PIGY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of the GPI-N-acetylglucosaminyltransferase (GIP-GnT) complex which initiates the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is synthesized in the endoplasmic reticulum and serves as an anchor for many surface proteins. Proteins containing GPI anchors can have an important role in cell-cell interactions. The transcript for this gene is bicistronic. The downstream open reading frame encodes this GPI-GnT complex protein, while the upstream open reading frame encodes a protein with unknown function, as represented by GeneID:100996939. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)8.38494325
2cytidine metabolic process (GO:0046087)8.38494325
3cytidine catabolic process (GO:0006216)8.38494325
4pyrimidine ribonucleoside catabolic process (GO:0046133)7.62555678
5DNA deamination (GO:0045006)7.33184234
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.91656447
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.83254824
8actin nucleation (GO:0045010)5.00313234
9negative regulation by host of viral transcription (GO:0043922)4.92806444
10positive regulation of interleukin-8 secretion (GO:2000484)4.83105891
11regulation of activation of Janus kinase activity (GO:0010533)4.79464345
12positive regulation of B cell differentiation (GO:0045579)4.22563585
13DNA demethylation (GO:0080111)4.00553128
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.97535990
15regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.92864119
16pyrimidine nucleoside catabolic process (GO:0046135)3.91651347
17negative T cell selection (GO:0043383)3.78866990
18sequestering of actin monomers (GO:0042989)3.76327227
19eosinophil chemotaxis (GO:0048245)3.72268333
20regulation of B cell receptor signaling pathway (GO:0050855)3.71504802
21DNA dealkylation (GO:0035510)3.70456504
22regulation of T cell tolerance induction (GO:0002664)3.67865681
23regulation of interleukin-8 secretion (GO:2000482)3.66295780
24positive thymic T cell selection (GO:0045059)3.65060872
25T cell migration (GO:0072678)3.57419041
26pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.56897354
27positive regulation of calcium-mediated signaling (GO:0050850)3.51656061
28ATP synthesis coupled proton transport (GO:0015986)3.44124353
29energy coupled proton transport, down electrochemical gradient (GO:0015985)3.44124353
30eosinophil migration (GO:0072677)3.39798848
31positive T cell selection (GO:0043368)3.38950404
32base-excision repair, AP site formation (GO:0006285)3.36297540
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.35595118
34positive regulation of lymphocyte migration (GO:2000403)3.35409235
35protein polyglutamylation (GO:0018095)3.34005410
36regulation of alpha-beta T cell proliferation (GO:0046640)3.33734781
37negative regulation of B cell proliferation (GO:0030889)3.32512631
38regulation of B cell differentiation (GO:0045577)3.26538273
39pyrimidine nucleotide catabolic process (GO:0006244)3.26031854
40regulation of cellular amino acid metabolic process (GO:0006521)3.23505112
41macrophage chemotaxis (GO:0048246)3.23036452
42negative regulation of T cell apoptotic process (GO:0070233)3.21972886
43pyrimidine-containing compound catabolic process (GO:0072529)3.21833357
44positive regulation of monocyte chemotaxis (GO:0090026)3.21159564
45respiratory electron transport chain (GO:0022904)3.17729488
46regulation of chronic inflammatory response (GO:0002676)3.17398694
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16268176
48positive regulation of T cell apoptotic process (GO:0070234)3.15156311
49regulation of tolerance induction (GO:0002643)3.15087057
50estrogen biosynthetic process (GO:0006703)3.14848509
51T cell costimulation (GO:0031295)3.13852112
52cytolysis (GO:0019835)3.13040179
53positive regulation of tolerance induction (GO:0002645)3.12558805
54negative regulation of sodium ion transport (GO:0010766)3.11814576
55negative thymic T cell selection (GO:0045060)3.11130713
56cellular response to interleukin-15 (GO:0071350)3.10638841
57negative regulation of viral genome replication (GO:0045071)3.10282531
58electron transport chain (GO:0022900)3.09997180
59lymphocyte costimulation (GO:0031294)3.09934244
60regulation of lymphocyte chemotaxis (GO:1901623)3.08010410
61proteasome assembly (GO:0043248)3.07343161
62regulation of T cell receptor signaling pathway (GO:0050856)3.03989714
63protein complex biogenesis (GO:0070271)3.03700635
64positive regulation of alpha-beta T cell proliferation (GO:0046641)3.01617325
65lymphocyte chemotaxis (GO:0048247)3.00563299
66positive regulation of gamma-delta T cell activation (GO:0046645)3.00037878
67positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.97328406
68T cell receptor signaling pathway (GO:0050852)2.96468520
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.95024400
70deoxyribose phosphate catabolic process (GO:0046386)2.93657144
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93447204
72modulation by host of viral transcription (GO:0043921)2.86303486
73modulation by host of symbiont transcription (GO:0052472)2.86303486
74deoxyribonucleotide catabolic process (GO:0009264)2.85405955
75positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.85370391
76signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83414358
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83414358
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81935369
79regulation of regulatory T cell differentiation (GO:0045589)2.81906299
80platelet dense granule organization (GO:0060155)2.81762445
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.80060472
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.80060472
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.80060472
84autophagic vacuole fusion (GO:0000046)2.79810087
85thymic T cell selection (GO:0045061)2.78098213
86positive regulation of defense response to virus by host (GO:0002230)2.77398034
87modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.76906750
88regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.76567372
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.75299781
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.73680181
91positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.73385448
92positive regulation of T cell migration (GO:2000406)2.72959814
93positive regulation of natural killer cell mediated immunity (GO:0002717)2.72504082
94negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.72073248
95mast cell activation (GO:0045576)2.71608459
96antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.70611663
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.66905293
98protein neddylation (GO:0045116)2.65584034
99* GPI anchor biosynthetic process (GO:0006506)2.65391214
100mitochondrial respiratory chain complex assembly (GO:0033108)2.63726002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.01620699
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.47671405
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.66580586
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.99247157
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.29584287
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19536942
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.05617464
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.94043477
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.89555875
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69770731
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.57031811
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43768420
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.38036017
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.37049895
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.32453719
16VDR_23849224_ChIP-Seq_CD4+_Human2.29090794
17MYB_26560356_Chip-Seq_TH2_Human2.18254591
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16003682
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09926663
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05796139
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92055046
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.90078515
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.89683783
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89116167
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88641883
26FOXP3_21729870_ChIP-Seq_TREG_Human1.87335291
27VDR_22108803_ChIP-Seq_LS180_Human1.79382877
28RUNX_20019798_ChIP-Seq_JUKART_Human1.71818850
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65191162
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61934143
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53202332
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52947583
33* SRF_21415370_ChIP-Seq_HL-1_Mouse1.46656630
34* GATA3_26560356_Chip-Seq_TH2_Human1.45999729
35GATA3_27048872_Chip-Seq_THYMUS_Human1.44224716
36HTT_18923047_ChIP-ChIP_STHdh_Human1.43450226
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41241195
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39405863
39MYB_26560356_Chip-Seq_TH1_Human1.35787016
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34998336
41PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.32735263
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30304422
43ELK1_19687146_ChIP-ChIP_HELA_Human1.29595464
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26638767
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.24108379
46SCL_19346495_ChIP-Seq_HPC-7_Human1.23316739
47SPI1_23547873_ChIP-Seq_NB4_Human1.20584962
48UTX_26944678_Chip-Seq_JUKART_Human1.19687305
49TP53_22573176_ChIP-Seq_HFKS_Human1.18947906
50BCL6_27268052_Chip-Seq_Bcells_Human1.18347554
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14540391
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13246995
53AR_20517297_ChIP-Seq_VCAP_Human1.10165575
54CIITA_25753668_ChIP-Seq_RAJI_Human1.09824214
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09715654
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09188340
57EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07021778
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05676568
59NANOG_20526341_ChIP-Seq_ESCs_Human1.05049289
60P300_27268052_Chip-Seq_Bcells_Human1.03414369
61FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01744467
62PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99653627
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99497163
64ZNF274_21170338_ChIP-Seq_K562_Hela0.98244342
65SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97038447
66ERG_20517297_ChIP-Seq_VCAP_Human0.96896303
67NOTCH1_21737748_ChIP-Seq_TLL_Human0.96665580
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95941994
69CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95450962
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95401182
71MAF_26560356_Chip-Seq_TH2_Human0.94965798
72TAF15_26573619_Chip-Seq_HEK293_Human0.92307316
73TAF2_19829295_ChIP-Seq_ESCs_Human0.92256980
74EZH2_22144423_ChIP-Seq_EOC_Human0.91590717
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90870377
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90821376
77TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90217378
78RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89727687
79FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88757672
80FOXA1_25329375_ChIP-Seq_VCAP_Human0.88757672
81NCOR_22424771_ChIP-Seq_293T_Human0.88378981
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88204765
83CTCF_20526341_ChIP-Seq_ESCs_Human0.87703346
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86153484
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85625137
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84961964
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.84458542
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82831614
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.82722493
90GATA1_22025678_ChIP-Seq_K562_Human0.81469970
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80558079
92YY1_21170310_ChIP-Seq_MESCs_Mouse0.80050044
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79886167
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.79562485
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78951661
96MYC_18940864_ChIP-ChIP_HL60_Human0.78748570
97FLI1_27457419_Chip-Seq_LIVER_Mouse0.78582424
98CREB1_15753290_ChIP-ChIP_HEK293T_Human0.78441892
99GATA3_26560356_Chip-Seq_TH1_Human0.77749692
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.75969756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.79127048
2MP0001835_abnormal_antigen_presentation3.39298252
3MP0003763_abnormal_thymus_physiology3.28053959
4MP0009785_altered_susceptibility_to2.91338987
5MP0009333_abnormal_splenocyte_physiolog2.81192112
6MP0005000_abnormal_immune_tolerance2.44506281
7MP0004147_increased_porphyrin_level2.36034210
8MP0003806_abnormal_nucleotide_metabolis2.34285245
9MP0002148_abnormal_hypersensitivity_rea2.32698150
10MP0000465_gastrointestinal_hemorrhage2.31684139
11MP0005075_abnormal_melanosome_morpholog2.24816006
12MP0001800_abnormal_humoral_immune2.18929862
13MP0005025_abnormal_response_to2.18624776
14MP0005464_abnormal_platelet_physiology2.11540185
15MP0002723_abnormal_immune_serum2.06559679
16MP0002420_abnormal_adaptive_immunity2.00983020
17MP0001819_abnormal_immune_cell2.00191382
18MP0005451_abnormal_body_composition1.99321828
19MP0006082_CNS_inflammation1.96009780
20MP0002166_altered_tumor_susceptibility1.85645989
21MP0002452_abnormal_antigen_presenting1.81520053
22MP0002837_dystrophic_cardiac_calcinosis1.79434168
23MP0006072_abnormal_retinal_apoptosis1.77745577
24MP0001919_abnormal_reproductive_system1.76187326
25MP0002398_abnormal_bone_marrow1.75717835
26MP0009379_abnormal_foot_pigmentation1.73095719
27MP0002163_abnormal_gland_morphology1.68725676
28MP0002876_abnormal_thyroid_physiology1.66787613
29MP0008875_abnormal_xenobiotic_pharmacok1.61956589
30MP0000716_abnormal_immune_system1.61486036
31MP0005389_reproductive_system_phenotype1.60990772
32MP0001905_abnormal_dopamine_level1.59335767
33MP0005645_abnormal_hypothalamus_physiol1.56785038
34MP0001790_abnormal_immune_system1.55063985
35MP0005387_immune_system_phenotype1.55063985
36MP0000372_irregular_coat_pigmentation1.54610227
37MP0000015_abnormal_ear_pigmentation1.54062844
38MP0005084_abnormal_gallbladder_morpholo1.48939402
39MP0002102_abnormal_ear_morphology1.46554014
40MP0002095_abnormal_skin_pigmentation1.44448821
41MP0002006_tumorigenesis1.41461923
42MP0006036_abnormal_mitochondrial_physio1.40809315
43MP0002822_catalepsy1.39718890
44MP0010155_abnormal_intestine_physiology1.39082805
45MP0005646_abnormal_pituitary_gland1.38578314
46MP0003866_abnormal_defecation1.36409819
47MP0005174_abnormal_tail_pigmentation1.34050718
48MP0002405_respiratory_system_inflammati1.32565521
49MP0000689_abnormal_spleen_morphology1.30340718
50MP0003436_decreased_susceptibility_to1.30147538
51MP0003075_altered_response_to1.29902262
52MP0002429_abnormal_blood_cell1.29070959
53MP0001845_abnormal_inflammatory_respons1.26624496
54MP0004145_abnormal_muscle_electrophysio1.26105044
55MP0002419_abnormal_innate_immunity1.24898601
56MP0002722_abnormal_immune_system1.22818301
57MP0008469_abnormal_protein_level1.19724828
58MP0000703_abnormal_thymus_morphology1.19373121
59MP0008789_abnormal_olfactory_epithelium1.18694806
60MP0000569_abnormal_digit_pigmentation1.18202238
61MP0009764_decreased_sensitivity_to1.18043659
62MP0008872_abnormal_physiological_respon1.16844959
63MP0005636_abnormal_mineral_homeostasis1.14752739
64MP0002160_abnormal_reproductive_system1.09480426
65MP0003186_abnormal_redox_activity1.06888007
66MP0005253_abnormal_eye_physiology1.06049028
67MP0009697_abnormal_copulation1.05386372
68MP0001968_abnormal_touch/_nociception1.03345367
69MP0001853_heart_inflammation1.02880414
70MP0009763_increased_sensitivity_to1.00900093
71MP0005551_abnormal_eye_electrophysiolog0.99605079
72MP0005166_decreased_susceptibility_to0.98113209
73MP0002132_abnormal_respiratory_system0.97379288
74MP0003786_premature_aging0.94280978
75MP0005085_abnormal_gallbladder_physiolo0.93848373
76MP0005410_abnormal_fertilization0.93184993
77MP0009643_abnormal_urine_homeostasis0.92071970
78MP0003448_altered_tumor_morphology0.91505853
79MP0000685_abnormal_immune_system0.91033861
80MP0001765_abnormal_ion_homeostasis0.90707937
81MP0008995_early_reproductive_senescence0.90033286
82MP0003195_calcinosis0.89420274
83MP0000681_abnormal_thyroid_gland0.88134668
84MP0001501_abnormal_sleep_pattern0.84100739
85MP0002019_abnormal_tumor_incidence0.83782447
86MP0001873_stomach_inflammation0.83684350
87MP0003045_fibrosis0.81135942
88MP0005379_endocrine/exocrine_gland_phen0.81120492
89MP0010386_abnormal_urinary_bladder0.79529610
90MP0009765_abnormal_xenobiotic_induced0.78207696
91MP0008058_abnormal_DNA_repair0.76621389
92MP0003011_delayed_dark_adaptation0.76482408
93MP0003787_abnormal_imprinting0.74924071
94MP0001664_abnormal_digestion0.71827750
95MP0001542_abnormal_bone_strength0.71411709
96MP0002277_abnormal_respiratory_mucosa0.71220409
97MP0005360_urolithiasis0.71026227
98MP0003656_abnormal_erythrocyte_physiolo0.69866797
99MP0002933_joint_inflammation0.69123558
100MP0005584_abnormal_enzyme/coenzyme_acti0.68880469

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.60692197
2Aplastic anemia (HP:0001915)4.47538598
3Abnormality of T cell number (HP:0011839)4.40263276
4Severe combined immunodeficiency (HP:0004430)3.93620206
5Increased intramyocellular lipid droplets (HP:0012240)3.79386028
6Reduced antithrombin III activity (HP:0001976)3.71346426
7Hepatocellular necrosis (HP:0001404)3.56339451
8Abnormality of the prostate (HP:0008775)3.56101704
9Mitochondrial inheritance (HP:0001427)3.54269796
10Chronic obstructive pulmonary disease (HP:0006510)3.46274124
11Obstructive lung disease (HP:0006536)3.46274124
12Autoimmune hemolytic anemia (HP:0001890)3.38678508
13Hypoproteinemia (HP:0003075)3.37621721
14IgG deficiency (HP:0004315)3.24490204
15Abnormal mitochondria in muscle tissue (HP:0008316)3.24287450
16Hepatic necrosis (HP:0002605)3.22012559
17Increased muscle lipid content (HP:0009058)3.21110250
18Acute necrotizing encephalopathy (HP:0006965)3.20895824
19Abnormality of T cells (HP:0002843)3.17703921
203-Methylglutaconic aciduria (HP:0003535)3.12317351
21Increased IgM level (HP:0003496)3.03519729
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.02490156
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.02490156
24Cerebral palsy (HP:0100021)2.97975264
25Combined immunodeficiency (HP:0005387)2.96575853
26Increased CSF lactate (HP:0002490)2.91344491
27Increased hepatocellular lipid droplets (HP:0006565)2.89527715
28Thyroiditis (HP:0100646)2.87944857
29Abnormality of eosinophils (HP:0001879)2.79338245
30Chronic diarrhea (HP:0002028)2.71447812
31Lipid accumulation in hepatocytes (HP:0006561)2.63510550
32Progressive macrocephaly (HP:0004481)2.59314964
33Acute encephalopathy (HP:0006846)2.56825162
34Meningitis (HP:0001287)2.54923576
35Oral leukoplakia (HP:0002745)2.52040582
36Elevated erythrocyte sedimentation rate (HP:0003565)2.49726376
37Renal Fanconi syndrome (HP:0001994)2.47559856
38Ureteral stenosis (HP:0000071)2.45197202
39Chest pain (HP:0100749)2.43366421
40Pulmonary fibrosis (HP:0002206)2.41142269
41Severe visual impairment (HP:0001141)2.38491716
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.38063012
43Exertional dyspnea (HP:0002875)2.36558978
44Granulocytopenia (HP:0001913)2.34428713
45Panhypogammaglobulinemia (HP:0003139)2.31904555
46Eosinophilia (HP:0001880)2.31545830
47Ureteral obstruction (HP:0006000)2.29477246
48Metaphyseal dysplasia (HP:0100255)2.28606410
49Gastrointestinal infarctions (HP:0005244)2.26866792
50Gangrene (HP:0100758)2.24177963
51Abnormality of B cell number (HP:0010975)2.20824032
52Hypothermia (HP:0002045)2.19966655
53B lymphocytopenia (HP:0010976)2.19708656
54Skin rash (HP:0000988)2.18836683
55Encephalitis (HP:0002383)2.17787717
56Abnormal rod and cone electroretinograms (HP:0008323)2.17328522
57Joint swelling (HP:0001386)2.16779742
58Abnormal number of erythroid precursors (HP:0012131)2.15534664
59Pulmonary infiltrates (HP:0002113)2.14828332
60Leukocytosis (HP:0001974)2.14253044
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12505840
62Abnormal protein N-linked glycosylation (HP:0012347)2.12505840
63Abnormal protein glycosylation (HP:0012346)2.12505840
64Abnormal glycosylation (HP:0012345)2.12505840
65Agammaglobulinemia (HP:0004432)2.11891894
66Recurrent fungal infections (HP:0002841)2.10726035
67Abnormality of the pleura (HP:0002103)2.09019697
68Abolished electroretinogram (ERG) (HP:0000550)2.08419657
69Hemoptysis (HP:0002105)2.08398538
70Chronic mucocutaneous candidiasis (HP:0002728)2.06674046
71Recurrent cutaneous fungal infections (HP:0011370)2.06674046
72Cerebral edema (HP:0002181)2.06320026
73Lactic acidosis (HP:0003128)2.05537118
74Vasculitis (HP:0002633)2.05210017
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04887375
76Medial flaring of the eyebrow (HP:0010747)2.03557449
77Abnormality of cells of the erythroid lineage (HP:0012130)2.03534651
78Abnormality of macular pigmentation (HP:0008002)2.03427525
79Abnormality of midbrain morphology (HP:0002418)2.03259070
80Molar tooth sign on MRI (HP:0002419)2.03259070
81Microretrognathia (HP:0000308)2.02880824
82Optic disc pallor (HP:0000543)2.02679324
83Increased serum lactate (HP:0002151)2.02523498
84Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02211139
85Epistaxis (HP:0000421)1.98820197
86Sensory axonal neuropathy (HP:0003390)1.95696762
87Abnormality of male internal genitalia (HP:0000022)1.93270508
88Abnormality of the phalanges of the 2nd finger (HP:0009541)1.92363957
89Hypoplasia of the thymus (HP:0000778)1.91549671
90Dicarboxylic aciduria (HP:0003215)1.91227102
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91227102
92Amaurosis fugax (HP:0100576)1.91065031
93Renal cortical cysts (HP:0000803)1.90324670
94Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88028973
95Congenital stationary night blindness (HP:0007642)1.87097198
96Premature graying of hair (HP:0002216)1.86183469
97Recurrent skin infections (HP:0001581)1.83363154
98Abnormality of T cell physiology (HP:0011840)1.82101624
99Abnormality of the columella (HP:0009929)1.81685889
100Gingival bleeding (HP:0000225)1.79015177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.21379283
2TESK24.76324058
3KDR4.49215358
4MAP3K123.70813636
5VRK23.67114920
6TLK12.61985346
7ZAK2.29080683
8MAP4K12.26570789
9DAPK22.22725684
10BCKDK2.14334771
11VRK12.05946219
12SCYL22.01427913
13DAPK12.00919784
14TAOK31.97578829
15TESK11.91387108
16PIM21.90720611
17ITK1.83006038
18NUAK11.77024266
19STK161.65374757
20MAP3K111.58859540
21ADRBK21.47381572
22SYK1.39459790
23GRK61.38922603
24MYLK1.34519325
25BMPR21.31019304
26FES1.29431870
27MST41.26177152
28DAPK31.21953790
29LIMK11.20097634
30PRKCQ1.18510875
31KIT1.14195864
32ZAP701.14163931
33TNK21.11309735
34MAP4K21.10191414
35GRK71.08019458
36RIPK41.06432162
37RPS6KA41.04242487
38BMPR1B1.03303655
39IKBKB0.97787409
40LCK0.93683880
41TEC0.92169057
42BUB10.88322598
43PIM10.85852097
44RPS6KA50.85042633
45CCNB10.84990920
46TAF10.82596120
47CAMKK20.79733858
48ILK0.78838297
49CDK190.77231756
50LYN0.75175984
51MAP2K70.72205902
52MAP3K50.68003906
53CSF1R0.67961086
54CSNK1G30.67910111
55CSK0.67642784
56TIE10.63942254
57IKBKE0.62542613
58AURKA0.61573112
59ABL20.58557987
60GRK10.58131314
61MAPKAPK30.55735827
62GRK50.55209912
63ERBB30.54091259
64BTK0.53519160
65CSNK1G10.52728810
66ERN10.51528561
67MUSK0.48340602
68INSRR0.48208079
69JAK30.48185148
70OBSCN0.45669119
71ROCK10.45603872
72ARAF0.42917726
73PIK3CG0.41740791
74FRK0.40988205
75MAP2K60.40122822
76CSNK1G20.39417528
77DYRK20.38493433
78WNK40.38481019
79FYN0.37058329
80BLK0.36382539
81PIK3CA0.35913938
82ATR0.34295006
83PRKACA0.33826172
84TBK10.33585293
85PRKCA0.33353719
86MATK0.31677128
87TYK20.31502558
88BRSK10.31256093
89CSNK1A1L0.30943026
90PRKCD0.30881774
91BRSK20.30259434
92IGF1R0.29526690
93CSNK2A10.29317346
94JAK20.28611820
95PKN10.28082860
96CSNK2A20.27162520
97CDK80.26114298
98MAPKAPK50.25568666
99CSNK1A10.24989766
100MAPK110.24539907

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.26793663
2Primary immunodeficiency_Homo sapiens_hsa053404.08999837
3Proteasome_Homo sapiens_hsa030503.84800691
4Autoimmune thyroid disease_Homo sapiens_hsa053203.80206002
5Allograft rejection_Homo sapiens_hsa053303.62592857
6Oxidative phosphorylation_Homo sapiens_hsa001903.26254813
7Type I diabetes mellitus_Homo sapiens_hsa049403.12722977
8Antigen processing and presentation_Homo sapiens_hsa046123.10561102
9Asthma_Homo sapiens_hsa053102.75191280
10Parkinsons disease_Homo sapiens_hsa050122.70255696
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.35225208
12Rheumatoid arthritis_Homo sapiens_hsa053232.25064421
13Ribosome_Homo sapiens_hsa030102.13782802
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.07675945
15Hematopoietic cell lineage_Homo sapiens_hsa046402.03340080
16Alzheimers disease_Homo sapiens_hsa050101.81286756
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65152863
18Viral myocarditis_Homo sapiens_hsa054161.62726866
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55025008
20Huntingtons disease_Homo sapiens_hsa050161.54520403
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45872398
22Protein export_Homo sapiens_hsa030601.43492887
23RNA polymerase_Homo sapiens_hsa030201.37596344
24T cell receptor signaling pathway_Homo sapiens_hsa046601.32356557
25Cardiac muscle contraction_Homo sapiens_hsa042601.30856521
26Staphylococcus aureus infection_Homo sapiens_hsa051501.17583020
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11218422
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06607478
29Systemic lupus erythematosus_Homo sapiens_hsa053221.05440404
30Salmonella infection_Homo sapiens_hsa051321.03186849
31Fatty acid elongation_Homo sapiens_hsa000620.99370716
32* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98965465
33Steroid hormone biosynthesis_Homo sapiens_hsa001400.97922302
34Peroxisome_Homo sapiens_hsa041460.95483512
35Nitrogen metabolism_Homo sapiens_hsa009100.94834929
36SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90452425
37Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88788624
38Collecting duct acid secretion_Homo sapiens_hsa049660.87826843
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85014134
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83148737
41NF-kappa B signaling pathway_Homo sapiens_hsa040640.82142874
42Phototransduction_Homo sapiens_hsa047440.81976950
43Measles_Homo sapiens_hsa051620.78607507
44Non-homologous end-joining_Homo sapiens_hsa034500.78344369
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78334596
46Shigellosis_Homo sapiens_hsa051310.74192689
47Leishmaniasis_Homo sapiens_hsa051400.73101223
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71103720
49Pyrimidine metabolism_Homo sapiens_hsa002400.70183950
50Linoleic acid metabolism_Homo sapiens_hsa005910.69362262
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66314674
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.62257624
53Chemical carcinogenesis_Homo sapiens_hsa052040.61856182
54Sulfur metabolism_Homo sapiens_hsa009200.60176784
55Homologous recombination_Homo sapiens_hsa034400.58868283
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57386963
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57127156
58Regulation of autophagy_Homo sapiens_hsa041400.56487508
59Selenocompound metabolism_Homo sapiens_hsa004500.55615554
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54406693
61Butanoate metabolism_Homo sapiens_hsa006500.52489979
62Retinol metabolism_Homo sapiens_hsa008300.51771013
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50851167
64Arachidonic acid metabolism_Homo sapiens_hsa005900.50154411
65Tryptophan metabolism_Homo sapiens_hsa003800.49135808
66Sulfur relay system_Homo sapiens_hsa041220.47721094
67Ether lipid metabolism_Homo sapiens_hsa005650.47281319
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46527288
69Pertussis_Homo sapiens_hsa051330.44307415
70Herpes simplex infection_Homo sapiens_hsa051680.43680998
71Caffeine metabolism_Homo sapiens_hsa002320.43007118
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42549875
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42045495
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41405110
75Tuberculosis_Homo sapiens_hsa051520.41278170
76Olfactory transduction_Homo sapiens_hsa047400.41267812
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.40493736
78Purine metabolism_Homo sapiens_hsa002300.37214134
79* Metabolic pathways_Homo sapiens_hsa011000.36046729
80Basal transcription factors_Homo sapiens_hsa030220.35732371
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33786534
82RNA degradation_Homo sapiens_hsa030180.33679854
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.32563771
84Nucleotide excision repair_Homo sapiens_hsa034200.31390015
85DNA replication_Homo sapiens_hsa030300.30871066
86Legionellosis_Homo sapiens_hsa051340.30660668
87Base excision repair_Homo sapiens_hsa034100.29678744
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27900647
89Phagosome_Homo sapiens_hsa041450.27466675
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24626380
91One carbon pool by folate_Homo sapiens_hsa006700.23347404
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22271043
93Tyrosine metabolism_Homo sapiens_hsa003500.20647453
94Spliceosome_Homo sapiens_hsa030400.20254932
95Glutathione metabolism_Homo sapiens_hsa004800.18092340
96Epstein-Barr virus infection_Homo sapiens_hsa051690.17046433
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16931873
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16356703
99Folate biosynthesis_Homo sapiens_hsa007900.16198398
100Fanconi anemia pathway_Homo sapiens_hsa034600.16126892

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »