PIGU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)7.25403588
2mannosylation (GO:0097502)6.03519783
3nucleotide transmembrane transport (GO:1901679)5.36678934
4mitochondrial RNA metabolic process (GO:0000959)5.19844659
5presynaptic membrane assembly (GO:0097105)5.17462382
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.15646922
7maturation of 5.8S rRNA (GO:0000460)5.13202680
8histone H3-K36 demethylation (GO:0070544)4.80842887
9daunorubicin metabolic process (GO:0044597)4.58694853
10polyketide metabolic process (GO:0030638)4.58694853
11doxorubicin metabolic process (GO:0044598)4.58694853
12regulation of telomere maintenance via telomerase (GO:0032210)4.35074846
13signal peptide processing (GO:0006465)4.31723757
14cullin deneddylation (GO:0010388)4.30752972
15tRNA methylation (GO:0030488)4.26570841
16ribosomal small subunit assembly (GO:0000028)4.26471470
17DNA integration (GO:0015074)4.20509171
18protein deneddylation (GO:0000338)3.91222886
19mitotic metaphase plate congression (GO:0007080)3.76353695
20DNA deamination (GO:0045006)3.72103823
21telomere maintenance via semi-conservative replication (GO:0032201)3.59279755
22regulation of transcription from RNA polymerase I promoter (GO:0006356)3.53601104
23deoxyribonucleotide biosynthetic process (GO:0009263)3.49609810
24deoxyribose phosphate biosynthetic process (GO:0046385)3.46468075
252-deoxyribonucleotide biosynthetic process (GO:0009265)3.46468075
26metaphase plate congression (GO:0051310)3.45111003
27cellular response to interferon-beta (GO:0035458)3.43016869
28L-serine metabolic process (GO:0006563)3.42611354
29natural killer cell activation involved in immune response (GO:0002323)3.40268182
30preassembly of GPI anchor in ER membrane (GO:0016254)3.40042893
31* GPI anchor biosynthetic process (GO:0006506)3.35502500
32regulation of nuclear cell cycle DNA replication (GO:0033262)3.33051812
33DNA ligation (GO:0006266)3.28101706
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.27972346
35establishment of viral latency (GO:0019043)3.25010147
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19600963
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.19482280
38nucleotide transport (GO:0006862)3.17345800
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15955132
40regulation of chromatin silencing (GO:0031935)3.14985976
41deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.13794075
42kinetochore assembly (GO:0051382)3.13183892
43branched-chain amino acid catabolic process (GO:0009083)3.12399953
44telomere maintenance via recombination (GO:0000722)3.12278789
45viral mRNA export from host cell nucleus (GO:0046784)3.11117839
46positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10029190
47protein localization to kinetochore (GO:0034501)3.09565913
48cholesterol biosynthetic process (GO:0006695)3.08429820
49peptidyl-histidine modification (GO:0018202)3.07002455
50pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.05773741
51tRNA modification (GO:0006400)3.03442344
52histone H2A acetylation (GO:0043968)3.01591952
53non-recombinational repair (GO:0000726)2.95030424
54double-strand break repair via nonhomologous end joining (GO:0006303)2.95030424
55DNA strand elongation involved in DNA replication (GO:0006271)2.94766966
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.92717627
57tRNA processing (GO:0008033)2.90966826
58regulation of mitochondrial translation (GO:0070129)2.90874828
59DNA damage response, detection of DNA damage (GO:0042769)2.90557551
60negative regulation of gene silencing (GO:0060969)2.90233483
61DNA strand elongation (GO:0022616)2.90000999
62proteasome assembly (GO:0043248)2.89486963
63telomere maintenance via telomere lengthening (GO:0010833)2.88145052
64regulation of spindle organization (GO:0090224)2.87996430
65spliceosomal snRNP assembly (GO:0000387)2.87423953
66negative regulation of ligase activity (GO:0051352)2.86821378
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86821378
68regulation of telomere maintenance (GO:0032204)2.86628166
69proline biosynthetic process (GO:0006561)2.86364214
70synapsis (GO:0007129)2.83743431
71sterol biosynthetic process (GO:0016126)2.83421844
72poly(A)+ mRNA export from nucleus (GO:0016973)2.83343908
73* GPI anchor metabolic process (GO:0006505)2.83093134
74kinetochore organization (GO:0051383)2.83006572
75response to interferon-beta (GO:0035456)2.82492417
76regulation of cellular amino acid metabolic process (GO:0006521)2.82053709
77pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.79476192
78tRNA aminoacylation for protein translation (GO:0006418)2.78950800
79ubiquinone metabolic process (GO:0006743)2.78884327
80deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.77823783
81mitotic recombination (GO:0006312)2.77386743
82negative regulation of mast cell activation (GO:0033004)2.74518768
83amino acid activation (GO:0043038)2.74368372
84tRNA aminoacylation (GO:0043039)2.74368372
85DNA replication initiation (GO:0006270)2.73971364
86regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.72947948
87positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.72947948
88pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.72812744
89respiratory chain complex IV assembly (GO:0008535)2.71418998
90DNA replication-dependent nucleosome organization (GO:0034723)2.70836950
91DNA replication-dependent nucleosome assembly (GO:0006335)2.70836950
92establishment of chromosome localization (GO:0051303)2.70468470
93CENP-A containing nucleosome assembly (GO:0034080)2.70210480
94spindle checkpoint (GO:0031577)2.69752034
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.68938838
96DNA double-strand break processing (GO:0000729)2.68772469
97ubiquinone biosynthetic process (GO:0006744)2.68611169
98ribosomal large subunit biogenesis (GO:0042273)2.67716920
99chaperone-mediated protein transport (GO:0072321)2.67329513
100regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.67047938
101histone exchange (GO:0043486)2.65995938
102aminoglycoside antibiotic metabolic process (GO:0030647)2.65675098
103ncRNA 3-end processing (GO:0043628)2.64931253
104regulation of double-strand break repair via homologous recombination (GO:0010569)2.64587505
105mitotic spindle checkpoint (GO:0071174)2.64460055
106DNA replication-independent nucleosome assembly (GO:0006336)2.63550967
107DNA replication-independent nucleosome organization (GO:0034724)2.63550967
108nucleotide-excision repair, DNA gap filling (GO:0006297)2.62946611
109mitotic sister chromatid segregation (GO:0000070)2.61658838
110protein K6-linked ubiquitination (GO:0085020)2.61450515
111base-excision repair (GO:0006284)2.61071736
112DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.60724486
113DNA demethylation (GO:0080111)2.60113139
114mitochondrial respiratory chain complex assembly (GO:0033108)2.59241760
115tRNA metabolic process (GO:0006399)2.58590795
116signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.58259469
117signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.58259469
118signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.58259469
119intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.57148917
120signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.57148917
121cytochrome complex assembly (GO:0017004)2.56325876
122positive regulation of ligase activity (GO:0051351)2.55125092
123lactate metabolic process (GO:0006089)2.54358532
124water-soluble vitamin biosynthetic process (GO:0042364)2.53913266
125protein localization to chromosome, centromeric region (GO:0071459)2.53076213
126DNA catabolic process, exonucleolytic (GO:0000738)2.53008071
127pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.52576688
128energy coupled proton transport, down electrochemical gradient (GO:0015985)2.51610531
129ATP synthesis coupled proton transport (GO:0015986)2.51610531
130oxidative phosphorylation (GO:0006119)2.51049791
131protein K11-linked ubiquitination (GO:0070979)2.50771501
132formation of translation preinitiation complex (GO:0001731)2.50471009
133IMP biosynthetic process (GO:0006188)2.49893464
134signal transduction involved in cell cycle checkpoint (GO:0072395)2.49690486
135pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.49226404
136DNA topological change (GO:0006265)2.49021733
137signal transduction involved in DNA integrity checkpoint (GO:0072401)2.48780516
138signal transduction involved in DNA damage checkpoint (GO:0072422)2.48780516
139* C-terminal protein lipidation (GO:0006501)2.47905245
140mitotic nuclear envelope disassembly (GO:0007077)2.47163941
141chromatin remodeling at centromere (GO:0031055)2.46719606
142pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.46474123
143replication fork processing (GO:0031297)2.46350938
144histone H4-K12 acetylation (GO:0043983)2.46108033
145pteridine-containing compound biosynthetic process (GO:0042559)2.46095287
146sister chromatid segregation (GO:0000819)2.45861751
147pseudouridine synthesis (GO:0001522)2.45839281
148transcription elongation from RNA polymerase III promoter (GO:0006385)2.45666181
149termination of RNA polymerase III transcription (GO:0006386)2.45666181
150regulation of ubiquitin-protein transferase activity (GO:0051438)2.44984484
151intraciliary transport (GO:0042073)2.43904167
152rRNA modification (GO:0000154)2.42888166
153negative regulation of sister chromatid segregation (GO:0033046)2.41426202
154negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.41426202
155negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.41426202
156negative regulation of mitotic sister chromatid segregation (GO:0033048)2.41426202
157negative regulation of mitotic sister chromatid separation (GO:2000816)2.41426202
158aldehyde catabolic process (GO:0046185)2.40870480
159regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.39827108
160GDP-mannose metabolic process (GO:0019673)2.39696279
161detection of molecule of bacterial origin (GO:0032490)2.38241108
162telomere maintenance (GO:0000723)2.37581992
163dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.36508425
164positive regulation of mitochondrial fission (GO:0090141)2.36309608
165endosome to pigment granule transport (GO:0043485)2.34930753
166endosome to melanosome transport (GO:0035646)2.34930753
167iron-sulfur cluster assembly (GO:0016226)2.34913942
168metallo-sulfur cluster assembly (GO:0031163)2.34913942
169telomere organization (GO:0032200)2.34682745
170RNA-dependent DNA replication (GO:0006278)2.34398825
171CTP metabolic process (GO:0046036)2.33481841
172CTP biosynthetic process (GO:0006241)2.33481841
173DNA dealkylation (GO:0035510)2.33402877
174meiotic chromosome segregation (GO:0045132)2.33146990
175behavioral response to nicotine (GO:0035095)2.31828627
176protein complex biogenesis (GO:0070271)2.30825736
177protein ADP-ribosylation (GO:0006471)2.30742905
178superoxide anion generation (GO:0042554)2.30513984
179establishment of integrated proviral latency (GO:0075713)2.30167314
180positive regulation by organism of defense response of other organism involved in symbiotic interact2.29932590
181modulation by symbiont of host immune response (GO:0052553)2.29932590
182positive regulation by symbiont of host defense response (GO:0052509)2.29932590
183modulation by symbiont of host defense response (GO:0052031)2.29932590
184modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.29932590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.88030438
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.70207596
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.91387330
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.85545132
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65331977
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00513916
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80030468
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.73769898
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.68559389
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.66016211
11SRF_21415370_ChIP-Seq_HL-1_Mouse2.61429514
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.60737937
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.40496294
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.36935247
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26725617
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26106766
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.15741328
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15513033
19* VDR_23849224_ChIP-Seq_CD4+_Human2.13079277
20FOXP3_21729870_ChIP-Seq_TREG_Human2.12016805
21FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.11453999
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.10170987
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09587508
24* ETS1_20019798_ChIP-Seq_JURKAT_Human2.08233129
25HOXB4_20404135_ChIP-ChIP_EML_Mouse2.05482431
26ELK1_19687146_ChIP-ChIP_HELA_Human2.03248399
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02124976
28AR_21909140_ChIP-Seq_LNCAP_Human1.98989442
29DCP1A_22483619_ChIP-Seq_HELA_Human1.98226336
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95757881
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94902068
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90317936
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88731179
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.88388335
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84550550
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84268851
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.82377923
38* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80566586
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79915359
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79763844
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79381493
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78309960
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78064763
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76021432
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72989300
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.72454094
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70667789
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.68963733
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66834292
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63082161
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62373116
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61117940
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60157991
54ZNF274_21170338_ChIP-Seq_K562_Hela1.59863269
55GBX2_23144817_ChIP-Seq_PC3_Human1.59525062
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57765748
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52833422
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52297735
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49758297
60SCL_19346495_ChIP-Seq_HPC-7_Human1.48997020
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.46601923
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45327355
63GABP_19822575_ChIP-Seq_HepG2_Human1.44099505
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43212406
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41106286
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41059677
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.35077975
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33158427
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33011797
70TTF2_22483619_ChIP-Seq_HELA_Human1.32767186
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32260448
72IRF1_19129219_ChIP-ChIP_H3396_Human1.31772326
73KDM5A_27292631_Chip-Seq_BREAST_Human1.30368039
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29873644
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28788886
76FUS_26573619_Chip-Seq_HEK293_Human1.27500319
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26601476
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23939942
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.23283720
80SPI1_23547873_ChIP-Seq_NB4_Human1.22519368
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20326242
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19405062
83ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19188137
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17672098
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.17103554
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14224620
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13847951
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13171292
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.12418870
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11982217
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11833281
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11796871
93CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10906972
94IGF1R_20145208_ChIP-Seq_DFB_Human1.10734653
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10381655
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.08477872
97NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07032205
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06911267
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06727878
100VDR_22108803_ChIP-Seq_LS180_Human1.06136068
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.05537403
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01642734
103TAL1_26923725_Chip-Seq_HPCs_Mouse1.00661994
104SOX2_16153702_ChIP-ChIP_HESCs_Human1.00308998
105SOX17_20123909_ChIP-Seq_XEN_Mouse0.99941711
106CIITA_25753668_ChIP-Seq_RAJI_Human0.99027078
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98887479
108CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98859375
109RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98075827
110SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98005085
111EWS_26573619_Chip-Seq_HEK293_Human0.96672605
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96620614
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.96251158
114POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96191393
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94901499
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94879768
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94532603
118STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94456966
119PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93390901
120MYC_18940864_ChIP-ChIP_HL60_Human0.92999052
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92877472
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92349337
123OCT4_18555785_Chip-Seq_ESCs_Mouse0.91877631
124P53_22387025_ChIP-Seq_ESCs_Mouse0.91661081
125BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91017391
126NMYC_18555785_Chip-Seq_ESCs_Mouse0.89799029
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89579246
128XRN2_22483619_ChIP-Seq_HELA_Human0.89109683
129RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87797653
130ZFX_18555785_Chip-Seq_ESCs_Mouse0.87253192
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83157040
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82828206
133EOMES_21245162_ChIP-Seq_HESCs_Human0.79453003
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78122245
135TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75950415
136FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75832296
137BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75779487
138ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75357213
139CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74533803
140CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74452575
141NANOG_21062744_ChIP-ChIP_HESCs_Human0.72812706
142CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.71135878
143RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.70308144
144TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69989059
145SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.67159649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.15283263
2MP0005171_absent_coat_pigmentation4.14021471
3MP0006292_abnormal_olfactory_placode3.83316677
4MP0004147_increased_porphyrin_level3.78218484
5MP0001188_hyperpigmentation3.59982389
6MP0009697_abnormal_copulation3.09256658
7MP0000566_synostosis3.01186806
8MP0008789_abnormal_olfactory_epithelium2.80573137
9MP0003718_maternal_effect2.73901854
10MP0008058_abnormal_DNA_repair2.73037140
11MP0009379_abnormal_foot_pigmentation2.69724652
12MP0000015_abnormal_ear_pigmentation2.63952217
13MP0008995_early_reproductive_senescence2.49475546
14MP0005394_taste/olfaction_phenotype2.48346113
15MP0005499_abnormal_olfactory_system2.48346113
16MP0003693_abnormal_embryo_hatching2.22259098
17MP0002095_abnormal_skin_pigmentation2.21624322
18MP0002938_white_spotting2.15767880
19MP0003890_abnormal_embryonic-extraembry2.13495271
20MP0001835_abnormal_antigen_presentation2.06757914
21MP0010030_abnormal_orbit_morphology2.02776754
22MP0003172_abnormal_lysosome_physiology2.02237994
23MP0008007_abnormal_cellular_replicative1.99659679
24MP0000465_gastrointestinal_hemorrhage1.97869677
25MP0002638_abnormal_pupillary_reflex1.97738875
26MP0003786_premature_aging1.94062491
27MP0000372_irregular_coat_pigmentation1.92280108
28MP0005075_abnormal_melanosome_morpholog1.89865052
29MP0010094_abnormal_chromosome_stability1.85909665
30MP0003111_abnormal_nucleus_morphology1.76720369
31MP0004782_abnormal_surfactant_physiolog1.76620879
32MP0008057_abnormal_DNA_replication1.72669066
33MP0002102_abnormal_ear_morphology1.68925399
34MP0005248_abnormal_Harderian_gland1.67648519
35MP0000490_abnormal_crypts_of1.64739479
36MP0000681_abnormal_thyroid_gland1.64187209
37MP0002233_abnormal_nose_morphology1.57760528
38MP0003567_abnormal_fetal_cardiomyocyte1.57145176
39MP0005671_abnormal_response_to1.51006296
40MP0001986_abnormal_taste_sensitivity1.50319013
41MP0002277_abnormal_respiratory_mucosa1.42629227
42MP0008875_abnormal_xenobiotic_pharmacok1.39787119
43MP0002132_abnormal_respiratory_system1.37923328
44MP0009785_altered_susceptibility_to1.37506102
45MP0005174_abnormal_tail_pigmentation1.36221733
46MP0003123_paternal_imprinting1.33634961
47MP0002148_abnormal_hypersensitivity_rea1.33344954
48MP0003077_abnormal_cell_cycle1.33195329
49MP0001293_anophthalmia1.30129571
50MP0005645_abnormal_hypothalamus_physiol1.28896035
51MP0003183_abnormal_peptide_metabolism1.28258728
52MP0001984_abnormal_olfaction1.27397891
53MP0005408_hypopigmentation1.27249788
54MP0003763_abnormal_thymus_physiology1.26073142
55MP0003937_abnormal_limbs/digits/tail_de1.25184901
56MP0006072_abnormal_retinal_apoptosis1.21256904
57MP0000678_abnormal_parathyroid_gland1.20409918
58MP0001873_stomach_inflammation1.19785823
59MP0001929_abnormal_gametogenesis1.19537899
60MP0001286_abnormal_eye_development1.19438409
61MP0004134_abnormal_chest_morphology1.19142183
62MP0004133_heterotaxia1.18111588
63MP0010386_abnormal_urinary_bladder1.17356137
64MP0002419_abnormal_innate_immunity1.14270320
65MP0001764_abnormal_homeostasis1.14130848
66MP0005646_abnormal_pituitary_gland1.14069478
67MP0001730_embryonic_growth_arrest1.12869777
68MP0002234_abnormal_pharynx_morphology1.11396453
69MP0002098_abnormal_vibrissa_morphology1.09538000
70MP0002160_abnormal_reproductive_system1.05644221
71MP0005025_abnormal_response_to1.05533850
72MP0002452_abnormal_antigen_presenting1.05158600
73MP0001672_abnormal_embryogenesis/_devel1.03302260
74MP0005380_embryogenesis_phenotype1.03302260
75MP0006036_abnormal_mitochondrial_physio1.03058453
76MP0001697_abnormal_embryo_size1.02758367
77MP0002420_abnormal_adaptive_immunity1.02613648
78MP0003315_abnormal_perineum_morphology1.02441686
79MP0006035_abnormal_mitochondrial_morpho1.01540771
80MP0000613_abnormal_salivary_gland1.01294785
81MP0001529_abnormal_vocalization1.00637853
82MP0001819_abnormal_immune_cell1.00056561
83MP0001800_abnormal_humoral_immune0.99462604
84MP0008932_abnormal_embryonic_tissue0.99407818
85MP0001324_abnormal_eye_pigmentation0.97215973
86MP0000653_abnormal_sex_gland0.97029051
87MP0001790_abnormal_immune_system0.96970538
88MP0005387_immune_system_phenotype0.96970538
89MP0002723_abnormal_immune_serum0.96700167
90MP0000358_abnormal_cell_content/0.96660119
91MP0005395_other_phenotype0.96523672
92MP0002177_abnormal_outer_ear0.96505200
93MP0005360_urolithiasis0.96496626
94MP0001145_abnormal_male_reproductive0.96165526
95MP0002398_abnormal_bone_marrow0.95972529
96MP0005084_abnormal_gallbladder_morpholo0.95746773
97MP0006276_abnormal_autonomic_nervous0.95079105
98MP0002084_abnormal_developmental_patter0.94883773
99MP0003385_abnormal_body_wall0.93335759
100MP0002139_abnormal_hepatobiliary_system0.93274963
101MP0005085_abnormal_gallbladder_physiolo0.93220993
102MP0005551_abnormal_eye_electrophysiolog0.91285026
103MP0003755_abnormal_palate_morphology0.90892117
104MP0002085_abnormal_embryonic_tissue0.90338090
105MP0003119_abnormal_digestive_system0.90056411
106MP0008877_abnormal_DNA_methylation0.89420970
107MP0001545_abnormal_hematopoietic_system0.89129822
108MP0005397_hematopoietic_system_phenotyp0.89129822
109MP0004957_abnormal_blastocyst_morpholog0.88712347
110MP0002697_abnormal_eye_size0.88660620
111MP0002080_prenatal_lethality0.88269027
112MP0003806_abnormal_nucleotide_metabolis0.88144708
113MP0000647_abnormal_sebaceous_gland0.88089521
114MP0002751_abnormal_autonomic_nervous0.87475940
115MP0003698_abnormal_male_reproductive0.86097794
116MP0002090_abnormal_vision0.85708963
117MP0000716_abnormal_immune_system0.85524178
118MP0005253_abnormal_eye_physiology0.85470129
119MP0008004_abnormal_stomach_pH0.84821111
120MP0002876_abnormal_thyroid_physiology0.84560587
121MP0005379_endocrine/exocrine_gland_phen0.84103286
122MP0006054_spinal_hemorrhage0.83433410
123MP0000516_abnormal_urinary_system0.82664499
124MP0005367_renal/urinary_system_phenotyp0.82664499
125MP0003303_peritoneal_inflammation0.82648678
126MP0005391_vision/eye_phenotype0.82523817
127MP0005410_abnormal_fertilization0.80930080
128MP0001186_pigmentation_phenotype0.80258501
129MP0003984_embryonic_growth_retardation0.80084711
130MP0000049_abnormal_middle_ear0.79599520
131MP0002429_abnormal_blood_cell0.78827244
132MP0002653_abnormal_ependyma_morphology0.78553172
133MP0003136_yellow_coat_color0.78109815
134MP0005365_abnormal_bile_salt0.78035143
135MP0002088_abnormal_embryonic_growth/wei0.77559813
136MP0003121_genomic_imprinting0.77389806
137MP0000470_abnormal_stomach_morphology0.76162223
138MP0003122_maternal_imprinting0.75956786
139MP0005000_abnormal_immune_tolerance0.75531760
140MP0002161_abnormal_fertility/fecundity0.75297291
141MP0002092_abnormal_eye_morphology0.75080257
142MP0004264_abnormal_extraembryonic_tissu0.74687396
143MP0001666_abnormal_nutrient_absorption0.74500264
144MP0002163_abnormal_gland_morphology0.74139573
145MP0001346_abnormal_lacrimal_gland0.73388510
146MP0000689_abnormal_spleen_morphology0.72952197
147MP0004043_abnormal_pH_regulation0.72605295
148MP0000350_abnormal_cell_proliferation0.72170231
149MP0005389_reproductive_system_phenotype0.71523978
150MP0010352_gastrointestinal_tract_polyps0.71517426
151MP0003195_calcinosis0.71330988
152MP0005332_abnormal_amino_acid0.71197843
153MP0003938_abnormal_ear_development0.70770102
154MP0002282_abnormal_trachea_morphology0.70133591
155MP0001664_abnormal_digestion0.69722590
156MP0003941_abnormal_skin_development0.69111464
157MP0003861_abnormal_nervous_system0.68312562
158MP0002075_abnormal_coat/hair_pigmentati0.67935834
159MP0002722_abnormal_immune_system0.67395538
160MP0004885_abnormal_endolymph0.66237404
161MP0003186_abnormal_redox_activity0.65981475
162MP0002210_abnormal_sex_determination0.65678741
163MP0000749_muscle_degeneration0.64065627
164MP0000313_abnormal_cell_death0.61716752
165MP0000631_abnormal_neuroendocrine_gland0.61584728
166MP0005409_darkened_coat_color0.60435952
167MP0001853_heart_inflammation0.58429012

Predicted human phenotypes

RankGene SetZ-score
1Cerebellar dysplasia (HP:0007033)4.46950353
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.46915049
3Chromsome breakage (HP:0040012)4.22059990
4Increased serum pyruvate (HP:0003542)3.89260705
5Abnormality of glycolysis (HP:0004366)3.87068461
6Type I transferrin isoform profile (HP:0003642)3.84847097
7Retinal dysplasia (HP:0007973)3.66747648
8Duplicated collecting system (HP:0000081)3.65306728
9Occipital encephalocele (HP:0002085)3.52494134
10Abnormality of the renal collecting system (HP:0004742)3.51170659
11Retinal atrophy (HP:0001105)3.47820652
12Type II lissencephaly (HP:0007260)3.41863260
13Stomach cancer (HP:0012126)3.40199642
14Hyperglycinemia (HP:0002154)3.38902688
15True hermaphroditism (HP:0010459)3.37318894
16Aplastic anemia (HP:0001915)3.24921739
17Acute encephalopathy (HP:0006846)3.19656815
18Tubulointerstitial nephritis (HP:0001970)3.16962877
19Pancreatic fibrosis (HP:0100732)3.01697468
20Anterior segment dysgenesis (HP:0007700)2.91654231
21Optic nerve coloboma (HP:0000588)2.90405949
22Abnormality of the labia minora (HP:0012880)2.85131468
23Increased CSF lactate (HP:0002490)2.80110550
24Neoplasm of the adrenal cortex (HP:0100641)2.73559572
25Pancreatic cysts (HP:0001737)2.70742275
26Birth length less than 3rd percentile (HP:0003561)2.70468645
27Preaxial hand polydactyly (HP:0001177)2.70190705
28Cholecystitis (HP:0001082)2.69757994
29Abnormal gallbladder physiology (HP:0012438)2.69757994
30Renal dysplasia (HP:0000110)2.68406330
31Renal cortical cysts (HP:0000803)2.66897803
32Increased hepatocellular lipid droplets (HP:0006565)2.66481535
33Hepatocellular necrosis (HP:0001404)2.65916922
34Progressive macrocephaly (HP:0004481)2.64498641
35Reticulocytopenia (HP:0001896)2.62446016
36Hepatoblastoma (HP:0002884)2.61323230
37Hepatic necrosis (HP:0002605)2.58319527
38Optic nerve hypoplasia (HP:0000609)2.57824134
39Abnormality of glycine metabolism (HP:0010895)2.48350158
40Abnormality of serine family amino acid metabolism (HP:0010894)2.48350158
41Cervical subluxation (HP:0003308)2.45708285
42Tented upper lip vermilion (HP:0010804)2.44387975
43Reduced antithrombin III activity (HP:0001976)2.42842041
44Abnormality of the heme biosynthetic pathway (HP:0010472)2.42596851
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36328028
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36328028
47Patchy hypopigmentation of hair (HP:0011365)2.35712324
48Lipid accumulation in hepatocytes (HP:0006561)2.35102896
49Abnormal biliary tract physiology (HP:0012439)2.29907607
50Bile duct proliferation (HP:0001408)2.29907607
51Cerebral edema (HP:0002181)2.28675667
52Abnormal lung lobation (HP:0002101)2.28605077
53Abnormal protein glycosylation (HP:0012346)2.28309633
54Abnormal glycosylation (HP:0012345)2.28309633
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.28309633
56Abnormal protein N-linked glycosylation (HP:0012347)2.28309633
57Methylmalonic acidemia (HP:0002912)2.27186098
58Hypoplastic pelvis (HP:0008839)2.26373650
59Progressive sensorineural hearing impairment (HP:0000408)2.26068947
60Nemaline bodies (HP:0003798)2.25769243
61Vacuolated lymphocytes (HP:0001922)2.25658627
62Hyperglycinuria (HP:0003108)2.25524967
63Abnormality of dental color (HP:0011073)2.24990193
64Horseshoe kidney (HP:0000085)2.22519433
65Abnormality of the preputium (HP:0100587)2.22282129
66White forelock (HP:0002211)2.21774185
67Medulloblastoma (HP:0002885)2.21462983
68Ectopic kidney (HP:0000086)2.21001859
69Microretrognathia (HP:0000308)2.20926154
70Supernumerary spleens (HP:0009799)2.18266177
71Abnormality of serum amino acid levels (HP:0003112)2.17143025
72Medial flaring of the eyebrow (HP:0010747)2.17124015
73Colon cancer (HP:0003003)2.16727155
74Molar tooth sign on MRI (HP:0002419)2.16407057
75Abnormality of midbrain morphology (HP:0002418)2.16407057
76Pancytopenia (HP:0001876)2.14305476
77Recurrent abscess formation (HP:0002722)2.13458756
78Bone marrow hypocellularity (HP:0005528)2.12273812
79Spinal rigidity (HP:0003306)2.11673075
80Oligodactyly (hands) (HP:0001180)2.11463590
81Easy fatigability (HP:0003388)2.11458216
82Postnatal microcephaly (HP:0005484)2.11403916
83Nephrogenic diabetes insipidus (HP:0009806)2.09644199
84Renal Fanconi syndrome (HP:0001994)2.08730329
85Type 2 muscle fiber atrophy (HP:0003554)2.08464858
86Congenital primary aphakia (HP:0007707)2.07320888
87Premature graying of hair (HP:0002216)2.06223724
88Lactic acidosis (HP:0003128)2.04727388
89Severe muscular hypotonia (HP:0006829)2.04661728
90Methylmalonic aciduria (HP:0012120)2.03535861
91Volvulus (HP:0002580)2.03328989
92Multiple enchondromatosis (HP:0005701)2.02132683
93Cystic liver disease (HP:0006706)2.01836425
94Thyroid-stimulating hormone excess (HP:0002925)2.01366347
95Cerebral hypomyelination (HP:0006808)2.00558483
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97892970
97IgM deficiency (HP:0002850)1.97794861
98Clubbing of toes (HP:0100760)1.97688473
99Abnormality of methionine metabolism (HP:0010901)1.97238949
100Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95596011
101Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95224508
102Bifid tongue (HP:0010297)1.95024065
103Gait imbalance (HP:0002141)1.94243568
104Aplasia/Hypoplasia of the uvula (HP:0010293)1.93484982
105Pancreatic islet-cell hyperplasia (HP:0004510)1.92789710
106Acute necrotizing encephalopathy (HP:0006965)1.91044365
107Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90372484
108Meckel diverticulum (HP:0002245)1.88941357
109Small intestinal stenosis (HP:0012848)1.87932375
110Duodenal stenosis (HP:0100867)1.87932375
111Hypergonadotropic hypogonadism (HP:0000815)1.87805911
112Severe visual impairment (HP:0001141)1.87312607
113Duplication of thumb phalanx (HP:0009942)1.85202020
114CNS demyelination (HP:0007305)1.84811119
115Neoplasm of the adrenal gland (HP:0100631)1.84710669
116Delayed CNS myelination (HP:0002188)1.83535329
117Nephroblastoma (Wilms tumor) (HP:0002667)1.83522212
118Abnormality of the ileum (HP:0001549)1.83242840
119Abnormality of the anterior horn cell (HP:0006802)1.82788350
120Degeneration of anterior horn cells (HP:0002398)1.82788350
121Abnormality of chromosome stability (HP:0003220)1.82137575
122Disproportionate short-trunk short stature (HP:0003521)1.81826870
123Facial cleft (HP:0002006)1.81540846
124Anophthalmia (HP:0000528)1.80819058
125Lethargy (HP:0001254)1.80376911
126Exercise intolerance (HP:0003546)1.80318118
127Abnormality of the duodenum (HP:0002246)1.79347069
128Respiratory failure (HP:0002878)1.78243122
129Recurrent bacterial skin infections (HP:0005406)1.78116670
130Vaginal atresia (HP:0000148)1.77799191
131Prolonged partial thromboplastin time (HP:0003645)1.77669355
132Embryonal renal neoplasm (HP:0011794)1.77038334
133Genital tract atresia (HP:0001827)1.76796740
134Leukodystrophy (HP:0002415)1.76406135
135Short tibia (HP:0005736)1.73820194
136Meningocele (HP:0002435)1.73582625
137Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73323077
138Absent epiphyses (HP:0010577)1.73323077
139Elevated erythrocyte sedimentation rate (HP:0003565)1.73260426
140Absent speech (HP:0001344)1.73114178
141Ependymoma (HP:0002888)1.72949638
142Optic disc pallor (HP:0000543)1.72583224
143Abnormal mitochondria in muscle tissue (HP:0008316)1.72066843
144Sloping forehead (HP:0000340)1.72060811
145Non-midline cleft lip (HP:0100335)1.71814742
146Stenosis of the external auditory canal (HP:0000402)1.71307442
147Absent septum pellucidum (HP:0001331)1.70828898
148Ulnar deviation of the wrist (HP:0003049)1.70715349
1493-Methylglutaconic aciduria (HP:0003535)1.70711609
150CNS hypomyelination (HP:0003429)1.70159410
151Muscle fiber atrophy (HP:0100295)1.69484842
152Irregular epiphyses (HP:0010582)1.69104457
153Broad alveolar ridges (HP:0000187)1.68719349
154Adrenal hypoplasia (HP:0000835)1.67028479
155Cortical dysplasia (HP:0002539)1.66505735
156Microvesicular hepatic steatosis (HP:0001414)1.65998958
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.65257428
158Increased serum lactate (HP:0002151)1.64898471
159Nasolacrimal duct obstruction (HP:0000579)1.64370076
160Abnormality of DNA repair (HP:0003254)1.63990970
161Abnormality of macrophages (HP:0004311)1.63898850
162Intestinal atresia (HP:0011100)1.63238329
163Congenital sensorineural hearing impairment (HP:0008527)1.63140672
164Myelodysplasia (HP:0002863)1.62538093
165Oligohydramnios (HP:0001562)1.61753305
166Mitochondrial inheritance (HP:0001427)1.61732840
167Septo-optic dysplasia (HP:0100842)1.61709065
168Dandy-Walker malformation (HP:0001305)1.60848764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK44.60571559
2STK163.55965636
3TRIM283.36197055
4ZAK3.20033536
5SIK32.88396040
6VRK22.73816768
7NEK12.35510320
8SRPK12.34611938
9VRK12.33853133
10WNK32.13789491
11MAP4K22.11946147
12NME22.11379187
13EIF2AK12.08023248
14MUSK1.98501892
15TXK1.84897965
16NUAK11.83907565
17BCKDK1.82631643
18CSNK1A1L1.81019075
19OBSCN1.78359243
20TEC1.77525374
21MKNK11.76520181
22CDK191.75765420
23KIT1.73828006
24IRAK31.73467969
25CSNK1G31.73409173
26PDK21.73146434
27TNIK1.67152882
28PIM21.57251566
29ADRBK21.51526125
30CCNB11.45958451
31MKNK21.44302103
32YES11.44009765
33INSRR1.39139138
34EIF2AK21.38350632
35EIF2AK31.36065512
36MAP3K41.33481545
37BRSK21.30302124
38CASK1.27855396
39ACVR1B1.24546264
40ATR1.22689076
41CSNK1G11.18900397
42EPHA21.17639089
43FLT31.15043002
44MAPK131.12867468
45CDK81.12586465
46PRKD31.12552675
47TRPM71.11822741
48FES1.08372620
49ERBB31.06692368
50BRD41.06054526
51PASK1.05724642
52PLK41.05606140
53CDC71.05515571
54MAP3K141.04013189
55PRPF4B1.02910247
56PBK1.00234931
57LIMK10.99904698
58GRK70.97797823
59NEK20.97317114
60PIK3CG0.97282664
61NME10.96172812
62TESK10.94518309
63IRAK10.92870402
64BMPR1B0.90376271
65PLK20.90048041
66BUB10.89950782
67CDK70.88981509
68BRAF0.88912803
69CSNK1G20.88909889
70BLK0.86092356
71MAPKAPK50.84605782
72RPS6KA40.83830499
73CHEK20.82155518
74BTK0.81035169
75CSF1R0.79180537
76NEK60.78970841
77ATM0.77839014
78NLK0.77407623
79SGK20.76375738
80EPHA30.76185392
81TGFBR20.76121958
82BCR0.75830650
83MET0.74959327
84MYLK0.73984209
85MAP3K120.72642559
86MAP4K10.71630003
87CLK10.69907906
88CHEK10.68554456
89WEE10.65454365
90LYN0.65104299
91MST40.63463360
92TAF10.63283653
93TTK0.63207469
94BMPR20.63102294
95GRK10.62845899
96ARAF0.62451077
97TSSK60.60426755
98MINK10.59234278
99MAP3K90.59130620
100FGFR10.58152885
101TIE10.57932373
102BRSK10.57590110
103DYRK30.57054319
104RPS6KB10.55602806
105ERBB40.55596429
106TGFBR10.54916162
107PINK10.54656784
108PLK30.54562968
109IKBKE0.53982220
110PIM10.53948707
111CAMKK20.52376511
112CDK180.51931253
113IKBKB0.51819070
114DYRK20.51787566
115CDK30.51439016
116CDK140.50313279
117CSNK2A20.49556953
118LMTK20.49297949
119EPHA40.49245388
120TESK20.49089975
121SYK0.48847636
122MAP2K70.48452508
123CDK10.48125545
124CSNK2A10.47498373
125MAPKAPK20.47097788
126STK38L0.46889375
127PIK3CA0.46131729
128CSNK1E0.46058444
129CDK11A0.45925139
130DAPK10.45365465
131PLK10.44620894
132CDK90.44208461
133ZAP700.43944983
134CDK150.42692606
135AKT30.42184124
136RPS6KB20.41455862
137MARK30.39362502
138AURKB0.39010374
139JAK30.38972141
140PAK40.38565598
141PRKCI0.38540830
142STK240.38276278
143PRKCG0.37407543
144MST1R0.37235405
145CAMK2G0.37083860
146RPS6KA60.37001927
147CDK20.36663389
148RPS6KA50.36324635
149PRKDC0.35864405
150PRKCE0.35113435
151AURKA0.34815922

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.74986923
2Protein export_Homo sapiens_hsa030603.62475065
3Mismatch repair_Homo sapiens_hsa034303.16954378
4Proteasome_Homo sapiens_hsa030502.57208425
5Homologous recombination_Homo sapiens_hsa034402.51075692
6* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.41328409
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.35415169
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.28851034
9Fanconi anemia pathway_Homo sapiens_hsa034602.24715757
10Pyrimidine metabolism_Homo sapiens_hsa002402.20552940
11Base excision repair_Homo sapiens_hsa034102.19662060
12Caffeine metabolism_Homo sapiens_hsa002322.18383613
13Non-homologous end-joining_Homo sapiens_hsa034502.17579916
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16818285
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.03101869
16Propanoate metabolism_Homo sapiens_hsa006402.03084334
17Ribosome_Homo sapiens_hsa030102.00322957
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98369123
19RNA polymerase_Homo sapiens_hsa030201.97268292
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95249962
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93090638
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.89411939
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85597794
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84007115
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.81974436
26Other glycan degradation_Homo sapiens_hsa005111.77685120
27Pyruvate metabolism_Homo sapiens_hsa006201.74524308
28Spliceosome_Homo sapiens_hsa030401.74343786
29Biosynthesis of amino acids_Homo sapiens_hsa012301.71914175
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.71302858
31RNA degradation_Homo sapiens_hsa030181.64261012
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.63179598
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.57872349
34Nucleotide excision repair_Homo sapiens_hsa034201.56483382
35N-Glycan biosynthesis_Homo sapiens_hsa005101.55234716
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.52439701
37Sphingolipid metabolism_Homo sapiens_hsa006001.52059855
38Purine metabolism_Homo sapiens_hsa002301.50571422
39Sulfur metabolism_Homo sapiens_hsa009201.49487263
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.49353458
41Carbon metabolism_Homo sapiens_hsa012001.46415598
42Cell cycle_Homo sapiens_hsa041101.41490267
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.35429577
44One carbon pool by folate_Homo sapiens_hsa006701.35357411
45Autoimmune thyroid disease_Homo sapiens_hsa053201.34962000
46Basal transcription factors_Homo sapiens_hsa030221.34924660
47RNA transport_Homo sapiens_hsa030131.33765725
48Fatty acid metabolism_Homo sapiens_hsa012121.29090660
49Measles_Homo sapiens_hsa051621.24030803
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22227372
51Butanoate metabolism_Homo sapiens_hsa006501.19306108
52Arachidonic acid metabolism_Homo sapiens_hsa005901.18614361
53Sulfur relay system_Homo sapiens_hsa041221.12982647
54Vitamin B6 metabolism_Homo sapiens_hsa007501.12617367
55NF-kappa B signaling pathway_Homo sapiens_hsa040641.12486654
56Peroxisome_Homo sapiens_hsa041461.11231680
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09965461
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08899433
59Parkinsons disease_Homo sapiens_hsa050121.08558386
60SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08311771
61Arginine and proline metabolism_Homo sapiens_hsa003301.07722985
62Hematopoietic cell lineage_Homo sapiens_hsa046401.06103771
63Oxidative phosphorylation_Homo sapiens_hsa001901.05875987
64Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05606312
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04824361
66Allograft rejection_Homo sapiens_hsa053301.04090316
67Herpes simplex infection_Homo sapiens_hsa051681.01484189
68Selenocompound metabolism_Homo sapiens_hsa004500.99787760
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.96967241
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93856273
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93823118
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.93771352
73Primary immunodeficiency_Homo sapiens_hsa053400.93163177
74Huntingtons disease_Homo sapiens_hsa050160.89196971
75Asthma_Homo sapiens_hsa053100.88120514
76Leishmaniasis_Homo sapiens_hsa051400.87720495
77Legionellosis_Homo sapiens_hsa051340.87090729
78Fatty acid degradation_Homo sapiens_hsa000710.85692050
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85601249
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84465433
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84054723
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83667070
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81928211
84Arginine biosynthesis_Homo sapiens_hsa002200.80188839
85beta-Alanine metabolism_Homo sapiens_hsa004100.79801375
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79229830
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73117419
88Renin-angiotensin system_Homo sapiens_hsa046140.72741477
89p53 signaling pathway_Homo sapiens_hsa041150.72351013
90Type I diabetes mellitus_Homo sapiens_hsa049400.70797438
91Antigen processing and presentation_Homo sapiens_hsa046120.70543422
92Fat digestion and absorption_Homo sapiens_hsa049750.69181286
93Oocyte meiosis_Homo sapiens_hsa041140.68780393
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.66044200
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65891514
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65508966
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62991808
98Pentose phosphate pathway_Homo sapiens_hsa000300.62795768
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62193050
100Fructose and mannose metabolism_Homo sapiens_hsa000510.62078265
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61722833
102Linoleic acid metabolism_Homo sapiens_hsa005910.60132976
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60130584
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59818544
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.59376534
106Graft-versus-host disease_Homo sapiens_hsa053320.58217968
107Chemical carcinogenesis_Homo sapiens_hsa052040.57179420
108Alzheimers disease_Homo sapiens_hsa050100.56911311
109Ether lipid metabolism_Homo sapiens_hsa005650.56183178
110Influenza A_Homo sapiens_hsa051640.56090480
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55975059
112Lysosome_Homo sapiens_hsa041420.54681672
113Galactose metabolism_Homo sapiens_hsa000520.53319041
114Tyrosine metabolism_Homo sapiens_hsa003500.51841053
115Circadian rhythm_Homo sapiens_hsa047100.50695241
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50300764
117Glutathione metabolism_Homo sapiens_hsa004800.50116650
118Fatty acid elongation_Homo sapiens_hsa000620.49271452
119Epstein-Barr virus infection_Homo sapiens_hsa051690.48502733
120* Metabolic pathways_Homo sapiens_hsa011000.47883438
121Tryptophan metabolism_Homo sapiens_hsa003800.47657520
122Vibrio cholerae infection_Homo sapiens_hsa051100.46680672
123Phenylalanine metabolism_Homo sapiens_hsa003600.46606421
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46001049
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44803827
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.44470088
127Retinol metabolism_Homo sapiens_hsa008300.44263202
128Steroid biosynthesis_Homo sapiens_hsa001000.43599757
129Folate biosynthesis_Homo sapiens_hsa007900.43354113
130Phagosome_Homo sapiens_hsa041450.42879262
131Collecting duct acid secretion_Homo sapiens_hsa049660.42325186
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42248562
133Regulation of autophagy_Homo sapiens_hsa041400.41082658
134Pertussis_Homo sapiens_hsa051330.40376713
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39047730
136Rheumatoid arthritis_Homo sapiens_hsa053230.38334215
137Vitamin digestion and absorption_Homo sapiens_hsa049770.35444872
138Nitrogen metabolism_Homo sapiens_hsa009100.35423329
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34985463
140mRNA surveillance pathway_Homo sapiens_hsa030150.34228743
141Lysine degradation_Homo sapiens_hsa003100.33309480
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30748256
143Starch and sucrose metabolism_Homo sapiens_hsa005000.29700842
144Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29523233
145Apoptosis_Homo sapiens_hsa042100.27923336
146Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27571936
147Jak-STAT signaling pathway_Homo sapiens_hsa046300.27035824
148HTLV-I infection_Homo sapiens_hsa051660.26616508
149Nicotine addiction_Homo sapiens_hsa050330.26326291
150Histidine metabolism_Homo sapiens_hsa003400.26058962
151Cardiac muscle contraction_Homo sapiens_hsa042600.25260931
152Hippo signaling pathway_Homo sapiens_hsa043900.24571504
153Hepatitis B_Homo sapiens_hsa051610.24305260

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