

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 6.57550688 |
| 2 | DNA deamination (GO:0045006) | 6.06600168 |
| 3 | viral transcription (GO:0019083) | 5.66992186 |
| 4 | translational termination (GO:0006415) | 5.43475423 |
| 5 | ribosomal small subunit biogenesis (GO:0042274) | 5.14300135 |
| 6 | maturation of SSU-rRNA (GO:0030490) | 4.96302660 |
| 7 | translational elongation (GO:0006414) | 4.96128187 |
| 8 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.67602589 |
| 9 | cotranslational protein targeting to membrane (GO:0006613) | 4.54928974 |
| 10 | protein targeting to ER (GO:0045047) | 4.53043424 |
| 11 | establishment of viral latency (GO:0019043) | 4.46488491 |
| 12 | translational initiation (GO:0006413) | 4.32471513 |
| 13 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.31885856 |
| 14 | protein localization to endoplasmic reticulum (GO:0070972) | 4.29631314 |
| 15 | viral life cycle (GO:0019058) | 4.29615891 |
| 16 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.24815139 |
| 17 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.24665962 |
| 18 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.22879813 |
| 19 | cellular protein complex disassembly (GO:0043624) | 4.21561651 |
| 20 | ribosomal large subunit biogenesis (GO:0042273) | 4.13053830 |
| 21 | DNA strand elongation (GO:0022616) | 4.07026894 |
| 22 | formation of translation preinitiation complex (GO:0001731) | 4.06700171 |
| 23 | protein maturation by protein folding (GO:0022417) | 3.89213418 |
| 24 | protein complex disassembly (GO:0043241) | 3.77030760 |
| 25 | telomere maintenance via recombination (GO:0000722) | 3.76501107 |
| 26 | proteasome assembly (GO:0043248) | 3.71480337 |
| 27 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.60514378 |
| 28 | translation (GO:0006412) | 3.59340688 |
| 29 | macromolecular complex disassembly (GO:0032984) | 3.54776036 |
| 30 | regulation of mitochondrial translation (GO:0070129) | 3.53852818 |
| 31 | polyketide metabolic process (GO:0030638) | 3.40708109 |
| 32 | doxorubicin metabolic process (GO:0044598) | 3.40708109 |
| 33 | daunorubicin metabolic process (GO:0044597) | 3.40708109 |
| 34 | mitotic recombination (GO:0006312) | 3.39195653 |
| 35 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.37518132 |
| 36 | DNA replication initiation (GO:0006270) | 3.34193501 |
| 37 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.25362292 |
| 38 | nucleobase biosynthetic process (GO:0046112) | 3.23211177 |
| 39 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.22592924 |
| 40 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.22566632 |
| 41 | DNA ligation (GO:0006266) | 3.20392046 |
| 42 | telomere maintenance via telomere lengthening (GO:0010833) | 3.19723322 |
| 43 | proline biosynthetic process (GO:0006561) | 3.17733358 |
| 44 | protein targeting to mitochondrion (GO:0006626) | 3.17229707 |
| 45 | purine nucleobase biosynthetic process (GO:0009113) | 3.16964131 |
| 46 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.15492396 |
| 47 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.14433763 |
| 48 | chaperone-mediated protein transport (GO:0072321) | 3.09452907 |
| 49 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.09383941 |
| 50 | oxidative phosphorylation (GO:0006119) | 3.07768295 |
| 51 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.07286276 |
| 52 | base-excision repair (GO:0006284) | 3.07165159 |
| 53 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.05924804 |
| 54 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.05924804 |
| 55 | mRNA catabolic process (GO:0006402) | 3.05385728 |
| 56 | cellular component biogenesis (GO:0044085) | 3.05258638 |
| 57 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.05158516 |
| 58 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.04837758 |
| 59 | rRNA processing (GO:0006364) | 3.02652626 |
| 60 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.01203611 |
| 61 | IMP biosynthetic process (GO:0006188) | 2.99241934 |
| 62 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.98692277 |
| 63 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.98379404 |
| 64 | termination of RNA polymerase III transcription (GO:0006386) | 2.98379404 |
| 65 | GDP-mannose metabolic process (GO:0019673) | 2.97593372 |
| 66 | negative regulation of ligase activity (GO:0051352) | 2.97526139 |
| 67 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.97526139 |
| 68 | COPI coating of Golgi vesicle (GO:0048205) | 2.97017271 |
| 69 | Golgi transport vesicle coating (GO:0048200) | 2.97017271 |
| 70 | RNA catabolic process (GO:0006401) | 2.97000371 |
| 71 | CENP-A containing nucleosome assembly (GO:0034080) | 2.95741499 |
| 72 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.94586137 |
| 73 | chromatin remodeling at centromere (GO:0031055) | 2.92733836 |
| 74 | L-serine metabolic process (GO:0006563) | 2.92707317 |
| 75 | rRNA metabolic process (GO:0016072) | 2.91149135 |
| 76 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.90912663 |
| 77 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.90124925 |
| 78 | establishment of protein localization to mitochondrion (GO:0072655) | 2.90023092 |
| 79 | pseudouridine synthesis (GO:0001522) | 2.89192517 |
| 80 | ribosome biogenesis (GO:0042254) | 2.89050308 |
| 81 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.88896096 |
| 82 | DNA replication checkpoint (GO:0000076) | 2.88399538 |
| 83 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.87635327 |
| 84 | ATP synthesis coupled proton transport (GO:0015986) | 2.87635327 |
| 85 | protein targeting to membrane (GO:0006612) | 2.87472251 |
| 86 | deoxyribonucleotide catabolic process (GO:0009264) | 2.86957183 |
| 87 | DNA unwinding involved in DNA replication (GO:0006268) | 2.86780449 |
| 88 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.84456804 |
| 89 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.84001220 |
| 90 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.84001220 |
| 91 | deoxyribose phosphate catabolic process (GO:0046386) | 2.82726934 |
| 92 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.81270601 |
| 93 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.81185996 |
| 94 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.81185996 |
| 95 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.81185996 |
| 96 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.80727806 |
| 97 | histone arginine methylation (GO:0034969) | 2.80557328 |
| 98 | metallo-sulfur cluster assembly (GO:0031163) | 2.80196417 |
| 99 | iron-sulfur cluster assembly (GO:0016226) | 2.80196417 |
| 100 | regulation of ligase activity (GO:0051340) | 2.79301786 |
| 101 | protein localization to chromosome, centromeric region (GO:0071459) | 2.79081453 |
| 102 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.78110498 |
| 103 | protein localization to kinetochore (GO:0034501) | 2.77230567 |
| 104 | spliceosomal snRNP assembly (GO:0000387) | 2.75475228 |
| 105 | non-recombinational repair (GO:0000726) | 2.74494988 |
| 106 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.74494988 |
| 107 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.74066169 |
| 108 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.74066169 |
| 109 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.73870482 |
| 110 | tRNA aminoacylation for protein translation (GO:0006418) | 2.73737553 |
| 111 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.73675308 |
| 112 | 7-methylguanosine mRNA capping (GO:0006370) | 2.71906547 |
| 113 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.71493651 |
| 114 | regulation of translational fidelity (GO:0006450) | 2.71281526 |
| 115 | mitotic nuclear envelope reassembly (GO:0007084) | 2.71191569 |
| 116 | nuclear envelope reassembly (GO:0031468) | 2.71191569 |
| 117 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.70512124 |
| 118 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.69867530 |
| 119 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.68724526 |
| 120 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.68724526 |
| 121 | rRNA modification (GO:0000154) | 2.67567421 |
| 122 | kinetochore organization (GO:0051383) | 2.65809687 |
| 123 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.65388035 |
| 124 | CTP metabolic process (GO:0046036) | 2.65186821 |
| 125 | CTP biosynthetic process (GO:0006241) | 2.65186821 |
| 126 | establishment of integrated proviral latency (GO:0075713) | 2.64392771 |
| 127 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.62897178 |
| 128 | kinetochore assembly (GO:0051382) | 2.62865108 |
| 129 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.62308738 |
| 130 | pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130) | 2.61388992 |
| 131 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.59183290 |
| 132 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.58368740 |
| 133 | DNA replication-independent nucleosome organization (GO:0034724) | 2.58368740 |
| 134 | viral mRNA export from host cell nucleus (GO:0046784) | 2.57741558 |
| 135 | GTP biosynthetic process (GO:0006183) | 2.56452248 |
| 136 | positive regulation of ligase activity (GO:0051351) | 2.54878807 |
| 137 | protein deneddylation (GO:0000338) | 2.53771174 |
| 138 | nucleoside salvage (GO:0043174) | 2.53760909 |
| 139 | pyrimidine nucleoside biosynthetic process (GO:0046134) | 2.52236209 |
| 140 | cullin deneddylation (GO:0010388) | 2.51199857 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.87042797 |
| 2 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.09701153 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.03276513 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.14862292 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.06970841 |
| 6 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.93924848 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.91011560 |
| 8 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.89624000 |
| 9 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.80187723 |
| 10 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.78368332 |
| 11 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.76869549 |
| 12 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.75300388 |
| 13 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.74368682 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.69505956 |
| 15 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.67964612 |
| 16 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.66850399 |
| 17 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.52449916 |
| 18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.50762594 |
| 19 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.48856938 |
| 20 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.46598014 |
| 21 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.29585134 |
| 22 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.11652592 |
| 23 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.07422008 |
| 24 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.98933610 |
| 25 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.97119902 |
| 26 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 1.96497423 |
| 27 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.90112029 |
| 28 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.89101327 |
| 29 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.87705012 |
| 30 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.86030643 |
| 31 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.85437823 |
| 32 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.80162911 |
| 33 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.78750712 |
| 34 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.72952946 |
| 35 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.71926420 |
| 36 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.70561625 |
| 37 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.65048600 |
| 38 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.63246553 |
| 39 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.61097261 |
| 40 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.60246977 |
| 41 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.59964221 |
| 42 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.56174475 |
| 43 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.53771600 |
| 44 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.51816930 |
| 45 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.49106980 |
| 46 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.48751987 |
| 47 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.47232636 |
| 48 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.41223625 |
| 49 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.41050645 |
| 50 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.40500677 |
| 51 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.39671869 |
| 52 | MYC_22102868_ChIP-Seq_BL_Human | 1.38662812 |
| 53 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.38219663 |
| 54 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.38160457 |
| 55 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.38127840 |
| 56 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.37371177 |
| 57 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37069039 |
| 58 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.34632450 |
| 59 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.33567475 |
| 60 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.32944167 |
| 61 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.31852575 |
| 62 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.27635140 |
| 63 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.27102548 |
| 64 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.26328553 |
| 65 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.26298719 |
| 66 | * STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.26254895 |
| 67 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.25286895 |
| 68 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.23177867 |
| 69 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.20880706 |
| 70 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.20633869 |
| 71 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.19502822 |
| 72 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.18358179 |
| 73 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.17351396 |
| 74 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.12066972 |
| 75 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.11848289 |
| 76 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.10750333 |
| 77 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.10115367 |
| 78 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.09979515 |
| 79 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.08454067 |
| 80 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.07984039 |
| 81 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.07753601 |
| 82 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.07182733 |
| 83 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.06496442 |
| 84 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.05710679 |
| 85 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.05390932 |
| 86 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.03380883 |
| 87 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.02581106 |
| 88 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.02499432 |
| 89 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.02122202 |
| 90 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.01628017 |
| 91 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.00765356 |
| 92 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.99491096 |
| 93 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.99448507 |
| 94 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.98793823 |
| 95 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.98523089 |
| 96 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.98080644 |
| 97 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.97380340 |
| 98 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.97189410 |
| 99 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.96013797 |
| 100 | P68_20966046_ChIP-Seq_HELA_Human | 0.95805284 |
| 101 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.95780225 |
| 102 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.95571930 |
| 103 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.95523330 |
| 104 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.95305791 |
| 105 | UTX_26944678_Chip-Seq_JUKART_Human | 0.94388156 |
| 106 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.94312543 |
| 107 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.93919625 |
| 108 | MAF_26560356_Chip-Seq_TH2_Human | 0.93890099 |
| 109 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.92035882 |
| 110 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.91795951 |
| 111 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.91279075 |
| 112 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.90647850 |
| 113 | MAF_26560356_Chip-Seq_TH1_Human | 0.90373001 |
| 114 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.89914845 |
| 115 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.89496591 |
| 116 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.89409633 |
| 117 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.88558044 |
| 118 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.88167091 |
| 119 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.87683345 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.32379424 |
| 2 | MP0002139_abnormal_hepatobiliary_system | 3.04727268 |
| 3 | MP0003111_abnormal_nucleus_morphology | 3.04220684 |
| 4 | MP0010094_abnormal_chromosome_stability | 2.99598514 |
| 5 | MP0003806_abnormal_nucleotide_metabolis | 2.95755509 |
| 6 | MP0009379_abnormal_foot_pigmentation | 2.93153285 |
| 7 | MP0004957_abnormal_blastocyst_morpholog | 2.91507729 |
| 8 | MP0003077_abnormal_cell_cycle | 2.87992720 |
| 9 | MP0002396_abnormal_hematopoietic_system | 2.47582464 |
| 10 | MP0003186_abnormal_redox_activity | 2.31818546 |
| 11 | MP0008058_abnormal_DNA_repair | 2.25028015 |
| 12 | MP0008057_abnormal_DNA_replication | 2.16029569 |
| 13 | MP0008007_abnormal_cellular_replicative | 2.09649018 |
| 14 | MP0005058_abnormal_lysosome_morphology | 1.99915992 |
| 15 | MP0005360_urolithiasis | 1.91179048 |
| 16 | MP0005410_abnormal_fertilization | 1.87002325 |
| 17 | MP0005365_abnormal_bile_salt | 1.86838276 |
| 18 | MP0006036_abnormal_mitochondrial_physio | 1.86186313 |
| 19 | MP0003303_peritoneal_inflammation | 1.81904875 |
| 20 | MP0000685_abnormal_immune_system | 1.77430797 |
| 21 | MP0002132_abnormal_respiratory_system | 1.76831553 |
| 22 | MP0000566_synostosis | 1.76822007 |
| 23 | MP0008260_abnormal_autophagy | 1.73563335 |
| 24 | MP0003191_abnormal_cellular_cholesterol | 1.71462790 |
| 25 | MP0000490_abnormal_crypts_of | 1.70381775 |
| 26 | MP0005451_abnormal_body_composition | 1.68377794 |
| 27 | MP0008932_abnormal_embryonic_tissue | 1.67172278 |
| 28 | MP0005397_hematopoietic_system_phenotyp | 1.66563227 |
| 29 | MP0001545_abnormal_hematopoietic_system | 1.66563227 |
| 30 | MP0005085_abnormal_gallbladder_physiolo | 1.65047990 |
| 31 | MP0004808_abnormal_hematopoietic_stem | 1.63393907 |
| 32 | MP0001853_heart_inflammation | 1.62003025 |
| 33 | MP0009785_altered_susceptibility_to | 1.60300555 |
| 34 | MP0001835_abnormal_antigen_presentation | 1.58667251 |
| 35 | MP0003786_premature_aging | 1.57208006 |
| 36 | MP0001764_abnormal_homeostasis | 1.56368942 |
| 37 | MP0004147_increased_porphyrin_level | 1.53869202 |
| 38 | MP0009840_abnormal_foam_cell | 1.46828913 |
| 39 | MP0003656_abnormal_erythrocyte_physiolo | 1.46811319 |
| 40 | MP0005501_abnormal_skin_physiology | 1.41397867 |
| 41 | MP0009333_abnormal_splenocyte_physiolog | 1.37776081 |
| 42 | MP0005083_abnormal_biliary_tract | 1.37059289 |
| 43 | MP0000689_abnormal_spleen_morphology | 1.36029147 |
| 44 | MP0002163_abnormal_gland_morphology | 1.32935506 |
| 45 | MP0002398_abnormal_bone_marrow | 1.32815103 |
| 46 | MP0005025_abnormal_response_to | 1.30935320 |
| 47 | MP0002722_abnormal_immune_system | 1.30437474 |
| 48 | MP0009672_abnormal_birth_weight | 1.30218073 |
| 49 | MP0005075_abnormal_melanosome_morpholog | 1.29671618 |
| 50 | MP0002019_abnormal_tumor_incidence | 1.28045536 |
| 51 | MP0000858_altered_metastatic_potential | 1.27981284 |
| 52 | MP0000313_abnormal_cell_death | 1.25187861 |
| 53 | MP0003436_decreased_susceptibility_to | 1.22137163 |
| 54 | MP0006082_CNS_inflammation | 1.21119907 |
| 55 | MP0005319_abnormal_enzyme/_coenzyme | 1.21057865 |
| 56 | MP0003763_abnormal_thymus_physiology | 1.19915693 |
| 57 | MP0008875_abnormal_xenobiotic_pharmacok | 1.19069375 |
| 58 | MP0002429_abnormal_blood_cell | 1.16593425 |
| 59 | MP0006035_abnormal_mitochondrial_morpho | 1.15007344 |
| 60 | MP0001800_abnormal_humoral_immune | 1.14188417 |
| 61 | MP0001730_embryonic_growth_arrest | 1.13369975 |
| 62 | MP0001929_abnormal_gametogenesis | 1.10378543 |
| 63 | MP0003646_muscle_fatigue | 1.10238144 |
| 64 | MP0006292_abnormal_olfactory_placode | 1.08965373 |
| 65 | MP0005464_abnormal_platelet_physiology | 1.08718697 |
| 66 | MP0005174_abnormal_tail_pigmentation | 1.06247201 |
| 67 | MP0002210_abnormal_sex_determination | 1.05951169 |
| 68 | MP0008469_abnormal_protein_level | 1.05794529 |
| 69 | MP0002148_abnormal_hypersensitivity_rea | 1.04788049 |
| 70 | MP0000703_abnormal_thymus_morphology | 1.03963181 |
| 71 | MP0000716_abnormal_immune_system | 1.02688633 |
| 72 | MP0010030_abnormal_orbit_morphology | 1.02390429 |
| 73 | MP0000358_abnormal_cell_content/ | 1.02246777 |
| 74 | MP0002653_abnormal_ependyma_morphology | 1.02191588 |
| 75 | MP0005000_abnormal_immune_tolerance | 1.01827066 |
| 76 | MP0004185_abnormal_adipocyte_glucose | 1.01311671 |
| 77 | MP0000350_abnormal_cell_proliferation | 1.01237037 |
| 78 | MP0002452_abnormal_antigen_presenting | 0.99273421 |
| 79 | MP0002723_abnormal_immune_serum | 0.97663782 |
| 80 | MP0000598_abnormal_liver_morphology | 0.97189379 |
| 81 | MP0003315_abnormal_perineum_morphology | 0.97013250 |
| 82 | MP0002420_abnormal_adaptive_immunity | 0.96839999 |
| 83 | MP0005332_abnormal_amino_acid | 0.96729319 |
| 84 | MP0001819_abnormal_immune_cell | 0.96102476 |
| 85 | MP0003718_maternal_effect | 0.92021966 |
| 86 | MP0008877_abnormal_DNA_methylation | 0.91673629 |
| 87 | MP0002080_prenatal_lethality | 0.91263198 |
| 88 | MP0009763_increased_sensitivity_to | 0.90325056 |
| 89 | MP0005636_abnormal_mineral_homeostasis | 0.89539014 |
| 90 | MP0000609_abnormal_liver_physiology | 0.89527799 |
| 91 | MP0003123_paternal_imprinting | 0.89123132 |
| 92 | MP0010329_abnormal_lipoprotein_level | 0.87242352 |
| 93 | MP0005384_cellular_phenotype | 0.85918408 |
| 94 | MP0001145_abnormal_male_reproductive | 0.85716416 |
| 95 | MP0002160_abnormal_reproductive_system | 0.84536106 |
| 96 | MP0003011_delayed_dark_adaptation | 0.83706869 |
| 97 | MP0003567_abnormal_fetal_cardiomyocyte | 0.83138669 |
| 98 | MP0001661_extended_life_span | 0.81744243 |
| 99 | MP0005330_cardiomyopathy | 0.81652907 |
| 100 | MP0009697_abnormal_copulation | 0.81592166 |
| 101 | MP0002405_respiratory_system_inflammati | 0.80031415 |
| 102 | MP0003724_increased_susceptibility_to | 0.79994204 |
| 103 | MP0001697_abnormal_embryo_size | 0.78856752 |
| 104 | MP0003698_abnormal_male_reproductive | 0.77676302 |
| 105 | MP0002419_abnormal_innate_immunity | 0.76589876 |
| 106 | MP0001293_anophthalmia | 0.76551891 |
| 107 | MP0000343_altered_response_to | 0.75068533 |
| 108 | MP0003075_altered_response_to | 0.74914501 |
| 109 | MP0002095_abnormal_skin_pigmentation | 0.74382658 |
| 110 | MP0008995_early_reproductive_senescence | 0.72226189 |
| 111 | MP0000372_irregular_coat_pigmentation | 0.72156510 |
| 112 | MP0000653_abnormal_sex_gland | 0.72057098 |
| 113 | MP0001845_abnormal_inflammatory_respons | 0.71970997 |
| 114 | MP0009278_abnormal_bone_marrow | 0.71747721 |
| 115 | MP0000465_gastrointestinal_hemorrhage | 0.71488219 |
| 116 | MP0003984_embryonic_growth_retardation | 0.71308511 |
| 117 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.71272289 |
| 118 | MP0000467_abnormal_esophagus_morphology | 0.70953724 |
| 119 | MP0005389_reproductive_system_phenotype | 0.69929421 |
| 120 | MP0005671_abnormal_response_to | 0.69571214 |
| 121 | MP0001119_abnormal_female_reproductive | 0.69459445 |
| 122 | MP0001672_abnormal_embryogenesis/_devel | 0.69088891 |
| 123 | MP0005380_embryogenesis_phenotype | 0.69088891 |
| 124 | MP0001663_abnormal_digestive_system | 0.68962946 |
| 125 | MP0002085_abnormal_embryonic_tissue | 0.67964425 |
| 126 | MP0001727_abnormal_embryo_implantation | 0.65449900 |
| 127 | MP0001881_abnormal_mammary_gland | 0.65118450 |
| 128 | MP0005387_immune_system_phenotype | 0.63594018 |
| 129 | MP0001790_abnormal_immune_system | 0.63594018 |
| 130 | MP0005165_increased_susceptibility_to | 0.63592740 |
| 131 | MP0010155_abnormal_intestine_physiology | 0.63281196 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.92825493 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.62731619 |
| 3 | Reticulocytopenia (HP:0001896) | 5.28848678 |
| 4 | Cholecystitis (HP:0001082) | 3.94500068 |
| 5 | Abnormal gallbladder physiology (HP:0012438) | 3.94500068 |
| 6 | Macrocytic anemia (HP:0001972) | 3.60038405 |
| 7 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.47221985 |
| 8 | Pallor (HP:0000980) | 3.43516435 |
| 9 | Abnormality of glycolysis (HP:0004366) | 3.40410107 |
| 10 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.34785779 |
| 11 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.34785779 |
| 12 | Increased serum pyruvate (HP:0003542) | 3.34053529 |
| 13 | Thrombocytosis (HP:0001894) | 3.24670821 |
| 14 | 3-Methylglutaconic aciduria (HP:0003535) | 3.18812323 |
| 15 | Aplastic anemia (HP:0001915) | 3.17632021 |
| 16 | Hepatic necrosis (HP:0002605) | 3.12261447 |
| 17 | Reduced antithrombin III activity (HP:0001976) | 3.07435952 |
| 18 | Hepatocellular necrosis (HP:0001404) | 3.06623044 |
| 19 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.05248220 |
| 20 | Microretrognathia (HP:0000308) | 3.00880999 |
| 21 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.95873175 |
| 22 | Carpal bone hypoplasia (HP:0001498) | 2.88490593 |
| 23 | Microvesicular hepatic steatosis (HP:0001414) | 2.81993842 |
| 24 | Mitochondrial inheritance (HP:0001427) | 2.81287393 |
| 25 | Acute necrotizing encephalopathy (HP:0006965) | 2.79553522 |
| 26 | Type I transferrin isoform profile (HP:0003642) | 2.78291191 |
| 27 | Hepatosplenomegaly (HP:0001433) | 2.72285355 |
| 28 | Oral leukoplakia (HP:0002745) | 2.67433181 |
| 29 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.66836072 |
| 30 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.65586323 |
| 31 | Increased serum lactate (HP:0002151) | 2.64321668 |
| 32 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.64103499 |
| 33 | Increased CSF lactate (HP:0002490) | 2.61242867 |
| 34 | Acute encephalopathy (HP:0006846) | 2.54811490 |
| 35 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.54545365 |
| 36 | Lipid accumulation in hepatocytes (HP:0006561) | 2.51565426 |
| 37 | Abnormality of reticulocytes (HP:0004312) | 2.49854629 |
| 38 | Exertional dyspnea (HP:0002875) | 2.48247859 |
| 39 | Cerebral edema (HP:0002181) | 2.48147260 |
| 40 | Increased hepatocellular lipid droplets (HP:0006565) | 2.44167784 |
| 41 | Agammaglobulinemia (HP:0004432) | 2.43515885 |
| 42 | Multiple enchondromatosis (HP:0005701) | 2.42163445 |
| 43 | Hypertensive crisis (HP:0100735) | 2.38340853 |
| 44 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 2.36488327 |
| 45 | Nasal polyposis (HP:0100582) | 2.35571440 |
| 46 | Pancytopenia (HP:0001876) | 2.31354518 |
| 47 | Lactic acidosis (HP:0003128) | 2.26649962 |
| 48 | Absent thumb (HP:0009777) | 2.26298865 |
| 49 | Abnormal trabecular bone morphology (HP:0100671) | 2.25704361 |
| 50 | Exercise intolerance (HP:0003546) | 2.24041798 |
| 51 | Muscle fiber atrophy (HP:0100295) | 2.23692587 |
| 52 | Testicular atrophy (HP:0000029) | 2.23489101 |
| 53 | Ureteral duplication (HP:0000073) | 2.23087887 |
| 54 | Duplicated collecting system (HP:0000081) | 2.20188706 |
| 55 | 11 pairs of ribs (HP:0000878) | 2.19546972 |
| 56 | Petechiae (HP:0000967) | 2.16101332 |
| 57 | Poor head control (HP:0002421) | 2.14294516 |
| 58 | Nausea (HP:0002018) | 2.13945980 |
| 59 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.12319686 |
| 60 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.11860757 |
| 61 | Dicarboxylic aciduria (HP:0003215) | 2.11860757 |
| 62 | Type 2 muscle fiber atrophy (HP:0003554) | 2.10361087 |
| 63 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.09964432 |
| 64 | Rhabdomyolysis (HP:0003201) | 2.09623819 |
| 65 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.09501791 |
| 66 | Increased intramyocellular lipid droplets (HP:0012240) | 2.08972253 |
| 67 | Increased muscle lipid content (HP:0009058) | 2.07995558 |
| 68 | Abnormality of the nasal mucosa (HP:0000433) | 2.07186767 |
| 69 | Hypoplastic pelvis (HP:0008839) | 2.06375477 |
| 70 | Cholelithiasis (HP:0001081) | 2.04602884 |
| 71 | Emotional lability (HP:0000712) | 2.03395467 |
| 72 | Colon cancer (HP:0003003) | 2.02505758 |
| 73 | Opisthotonus (HP:0002179) | 2.02480147 |
| 74 | Seborrheic dermatitis (HP:0001051) | 2.00248552 |
| 75 | Myoglobinuria (HP:0002913) | 1.99890561 |
| 76 | Purpura (HP:0000979) | 1.99844101 |
| 77 | Progressive muscle weakness (HP:0003323) | 1.99391877 |
| 78 | Hypobetalipoproteinemia (HP:0003563) | 1.98999952 |
| 79 | Entropion (HP:0000621) | 1.98818807 |
| 80 | Obstructive lung disease (HP:0006536) | 1.98019642 |
| 81 | Chronic obstructive pulmonary disease (HP:0006510) | 1.98019642 |
| 82 | Ragged-red muscle fibers (HP:0003200) | 1.97769705 |
| 83 | Progressive macrocephaly (HP:0004481) | 1.96685822 |
| 84 | Degeneration of anterior horn cells (HP:0002398) | 1.94810962 |
| 85 | Abnormality of the anterior horn cell (HP:0006802) | 1.94810962 |
| 86 | Selective tooth agenesis (HP:0001592) | 1.94368220 |
| 87 | Long foot (HP:0001833) | 1.94042677 |
| 88 | Increased serum ferritin (HP:0003281) | 1.92838509 |
| 89 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.92094382 |
| 90 | Respiratory difficulties (HP:0002880) | 1.91570378 |
| 91 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.89795275 |
| 92 | Rough bone trabeculation (HP:0100670) | 1.89675156 |
| 93 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.89343468 |
| 94 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.89343468 |
| 95 | Abnormal protein glycosylation (HP:0012346) | 1.89343468 |
| 96 | Abnormal glycosylation (HP:0012345) | 1.89343468 |
| 97 | Hyperammonemia (HP:0001987) | 1.88860587 |
| 98 | Myositis (HP:0100614) | 1.88823703 |
| 99 | Brushfield spots (HP:0001088) | 1.88056838 |
| 100 | Chromsome breakage (HP:0040012) | 1.87793599 |
| 101 | Cleft eyelid (HP:0000625) | 1.87595900 |
| 102 | Lethargy (HP:0001254) | 1.86967506 |
| 103 | Birth length less than 3rd percentile (HP:0003561) | 1.86712378 |
| 104 | Cerebral palsy (HP:0100021) | 1.86603025 |
| 105 | Chronic otitis media (HP:0000389) | 1.86186042 |
| 106 | Myelodysplasia (HP:0002863) | 1.85663497 |
| 107 | Progressive microcephaly (HP:0000253) | 1.84904048 |
| 108 | Methylmalonic aciduria (HP:0012120) | 1.84657998 |
| 109 | Recurrent bronchitis (HP:0002837) | 1.82836958 |
| 110 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.82817537 |
| 111 | Leukodystrophy (HP:0002415) | 1.82531823 |
| 112 | Generalized aminoaciduria (HP:0002909) | 1.82528166 |
| 113 | Diastasis recti (HP:0001540) | 1.82367695 |
| 114 | Hyperglycinemia (HP:0002154) | 1.82245314 |
| 115 | Abnormality of the renal collecting system (HP:0004742) | 1.81508888 |
| 116 | Trismus (HP:0000211) | 1.81318410 |
| 117 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 1.79864109 |
| 118 | Abnormality of T cell physiology (HP:0011840) | 1.79767754 |
| 119 | Meckel diverticulum (HP:0002245) | 1.79208614 |
| 120 | Hyperbilirubinemia (HP:0002904) | 1.78778153 |
| 121 | Abnormality of the preputium (HP:0100587) | 1.78412021 |
| 122 | Bone marrow hypocellularity (HP:0005528) | 1.77440628 |
| 123 | Panhypogammaglobulinemia (HP:0003139) | 1.76936053 |
| 124 | Abnormality of the ileum (HP:0001549) | 1.76659371 |
| 125 | IgM deficiency (HP:0002850) | 1.76487252 |
| 126 | Increased IgM level (HP:0003496) | 1.74567365 |
| 127 | Secondary amenorrhea (HP:0000869) | 1.74431276 |
| 128 | Reticulocytosis (HP:0001923) | 1.74254709 |
| 129 | Renal Fanconi syndrome (HP:0001994) | 1.73353344 |
| 130 | CNS demyelination (HP:0007305) | 1.72974672 |
| 131 | Acute hepatic failure (HP:0006554) | 1.70345110 |
| 132 | Premature ovarian failure (HP:0008209) | 1.70299924 |
| 133 | Poikiloderma (HP:0001029) | 1.70112414 |
| 134 | Progressive external ophthalmoplegia (HP:0000590) | 1.69923183 |
| 135 | Abnormal spermatogenesis (HP:0008669) | 1.68988715 |
| 136 | Respiratory failure (HP:0002878) | 1.68408781 |
| 137 | Abnormality of serum amino acid levels (HP:0003112) | 1.68393298 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.00677844 |
| 2 | NME2 | 4.19355535 |
| 3 | BUB1 | 3.93892634 |
| 4 | WEE1 | 3.39445828 |
| 5 | EIF2AK1 | 3.34914901 |
| 6 | STK16 | 3.09184571 |
| 7 | MKNK2 | 3.00168597 |
| 8 | BCKDK | 2.79564265 |
| 9 | TAOK2 | 2.76944964 |
| 10 | CDK19 | 2.34764864 |
| 11 | TLK1 | 2.27091223 |
| 12 | MAP2K3 | 2.26245012 |
| 13 | MAP4K1 | 2.11148581 |
| 14 | SRPK1 | 1.96361034 |
| 15 | PBK | 1.91405824 |
| 16 | SMG1 | 1.88466662 |
| 17 | NEK2 | 1.81070892 |
| 18 | VRK1 | 1.80792068 |
| 19 | PIM2 | 1.78326977 |
| 20 | BRSK2 | 1.74153147 |
| 21 | CDC7 | 1.70619399 |
| 22 | TAOK1 | 1.67183711 |
| 23 | EIF2AK3 | 1.62835380 |
| 24 | TESK1 | 1.57238130 |
| 25 | KDR | 1.56687912 |
| 26 | PASK | 1.55460979 |
| 27 | PDK3 | 1.52929403 |
| 28 | PDK4 | 1.52929403 |
| 29 | MAP3K10 | 1.49389328 |
| 30 | CCNB1 | 1.47155786 |
| 31 | BLK | 1.46052681 |
| 32 | TESK2 | 1.36838672 |
| 33 | DYRK3 | 1.35752364 |
| 34 | FLT3 | 1.32741009 |
| 35 | MAP2K6 | 1.32075874 |
| 36 | MAP3K11 | 1.31846766 |
| 37 | PAK4 | 1.31046485 |
| 38 | CDK7 | 1.29060580 |
| 39 | ACVR1B | 1.27434349 |
| 40 | TGFBR1 | 1.27286321 |
| 41 | BRSK1 | 1.22169235 |
| 42 | PLK4 | 1.21083509 |
| 43 | AURKB | 1.21019035 |
| 44 | RPS6KB2 | 1.19683153 |
| 45 | ZAP70 | 1.18623072 |
| 46 | PLK1 | 1.14254649 |
| 47 | RPS6KA4 | 1.13266551 |
| 48 | MUSK | 1.10112472 |
| 49 | KIT | 1.08640797 |
| 50 | LIMK1 | 1.07005111 |
| 51 | EEF2K | 1.02971840 |
| 52 | NEK1 | 0.98251639 |
| 53 | MYLK | 0.97525354 |
| 54 | MAPKAPK3 | 0.97484511 |
| 55 | STK4 | 0.96802607 |
| 56 | EIF2AK2 | 0.96455114 |
| 57 | CSF1R | 0.95646753 |
| 58 | AURKA | 0.95560093 |
| 59 | BTK | 0.95444668 |
| 60 | CDK8 | 0.95406710 |
| 61 | LRRK2 | 0.93253130 |
| 62 | TTK | 0.91794225 |
| 63 | ATR | 0.91286493 |
| 64 | PKN2 | 0.89653765 |
| 65 | BRAF | 0.89648832 |
| 66 | TBK1 | 0.88099056 |
| 67 | MST4 | 0.86452407 |
| 68 | ILK | 0.83572800 |
| 69 | ZAK | 0.82766118 |
| 70 | CDK4 | 0.82613430 |
| 71 | NME1 | 0.82156574 |
| 72 | TRIB3 | 0.82022112 |
| 73 | JAK3 | 0.81665574 |
| 74 | MAP3K8 | 0.79579712 |
| 75 | CHEK2 | 0.77089947 |
| 76 | PLK3 | 0.74546535 |
| 77 | TEC | 0.74378787 |
| 78 | GRK6 | 0.70208353 |
| 79 | SIK3 | 0.70019823 |
| 80 | CSNK2A1 | 0.68725705 |
| 81 | PIM1 | 0.68324435 |
| 82 | MKNK1 | 0.67008539 |
| 83 | IKBKB | 0.66795904 |
| 84 | PAK1 | 0.65975576 |
| 85 | TYK2 | 0.64285072 |
| 86 | CSNK1G3 | 0.64168993 |
| 87 | ERN1 | 0.63948017 |
| 88 | MAP3K12 | 0.63536690 |
| 89 | MAPK11 | 0.63076146 |
| 90 | BMX | 0.62066858 |
| 91 | NUAK1 | 0.60671245 |
| 92 | CLK1 | 0.60497455 |
| 93 | IRAK4 | 0.59148406 |
| 94 | STK10 | 0.58438773 |
| 95 | SYK | 0.57836855 |
| 96 | EPHA2 | 0.57541579 |
| 97 | DAPK1 | 0.57443013 |
| 98 | DAPK3 | 0.56321864 |
| 99 | DYRK2 | 0.56176996 |
| 100 | MAP2K2 | 0.54834531 |
| 101 | CHEK1 | 0.53253389 |
| 102 | PDK2 | 0.53169646 |
| 103 | TSSK6 | 0.53134574 |
| 104 | TAF1 | 0.52518724 |
| 105 | MARK3 | 0.50078182 |
| 106 | ABL2 | 0.49695620 |
| 107 | RPS6KA6 | 0.49375517 |
| 108 | RPS6KC1 | 0.48378914 |
| 109 | RPS6KL1 | 0.48378914 |
| 110 | MAP4K2 | 0.47746607 |
| 111 | CSNK2A2 | 0.47243814 |
| 112 | MAP3K3 | 0.46178637 |
| 113 | TXK | 0.45848728 |
| 114 | ARAF | 0.45401585 |
| 115 | SCYL2 | 0.45344219 |
| 116 | IRAK3 | 0.45050838 |
| 117 | RIPK4 | 0.44618829 |
| 118 | LYN | 0.43820477 |
| 119 | RPS6KA5 | 0.42133331 |
| 120 | MAP3K5 | 0.38758745 |
| 121 | PRPF4B | 0.37082669 |
| 122 | RAF1 | 0.36036597 |
| 123 | GRK5 | 0.32887382 |
| 124 | MST1R | 0.29595347 |
| 125 | CDK2 | 0.28208468 |
| 126 | CDK11A | 0.27660123 |
| 127 | CDK14 | 0.27168258 |
| 128 | CSNK1A1L | 0.26677178 |
| 129 | PRKCI | 0.25724692 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.85349380 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.29997371 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 3.45079324 |
| 4 | Mismatch repair_Homo sapiens_hsa03430 | 3.31732020 |
| 5 | Base excision repair_Homo sapiens_hsa03410 | 2.68930292 |
| 6 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.46911342 |
| 7 | Homologous recombination_Homo sapiens_hsa03440 | 2.41695509 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.33964869 |
| 9 | Spliceosome_Homo sapiens_hsa03040 | 2.32831866 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.32649574 |
| 11 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.07250364 |
| 12 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.96826491 |
| 13 | RNA transport_Homo sapiens_hsa03013 | 1.76480645 |
| 14 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.69911675 |
| 15 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.69315085 |
| 16 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.60648446 |
| 17 | Parkinsons disease_Homo sapiens_hsa05012 | 1.52222644 |
| 18 | Sulfur relay system_Homo sapiens_hsa04122 | 1.50250894 |
| 19 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.47394228 |
| 20 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.46329275 |
| 21 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.45556935 |
| 22 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.45198851 |
| 23 | Cell cycle_Homo sapiens_hsa04110 | 1.41508884 |
| 24 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.41379669 |
| 25 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.33269079 |
| 26 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.30787168 |
| 27 | Basal transcription factors_Homo sapiens_hsa03022 | 1.27693510 |
| 28 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.27372483 |
| 29 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.26183640 |
| 30 | Huntingtons disease_Homo sapiens_hsa05016 | 1.24540109 |
| 31 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.24313445 |
| 32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.23984478 |
| 33 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.23584607 |
| 34 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.23160484 |
| 35 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.22859580 |
| 36 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.22662815 |
| 37 | Carbon metabolism_Homo sapiens_hsa01200 | 1.17669950 |
| 38 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.17420382 |
| 39 | Purine metabolism_Homo sapiens_hsa00230 | 1.16451612 |
| 40 | RNA degradation_Homo sapiens_hsa03018 | 1.15170411 |
| 41 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.14061433 |
| 42 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.10610599 |
| 43 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.09645605 |
| 44 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.06833117 |
| 45 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.06064544 |
| 46 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.03395773 |
| 47 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.02144064 |
| 48 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.02125302 |
| 49 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.01559490 |
| 50 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.99868069 |
| 51 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.97280970 |
| 52 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.95077514 |
| 53 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.92922948 |
| 54 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.90959695 |
| 55 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.86559029 |
| 56 | Peroxisome_Homo sapiens_hsa04146 | 0.84868275 |
| 57 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.83482462 |
| 58 | Other glycan degradation_Homo sapiens_hsa00511 | 0.82245993 |
| 59 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.80260061 |
| 60 | Protein export_Homo sapiens_hsa03060 | 0.79544828 |
| 61 | Alzheimers disease_Homo sapiens_hsa05010 | 0.77293117 |
| 62 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.75624467 |
| 63 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.75443840 |
| 64 | Galactose metabolism_Homo sapiens_hsa00052 | 0.73681663 |
| 65 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.71939786 |
| 66 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.70743664 |
| 67 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.66243769 |
| 68 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.63524535 |
| 69 | Metabolic pathways_Homo sapiens_hsa01100 | 0.63307630 |
| 70 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.60470979 |
| 71 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.59712077 |
| 72 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.56314182 |
| 73 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.55106508 |
| 74 | Legionellosis_Homo sapiens_hsa05134 | 0.54415832 |
| 75 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.54091984 |
| 76 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.52945530 |
| 77 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.50227939 |
| 78 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.48572395 |
| 79 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.48428991 |
| 80 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.46147151 |
| 81 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.45962362 |
| 82 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.45783531 |
| 83 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.45160249 |
| 84 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.44309260 |
| 85 | Viral myocarditis_Homo sapiens_hsa05416 | 0.43771126 |
| 86 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.43599144 |
| 87 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.43556937 |
| 88 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.42000091 |
| 89 | Allograft rejection_Homo sapiens_hsa05330 | 0.40869175 |
| 90 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.40357430 |
| 91 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.39344430 |
| 92 | Measles_Homo sapiens_hsa05162 | 0.39336908 |
| 93 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.39276875 |
| 94 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.38748733 |
| 95 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.38713092 |
| 96 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.38451884 |
| 97 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.34427474 |
| 98 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.33767475 |
| 99 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.30774006 |
| 100 | Retinol metabolism_Homo sapiens_hsa00830 | 0.30725463 |
| 101 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.30635005 |
| 102 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.29416352 |
| 103 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.29207159 |
| 104 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.28837804 |
| 105 | Shigellosis_Homo sapiens_hsa05131 | 0.28800717 |
| 106 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.28625796 |
| 107 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.28408276 |
| 108 | Influenza A_Homo sapiens_hsa05164 | 0.27418989 |
| 109 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.27380093 |
| 110 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.27199803 |
| 111 | Asthma_Homo sapiens_hsa05310 | 0.27138979 |
| 112 | HTLV-I infection_Homo sapiens_hsa05166 | 0.26837170 |
| 113 | Leishmaniasis_Homo sapiens_hsa05140 | 0.26282418 |
| 114 | Apoptosis_Homo sapiens_hsa04210 | 0.25803856 |
| 115 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.25756205 |
| 116 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.23532110 |
| 117 | Alcoholism_Homo sapiens_hsa05034 | 0.21993283 |
| 118 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.20029578 |
| 119 | Lysine degradation_Homo sapiens_hsa00310 | 0.16927336 |
| 120 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.15818328 |
| 121 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.14875368 |

