PIGZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.65775720
2myelination (GO:0042552)6.48962680
3axon ensheathment (GO:0008366)6.47949222
4ensheathment of neurons (GO:0007272)6.47949222
5very-low-density lipoprotein particle assembly (GO:0034379)6.43079744
6plasma lipoprotein particle assembly (GO:0034377)6.33152774
7long-chain fatty acid biosynthetic process (GO:0042759)6.27704950
8protein-lipid complex assembly (GO:0065005)5.83694415
9protein carboxylation (GO:0018214)5.74059938
10peptidyl-glutamic acid carboxylation (GO:0017187)5.74059938
11negative regulation of fibrinolysis (GO:0051918)5.68571831
12low-density lipoprotein particle remodeling (GO:0034374)5.52864877
13regulation of cholesterol esterification (GO:0010872)5.36554920
14myelin maintenance (GO:0043217)5.24414996
15intestinal cholesterol absorption (GO:0030299)5.21904477
16regulation of cholesterol homeostasis (GO:2000188)5.21634257
17intestinal absorption (GO:0050892)5.20185566
18plasma lipoprotein particle remodeling (GO:0034369)5.16536607
19protein-lipid complex remodeling (GO:0034368)5.16536607
20macromolecular complex remodeling (GO:0034367)5.16536607
21cholesterol efflux (GO:0033344)5.02233720
22high-density lipoprotein particle remodeling (GO:0034375)4.93827367
23regulation of fibrinolysis (GO:0051917)4.89284114
24plasma lipoprotein particle organization (GO:0071827)4.88924203
25establishment of mitochondrion localization (GO:0051654)4.77891525
26protein-lipid complex subunit organization (GO:0071825)4.70688041
27regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.61832000
28negative regulation of neurotransmitter transport (GO:0051589)4.61081593
29negative regulation of protein localization to cell surface (GO:2000009)4.58142581
30reverse cholesterol transport (GO:0043691)4.51733508
31regulation of protein activation cascade (GO:2000257)4.49621032
32creatine metabolic process (GO:0006600)4.42986215
33oligodendrocyte differentiation (GO:0048709)4.41757709
34regulation of apoptotic cell clearance (GO:2000425)4.40253800
35negative regulation of neurotransmitter secretion (GO:0046929)4.40054384
36regulation of complement activation (GO:0030449)4.39060296
37triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.35580517
38regulation of collateral sprouting (GO:0048670)4.35037687
39plasma lipoprotein particle clearance (GO:0034381)4.32012718
40cholesterol biosynthetic process (GO:0006695)4.17542326
41presynaptic membrane organization (GO:0097090)4.12410634
42regulation of plasminogen activation (GO:0010755)4.10515648
43glycerophospholipid catabolic process (GO:0046475)4.10144987
44response to methylmercury (GO:0051597)4.06483065
45eye photoreceptor cell differentiation (GO:0001754)4.03944015
46photoreceptor cell differentiation (GO:0046530)4.03944015
47diacylglycerol metabolic process (GO:0046339)4.03895764
48apical protein localization (GO:0045176)4.02029337
49L-amino acid import (GO:0043092)4.01618086
50positive regulation of oligodendrocyte differentiation (GO:0048714)3.98415090
51asymmetric protein localization (GO:0008105)3.86799042
52amyloid precursor protein metabolic process (GO:0042982)3.84633264
53response to redox state (GO:0051775)3.77665815
54sterol biosynthetic process (GO:0016126)3.73777151
55L-phenylalanine metabolic process (GO:0006558)3.72235988
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.72235988
57phospholipid efflux (GO:0033700)3.71850450
58presynaptic membrane assembly (GO:0097105)3.69434066
59substantia nigra development (GO:0021762)3.67462005
60astrocyte development (GO:0014002)3.66605605
61regulation of cholesterol biosynthetic process (GO:0045540)3.66233375
62low-density lipoprotein particle clearance (GO:0034383)3.66208160
63blood coagulation, intrinsic pathway (GO:0007597)3.65338273
64long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.64147152
65positive regulation of triglyceride lipase activity (GO:0061365)3.62941097
66positive regulation of lipoprotein lipase activity (GO:0051006)3.62941097
67negative regulation of sterol transport (GO:0032372)3.59899405
68negative regulation of cholesterol transport (GO:0032375)3.59899405
69membrane tubulation (GO:0097320)3.58910274
70neuron cell-cell adhesion (GO:0007158)3.55280237
71lipoprotein metabolic process (GO:0042157)3.49752086
72positive regulation of extracellular matrix organization (GO:1903055)3.46113157
73long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.42566005
74regulation of bile acid biosynthetic process (GO:0070857)3.41160325
75cholesterol homeostasis (GO:0042632)3.40854658
76protein neddylation (GO:0045116)3.40219995
77positive regulation of steroid metabolic process (GO:0045940)3.39738362
78adult walking behavior (GO:0007628)3.37790037
79import into cell (GO:0098657)3.37490728
80response to lipoprotein particle (GO:0055094)3.37393672
81sterol homeostasis (GO:0055092)3.36564263
82isoprenoid biosynthetic process (GO:0008299)3.36149995
83proline metabolic process (GO:0006560)3.33737544
84protein palmitoylation (GO:0018345)3.33151414
85negative regulation of protein activation cascade (GO:2000258)3.31911407
86renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.29540421
87sterol transport (GO:0015918)3.27169280
88cholesterol transport (GO:0030301)3.27169280
89axon development (GO:0061564)3.22469788
90positive regulation of fatty acid biosynthetic process (GO:0045723)3.21349284
91regulation of cholesterol metabolic process (GO:0090181)3.17987564
92virion attachment to host cell (GO:0019062)3.15091432
93adhesion of symbiont to host cell (GO:0044650)3.15091432
94fatty-acyl-CoA biosynthetic process (GO:0046949)3.14840081
95negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.14450791
96regulation of extracellular matrix organization (GO:1903053)3.11181985
97lung epithelium development (GO:0060428)3.09236840
98regulation of lipoprotein metabolic process (GO:0050746)3.07192768
99neurotransmitter uptake (GO:0001504)3.06566731
100ethanol oxidation (GO:0006069)3.05041120
101fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.04233320
102glycosylceramide metabolic process (GO:0006677)3.03423419
103peptidyl-tyrosine autophosphorylation (GO:0038083)3.02399634
104regulation of extracellular matrix disassembly (GO:0010715)3.01849783
105fatty-acyl-CoA metabolic process (GO:0035337)3.00757667
106acylglycerol homeostasis (GO:0055090)3.00408413
107triglyceride homeostasis (GO:0070328)3.00408413
108limb bud formation (GO:0060174)2.99071813
109negative regulation of lipase activity (GO:0060192)2.98720848
110complement activation, alternative pathway (GO:0006957)2.98198751
111neuronal action potential propagation (GO:0019227)2.97165392
112glutamate metabolic process (GO:0006536)2.96939296
113acylglycerol catabolic process (GO:0046464)2.96913801
114neutral lipid catabolic process (GO:0046461)2.96913801
115proline biosynthetic process (GO:0006561)2.93223565
116amino acid import (GO:0043090)2.93171854
117negative regulation of JUN kinase activity (GO:0043508)2.91492712
118very long-chain fatty acid metabolic process (GO:0000038)2.90575603
119sulfate transmembrane transport (GO:1902358)2.89995218
120negative regulation of axonogenesis (GO:0050771)2.88701352
121acute-phase response (GO:0006953)2.88644994
122magnesium ion transport (GO:0015693)2.87404109
123lipid homeostasis (GO:0055088)2.86889103
124transmission of nerve impulse (GO:0019226)2.86632118
125enteric nervous system development (GO:0048484)2.86339443
126amyloid precursor protein catabolic process (GO:0042987)2.83481023
127detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.83470643
128detection of temperature stimulus involved in sensory perception (GO:0050961)2.83470643
129nephron tubule morphogenesis (GO:0072078)2.82853478
130nephron epithelium morphogenesis (GO:0072088)2.82853478
131negative regulation of macroautophagy (GO:0016242)2.80393323
132vitamin transmembrane transport (GO:0035461)2.80362467
133mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79195039
134cerebral cortex radially oriented cell migration (GO:0021799)2.78425578
135positive regulation of synapse maturation (GO:0090129)2.78249432
136peptidyl-cysteine modification (GO:0018198)2.78079766
137myelination in peripheral nervous system (GO:0022011)2.77738960
138peripheral nervous system axon ensheathment (GO:0032292)2.77738960
139cellular zinc ion homeostasis (GO:0006882)2.75801387
140negative regulation of blood coagulation (GO:0030195)2.75472665
141negative regulation of hemostasis (GO:1900047)2.75472665
142transepithelial transport (GO:0070633)2.73588958
143negative regulation of digestive system process (GO:0060457)2.73471005
144neuron remodeling (GO:0016322)2.73322434
145drinking behavior (GO:0042756)2.73011785
146positive regulation of lipid catabolic process (GO:0050996)2.72141251
147leukocyte migration involved in inflammatory response (GO:0002523)2.71625781
148nucleotide transmembrane transport (GO:1901679)2.71130787
149regulation of cholesterol storage (GO:0010885)2.70747679
150lipoprotein transport (GO:0042953)2.67771407
151negative regulation of synaptic transmission, GABAergic (GO:0032229)2.67742651
152preassembly of GPI anchor in ER membrane (GO:0016254)2.67157011
153protein activation cascade (GO:0072376)2.66711383
154regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.66443425
155negative regulation of complement activation (GO:0045916)2.66353790
156regulation of systemic arterial blood pressure by hormone (GO:0001990)2.66143366
157regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.66143366
158endocrine process (GO:0050886)2.66143366
159cellular response to epinephrine stimulus (GO:0071872)2.65803888
160negative regulation of sodium ion transport (GO:0010766)2.65778127
161positive regulation of action potential (GO:0045760)2.63828582
162angiotensin maturation (GO:0002003)2.63679128
163positive regulation of fatty acid beta-oxidation (GO:0032000)2.63317938
164dicarboxylic acid biosynthetic process (GO:0043650)2.62904563
165glial cell development (GO:0021782)2.62487120
166glutamine family amino acid biosynthetic process (GO:0009084)2.62027103
167receptor catabolic process (GO:0032801)2.61566468
168negative regulation of acute inflammatory response (GO:0002674)2.60676064
169regulation of dopamine metabolic process (GO:0042053)2.60528141
170regulation of catecholamine metabolic process (GO:0042069)2.60528141
171microtubule polymerization or depolymerization (GO:0031109)2.60199002
172negative regulation of execution phase of apoptosis (GO:1900118)2.60050856
173response to lead ion (GO:0010288)2.60048336
174regulation of fatty acid biosynthetic process (GO:0042304)2.56739907
175trivalent inorganic anion homeostasis (GO:0072506)2.55571607
176phosphate ion homeostasis (GO:0055062)2.55571607
177positive regulation of blood coagulation (GO:0030194)2.55094234
178positive regulation of hemostasis (GO:1900048)2.55094234
179NADH metabolic process (GO:0006734)2.54975009
180glutathione biosynthetic process (GO:0006750)2.53006151
181dopamine biosynthetic process (GO:0042416)2.52063204
182positive regulation of glial cell differentiation (GO:0045687)2.51528961
183peripheral nervous system development (GO:0007422)2.51196444
184* GPI anchor metabolic process (GO:0006505)2.49763788
185neural nucleus development (GO:0048857)2.48187379
186regulation of interleukin-13 production (GO:0032656)2.46254611
187membrane raft organization (GO:0031579)2.46101133
188nerve growth factor signaling pathway (GO:0038180)2.45499301
189* GPI anchor biosynthetic process (GO:0006506)2.45085242
190erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.44796698
191L-phenylalanine catabolic process (GO:0006559)2.44796698
192iron coordination entity transport (GO:1901678)2.43350702
193negative regulation of chemokine production (GO:0032682)2.41692080
194thioester biosynthetic process (GO:0035384)2.41225170
195acyl-CoA biosynthetic process (GO:0071616)2.41225170
196cranial nerve development (GO:0021545)2.40982034
197central nervous system myelination (GO:0022010)11.5950953
198axon ensheathment in central nervous system (GO:0032291)11.5950953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.85511754
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.70733869
3GBX2_23144817_ChIP-Seq_PC3_Human3.66679159
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.59918932
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.44529568
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.25089158
7EZH2_22144423_ChIP-Seq_EOC_Human2.96142380
8ZNF263_19887448_ChIP-Seq_K562_Human2.87045404
9* FOXA2_19822575_ChIP-Seq_HepG2_Human2.80114211
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.76570447
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.71041611
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.66906647
13SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.59113795
14TAF15_26573619_Chip-Seq_HEK293_Human2.53998311
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.45381593
16* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45348998
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.38726863
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.37116768
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.36153137
20* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35024886
21LXR_22292898_ChIP-Seq_THP-1_Human2.30071615
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.22952991
23JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22023580
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14716271
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07728702
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.04595941
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03259541
28RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01917126
29EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01917126
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.00670590
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00603910
32EZH2_27304074_Chip-Seq_ESCs_Mouse2.00014277
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.99398119
34HNF4A_19822575_ChIP-Seq_HepG2_Human1.99259463
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97170990
36* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96949696
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95719806
38* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93419880
39CLOCK_20551151_ChIP-Seq_293T_Human1.90022138
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86730406
41* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83731484
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.83009025
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.82712117
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82219735
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.79874515
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.78466154
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78300504
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75491342
49AR_21572438_ChIP-Seq_LNCaP_Human1.72198310
50ER_23166858_ChIP-Seq_MCF-7_Human1.71340385
51RACK7_27058665_Chip-Seq_MCF-7_Human1.69602538
52VDR_22108803_ChIP-Seq_LS180_Human1.67562791
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.67556758
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.66581663
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.61972901
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.61263281
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61154489
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60334370
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58603298
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58426965
61* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.58031370
62SOX2_27498859_Chip-Seq_STOMACH_Mouse1.57449850
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.56953116
64DROSHA_22980978_ChIP-Seq_HELA_Human1.56843910
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56025194
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55075306
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.50928367
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.50233536
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48986426
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47117005
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46735610
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46460462
73* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45244070
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.45067994
75GATA4_25053715_ChIP-Seq_YYC3_Human1.42863335
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.41383712
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41380088
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41221006
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40188420
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40142939
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39424093
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.39122733
83GATA6_25053715_ChIP-Seq_YYC3_Human1.38822357
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.38552256
85KDM2B_26808549_Chip-Seq_K562_Human1.34441317
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33490068
87P68_20966046_ChIP-Seq_HELA_Human1.32452978
88REST_21632747_ChIP-Seq_MESCs_Mouse1.30944407
89TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.30916971
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30326561
91SOX2_20726797_ChIP-Seq_SW620_Human1.29948852
92P300_19829295_ChIP-Seq_ESCs_Human1.29870958
93SMC4_20622854_ChIP-Seq_HELA_Human1.27799877
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27694042
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26339835
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25728842
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25251010
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21630494
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19947683
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18873102
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18710989
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18542187
103RARB_27405468_Chip-Seq_BRAIN_Mouse1.18308352
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17941673
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17292670
106NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17292670
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16746058
108RUNX1_27514584_Chip-Seq_MCF-7_Human1.15338535
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14521462
110TET1_21451524_ChIP-Seq_MESCs_Mouse1.14117348
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13618123
112IGF1R_20145208_ChIP-Seq_DFB_Human1.13112458
113CREB1_26743006_Chip-Seq_LNCaP_Human1.12441657
114* CTCF_27219007_Chip-Seq_Bcells_Human1.12242825
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12063651
116TAL1_26923725_Chip-Seq_HPCs_Mouse1.12010607
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11708174
118TCF4_18268006_ChIP-ChIP_LS174T_Human1.11263237
119GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.11247279
120SMAD4_21799915_ChIP-Seq_A2780_Human1.11232202
121FUS_26573619_Chip-Seq_HEK293_Human1.11075629
122CMYC_18555785_Chip-Seq_ESCs_Mouse1.10591674
123REST_18959480_ChIP-ChIP_MESCs_Mouse1.09913461
124EOMES_21245162_ChIP-Seq_HESCs_Human1.09720077
125STAT3_23295773_ChIP-Seq_U87_Human1.09628943
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.08870193
127PRDM14_20953172_ChIP-Seq_ESCs_Human1.08592237
128LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07536079
129* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07284901
130KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07084607
131RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06912496
132SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05740810
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05239696
134SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02965626
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02447845
136TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02169571
137STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.01959946
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01243495
139P300_18555785_Chip-Seq_ESCs_Mouse1.01123543
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00329227
141TP53_22127205_ChIP-Seq_IMR90_Human1.00220902
142P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98726190
143MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98219190
144ELK3_25401928_ChIP-Seq_HUVEC_Human0.98070018
145RNF2_27304074_Chip-Seq_NSC_Mouse0.97934717
146EP300_21415370_ChIP-Seq_HL-1_Mouse0.97615548
147TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97481012
148CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97460005
149RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97402753
150WT1_19549856_ChIP-ChIP_CCG9911_Human0.96852403
151* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96817872
152TCF4_23295773_ChIP-Seq_U87_Human0.96733206
153NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96526254
154KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95855794
155EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95825269
156LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95329931
157TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95256445
158RARB_24833708_ChIP-Seq_LIVER_Mouse0.95062770
159NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94537079
160SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92964093
161SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92644879
162GATA1_19941827_ChIP-Seq_MEL_Mouse0.92186912
163AHR_22903824_ChIP-Seq_MCF-7_Human0.92060722
164* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91875259
165NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91846694
166FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91671864
167RARA_24833708_ChIP-Seq_LIVER_Mouse0.91378649
168GATA1_26923725_Chip-Seq_HPCs_Mouse0.91285078
169ARNT_22903824_ChIP-Seq_MCF-7_Human0.90666370
170EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90530129
171SOX2_19829295_ChIP-Seq_ESCs_Human0.90328201
172NANOG_19829295_ChIP-Seq_ESCs_Human0.90328201
173PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90255592
174GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89257356
175BCOR_27268052_Chip-Seq_Bcells_Human0.89058822
176SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88542952
177P53_22387025_ChIP-Seq_ESCs_Mouse0.88521158
178CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88458470
179WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87961471
180TP63_22573176_ChIP-Seq_HFKS_Human0.87807317
181TBL1_22424771_ChIP-Seq_293T_Human0.87118843
182RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86905210
183KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86430932
184KDM2B_26808549_Chip-Seq_REH_Human0.86386610
185RUNX1_27457419_Chip-Seq_LIVER_Mouse0.86189033
186* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85996598
187E2F1_18555785_Chip-Seq_ESCs_Mouse0.85977926
188TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85651265
189TCF7_22412390_ChIP-Seq_EML_Mouse0.85358531
190ATF3_27146783_Chip-Seq_COLON_Human0.83505886
191E2F1_20622854_ChIP-Seq_HELA_Human0.83458301
192SMC3_22415368_ChIP-Seq_MEFs_Mouse0.83131704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.19321121
2MP0005360_urolithiasis5.76208402
3MP0000920_abnormal_myelination5.21335842
4MP0005365_abnormal_bile_salt4.13344648
5MP0003880_abnormal_central_pattern4.11813293
6MP0003122_maternal_imprinting3.98542829
7MP0003950_abnormal_plasma_membrane3.96277512
8MP0010329_abnormal_lipoprotein_level3.65073371
9MP0004270_analgesia3.39914889
10MP0001666_abnormal_nutrient_absorption3.27533290
11MP0001529_abnormal_vocalization2.95290418
12MP0003690_abnormal_glial_cell2.91465126
13MP0003172_abnormal_lysosome_physiology2.88668256
14MP0009780_abnormal_chondrocyte_physiolo2.86560265
15MP0005085_abnormal_gallbladder_physiolo2.81548324
16MP0005171_absent_coat_pigmentation2.72207906
17MP0003123_paternal_imprinting2.71488251
18MP0003329_amyloid_beta_deposits2.71049939
19MP0002272_abnormal_nervous_system2.64454629
20MP0008875_abnormal_xenobiotic_pharmacok2.61978655
21MP0001905_abnormal_dopamine_level2.61434903
22MP0005670_abnormal_white_adipose2.54724054
23MP0004742_abnormal_vestibular_system2.53882230
24MP0001486_abnormal_startle_reflex2.46095331
25MP0004885_abnormal_endolymph2.39007572
26MP0002064_seizures2.37475499
27MP0004859_abnormal_synaptic_plasticity2.37367077
28MP0004142_abnormal_muscle_tone2.35984722
29MP0003634_abnormal_glial_cell2.27512502
30MP0003136_yellow_coat_color2.27302010
31MP0003868_abnormal_feces_composition2.22684744
32MP0001485_abnormal_pinna_reflex2.04967503
33MP0002734_abnormal_mechanical_nocicepti2.02562331
34MP0000778_abnormal_nervous_system1.98058527
35MP0004043_abnormal_pH_regulation1.96885905
36MP0003879_abnormal_hair_cell1.96466985
37MP0009046_muscle_twitch1.95979864
38MP0002089_abnormal_postnatal_growth/wei1.91050880
39MP0003635_abnormal_synaptic_transmissio1.89089786
40MP0009745_abnormal_behavioral_response1.88832945
41MP0002229_neurodegeneration1.86185289
42MP0005410_abnormal_fertilization1.80065966
43MP0002118_abnormal_lipid_homeostasis1.79793492
44MP0003632_abnormal_nervous_system1.73947189
45MP0010234_abnormal_vibrissa_follicle1.73784382
46MP0005409_darkened_coat_color1.71816527
47MP0005423_abnormal_somatic_nervous1.70232900
48MP0004264_abnormal_extraembryonic_tissu1.66195220
49MP0005451_abnormal_body_composition1.64453524
50MP0003183_abnormal_peptide_metabolism1.63195146
51MP0003252_abnormal_bile_duct1.61131541
52MP0001970_abnormal_pain_threshold1.59616440
53MP0002572_abnormal_emotion/affect_behav1.57077116
54MP0005332_abnormal_amino_acid1.51950640
55MP0008260_abnormal_autophagy1.51143670
56MP0002735_abnormal_chemical_nociception1.50363712
57MP0003191_abnormal_cellular_cholesterol1.49862627
58MP0004381_abnormal_hair_follicle1.49648650
59MP0000604_amyloidosis1.49569627
60MP0001440_abnormal_grooming_behavior1.47664730
61MP0003631_nervous_system_phenotype1.47436421
62MP0008569_lethality_at_weaning1.45469938
63MP0000609_abnormal_liver_physiology1.42490740
64MP0005551_abnormal_eye_electrophysiolog1.42339533
65MP0002063_abnormal_learning/memory/cond1.40197936
66MP0000955_abnormal_spinal_cord1.40042788
67MP0001968_abnormal_touch/_nociception1.36688292
68MP0002067_abnormal_sensory_capabilities1.35788436
69MP0002882_abnormal_neuron_morphology1.35202399
70MP0000462_abnormal_digestive_system1.34680838
71MP0003633_abnormal_nervous_system1.33907934
72MP0001756_abnormal_urination1.31394803
73MP0005636_abnormal_mineral_homeostasis1.30699377
74MP0003806_abnormal_nucleotide_metabolis1.30248717
75MP0001963_abnormal_hearing_physiology1.30244988
76MP0001765_abnormal_ion_homeostasis1.29904039
77MP0005257_abnormal_intraocular_pressure1.28728805
78MP0008438_abnormal_cutaneous_collagen1.28348227
79MP0002066_abnormal_motor_capabilities/c1.28298364
80MP0006054_spinal_hemorrhage1.27698810
81MP0002876_abnormal_thyroid_physiology1.27506679
82MP0002733_abnormal_thermal_nociception1.26725950
83MP0010678_abnormal_skin_adnexa1.24753536
84MP0001346_abnormal_lacrimal_gland1.23889957
85MP0005386_behavior/neurological_phenoty1.23501283
86MP0004924_abnormal_behavior1.23501283
87MP0004272_abnormal_basement_membrane1.23072507
88MP0004019_abnormal_vitamin_homeostasis1.21838379
89MP0002736_abnormal_nociception_after1.21581938
90MP0000003_abnormal_adipose_tissue1.19626743
91MP0000383_abnormal_hair_follicle1.18624115
92MP0002971_abnormal_brown_adipose1.18243092
93MP0002752_abnormal_somatic_nervous1.17758688
94MP0009384_cardiac_valve_regurgitation1.15598524
95MP0009643_abnormal_urine_homeostasis1.15483929
96MP0005408_hypopigmentation1.15467454
97MP0000747_muscle_weakness1.13274275
98MP0004147_increased_porphyrin_level1.13232701
99MP0004134_abnormal_chest_morphology1.12979211
100MP0005666_abnormal_adipose_tissue1.11472885
101MP0003195_calcinosis1.07081049
102MP0002909_abnormal_adrenal_gland1.05796148
103MP0005058_abnormal_lysosome_morphology1.02955769
104MP0000678_abnormal_parathyroid_gland1.02593666
105MP0000639_abnormal_adrenal_gland1.01682136
106MP0005375_adipose_tissue_phenotype1.00904006
107MP0001299_abnormal_eye_distance/0.96454257
108MP0005195_abnormal_posterior_eye0.95900041
109MP0000013_abnormal_adipose_tissue0.93453962
110MP0005645_abnormal_hypothalamus_physiol0.92277318
111MP0010368_abnormal_lymphatic_system0.90425175
112MP0001501_abnormal_sleep_pattern0.90413077
113MP0003866_abnormal_defecation0.90411354
114MP0003566_abnormal_cell_adhesion0.88419095
115MP0006082_CNS_inflammation0.88410666
116MP0002078_abnormal_glucose_homeostasis0.86979034
117MP0009115_abnormal_fat_cell0.86694612
118MP0001851_eye_inflammation0.86549951
119MP0001915_intracranial_hemorrhage0.86391946
120MP0005167_abnormal_blood-brain_barrier0.86117081
121MP0000026_abnormal_inner_ear0.86108600
122MP0002184_abnormal_innervation0.85745681
123MP0009840_abnormal_foam_cell0.85411347
124MP0003938_abnormal_ear_development0.84887865
125MP0005623_abnormal_meninges_morphology0.84402303
126MP0000762_abnormal_tongue_morphology0.83634438
127MP0006276_abnormal_autonomic_nervous0.82541480
128MP0004145_abnormal_muscle_electrophysio0.82237668
129MP0009642_abnormal_blood_homeostasis0.80985864
130MP0002295_abnormal_pulmonary_circulatio0.80637366
131MP0005584_abnormal_enzyme/coenzyme_acti0.79422974
132MP0001348_abnormal_lacrimal_gland0.79138845
133MP0005448_abnormal_energy_balance0.78867700
134MP0001661_extended_life_span0.77715378
135MP0000579_abnormal_nail_morphology0.77317203
136MP0002132_abnormal_respiratory_system0.77161733
137MP0000566_synostosis0.76932640
138MP0003953_abnormal_hormone_level0.76344501
139MP0001502_abnormal_circadian_rhythm0.75878711
140MP0002152_abnormal_brain_morphology0.74800141
141MP0002557_abnormal_social/conspecific_i0.73947443
142MP0000751_myopathy0.73246577
143MP0005253_abnormal_eye_physiology0.73208541
144MP0001270_distended_abdomen0.72970954
145MP0002896_abnormal_bone_mineralization0.72752433
146MP0003705_abnormal_hypodermis_morpholog0.72608688
147MP0003121_genomic_imprinting0.71659460
148MP0002090_abnormal_vision0.71346714
149MP0001177_atelectasis0.71205599
150MP0005319_abnormal_enzyme/_coenzyme0.71150696
151MP0000598_abnormal_liver_morphology0.70373337
152MP0005076_abnormal_cell_differentiation0.69540338
153MP0001986_abnormal_taste_sensitivity0.66210748
154MP0000749_muscle_degeneration0.65698469
155MP0000647_abnormal_sebaceous_gland0.65419757
156MP0004185_abnormal_adipocyte_glucose0.64519808
157MP0005646_abnormal_pituitary_gland0.64270777
158MP0002822_catalepsy0.63457218
159MP0001727_abnormal_embryo_implantation0.62875976
160MP0002933_joint_inflammation0.62141815
161MP0004036_abnormal_muscle_relaxation0.61686843
162MP0003075_altered_response_to0.61656079
163MP0004811_abnormal_neuron_physiology0.61083541
164MP0002970_abnormal_white_adipose0.61020301
165MP0000477_abnormal_intestine_morphology0.60365893
166MP0006072_abnormal_retinal_apoptosis0.57565754
167MP0001664_abnormal_digestion0.56992595
168MP0005388_respiratory_system_phenotype0.54875547
169MP0002133_abnormal_respiratory_system0.54875547
170MP0001764_abnormal_homeostasis0.54095618
171MP0005330_cardiomyopathy0.52473627
172MP0005023_abnormal_wound_healing0.52407768
173MP0003115_abnormal_respiratory_system0.50867917
174MP0002136_abnormal_kidney_physiology0.50202711
175MP0005464_abnormal_platelet_physiology0.47119676
176MP0000534_abnormal_ureter_morphology0.44514714
177MP0005084_abnormal_gallbladder_morpholo0.44205682

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)8.60821597
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.38288828
3Degeneration of the lateral corticospinal tracts (HP:0002314)6.38288828
4Neurofibrillary tangles (HP:0002185)5.98252019
5Prolonged partial thromboplastin time (HP:0003645)5.44400536
6Joint hemorrhage (HP:0005261)5.20656565
7Hemorrhage of the eye (HP:0011885)4.96985424
8Abnormality of the corticospinal tract (HP:0002492)4.72347734
9Complement deficiency (HP:0004431)4.65155006
10Hypobetalipoproteinemia (HP:0003563)4.44363639
11Parakeratosis (HP:0001036)4.41528108
12Cerebral inclusion bodies (HP:0100314)4.36975726
13Peripheral hypomyelination (HP:0007182)4.31271291
14Xanthomatosis (HP:0000991)4.26839666
15Sensory axonal neuropathy (HP:0003390)4.20924665
16Onion bulb formation (HP:0003383)4.03137135
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.02953461
18Systemic lupus erythematosus (HP:0002725)3.93503073
19Cerebral hypomyelination (HP:0006808)3.90145437
20Abnormality of the common coagulation pathway (HP:0010990)3.87020358
21Supranuclear gaze palsy (HP:0000605)3.82813999
22Flat acetabular roof (HP:0003180)3.80777235
23Abnormality of complement system (HP:0005339)3.73812033
24Abnormality of carpal bone ossification (HP:0006257)3.69408892
25Hypercholesterolemia (HP:0003124)3.66658284
26Glomerulonephritis (HP:0000099)3.64845365
27Abnormal auditory evoked potentials (HP:0006958)3.64299024
28Insidious onset (HP:0003587)3.40183264
29Termporal pattern (HP:0011008)3.40183264
30Myokymia (HP:0002411)3.32654062
31Hypolipoproteinemia (HP:0010981)3.29858626
32Spastic gait (HP:0002064)3.27482087
33Abnormal tarsal ossification (HP:0008369)3.10007903
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.09980926
35Menorrhagia (HP:0000132)3.06395734
36Spontaneous abortion (HP:0005268)3.03715771
37Segmental peripheral demyelination/remyelination (HP:0003481)3.03690685
38Leukodystrophy (HP:0002415)3.03606083
39Vascular calcification (HP:0004934)3.02082126
40Intention tremor (HP:0002080)2.97162788
41Abnormality of glycolysis (HP:0004366)2.96360967
42Increased serum pyruvate (HP:0003542)2.96360967
43Alacrima (HP:0000522)2.96264350
44Dysmetria (HP:0001310)2.95307350
45Abnormality of monocarboxylic acid metabolism (HP:0010996)2.86538974
46Congenital ichthyosiform erythroderma (HP:0007431)2.86321810
47Scanning speech (HP:0002168)2.84734480
48Abnormal ossification of hand bones (HP:0005921)2.77048703
49Cardiovascular calcification (HP:0011915)2.73382592
50Abnormal hand bone ossification (HP:0010660)2.73161217
51Acanthocytosis (HP:0001927)2.73008489
52Hypoplastic pelvis (HP:0008839)2.71227099
53Urinary glycosaminoglycan excretion (HP:0003541)2.70447845
54Mucopolysacchariduria (HP:0008155)2.70447845
55Retinal dysplasia (HP:0007973)2.68491659
56Small epiphyses (HP:0010585)2.67642456
57Protrusio acetabuli (HP:0003179)2.67146697
58Epidermoid cyst (HP:0200040)2.67084817
59Neonatal short-limb short stature (HP:0008921)2.66421916
60Absent septum pellucidum (HP:0001331)2.66229451
61Slow saccadic eye movements (HP:0000514)2.63777167
62Cerebral hemorrhage (HP:0001342)2.61681383
63Purpura (HP:0000979)2.61416927
64CNS hypomyelination (HP:0003429)2.58222312
65Axonal loss (HP:0003447)2.56261047
66Hydroxyprolinuria (HP:0003080)2.53593550
67Abnormality of proline metabolism (HP:0010907)2.53593550
68Hypoalphalipoproteinemia (HP:0003233)2.52080629
69Skin nodule (HP:0200036)2.51727461
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.51502554
71Abnormality of polysaccharide metabolism (HP:0011012)2.51502554
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.51502554
73Autoamputation (HP:0001218)2.51075183
74Asymmetry of the thorax (HP:0001555)2.50279968
75Intrahepatic cholestasis (HP:0001406)2.48894870
76Thickened helices (HP:0000391)2.47189416
77Ankle clonus (HP:0011448)2.46658990
78Akinesia (HP:0002304)2.42487892
79Fat malabsorption (HP:0002630)2.42124771
80Pheochromocytoma (HP:0002666)2.41836272
81Conjugated hyperbilirubinemia (HP:0002908)2.41387268
82Broad alveolar ridges (HP:0000187)2.39557466
83Increased circulating renin level (HP:0000848)2.36150340
84Decreased lacrimation (HP:0000633)2.35557457
85Gingival bleeding (HP:0000225)2.34454137
86Clumsiness (HP:0002312)2.34180147
87Focal motor seizures (HP:0011153)2.33540751
88Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.33154802
89Flared iliac wings (HP:0002869)2.30961279
90Abnormality of glutamine family amino acid metabolism (HP:0010902)2.30677276
91Broad palm (HP:0001169)2.30401728
92Premature skin wrinkling (HP:0100678)2.28503340
93Dysostosis multiplex (HP:0000943)2.28326930
94Muscle fiber splitting (HP:0003555)2.25896249
95Spastic paraparesis (HP:0002313)2.24458837
96Abnormality of the septum pellucidum (HP:0007375)2.24300106
97Morphological abnormality of the inner ear (HP:0011390)2.22648700
98Mitral stenosis (HP:0001718)2.21183129
99Poor speech (HP:0002465)2.21031017
100Hypoglycemic coma (HP:0001325)2.20621497
101Split foot (HP:0001839)2.20376125
102Abnormality of the lumbar spine (HP:0100712)2.20031449
103Pigmentary retinal degeneration (HP:0001146)2.19532110
104Epiphyseal dysplasia (HP:0002656)2.18691047
105Metabolic alkalosis (HP:0200114)2.18329875
106Foot dorsiflexor weakness (HP:0009027)2.17463629
107Stridor (HP:0010307)2.17233400
108Anteriorly placed anus (HP:0001545)2.15969958
109Abnormality of the acetabulum (HP:0003170)2.14601165
110Limb dystonia (HP:0002451)2.13963840
111Spastic tetraparesis (HP:0001285)2.13125305
112Vaginal fistula (HP:0004320)2.12881761
113Decreased motor nerve conduction velocity (HP:0003431)2.11789444
114Neuroendocrine neoplasm (HP:0100634)2.11585289
115Renal Fanconi syndrome (HP:0001994)2.10644069
116Epileptic encephalopathy (HP:0200134)2.10538571
117Nephritis (HP:0000123)2.09206288
118Neonatal death (HP:0003811)2.09180037
119Bronchomalacia (HP:0002780)2.07537088
120Hypophosphatemic rickets (HP:0004912)2.06605606
121Lower limb muscle weakness (HP:0007340)2.05365761
122Aplasia involving bones of the extremities (HP:0009825)2.04663896
123Aplasia involving bones of the upper limbs (HP:0009823)2.04663896
124Aplasia of the phalanges of the hand (HP:0009802)2.04663896
125Vaginal atresia (HP:0000148)2.03910532
126Methylmalonic acidemia (HP:0002912)2.03844903
127Hypomagnesemia (HP:0002917)2.02628944
128Infantile muscular hypotonia (HP:0008947)2.02606064
1293-Methylglutaconic aciduria (HP:0003535)1.99496457
130Patchy hypopigmentation of hair (HP:0011365)1.98479391
131Hyperactive renin-angiotensin system (HP:0000841)1.98070992
132Amyloidosis (HP:0011034)1.97886647
133Hepatosplenomegaly (HP:0001433)1.97237308
134White forelock (HP:0002211)1.96652278
135Irregular epiphyses (HP:0010582)1.96474254
136Ileus (HP:0002595)1.95290418
137Cerebral aneurysm (HP:0004944)1.94814807
138Abnormality of the foot musculature (HP:0001436)1.93761786
139Potter facies (HP:0002009)1.93421296
140Facial shape deformation (HP:0011334)1.93421296
141Action tremor (HP:0002345)1.93401720
142Genital tract atresia (HP:0001827)1.92411247
143Choreoathetosis (HP:0001266)1.92170296
144Cupped ribs (HP:0000887)1.91506490
145Prolonged neonatal jaundice (HP:0006579)1.90921578
146Widely patent fontanelles and sutures (HP:0004492)1.89490414
147Coxa vara (HP:0002812)1.88630704
148Hyperlipoproteinemia (HP:0010980)1.88591725
149Abnormality of the phalanges of the 2nd finger (HP:0009541)1.87835470
150Acute necrotizing encephalopathy (HP:0006965)1.87011643
151Megalencephaly (HP:0001355)1.86845459
152Septo-optic dysplasia (HP:0100842)1.86533983
153Late onset (HP:0003584)1.85609775
154Distal sensory impairment (HP:0002936)1.83796420
155Hypotension (HP:0002615)1.83592896
156Hypokalemic alkalosis (HP:0001949)1.83450915
157Hypoplasia of the iris (HP:0007676)1.83008494
158Progressive neurologic deterioration (HP:0002344)1.81950626
159Ovoid vertebral bodies (HP:0003300)1.81487681
160Peripheral demyelination (HP:0011096)1.80699011
161Paraparesis (HP:0002385)1.79153697
162Myocardial infarction (HP:0001658)1.77823177
163Vertebral compression fractures (HP:0002953)1.76302444
164Abnormality of the Achilles tendon (HP:0005109)1.75877389
165Hyporeflexia of lower limbs (HP:0002600)1.75461534
166Atonic seizures (HP:0010819)1.74694226
167Right ventricular cardiomyopathy (HP:0011663)1.74158366
168Abnormal delivery (HP:0001787)1.73947213
169Hammertoe (HP:0001765)1.72611547
170Humeroradial synostosis (HP:0003041)1.72313492
171Synostosis involving the elbow (HP:0003938)1.72313492
172Gowers sign (HP:0003391)1.71667661
173Postnatal microcephaly (HP:0005484)1.71431526
174Abnormal foot bone ossification (HP:0010675)1.70879308
175Generalized myoclonic seizures (HP:0002123)1.70441878
176Abnormality of aromatic amino acid family metabolism (HP:0004338)1.69941056
177Rickets (HP:0002748)1.69648395
178Morphological abnormality of the pyramidal tract (HP:0002062)1.69468043
179Abnormality of the intrinsic pathway (HP:0010989)1.69138005
180Limited elbow extension (HP:0001377)1.68538112
181Abnormality of the wing of the ilium (HP:0011867)1.68033361
182Neuronal loss in central nervous system (HP:0002529)1.67940822
183Impaired pain sensation (HP:0007328)1.67843651
184Abnormality of pain sensation (HP:0010832)1.67843651
185Erythroderma (HP:0001019)1.67237091
186Glomerulosclerosis (HP:0000096)1.64024120
187Neonatal onset (HP:0003623)1.63007596
188Enlarged kidneys (HP:0000105)1.62449109
189Abnormality of renin-angiotensin system (HP:0000847)1.60797113
190Pancreatic islet-cell hyperplasia (HP:0004510)1.60341376
191Thrombophlebitis (HP:0004418)1.60071258
192Hypertriglyceridemia (HP:0002155)1.58339475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.83450681
2FGFR45.05964714
3OXSR14.27451824
4RIPK13.90407521
5EPHA23.54383070
6FGFR33.39504077
7ERN12.92450309
8EPHB12.88897525
9PRPF4B2.88839047
10MAPKAPK52.84126949
11PKN12.79132979
12BCR2.73524478
13MST1R2.52425970
14TRIB32.48241641
15PBK2.38281695
16CDK192.34327157
17WNK42.23496901
18MET2.19183304
19DDR22.15815827
20CASK2.15161773
21LMTK22.12195850
22FGFR22.03579241
23MST41.98076485
24LIMK11.93487454
25CSNK1G31.91959392
26PDGFRA1.88678521
27PKN21.84411758
28CSNK1A1L1.79942670
29UHMK11.79209181
30WNK11.77497781
31PNCK1.76048736
32CAMK2B1.75932113
33SIK11.70380965
34SIK21.68277116
35NTRK11.65618437
36NEK61.62870838
37TESK21.59403102
38TNIK1.59269352
39EEF2K1.52671467
40CDK121.51443505
41CSNK1G11.45999782
42ROCK21.45754709
43CSNK1G21.44089486
44CAMK2D1.39055385
45EPHA41.39026189
46DYRK1B1.36354913
47FGR1.31409354
48SGK4941.25132218
49SGK2231.25132218
50PRKAA21.23975256
51MAPKAPK31.23860791
52MUSK1.19289915
53CLK11.17152516
54CAMK2G1.15967679
55RET1.15546345
56FGFR11.13516332
57CDC42BPA1.10024889
58EPHA31.09812281
59MAPK111.09330799
60MAP2K61.09033060
61PAK61.07464102
62MARK11.07178576
63DYRK21.00497633
64CAMK2A1.00419862
65PTK20.99233674
66TYRO30.97950905
67MAP3K20.93474249
68MAP3K10.86606748
69IRAK30.86493327
70BMPR1B0.83491011
71CDK140.83305062
72PHKG20.82569652
73PHKG10.82569652
74ICK0.81566218
75CDK50.80954038
76PTK60.77105971
77TRPM70.76485993
78PRKCE0.76359798
79ERBB20.75017736
80CDK150.74581878
81PRKAA10.74387062
82MAP3K70.72890179
83MARK20.72441474
84LATS20.72399723
85PRKG20.72243420
86PRKCQ0.72214308
87MAPK150.71450645
88CDK180.70687807
89MAP2K30.69674359
90TESK10.67436098
91AKT30.67160739
92CDK11A0.65241553
93PRKD10.65197320
94NEK90.63297907
95TAOK20.62107731
96MAP3K110.60695746
97PAK30.60253848
98PDPK10.60062193
99ARAF0.60027506
100NTRK30.59730772
101RPS6KA50.57774710
102MAP3K90.57611570
103MATK0.57449944
104FLT30.56459958
105ERBB40.56153446
106FER0.55805724
107NTRK20.55600241
108MAP3K30.53700392
109TGFBR20.52448766
110SGK10.52248078
111GRK70.52082018
112TAOK10.51827573
113PRKCH0.51760858
114PRKG10.50983118
115MAP3K130.49828182
116PRKACB0.49430297
117MAPK130.49340875
118SRC0.48432982
119SGK30.48032733
120PRKD20.47785186
121TYK20.47476182
122CSNK1D0.47356942
123FYN0.46763323
124SMG10.46439930
125NME10.45266167
126GRK50.44867174
127CSNK1A10.44853325
128STK380.44588003
129ADRBK20.43711067
130FES0.43160593
131MTOR0.42042748
132RPS6KB10.41834232
133DAPK30.41833389
134GRK10.41058185
135BMPR20.40361978
136STK110.40338613
137MAP2K20.38909286
138GSK3A0.38739397
139ITK0.38584805
140PRKACG0.38545455
141STK160.38388915
142PRKACA0.36139602
143PTK2B0.34965579
144PLK20.34882071
145MAP2K10.33978553
146MAPK70.33647775
147KSR20.32230978
148MAP2K70.32185033
149IRAK20.31832062
150DMPK0.30169496
151PAK10.29447042
152CSNK1E0.29362933
153RPS6KA20.29337443
154PRKCZ0.28565182
155MINK10.28479926
156INSR0.27068864
157PDK10.25453092
158MAP3K50.25355701
159OBSCN0.25352705
160PIK3CA0.25080848
161MAPK30.24900703
162BLK0.24842628
163LATS10.24476280
164DYRK1A0.24098506
165PRKCG0.23646204
166DAPK20.23094755

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.69934413
2Fatty acid elongation_Homo sapiens_hsa000624.53551357
3Steroid biosynthesis_Homo sapiens_hsa001004.23411180
4Complement and coagulation cascades_Homo sapiens_hsa046103.76706604
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.98907006
6Ether lipid metabolism_Homo sapiens_hsa005652.97502731
7Fat digestion and absorption_Homo sapiens_hsa049752.97321773
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95806366
9Other glycan degradation_Homo sapiens_hsa005112.75053981
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61268092
11Oxidative phosphorylation_Homo sapiens_hsa001902.60188864
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.59211067
13PPAR signaling pathway_Homo sapiens_hsa033202.53042112
14Vitamin B6 metabolism_Homo sapiens_hsa007502.37254782
15Arginine biosynthesis_Homo sapiens_hsa002202.29284070
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.27595064
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.26916768
18* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13300111
19Fatty acid degradation_Homo sapiens_hsa000712.01382014
20Histidine metabolism_Homo sapiens_hsa003402.00892021
21Sulfur metabolism_Homo sapiens_hsa009201.88121335
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.88012935
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.86604123
24Parkinsons disease_Homo sapiens_hsa050121.86015469
25Sphingolipid metabolism_Homo sapiens_hsa006001.85655913
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.85311842
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.81732519
28Fatty acid biosynthesis_Homo sapiens_hsa000611.79024134
29Protein export_Homo sapiens_hsa030601.78498391
30Alzheimers disease_Homo sapiens_hsa050101.72638774
31Bile secretion_Homo sapiens_hsa049761.65853540
32Linoleic acid metabolism_Homo sapiens_hsa005911.64800785
33Collecting duct acid secretion_Homo sapiens_hsa049661.55787921
34Fructose and mannose metabolism_Homo sapiens_hsa000511.53765106
35Phenylalanine metabolism_Homo sapiens_hsa003601.53749658
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53293348
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48599319
38Axon guidance_Homo sapiens_hsa043601.48191828
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.44498198
40Starch and sucrose metabolism_Homo sapiens_hsa005001.42003258
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41728016
42GABAergic synapse_Homo sapiens_hsa047271.41355143
43Serotonergic synapse_Homo sapiens_hsa047261.41129228
44Glutamatergic synapse_Homo sapiens_hsa047241.34629484
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32291775
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.23569576
47Vibrio cholerae infection_Homo sapiens_hsa051101.22579148
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20752684
49Arginine and proline metabolism_Homo sapiens_hsa003301.20571978
50Galactose metabolism_Homo sapiens_hsa000521.18391979
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18188539
52Renin-angiotensin system_Homo sapiens_hsa046141.17751759
53Morphine addiction_Homo sapiens_hsa050321.16606715
54Synaptic vesicle cycle_Homo sapiens_hsa047211.09512473
55Butanoate metabolism_Homo sapiens_hsa006501.08399392
56ABC transporters_Homo sapiens_hsa020101.08232717
57Phototransduction_Homo sapiens_hsa047441.07240101
58Staphylococcus aureus infection_Homo sapiens_hsa051501.07159518
59Cardiac muscle contraction_Homo sapiens_hsa042601.03486382
60Nicotine addiction_Homo sapiens_hsa050331.02809774
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98634710
62Arachidonic acid metabolism_Homo sapiens_hsa005900.98198255
63Glycerolipid metabolism_Homo sapiens_hsa005610.98062425
64Long-term depression_Homo sapiens_hsa047300.96753110
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96620767
66Cocaine addiction_Homo sapiens_hsa050300.94770380
67Rheumatoid arthritis_Homo sapiens_hsa053230.94558192
68Huntingtons disease_Homo sapiens_hsa050160.93636488
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.90570339
70Retinol metabolism_Homo sapiens_hsa008300.90312291
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89964956
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89246435
73N-Glycan biosynthesis_Homo sapiens_hsa005100.89141184
74Thyroid hormone synthesis_Homo sapiens_hsa049180.88128614
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87534205
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.84738704
77Circadian entrainment_Homo sapiens_hsa047130.84542948
78Renal cell carcinoma_Homo sapiens_hsa052110.84426606
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81583432
80Sulfur relay system_Homo sapiens_hsa041220.80979848
81Insulin resistance_Homo sapiens_hsa049310.80952976
82Salivary secretion_Homo sapiens_hsa049700.80213588
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78759957
84Nitrogen metabolism_Homo sapiens_hsa009100.75941694
85Lysosome_Homo sapiens_hsa041420.75530504
86Glucagon signaling pathway_Homo sapiens_hsa049220.75292447
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.75067066
88Autoimmune thyroid disease_Homo sapiens_hsa053200.73322750
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73162625
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72924814
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.71797367
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71021563
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.70501468
94Carbon metabolism_Homo sapiens_hsa012000.70346953
95Phagosome_Homo sapiens_hsa041450.69530558
96Tight junction_Homo sapiens_hsa045300.69394346
97Folate biosynthesis_Homo sapiens_hsa007900.69200876
98Dopaminergic synapse_Homo sapiens_hsa047280.68359352
99Glutathione metabolism_Homo sapiens_hsa004800.68050318
100Cholinergic synapse_Homo sapiens_hsa047250.67472356
101Taste transduction_Homo sapiens_hsa047420.66370137
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65194648
103Gastric acid secretion_Homo sapiens_hsa049710.64423542
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64296515
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.63857544
106Mineral absorption_Homo sapiens_hsa049780.61685328
107Biosynthesis of amino acids_Homo sapiens_hsa012300.61157668
108Tryptophan metabolism_Homo sapiens_hsa003800.60981069
109Ras signaling pathway_Homo sapiens_hsa040140.60620010
110Ovarian steroidogenesis_Homo sapiens_hsa049130.59970459
111AMPK signaling pathway_Homo sapiens_hsa041520.59389610
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.58750088
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57867294
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57416279
115Endocytosis_Homo sapiens_hsa041440.56199517
116Insulin signaling pathway_Homo sapiens_hsa049100.55886484
117Fatty acid metabolism_Homo sapiens_hsa012120.53770366
118Amphetamine addiction_Homo sapiens_hsa050310.53545380
119Renin secretion_Homo sapiens_hsa049240.51423657
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.51221656
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50049235
122Pancreatic secretion_Homo sapiens_hsa049720.48415208
123Metabolic pathways_Homo sapiens_hsa011000.47160264
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46816202
125Lysine degradation_Homo sapiens_hsa003100.46622257
126Pertussis_Homo sapiens_hsa051330.46396501
127Tyrosine metabolism_Homo sapiens_hsa003500.46380710
128Vitamin digestion and absorption_Homo sapiens_hsa049770.44911635
129Protein digestion and absorption_Homo sapiens_hsa049740.44053155
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43425648
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42649064
132Asthma_Homo sapiens_hsa053100.42361359
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42067531
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42039225
135Dorso-ventral axis formation_Homo sapiens_hsa043200.41724211
136ErbB signaling pathway_Homo sapiens_hsa040120.39013823
137Gap junction_Homo sapiens_hsa045400.38741032
138Propanoate metabolism_Homo sapiens_hsa006400.38361082
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38111780
140GnRH signaling pathway_Homo sapiens_hsa049120.36908080
141Insulin secretion_Homo sapiens_hsa049110.35628561
142ECM-receptor interaction_Homo sapiens_hsa045120.35272194
143Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34055647
144Calcium signaling pathway_Homo sapiens_hsa040200.33792035
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33326078
146Inositol phosphate metabolism_Homo sapiens_hsa005620.32850459
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32439113
148Olfactory transduction_Homo sapiens_hsa047400.31984638
149Prion diseases_Homo sapiens_hsa050200.31450282
150cAMP signaling pathway_Homo sapiens_hsa040240.30501129
151Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30396332
152Chemical carcinogenesis_Homo sapiens_hsa052040.30057330
153Peroxisome_Homo sapiens_hsa041460.29142739
154Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28896494
155Central carbon metabolism in cancer_Homo sapiens_hsa052300.28484321
156Regulation of autophagy_Homo sapiens_hsa041400.27917457
157Long-term potentiation_Homo sapiens_hsa047200.27737492
158Hedgehog signaling pathway_Homo sapiens_hsa043400.27551545
159Pyruvate metabolism_Homo sapiens_hsa006200.25697232
160beta-Alanine metabolism_Homo sapiens_hsa004100.24872523

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