PIGW

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an inositol acyltransferase that acylates the inositol ring of phosphatidylinositol. This occurs in the endoplasmic reticulum and is a step in the biosynthesis of glycosylphosphatidylinositol (GPI), which anchors many cell surface proteins to the membrane. Defects in this gene are a cause of West syndrome and hyperphosphatasia with mental retardation syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)4.92243387
2proteasome assembly (GO:0043248)4.52617637
3valine metabolic process (GO:0006573)4.30216756
4establishment of integrated proviral latency (GO:0075713)4.13561742
5chromatin remodeling at centromere (GO:0031055)4.07035544
6DNA unwinding involved in DNA replication (GO:0006268)4.04250020
7CENP-A containing nucleosome assembly (GO:0034080)3.98886907
8ribosomal small subunit assembly (GO:0000028)3.89715770
9mitotic metaphase plate congression (GO:0007080)3.73862972
10DNA double-strand break processing (GO:0000729)3.72629085
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.72585402
12glycine metabolic process (GO:0006544)3.62789672
13regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.62117056
14IMP biosynthetic process (GO:0006188)3.61287500
15maturation of 5.8S rRNA (GO:0000460)3.52330140
16histone exchange (GO:0043486)3.51667332
17folic acid metabolic process (GO:0046655)3.51423850
18cullin deneddylation (GO:0010388)3.51421352
19rRNA modification (GO:0000154)3.51103840
20anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.49023412
21maturation of SSU-rRNA (GO:0030490)3.48576774
22positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.47149776
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.45136796
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.44779890
25negative regulation of ligase activity (GO:0051352)3.44779890
26DNA replication-dependent nucleosome organization (GO:0034723)3.44677950
27DNA replication-dependent nucleosome assembly (GO:0006335)3.44677950
28nuclear pore complex assembly (GO:0051292)3.44565890
29nucleobase biosynthetic process (GO:0046112)3.43110168
30tRNA aminoacylation for protein translation (GO:0006418)3.43019548
31amino acid activation (GO:0043038)3.41691468
32tRNA aminoacylation (GO:0043039)3.41691468
33mitochondrial RNA metabolic process (GO:0000959)3.39030251
34tetrahydrofolate metabolic process (GO:0046653)3.37329976
35one-carbon metabolic process (GO:0006730)3.35734521
36serine family amino acid biosynthetic process (GO:0009070)3.34054958
37protein localization to kinetochore (GO:0034501)3.32602801
38cysteine metabolic process (GO:0006534)3.32224908
39protein deneddylation (GO:0000338)3.31968314
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.30303422
41regulation of mitotic spindle checkpoint (GO:1903504)3.30303422
42regulation of translational fidelity (GO:0006450)3.29851282
43mitotic nuclear envelope disassembly (GO:0007077)3.28686941
44regulation of mitochondrial translation (GO:0070129)3.28562536
45IMP metabolic process (GO:0046040)3.28441721
46metaphase plate congression (GO:0051310)3.27824499
47somatic hypermutation of immunoglobulin genes (GO:0016446)3.26557433
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26557433
49mitotic sister chromatid segregation (GO:0000070)3.26271951
50nuclear pore organization (GO:0006999)3.25618977
51L-serine metabolic process (GO:0006563)3.22983617
52DNA replication-independent nucleosome organization (GO:0034724)3.22357087
53DNA replication-independent nucleosome assembly (GO:0006336)3.22357087
54DNA catabolic process, exonucleolytic (GO:0000738)3.20615832
55DNA strand elongation involved in DNA replication (GO:0006271)3.20231087
56DNA replication initiation (GO:0006270)3.19389465
57termination of RNA polymerase III transcription (GO:0006386)3.17746706
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.17746706
59purine nucleobase biosynthetic process (GO:0009113)3.17442373
60peptidyl-histidine modification (GO:0018202)3.16544882
61DNA damage response, detection of DNA damage (GO:0042769)3.16472186
62double-strand break repair via nonhomologous end joining (GO:0006303)3.13455040
63non-recombinational repair (GO:0000726)3.13455040
64regulation of cellular amino acid metabolic process (GO:0006521)3.13187904
65serine family amino acid metabolic process (GO:0009069)3.10323139
66spliceosomal snRNP assembly (GO:0000387)3.09669353
67positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09030778
68translational termination (GO:0006415)3.08492835
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.07676732
70kinetochore organization (GO:0051383)3.07598428
71spindle checkpoint (GO:0031577)3.07326295
72establishment of viral latency (GO:0019043)3.06962246
73rRNA methylation (GO:0031167)3.05287350
74sister chromatid segregation (GO:0000819)3.04770417
75antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.04013858
76antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.04013858
77regulation of centriole replication (GO:0046599)3.03898686
78ribosome assembly (GO:0042255)3.03299107
79pteridine-containing compound biosynthetic process (GO:0042559)3.02802979
80DNA strand elongation (GO:0022616)3.02691491
81DNA ligation (GO:0006266)3.02651562
82signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.01337431
83signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.01337431
84signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.01337431
85protein K6-linked ubiquitination (GO:0085020)3.00964287
86viral transcription (GO:0019083)3.00460636
87membrane disassembly (GO:0030397)2.98978700
88nuclear envelope disassembly (GO:0051081)2.98978700
89positive regulation of ligase activity (GO:0051351)2.98379829
90mitotic sister chromatid cohesion (GO:0007064)2.97859862
91regulation of DNA endoreduplication (GO:0032875)2.97824823
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97157266
93intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.96894354
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.96894354
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96465352
96oxaloacetate metabolic process (GO:0006107)2.95870497
97folic acid-containing compound metabolic process (GO:0006760)2.95704815
98mitotic spindle checkpoint (GO:0071174)2.95669924
99dosage compensation (GO:0007549)2.95553058
100establishment of protein localization to mitochondrial membrane (GO:0090151)2.95207733
101signal transduction involved in DNA damage checkpoint (GO:0072422)2.93583309
102signal transduction involved in DNA integrity checkpoint (GO:0072401)2.93583309
103translational elongation (GO:0006414)2.92586193
104ribosomal large subunit biogenesis (GO:0042273)2.92460216
105regulation of ubiquitin-protein transferase activity (GO:0051438)2.92379150
106replication fork processing (GO:0031297)2.90716527
107signal transduction involved in cell cycle checkpoint (GO:0072395)2.89242925
108G1/S transition of mitotic cell cycle (GO:0000082)2.88236930
109cell cycle G1/S phase transition (GO:0044843)2.88236930
110exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87614637
111RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87461533
112DNA deamination (GO:0045006)2.86920808
113negative regulation of chromosome segregation (GO:0051985)2.86699947
114negative regulation of sister chromatid segregation (GO:0033046)2.85981066
115negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85981066
116negative regulation of RNA splicing (GO:0033119)2.85819400
117positive regulation of gamma-delta T cell activation (GO:0046645)2.85089725
118lysine metabolic process (GO:0006553)2.83188315
119lysine catabolic process (GO:0006554)2.83188315
120regulation of gamma-delta T cell differentiation (GO:0045586)2.83163673
121regulation of translational termination (GO:0006449)2.82072503
122pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.75784176
123UMP biosynthetic process (GO:0006222)2.75784176
124pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.75784176
125UMP metabolic process (GO:0046049)2.75784176
126translational initiation (GO:0006413)2.75124461
127pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.72363240
128protein localization to chromosome, centromeric region (GO:0071459)2.68878316
129formation of translation preinitiation complex (GO:0001731)2.68465383
130pore complex assembly (GO:0046931)2.66419847
131telomere maintenance via semi-conservative replication (GO:0032201)2.64713754
132translesion synthesis (GO:0019985)2.64290126
133nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.63663777
1342-oxoglutarate metabolic process (GO:0006103)2.62858575
135pseudouridine synthesis (GO:0001522)2.62289039
136negative regulation of mRNA processing (GO:0050686)2.62101059
137nucleoside salvage (GO:0043174)2.61987568
138ribonucleoprotein complex biogenesis (GO:0022613)2.61856022
139ribosome biogenesis (GO:0042254)2.59331523
140mitotic G1 DNA damage checkpoint (GO:0031571)2.58187004
141triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.57748417
142negative regulation of fatty acid biosynthetic process (GO:0045717)2.55919409
143DNA duplex unwinding (GO:0032508)2.52046314
144pentose-phosphate shunt (GO:0006098)2.51479940
145regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.49129913
146DNA geometric change (GO:0032392)2.49117566
147antigen processing and presentation of endogenous antigen (GO:0019883)2.48964599
148DNA replication checkpoint (GO:0000076)2.48782692
149negative regulation of translational initiation (GO:0045947)2.48485952
150SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.47273159
151ribosomal small subunit biogenesis (GO:0042274)2.46772137
152response to nitrosative stress (GO:0051409)2.43478178
153rRNA processing (GO:0006364)2.41507271
154glyoxylate metabolic process (GO:0046487)2.40080073
155negative regulation of sterol transport (GO:0032372)2.39055599
156negative regulation of cholesterol transport (GO:0032375)2.39055599
157S-adenosylmethionine metabolic process (GO:0046500)2.38679059
158pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.38641624
159pteridine-containing compound metabolic process (GO:0042558)2.38588129
160negative regulation of mRNA metabolic process (GO:1903312)2.38424681
161somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.38235739
162isotype switching (GO:0045190)2.38235739
163somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.38235739
164protein targeting to ER (GO:0045047)2.37251079
165telomere maintenance via recombination (GO:0000722)2.34927216
166rRNA metabolic process (GO:0016072)2.34340856
167cotranslational protein targeting to membrane (GO:0006613)2.33980225
168NADPH regeneration (GO:0006740)2.33902982
169regulation of gamma-delta T cell activation (GO:0046643)2.32065759
170nuclear envelope organization (GO:0006998)2.32009711
171establishment of protein localization to endoplasmic reticulum (GO:0072599)2.31654154
172T cell apoptotic process (GO:0070231)2.31625819
173erythrocyte maturation (GO:0043249)2.30759400
174tricarboxylic acid metabolic process (GO:0072350)2.30594420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.39826700
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.87496291
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.73852994
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.16735499
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.84068676
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72736358
7MYC_22102868_ChIP-Seq_BL_Human2.71266726
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.60852416
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.53346103
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51405702
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34245647
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32899632
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28311437
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23704185
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.20047795
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06322759
17PADI4_21655091_ChIP-ChIP_MCF-7_Human2.02061688
18RXR_22158963_ChIP-Seq_LIVER_Mouse1.96728704
19TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.95722650
20NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95666971
21PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94742044
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93741593
23XRN2_22483619_ChIP-Seq_HELA_Human1.90328292
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89320175
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.88409821
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.86577090
27AR_21909140_ChIP-Seq_LNCAP_Human1.82182385
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.80645891
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78723173
30FOXP3_21729870_ChIP-Seq_TREG_Human1.77787199
31* GABP_17652178_ChIP-ChIP_JURKAT_Human1.77236318
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74056437
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72426796
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.71110506
35GATA1_22025678_ChIP-Seq_K562_Human1.70021076
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68299966
37VDR_23849224_ChIP-Seq_CD4+_Human1.66978235
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66858112
39MYC_18940864_ChIP-ChIP_HL60_Human1.66818756
40VDR_21846776_ChIP-Seq_THP-1_Human1.64087727
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63156350
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62964279
43ZNF274_21170338_ChIP-Seq_K562_Hela1.61569021
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61436485
45* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61296125
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59138388
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58995548
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57679819
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57474873
50* DCP1A_22483619_ChIP-Seq_HELA_Human1.57066182
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.56275742
52CIITA_25753668_ChIP-Seq_RAJI_Human1.55452264
53* NOTCH1_21737748_ChIP-Seq_TLL_Human1.51351220
54GABP_19822575_ChIP-Seq_HepG2_Human1.51311621
55* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49618507
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48418536
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48414708
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47793928
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47200335
60EWS_26573619_Chip-Seq_HEK293_Human1.45538676
61KDM5A_27292631_Chip-Seq_BREAST_Human1.44825874
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43494658
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43465955
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41642141
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41466191
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41064401
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40942464
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40295043
69* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39840176
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37155208
71ELK1_19687146_ChIP-ChIP_HELA_Human1.30505341
72MAF_26560356_Chip-Seq_TH1_Human1.25665010
73FUS_26573619_Chip-Seq_HEK293_Human1.25361085
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25278465
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.24561220
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24491709
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24221866
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23927617
79UTX_26944678_Chip-Seq_JUKART_Human1.22882630
80* TTF2_22483619_ChIP-Seq_HELA_Human1.22797968
81SCL_19346495_ChIP-Seq_HPC-7_Human1.21289645
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20616253
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20132069
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19290119
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18733884
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17888007
87* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16247972
88* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15993604
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15885795
90MYB_26560356_Chip-Seq_TH1_Human1.15753316
91TFEB_21752829_ChIP-Seq_HELA_Human1.15138048
92LXR_22158963_ChIP-Seq_LIVER_Mouse1.14657241
93TCF7_22412390_ChIP-Seq_EML_Mouse1.13797113
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.12912339
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12584447
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11369087
97VDR_22108803_ChIP-Seq_LS180_Human1.11237552
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10895358
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10819469
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10320283
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.09514249
102* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09434678
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09422633
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09196110
105SPI1_23547873_ChIP-Seq_NB4_Human1.08978061
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06988119
107MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06170183
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04996606
109MYB_26560356_Chip-Seq_TH2_Human1.04645384
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03657275
111THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03227589
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03170683
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02274734
114GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01552837
115* RUNX1_22412390_ChIP-Seq_EML_Mouse1.00745367
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00401567
117HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98525288
118SRF_21415370_ChIP-Seq_HL-1_Mouse0.98484320
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.98134571
120ELK1_22589737_ChIP-Seq_MCF10A_Human0.96082393
121STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95472754
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95219564
123SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93839187
124TP63_19390658_ChIP-ChIP_HaCaT_Human0.87079785
125SOX2_16153702_ChIP-ChIP_HESCs_Human0.86714403
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85665189
127SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84461198
128ELF5_23300383_ChIP-Seq_T47D_Human0.82685256
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82074805
130POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81845200
131CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79281827
132POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79275172
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77207057
134PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74004071
135CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.72830030
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.71076352
137CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.70427835
138RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.69354144
139CHD1_26751641_Chip-Seq_LNCaP_Human0.69089763
140IRF1_19129219_ChIP-ChIP_H3396_Human0.68171522
141TBX5_21415370_ChIP-Seq_HL-1_Mouse0.68056099

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.36431803
2MP0005360_urolithiasis3.23259497
3MP0002396_abnormal_hematopoietic_system2.77628206
4MP0005365_abnormal_bile_salt2.76160996
5MP0003806_abnormal_nucleotide_metabolis2.69792567
6MP0005085_abnormal_gallbladder_physiolo2.68367357
7MP0003693_abnormal_embryo_hatching2.63396556
8MP0010094_abnormal_chromosome_stability2.44896176
9MP0010352_gastrointestinal_tract_polyps2.32246568
10MP0004957_abnormal_blastocyst_morpholog2.26044091
11MP0000372_irregular_coat_pigmentation2.26027401
12MP0008057_abnormal_DNA_replication2.19009252
13MP0008877_abnormal_DNA_methylation2.15313243
14MP0003718_maternal_effect2.10710948
15MP0003111_abnormal_nucleus_morphology2.08522377
16MP0006054_spinal_hemorrhage2.06879602
17MP0004808_abnormal_hematopoietic_stem2.06858055
18MP0003705_abnormal_hypodermis_morpholog2.04874064
19MP0009697_abnormal_copulation2.03996082
20MP0003077_abnormal_cell_cycle1.99806684
21MP0003656_abnormal_erythrocyte_physiolo1.89568651
22MP0003252_abnormal_bile_duct1.89038645
23MP0009840_abnormal_foam_cell1.84279100
24MP0006035_abnormal_mitochondrial_morpho1.83229666
25MP0005408_hypopigmentation1.79697856
26MP0001545_abnormal_hematopoietic_system1.74870812
27MP0005397_hematopoietic_system_phenotyp1.74870812
28MP0003890_abnormal_embryonic-extraembry1.72325860
29MP0003763_abnormal_thymus_physiology1.70060269
30MP0000685_abnormal_immune_system1.68602742
31MP0010234_abnormal_vibrissa_follicle1.65690918
32MP0003937_abnormal_limbs/digits/tail_de1.63948649
33MP0008875_abnormal_xenobiotic_pharmacok1.57856795
34MP0004147_increased_porphyrin_level1.55502549
35MP0000609_abnormal_liver_physiology1.54773343
36MP0003941_abnormal_skin_development1.54418411
37MP0001529_abnormal_vocalization1.52327039
38MP0008058_abnormal_DNA_repair1.50888889
39MP0000689_abnormal_spleen_morphology1.49023552
40MP0001293_anophthalmia1.46303206
41MP0002398_abnormal_bone_marrow1.45666190
42MP0010307_abnormal_tumor_latency1.43794447
43MP0003300_gastrointestinal_ulcer1.40364033
44MP0002938_white_spotting1.40127688
45MP0002722_abnormal_immune_system1.38694845
46MP0000490_abnormal_crypts_of1.38676086
47MP0002084_abnormal_developmental_patter1.38264981
48MP0010329_abnormal_lipoprotein_level1.36844182
49MP0001188_hyperpigmentation1.35419745
50MP0008789_abnormal_olfactory_epithelium1.35041667
51MP0002102_abnormal_ear_morphology1.34900419
52MP0000358_abnormal_cell_content/1.34767543
53MP0008007_abnormal_cellular_replicative1.33341873
54MP0003186_abnormal_redox_activity1.32264612
55MP0003136_yellow_coat_color1.30758203
56MP0002160_abnormal_reproductive_system1.30568622
57MP0003221_abnormal_cardiomyocyte_apopto1.29315959
58MP0000703_abnormal_thymus_morphology1.29022231
59MP0002166_altered_tumor_susceptibility1.28354861
60MP0001853_heart_inflammation1.27861467
61MP0009333_abnormal_splenocyte_physiolog1.26213110
62MP0001800_abnormal_humoral_immune1.24602507
63MP0001730_embryonic_growth_arrest1.23987520
64MP0009053_abnormal_anal_canal1.23227014
65MP0002254_reproductive_system_inflammat1.22618347
66MP0000598_abnormal_liver_morphology1.22122968
67MP0000350_abnormal_cell_proliferation1.22059832
68MP0002019_abnormal_tumor_incidence1.20865623
69MP0002085_abnormal_embryonic_tissue1.20702488
70MP0005319_abnormal_enzyme/_coenzyme1.17821586
71MP0005464_abnormal_platelet_physiology1.17242781
72MP0001764_abnormal_homeostasis1.16175790
73MP0006036_abnormal_mitochondrial_physio1.15240979
74MP0002210_abnormal_sex_determination1.12145769
75MP0003191_abnormal_cellular_cholesterol1.11610739
76MP0003303_peritoneal_inflammation1.11579747
77MP0004197_abnormal_fetal_growth/weight/1.11402187
78MP0005023_abnormal_wound_healing1.11043287
79MP0005083_abnormal_biliary_tract1.10476867
80MP0002086_abnormal_extraembryonic_tissu1.09145019
81MP0010155_abnormal_intestine_physiology1.09031703
82MP0005394_taste/olfaction_phenotype1.08981128
83MP0005499_abnormal_olfactory_system1.08981128
84MP0005076_abnormal_cell_differentiation1.08171294
85MP0004133_heterotaxia1.07948377
86MP0002429_abnormal_blood_cell1.07517085
87MP0001661_extended_life_span1.06705564
88MP0003984_embryonic_growth_retardation1.06029884
89MP0009672_abnormal_birth_weight1.05975807
90MP0002736_abnormal_nociception_after1.05785347
91MP0001929_abnormal_gametogenesis1.05384360
92MP0006072_abnormal_retinal_apoptosis1.04278534
93MP0001666_abnormal_nutrient_absorption1.03987836
94MP0002088_abnormal_embryonic_growth/wei1.03165732
95MP0000647_abnormal_sebaceous_gland1.02136786
96MP0000313_abnormal_cell_death1.01616428
97MP0000716_abnormal_immune_system1.01474872
98MP0003868_abnormal_feces_composition1.00719879
99MP0001915_intracranial_hemorrhage1.00689724
100MP0001697_abnormal_embryo_size1.00414032
101MP0004233_abnormal_muscle_weight1.00153031
102MP0001672_abnormal_embryogenesis/_devel1.00077930
103MP0005380_embryogenesis_phenotype1.00077930
104MP0001984_abnormal_olfaction0.99858668
105MP0002877_abnormal_melanocyte_morpholog0.97793073
106MP0002080_prenatal_lethality0.97719008
107MP0003123_paternal_imprinting0.97443915
108MP0005389_reproductive_system_phenotype0.95399124
109MP0005332_abnormal_amino_acid0.94953603
110MP0001873_stomach_inflammation0.94712715
111MP0002723_abnormal_immune_serum0.93717997
112MP0002452_abnormal_antigen_presenting0.93531915
113MP0010368_abnormal_lymphatic_system0.93446784
114MP0003121_genomic_imprinting0.93393479
115MP0000465_gastrointestinal_hemorrhage0.92137015
116MP0001835_abnormal_antigen_presentation0.91856721
117MP0002233_abnormal_nose_morphology0.91552982
118MP0005387_immune_system_phenotype0.91388753
119MP0001790_abnormal_immune_system0.91388753
120MP0005187_abnormal_penis_morphology0.90639589
121MP0004130_abnormal_muscle_cell0.90396729
122MP0002163_abnormal_gland_morphology0.90236070
123MP0003567_abnormal_fetal_cardiomyocyte0.88621317
124MP0002420_abnormal_adaptive_immunity0.88598760
125MP0000427_abnormal_hair_cycle0.88203950
126MP0008932_abnormal_embryonic_tissue0.87338967
127MP0001145_abnormal_male_reproductive0.86781546
128MP0005075_abnormal_melanosome_morpholog0.86472174
129MP0002111_abnormal_tail_morphology0.86313626
130MP0001819_abnormal_immune_cell0.86114546
131MP0003119_abnormal_digestive_system0.85928488
132MP0002006_tumorigenesis0.85140764
133MP0005671_abnormal_response_to0.84951335
134MP0005584_abnormal_enzyme/coenzyme_acti0.84731089
135MP0002138_abnormal_hepatobiliary_system0.84111067
136MP0003195_calcinosis0.84097799
137MP0000653_abnormal_sex_gland0.83368755
138MP0009278_abnormal_bone_marrow0.83226589
139MP0003755_abnormal_palate_morphology0.83115777
140MP0008469_abnormal_protein_level0.82591926
141MP0003436_decreased_susceptibility_to0.81612088
142MP0004215_abnormal_myocardial_fiber0.80626143
143MP0005220_abnormal_exocrine_pancreas0.80538116
144MP0003786_premature_aging0.79782020
145MP0001919_abnormal_reproductive_system0.79780129
146MP0006292_abnormal_olfactory_placode0.79525087
147MP0000858_altered_metastatic_potential0.79056394
148MP0005666_abnormal_adipose_tissue0.78428667
149MP0002090_abnormal_vision0.77842564
150MP0009703_decreased_birth_body0.77492816
151MP0005379_endocrine/exocrine_gland_phen0.76894714
152MP0008995_early_reproductive_senescence0.76381197
153MP0003943_abnormal_hepatobiliary_system0.75688194
154MP0005084_abnormal_gallbladder_morpholo0.75466101
155MP0001845_abnormal_inflammatory_respons0.75186768
156MP0002118_abnormal_lipid_homeostasis0.73587548
157MP0000015_abnormal_ear_pigmentation0.73585331
158MP0005253_abnormal_eye_physiology0.73520848
159MP0003566_abnormal_cell_adhesion0.72757922
160MP0002697_abnormal_eye_size0.72169283
161MP0002095_abnormal_skin_pigmentation0.72048265
162MP0005171_absent_coat_pigmentation0.65994731
163MP0001727_abnormal_embryo_implantation0.65542009
164MP0001286_abnormal_eye_development0.65394726
165MP0002177_abnormal_outer_ear0.63637197
166MP0008872_abnormal_physiological_respon0.62861742

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84202404
2Chromsome breakage (HP:0040012)3.67007719
3Hypobetalipoproteinemia (HP:0003563)3.64548775
4Thrombocytosis (HP:0001894)3.61273703
5Entropion (HP:0000621)3.29960011
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.19858762
7Abnormality of alanine metabolism (HP:0010916)3.19858762
8Hyperalaninemia (HP:0003348)3.19858762
9Deep venous thrombosis (HP:0002625)3.15982923
10Meckel diverticulum (HP:0002245)3.11703967
11Intrahepatic cholestasis (HP:0001406)3.03765621
12Abnormality of the ileum (HP:0001549)3.01180175
13Abnormality of chromosome stability (HP:0003220)2.99417693
14Abnormality of glycolysis (HP:0004366)2.97295114
15Abnormality of the preputium (HP:0100587)2.97017141
16Poikiloderma (HP:0001029)2.94765942
17Increased serum pyruvate (HP:0003542)2.94168642
18Abnormality of monocarboxylic acid metabolism (HP:0010996)2.93030095
19Xanthomatosis (HP:0000991)2.92418432
20Abnormality of the heme biosynthetic pathway (HP:0010472)2.89035539
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.84141965
22Acute necrotizing encephalopathy (HP:0006965)2.75544300
23Abnormal lung lobation (HP:0002101)2.69441665
24Acute encephalopathy (HP:0006846)2.68226254
25Hypokinesia (HP:0002375)2.66831406
26Myocardial infarction (HP:0001658)2.64215139
27Abnormality of the labia minora (HP:0012880)2.64132690
28Increased CSF lactate (HP:0002490)2.62417184
29Spastic diplegia (HP:0001264)2.56910691
30Lipid accumulation in hepatocytes (HP:0006561)2.55535794
31Type I transferrin isoform profile (HP:0003642)2.52766494
32Abnormal protein glycosylation (HP:0012346)2.52744756
33Abnormal glycosylation (HP:0012345)2.52744756
34Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.52744756
35Abnormal protein N-linked glycosylation (HP:0012347)2.52744756
36Increased serum lactate (HP:0002151)2.52262027
37Acanthocytosis (HP:0001927)2.48587440
38Abnormality of cells of the erythroid lineage (HP:0012130)2.47314107
39Abnormal platelet volume (HP:0011876)2.46991005
40Neoplasm of the adrenal gland (HP:0100631)2.46681297
41Abnormal mitochondria in muscle tissue (HP:0008316)2.45134028
42Abnormality of aromatic amino acid family metabolism (HP:0004338)2.43560969
43Hypolipoproteinemia (HP:0010981)2.43358727
44Increased mean platelet volume (HP:0011877)2.43313653
45Increased hepatocellular lipid droplets (HP:0006565)2.43140550
46Multiple enchondromatosis (HP:0005701)2.42676320
47Abnormality of the common coagulation pathway (HP:0010990)2.39630867
48Small intestinal stenosis (HP:0012848)2.36538818
49Duodenal stenosis (HP:0100867)2.36538818
50Global brain atrophy (HP:0002283)2.36470928
51Squamous cell carcinoma (HP:0002860)2.35946456
52Ependymoma (HP:0002888)2.35872509
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.34323027
54Abnormal number of erythroid precursors (HP:0012131)2.33432610
55Abnormality of pyrimidine metabolism (HP:0004353)2.32448510
56Progressive macrocephaly (HP:0004481)2.32091507
57Horseshoe kidney (HP:0000085)2.31940788
58Sloping forehead (HP:0000340)2.30332717
59Hyperlipoproteinemia (HP:0010980)2.28015332
60Hyperammonemia (HP:0001987)2.25997222
61Mitochondrial inheritance (HP:0001427)2.21006684
62Abnormality of the intrinsic pathway (HP:0010989)2.20517734
63Abnormal platelet function (HP:0011869)2.20175318
64Impaired platelet aggregation (HP:0003540)2.20175318
65Reduced subcutaneous adipose tissue (HP:0003758)2.19744388
66Abnormality of sulfur amino acid metabolism (HP:0004339)2.17522635
67Hepatocellular necrosis (HP:0001404)2.15711699
68Abnormality of fatty-acid metabolism (HP:0004359)2.15636223
69Cerebral edema (HP:0002181)2.15039061
70Reticulocytosis (HP:0001923)2.14785733
71Hyperbilirubinemia (HP:0002904)2.14726098
72Abnormality of reticulocytes (HP:0004312)2.14582290
73Reticulocytopenia (HP:0001896)2.14220613
74Poikilocytosis (HP:0004447)2.11693171
75Hypoglycemic coma (HP:0001325)2.11114441
76Degeneration of anterior horn cells (HP:0002398)2.11110795
77Abnormality of the anterior horn cell (HP:0006802)2.11110795
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11069773
79Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11069773
80Hyperacusis (HP:0010780)2.09421015
81Hepatic necrosis (HP:0002605)2.05691640
82Polycythemia (HP:0001901)2.05484995
83Neoplasm of the adrenal cortex (HP:0100641)2.03912035
84Epidermoid cyst (HP:0200040)2.03872857
85Glioma (HP:0009733)2.02539682
86Abnormality of the duodenum (HP:0002246)2.02461160
87Birth length less than 3rd percentile (HP:0003561)2.02393867
88Abnormal cartilage morphology (HP:0002763)2.01608309
89Postnatal microcephaly (HP:0005484)2.01231165
90Abnormal foot bone ossification (HP:0010675)2.00749714
91Nephroblastoma (Wilms tumor) (HP:0002667)1.99941854
92Absent radius (HP:0003974)1.98441748
93Hypoplasia of the pons (HP:0012110)1.97704661
94Thoracic kyphosis (HP:0002942)1.96748994
95Lactic acidosis (HP:0003128)1.95685544
96Embryonal renal neoplasm (HP:0011794)1.95511995
97Reduced antithrombin III activity (HP:0001976)1.95213464
98Prolonged bleeding time (HP:0003010)1.94271747
99Testicular atrophy (HP:0000029)1.93354198
10011 pairs of ribs (HP:0000878)1.91852702
101Abnormality of the thoracic spine (HP:0100711)1.90566944
102Basal cell carcinoma (HP:0002671)1.90376517
103Cerebral hypomyelination (HP:0006808)1.90357130
104Chronic otitis media (HP:0000389)1.90181528
105Microvesicular hepatic steatosis (HP:0001414)1.89671465
106Amaurosis fugax (HP:0100576)1.89641346
107Nausea (HP:0002018)1.89564727
108Neoplasm of the colon (HP:0100273)1.88491626
109Colon cancer (HP:0003003)1.88331538
110Oral leukoplakia (HP:0002745)1.88260153
111Astrocytoma (HP:0009592)1.87340232
112Abnormality of the astrocytes (HP:0100707)1.87340232
113Abnormality of aspartate family amino acid metabolism (HP:0010899)1.87217506
114Deviation of the thumb (HP:0009603)1.87209917
115Cutaneous melanoma (HP:0012056)1.87031091
116Abnormality of the carotid arteries (HP:0005344)1.86851798
117Bifid tongue (HP:0010297)1.86847244
118T lymphocytopenia (HP:0005403)1.86800145
119Hypercholesterolemia (HP:0003124)1.86505339
120Abnormality of serum amino acid levels (HP:0003112)1.86473423
121Absent forearm bone (HP:0003953)1.85689063
122Aplasia involving forearm bones (HP:0009822)1.85689063
123Pancreatic islet-cell hyperplasia (HP:0004510)1.85651580
124Epistaxis (HP:0000421)1.85027652
125Areflexia of lower limbs (HP:0002522)1.84786772
126Rhabdomyolysis (HP:0003201)1.84496313
127Mesomelia (HP:0003027)1.84003348
128Abnormality of iron homeostasis (HP:0011031)1.83276795
129Aplasia/hypoplasia of the uterus (HP:0008684)1.83118015
130Progressive muscle weakness (HP:0003323)1.82959896
131Proximal placement of thumb (HP:0009623)1.82322855
132Protrusio acetabuli (HP:0003179)1.81817989
133Hepatocellular carcinoma (HP:0001402)1.81168616
134Abnormality of the pons (HP:0007361)1.80479345
135Pallor (HP:0000980)1.80450824
136Hyperglycinemia (HP:0002154)1.80198555
137Progressive inability to walk (HP:0002505)1.80149907
138Methylmalonic acidemia (HP:0002912)1.78942036
139Abnormality of methionine metabolism (HP:0010901)1.78790271
140Prolonged partial thromboplastin time (HP:0003645)1.78445720
141Volvulus (HP:0002580)1.77802714
142Cortical dysplasia (HP:0002539)1.77705690
143Increased nuchal translucency (HP:0010880)1.77690417
144Congenital stationary night blindness (HP:0007642)1.77182906
145Increased serum ferritin (HP:0003281)1.77070345
146Medulloblastoma (HP:0002885)1.76981605
147Pancreatic cysts (HP:0001737)1.76771262
148Hypoplasia of the thymus (HP:0000778)1.76340926
149Increased density of long bones (HP:0006392)1.76321344
150IgM deficiency (HP:0002850)1.74945509
151Pancytopenia (HP:0001876)1.74314025
152Adenoma sebaceum (HP:0009720)1.74236303
153Angiofibromas (HP:0010615)1.74236303
154Abnormality of the fingertips (HP:0001211)1.74011886
155Rhabdomyosarcoma (HP:0002859)1.73819324
156Toxemia of pregnancy (HP:0100603)1.72957338
157Severe short stature (HP:0003510)1.72090371
158Acute myeloid leukemia (HP:0004808)1.71189735
159Ectopic kidney (HP:0000086)1.71066987
160Clubbing of toes (HP:0100760)1.70826840
161Cholelithiasis (HP:0001081)1.69683236
162Selective tooth agenesis (HP:0001592)1.69405527
163Adrenal hypoplasia (HP:0000835)1.69348577
164Urethral obstruction (HP:0000796)1.68090145
165Fat malabsorption (HP:0002630)1.68067133
166Pendular nystagmus (HP:0012043)1.67551400
167Hypoalphalipoproteinemia (HP:0003233)1.67338528
168Lymphoma (HP:0002665)1.66338094
169Renal cortical cysts (HP:0000803)1.66280278
170Molar tooth sign on MRI (HP:0002419)1.66249447
171Abnormality of midbrain morphology (HP:0002418)1.66249447
172Methylmalonic aciduria (HP:0012120)1.66230650
173Rough bone trabeculation (HP:0100670)1.66149426
174Pancreatic fibrosis (HP:0100732)1.65359790
175Abnormality of T cells (HP:0002843)1.64743140
176Abnormal tarsal ossification (HP:0008369)1.64567638
177Abnormality of T cell number (HP:0011839)1.63853345
178Facial cleft (HP:0002006)1.63574064
179Megaloblastic anemia (HP:0001889)1.63112260
180Combined immunodeficiency (HP:0005387)1.62859450
181Myelodysplasia (HP:0002863)1.62622603
182High pitched voice (HP:0001620)1.61608858
183Complement deficiency (HP:0004431)1.61326025
184Microretrognathia (HP:0000308)1.61045535
185Sparse eyelashes (HP:0000653)1.60980864
1863-Methylglutaconic aciduria (HP:0003535)1.60210309
187Palpitations (HP:0001962)1.58227601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.74982663
2NME23.33989680
3MAP4K12.95421006
4EEF2K2.70830411
5TRIM282.66925848
6CDC72.66496032
7EIF2AK12.43095286
8PBK2.34629846
9CDK122.27335955
10FLT32.25152065
11MAP3K102.20220899
12PDK22.14484004
13PLK32.13429572
14TNIK2.05499539
15MST42.04583320
16VRK22.00553120
17STK101.95202889
18TRIB31.85225564
19SCYL21.79183572
20RPS6KB21.76690745
21EIF2AK31.73439698
22STK161.69092176
23TGFBR11.64835036
24MAP2K31.63630061
25NUAK11.62054368
26ACVR1B1.61135216
27LRRK21.60242033
28RPS6KA41.56951956
29CDK41.54899771
30ZAP701.50340758
31WNK31.47054752
32BMPR1B1.45392234
33PASK1.43730311
34PTK61.42008357
35TTN1.38143731
36WEE11.37134206
37ERN11.36747580
38BCR1.35009419
39NEK21.34843805
40TEC1.30016697
41BTK1.28804402
42TSSK61.28257171
43ATR1.25682559
44JAK31.25637427
45NME11.24586927
46MAP4K21.22239317
47TYK21.20057875
48TAF11.19784079
49MAP3K81.19644576
50SRPK11.19206361
51WNK41.17540931
52BRD41.14239215
53GRK61.10867834
54MAP3K141.08933847
55BCKDK1.08590334
56STK38L1.06515838
57ERBB31.05358284
58BRSK11.04301077
59EIF2AK21.01959066
60CDK61.01727561
61STK390.99487358
62CHEK20.99183781
63PNCK0.97794978
64PIM10.97639496
65ALK0.97570942
66AURKB0.97453250
67KDR0.97064868
68NEK10.94644739
69LATS10.93798470
70CDK70.91548589
71CSF1R0.91383754
72FGFR40.91143834
73MAP3K120.89684403
74CSNK1G10.89042481
75PAK20.88144022
76TLK10.86934712
77MAP3K70.84726749
78CSNK1G30.80294652
79CASK0.77911708
80BUB10.77638149
81TAOK20.77472057
82CAMK1D0.76624010
83ERBB40.75967710
84MAP2K70.75218607
85ITK0.75151964
86CHEK10.73718306
87PDK40.72127354
88PDK30.72127354
89PLK20.70616912
90NLK0.70523166
91MAP3K30.69566627
92SIK30.69470291
93KIT0.69087460
94CSNK1A1L0.68587017
95PAK40.68533417
96SIK10.67211816
97FGFR10.66847898
98PLK10.66816458
99TAOK10.65946263
100CSNK1G20.65200856
101JAK20.65113040
102MKNK10.64247265
103MTOR0.62255555
104TXK0.61814235
105SYK0.60896574
106ATM0.59437780
107STK40.58240849
108STK30.57244517
109BRSK20.56649200
110TTK0.56051555
111JAK10.55993438
112PRKCI0.54860673
113MAP2K60.54791454
114MELK0.52854256
115MST1R0.52008624
116TRPM70.51612044
117CDK20.51498741
118CSNK2A20.50957033
119NEK90.50783871
120OXSR10.50435478
121CCNB10.49046742
122PLK40.48510512
123CSNK2A10.48349757
124CDK80.48017135
125VRK10.47243898
126CDK30.46969028
127AURKA0.46943618
128NTRK30.46397129
129CDK10.45656836
130CLK10.45591935
131MAP3K40.45480205
132BLK0.45152786
133ZAK0.44568336
134TBK10.43384308
135AKT20.42382077
136PIM20.41926460
137MKNK20.41408043
138RAF10.40971497
139CSNK1E0.40853007
140LYN0.40218341
141DYRK30.39285326
142TGFBR20.39030503
143GRK10.38053551
144FRK0.37630813
145LCK0.37110517
146MINK10.36796492
147DAPK10.36092376
148IRAK30.33262620
149BRAF0.32797543
150RPS6KA50.32152506
151LIMK10.31106849
152PRKDC0.28524349
153EPHA20.27735323
154DYRK20.26290715
155ADRBK20.25903875

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.00935393
2One carbon pool by folate_Homo sapiens_hsa006702.87889373
3Protein export_Homo sapiens_hsa030602.68138888
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50644102
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.27073577
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.27035464
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14397170
8Mismatch repair_Homo sapiens_hsa034302.11367423
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.11063991
10Caffeine metabolism_Homo sapiens_hsa002321.99547239
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98153871
12Ribosome_Homo sapiens_hsa030101.93671384
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.88436699
14Cysteine and methionine metabolism_Homo sapiens_hsa002701.84273436
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82456790
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.81897066
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80912436
18RNA transport_Homo sapiens_hsa030131.80756205
19Biosynthesis of amino acids_Homo sapiens_hsa012301.79328178
20Selenocompound metabolism_Homo sapiens_hsa004501.70956512
21Base excision repair_Homo sapiens_hsa034101.70830937
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68720310
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66831321
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63223865
25Spliceosome_Homo sapiens_hsa030401.63202546
26Carbon metabolism_Homo sapiens_hsa012001.56966852
27Oxidative phosphorylation_Homo sapiens_hsa001901.53053005
28Fatty acid degradation_Homo sapiens_hsa000711.52512910
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50363592
30Nucleotide excision repair_Homo sapiens_hsa034201.43174430
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40998326
32Pentose phosphate pathway_Homo sapiens_hsa000301.38886359
33Parkinsons disease_Homo sapiens_hsa050121.34327842
34Non-homologous end-joining_Homo sapiens_hsa034501.34081719
35Pyrimidine metabolism_Homo sapiens_hsa002401.33070907
36Pyruvate metabolism_Homo sapiens_hsa006201.31133424
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30347204
38Steroid biosynthesis_Homo sapiens_hsa001001.29225412
39Cell cycle_Homo sapiens_hsa041101.25958487
40Arginine biosynthesis_Homo sapiens_hsa002201.25720052
41Folate biosynthesis_Homo sapiens_hsa007901.22519648
42Propanoate metabolism_Homo sapiens_hsa006401.20539233
43Lysine degradation_Homo sapiens_hsa003101.17222869
44Fatty acid elongation_Homo sapiens_hsa000621.14265537
45Sulfur relay system_Homo sapiens_hsa041221.13568374
46Huntingtons disease_Homo sapiens_hsa050161.13250711
47* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11448742
48Nitrogen metabolism_Homo sapiens_hsa009101.10265543
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10224619
50Complement and coagulation cascades_Homo sapiens_hsa046101.07698905
51RNA polymerase_Homo sapiens_hsa030201.05337620
52Vitamin B6 metabolism_Homo sapiens_hsa007501.04198056
53RNA degradation_Homo sapiens_hsa030181.04039274
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02398740
55Tryptophan metabolism_Homo sapiens_hsa003800.97733505
56Primary immunodeficiency_Homo sapiens_hsa053400.96776965
57p53 signaling pathway_Homo sapiens_hsa041150.96742373
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96557944
59Herpes simplex infection_Homo sapiens_hsa051680.93535477
60PPAR signaling pathway_Homo sapiens_hsa033200.90201859
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89131003
62Proteasome_Homo sapiens_hsa030500.84779747
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82666703
64Peroxisome_Homo sapiens_hsa041460.82236006
65Chronic myeloid leukemia_Homo sapiens_hsa052200.80740679
66Fatty acid metabolism_Homo sapiens_hsa012120.80624861
67Acute myeloid leukemia_Homo sapiens_hsa052210.79894598
68Homologous recombination_Homo sapiens_hsa034400.79479883
69Butanoate metabolism_Homo sapiens_hsa006500.79451836
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77331538
71Oocyte meiosis_Homo sapiens_hsa041140.77304469
72B cell receptor signaling pathway_Homo sapiens_hsa046620.77277601
73Systemic lupus erythematosus_Homo sapiens_hsa053220.75670055
74* Metabolic pathways_Homo sapiens_hsa011000.71228312
75Small cell lung cancer_Homo sapiens_hsa052220.71062407
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.67853233
77Viral carcinogenesis_Homo sapiens_hsa052030.67362830
78Alzheimers disease_Homo sapiens_hsa050100.66637555
79Starch and sucrose metabolism_Homo sapiens_hsa005000.66438592
80beta-Alanine metabolism_Homo sapiens_hsa004100.65745931
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65208315
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64756504
83Antigen processing and presentation_Homo sapiens_hsa046120.64203452
84HTLV-I infection_Homo sapiens_hsa051660.63422875
85Chemical carcinogenesis_Homo sapiens_hsa052040.61695695
86mRNA surveillance pathway_Homo sapiens_hsa030150.61494021
87Legionellosis_Homo sapiens_hsa051340.61345489
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.61195127
89Thyroid cancer_Homo sapiens_hsa052160.60893200
90Staphylococcus aureus infection_Homo sapiens_hsa051500.60533796
91Epstein-Barr virus infection_Homo sapiens_hsa051690.59668443
92Glutathione metabolism_Homo sapiens_hsa004800.58842040
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58046452
94N-Glycan biosynthesis_Homo sapiens_hsa005100.56676920
95Hepatitis B_Homo sapiens_hsa051610.56065864
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.54698050
97Measles_Homo sapiens_hsa051620.53579299
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53578438
99Sulfur metabolism_Homo sapiens_hsa009200.53376412
100Fanconi anemia pathway_Homo sapiens_hsa034600.53121189
101T cell receptor signaling pathway_Homo sapiens_hsa046600.51530003
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.50436014
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49810295
104Basal transcription factors_Homo sapiens_hsa030220.48755467
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48021254
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45945737
107Phototransduction_Homo sapiens_hsa047440.45672983
108Apoptosis_Homo sapiens_hsa042100.44927137
109Insulin resistance_Homo sapiens_hsa049310.42387781
110TGF-beta signaling pathway_Homo sapiens_hsa043500.41140534
111ABC transporters_Homo sapiens_hsa020100.41132582
112Fat digestion and absorption_Homo sapiens_hsa049750.40747335
113Hematopoietic cell lineage_Homo sapiens_hsa046400.40427764
114Arginine and proline metabolism_Homo sapiens_hsa003300.39364698
115Purine metabolism_Homo sapiens_hsa002300.38476776
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.37777579
117Phenylalanine metabolism_Homo sapiens_hsa003600.37268141
118Viral myocarditis_Homo sapiens_hsa054160.36500535
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.35993734
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34864636
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.33682071
122Fructose and mannose metabolism_Homo sapiens_hsa000510.32599063
123Insulin signaling pathway_Homo sapiens_hsa049100.31956717
124Hippo signaling pathway_Homo sapiens_hsa043900.29907577
125Collecting duct acid secretion_Homo sapiens_hsa049660.24382708
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23832593
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23771669
128Tyrosine metabolism_Homo sapiens_hsa003500.21988452
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20824694
130Circadian rhythm_Homo sapiens_hsa047100.13203402
131Sphingolipid metabolism_Homo sapiens_hsa006000.13077427
132Regulation of autophagy_Homo sapiens_hsa041400.11655159
133Vitamin digestion and absorption_Homo sapiens_hsa049770.09561320
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.09491560
135Fatty acid biosynthesis_Homo sapiens_hsa000610.09358045
136Vibrio cholerae infection_Homo sapiens_hsa051100.08699924
137Ether lipid metabolism_Homo sapiens_hsa005650.06788806

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