PIGV

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mannosyltransferase enzyme involved in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a complex glycolipid that functions as a membrane anchor for many proteins and plays a role in multiple cellular processes including protein sorting and signal transduction. The encoded protein is localized to the endoplasmic reticulum and transfers the second mannose to the GPI backbone. Mutations in this gene are associated with hyperphosphatasia mental retardation syndrome. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.43022825
2axon ensheathment in central nervous system (GO:0032291)9.43022825
3neutrophil activation involved in immune response (GO:0002283)5.50437262
4fatty acid elongation (GO:0030497)5.21192426
5L-amino acid import (GO:0043092)4.76915012
6amyloid precursor protein metabolic process (GO:0042982)4.67364937
7long-chain fatty acid biosynthetic process (GO:0042759)4.48715190
8eosinophil chemotaxis (GO:0048245)4.38606381
9response to redox state (GO:0051775)4.37368963
10T-helper 1 type immune response (GO:0042088)4.28970302
11regulation of pigment cell differentiation (GO:0050932)4.24059592
12myelination (GO:0042552)4.07470145
13ensheathment of neurons (GO:0007272)4.06468680
14axon ensheathment (GO:0008366)4.06468680
15amyloid precursor protein catabolic process (GO:0042987)4.04055510
16cytidine deamination (GO:0009972)3.99304844
17cytidine metabolic process (GO:0046087)3.99304844
18cytidine catabolic process (GO:0006216)3.99304844
19eosinophil migration (GO:0072677)3.92760397
20glyoxylate metabolic process (GO:0046487)3.90865173
21glycerophospholipid catabolic process (GO:0046475)3.85827314
22regulation of MHC class II biosynthetic process (GO:0045346)3.84828790
23positive regulation of macrophage differentiation (GO:0045651)3.71553827
24nucleotide transmembrane transport (GO:1901679)3.59176991
25glycosylceramide metabolic process (GO:0006677)3.55708723
26positive regulation of cellular amine metabolic process (GO:0033240)3.54826019
27eye photoreceptor cell differentiation (GO:0001754)3.53813361
28photoreceptor cell differentiation (GO:0046530)3.53813361
29negative regulation of protein localization to cell surface (GO:2000009)3.49247166
30COPI coating of Golgi vesicle (GO:0048205)3.48049765
31Golgi transport vesicle coating (GO:0048200)3.48049765
32negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.47904786
33cholesterol biosynthetic process (GO:0006695)3.47081736
34magnesium ion transport (GO:0015693)3.44712368
35negative regulation of fatty acid biosynthetic process (GO:0045717)3.41162095
36isoprenoid biosynthetic process (GO:0008299)3.36788929
37neutrophil activation (GO:0042119)3.33269356
38amino acid import (GO:0043090)3.32332857
39positive regulation of developmental pigmentation (GO:0048087)3.31458607
40positive regulation of cAMP-mediated signaling (GO:0043950)3.31232285
41L-phenylalanine metabolic process (GO:0006558)3.27451798
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.27451798
43regulation of collateral sprouting (GO:0048670)3.26174018
44signal peptide processing (GO:0006465)3.25251407
45macrophage activation involved in immune response (GO:0002281)3.24240630
46positive regulation of interleukin-17 production (GO:0032740)3.22564691
47import into cell (GO:0098657)3.22134486
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.18807210
49sexual reproduction (GO:0019953)3.18288156
50regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.17092873
51mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14470924
52sulfur amino acid catabolic process (GO:0000098)3.13657552
53* mannosylation (GO:0097502)3.13470164
54platelet dense granule organization (GO:0060155)3.12401740
55myeloid cell activation involved in immune response (GO:0002275)3.10392928
56detection of molecule of bacterial origin (GO:0032490)3.09323861
57mast cell activation (GO:0045576)3.08592608
58short-chain fatty acid metabolic process (GO:0046459)3.07804896
59peptidyl-glutamic acid carboxylation (GO:0017187)3.06172214
60protein carboxylation (GO:0018214)3.06172214
61positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.05206049
62sterol biosynthetic process (GO:0016126)3.05154557
63microglial cell activation (GO:0001774)3.04411871
64oligodendrocyte differentiation (GO:0048709)3.01863227
65granulocyte activation (GO:0036230)3.00843513
66fibrinolysis (GO:0042730)2.98417235
67negative regulation of fibrinolysis (GO:0051918)2.98143861
68positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.97369123
69establishment of mitochondrion localization (GO:0051654)2.97061526
70aldehyde catabolic process (GO:0046185)2.96920678
71pyrimidine-containing compound transmembrane transport (GO:0072531)2.95573848
72urea metabolic process (GO:0019627)2.95079496
73response to methylmercury (GO:0051597)2.92342469
74urea cycle (GO:0000050)2.91189253
75L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.90974929
76neurotransmitter uptake (GO:0001504)2.89350940
77leukocyte degranulation (GO:0043299)2.88922718
78serine family amino acid catabolic process (GO:0009071)2.86113291
79regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.84737280
80pinocytosis (GO:0006907)2.82654953
81cellular copper ion homeostasis (GO:0006878)2.82352926
82regulation of fibrinolysis (GO:0051917)2.82227837
83nitrogen cycle metabolic process (GO:0071941)2.81968793
84regulation of immunoglobulin secretion (GO:0051023)2.78586641
85positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.76626306
86developmental pigmentation (GO:0048066)2.76621611
87tissue regeneration (GO:0042246)2.72795587
88positive regulation of lipoprotein lipase activity (GO:0051006)2.72572229
89positive regulation of triglyceride lipase activity (GO:0061365)2.72572229
90regulation of protein activation cascade (GO:2000257)2.72478665
91myelin maintenance (GO:0043217)2.72270846
92positive regulation of oligodendrocyte differentiation (GO:0048714)2.70537789
93regulation of plasminogen activation (GO:0010755)2.69188914
94regulation of lymphocyte migration (GO:2000401)2.68783778
95negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.67888657
96negative regulation of cell killing (GO:0031342)2.67888657
97protein maturation by protein folding (GO:0022417)2.66939426
98detection of external biotic stimulus (GO:0098581)2.66442072
99tumor necrosis factor-mediated signaling pathway (GO:0033209)2.66411036
100negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.66379466
101epoxygenase P450 pathway (GO:0019373)2.65546998
102regulation of activation of Janus kinase activity (GO:0010533)2.65515947
103intracellular pH reduction (GO:0051452)2.65437011
104cytokine biosynthetic process (GO:0042089)2.65180908
105leukocyte migration involved in inflammatory response (GO:0002523)2.64924762
106complement activation, alternative pathway (GO:0006957)2.63768064
107glycosphingolipid catabolic process (GO:0046479)2.63730650
108L-phenylalanine catabolic process (GO:0006559)2.62889723
109erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.62889723
110mast cell degranulation (GO:0043303)2.61800201
111mast cell activation involved in immune response (GO:0002279)2.61800201
112creatine metabolic process (GO:0006600)2.61405610
113heme metabolic process (GO:0042168)2.60676646
114positive regulation by symbiont of host defense response (GO:0052509)2.60631873
115modulation by symbiont of host defense response (GO:0052031)2.60631873
116modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.60631873
117modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.60631873
118positive regulation by organism of defense response of other organism involved in symbiotic interact2.60631873
119modulation by symbiont of host immune response (GO:0052553)2.60631873
120monocyte chemotaxis (GO:0002548)2.59107945
121nucleotide transport (GO:0006862)2.57243614
122glycine metabolic process (GO:0006544)2.57002814
123long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.55559262
124positive regulation of lymphocyte migration (GO:2000403)2.53019165
125regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.52152863
126very-low-density lipoprotein particle assembly (GO:0034379)2.51378603
127protein autoprocessing (GO:0016540)2.51281451
128regulation of developmental pigmentation (GO:0048070)2.51137567
129presynaptic membrane organization (GO:0097090)2.51061546
130GDP-mannose metabolic process (GO:0019673)2.50623160
131* GPI anchor biosynthetic process (GO:0006506)2.49936617
132pH reduction (GO:0045851)2.48844905
133negative regulation of neurotransmitter transport (GO:0051589)2.48732017
134regulation of complement activation (GO:0030449)2.48578979
135L-methionine biosynthetic process (GO:0071265)2.48451181
136proline metabolic process (GO:0006560)2.47085756
137pentose metabolic process (GO:0019321)2.46165046
138negative regulation of myeloid cell apoptotic process (GO:0033033)2.44690048
139alpha-linolenic acid metabolic process (GO:0036109)2.44342776
140pentose-phosphate shunt (GO:0006098)2.43113372
141mature B cell differentiation involved in immune response (GO:0002313)2.42862507
142serine family amino acid metabolic process (GO:0009069)2.42672496
143positive regulation of T cell cytokine production (GO:0002726)2.40975274
144bile acid biosynthetic process (GO:0006699)2.38901279
1454-hydroxyproline metabolic process (GO:0019471)2.38204101
146oxaloacetate metabolic process (GO:0006107)2.36732521
147galactose catabolic process (GO:0019388)2.35086571
148hyaluronan catabolic process (GO:0030214)2.34318157
149purine nucleotide salvage (GO:0032261)2.31767665
150daunorubicin metabolic process (GO:0044597)2.30996853
151polyketide metabolic process (GO:0030638)2.30996853
152doxorubicin metabolic process (GO:0044598)2.30996853
153xenobiotic catabolic process (GO:0042178)2.30502346
154L-alpha-amino acid transmembrane transport (GO:1902475)2.29802679
155fatty acid oxidation (GO:0019395)2.27879864
156piRNA metabolic process (GO:0034587)2.27447991
157aminoglycoside antibiotic metabolic process (GO:0030647)2.27282219
158rRNA modification (GO:0000154)2.26186472
159NADPH regeneration (GO:0006740)2.25449192
160lipid oxidation (GO:0034440)2.24638102
161RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.22690872
162tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.22690872
163heme biosynthetic process (GO:0006783)2.22340121
164protoporphyrinogen IX biosynthetic process (GO:0006782)2.21567862
165regulation of interferon-beta biosynthetic process (GO:0045357)2.21486225
166oxidative demethylation (GO:0070989)2.21273702
167response to peptidoglycan (GO:0032494)2.20685564
168glucose catabolic process (GO:0006007)2.18739242
169cysteine metabolic process (GO:0006534)2.17967496
170rRNA methylation (GO:0031167)2.15593380
171fatty acid beta-oxidation (GO:0006635)2.14890853
172phenylpropanoid metabolic process (GO:0009698)2.14357526
173bile acid metabolic process (GO:0008206)2.14089851
174uronic acid metabolic process (GO:0006063)2.12534448
175glucuronate metabolic process (GO:0019585)2.12534448
176ethanol oxidation (GO:0006069)2.12418396
177positive regulation of fatty acid biosynthetic process (GO:0045723)2.12111985
178establishment of viral latency (GO:0019043)2.12027703
179regulation of lipoprotein particle clearance (GO:0010984)2.10760160
180fatty acid catabolic process (GO:0009062)2.09065717
181NIK/NF-kappaB signaling (GO:0038061)2.08969336
182nucleotide-sugar biosynthetic process (GO:0009226)2.06171966
183cellular glucuronidation (GO:0052695)2.05728734
184deoxyribose phosphate catabolic process (GO:0046386)2.04498372
185L-serine metabolic process (GO:0006563)2.03867080
186protoporphyrinogen IX metabolic process (GO:0046501)2.03271857
187negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.03075372
188COPII vesicle coating (GO:0048208)2.03045795
189carnitine metabolic process (GO:0009437)2.01471696
190regulation of superoxide anion generation (GO:0032928)2.00346853
191nucleotide salvage (GO:0043173)1.99795889

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.12691817
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.71245360
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.35241255
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.29899120
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.16631914
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.02193114
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.90649884
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.77448465
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.71073937
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.67211697
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54464668
12LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.53793033
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.51104998
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.28523515
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.26445215
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.19928010
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.19694750
18GBX2_23144817_ChIP-Seq_PC3_Human2.16940661
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.15875365
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12751623
21SCL_19346495_ChIP-Seq_HPC-7_Human2.06276484
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05683527
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01602745
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94971649
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94704694
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89189062
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88689831
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84589640
29* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84090630
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81516331
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78744641
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77736215
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71491123
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70109853
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69872318
36TFEB_21752829_ChIP-Seq_HELA_Human1.67498447
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67243365
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.64228706
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62978846
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62239323
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.62185857
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61524224
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58624630
44IRF1_19129219_ChIP-ChIP_H3396_Human1.54476824
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52763674
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52640281
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52143077
48TAF15_26573619_Chip-Seq_HEK293_Human1.52130540
49DCP1A_22483619_ChIP-Seq_HELA_Human1.51884998
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51587817
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50831441
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.47135886
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46310475
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46046983
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45379556
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.45031700
57* GABP_19822575_ChIP-Seq_HepG2_Human1.44029036
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43202640
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37895184
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37817464
61ZNF263_19887448_ChIP-Seq_K562_Human1.36858233
62* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36822635
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.36751181
64GATA1_22025678_ChIP-Seq_K562_Human1.36683947
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33895145
66* MAF_26560356_Chip-Seq_TH1_Human1.33454096
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32721264
68PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32509587
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31597502
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31534405
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.29989476
72ER_23166858_ChIP-Seq_MCF-7_Human1.29981717
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29566077
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29561906
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28926715
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28770447
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28380342
78EST1_17652178_ChIP-ChIP_JURKAT_Human1.28019109
79LXR_22158963_ChIP-Seq_LIVER_Mouse1.27696033
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26801724
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26641652
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.25752370
83FOXP3_21729870_ChIP-Seq_TREG_Human1.25744934
84* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25051669
85* VDR_23849224_ChIP-Seq_CD4+_Human1.24970743
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22987396
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22610147
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21900393
89RUNX1_27457419_Chip-Seq_LIVER_Mouse1.21580636
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21185631
91VDR_22108803_ChIP-Seq_LS180_Human1.20201344
92* UTX_26944678_Chip-Seq_JUKART_Human1.20038687
93ELK3_25401928_ChIP-Seq_HUVEC_Human1.18943101
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18556250
95SRF_21415370_ChIP-Seq_HL-1_Mouse1.18273428
96* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18189529
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.17952459
98SPI1_23547873_ChIP-Seq_NB4_Human1.17309992
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17271340
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.16797243
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.16571402
102VDR_21846776_ChIP-Seq_THP-1_Human1.16437206
103CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16152119
104KDM5A_27292631_Chip-Seq_BREAST_Human1.16021939
105* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15837727
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15681179
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15131279
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.14501898
109FUS_26573619_Chip-Seq_HEK293_Human1.14400897
110* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14215273
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.13939753
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11267870
113BCL6_27268052_Chip-Seq_Bcells_Human1.10914401
114FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10800618
115GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10512792
116EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10364047
117* MAF_26560356_Chip-Seq_TH2_Human1.10347961
118KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10225191
119XRN2_22483619_ChIP-Seq_HELA_Human1.10071318
120P300_18555785_Chip-Seq_ESCs_Mouse1.09972673
121E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09722593
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08706737
123* MYB_26560356_Chip-Seq_TH1_Human1.07954973
124P53_22387025_ChIP-Seq_ESCs_Mouse1.07919600
125* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07730959
126SMAD1_18555785_Chip-Seq_ESCs_Mouse1.07465902
127* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06562198
128BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06099422
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05974245
130FLI1_27457419_Chip-Seq_LIVER_Mouse1.05760621
131* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05632739
132CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05261701
133* RUNX1_22412390_ChIP-Seq_EML_Mouse1.05047551
134* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04828890
135SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04710867
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04428673
137PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04393157
138CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03838144
139ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03820449
140PRDM14_20953172_ChIP-Seq_ESCs_Human1.03160626
141P300_19829295_ChIP-Seq_ESCs_Human1.02458458
142GATA3_26560356_Chip-Seq_TH2_Human1.02445526
143YY1_22570637_ChIP-Seq_MALME-3M_Human1.02438897
144GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02339263
145BCOR_27268052_Chip-Seq_Bcells_Human1.01597214
146WT1_19549856_ChIP-ChIP_CCG9911_Human1.01482710
147EGR1_19374776_ChIP-ChIP_THP-1_Human1.00562735
148CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00025066
149SMAD3_21741376_ChIP-Seq_EPCs_Human0.99480715
150Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99120461
151KLF4_18555785_Chip-Seq_ESCs_Mouse0.98697390
152RUNX_20019798_ChIP-Seq_JUKART_Human0.98561419
153HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98085036
154HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97957720
155* NCOR1_26117541_ChIP-Seq_K562_Human0.97615284
156* MYB_26560356_Chip-Seq_TH2_Human0.97058801
157SOX2_19829295_ChIP-Seq_ESCs_Human0.96311526
158NANOG_19829295_ChIP-Seq_ESCs_Human0.96311526
159* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96133332
160LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95390742
161PU1_27457419_Chip-Seq_LIVER_Mouse0.93254873
162FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92735429
163ZFX_18555785_Chip-Seq_ESCs_Mouse0.92071031
164PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91870652
165CRX_20693478_ChIP-Seq_RETINA_Mouse0.90573477
166TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89898828
167CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89469536
168CTCF_18555785_Chip-Seq_ESCs_Mouse0.89392024
169SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87921114
170SOX2_18555785_Chip-Seq_ESCs_Mouse0.86759914
171STAT1_20625510_ChIP-Seq_HELA_Human0.86716338
172OCT4_18555785_Chip-Seq_ESCs_Mouse0.86160575
173CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85869323

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.82915007
2MP0002139_abnormal_hepatobiliary_system4.55069678
3MP0003806_abnormal_nucleotide_metabolis4.07810657
4MP0003690_abnormal_glial_cell3.34534273
5MP0005360_urolithiasis3.31440531
6MP0004043_abnormal_pH_regulation2.76775590
7MP0002148_abnormal_hypersensitivity_rea2.76632820
8MP0005409_darkened_coat_color2.74177482
9MP0005058_abnormal_lysosome_morphology2.64827507
10MP0006082_CNS_inflammation2.61629257
11MP0003191_abnormal_cellular_cholesterol2.58349299
12MP0005365_abnormal_bile_salt2.43154614
13MP0005671_abnormal_response_to2.41368245
14MP0003656_abnormal_erythrocyte_physiolo2.39395043
15MP0006054_spinal_hemorrhage2.28168693
16MP0000566_synostosis2.25083462
17MP0001790_abnormal_immune_system2.23504425
18MP0005387_immune_system_phenotype2.23504425
19MP0009785_altered_susceptibility_to2.22991470
20MP0008875_abnormal_xenobiotic_pharmacok2.18214497
21MP0005085_abnormal_gallbladder_physiolo2.17987982
22MP0003195_calcinosis2.13667618
23MP0002419_abnormal_innate_immunity2.07483593
24MP0003724_increased_susceptibility_to2.06376198
25MP0001835_abnormal_antigen_presentation2.04086192
26MP0003186_abnormal_redox_activity2.03883934
27MP0005000_abnormal_immune_tolerance2.02616772
28MP0009697_abnormal_copulation1.94370621
29MP0005025_abnormal_response_to1.94017399
30MP0009840_abnormal_foam_cell1.84575749
31MP0002132_abnormal_respiratory_system1.81985548
32MP0003634_abnormal_glial_cell1.79688793
33MP0001986_abnormal_taste_sensitivity1.76536325
34MP0003136_yellow_coat_color1.76464007
35MP0004147_increased_porphyrin_level1.73322977
36MP0004142_abnormal_muscle_tone1.71067921
37MP0001764_abnormal_homeostasis1.70876764
38MP0001905_abnormal_dopamine_level1.69752152
39MP0000685_abnormal_immune_system1.67055365
40MP0002723_abnormal_immune_serum1.66140988
41MP0003950_abnormal_plasma_membrane1.63492135
42MP0001529_abnormal_vocalization1.56419268
43MP0003880_abnormal_central_pattern1.55209587
44MP0003183_abnormal_peptide_metabolism1.54360809
45MP0002138_abnormal_hepatobiliary_system1.53825403
46MP0005171_absent_coat_pigmentation1.53505159
47MP0003632_abnormal_nervous_system1.53368849
48MP0000015_abnormal_ear_pigmentation1.53285925
49MP0001486_abnormal_startle_reflex1.51845882
50MP0000609_abnormal_liver_physiology1.51044480
51MP0003252_abnormal_bile_duct1.48976708
52MP0001545_abnormal_hematopoietic_system1.48257213
53MP0005397_hematopoietic_system_phenotyp1.48257213
54MP0002452_abnormal_antigen_presenting1.46659252
55MP0005451_abnormal_body_composition1.45692112
56MP0003436_decreased_susceptibility_to1.43470492
57MP0009379_abnormal_foot_pigmentation1.43320568
58MP0004381_abnormal_hair_follicle1.42195082
59MP0001485_abnormal_pinna_reflex1.40250260
60MP0002277_abnormal_respiratory_mucosa1.40012873
61MP0001800_abnormal_humoral_immune1.37406409
62MP0003303_peritoneal_inflammation1.34286426
63MP0002420_abnormal_adaptive_immunity1.32757158
64MP0005319_abnormal_enzyme/_coenzyme1.31903979
65MP0001819_abnormal_immune_cell1.31688905
66MP0005551_abnormal_eye_electrophysiolog1.31621913
67MP0003329_amyloid_beta_deposits1.31529930
68MP0003786_premature_aging1.29122210
69MP0004782_abnormal_surfactant_physiolog1.27781904
70MP0000465_gastrointestinal_hemorrhage1.27141286
71MP0005174_abnormal_tail_pigmentation1.25112798
72MP0002229_neurodegeneration1.25049654
73MP0004947_skin_inflammation1.23271502
74MP0001533_abnormal_skeleton_physiology1.23185061
75MP0006036_abnormal_mitochondrial_physio1.22416587
76MP0002933_joint_inflammation1.22141503
77MP0004134_abnormal_chest_morphology1.21417329
78MP0002272_abnormal_nervous_system1.20708873
79MP0005332_abnormal_amino_acid1.20247912
80MP0003631_nervous_system_phenotype1.20034215
81MP0004885_abnormal_endolymph1.17436357
82MP0005423_abnormal_somatic_nervous1.16394123
83MP0002722_abnormal_immune_system1.14410731
84MP0009763_increased_sensitivity_to1.11415219
85MP0009764_decreased_sensitivity_to1.10754874
86MP0000462_abnormal_digestive_system1.09466619
87MP0010329_abnormal_lipoprotein_level1.09438736
88MP0002405_respiratory_system_inflammati1.09390965
89MP0005410_abnormal_fertilization1.08980037
90MP0006035_abnormal_mitochondrial_morpho1.08321460
91MP0002118_abnormal_lipid_homeostasis1.07652633
92MP0010155_abnormal_intestine_physiology1.06013956
93MP0001666_abnormal_nutrient_absorption1.03895508
94MP0003633_abnormal_nervous_system1.03100510
95MP0002638_abnormal_pupillary_reflex1.02818668
96MP0000858_altered_metastatic_potential1.02546621
97MP0002254_reproductive_system_inflammat1.02217568
98MP0000716_abnormal_immune_system1.00774425
99MP0005584_abnormal_enzyme/coenzyme_acti1.00760227
100MP0001188_hyperpigmentation1.00649229
101MP0004742_abnormal_vestibular_system0.99957062
102MP0000598_abnormal_liver_morphology0.99654997
103MP0004185_abnormal_adipocyte_glucose0.98899765
104MP0001881_abnormal_mammary_gland0.98619885
105MP0005083_abnormal_biliary_tract0.97254125
106MP0009780_abnormal_chondrocyte_physiolo0.96794585
107MP0003172_abnormal_lysosome_physiology0.96370954
108MP0005647_abnormal_sex_gland0.95802525
109MP0009643_abnormal_urine_homeostasis0.95013672
110MP0005164_abnormal_response_to0.94823054
111MP0003868_abnormal_feces_composition0.93168511
112MP0005408_hypopigmentation0.91796096
113MP0002295_abnormal_pulmonary_circulatio0.91484599
114MP0005075_abnormal_melanosome_morpholog0.91254920
115MP0009333_abnormal_splenocyte_physiolog0.90686197
116MP0003693_abnormal_embryo_hatching0.90677110
117MP0001661_extended_life_span0.90552159
118MP0000604_amyloidosis0.90218295
119MP0002095_abnormal_skin_pigmentation0.89556188
120MP0005376_homeostasis/metabolism_phenot0.89451804
121MP0008260_abnormal_autophagy0.89307019
122MP0003075_altered_response_to0.87124299
123MP0008995_early_reproductive_senescence0.86367613
124MP0001963_abnormal_hearing_physiology0.86003746
125MP0005310_abnormal_salivary_gland0.85835095
126MP0003718_maternal_effect0.85179894
127MP0002019_abnormal_tumor_incidence0.84854389
128MP0005636_abnormal_mineral_homeostasis0.84454772
129MP0003300_gastrointestinal_ulcer0.84295388
130MP0001502_abnormal_circadian_rhythm0.83883716
131MP0001845_abnormal_inflammatory_respons0.83086431
132MP0009765_abnormal_xenobiotic_induced0.79783814
133MP0008058_abnormal_DNA_repair0.79699591
134MP0008469_abnormal_protein_level0.79396269
135MP0003111_abnormal_nucleus_morphology0.79384313
136MP0001243_abnormal_dermal_layer0.78846168
137MP0004019_abnormal_vitamin_homeostasis0.78476136
138MP0001727_abnormal_embryo_implantation0.77374187
139MP0002429_abnormal_blood_cell0.72942172
140MP0005379_endocrine/exocrine_gland_phen0.72298928
141MP0004036_abnormal_muscle_relaxation0.72125771
142MP0005195_abnormal_posterior_eye0.72006147
143MP0000689_abnormal_spleen_morphology0.69118210
144MP0002398_abnormal_bone_marrow0.68930739
145MP0000681_abnormal_thyroid_gland0.68255344
146MP0005464_abnormal_platelet_physiology0.68064204
147MP0001853_heart_inflammation0.66281680
148MP0001851_eye_inflammation0.65722848
149MP0000343_altered_response_to0.65086264
150MP0005253_abnormal_eye_physiology0.64339656
151MP0000026_abnormal_inner_ear0.63949710
152MP0003763_abnormal_thymus_physiology0.62864649
153MP0001970_abnormal_pain_threshold0.61894915
154MP0002752_abnormal_somatic_nervous0.61621179
155MP0001984_abnormal_olfaction0.60686344

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.26483634
2Deep venous thrombosis (HP:0002625)4.09244374
3Renal Fanconi syndrome (HP:0001994)4.05963651
4Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.04217358
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.00478408
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.00478408
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.94868457
8Vacuolated lymphocytes (HP:0001922)3.88920731
9Axonal loss (HP:0003447)3.84945348
10Neurofibrillary tangles (HP:0002185)3.78881298
11Parakeratosis (HP:0001036)3.76392749
12Intrahepatic cholestasis (HP:0001406)3.72714092
13Cholecystitis (HP:0001082)3.42578689
14Abnormal gallbladder physiology (HP:0012438)3.42578689
15Congenital ichthyosiform erythroderma (HP:0007431)3.17722957
16Hyperammonemia (HP:0001987)3.13077002
17Loss of speech (HP:0002371)3.09681808
18Prolonged partial thromboplastin time (HP:0003645)3.04371992
19Abnormality of pyrimidine metabolism (HP:0004353)3.03540364
20Recurrent abscess formation (HP:0002722)3.00437636
21Reduced antithrombin III activity (HP:0001976)2.98856019
22Acute necrotizing encephalopathy (HP:0006965)2.88898822
23Hepatosplenomegaly (HP:0001433)2.83993063
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.80482030
253-Methylglutaconic aciduria (HP:0003535)2.79689829
26Increased serum pyruvate (HP:0003542)2.79356305
27Abnormality of glycolysis (HP:0004366)2.79356305
28Abnormality of liposaccharide metabolism (HP:0010968)2.78009922
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.78009922
30Abnormality of glycolipid metabolism (HP:0010969)2.78009922
31Abnormal tarsal ossification (HP:0008369)2.77120396
32Abnormality of renal resorption (HP:0011038)2.74434608
33Cerebral hemorrhage (HP:0001342)2.73068607
34Gingival bleeding (HP:0000225)2.68717626
35Joint hemorrhage (HP:0005261)2.62570608
36Vertebral compression fractures (HP:0002953)2.62437385
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.62377213
38Increased serum ferritin (HP:0003281)2.60952183
39Leukodystrophy (HP:0002415)2.59592594
40Abolished electroretinogram (ERG) (HP:0000550)2.59063556
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58867617
42Increased hepatocellular lipid droplets (HP:0006565)2.57672133
43Hypoalphalipoproteinemia (HP:0003233)2.55823131
44Abnormality of the corticospinal tract (HP:0002492)2.55488238
45Prostate neoplasm (HP:0100787)2.54052358
46Stomatitis (HP:0010280)2.52478751
47Mitochondrial inheritance (HP:0001427)2.51513117
48Retinal dysplasia (HP:0007973)2.50833090
49Complement deficiency (HP:0004431)2.50716127
50Hypophosphatemic rickets (HP:0004912)2.49780640
51Osteomalacia (HP:0002749)2.48094744
52Chronic otitis media (HP:0000389)2.47747452
53Tubulointerstitial nephritis (HP:0001970)2.47650229
54Alacrima (HP:0000522)2.45042587
55* Abnormal enzyme/coenzyme activity (HP:0012379)2.44181377
56Abnormality of fatty-acid metabolism (HP:0004359)2.43844682
57Acute encephalopathy (HP:0006846)2.40099330
58Sensory axonal neuropathy (HP:0003390)2.38896959
59Prolonged neonatal jaundice (HP:0006579)2.38522639
60Partial duplication of thumb phalanx (HP:0009944)2.36273153
61Cholelithiasis (HP:0001081)2.36172459
62* Elevated alkaline phosphatase (HP:0003155)2.34761917
63Dysostosis multiplex (HP:0000943)2.34434870
64Abnormal mitochondria in muscle tissue (HP:0008316)2.33546187
65Abnormal protein glycosylation (HP:0012346)2.32034565
66Abnormal glycosylation (HP:0012345)2.32034565
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32034565
68Abnormal protein N-linked glycosylation (HP:0012347)2.32034565
69Lipid accumulation in hepatocytes (HP:0006561)2.29419580
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.26654841
71Patchy hypopigmentation of hair (HP:0011365)2.26624745
72* Abnormality of alkaline phosphatase activity (HP:0004379)2.25478735
73Increased IgM level (HP:0003496)2.25434279
74Recurrent gram-negative bacterial infections (HP:0005420)2.25145551
75Agnosia (HP:0010524)2.24353733
76Paralysis (HP:0003470)2.22180145
77Hyperglycinemia (HP:0002154)2.21083202
78Glycosuria (HP:0003076)2.18036790
79Abnormality of urine glucose concentration (HP:0011016)2.18036790
80Nausea (HP:0002018)2.17984130
81Rhabdomyolysis (HP:0003201)2.17215815
82Dicarboxylic aciduria (HP:0003215)2.16517041
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16517041
84Petechiae (HP:0000967)2.16360238
85Spastic paraparesis (HP:0002313)2.16106124
86Hypolipoproteinemia (HP:0010981)2.16099162
87Recurrent bacterial skin infections (HP:0005406)2.15422620
88Abnormal gallbladder morphology (HP:0012437)2.14144416
89Abnormality of complement system (HP:0005339)2.13611860
90Agammaglobulinemia (HP:0004432)2.13324257
91Abnormal number of erythroid precursors (HP:0012131)2.12639914
92White forelock (HP:0002211)2.11577148
93Morphological abnormality of the inner ear (HP:0011390)2.09226457
94Abnormality of macrophages (HP:0004311)2.09220364
95Mucopolysacchariduria (HP:0008155)2.09074088
96Urinary glycosaminoglycan excretion (HP:0003541)2.09074088
97Entropion (HP:0000621)2.09060834
98Abnormality of the common coagulation pathway (HP:0010990)2.07807786
99Renal cortical cysts (HP:0000803)2.07333308
100Hypobetalipoproteinemia (HP:0003563)2.07164627
101Progressive neurologic deterioration (HP:0002344)2.06887543
102Hypomagnesemia (HP:0002917)2.06470831
103Sensorimotor neuropathy (HP:0007141)2.04889618
104Premature ovarian failure (HP:0008209)2.04447452
105Decreased lacrimation (HP:0000633)2.04319746
106Exertional dyspnea (HP:0002875)2.04286187
107Anorexia (HP:0002039)2.02182096
108Abnormality of iron homeostasis (HP:0011031)2.00803610
109Rough bone trabeculation (HP:0100670)2.00274497
110Xanthomatosis (HP:0000991)2.00065069
111Duplication of thumb phalanx (HP:0009942)2.00044643
112Myositis (HP:0100614)1.98909087
113Progressive macrocephaly (HP:0004481)1.98132330
114Premature skin wrinkling (HP:0100678)1.98033098
115Cupped ear (HP:0000378)1.97939582
116Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97801278
117Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97801278
118Abnormality of polysaccharide metabolism (HP:0011012)1.97801278
119Progressive muscle weakness (HP:0003323)1.97527840
120Generalized aminoaciduria (HP:0002909)1.96587207
121Cerebral hypomyelination (HP:0006808)1.96284200
122Abnormal pupillary function (HP:0007686)1.94242316
123Abnormality of cells of the erythroid lineage (HP:0012130)1.93769867
124Poor head control (HP:0002421)1.93647458
125Severe visual impairment (HP:0001141)1.93274491
126Fatigue (HP:0012378)1.92569481
127Slow saccadic eye movements (HP:0000514)1.91827947
128Cerebral inclusion bodies (HP:0100314)1.91617800
129Myocardial infarction (HP:0001658)1.91124025
130Hyperbilirubinemia (HP:0002904)1.90135952
131* Abnormality of carpal bone ossification (HP:0006257)1.89719485
132Increased CSF lactate (HP:0002490)1.88777606
133Abnormality of glutamine family amino acid metabolism (HP:0010902)1.88587712
134Flat acetabular roof (HP:0003180)1.87316032
135Reticulocytosis (HP:0001923)1.87138380
136Basal ganglia calcification (HP:0002135)1.86929772
137Purpura (HP:0000979)1.85899893
138Aplasia involving bones of the extremities (HP:0009825)1.85825967
139Aplasia involving bones of the upper limbs (HP:0009823)1.85825967
140Aplasia of the phalanges of the hand (HP:0009802)1.85825967
141IgG deficiency (HP:0004315)1.85625966
142Methylmalonic acidemia (HP:0002912)1.83127170
143Partial duplication of the phalanx of hand (HP:0009999)1.82793664
144Epistaxis (HP:0000421)1.82750570
145Spontaneous abortion (HP:0005268)1.82415577
146Beaking of vertebral bodies (HP:0004568)1.81764038
147Abnormality of nucleobase metabolism (HP:0010932)1.81567282
148Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81025945
149Systemic lupus erythematosus (HP:0002725)1.80760959
150Supranuclear gaze palsy (HP:0000605)1.80392906
151Orchitis (HP:0100796)1.79927151
152Peripheral hypomyelination (HP:0007182)1.78760848
153Asplenia (HP:0001746)1.78612842
154Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77801550
155Hepatocellular necrosis (HP:0001404)1.77798468
156Stomach cancer (HP:0012126)1.77037829
157Abnormality of magnesium homeostasis (HP:0004921)1.76822038
158Abnormality of the fetal cardiovascular system (HP:0010948)1.76151072
159Abnormal umbilical cord blood vessels (HP:0011403)1.76151072
160Single umbilical artery (HP:0001195)1.76151072
161Exercise intolerance (HP:0003546)1.75435493
162Fat malabsorption (HP:0002630)1.75135008
163Abnormal trabecular bone morphology (HP:0100671)1.74355554
164Episodic fever (HP:0001954)1.74292519
165Metabolic acidosis (HP:0001942)1.73424292
166Neutropenia (HP:0001875)1.72822631
167Hypertriglyceridemia (HP:0002155)1.71540742
168Thyroid-stimulating hormone excess (HP:0002925)1.71199017
169Recurrent bronchitis (HP:0002837)1.71069017
170Diaphragmatic weakness (HP:0009113)1.69925512
171Urticaria (HP:0001025)1.69556953
172Vaginal atresia (HP:0000148)1.69050113
173Abnormality of the heme biosynthetic pathway (HP:0010472)1.68766474
174Progressive external ophthalmoplegia (HP:0000590)1.67967209
175Type I transferrin isoform profile (HP:0003642)1.67808202
176Metabolic alkalosis (HP:0200114)1.66297145
177Medial flaring of the eyebrow (HP:0010747)1.66044491
178Conical tooth (HP:0000698)1.66011210
179Spontaneous hematomas (HP:0007420)1.64311915
180Abnormal drinking behavior (HP:0030082)1.63543954
181Polydipsia (HP:0001959)1.63543954
182Optic disc pallor (HP:0000543)1.63381571
183Conjugated hyperbilirubinemia (HP:0002908)1.62343523
184Abnormality of the renal collecting system (HP:0004742)1.62295446
185Rectal fistula (HP:0100590)1.62240870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B5.26154499
2MST44.92364281
3TESK24.07466579
4STK393.92353091
5TNIK3.87148817
6ERN13.73136383
7TESK13.51250072
8PIM23.42145407
9EPHB12.87347783
10NME22.69946534
11ARAF2.48071894
12OXSR12.42575662
13STK162.22766371
14TBK12.08356250
15MAPK152.03843959
16MAP3K31.93121925
17PKN11.82506863
18MAPKAPK51.82393383
19MUSK1.82392191
20PLK41.76082473
21BLK1.75782664
22PBK1.71031925
23VRK21.70996482
24SCYL21.63905054
25VRK11.57465259
26LIMK11.56134180
27TAOK21.55520097
28MAP2K31.47808516
29MAP3K141.44891606
30CLK11.44853583
31MST1R1.42771471
32TGFBR11.41528520
33CDK191.40546402
34DYRK31.39441666
35EIF2AK31.38182290
36EPHA21.37169262
37BTK1.34256725
38MATK1.33913045
39NEK11.30221951
40RAF11.29514142
41WNK41.29279716
42EPHB21.28302569
43WNK31.28052809
44TEC1.27945208
45IRAK31.26197145
46TYK21.26190920
47GRK61.23320161
48YES11.22809840
49MAP3K111.21256144
50NEK61.20819461
51ACVR1B1.19748297
52TXK1.17511837
53EIF2AK11.15696333
54STK101.15021629
55MAP2K21.12068994
56CDK91.10938258
57PAK41.08797875
58CASK1.08660386
59IRAK41.08078988
60TLK11.08017307
61MKNK11.07404678
62NUAK11.05708481
63ITK1.02529653
64CSNK1A1L0.98491650
65TRPM70.96546184
66MKNK20.95075391
67TTK0.94251044
68GRK70.93094492
69GRK10.92254547
70KIT0.90976361
71CAMK2B0.90163335
72CSK0.90033465
73INSRR0.89332127
74ZAP700.89294220
75CSNK1G30.89284828
76CAMK2D0.87501180
77WNK10.85934438
78LCK0.85280812
79MAP3K120.84863528
80BCR0.84201542
81NEK90.83755231
82TNK20.83381734
83LYN0.81467441
84ADRBK20.81382148
85PIK3CA0.80831022
86CDK70.80237035
87CDK80.80008670
88LRRK20.78973590
89MAP4K10.78795179
90BCKDK0.77642067
91UHMK10.77455559
92PRKCQ0.76351335
93FGR0.75413889
94RPS6KB20.74970252
95TAOK10.73940805
96SMG10.73749359
97ZAK0.71976524
98MAPK110.71382743
99DYRK20.70627397
100IRAK10.69492867
101AURKA0.68244239
102MET0.67239764
103PRKCI0.66879803
104BMPR20.65779401
105SGK4940.64893696
106SGK2230.64893696
107IKBKB0.64893409
108NLK0.63195996
109KDR0.63132439
110CSF1R0.63051686
111HCK0.63022137
112MARK20.62944933
113SYK0.62401635
114STK40.60885261
115MAP3K80.60658370
116TAOK30.59954570
117CSNK1G10.58983250
118DAPK10.58346566
119PRPF4B0.58311559
120BRAF0.57065058
121BUB10.56776620
122PIM10.56450724
123NEK20.55478260
124GSK3A0.54591815
125SIK10.54425110
126CCNB10.54189706
127PIK3CG0.53938304
128OBSCN0.53878733
129IRAK20.53732452
130NME10.53210332
131MYLK0.53084089
132RPS6KA50.52707470
133MAPKAPK30.52183368
134ABL20.51599800
135PAK10.51552942
136PRKCE0.51456693
137FGFR20.50988635
138TGFBR20.50232105
139ROCK20.49880184
140MAP3K10.48356470
141DDR20.48080848
142SRPK10.47929782
143PINK10.46612381
144EIF2AK20.46446389
145FES0.46150844
146MAPKAPK20.46000548
147JAK10.44963730
148IKBKE0.44689073
149PRKG10.44428792
150BMX0.42800786
151CAMK2G0.42336036
152FYN0.41476642
153HIPK20.41305942
154MAPK130.41031621
155JAK20.40669913
156PKN20.39271663
157FLT30.39079454
158JAK30.38483058
159MOS0.36786048
160PRKCD0.36376727
161TRIB30.36205782
162MAP4K20.35991760
163MAPK120.35550689
164PRKD10.35012454
165CSNK1G20.34505199
166CAMK2A0.32703617

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.55865958
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.29477773
3Protein export_Homo sapiens_hsa030603.50588850
4Fatty acid elongation_Homo sapiens_hsa000623.42586596
5Sulfur metabolism_Homo sapiens_hsa009203.31036942
6Steroid biosynthesis_Homo sapiens_hsa001003.10710945
7Histidine metabolism_Homo sapiens_hsa003402.60645820
8Ether lipid metabolism_Homo sapiens_hsa005652.59971711
9Oxidative phosphorylation_Homo sapiens_hsa001902.54089157
10Sulfur relay system_Homo sapiens_hsa041222.38594088
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.30245449
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28799121
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10257566
14Sphingolipid metabolism_Homo sapiens_hsa006002.02427056
15Allograft rejection_Homo sapiens_hsa053302.01279088
16Other glycan degradation_Homo sapiens_hsa005111.92143563
17Complement and coagulation cascades_Homo sapiens_hsa046101.86211660
18Parkinsons disease_Homo sapiens_hsa050121.79677219
19Rheumatoid arthritis_Homo sapiens_hsa053231.76725039
20* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73411893
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.72840876
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.72100171
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72016176
24Graft-versus-host disease_Homo sapiens_hsa053321.70376031
25Biosynthesis of amino acids_Homo sapiens_hsa012301.69710734
26Fatty acid degradation_Homo sapiens_hsa000711.69163779
27Ribosome_Homo sapiens_hsa030101.65661961
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.63494278
29Proteasome_Homo sapiens_hsa030501.62178787
30Fatty acid metabolism_Homo sapiens_hsa012121.59706666
31Alzheimers disease_Homo sapiens_hsa050101.59631951
32Lysosome_Homo sapiens_hsa041421.57665806
33Arginine biosynthesis_Homo sapiens_hsa002201.54254767
34Carbon metabolism_Homo sapiens_hsa012001.50754978
35Linoleic acid metabolism_Homo sapiens_hsa005911.47812681
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.46770631
37Arachidonic acid metabolism_Homo sapiens_hsa005901.43748713
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41885268
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33650654
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32936963
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30396593
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.28099088
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27295934
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26777664
45Base excision repair_Homo sapiens_hsa034101.24912258
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24564395
47Pentose phosphate pathway_Homo sapiens_hsa000301.24496061
48Galactose metabolism_Homo sapiens_hsa000521.23058423
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22361427
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20281137
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19362337
52Fructose and mannose metabolism_Homo sapiens_hsa000511.19177764
53Autoimmune thyroid disease_Homo sapiens_hsa053201.18969568
54Staphylococcus aureus infection_Homo sapiens_hsa051501.18354382
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15480215
56Peroxisome_Homo sapiens_hsa041461.14737531
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14241640
58Malaria_Homo sapiens_hsa051441.10190554
59Arginine and proline metabolism_Homo sapiens_hsa003301.08672834
60Cyanoamino acid metabolism_Homo sapiens_hsa004601.08433899
61Glutathione metabolism_Homo sapiens_hsa004801.08180750
62Huntingtons disease_Homo sapiens_hsa050161.07345853
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07289586
64Type I diabetes mellitus_Homo sapiens_hsa049401.06846502
65SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06291713
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05932962
67NF-kappa B signaling pathway_Homo sapiens_hsa040641.05322884
68beta-Alanine metabolism_Homo sapiens_hsa004101.03780472
69Propanoate metabolism_Homo sapiens_hsa006401.03550248
70Pyruvate metabolism_Homo sapiens_hsa006201.03033367
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99944900
72Nucleotide excision repair_Homo sapiens_hsa034200.99390367
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99266189
74Caffeine metabolism_Homo sapiens_hsa002320.98966760
75Fatty acid biosynthesis_Homo sapiens_hsa000610.98143100
76ABC transporters_Homo sapiens_hsa020100.96823766
77Collecting duct acid secretion_Homo sapiens_hsa049660.96418421
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95127988
79PPAR signaling pathway_Homo sapiens_hsa033200.94093200
80Vibrio cholerae infection_Homo sapiens_hsa051100.93484962
81Primary immunodeficiency_Homo sapiens_hsa053400.92187101
82Phagosome_Homo sapiens_hsa041450.91676514
83Chemical carcinogenesis_Homo sapiens_hsa052040.88503700
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88456339
85Vitamin digestion and absorption_Homo sapiens_hsa049770.87887876
86Asthma_Homo sapiens_hsa053100.85539408
87Starch and sucrose metabolism_Homo sapiens_hsa005000.84838615
88Pertussis_Homo sapiens_hsa051330.83372553
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82237426
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80313423
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79631604
92Folate biosynthesis_Homo sapiens_hsa007900.78583052
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78119685
94Glycerolipid metabolism_Homo sapiens_hsa005610.75450717
95DNA replication_Homo sapiens_hsa030300.74969650
96Homologous recombination_Homo sapiens_hsa034400.74818324
97* Metabolic pathways_Homo sapiens_hsa011000.71318498
98Chemokine signaling pathway_Homo sapiens_hsa040620.70096345
99Hematopoietic cell lineage_Homo sapiens_hsa046400.69825689
100African trypanosomiasis_Homo sapiens_hsa051430.69238931
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.68259254
102Vitamin B6 metabolism_Homo sapiens_hsa007500.68037592
103Tyrosine metabolism_Homo sapiens_hsa003500.61987034
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61799732
105Serotonergic synapse_Homo sapiens_hsa047260.59074040
106Butanoate metabolism_Homo sapiens_hsa006500.57649894
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54201689
108Measles_Homo sapiens_hsa051620.52924664
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51006095
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50068687
111RNA polymerase_Homo sapiens_hsa030200.49332537
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49206201
113Phototransduction_Homo sapiens_hsa047440.46885403
114TNF signaling pathway_Homo sapiens_hsa046680.45710395
115Shigellosis_Homo sapiens_hsa051310.44156810
116N-Glycan biosynthesis_Homo sapiens_hsa005100.43344362
117Osteoclast differentiation_Homo sapiens_hsa043800.43257747
118Pyrimidine metabolism_Homo sapiens_hsa002400.43051746
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.41184333
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40727436
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40314766
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39627109
123Leishmaniasis_Homo sapiens_hsa051400.38779795
124Hepatitis C_Homo sapiens_hsa051600.38697065
125Non-homologous end-joining_Homo sapiens_hsa034500.38638065
126Tryptophan metabolism_Homo sapiens_hsa003800.38388812
127Tuberculosis_Homo sapiens_hsa051520.36465397
128Phenylalanine metabolism_Homo sapiens_hsa003600.33577395
129Systemic lupus erythematosus_Homo sapiens_hsa053220.33430428
130Antigen processing and presentation_Homo sapiens_hsa046120.33068166
131p53 signaling pathway_Homo sapiens_hsa041150.32874696
132Retinol metabolism_Homo sapiens_hsa008300.32833645
133Influenza A_Homo sapiens_hsa051640.32592913
134Fanconi anemia pathway_Homo sapiens_hsa034600.32577608
135Herpes simplex infection_Homo sapiens_hsa051680.32085429
136One carbon pool by folate_Homo sapiens_hsa006700.31700244
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30468925
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29293288
139Mineral absorption_Homo sapiens_hsa049780.26442523
140Cardiac muscle contraction_Homo sapiens_hsa042600.26364404
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24396073
142Glutamatergic synapse_Homo sapiens_hsa047240.23730093
143Regulation of autophagy_Homo sapiens_hsa041400.23317510
144Legionellosis_Homo sapiens_hsa051340.22843280
145Mismatch repair_Homo sapiens_hsa034300.22146130

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