PIGX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.95936451
2DNA deamination (GO:0045006)5.57803864
3ribosomal small subunit assembly (GO:0000028)4.97649732
4deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.23019551
5proteasome assembly (GO:0043248)4.15603153
6ATP synthesis coupled proton transport (GO:0015986)4.13746078
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.13746078
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.13556918
9cell proliferation in forebrain (GO:0021846)4.06685178
10telomere maintenance via semi-conservative replication (GO:0032201)3.91735533
11gamma-aminobutyric acid transport (GO:0015812)3.89571896
12maturation of SSU-rRNA (GO:0030490)3.84319588
13ribosomal large subunit biogenesis (GO:0042273)3.81002958
14protein complex biogenesis (GO:0070271)3.73173173
15ribosomal small subunit biogenesis (GO:0042274)3.69816173
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.67850588
17NADH dehydrogenase complex assembly (GO:0010257)3.67850588
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.67850588
19cellular response to ATP (GO:0071318)3.67644946
20viral transcription (GO:0019083)3.66766385
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63221171
22telomere maintenance via recombination (GO:0000722)3.58080520
23translational termination (GO:0006415)3.54850553
24water-soluble vitamin biosynthetic process (GO:0042364)3.51620673
25transmission of nerve impulse (GO:0019226)3.45649575
26DNA strand elongation involved in DNA replication (GO:0006271)3.43139842
27serotonin metabolic process (GO:0042428)3.38184235
28negative regulation of appetite (GO:0032099)3.37625264
29negative regulation of response to food (GO:0032096)3.37625264
30protein polyglutamylation (GO:0018095)3.37380917
31mitochondrial respiratory chain complex assembly (GO:0033108)3.33170014
32DNA strand elongation (GO:0022616)3.32241026
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29673268
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.27124008
35termination of RNA polymerase III transcription (GO:0006386)3.24733325
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.24733325
37substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.24550689
38substrate-independent telencephalic tangential migration (GO:0021826)3.24550689
39CENP-A containing nucleosome assembly (GO:0034080)3.24377389
40mitotic recombination (GO:0006312)3.23869823
41negative regulation of mast cell activation (GO:0033004)3.21943777
42ribonucleoprotein complex biogenesis (GO:0022613)3.19363763
43cotranslational protein targeting to membrane (GO:0006613)3.18890306
44rRNA modification (GO:0000154)3.17678144
45electron transport chain (GO:0022900)3.17297078
46telomere maintenance via telomere lengthening (GO:0010833)3.17240633
47sulfation (GO:0051923)3.16315052
48protein targeting to ER (GO:0045047)3.14028368
49DNA replication initiation (GO:0006270)3.13575483
50negative regulation of transcription regulatory region DNA binding (GO:2000678)3.11803480
51respiratory electron transport chain (GO:0022904)3.10323233
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08941269
53primary amino compound metabolic process (GO:1901160)3.08765572
54negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08459583
55translational elongation (GO:0006414)3.07786435
56purine nucleobase biosynthetic process (GO:0009113)3.04558843
57chromatin remodeling at centromere (GO:0031055)3.03802371
58platelet dense granule organization (GO:0060155)3.02595171
59protein localization to endoplasmic reticulum (GO:0070972)3.01533754
60protein-cofactor linkage (GO:0018065)2.99336269
61kinetochore assembly (GO:0051382)2.99233531
62GTP biosynthetic process (GO:0006183)2.97679418
63regulation of nuclear cell cycle DNA replication (GO:0033262)2.97408384
64response to interferon-beta (GO:0035456)2.97295765
65maturation of 5.8S rRNA (GO:0000460)2.97167470
66rRNA processing (GO:0006364)2.94332924
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94145600
68establishment of protein localization to endoplasmic reticulum (GO:0072599)2.93841623
69nucleobase biosynthetic process (GO:0046112)2.92327908
70epithelial cilium movement (GO:0003351)2.91846105
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91073747
72kynurenine metabolic process (GO:0070189)2.89582899
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88715411
74pseudouridine synthesis (GO:0001522)2.88608925
75lymphoid progenitor cell differentiation (GO:0002320)2.87167700
76epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86396637
77respiratory chain complex IV assembly (GO:0008535)2.86316372
78rRNA metabolic process (GO:0016072)2.84964151
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84917046
80postsynaptic membrane organization (GO:0001941)2.84651762
81positive regulation of meiosis (GO:0045836)2.83806407
82dendritic spine morphogenesis (GO:0060997)2.83340277
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.82327141
84kinetochore organization (GO:0051383)2.81834321
85translational initiation (GO:0006413)2.80603262
86viral life cycle (GO:0019058)2.80466366
87ribosome biogenesis (GO:0042254)2.78911765
88DNA replication-independent nucleosome organization (GO:0034724)2.78557923
89DNA replication-independent nucleosome assembly (GO:0006336)2.78557923
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.78250242
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.78250242
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.78250242
93regulation of cell proliferation involved in kidney development (GO:1901722)2.77734998
94rRNA methylation (GO:0031167)2.77665382
95viral mRNA export from host cell nucleus (GO:0046784)2.77481228
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77397549
97nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.76774784
98DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.75590925
99tRNA methylation (GO:0030488)2.74748962
100deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.74394186
101maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74122754
1027-methylguanosine mRNA capping (GO:0006370)2.73797761
103nucleotide-excision repair, DNA gap filling (GO:0006297)2.73387393
104intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.73188043
105signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.73188043
106pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.72389903
107regulation of action potential (GO:0098900)2.72052949
108translation (GO:0006412)2.72039800
109RNA capping (GO:0036260)2.71323280
1107-methylguanosine RNA capping (GO:0009452)2.71323280
111spliceosomal snRNP assembly (GO:0000387)2.71077718
112negative regulation of ligase activity (GO:0051352)2.70858752
113negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.70858752
114cellular component biogenesis (GO:0044085)2.70817802
115transcription-coupled nucleotide-excision repair (GO:0006283)2.70574431
116pyrimidine nucleobase catabolic process (GO:0006208)2.69791876
117regulation of glomerulus development (GO:0090192)2.68806035
118nonmotile primary cilium assembly (GO:0035058)2.68690988
119cellular protein complex disassembly (GO:0043624)2.68092861
120antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.68076555
121protein neddylation (GO:0045116)2.66543747
122signal transduction involved in DNA integrity checkpoint (GO:0072401)2.63744740
123signal transduction involved in DNA damage checkpoint (GO:0072422)2.63744740
124purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.63484024
125purine nucleoside triphosphate biosynthetic process (GO:0009145)2.62397227
126chaperone-mediated protein transport (GO:0072321)2.60818858
127signal transduction involved in cell cycle checkpoint (GO:0072395)2.60609263
128telomere maintenance (GO:0000723)2.60039644
129indolalkylamine metabolic process (GO:0006586)2.59688621
130parturition (GO:0007567)2.58879411
131termination of RNA polymerase I transcription (GO:0006363)2.58263158
132positive regulation of meiotic cell cycle (GO:0051446)2.57947317
133telomere organization (GO:0032200)2.57797785
134retinal ganglion cell axon guidance (GO:0031290)2.57426443
135hydrogen ion transmembrane transport (GO:1902600)2.56820879
136regulation of cellular amino acid metabolic process (GO:0006521)2.55761822
137antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.54706966
138indole-containing compound metabolic process (GO:0042430)2.54623365
139ubiquinone biosynthetic process (GO:0006744)2.53193019
140presynaptic membrane organization (GO:0097090)2.53188011
141regulation of neurotransmitter uptake (GO:0051580)2.53132473
142neural tube formation (GO:0001841)2.52736961
143ATP biosynthetic process (GO:0006754)2.52685478
144protein localization to synapse (GO:0035418)2.52570063
145DNA synthesis involved in DNA repair (GO:0000731)2.52373711
146replication fork processing (GO:0031297)2.51603775
147regulation of DNA endoreduplication (GO:0032875)2.51533225
148indole-containing compound catabolic process (GO:0042436)2.51523198
149indolalkylamine catabolic process (GO:0046218)2.51523198
150tryptophan catabolic process (GO:0006569)2.51523198
151sex differentiation (GO:0007548)2.51517474
152ribosome assembly (GO:0042255)2.51457792
153pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.50121745
154transcription elongation from RNA polymerase I promoter (GO:0006362)2.49892282
155startle response (GO:0001964)2.49539968
156DNA replication checkpoint (GO:0000076)2.49359593
157formation of translation preinitiation complex (GO:0001731)2.49106121
158DNA catabolic process, exonucleolytic (GO:0000738)2.48795660
159DNA-dependent DNA replication (GO:0006261)2.48522978
160negative regulation of synaptic transmission, GABAergic (GO:0032229)2.47466524
161regulation of double-strand break repair via homologous recombination (GO:0010569)2.46956812
162proton transport (GO:0015992)2.46230509
163negative regulation of telomere maintenance (GO:0032205)2.45873918
164RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.45725415
165tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.45725415
166anterograde synaptic vesicle transport (GO:0048490)2.45176153
167establishment of protein localization to mitochondrial membrane (GO:0090151)2.44934244
168cellular response to interferon-beta (GO:0035458)2.44306925
169purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.41775927
1703-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.41775927
171response to pheromone (GO:0019236)2.41593762
172positive regulation of mitochondrial fission (GO:0090141)2.39466264
173hydrogen transport (GO:0006818)2.39181179
174regulation of collateral sprouting (GO:0048670)2.39131018
175opioid receptor signaling pathway (GO:0038003)2.38331627
176negative regulation of systemic arterial blood pressure (GO:0003085)2.37659650
177axoneme assembly (GO:0035082)2.36963533
178protein K6-linked ubiquitination (GO:0085020)2.36364272
179estrogen biosynthetic process (GO:0006703)2.35193094
180anterograde axon cargo transport (GO:0008089)2.35182517
181cellular anion homeostasis (GO:0030002)2.33529657
182synaptic transmission, cholinergic (GO:0007271)2.32901601
183pyrimidine nucleotide catabolic process (GO:0006244)2.31724875
184central nervous system myelination (GO:0022010)2.31701537
185axon ensheathment in central nervous system (GO:0032291)2.31701537
186* preassembly of GPI anchor in ER membrane (GO:0016254)2.31041940
187cornea development in camera-type eye (GO:0061303)2.29806826
188synaptic transmission, glutamatergic (GO:0035249)2.28663127
189response to xenobiotic stimulus (GO:0009410)2.28037659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.26235660
2E2F7_22180533_ChIP-Seq_HELA_Human6.11622112
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.78589204
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.49966251
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.39156814
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.35099757
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.25808347
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.23679445
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.21022782
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.98886156
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98502473
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84387417
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79599560
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.75183186
15ZNF274_21170338_ChIP-Seq_K562_Hela2.70478007
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.69502688
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68681217
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.65288227
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65112363
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57529922
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.55648008
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.51967894
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50094678
24VDR_23849224_ChIP-Seq_CD4+_Human2.49497522
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45616763
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.42891698
27IGF1R_20145208_ChIP-Seq_DFB_Human2.42492973
28MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40891954
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40843542
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.30911896
31GBX2_23144817_ChIP-Seq_PC3_Human2.29202171
32VDR_22108803_ChIP-Seq_LS180_Human2.28171715
33MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26389068
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24770554
35CBX2_27304074_Chip-Seq_ESCs_Mouse2.22859066
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19722833
37REST_21632747_ChIP-Seq_MESCs_Mouse2.15948141
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.14664658
39FOXP3_21729870_ChIP-Seq_TREG_Human2.14251971
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13172791
41CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12504745
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.11368667
43EZH2_27304074_Chip-Seq_ESCs_Mouse2.07761747
44JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06587158
45* SRF_21415370_ChIP-Seq_HL-1_Mouse2.06433081
46HOXB4_20404135_ChIP-ChIP_EML_Mouse2.04134665
47FOXM1_23109430_ChIP-Seq_U2OS_Human2.02414572
48XRN2_22483619_ChIP-Seq_HELA_Human1.99340199
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97600174
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96759103
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.96724774
52EWS_26573619_Chip-Seq_HEK293_Human1.92396994
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90917053
54ELK1_19687146_ChIP-ChIP_HELA_Human1.90836650
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.90723371
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90599874
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.89733525
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.89425471
59* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86377978
60* DCP1A_22483619_ChIP-Seq_HELA_Human1.86293696
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.84037470
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.83964476
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80853125
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79301917
65SPI1_23547873_ChIP-Seq_NB4_Human1.78581833
66FUS_26573619_Chip-Seq_HEK293_Human1.78327519
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75549295
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73595675
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.71666546
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69627853
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68625068
72GABP_19822575_ChIP-Seq_HepG2_Human1.68388624
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67889608
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.67782147
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.67405466
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66229926
77TTF2_22483619_ChIP-Seq_HELA_Human1.65756213
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.64681569
79SCL_19346495_ChIP-Seq_HPC-7_Human1.64157790
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61351049
81RNF2_27304074_Chip-Seq_NSC_Mouse1.61088696
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57155193
83THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54683953
84TP53_22573176_ChIP-Seq_HFKS_Human1.54322797
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53578144
86ER_23166858_ChIP-Seq_MCF-7_Human1.50391685
87* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49202801
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.45792079
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45491726
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.44617142
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43980744
92SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42395493
93CIITA_25753668_ChIP-Seq_RAJI_Human1.37460949
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36933781
95E2F1_21310950_ChIP-Seq_MCF-7_Human1.34947905
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34750527
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32249602
98NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31992204
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31679010
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31054194
101P300_19829295_ChIP-Seq_ESCs_Human1.30837606
102SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30803012
103TAF15_26573619_Chip-Seq_HEK293_Human1.30688652
104CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29305100
105ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29241834
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28639634
107NCOR_22424771_ChIP-Seq_293T_Human1.24963837
108MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24839529
109MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24116710
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23856060
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.23856060
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23167564
113AR_21909140_ChIP-Seq_LNCAP_Human1.22951724
114MYC_18940864_ChIP-ChIP_HL60_Human1.22810768
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22304874
116SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21595994
117ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17309813
118SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15988983
119MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14067199
120ELK1_22589737_ChIP-Seq_MCF10A_Human1.12348938
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12205159
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11417368
123SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11104290
124ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10280732
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10068842
126LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06976704
127POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05769845
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05161438
129IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04716541
130RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04554865
131EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04554865
132IRF1_19129219_ChIP-ChIP_H3396_Human1.03631228
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02789905
134* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02582389
135EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02012620
136MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02009545
137TP53_20018659_ChIP-ChIP_R1E_Mouse1.00834063
138RING1B_27294783_Chip-Seq_ESCs_Mouse1.00323664
139MYB_26560356_Chip-Seq_TH2_Human0.99256010
140TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98729399
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98528773
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98460892
143CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97881050
144GATA3_21878914_ChIP-Seq_MCF-7_Human0.97553912
145JUN_21703547_ChIP-Seq_K562_Human0.97404570
146STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97320225
147TAF2_19829295_ChIP-Seq_ESCs_Human0.97123287
148ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96814623
149PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95939263
150HOXB7_26014856_ChIP-Seq_BT474_Human0.95873580
151ERA_21632823_ChIP-Seq_H3396_Human0.95737141
152PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95237892
153AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94505178
154UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93650180
155FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93545101
156SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93420537
157LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92494398
158ERG_20517297_ChIP-Seq_VCAP_Human0.92178781
159RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91979297
160BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91774628
161BCAT_22108803_ChIP-Seq_LS180_Human0.91117680
162CBP_20019798_ChIP-Seq_JUKART_Human0.90391750
163IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90391750
164LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89566738
165SMAD4_21799915_ChIP-Seq_A2780_Human0.88805708
166FLI1_21867929_ChIP-Seq_TH2_Mouse0.88776276
167AR_20517297_ChIP-Seq_VCAP_Human0.88446531
168RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88177098
169GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88049454
170AR_25329375_ChIP-Seq_VCAP_Human0.87679726
171TCF4_23295773_ChIP-Seq_U87_Human0.86730131
172FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85193750
173FLI1_27457419_Chip-Seq_LIVER_Mouse0.84638280
174E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82983484
175KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81838775
176MYB_26560356_Chip-Seq_TH1_Human0.80523536
177STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.80150264
178KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79898687
179VDR_21846776_ChIP-Seq_THP-1_Human0.79202143
180RUNX1_22412390_ChIP-Seq_EML_Mouse0.78294504
181TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.74696645
182GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74165793

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.56897591
2MP0003693_abnormal_embryo_hatching3.46827521
3MP0008058_abnormal_DNA_repair3.05363082
4MP0010094_abnormal_chromosome_stability3.00797684
5MP0001835_abnormal_antigen_presentation2.86017709
6MP0005671_abnormal_response_to2.75487150
7MP0008007_abnormal_cellular_replicative2.63385946
8MP0003880_abnormal_central_pattern2.53030058
9MP0003787_abnormal_imprinting2.48433389
10MP0009785_altered_susceptibility_to2.48327189
11MP0003111_abnormal_nucleus_morphology2.48212587
12MP0003646_muscle_fatigue2.37056629
13MP0000490_abnormal_crypts_of2.36313541
14MP0001968_abnormal_touch/_nociception2.31448248
15MP0003077_abnormal_cell_cycle2.28900562
16MP0003763_abnormal_thymus_physiology2.26854531
17MP0004957_abnormal_blastocyst_morpholog2.17669760
18MP0000566_synostosis2.17156187
19MP0000569_abnormal_digit_pigmentation2.15170162
20MP0001919_abnormal_reproductive_system2.12163704
21MP0002837_dystrophic_cardiac_calcinosis2.10857265
22MP0009046_muscle_twitch2.09451827
23MP0005423_abnormal_somatic_nervous2.06378461
24MP0004142_abnormal_muscle_tone2.05068287
25MP0003786_premature_aging2.04749883
26MP0009333_abnormal_splenocyte_physiolog2.02581488
27MP0004808_abnormal_hematopoietic_stem2.02112201
28MP0004885_abnormal_endolymph2.01975160
29MP0003011_delayed_dark_adaptation2.01440225
30MP0004145_abnormal_muscle_electrophysio2.01293075
31MP0008057_abnormal_DNA_replication2.00598909
32MP0009745_abnormal_behavioral_response1.97769635
33MP0005389_reproductive_system_phenotype1.96591088
34MP0002272_abnormal_nervous_system1.95381589
35MP0002148_abnormal_hypersensitivity_rea1.89696140
36MP0000685_abnormal_immune_system1.89501934
37MP0005025_abnormal_response_to1.88384049
38MP0001188_hyperpigmentation1.81804722
39MP0005174_abnormal_tail_pigmentation1.81130217
40MP0002160_abnormal_reproductive_system1.80375977
41MP0005646_abnormal_pituitary_gland1.78620990
42MP0002452_abnormal_antigen_presenting1.77941917
43MP0009379_abnormal_foot_pigmentation1.77810334
44MP0005075_abnormal_melanosome_morpholog1.76807453
45MP0002398_abnormal_bone_marrow1.76357486
46MP0003724_increased_susceptibility_to1.76139077
47MP0002132_abnormal_respiratory_system1.75681906
48MP0002420_abnormal_adaptive_immunity1.74858834
49MP0001819_abnormal_immune_cell1.74772343
50MP0001800_abnormal_humoral_immune1.72297561
51MP0002723_abnormal_immune_serum1.72263227
52MP0008872_abnormal_physiological_respon1.70140867
53MP0002064_seizures1.69819282
54MP0006292_abnormal_olfactory_placode1.68578877
55MP0005000_abnormal_immune_tolerance1.67103242
56MP0002736_abnormal_nociception_after1.65476193
57MP0002095_abnormal_skin_pigmentation1.64392011
58MP0001853_heart_inflammation1.63877491
59MP0000631_abnormal_neuroendocrine_gland1.63634737
60MP0003635_abnormal_synaptic_transmissio1.63080558
61MP0002653_abnormal_ependyma_morphology1.62675203
62MP0005551_abnormal_eye_electrophysiolog1.62418478
63MP0002735_abnormal_chemical_nociception1.61886697
64MP0000015_abnormal_ear_pigmentation1.60507085
65MP0002102_abnormal_ear_morphology1.59743247
66MP0009697_abnormal_copulation1.59379401
67MP0000716_abnormal_immune_system1.59226738
68MP0001986_abnormal_taste_sensitivity1.57712690
69MP0002419_abnormal_innate_immunity1.56599024
70MP0002722_abnormal_immune_system1.55383367
71MP0001873_stomach_inflammation1.55047879
72MP0000689_abnormal_spleen_morphology1.52897358
73MP0002572_abnormal_emotion/affect_behav1.52045583
74MP0000427_abnormal_hair_cycle1.50499695
75MP0004742_abnormal_vestibular_system1.49151947
76MP0006072_abnormal_retinal_apoptosis1.48522213
77MP0002938_white_spotting1.48395936
78MP0002734_abnormal_mechanical_nocicepti1.47635329
79MP0002063_abnormal_learning/memory/cond1.46452487
80MP0010155_abnormal_intestine_physiology1.45589863
81MP0006276_abnormal_autonomic_nervous1.44325846
82MP0002928_abnormal_bile_duct1.44325259
83MP0002429_abnormal_blood_cell1.43908958
84MP0001545_abnormal_hematopoietic_system1.43407690
85MP0005397_hematopoietic_system_phenotyp1.43407690
86MP0001485_abnormal_pinna_reflex1.43347894
87MP0002876_abnormal_thyroid_physiology1.43081617
88MP0002557_abnormal_social/conspecific_i1.39816864
89MP0002733_abnormal_thermal_nociception1.38443910
90MP0005387_immune_system_phenotype1.38364375
91MP0001790_abnormal_immune_system1.38364375
92MP0001486_abnormal_startle_reflex1.37890502
93MP0001970_abnormal_pain_threshold1.36627642
94MP0003436_decreased_susceptibility_to1.35284440
95MP0003718_maternal_effect1.34082128
96MP0001905_abnormal_dopamine_level1.31181767
97MP0003186_abnormal_redox_activity1.31041934
98MP0004134_abnormal_chest_morphology1.30084079
99MP0000703_abnormal_thymus_morphology1.28101608
100MP0002067_abnormal_sensory_capabilities1.26112091
101MP0003195_calcinosis1.24215386
102MP0002405_respiratory_system_inflammati1.23340627
103MP0005253_abnormal_eye_physiology1.23324601
104MP0005464_abnormal_platelet_physiology1.23176681
105MP0005645_abnormal_hypothalamus_physiol1.22412629
106MP0002006_tumorigenesis1.21196838
107MP0000858_altered_metastatic_potential1.19811581
108MP0003315_abnormal_perineum_morphology1.19778369
109MP0000465_gastrointestinal_hemorrhage1.19604859
110MP0000778_abnormal_nervous_system1.18482934
111MP0002166_altered_tumor_susceptibility1.17283431
112MP0003941_abnormal_skin_development1.16316482
113MP0008932_abnormal_embryonic_tissue1.15037673
114MP0004133_heterotaxia1.14730337
115MP0004270_analgesia1.14481312
116MP0003938_abnormal_ear_development1.13868919
117MP0001984_abnormal_olfaction1.13584680
118MP0002184_abnormal_innervation1.13475232
119MP0003121_genomic_imprinting1.12575702
120MP0008789_abnormal_olfactory_epithelium1.12377952
121MP0002163_abnormal_gland_morphology1.11579983
122MP0002019_abnormal_tumor_incidence1.08838147
123MP0000955_abnormal_spinal_cord1.08230094
124MP0000372_irregular_coat_pigmentation1.07101235
125MP0003866_abnormal_defecation1.06281418
126MP0000313_abnormal_cell_death1.05858380
127MP0001845_abnormal_inflammatory_respons1.04570444
128MP0004381_abnormal_hair_follicle1.03409371
129MP0001440_abnormal_grooming_behavior1.02179023
130MP0008877_abnormal_DNA_methylation0.99912078
131MP0002752_abnormal_somatic_nervous0.99787429
132MP0008995_early_reproductive_senescence0.98828004
133MP0003136_yellow_coat_color0.98176932
134MP0003879_abnormal_hair_cell0.98000444
135MP0008260_abnormal_autophagy0.95020090
136MP0003567_abnormal_fetal_cardiomyocyte0.94543455
137MP0005386_behavior/neurological_phenoty0.92843740
138MP0004924_abnormal_behavior0.92843740
139MP0005195_abnormal_posterior_eye0.92745178
140MP0004859_abnormal_synaptic_plasticity0.91829163
141MP0002693_abnormal_pancreas_physiology0.91676497
142MP0001119_abnormal_female_reproductive0.91313658
143MP0002277_abnormal_respiratory_mucosa0.90984273
144MP0002909_abnormal_adrenal_gland0.90711071
145MP0001502_abnormal_circadian_rhythm0.90250986
146MP0000026_abnormal_inner_ear0.88412362
147MP0005409_darkened_coat_color0.87431420
148MP0005451_abnormal_body_composition0.86703755
149MP0004147_increased_porphyrin_level0.86598194
150MP0002882_abnormal_neuron_morphology0.85347171
151MP0005084_abnormal_gallbladder_morpholo0.84611841
152MP0001186_pigmentation_phenotype0.84427436
153MP0001501_abnormal_sleep_pattern0.84326896
154MP0000049_abnormal_middle_ear0.84003319
155MP0004130_abnormal_muscle_cell0.83846515
156MP0006036_abnormal_mitochondrial_physio0.82446015
157MP0002210_abnormal_sex_determination0.82168285
158MP0001727_abnormal_embryo_implantation0.81946139
159MP0008469_abnormal_protein_level0.81763353
160MP0003122_maternal_imprinting0.80840124
161MP0002075_abnormal_coat/hair_pigmentati0.80692920
162MP0001346_abnormal_lacrimal_gland0.80470348
163MP0000350_abnormal_cell_proliferation0.79538010
164MP0002822_catalepsy0.77802273
165MP0009250_abnormal_appendicular_skeleto0.75746671
166MP0002933_joint_inflammation0.75443754
167MP0006035_abnormal_mitochondrial_morpho0.74657442
168MP0003943_abnormal_hepatobiliary_system0.74516180
169MP0001765_abnormal_ion_homeostasis0.74034600
170MP0001764_abnormal_homeostasis0.73013399
171MP0005394_taste/olfaction_phenotype0.72167965
172MP0005499_abnormal_olfactory_system0.72167965
173MP0002152_abnormal_brain_morphology0.70959277
174MP0005310_abnormal_salivary_gland0.69993655
175MP0003638_abnormal_response/metabolism_0.69560355
176MP0005379_endocrine/exocrine_gland_phen0.68322901
177MP0002638_abnormal_pupillary_reflex0.67259587
178MP0000371_diluted_coat_color0.67007349
179MP0000613_abnormal_salivary_gland0.66156161
180MP0001145_abnormal_male_reproductive0.65564353
181MP0006082_CNS_inflammation0.65228964
182MP0003448_altered_tumor_morphology0.63711797
183MP0001529_abnormal_vocalization0.63638810

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.40435810
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.16757721
3Chromsome breakage (HP:0040012)3.93105704
4Pancreatic fibrosis (HP:0100732)3.83728451
5Pancreatic cysts (HP:0001737)3.83068996
6Molar tooth sign on MRI (HP:0002419)3.68946273
7Abnormality of midbrain morphology (HP:0002418)3.68946273
8IgM deficiency (HP:0002850)3.58315031
9True hermaphroditism (HP:0010459)3.43583947
10Aplastic anemia (HP:0001915)3.38899153
11Elevated erythrocyte sedimentation rate (HP:0003565)3.38039295
12Abnormality of the preputium (HP:0100587)3.35396271
13Abnormal number of erythroid precursors (HP:0012131)3.33834337
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.33080676
15Concave nail (HP:0001598)3.31093127
16Abnormality of cells of the erythroid lineage (HP:0012130)3.30758733
17Pendular nystagmus (HP:0012043)3.24254524
18Acute necrotizing encephalopathy (HP:0006965)3.20348173
19Nephronophthisis (HP:0000090)3.19612647
20Type I transferrin isoform profile (HP:0003642)3.18865129
21Myositis (HP:0100614)3.16076689
22Abnormal mitochondria in muscle tissue (HP:0008316)3.00618236
23Abnormal rod and cone electroretinograms (HP:0008323)2.85507213
24Thrombocytosis (HP:0001894)2.84851013
25Reduced antithrombin III activity (HP:0001976)2.84180667
26Acute encephalopathy (HP:0006846)2.82574464
27Birth length less than 3rd percentile (HP:0003561)2.82164057
28Agitation (HP:0000713)2.81767871
29Mitochondrial inheritance (HP:0001427)2.80626688
30Meckel diverticulum (HP:0002245)2.79960664
31Congenital stationary night blindness (HP:0007642)2.79414689
32Progressive cerebellar ataxia (HP:0002073)2.78485233
33Progressive macrocephaly (HP:0004481)2.76009402
34Panhypogammaglobulinemia (HP:0003139)2.75849897
35Type II lissencephaly (HP:0007260)2.69557994
36Asplenia (HP:0001746)2.69535806
37Recurrent abscess formation (HP:0002722)2.67860093
383-Methylglutaconic aciduria (HP:0003535)2.67052143
39Pallor (HP:0000980)2.65341283
40Abnormality of the ileum (HP:0001549)2.64819647
41Abnormality of chromosome stability (HP:0003220)2.60487065
42Increased CSF lactate (HP:0002490)2.60173226
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.58812788
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.58220953
45Aplasia/Hypoplasia of the spleen (HP:0010451)2.57720291
46Abnormality of the renal medulla (HP:0100957)2.55047749
47Type 2 muscle fiber atrophy (HP:0003554)2.52791516
48Medial flaring of the eyebrow (HP:0010747)2.52580444
4911 pairs of ribs (HP:0000878)2.52248404
50Petechiae (HP:0000967)2.52004596
51Focal motor seizures (HP:0011153)2.51027106
52Cystic liver disease (HP:0006706)2.49631876
53Abnormality of DNA repair (HP:0003254)2.46723518
54IgG deficiency (HP:0004315)2.46650578
55Abolished electroretinogram (ERG) (HP:0000550)2.46303029
56Myelodysplasia (HP:0002863)2.45408936
57Abnormal protein glycosylation (HP:0012346)2.43417093
58Abnormal glycosylation (HP:0012345)2.43417093
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.43417093
60Abnormal protein N-linked glycosylation (HP:0012347)2.43417093
61Tubular atrophy (HP:0000092)2.43116364
62Microvesicular hepatic steatosis (HP:0001414)2.41203475
63Abnormality of B cell number (HP:0010975)2.39702609
64B lymphocytopenia (HP:0010976)2.39702609
65Sclerocornea (HP:0000647)2.39440480
66Pancytopenia (HP:0001876)2.35915031
67Macrocytic anemia (HP:0001972)2.35745520
68Genetic anticipation (HP:0003743)2.33689492
69Clubbing of toes (HP:0100760)2.32562718
70Abnormality of the prostate (HP:0008775)2.31700024
71Recurrent bacterial skin infections (HP:0005406)2.31573307
72Bone marrow hypocellularity (HP:0005528)2.31496435
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.31413005
74Abnormality of T cell physiology (HP:0011840)2.31177584
75Visual hallucinations (HP:0002367)2.30344450
76Increased hepatocellular lipid droplets (HP:0006565)2.28887751
77Gait imbalance (HP:0002141)2.28397434
78Oral leukoplakia (HP:0002745)2.28083873
79Muscle fiber atrophy (HP:0100295)2.25896132
80Breast hypoplasia (HP:0003187)2.24684766
81Severe combined immunodeficiency (HP:0004430)2.24535051
82Optic neuritis (HP:0100653)2.24463184
83Retrobulbar optic neuritis (HP:0100654)2.24463184
84Lissencephaly (HP:0001339)2.23807280
85Chronic otitis media (HP:0000389)2.20524601
86Furrowed tongue (HP:0000221)2.20022958
87Encephalitis (HP:0002383)2.19649423
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18358800
89Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18358800
90Poikiloderma (HP:0001029)2.16974895
91Exertional dyspnea (HP:0002875)2.16602056
92Aplasia/Hypoplasia of the tibia (HP:0005772)2.15512063
93Triphalangeal thumb (HP:0001199)2.14741329
94Lymphoma (HP:0002665)2.12569968
95Hepatocellular necrosis (HP:0001404)2.12181254
96Oligodactyly (hands) (HP:0001180)2.11656071
97Abnormality of the renal cortex (HP:0011035)2.10917800
98Small intestinal stenosis (HP:0012848)2.09175743
99Duodenal stenosis (HP:0100867)2.09175743
100Rough bone trabeculation (HP:0100670)2.09128103
101Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07721574
102Congenital primary aphakia (HP:0007707)2.07552886
103Premature graying of hair (HP:0002216)2.05844891
104Anencephaly (HP:0002323)2.05684247
105Fibular aplasia (HP:0002990)2.05567045
106Short tibia (HP:0005736)2.04671085
107Microretrognathia (HP:0000308)2.04280546
108Abnormality of the renal collecting system (HP:0004742)2.03981677
109Duplicated collecting system (HP:0000081)2.02739695
110Pachygyria (HP:0001302)2.02619028
111Congenital, generalized hypertrichosis (HP:0004540)2.02083259
112Abnormality of T cells (HP:0002843)2.01370495
113Nephrogenic diabetes insipidus (HP:0009806)2.01343654
114Recurrent fungal infections (HP:0002841)2.00482436
115Abnormal delayed hypersensitivity skin test (HP:0002963)2.00397394
116Abnormal drinking behavior (HP:0030082)1.98250195
117Polydipsia (HP:0001959)1.98250195
118Hypoplasia of the thymus (HP:0000778)1.97978724
119Methylmalonic acidemia (HP:0002912)1.97153443
120Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96315667
121Abnormality of alanine metabolism (HP:0010916)1.96315667
122Hyperalaninemia (HP:0003348)1.96315667
123Granulocytopenia (HP:0001913)1.96083545
124Pustule (HP:0200039)1.95648228
125Degeneration of anterior horn cells (HP:0002398)1.94004979
126Abnormality of the anterior horn cell (HP:0006802)1.94004979
127Myokymia (HP:0002411)1.93906714
128Renal Fanconi syndrome (HP:0001994)1.93699260
129Congenital sensorineural hearing impairment (HP:0008527)1.92230502
130Hemiparesis (HP:0001269)1.91464182
131Abnormal lung lobation (HP:0002101)1.90853948
132Orchitis (HP:0100796)1.90196339
133Abnormal respiratory epithelium morphology (HP:0012253)1.90007837
134Abnormal respiratory motile cilium morphology (HP:0005938)1.90007837
135Optic disc pallor (HP:0000543)1.89910312
136Abnormality of the axillary hair (HP:0100134)1.89825578
137Abnormality of secondary sexual hair (HP:0009888)1.89825578
138Abnormal spermatogenesis (HP:0008669)1.89525884
139Aplasia/hypoplasia of the uterus (HP:0008684)1.89208375
140Mediastinal lymphadenopathy (HP:0100721)1.88107795
141Meningitis (HP:0001287)1.88097358
142Severe visual impairment (HP:0001141)1.86884324
143Poor head control (HP:0002421)1.86016543
144Thyroiditis (HP:0100646)1.85795738
145Hepatic necrosis (HP:0002605)1.85678358
146Absent thumb (HP:0009777)1.85457572
147Increased serum lactate (HP:0002151)1.85288982
148Congenital hepatic fibrosis (HP:0002612)1.85058772
149Lipid accumulation in hepatocytes (HP:0006561)1.84446070
150Entropion (HP:0000621)1.83149951
151Recurrent viral infections (HP:0004429)1.81845467
152Recurrent cutaneous fungal infections (HP:0011370)1.81809602
153Chronic mucocutaneous candidiasis (HP:0002728)1.81809602
154Aplasia/Hypoplasia of the tongue (HP:0010295)1.81255939
155Chronic hepatic failure (HP:0100626)1.80986469
156Leukopenia (HP:0001882)1.80315936
157Attenuation of retinal blood vessels (HP:0007843)1.80000117
158Decreased central vision (HP:0007663)1.78664295
159Keratoconus (HP:0000563)1.78477474
160Increased corneal curvature (HP:0100692)1.78477474
161Male pseudohermaphroditism (HP:0000037)1.78303947
162Chronic obstructive pulmonary disease (HP:0006510)1.77369396
163Obstructive lung disease (HP:0006536)1.77369396
164Aplasia/Hypoplasia of the fibula (HP:0006492)1.76217893
165Hyperventilation (HP:0002883)1.75836019
166Retinitis pigmentosa (HP:0000510)1.75617212
167Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75143899
168Oligodactyly (HP:0012165)1.73737616
169Confusion (HP:0001289)1.73372577
170Postaxial foot polydactyly (HP:0001830)1.73302627
171Hyperthyroidism (HP:0000836)1.72081475
172Vaginal atresia (HP:0000148)1.71578953
173Hyperglycinemia (HP:0002154)1.71057027
174Limb dystonia (HP:0002451)1.69717958
175Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69349237
176Lactic acidosis (HP:0003128)1.68353539
177Symphalangism affecting the phalanges of the hand (HP:0009773)1.67165030
178Genital tract atresia (HP:0001827)1.67075281
179Dynein arm defect of respiratory motile cilia (HP:0012255)1.67038282
180Absent/shortened dynein arms (HP:0200106)1.67038282
181Hypoplastic pelvis (HP:0008839)1.66718800
182Methylmalonic aciduria (HP:0012120)1.65302489
183Bony spicule pigmentary retinopathy (HP:0007737)1.64155712
184Diplopia (HP:0000651)1.64153007
185Abnormality of binocular vision (HP:0011514)1.64153007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.80922546
2STK163.67907293
3PINK13.18653183
4FRK3.13995232
5NME22.92149011
6WEE12.60300271
7TXK2.48129736
8TNIK2.42355907
9TAOK32.37026893
10SRPK12.33029228
11ZAK2.21544097
12ACVR1B2.13713816
13TEC2.13089335
14IRAK42.12567976
15VRK12.06970693
16EIF2AK12.05550371
17BCKDK2.05252804
18MAPK131.99683115
19EIF2AK31.95135728
20PLK41.94558213
21KIT1.92276831
22BLK1.89091791
23MKNK11.88616689
24EIF2AK21.87972982
25PIM21.87536262
26MUSK1.77518731
27MAP4K11.76226366
28MAP3K111.74314287
29GRK61.73231240
30MINK11.72502887
31MAP3K41.72325985
32KDR1.70039772
33PNCK1.66780986
34CAMKK21.59792394
35DYRK31.58167829
36MKNK21.57158265
37PAK31.54854944
38SIK31.51987086
39DAPK21.46825606
40MAP2K71.46647744
41IRAK31.43010996
42CAMKK11.41970694
43PRKCG1.41736305
44MAP2K41.37757032
45BTK1.35049756
46MAP3K91.34497439
47IKBKE1.33912778
48MARK11.33501004
49GRK71.32357364
50CDK81.31225563
51NEK21.29772593
52LIMK11.28462054
53WNK31.26120490
54ATR1.26002494
55NLK1.25702526
56ZAP701.24237634
57IKBKB1.23990289
58JAK31.23492097
59TGFBR11.22057629
60BRSK21.20815682
61ADRBK11.20767270
62EPHA41.20150766
63RPS6KA41.18873856
64FLT31.16770860
65TBK11.15996411
66CSNK1G21.14519339
67YES11.14016862
68PRKCH1.13988482
69WNK41.13863895
70ADRBK21.13590208
71BMPR1B1.13507541
72NTRK21.12069997
73TTK1.10070691
74PLK11.09078733
75INSRR1.07930705
76TYK21.06006302
77MAP3K141.04840575
78TIE11.03459488
79CDC71.02434965
80PIM11.02007269
81AURKB1.01452090
82MAP3K121.01273295
83MAP4K21.00714044
84CDK70.97080704
85STK110.95223703
86GRK50.92751563
87PHKG20.91992316
88PHKG10.91992316
89PRKD20.89974183
90CSNK1A1L0.86662144
91CSF1R0.86618234
92NTRK30.84034455
93LYN0.82652149
94PRKCQ0.82415238
95GRK10.80571290
96CLK10.80546109
97ABL20.80188730
98TSSK60.80179803
99SYK0.79304143
100CSNK1G10.79001390
101MAP2K30.78108007
102CCNB10.76629940
103SIK20.74958432
104RPS6KB20.74312164
105PLK20.73534312
106PRKCZ0.72422791
107STK40.71336400
108LCK0.69332606
109CAMK10.68989803
110ARAF0.68870239
111CHEK20.68831043
112PASK0.67793226
113NUAK10.67371710
114DYRK20.65563241
115CAMK2A0.62203936
116PRKCI0.61719738
117PIK3CA0.61670884
118MAP2K60.60367246
119MYLK0.59618036
120PRKG20.59608872
121TLK10.58587574
122PLK30.57649575
123RIPK40.57610734
124IRAK20.57599348
125PAK60.57372962
126RPS6KA50.57360527
127PRKACA0.57056875
128CSNK2A10.56735874
129CAMK2B0.56532466
130IRAK10.56022706
131PRKCE0.55624035
132OXSR10.52996189
133CHUK0.52629167
134CSNK1A10.52183979
135PAK40.49099212
136EPHA20.48308614
137PRKCD0.46738157
138MAP3K60.46504617
139CDK30.45694024
140CDK40.45674852
141MAP2K20.45218032
142ERBB20.42947893
143PKN10.41610555
144PRKCA0.39619020
145AURKA0.37477461
146TESK20.37070913
147MAP3K130.36677035
148STK240.36322347
149UHMK10.35951515
150BRSK10.35900144
151MAPKAPK30.35771257
152CSNK2A20.35178686
153FES0.35071301
154STK390.34921942
155RPS6KA60.34835716
156SGK4940.34087181
157SGK2230.34087181
158MAPK40.32296573
159ATM0.32153658
160ITK0.31569280
161CASK0.30733568
162TGFBR20.29863545
163CSNK1G30.27560623
164MARK30.27439996
165MATK0.26802170
166BRAF0.26162218
167STK100.25926474

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.91870241
2Ribosome_Homo sapiens_hsa030103.87450708
3Proteasome_Homo sapiens_hsa030503.33373706
4RNA polymerase_Homo sapiens_hsa030203.23562756
5Mismatch repair_Homo sapiens_hsa034303.16447282
6Homologous recombination_Homo sapiens_hsa034402.96656947
7Base excision repair_Homo sapiens_hsa034102.75837637
8Nicotine addiction_Homo sapiens_hsa050332.75428338
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.69165532
10Pyrimidine metabolism_Homo sapiens_hsa002402.64139621
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63056759
12Cardiac muscle contraction_Homo sapiens_hsa042602.49353997
13Spliceosome_Homo sapiens_hsa030402.48803919
14Nucleotide excision repair_Homo sapiens_hsa034202.36668325
15Fanconi anemia pathway_Homo sapiens_hsa034602.30492458
16Non-homologous end-joining_Homo sapiens_hsa034502.18536298
17Phototransduction_Homo sapiens_hsa047442.16771999
18Morphine addiction_Homo sapiens_hsa050322.11228926
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.97736113
20Primary immunodeficiency_Homo sapiens_hsa053401.96855995
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87601768
22Basal transcription factors_Homo sapiens_hsa030221.84174295
23GABAergic synapse_Homo sapiens_hsa047271.79155747
24RNA transport_Homo sapiens_hsa030131.72488671
25RNA degradation_Homo sapiens_hsa030181.66500945
26Glutamatergic synapse_Homo sapiens_hsa047241.66238272
27Cell cycle_Homo sapiens_hsa041101.65312062
28Protein export_Homo sapiens_hsa030601.60144874
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58611393
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58152436
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.55647022
32Circadian entrainment_Homo sapiens_hsa047131.51233351
33Nitrogen metabolism_Homo sapiens_hsa009101.48222676
34Purine metabolism_Homo sapiens_hsa002301.46268164
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45346451
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43095443
37Herpes simplex infection_Homo sapiens_hsa051681.38596212
38Allograft rejection_Homo sapiens_hsa053301.38126869
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34168854
40p53 signaling pathway_Homo sapiens_hsa041151.32125723
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.31504709
42Measles_Homo sapiens_hsa051621.31376905
43Collecting duct acid secretion_Homo sapiens_hsa049661.27635022
44Insulin secretion_Homo sapiens_hsa049111.27536324
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.25483316
46Serotonergic synapse_Homo sapiens_hsa047261.20336902
47Dopaminergic synapse_Homo sapiens_hsa047281.19386424
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17008708
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14770226
50Cholinergic synapse_Homo sapiens_hsa047251.11615518
51Olfactory transduction_Homo sapiens_hsa047401.11080499
52Hematopoietic cell lineage_Homo sapiens_hsa046401.10167625
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05302272
54Epstein-Barr virus infection_Homo sapiens_hsa051691.04148577
55Asthma_Homo sapiens_hsa053101.03240873
56Taste transduction_Homo sapiens_hsa047421.02543837
57One carbon pool by folate_Homo sapiens_hsa006701.01533667
58Linoleic acid metabolism_Homo sapiens_hsa005910.99346132
59Folate biosynthesis_Homo sapiens_hsa007900.99029342
60Synaptic vesicle cycle_Homo sapiens_hsa047210.98527293
61Leishmaniasis_Homo sapiens_hsa051400.97816315
62Tryptophan metabolism_Homo sapiens_hsa003800.97235239
63Legionellosis_Homo sapiens_hsa051340.92699349
64Sulfur metabolism_Homo sapiens_hsa009200.91898088
65Autoimmune thyroid disease_Homo sapiens_hsa053200.91105796
66Antigen processing and presentation_Homo sapiens_hsa046120.89354336
67Caffeine metabolism_Homo sapiens_hsa002320.88926694
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88517766
69Peroxisome_Homo sapiens_hsa041460.88011735
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87298458
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86997537
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86338509
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83990351
74Other glycan degradation_Homo sapiens_hsa005110.83265559
75Graft-versus-host disease_Homo sapiens_hsa053320.82230843
76Systemic lupus erythematosus_Homo sapiens_hsa053220.81967198
77Dorso-ventral axis formation_Homo sapiens_hsa043200.81236083
78Ovarian steroidogenesis_Homo sapiens_hsa049130.78910646
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.78193364
80N-Glycan biosynthesis_Homo sapiens_hsa005100.74585204
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.74418056
82Arachidonic acid metabolism_Homo sapiens_hsa005900.73315571
83Butanoate metabolism_Homo sapiens_hsa006500.71918223
84Calcium signaling pathway_Homo sapiens_hsa040200.71864408
85Influenza A_Homo sapiens_hsa051640.71599136
86Amphetamine addiction_Homo sapiens_hsa050310.71278774
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70862189
88Parkinsons disease_Homo sapiens_hsa050120.70257567
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70032406
90Chemical carcinogenesis_Homo sapiens_hsa052040.69125514
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68501021
92* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67800600
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67285584
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66971968
95mRNA surveillance pathway_Homo sapiens_hsa030150.66545217
96Cocaine addiction_Homo sapiens_hsa050300.65531124
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65500744
98Huntingtons disease_Homo sapiens_hsa050160.64456452
99Long-term depression_Homo sapiens_hsa047300.64102402
100Oxidative phosphorylation_Homo sapiens_hsa001900.63312872
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63296500
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62638663
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60569943
104Malaria_Homo sapiens_hsa051440.59572247
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58163850
106Shigellosis_Homo sapiens_hsa051310.57710427
107cAMP signaling pathway_Homo sapiens_hsa040240.57017406
108Vitamin digestion and absorption_Homo sapiens_hsa049770.56314335
109Salivary secretion_Homo sapiens_hsa049700.55773596
110Regulation of autophagy_Homo sapiens_hsa041400.55061628
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54779596
112Oxytocin signaling pathway_Homo sapiens_hsa049210.54764272
113Ether lipid metabolism_Homo sapiens_hsa005650.54646318
114Apoptosis_Homo sapiens_hsa042100.53996411
115Vitamin B6 metabolism_Homo sapiens_hsa007500.53714994
116Melanoma_Homo sapiens_hsa052180.52430312
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51910664
118Pertussis_Homo sapiens_hsa051330.51484702
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51405323
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51059738
121Glutathione metabolism_Homo sapiens_hsa004800.49292645
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.49040079
123Viral carcinogenesis_Homo sapiens_hsa052030.48970758
124Hepatitis B_Homo sapiens_hsa051610.48521621
125HTLV-I infection_Homo sapiens_hsa051660.48370251
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48178707
127Gastric acid secretion_Homo sapiens_hsa049710.46876142
128Axon guidance_Homo sapiens_hsa043600.46720106
129Hedgehog signaling pathway_Homo sapiens_hsa043400.44759588
130Sulfur relay system_Homo sapiens_hsa041220.43982930
131Pentose phosphate pathway_Homo sapiens_hsa000300.42604294
132Alcoholism_Homo sapiens_hsa050340.40604154
133Ras signaling pathway_Homo sapiens_hsa040140.39883316
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38810366
135Rheumatoid arthritis_Homo sapiens_hsa053230.38809314
136Glycerolipid metabolism_Homo sapiens_hsa005610.38302449
137Selenocompound metabolism_Homo sapiens_hsa004500.38045372
138Type II diabetes mellitus_Homo sapiens_hsa049300.37755961
139T cell receptor signaling pathway_Homo sapiens_hsa046600.37160079
140* Metabolic pathways_Homo sapiens_hsa011000.36030168
141Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34815746
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34516464
143Sphingolipid metabolism_Homo sapiens_hsa006000.33946227
144Galactose metabolism_Homo sapiens_hsa000520.33364236
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32184268
146MAPK signaling pathway_Homo sapiens_hsa040100.31174437
147TNF signaling pathway_Homo sapiens_hsa046680.31035231
148Acute myeloid leukemia_Homo sapiens_hsa052210.30692866
149Osteoclast differentiation_Homo sapiens_hsa043800.28845873
150Notch signaling pathway_Homo sapiens_hsa043300.28818156
151beta-Alanine metabolism_Homo sapiens_hsa004100.28777672
152B cell receptor signaling pathway_Homo sapiens_hsa046620.28225093
153Chemokine signaling pathway_Homo sapiens_hsa040620.27784552
154Steroid biosynthesis_Homo sapiens_hsa001000.27476933
155Glycosaminoglycan degradation_Homo sapiens_hsa005310.26603473
156Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26358235
157Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25576606
158Salmonella infection_Homo sapiens_hsa051320.24871116
159Alzheimers disease_Homo sapiens_hsa050100.24055115
160Hepatitis C_Homo sapiens_hsa051600.23823811
161Fatty acid elongation_Homo sapiens_hsa000620.22388605
162Small cell lung cancer_Homo sapiens_hsa052220.22203915
163Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22025516

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