PIGT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.97690622
2sodium ion export (GO:0071436)4.46317743
3negative regulation of cell size (GO:0045792)4.03096696
4regulation of cholesterol homeostasis (GO:2000188)3.97703422
5amyloid precursor protein catabolic process (GO:0042987)3.95980162
6positive regulation of histone deacetylation (GO:0031065)3.92728602
7endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.85997495
8proline biosynthetic process (GO:0006561)3.82743496
9Golgi transport vesicle coating (GO:0048200)3.77560705
10COPI coating of Golgi vesicle (GO:0048205)3.77560705
11alpha-linolenic acid metabolic process (GO:0036109)3.64486711
12regulation of metalloenzyme activity (GO:0048552)3.59771543
13NADH metabolic process (GO:0006734)3.58721529
14cytoskeletal anchoring at plasma membrane (GO:0007016)3.54119062
15GDP-mannose metabolic process (GO:0019673)3.51850075
16regulation of fatty acid beta-oxidation (GO:0031998)3.39570084
17activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.32615276
18apoptotic cell clearance (GO:0043277)3.32274295
19mannose metabolic process (GO:0006013)3.29742650
20COPII vesicle coating (GO:0048208)3.28521379
21regulation of extracellular matrix disassembly (GO:0010715)3.28030232
22L-phenylalanine metabolic process (GO:0006558)3.24942965
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.24942965
24regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.24803319
25desmosome organization (GO:0002934)3.23543362
26positive regulation of nuclease activity (GO:0032075)3.20452797
27epithelial cell differentiation involved in prostate gland development (GO:0060742)3.19213274
28peptidyl-lysine dimethylation (GO:0018027)3.16818253
29regulation of translational fidelity (GO:0006450)3.16665306
30protein retention in ER lumen (GO:0006621)3.16305243
31maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.12281741
32type B pancreatic cell proliferation (GO:0044342)3.11580903
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.10675153
34pentose-phosphate shunt (GO:0006098)3.09382619
35lipopolysaccharide biosynthetic process (GO:0009103)3.08944844
36amyloid precursor protein metabolic process (GO:0042982)3.08442286
37regulation of NFAT protein import into nucleus (GO:0051532)3.07013605
38mitotic nuclear envelope reassembly (GO:0007084)3.05246295
39nuclear envelope reassembly (GO:0031468)3.05246295
40regulation of podosome assembly (GO:0071801)2.96016791
41positive regulation of triglyceride biosynthetic process (GO:0010867)2.94501940
424-hydroxyproline metabolic process (GO:0019471)2.93045267
43protein carboxylation (GO:0018214)2.91429356
44peptidyl-glutamic acid carboxylation (GO:0017187)2.91429356
45gluconeogenesis (GO:0006094)2.90350914
46hyaluronan catabolic process (GO:0030214)2.88287830
47monosaccharide biosynthetic process (GO:0046364)2.85851861
48keratan sulfate catabolic process (GO:0042340)2.84432607
49maternal placenta development (GO:0001893)2.84325924
50pinocytosis (GO:0006907)2.82780225
51cellular copper ion homeostasis (GO:0006878)2.82688499
52regulation of nuclease activity (GO:0032069)2.82483076
53extracellular fibril organization (GO:0043206)2.80657423
54hexose biosynthetic process (GO:0019319)2.80598909
55receptor catabolic process (GO:0032801)2.77965271
56membrane protein intracellular domain proteolysis (GO:0031293)2.75921914
57insulin-like growth factor receptor signaling pathway (GO:0048009)2.75430130
58barbed-end actin filament capping (GO:0051016)2.75336553
59proline metabolic process (GO:0006560)2.74854503
60apoptotic process involved in morphogenesis (GO:0060561)2.74823079
61oxaloacetate metabolic process (GO:0006107)2.74491416
62cellular potassium ion homeostasis (GO:0030007)2.73815390
63epithelial cell-cell adhesion (GO:0090136)2.73530341
64endoplasmic reticulum unfolded protein response (GO:0030968)2.73475358
65fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.72462004
66tricarboxylic acid cycle (GO:0006099)2.71997342
67regulation of cholesterol biosynthetic process (GO:0045540)2.71726302
68galactose catabolic process (GO:0019388)2.71014397
69stress fiber assembly (GO:0043149)2.70606558
70protein N-linked glycosylation via asparagine (GO:0018279)2.70193412
71L-alpha-amino acid transmembrane transport (GO:1902475)2.69987805
72peptidyl-asparagine modification (GO:0018196)2.67476362
73regulation of hippo signaling (GO:0035330)2.67414346
74membrane protein ectodomain proteolysis (GO:0006509)2.66515052
75NADPH regeneration (GO:0006740)2.66196901
76L-serine transport (GO:0015825)2.65189512
77lysine catabolic process (GO:0006554)2.65115189
78lysine metabolic process (GO:0006553)2.65115189
79cell adhesion mediated by integrin (GO:0033627)2.64893316
80positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.64484284
81protein N-linked glycosylation (GO:0006487)2.63847975
82basement membrane organization (GO:0071711)2.63713254
83glutamine family amino acid biosynthetic process (GO:0009084)2.63512792
84regulation of integrin-mediated signaling pathway (GO:2001044)2.63237644
85positive regulation of actin filament depolymerization (GO:0030836)2.61649300
86negative regulation of fatty acid transport (GO:2000192)2.60724467
87positive regulation of glycogen biosynthetic process (GO:0045725)2.60459491
88glucose 6-phosphate metabolic process (GO:0051156)2.59915434
89negative regulation of lipid transport (GO:0032369)2.59608646
90maintenance of protein localization in organelle (GO:0072595)2.59574039
91cellular sodium ion homeostasis (GO:0006883)2.58938234
92adherens junction assembly (GO:0034333)2.58671194
93cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.56846874
94cellular response to unfolded protein (GO:0034620)2.56672585
95glial cell proliferation (GO:0014009)2.56639225
96ER-nucleus signaling pathway (GO:0006984)2.54862670
97muscle cell migration (GO:0014812)2.54370591
98glycosphingolipid catabolic process (GO:0046479)2.54114448
99nucleotide-sugar biosynthetic process (GO:0009226)2.53731794
100UV protection (GO:0009650)2.50764831
101retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.50484973
102protein localization to endosome (GO:0036010)2.50240880
103regulation of proton transport (GO:0010155)2.49708769
104positive regulation of protein deacetylation (GO:0090312)2.49390762
105layer formation in cerebral cortex (GO:0021819)2.48471869
106negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.47730865
107actin filament depolymerization (GO:0030042)2.47647019
108glucocorticoid receptor signaling pathway (GO:0042921)2.46234964
109fibril organization (GO:0097435)2.46113571
110hydrogen peroxide catabolic process (GO:0042744)2.45663608
111sphingolipid catabolic process (GO:0030149)2.45106808
112semaphorin-plexin signaling pathway (GO:0071526)2.44210016
113cell-substrate junction assembly (GO:0007044)2.43407000
114polarized epithelial cell differentiation (GO:0030859)2.42620864
115skin morphogenesis (GO:0043589)2.42031066
116regulation of cellular amino acid metabolic process (GO:0006521)2.41888823
117positive regulation of fatty acid beta-oxidation (GO:0032000)2.41417117
118NLS-bearing protein import into nucleus (GO:0006607)2.41154402
119glycolytic process (GO:0006096)2.40858987
120positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.38939795
121peptidyl-proline hydroxylation (GO:0019511)2.37394633
122cellular modified amino acid catabolic process (GO:0042219)2.37295935
123cell communication by electrical coupling (GO:0010644)2.37285961
124heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.36553612
125regulation of early endosome to late endosome transport (GO:2000641)2.35765141
126cellular response to topologically incorrect protein (GO:0035967)2.35516445
127response to laminar fluid shear stress (GO:0034616)2.35345322
128glycolipid catabolic process (GO:0019377)2.34920970
129intracellular estrogen receptor signaling pathway (GO:0030520)2.34456346
130lipopolysaccharide metabolic process (GO:0008653)2.34065417
131fibrinolysis (GO:0042730)2.33700193
132serine transport (GO:0032329)2.33439869
133dicarboxylic acid biosynthetic process (GO:0043650)2.33366732
134negative regulation of catenin import into nucleus (GO:0035414)2.33242937
135regulation of cholesterol storage (GO:0010885)2.32893557
136embryonic foregut morphogenesis (GO:0048617)2.32601549
137deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.32406425
138regulation of plasminogen activation (GO:0010755)2.32155082
139protein hydroxylation (GO:0018126)2.32037538
140positive regulation of triglyceride metabolic process (GO:0090208)2.31854188
141regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.31668076
142negative regulation of sterol transport (GO:0032372)2.31131099
143negative regulation of cholesterol transport (GO:0032375)2.31131099
144cell junction maintenance (GO:0034331)2.30385742
145membrane lipid catabolic process (GO:0046466)2.30015557
146negative regulation of heart growth (GO:0061117)2.29834360
147negative regulation of cardiac muscle tissue growth (GO:0055022)2.29834360
148regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.29776560
149planar cell polarity pathway involved in neural tube closure (GO:0090179)2.29674321
150regulation of autophagic vacuole assembly (GO:2000785)2.29192509
151cell-cell junction maintenance (GO:0045217)2.29177992
152renal system development (GO:0072001)2.28755070
153hormone catabolic process (GO:0042447)2.27968717
154vesicle coating (GO:0006901)2.27682458
155regulation of cholesterol esterification (GO:0010872)2.27664788
156growth hormone receptor signaling pathway (GO:0060396)2.26309707
157germ cell migration (GO:0008354)2.24544730
158tricarboxylic acid metabolic process (GO:0072350)2.23550133
159anatomical structure regression (GO:0060033)2.23353707
160positive regulation of glycogen metabolic process (GO:0070875)2.23236679
161alanine transport (GO:0032328)2.23234466
162establishment of apical/basal cell polarity (GO:0035089)2.22945106
163regulation of polysaccharide biosynthetic process (GO:0032885)2.22690577
164cytoplasmic mRNA processing body assembly (GO:0033962)2.21747817
165cortical actin cytoskeleton organization (GO:0030866)2.20988311
166negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.20036943
167regulation of ARF GTPase activity (GO:0032312)2.19595274
168low-density lipoprotein particle clearance (GO:0034383)2.18904489
169response to endoplasmic reticulum stress (GO:0034976)2.18701218
170glucose catabolic process (GO:0006007)2.17236446
171heparan sulfate proteoglycan metabolic process (GO:0030201)2.16409350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.19064078
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.03951340
3MYC_22102868_ChIP-Seq_BL_Human2.90574658
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78129278
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74238048
6LXR_22292898_ChIP-Seq_THP-1_Human2.64271405
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.56505744
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.54031089
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.52882744
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.48153467
11KDM2B_26808549_Chip-Seq_DND41_Human2.43549045
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38778473
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.26195487
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.24427737
15* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.20167856
16TCF7_22412390_ChIP-Seq_EML_Mouse2.19420554
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.18717327
18VDR_21846776_ChIP-Seq_THP-1_Human2.15480817
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.13919203
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06591526
21CLOCK_20551151_ChIP-Seq_293T_Human2.05842916
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04286661
23PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03611674
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.00906770
25RACK7_27058665_Chip-Seq_MCF-7_Human1.99838995
26* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98385120
27KDM2B_26808549_Chip-Seq_K562_Human1.98052367
28* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96233598
29ZNF263_19887448_ChIP-Seq_K562_Human1.94240233
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.94213464
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88149980
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86728047
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84069501
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83149549
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82520426
36P300_27058665_Chip-Seq_ZR-75-30cells_Human1.77163843
37KDM2B_26808549_Chip-Seq_JURKAT_Human1.74624430
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.74358994
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70634968
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.69893683
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68503083
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.68302357
43* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.67550591
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67240471
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66758185
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63370250
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61617185
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60721584
49DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.59090527
50* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.56198310
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.55089332
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.53765414
53* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52926986
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.52878417
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52803241
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51093092
57CREB1_26743006_Chip-Seq_LNCaP_Human1.48521716
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48154883
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.48056186
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47864412
61MYC_18555785_ChIP-Seq_MESCs_Mouse1.47594695
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46289545
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45862937
64P68_20966046_ChIP-Seq_HELA_Human1.44889722
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44871458
66* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43490660
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42536591
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41988721
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.41967240
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41927062
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41567326
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41501944
73DCP1A_22483619_ChIP-Seq_HELA_Human1.40601509
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40013385
75* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38564357
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37897229
77* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.37514496
78UTX_26944678_Chip-Seq_JUKART_Human1.36764478
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35725138
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35245041
81ATF3_27146783_Chip-Seq_COLON_Human1.34398206
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33668148
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32154416
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31685385
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31292165
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31003812
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.28714502
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28065362
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28052435
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27021511
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26981061
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.26800140
93ETS1_20019798_ChIP-Seq_JURKAT_Human1.26781111
94TFEB_21752829_ChIP-Seq_HELA_Human1.26726262
95TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.26105191
96MAF_26560356_Chip-Seq_TH1_Human1.25969776
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25891233
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.25554988
99SMC4_20622854_ChIP-Seq_HELA_Human1.24810150
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24246458
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23266860
102TP53_22127205_ChIP-Seq_IMR90_Human1.22737738
103* GABP_19822575_ChIP-Seq_HepG2_Human1.22398547
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21214836
105TBX5_21415370_ChIP-Seq_HL-1_Mouse1.21011340
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.19189252
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17354653
108CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16917789
109NCOR1_26117541_ChIP-Seq_K562_Human1.16901727
110PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16488553
111XRN2_22483619_ChIP-Seq_HELA_Human1.16003358
112SA1_27219007_Chip-Seq_ERYTHROID_Human1.15850062
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15258195
114ELF1_20517297_ChIP-Seq_JURKAT_Human1.13854475
115VDR_24763502_ChIP-Seq_THP-1_Human1.13838502
116DROSHA_22980978_ChIP-Seq_HELA_Human1.13122092
117ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12811501
118MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12685123
119TBX20_22328084_ChIP-Seq_HEART_Mouse1.12590071
120TBX20_22080862_ChIP-Seq_HEART_Mouse1.12590071
121FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12162133
122CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12018486
123ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11074059
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11071345
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10869084
126TP63_22573176_ChIP-Seq_HFKS_Human1.10432925
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09950412
128SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09611247
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08617056
130ESR1_21235772_ChIP-Seq_MCF-7_Human1.07801574
131STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06050397
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05716450
133FOXA2_19822575_ChIP-Seq_HepG2_Human1.05178555
134NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04712670
135SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03740115
136TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.02695841
137RARB_24833708_ChIP-Seq_LIVER_Mouse1.02357095
138TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02039011
139SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01510065
140GATA6_25053715_ChIP-Seq_YYC3_Human1.01171992
141SPI1_23127762_ChIP-Seq_K562_Human1.00801058
142FOXM1_23109430_ChIP-Seq_U2OS_Human1.00566192
143CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00434764
144* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00386307
145GATA1_19941827_ChIP-Seq_MEL_Mouse1.00379336
146GATA1_19941826_ChIP-Seq_K562_Human1.00162601
147MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99039938
148* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99005121
149PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98903774
150ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98852353
151SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98802328
152SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97688047
153NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96978677
154SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96782172
155SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96727863
156BCOR_27268052_Chip-Seq_Bcells_Human0.96319489
157YY1_21170310_ChIP-Seq_MESCs_Mouse0.96153045
158SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95865017
159SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95865017
160BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95405344
161* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95004742
162VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94562503
163FOXO3_23340844_ChIP-Seq_DLD1_Human0.94470463
164CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94289077
165CTCF_27219007_Chip-Seq_Bcells_Human0.93286587
166* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93283436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.16902520
2MP0003300_gastrointestinal_ulcer3.46978813
3MP0005257_abnormal_intraocular_pressure3.01641368
4MP0008961_abnormal_basal_metabolism2.80573168
5MP0005360_urolithiasis2.60111753
6MP0002877_abnormal_melanocyte_morpholog2.56537620
7MP0010234_abnormal_vibrissa_follicle2.53214048
8MP0008438_abnormal_cutaneous_collagen2.44169265
9MP0005076_abnormal_cell_differentiation2.40934579
10MP0009840_abnormal_foam_cell2.38021974
11MP0010352_gastrointestinal_tract_polyps2.32649486
12MP0005451_abnormal_body_composition2.31237554
13MP0004858_abnormal_nervous_system2.26360756
14MP0005408_hypopigmentation2.11379366
15MP0001849_ear_inflammation2.10278943
16MP0009278_abnormal_bone_marrow2.09607550
17MP0003566_abnormal_cell_adhesion2.07631562
18MP0003303_peritoneal_inflammation2.02453335
19MP0002139_abnormal_hepatobiliary_system1.88436609
20MP0003806_abnormal_nucleotide_metabolis1.84310389
21MP0004233_abnormal_muscle_weight1.84227266
22MP0008875_abnormal_xenobiotic_pharmacok1.83175619
23MP0002089_abnormal_postnatal_growth/wei1.78740582
24MP0005165_increased_susceptibility_to1.78289309
25MP0003172_abnormal_lysosome_physiology1.70020312
26MP0005623_abnormal_meninges_morphology1.67303711
27MP0003283_abnormal_digestive_organ1.61322608
28MP0003115_abnormal_respiratory_system1.58725152
29MP0005365_abnormal_bile_salt1.55700853
30MP0003186_abnormal_redox_activity1.55277949
31MP0008260_abnormal_autophagy1.54977090
32MP0003123_paternal_imprinting1.53903944
33MP0000013_abnormal_adipose_tissue1.52640318
34MP0006054_spinal_hemorrhage1.51998443
35MP0002653_abnormal_ependyma_morphology1.51848756
36MP0009780_abnormal_chondrocyte_physiolo1.50561749
37MP0003329_amyloid_beta_deposits1.50448541
38MP0005330_cardiomyopathy1.46379791
39MP0001348_abnormal_lacrimal_gland1.46260287
40MP0003045_fibrosis1.46070308
41MP0000537_abnormal_urethra_morphology1.44762613
42MP0005083_abnormal_biliary_tract1.44599273
43MP0001666_abnormal_nutrient_absorption1.42477929
44MP0000733_abnormal_muscle_development1.42445336
45MP0001958_emphysema1.42068382
46MP0003252_abnormal_bile_duct1.38770401
47MP0010329_abnormal_lipoprotein_level1.36658929
48MP0004272_abnormal_basement_membrane1.36249034
49MP0003191_abnormal_cellular_cholesterol1.33632612
50MP0002295_abnormal_pulmonary_circulatio1.33008509
51MP0001542_abnormal_bone_strength1.30613416
52MP0001661_extended_life_span1.27099510
53MP0005501_abnormal_skin_physiology1.27049030
54MP0000534_abnormal_ureter_morphology1.26737071
55MP0010030_abnormal_orbit_morphology1.22445345
56MP0004264_abnormal_extraembryonic_tissu1.21043348
57MP0005023_abnormal_wound_healing1.20416269
58MP0003091_abnormal_cell_migration1.19940191
59MP0000003_abnormal_adipose_tissue1.18387557
60MP0005275_abnormal_skin_tensile1.16850578
61MP0003950_abnormal_plasma_membrane1.14473720
62MP0000604_amyloidosis1.14386230
63MP0000858_altered_metastatic_potential1.13680621
64MP0003279_aneurysm1.12269504
65MP0009384_cardiac_valve_regurgitation1.11819946
66MP0001243_abnormal_dermal_layer1.11559863
67MP0005058_abnormal_lysosome_morphology1.09902630
68MP0005503_abnormal_tendon_morphology1.05013780
69MP0001915_intracranial_hemorrhage1.04801108
70MP0002909_abnormal_adrenal_gland1.03628650
71MP0000372_irregular_coat_pigmentation1.02218233
72MP0005508_abnormal_skeleton_morphology1.01800304
73MP0005375_adipose_tissue_phenotype0.99900938
74MP0009053_abnormal_anal_canal0.99794018
75MP0005248_abnormal_Harderian_gland0.99659717
76MP0004185_abnormal_adipocyte_glucose0.99576768
77MP0004197_abnormal_fetal_growth/weight/0.99081577
78MP0005377_hearing/vestibular/ear_phenot0.98543978
79MP0003878_abnormal_ear_physiology0.98543978
80MP0002896_abnormal_bone_mineralization0.96868036
81MP0006082_CNS_inflammation0.96343561
82MP0005670_abnormal_white_adipose0.96117189
83MP0003075_altered_response_to0.94862597
84MP0005171_absent_coat_pigmentation0.94169174
85MP0004885_abnormal_endolymph0.93755300
86MP0004782_abnormal_surfactant_physiolog0.93077566
87MP0001873_stomach_inflammation0.93072529
88MP0000609_abnormal_liver_physiology0.92957006
89MP0001881_abnormal_mammary_gland0.92498249
90MP0004947_skin_inflammation0.91994245
91MP0010630_abnormal_cardiac_muscle0.91123523
92MP0004130_abnormal_muscle_cell0.90639471
93MP0005584_abnormal_enzyme/coenzyme_acti0.89620717
94MP0010368_abnormal_lymphatic_system0.88887561
95MP0000343_altered_response_to0.88488862
96MP0004087_abnormal_muscle_fiber0.88006655
97MP0000751_myopathy0.87351495
98MP0010771_integument_phenotype0.87108855
99MP0001216_abnormal_epidermal_layer0.86955264
100MP0000750_abnormal_muscle_regeneration0.86761484
101MP0002090_abnormal_vision0.85900849
102MP0000428_abnormal_craniofacial_morphol0.84466419
103MP0009672_abnormal_birth_weight0.84242838
104MP0002697_abnormal_eye_size0.84237083
105MP0001756_abnormal_urination0.83544297
106MP0005164_abnormal_response_to0.81659652
107MP0002269_muscular_atrophy0.81249818
108MP0000681_abnormal_thyroid_gland0.80916454
109MP0002234_abnormal_pharynx_morphology0.79909718
110MP0005666_abnormal_adipose_tissue0.79300080
111MP0000358_abnormal_cell_content/0.78788062
112MP0004084_abnormal_cardiac_muscle0.78540336
113MP0001533_abnormal_skeleton_physiology0.77581697
114MP0009643_abnormal_urine_homeostasis0.77248066
115MP0001853_heart_inflammation0.76317313
116MP0002925_abnormal_cardiovascular_devel0.76112440
117MP0005167_abnormal_blood-brain_barrier0.75121102
118MP0005390_skeleton_phenotype0.74454427
119MP0003786_premature_aging0.73754351
120MP0004019_abnormal_vitamin_homeostasis0.72058787
121MP0000747_muscle_weakness0.71905451
122MP0010307_abnormal_tumor_latency0.71530334
123MP0008770_decreased_survivor_rate0.71463962
124MP0003942_abnormal_urinary_system0.71352419
125MP0006036_abnormal_mitochondrial_physio0.71300011
126MP0002118_abnormal_lipid_homeostasis0.71294799
127MP0001730_embryonic_growth_arrest0.71165558
128MP0002796_impaired_skin_barrier0.71066030
129MP0002086_abnormal_extraembryonic_tissu0.70764816
130MP0000749_muscle_degeneration0.70138078
131MP0002092_abnormal_eye_morphology0.69986521
132MP0000678_abnormal_parathyroid_gland0.69963720
133MP0000767_abnormal_smooth_muscle0.69654928
134MP0002970_abnormal_white_adipose0.69086947
135MP0003795_abnormal_bone_structure0.69021142
136MP0005220_abnormal_exocrine_pancreas0.68833920
137MP0005085_abnormal_gallbladder_physiolo0.67231411
138MP0002168_other_aberrant_phenotype0.66956358
139MP0005319_abnormal_enzyme/_coenzyme0.66712911
140MP0005197_abnormal_uvea_morphology0.66100136
141MP0005379_endocrine/exocrine_gland_phen0.65179387
142MP0002084_abnormal_developmental_patter0.65166277
143MP0002060_abnormal_skin_morphology0.64539968
144MP0000598_abnormal_liver_morphology0.64033866
145MP0003453_abnormal_keratinocyte_physiol0.63475298
146MP0000266_abnormal_heart_morphology0.62186761
147MP0002128_abnormal_blood_circulation0.60226320
148MP0005332_abnormal_amino_acid0.59817201
149MP0005166_decreased_susceptibility_to0.59524301
150MP0005464_abnormal_platelet_physiology0.59465785

Predicted human phenotypes

RankGene SetZ-score
1Vertebral compression fractures (HP:0002953)4.70185741
2Hand muscle atrophy (HP:0009130)3.77032433
3Cerebral aneurysm (HP:0004944)3.71767404
4Abnormality of glycolipid metabolism (HP:0010969)3.70297103
5Abnormality of liposaccharide metabolism (HP:0010968)3.70297103
6Abnormality of glycosphingolipid metabolism (HP:0004343)3.70297103
7Hyperacusis (HP:0010780)3.60934749
8Distal upper limb amyotrophy (HP:0007149)3.59087481
9Upper limb amyotrophy (HP:0009129)3.59087481
10Protrusio acetabuli (HP:0003179)3.51952263
11Shallow orbits (HP:0000586)3.20530672
12Vascular calcification (HP:0004934)3.15337883
13Cholecystitis (HP:0001082)3.15046074
14Abnormal gallbladder physiology (HP:0012438)3.15046074
15Cardiovascular calcification (HP:0011915)3.07015049
16J-shaped sella turcica (HP:0002680)3.05952112
17Vacuolated lymphocytes (HP:0001922)3.04236962
18Hypokinesia (HP:0002375)3.02556506
19Abnormality of dentin (HP:0010299)2.89910482
20Lymphangioma (HP:0100764)2.88964429
21Distal lower limb muscle weakness (HP:0009053)2.88094138
22Abnormality of the lower motor neuron (HP:0002366)2.78847714
23Short nail (HP:0001799)2.68248270
24Elfin facies (HP:0004428)2.67722589
25Insomnia (HP:0100785)2.62702023
26Abnormality of aromatic amino acid family metabolism (HP:0004338)2.57761354
27Aneurysm (HP:0002617)2.55082543
28Broad metatarsal (HP:0001783)2.54411833
29Bladder diverticulum (HP:0000015)2.53213797
30Abnormality of glycolysis (HP:0004366)2.52683911
31Trismus (HP:0000211)2.46795504
32Deep venous thrombosis (HP:0002625)2.46378362
33Ankle contracture (HP:0006466)2.45053278
34Macroorchidism (HP:0000053)2.42198934
35Renovascular hypertension (HP:0100817)2.42177347
36Abnormality of the distal phalanges of the toes (HP:0010182)2.42016861
37Back pain (HP:0003418)2.38066987
38Prolonged neonatal jaundice (HP:0006579)2.34701678
39Nuclear cataract (HP:0100018)2.32721148
40Generalized amyotrophy (HP:0003700)2.32697529
41Aortic aneurysm (HP:0004942)2.32262796
42Enlarged penis (HP:0000040)2.31645191
43Ulnar bowing (HP:0003031)2.31613034
44Renal duplication (HP:0000075)2.29959629
45Spinal rigidity (HP:0003306)2.29879712
46Mitral valve prolapse (HP:0001634)2.29825186
47Neoplasm of the heart (HP:0100544)2.27247294
48Pseudobulbar signs (HP:0002200)2.23924255
49Cervical subluxation (HP:0003308)2.22873669
50Glucose intolerance (HP:0000833)2.22603399
51Premature rupture of membranes (HP:0001788)2.20266070
52Loss of speech (HP:0002371)2.19679173
53Increased serum pyruvate (HP:0003542)2.18355329
54Urinary glycosaminoglycan excretion (HP:0003541)2.18269474
55Mucopolysacchariduria (HP:0008155)2.18269474
56Disproportionate tall stature (HP:0001519)2.17641019
57Osteolytic defects of the hand bones (HP:0009699)2.16754700
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.16754700
59Turricephaly (HP:0000262)2.15985359
60Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11511979
61Skin nodule (HP:0200036)2.11331159
62Abnormality of the acetabulum (HP:0003170)2.10811485
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10523394
64Abnormality of polysaccharide metabolism (HP:0011012)2.10523394
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10523394
66Wormian bones (HP:0002645)2.09509940
67Bowel diverticulosis (HP:0005222)2.08229744
68Thin bony cortex (HP:0002753)2.08133836
69Genu recurvatum (HP:0002816)2.07066342
70Testicular atrophy (HP:0000029)2.05336324
71Orthostatic hypotension (HP:0001278)2.04872822
72Type I transferrin isoform profile (HP:0003642)2.03909917
73Progressive neurologic deterioration (HP:0002344)2.03806417
74Short 4th metacarpal (HP:0010044)2.02855037
75Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02855037
76Aortic dissection (HP:0002647)2.02643905
77Deviation of the hallux (HP:0010051)2.01578507
78Hallux valgus (HP:0001822)2.01525413
79Distal lower limb amyotrophy (HP:0008944)2.01502545
80Abnormality of the Achilles tendon (HP:0005109)2.01260863
81Entropion (HP:0000621)2.00282596
82Overriding aorta (HP:0002623)1.98985910
83Joint stiffness (HP:0001387)1.98854594
84Achilles tendon contracture (HP:0001771)1.98597187
85Abnormality of carpal bone ossification (HP:0006257)1.97009828
86Dilatation of the ascending aorta (HP:0005111)1.96738043
87Elbow flexion contracture (HP:0002987)1.96661176
88Dysmetric saccades (HP:0000641)1.95628805
89Ankyloglossia (HP:0010296)1.93489019
90Long toe (HP:0010511)1.93129621
91Centrally nucleated skeletal muscle fibers (HP:0003687)1.93033938
92Striae distensae (HP:0001065)1.92429538
93Flat acetabular roof (HP:0003180)1.91771212
94Growth hormone excess (HP:0000845)1.89890988
95Abnormality of the 4th metacarpal (HP:0010012)1.89447789
96Rectal prolapse (HP:0002035)1.89081662
97Amyloidosis (HP:0011034)1.88804815
98Increased cerebral lipofuscin (HP:0011813)1.87612224
99Peritonitis (HP:0002586)1.86078149
100Stridor (HP:0010307)1.85450926
101Axonal loss (HP:0003447)1.85323279
102Dysostosis multiplex (HP:0000943)1.84837200
103Increased density of long bones (HP:0006392)1.83890985
104Abnormality of the umbilical cord (HP:0010881)1.82142050
105Beaking of vertebral bodies (HP:0004568)1.81962450
106Atelectasis (HP:0100750)1.81574754
107Pointed chin (HP:0000307)1.81465614
108Reduced subcutaneous adipose tissue (HP:0003758)1.81203005
109Spastic diplegia (HP:0001264)1.80817236
110Rough bone trabeculation (HP:0100670)1.80520467
111Hyperparathyroidism (HP:0000843)1.80373383
112Atrophic scars (HP:0001075)1.79314352
113Cardiomegaly (HP:0001640)1.78972650
114Nonimmune hydrops fetalis (HP:0001790)1.78575478
115Ovoid vertebral bodies (HP:0003300)1.77758370
116Asymmetric septal hypertrophy (HP:0001670)1.77606809
117Myocardial infarction (HP:0001658)1.77119075
118Biconcave vertebral bodies (HP:0004586)1.77079579
119Astrocytoma (HP:0009592)1.74948597
120Abnormality of the astrocytes (HP:0100707)1.74948597
121Hypoalphalipoproteinemia (HP:0003233)1.73128742
122Bowing of the arm (HP:0006488)1.72274737
123Bowed forearm bones (HP:0003956)1.72274737
124Abnormal delivery (HP:0001787)1.71792166
125Systemic lupus erythematosus (HP:0002725)1.71047418
126Congenital glaucoma (HP:0001087)1.70752040
127Blue sclerae (HP:0000592)1.70486693
128Coxa vara (HP:0002812)1.70012876
129Abnormality of oral frenula (HP:0000190)1.69390087
130Flat cornea (HP:0007720)1.68972074
131Insulin resistance (HP:0000855)1.68641287
132Cerebral inclusion bodies (HP:0100314)1.68571679
133Upper limb muscle weakness (HP:0003484)1.67244135
134Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66135764
135Abnormality of complement system (HP:0005339)1.65927234
136Increased nuchal translucency (HP:0010880)1.65790910
137Hemiplegia (HP:0002301)1.65629246
138Abdominal distention (HP:0003270)1.64912188
139Unilateral renal agenesis (HP:0000122)1.64618502
140Follicular hyperkeratosis (HP:0007502)1.63882109
141Hypoventilation (HP:0002791)1.63086834
142Fibroma (HP:0010614)1.62915244
143Mesangial abnormality (HP:0001966)1.62783345
144Metaphyseal cupping (HP:0003021)1.62031325
145Mildly elevated creatine phosphokinase (HP:0008180)1.61798213
146Increased connective tissue (HP:0009025)1.61528069
147Gout (HP:0001997)1.61482614
148Opisthotonus (HP:0002179)1.60539313
149Mitral stenosis (HP:0001718)1.59467463
150Diminished movement (HP:0002374)1.57894930
151Interstitial pulmonary disease (HP:0006530)1.57826006
152Hypercortisolism (HP:0001578)1.57614872
153Broad face (HP:0000283)1.57568966
154Severe short stature (HP:0003510)1.57069780
155Right ventricular cardiomyopathy (HP:0011663)1.56841762
156Supranuclear gaze palsy (HP:0000605)1.56319933
157Limb-girdle muscle atrophy (HP:0003797)1.56253729
158Hamartoma of the eye (HP:0010568)1.55970149
159Buphthalmos (HP:0000557)1.54028079
160Polycythemia (HP:0001901)1.54005832
161Ependymoma (HP:0002888)1.52486257
162Subacute progressive viral hepatitis (HP:0006572)1.52363582
163Slender build (HP:0001533)1.50947897
164Ectopia lentis (HP:0001083)1.50772866
165Fragile skin (HP:0001030)1.49991253
166Frequent falls (HP:0002359)1.49910653
167Fibrous tissue neoplasm (HP:0012316)1.49557993
168Increased variability in muscle fiber diameter (HP:0003557)1.49216259
169Arterial tortuosity (HP:0005116)1.48613284
170Xanthomatosis (HP:0000991)1.47416276

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.01451819
2EEF2K3.94608189
3PKN23.87299803
4ERN13.83463754
5NME23.82985082
6MAP3K102.97814277
7MST1R2.90421940
8SIK12.78953209
9IRAK32.75705752
10LIMK12.75040823
11ICK2.51067214
12RIPK12.48664757
13VRK22.28990318
14CDK122.23131136
15EIF2AK12.15464203
16PTK62.11253089
17PBK2.10972476
18MAP3K32.02642471
19MYLK2.02105198
20BMX1.82579981
21PIM21.81566945
22TTN1.67391514
23ARAF1.65825198
24EPHB11.64283734
25PDGFRA1.64277904
26SMG11.62475349
27MET1.58982069
28MAP3K121.53916059
29PRKD31.48184151
30DDR21.47269112
31LRRK21.44590612
32PAK41.42891619
33CAMK1G1.41952628
34FGFR41.34093864
35PDK21.32136545
36TYRO31.31860039
37TAOK11.31526852
38CAMK1D1.30969052
39LMTK21.28472941
40MTOR1.25761522
41ALK1.23971492
42SIK21.22232150
43PTK21.20940192
44ABL21.19099086
45MAP4K11.17187093
46SCYL21.13823695
47PAK61.10553278
48TAOK21.10479967
49NEK11.09194404
50MAP3K71.07915374
51MAP3K91.06832715
52RET1.04361754
53MST41.03941062
54SIK31.02507134
55GRK61.00208154
56DMPK0.99182094
57CDK80.98739536
58LATS10.95616229
59NME10.94179246
60DAPK10.93111652
61KSR20.92692677
62PAK20.92552928
63ERBB40.89746969
64PRKCH0.84760729
65CAMKK10.84712615
66STK160.84283694
67STK100.78679521
68TESK10.76151605
69CDK70.75724322
70BRSK10.75548131
71CDK60.75501582
72TBK10.75230517
73DYRK1B0.74305696
74NEK20.72830902
75FGFR10.71897992
76LATS20.70806615
77PRKCI0.69148719
78STK380.67589571
79MOS0.64851318
80FGFR30.64809426
81RPS6KA20.63721896
82PDGFRB0.63596461
83BUB10.62150515
84CAMK2D0.61945695
85SGK30.59916761
86CDK40.59493126
87BCKDK0.59092834
88RPS6KB20.58819923
89EPHB20.58714853
90CAMK2G0.57031698
91PRKG20.56301313
92EPHA20.56012618
93MUSK0.55041997
94ERBB20.55025176
95FER0.54030654
96EIF2AK30.53453554
97PRPF4B0.53161781
98ILK0.52531054
99MAPK110.52458354
100MARK20.51948885
101STK40.51629018
102CDC42BPA0.50683382
103MAPKAPK20.50595276
104DAPK30.50483159
105PHKG20.49581021
106PHKG10.49581021
107TESK20.49303833
108FGFR20.49166235
109DAPK20.48349085
110PAK10.48336783
111PAK30.47703159
112NTRK20.47677189
113MAP3K110.47039996
114TGFBR20.46776726
115MAPKAPK30.46739586
116ZAP700.46723057
117BRAF0.46386621
118NTRK10.46262478
119GSK3A0.46046640
120CSK0.44688935
121CSF1R0.44357906
122RPS6KA10.43648372
123PRKD10.42261715
124ROCK20.42203890
125MAP3K20.41420820
126MAP3K10.40168983
127TYK20.39722408
128EPHA30.39123924
129SRC0.38891073
130JAK10.38884332
131PDPK10.38379705
132CLK10.37237068
133MAP2K30.36919506
134JAK20.36821067
135PTK2B0.36724007
136KDR0.36630065
137MAP3K80.36561759
138CDK90.35863863
139PRKD20.35794417
140UHMK10.34880277
141AKT20.34704267
142MAP2K20.34292902
143TRIM280.34051415
144PRKAA10.33279958
145FLT30.32869484
146MATK0.32789553
147BRD40.32325084
148MAP2K60.31928237
149ROCK10.31802143
150HCK0.31651643
151HIPK20.30889979
152EGFR0.30644912

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.97452162
2Fatty acid elongation_Homo sapiens_hsa000622.96736109
3Nitrogen metabolism_Homo sapiens_hsa009102.92661978
4Proteasome_Homo sapiens_hsa030502.69672325
5Vibrio cholerae infection_Homo sapiens_hsa051102.23063858
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.13436892
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.05038664
8Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.02873020
9Glutathione metabolism_Homo sapiens_hsa004801.95848013
10Vitamin B6 metabolism_Homo sapiens_hsa007501.92566928
11Sulfur metabolism_Homo sapiens_hsa009201.91507092
12Lysine degradation_Homo sapiens_hsa003101.82230780
13Folate biosynthesis_Homo sapiens_hsa007901.81119108
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80917221
15Sulfur relay system_Homo sapiens_hsa041221.75729074
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60407590
17Phenylalanine metabolism_Homo sapiens_hsa003601.58706198
18Bile secretion_Homo sapiens_hsa049761.54719827
19Arginine biosynthesis_Homo sapiens_hsa002201.42682308
20Chronic myeloid leukemia_Homo sapiens_hsa052201.40268157
21Sphingolipid metabolism_Homo sapiens_hsa006001.37650796
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35137674
23mTOR signaling pathway_Homo sapiens_hsa041501.34987031
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25816911
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.25140617
26Tyrosine metabolism_Homo sapiens_hsa003501.24121450
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22892342
28Notch signaling pathway_Homo sapiens_hsa043301.22502615
29* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21150451
30Biosynthesis of amino acids_Homo sapiens_hsa012301.20339078
31Fatty acid metabolism_Homo sapiens_hsa012121.19567988
32Fatty acid degradation_Homo sapiens_hsa000711.18834350
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17860260
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17472141
35Fat digestion and absorption_Homo sapiens_hsa049751.15071677
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14769082
37Protein digestion and absorption_Homo sapiens_hsa049741.13796334
38Proteoglycans in cancer_Homo sapiens_hsa052051.13796015
39Insulin resistance_Homo sapiens_hsa049311.12638736
40Focal adhesion_Homo sapiens_hsa045101.10968406
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09379414
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07349127
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.06008991
44Bladder cancer_Homo sapiens_hsa052191.05018832
45PPAR signaling pathway_Homo sapiens_hsa033201.04258093
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.02956709
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01867714
48Glioma_Homo sapiens_hsa052141.01615158
49Endometrial cancer_Homo sapiens_hsa052131.01180468
50Arginine and proline metabolism_Homo sapiens_hsa003300.99933257
51Adherens junction_Homo sapiens_hsa045200.99345641
52ECM-receptor interaction_Homo sapiens_hsa045120.97469925
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96730095
54Non-small cell lung cancer_Homo sapiens_hsa052230.96599123
55Amoebiasis_Homo sapiens_hsa051460.93849487
56VEGF signaling pathway_Homo sapiens_hsa043700.92158914
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92028082
58Carbon metabolism_Homo sapiens_hsa012000.92022367
59Pancreatic cancer_Homo sapiens_hsa052120.91681544
60Steroid biosynthesis_Homo sapiens_hsa001000.90296779
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.89649743
62Peroxisome_Homo sapiens_hsa041460.89238783
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88993769
64Fatty acid biosynthesis_Homo sapiens_hsa000610.88946003
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88053067
66Oxidative phosphorylation_Homo sapiens_hsa001900.85860248
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85719658
68AMPK signaling pathway_Homo sapiens_hsa041520.84903849
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82996303
70Small cell lung cancer_Homo sapiens_hsa052220.82877290
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81471490
72Lysosome_Homo sapiens_hsa041420.81188621
73Type II diabetes mellitus_Homo sapiens_hsa049300.80550311
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.79779195
75Insulin signaling pathway_Homo sapiens_hsa049100.78693798
76Estrogen signaling pathway_Homo sapiens_hsa049150.78658554
77Colorectal cancer_Homo sapiens_hsa052100.77995197
78Renal cell carcinoma_Homo sapiens_hsa052110.77598435
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75617267
80Protein export_Homo sapiens_hsa030600.74193302
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73527923
82Dilated cardiomyopathy_Homo sapiens_hsa054140.73366378
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.72698706
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72563404
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72429390
86Hippo signaling pathway_Homo sapiens_hsa043900.71602613
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71594531
88* Metabolic pathways_Homo sapiens_hsa011000.71522973
89Tryptophan metabolism_Homo sapiens_hsa003800.70910718
90Acute myeloid leukemia_Homo sapiens_hsa052210.70741318
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.70472789
92Basal cell carcinoma_Homo sapiens_hsa052170.69755577
93Glycerolipid metabolism_Homo sapiens_hsa005610.69373558
94Gastric acid secretion_Homo sapiens_hsa049710.68699601
95Dorso-ventral axis formation_Homo sapiens_hsa043200.68648536
96Pyrimidine metabolism_Homo sapiens_hsa002400.67501561
97Thyroid hormone synthesis_Homo sapiens_hsa049180.67398918
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66231056
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66222660
100Renin-angiotensin system_Homo sapiens_hsa046140.65760862
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64860003
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64844843
103Glucagon signaling pathway_Homo sapiens_hsa049220.64082643
104Collecting duct acid secretion_Homo sapiens_hsa049660.64070699
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63723425
106Pancreatic secretion_Homo sapiens_hsa049720.62336741
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62118158
108Viral myocarditis_Homo sapiens_hsa054160.61918530
109Galactose metabolism_Homo sapiens_hsa000520.60783638
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.60546461
111Pyruvate metabolism_Homo sapiens_hsa006200.60417127
112MicroRNAs in cancer_Homo sapiens_hsa052060.59807236
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.58597446
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58426750
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58346793
116B cell receptor signaling pathway_Homo sapiens_hsa046620.57908333
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57084582
118N-Glycan biosynthesis_Homo sapiens_hsa005100.55333216
119Pentose phosphate pathway_Homo sapiens_hsa000300.55201755
120Toxoplasmosis_Homo sapiens_hsa051450.55182627
121Butanoate metabolism_Homo sapiens_hsa006500.55114662
122Endocytosis_Homo sapiens_hsa041440.54905503
123Fructose and mannose metabolism_Homo sapiens_hsa000510.54765985
124Complement and coagulation cascades_Homo sapiens_hsa046100.54480450
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54425186
126Base excision repair_Homo sapiens_hsa034100.54341272
127Starch and sucrose metabolism_Homo sapiens_hsa005000.54228919
128Platelet activation_Homo sapiens_hsa046110.54088478
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54018335
130Mineral absorption_Homo sapiens_hsa049780.53184872
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52954624
132Huntingtons disease_Homo sapiens_hsa050160.52459350
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.51993956
134Prion diseases_Homo sapiens_hsa050200.51698501
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51367543
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49644624
137Alzheimers disease_Homo sapiens_hsa050100.47680709
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44027277
139Thyroid cancer_Homo sapiens_hsa052160.43572289
140Parkinsons disease_Homo sapiens_hsa050120.43538762
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41987744
142Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37620591
143DNA replication_Homo sapiens_hsa030300.34020422
144Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31793309
145Shigellosis_Homo sapiens_hsa051310.28828753
146beta-Alanine metabolism_Homo sapiens_hsa004100.28810483
147Chemical carcinogenesis_Homo sapiens_hsa052040.28720031
148One carbon pool by folate_Homo sapiens_hsa006700.28215797
149Nucleotide excision repair_Homo sapiens_hsa034200.26286018
150Vitamin digestion and absorption_Homo sapiens_hsa049770.23389803
151Synaptic vesicle cycle_Homo sapiens_hsa047210.23126233
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20552126

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