolerance1.41748965
56MP0008007_abnormal_cellular_replicative1.39938243
57MP0002420_abnormal_adaptive_immunity1.37220803
58MP0000343_altered_response_to1.35639627
59MP0001819_abnormal_immune_cell1.35218517
60MP0005501_abnormal_skin_physiology1.34992550
61MP0000681_abnormal_thyroid_gland1.34029571
62MP0003634_abnormal_glial_cell1.31394213
63MP0000516_abnormal_urinary_system1.30575870
64MP0005367_renal/urinary_system_phenotyp1.30575870
65MP0005023_abnormal_wound_healing1.28970127
66MP0004264_abnormal_extraembryonic_tissu1.28675961
67MP0002398_abnormal_bone_marrow1.27053953
68MP0003122_maternal_imprinting1.26998970
69MP0005025_abnormal_response_to1.26478000
70MP0008058_abnormal_DNA_repair1.25315501
71MP0002396_abnormal_hematopoietic_system1.24109633
72MP0001800_abnormal_humoral_immune1.22279840
73MP0010094_abnormal_chromosome_stability1.22240826
74MP0004185_abnormal_adipocyte_glucose1.21250328
75MP0002723_abnormal_immune_serum1.21126433
76MP0005387_immune_system_phenotype1.20425420
77MP0001790_abnormal_immune_system1.20425420
78MP0001730_embryonic_growth_arrest1.19317232
79MP0000490_abnormal_crypts_of1.19303311
80MP0004233_abnormal_muscle_weight1.18614571
81MP0000313_abnormal_cell_death1.18500495
82MP0001881_abnormal_mammary_gland1.18228669
83MP0000689_abnormal_spleen_morphology1.17747454
84MP0002148_abnormal_hypersensitivity_rea1.15613043
85MP0000428_abnormal_craniofacial_morphol1.14752067
86MP0005390_skeleton_phenotype1.14044235
87MP0002722_abnormal_immune_system1.13298846
88MP0005584_abnormal_enzyme/coenzyme_acti1.13026394
89MP0000015_abnormal_ear_pigmentation1.11468236
90MP0003300_gastrointestinal_ulcer1.10870171
91MP0009278_abnormal_bone_marrow1.10795771
92MP0000003_abnormal_adipose_tissue1.10184391
93MP0005076_abnormal_cell_differentiation1.10113629
94MP0006035_abnormal_mitochondrial_morpho1.09885228
95MP0004147_increased_porphyrin_level1.08275557
96MP0004134_abnormal_chest_morphology1.08031943
97MP0001764_abnormal_homeostasis1.06312215
98MP0001727_abnormal_embryo_implantation1.05862473
99MP0005508_abnormal_skeleton_morphology1.05778016
100MP0000716_abnormal_immune_system1.05763817
101MP0002080_prenatal_lethality1.05733276
102MP0001986_abnormal_taste_sensitivity1.04882129
103MP0009780_abnormal_chondrocyte_physiolo1.04775997
104MP0005464_abnormal_platelet_physiology1.03960943
105MP0005330_cardiomyopathy1.02675677
106MP0002429_abnormal_blood_cell1.01402722
107MP0000750_abnormal_muscle_regeneration1.01220929
108MP0000358_abnormal_cell_content/1.01048299
109MP0001542_abnormal_bone_strength1.00746741
110MP0000049_abnormal_middle_ear0.98186166
111MP0003123_paternal_imprinting0.97916190
112MP0005075_abnormal_melanosome_morpholog0.97812230
113MP0003693_abnormal_embryo_hatching0.96961783
114MP0003566_abnormal_cell_adhesion0.96668296
115MP0005623_abnormal_meninges_morphology0.96394597
116MP0008995_early_reproductive_senescence0.95066825
117MP0000350_abnormal_cell_proliferation0.93388613
118MP0010307_abnormal_tumor_latency0.93130019
119MP0003448_altered_tumor_morphology0.93027471
120MP0005253_abnormal_eye_physiology0.90925259
121MP0004957_abnormal_blastocyst_morpholog0.90480680
122MP0000747_muscle_weakness0.89961985
123MP0003984_embryonic_growth_retardation0.88827030
124MP0004782_abnormal_surfactant_physiolog0.88081761
125MP0001697_abnormal_embryo_size0.88024195
126MP0005397_hematopoietic_system_phenotyp0.87625871
127MP0001545_abnormal_hematopoietic_system0.87625871
128MP0009643_abnormal_urine_homeostasis0.87586137
129MP0002090_abnormal_vision0.87047797
130MP0000534_abnormal_ureter_morphology0.86378978
131MP0000538_abnormal_urinary_bladder0.86040444
132MP0003878_abnormal_ear_physiology0.85948573
133MP0005377_hearing/vestibular/ear_phenot0.85948573
134MP0000703_abnormal_thymus_morphology0.85758124
135MP0002269_muscular_atrophy0.85626862
136MP0000609_abnormal_liver_physiology0.84819412
137MP0005166_decreased_susceptibility_to0.84341314
138MP0004808_abnormal_hematopoietic_stem0.83649366
139MP0010352_gastrointestinal_tract_polyps0.83201173
140MP0003077_abnormal_cell_cycle0.82551623
141MP0001672_abnormal_embryogenesis/_devel0.81522713
142MP0005380_embryogenesis_phenotype0.81522713
143MP0003942_abnormal_urinary_system0.80646777
144MP0004272_abnormal_basement_membrane0.80326680
145MP0005384_cellular_phenotype0.79388305
146MP0002088_abnormal_embryonic_growth/wei0.79316554
147MP0005636_abnormal_mineral_homeostasis0.78887383
148MP0001845_abnormal_inflammatory_respons0.78474528
149MP0002970_abnormal_white_adipose0.78409058
150MP0009672_abnormal_birth_weight0.77550251
151MP0005275_abnormal_skin_tensile0.76954351
152MP0009931_abnormal_skin_appearance0.76224734
153MP0009379_abnormal_foot_pigmentation0.76190991
154MP0003656_abnormal_erythrocyte_physiolo0.75876350
155MP0005646_abnormal_pituitary_gland0.75729413
156MP0001186_pigmentation_phenotype0.75728178
157MP0003950_abnormal_plasma_membrane0.75608040
158MP0002166_altered_tumor_susceptibility0.75028715
159MP0002751_abnormal_autonomic_nervous0.74763766
160MP0000759_abnormal_skeletal_muscle0.74596866
161MP0002075_abnormal_coat/hair_pigmentati0.74222233
162MP0003115_abnormal_respiratory_system0.73491462
163MP0005621_abnormal_cell_physiology0.72859608
164MP0000598_abnormal_liver_morphology0.72816806
165MP0001915_intracranial_hemorrhage0.72331982
166MP0008932_abnormal_embryonic_tissue0.71487271
167MP0002019_abnormal_tumor_incidence0.70938718
168MP0004947_skin_inflammation0.70305273
169MP0002998_abnormal_bone_remodeling0.69584806
170MP0002822_catalepsy0.69009496
171MP0002295_abnormal_pulmonary_circulatio0.67856133
172MP0003866_abnormal_defecation0.66997854

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)5.19970925
2Abnormal gallbladder physiology (HP:0012438)5.19970925
3Abnormality of glycolysis (HP:0004366)4.50079233
4Vertebral compression fractures (HP:0002953)4.33028754
5Dysostosis multiplex (HP:0000943)4.30788673
6Protrusio acetabuli (HP:0003179)4.29016089
7Cervical subluxation (HP:0003308)3.92030861
8Increased cerebral lipofuscin (HP:0011813)3.84890089
9Increased neuronal autofluorescent lipopigment (HP:0002074)3.72480116
10Increased serum pyruvate (HP:0003542)3.65504916
11Abnormality of glycolipid metabolism (HP:0010969)3.65478670
12Abnormality of liposaccharide metabolism (HP:0010968)3.65478670
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.65478670
14Mucopolysacchariduria (HP:0008155)3.46413203
15Urinary glycosaminoglycan excretion (HP:0003541)3.46413203
16Selective tooth agenesis (HP:0001592)3.26811965
17Abnormality of mucopolysaccharide metabolism (HP:0011020)3.25749970
18Abnormality of polysaccharide metabolism (HP:0011012)3.25749970
19Abnormality of glycosaminoglycan metabolism (HP:0004371)3.25749970
20Ragged-red muscle fibers (HP:0003200)3.16643905
21Hypertensive crisis (HP:0100735)3.11936710
22Progressive neurologic deterioration (HP:0002344)3.11698093
23Truncus arteriosus (HP:0001660)3.05292655
24Hyperthyroidism (HP:0000836)3.03204825
25Joint stiffness (HP:0001387)3.01536333
26Reticulocytosis (HP:0001923)2.96526152
27Testicular atrophy (HP:0000029)2.94175305
28Cholelithiasis (HP:0001081)2.89018676
29Elevated erythrocyte sedimentation rate (HP:0003565)2.88987070
30Recurrent abscess formation (HP:0002722)2.86545921
31Megalencephaly (HP:0001355)2.77233738
32Biconcave vertebral bodies (HP:0004586)2.76921196
33IgM deficiency (HP:0002850)2.72641943
34Abnormality of reticulocytes (HP:0004312)2.70061940
35Abnormal mitochondria in muscle tissue (HP:0008316)2.68622658
36Hypokinesia (HP:0002375)2.68221513
37Abnormal gallbladder morphology (HP:0012437)2.55242899
38Vacuolated lymphocytes (HP:0001922)2.51504076
39Hyperammonemia (HP:0001987)2.51246552
40Myopathic facies (HP:0002058)2.50216026
41Abnormality of the distal phalanges of the toes (HP:0010182)2.48731451
42Type I transferrin isoform profile (HP:0003642)2.47980917
43Increased muscle lipid content (HP:0009058)2.47090694
44Abnormality of the tricuspid valve (HP:0001702)2.45456657
45Diminished motivation (HP:0000745)2.44345215
46Abnormality of the gallbladder (HP:0005264)2.44173002
47Atelectasis (HP:0100750)2.40831369
48J-shaped sella turcica (HP:0002680)2.40692481
49Progressive muscle weakness (HP:0003323)2.40007843
50Broad face (HP:0000283)2.39810845
51Premature rupture of membranes (HP:0001788)2.39282934
52Hand muscle atrophy (HP:0009130)2.37382693
53Hepatic necrosis (HP:0002605)2.35669632
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30591786
55Diplopia (HP:0000651)2.28916190
56Abnormality of binocular vision (HP:0011514)2.28916190
57Seborrheic dermatitis (HP:0001051)2.27721216
58Deformed sella turcica (HP:0002681)2.27485121
59Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.26271534
60Loss of speech (HP:0002371)2.26060307
61Entropion (HP:0000621)2.25156758
62Hepatocellular necrosis (HP:0001404)2.21561011
63Poor head control (HP:0002421)2.21512638
64Interstitial pulmonary disease (HP:0006530)2.20968188
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20540506
66Abnormal protein N-linked glycosylation (HP:0012347)2.20540506
67Abnormal protein glycosylation (HP:0012346)2.20540506
68Abnormal glycosylation (HP:0012345)2.20540506
69Ileus (HP:0002595)2.17470900
70Microretrognathia (HP:0000308)2.16823506
71Supranuclear gaze palsy (HP:0000605)2.16068919
72Mesangial abnormality (HP:0001966)2.14321439
73Reticulocytopenia (HP:0001896)2.14193049
74Increased intramyocellular lipid droplets (HP:0012240)2.12840240
75Hypoparathyroidism (HP:0000829)2.11505586
76Acute necrotizing encephalopathy (HP:0006965)2.11439472
77Ankle contracture (HP:0006466)2.10353507
78Increased CSF lactate (HP:0002490)2.09171368
79Myoglobinuria (HP:0002913)2.08504669
80Neurofibrillary tangles (HP:0002185)2.07784324
81Secondary amenorrhea (HP:0000869)2.05078768
82Cerebral hypomyelination (HP:0006808)2.04444670
83Abnormal umbilical cord blood vessels (HP:0011403)2.04346957
84Single umbilical artery (HP:0001195)2.04346957
85Abnormality of the fetal cardiovascular system (HP:0010948)2.04346957
86Aplasia involving bones of the upper limbs (HP:0009823)2.04260950
87Aplasia of the phalanges of the hand (HP:0009802)2.04260950
88Aplasia involving bones of the extremities (HP:0009825)2.04260950
89Mitochondrial inheritance (HP:0001427)2.03672206
90Petechiae (HP:0000967)2.02889254
91Septate vagina (HP:0001153)2.02810850
92Mediastinal lymphadenopathy (HP:0100721)2.02397837
93Acute encephalopathy (HP:0006846)2.01841703
94Apathy (HP:0000741)2.01108734
95Short nail (HP:0001799)2.00950574
96Hypoplasia of the odontoid process (HP:0003311)2.00201230
97Growth hormone excess (HP:0000845)1.99599115
98Abnormality of macrophages (HP:0004311)1.99485576
99Abnormality of the umbilical cord (HP:0010881)1.98356855
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.97957552
101Gastrointestinal dysmotility (HP:0002579)1.96501036
102Degeneration of anterior horn cells (HP:0002398)1.96418786
103Abnormality of the anterior horn cell (HP:0006802)1.96418786
104Orthostatic hypotension (HP:0001278)1.96304044
105Eczematoid dermatitis (HP:0000976)1.94891835
106Short middle phalanx of the 5th finger (HP:0004220)1.94417448
107Personality changes (HP:0000751)1.93293402
108Spinal canal stenosis (HP:0003416)1.92780379
109Exercise intolerance (HP:0003546)1.92362270
110Ulnar bowing (HP:0003031)1.90675544
111Rhabdomyolysis (HP:0003201)1.89831145
112Emphysema (HP:0002097)1.89248466
113Beaking of vertebral bodies (HP:0004568)1.89025874
114Gout (HP:0001997)1.88913659
115Thrombocytosis (HP:0001894)1.88841757
116Nausea (HP:0002018)1.88398096
117Trismus (HP:0000211)1.88191395
118Emotional lability (HP:0000712)1.87164862
119Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.87143906
120Albinism (HP:0001022)1.86216886
121Hyperacusis (HP:0010780)1.86181076
122Lactic acidosis (HP:0003128)1.86047399
123Nonimmune hydrops fetalis (HP:0001790)1.85225130
124Purpura (HP:0000979)1.85075189
125Stridor (HP:0010307)1.85058421
126Premature ovarian failure (HP:0008209)1.84763853
127Basal ganglia calcification (HP:0002135)1.84389352
128Increased serum ferritin (HP:0003281)1.83718691
129Fatigue (HP:0012378)1.83636370
130Disproportionate tall stature (HP:0001519)1.83409523
131Abnormality of the acetabulum (HP:0003170)1.82730132
132Aplastic anemia (HP:0001915)1.82576070
133Abnormality of the lumbar spine (HP:0100712)1.82472307
134Cardiomegaly (HP:0001640)1.82351863
135Spastic paraparesis (HP:0002313)1.82184950
136Myositis (HP:0100614)1.81358116
137Cerebral aneurysm (HP:0004944)1.81248236
138Recurrent bronchitis (HP:0002837)1.80797690
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80286275
140Premature skin wrinkling (HP:0100678)1.79580039
141Broad distal phalanx of finger (HP:0009836)1.79169471
142Abnormality of dentin (HP:0010299)1.79013349
143Muscle stiffness (HP:0003552)1.78091606
144Gastrointestinal stroma tumor (HP:0100723)1.77704811
145Recurrent bacterial skin infections (HP:0005406)1.77595123
146Opisthotonus (HP:0002179)1.77283567
147Chronic otitis media (HP:0000389)1.76993891
148Increased serum lactate (HP:0002151)1.76741635
149Neuroendocrine neoplasm (HP:0100634)1.75675219
150Lymphopenia (HP:0001888)1.74535771
151Flared iliac wings (HP:0002869)1.74303513
152Breech presentation (HP:0001623)1.73829580
153Soft skin (HP:0000977)1.73600493
154Aortic dissection (HP:0002647)1.73452868
155Abnormality of cells of the lymphoid lineage (HP:0012140)1.73189083
156Generalized amyotrophy (HP:0003700)1.72884989
157Spondylolisthesis (HP:0003302)1.72662253
158Arterial tortuosity (HP:0005116)1.71898983
159Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.71465344
160Vertebral hypoplasia (HP:0008417)1.71465344
161Abnormality of the odontoid process (HP:0003310)1.71448658
162Atrophy/Degeneration involving motor neurons (HP:0007373)1.71219519
163Urticaria (HP:0001025)1.70712548
164Vascular tortuosity (HP:0004948)1.69245955
165Hepatosplenomegaly (HP:0001433)1.68966128
166Upper limb amyotrophy (HP:0009129)1.68962191
167Distal upper limb amyotrophy (HP:0007149)1.68962191
168Broad metatarsal (HP:0001783)1.66014090
169Broad alveolar ridges (HP:0000187)1.65616046
170Disproportionate short-trunk short stature (HP:0003521)1.65521020
171Wrist flexion contracture (HP:0001239)1.64532578
172Abnormality of skull ossification (HP:0002703)1.63780836
173Aortic aneurysm (HP:0004942)1.63153755
174Neonatal short-limb short stature (HP:0008921)1.62953689
175Agnosia (HP:0010524)1.62591803
176Bladder diverticulum (HP:0000015)1.62400834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.95068026
2ERN13.61295034
3PIM23.56917321
4SMG13.43359028
5TESK23.10041015
6MAP4K12.95034039
7TRIB32.89728857
8IRAK32.55584305
9KIT2.49942206
10VRK22.46153648
11TBK12.28318621
12SCYL22.25937166
13LMTK22.23341078
14TESK12.18705116
15ZAP702.16020045
16EIF2AK12.14705197
17EPHA31.99112216
18EEF2K1.83193388
19STK161.72457392
20TAOK21.66656496
21JAK31.59207964
22PKN21.58632052
23CDK121.54431725
24LRRK21.53363631
25MAP3K101.53307279
26KDR1.51752250
27STK101.51675709
28MAP3K111.51147484
29BTK1.48422398
30CAMK1D1.47342996
31WEE11.41309750
32FLT31.40944310
33EPHA21.36553208
34EPHB11.34363029
35TYK21.32942475
36LIMK11.31893976
37PAK41.27237655
38MATK1.25172935
39RPS6KA41.23590852
40CSF1R1.22996044
41PRKD21.22329144
42STK241.21377703
43NEK11.18533575
44NME21.16239250
45ARAF1.15031391
46BLK1.14490802
47PDK21.12929215
48IRAK41.10313063
49KSR21.05073225
50FGFR41.03060145
51FGFR11.01425631
52RIPK41.00072890
53GRK60.99565776
54MAP3K30.97467979
55SRPK10.95891785
56ILK0.94984837
57MAP3K80.92085099
58PHKG10.88830464
59PHKG20.88830464
60TNIK0.88468189
61MAPKAPK30.88388615
62CDK80.88062103
63SIK10.87153895
64DYRK1B0.85915146
65IKBKE0.85866688
66RPS6KB20.85009470
67RAF10.84705054
68CAMK1G0.82278920
69STK30.80061904
70CLK10.79836158
71TXK0.78709614
72CDK70.78509957
73SYK0.78037473
74MAP3K120.77415471
75LYN0.76095178
76PASK0.75467143
77MAP3K130.74160373
78ICK0.73424294
79MAPK110.72410013
80PAK10.70999862
81AKT20.70834899
82NTRK20.70178411
83TNK20.68118260
84MAPK150.68114929
85TAOK10.67068188
86CHEK20.65919261
87PDPK10.65852270
88RIPK10.64937631
89LCK0.64785395
90PRKD30.64014176
91MST1R0.63621720
92MTOR0.62935187
93NTRK10.62164579
94HCK0.62012839
95SIK30.59911700
96IRAK20.59055302
97AURKB0.58239010
98TGFBR20.57904969
99BRSK10.56019725
100EIF2AK30.54980192
101RPS6KA20.54532358
102DDR20.54361362
103CDC70.53579258
104TSSK60.53554710
105TTK0.53119654
106HIPK20.52137483
107MAP2K20.51401218
108CDK40.49899365
109EPHB20.49498910
110DAPK10.49128256
111IRAK10.48226372
112PRKCD0.45846415
113MAPKAPK50.45374444
114ROCK20.45319130
115ABL20.44782049
116ATR0.44546676
117PTK60.44061818
118NEK20.43797066
119BCKDK0.43689808
120NME10.43648305
121MAP4K20.43507578
122CDK140.43416444
123DYRK30.43356037
124ITK0.42549328
125AURKA0.41842907
126CSNK1G30.41617579
127CSK0.41424703
128TEC0.41112770
129CHEK10.40844209
130MAPKAPK20.40774397
131RPS6KC10.40644961
132RPS6KL10.40644961
133PRPF4B0.40402262
134DAPK30.40104307
135MUSK0.39867840
136CDK190.39364192
137MOS0.38026832
138PAK60.37805283
139MAP3K10.37496541
140PRKG20.36530403
141ACVR1B0.36314659
142MAP2K30.35481862
143CAMKK20.34677003
144TGFBR10.34561027
145CCNB10.33679578
146PDK10.31880049
147CSNK2A20.31198343

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysosome_Homo sapiens_hsa041422.96742344
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.96424006
3DNA replication_Homo sapiens_hsa030302.91918069
4Proteasome_Homo sapiens_hsa030502.63585206
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.58124704
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.50077957
7Other glycan degradation_Homo sapiens_hsa005112.47052455
8Sulfur relay system_Homo sapiens_hsa041222.36136382
9Fatty acid elongation_Homo sapiens_hsa000622.34853530
10N-Glycan biosynthesis_Homo sapiens_hsa005102.28446060
11Oxidative phosphorylation_Homo sapiens_hsa001901.92903146
12Base excision repair_Homo sapiens_hsa034101.89559132
13Mismatch repair_Homo sapiens_hsa034301.87132410
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86494444
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.78650386
16Antigen processing and presentation_Homo sapiens_hsa046121.78462437
17Parkinsons disease_Homo sapiens_hsa050121.75555365
18RNA polymerase_Homo sapiens_hsa030201.68074931
19Shigellosis_Homo sapiens_hsa051311.67504637
20One carbon pool by folate_Homo sapiens_hsa006701.62887010
21Pyruvate metabolism_Homo sapiens_hsa006201.56690563
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55982857
23Leishmaniasis_Homo sapiens_hsa051401.55068372
24Primary immunodeficiency_Homo sapiens_hsa053401.52573711
25Pentose phosphate pathway_Homo sapiens_hsa000301.51731630
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48539243
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44751901
28Glutathione metabolism_Homo sapiens_hsa004801.44197640
29* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41239049
30Fatty acid metabolism_Homo sapiens_hsa012121.37038016
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36240104
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33422082
33Malaria_Homo sapiens_hsa051441.32272114
34Folate biosynthesis_Homo sapiens_hsa007901.31856327
35Huntingtons disease_Homo sapiens_hsa050161.31424412
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30563255
37Viral myocarditis_Homo sapiens_hsa054161.28926646
38Legionellosis_Homo sapiens_hsa051341.24303210
39Pyrimidine metabolism_Homo sapiens_hsa002401.24140734
40Nucleotide excision repair_Homo sapiens_hsa034201.22653905
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21786138
42Cell cycle_Homo sapiens_hsa041101.20512924
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19025519
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18239386
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17322893
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15042225
47Galactose metabolism_Homo sapiens_hsa000521.15031461
48Phagosome_Homo sapiens_hsa041451.14356637
49Apoptosis_Homo sapiens_hsa042101.13705204
50Homologous recombination_Homo sapiens_hsa034401.11584241
51Hematopoietic cell lineage_Homo sapiens_hsa046401.10174965
52Protein export_Homo sapiens_hsa030601.10029038
53Steroid biosynthesis_Homo sapiens_hsa001001.09200152
54Colorectal cancer_Homo sapiens_hsa052101.07494748
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06599829
56Bladder cancer_Homo sapiens_hsa052191.06416508
57Epstein-Barr virus infection_Homo sapiens_hsa051691.06138683
58Vibrio cholerae infection_Homo sapiens_hsa051101.02988811
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02211792
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02154656
61Spliceosome_Homo sapiens_hsa030401.01367615
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99343629
63Measles_Homo sapiens_hsa051620.98090036
64Alzheimers disease_Homo sapiens_hsa050100.95394348
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.92575020
66Hepatitis B_Homo sapiens_hsa051610.92560850
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.91942802
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90896413
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90500572
70B cell receptor signaling pathway_Homo sapiens_hsa046620.89806912
71p53 signaling pathway_Homo sapiens_hsa041150.87298327
72Tuberculosis_Homo sapiens_hsa051520.86996515
73Toxoplasmosis_Homo sapiens_hsa051450.86362224
74RNA transport_Homo sapiens_hsa030130.85204984
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83989393
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83985625
77HTLV-I infection_Homo sapiens_hsa051660.82868537
78Pancreatic cancer_Homo sapiens_hsa052120.82280838
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79749711
80Sphingolipid metabolism_Homo sapiens_hsa006000.79488867
81Biosynthesis of amino acids_Homo sapiens_hsa012300.79431686
82Fatty acid biosynthesis_Homo sapiens_hsa000610.78007608
83Sulfur metabolism_Homo sapiens_hsa009200.76291664
84Endocytosis_Homo sapiens_hsa041440.75770573
85Pertussis_Homo sapiens_hsa051330.75754998
86Fructose and mannose metabolism_Homo sapiens_hsa000510.75689840
87Herpes simplex infection_Homo sapiens_hsa051680.74834401
88Osteoclast differentiation_Homo sapiens_hsa043800.74324930
89Chronic myeloid leukemia_Homo sapiens_hsa052200.73886028
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72926891
91Salmonella infection_Homo sapiens_hsa051320.72134671
92Notch signaling pathway_Homo sapiens_hsa043300.71199241
93Lysine degradation_Homo sapiens_hsa003100.70090925
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68864941
95Arginine and proline metabolism_Homo sapiens_hsa003300.68308308
96Acute myeloid leukemia_Homo sapiens_hsa052210.68105656
97* Metabolic pathways_Homo sapiens_hsa011000.67916053
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.67759613
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65988325
100Proteoglycans in cancer_Homo sapiens_hsa052050.65562202
101Purine metabolism_Homo sapiens_hsa002300.63926885
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63679163
103Renin-angiotensin system_Homo sapiens_hsa046140.63041695
104T cell receptor signaling pathway_Homo sapiens_hsa046600.62284568
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.60639781
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59372661
107Viral carcinogenesis_Homo sapiens_hsa052030.58569774
108Hippo signaling pathway_Homo sapiens_hsa043900.58318833
109Basal cell carcinoma_Homo sapiens_hsa052170.58158057
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57225192
111Influenza A_Homo sapiens_hsa051640.52398651
112Non-small cell lung cancer_Homo sapiens_hsa052230.51850755
113HIF-1 signaling pathway_Homo sapiens_hsa040660.51735144
114Vitamin digestion and absorption_Homo sapiens_hsa049770.51686442
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.51354657
116Graft-versus-host disease_Homo sapiens_hsa053320.50894231
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50473868
118Rheumatoid arthritis_Homo sapiens_hsa053230.49119544
119Synaptic vesicle cycle_Homo sapiens_hsa047210.48612489
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48369732
121Hedgehog signaling pathway_Homo sapiens_hsa043400.47982214
122Small cell lung cancer_Homo sapiens_hsa052220.47228798
123AMPK signaling pathway_Homo sapiens_hsa041520.46361378
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.42194644
125Mineral absorption_Homo sapiens_hsa049780.40635454
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40554939
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.40322618
128Ribosome_Homo sapiens_hsa030100.38476915
129Pathways in cancer_Homo sapiens_hsa052000.36835754
130Carbon metabolism_Homo sapiens_hsa012000.36606191
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36182260
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35930800
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35873487
134Insulin signaling pathway_Homo sapiens_hsa049100.35368119
135Peroxisome_Homo sapiens_hsa041460.32201844
136Thyroid cancer_Homo sapiens_hsa052160.30968280
137Collecting duct acid secretion_Homo sapiens_hsa049660.30736933
138Non-homologous end-joining_Homo sapiens_hsa034500.28711243
139Fanconi anemia pathway_Homo sapiens_hsa034600.27980972
140mTOR signaling pathway_Homo sapiens_hsa041500.26174614
141Arginine biosynthesis_Homo sapiens_hsa002200.24627325
142Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23830775
143Fat digestion and absorption_Homo sapiens_hsa049750.20481135
144Fatty acid degradation_Homo sapiens_hsa000710.19572540
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.18202363
146Propanoate metabolism_Homo sapiens_hsa006400.18077499
147Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17366771

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