PIH1D3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.81846084
2cell-cell recognition (GO:0009988)9.74000375
3reproduction (GO:0000003)9.41713384
4acrosome reaction (GO:0007340)9.36384371
5male meiosis (GO:0007140)9.30755468
6motile cilium assembly (GO:0044458)9.23842568
7cilium movement (GO:0003341)9.11969103
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.05755738
9spermatid development (GO:0007286)9.01859131
10synaptonemal complex organization (GO:0070193)8.63616823
11synaptonemal complex assembly (GO:0007130)8.26837745
12single fertilization (GO:0007338)7.17499498
13DNA methylation involved in gamete generation (GO:0043046)6.61836221
14sperm capacitation (GO:0048240)6.54909141
15regulation of cilium movement (GO:0003352)6.36794789
16fertilization (GO:0009566)6.28853411
17spermatid nucleus differentiation (GO:0007289)6.24336473
18chromosome organization involved in meiosis (GO:0070192)6.09478483
19male meiosis I (GO:0007141)5.84720592
20negative regulation of inclusion body assembly (GO:0090084)5.80996197
21spermatogenesis (GO:0007283)5.57761319
22male gamete generation (GO:0048232)5.55557275
23ventricular system development (GO:0021591)5.30855404
24meiotic nuclear division (GO:0007126)5.29064278
25germ cell development (GO:0007281)5.27658667
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.17144293
27gamete generation (GO:0007276)5.12409512
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.93303639
29seminiferous tubule development (GO:0072520)4.79712891
30cell recognition (GO:0008037)4.71869728
31regulation of inclusion body assembly (GO:0090083)4.64649078
32microtubule bundle formation (GO:0001578)4.64100714
33meiosis I (GO:0007127)4.62195333
34sexual reproduction (GO:0019953)4.62097358
35meiotic cell cycle (GO:0051321)4.53201717
36vitamin transmembrane transport (GO:0035461)4.52501535
37tolerance induction (GO:0002507)4.50108190
38calcium ion-dependent exocytosis (GO:0017156)4.43249293
39organic cation transport (GO:0015695)4.42605619
40response to xenobiotic stimulus (GO:0009410)4.36252726
41genitalia morphogenesis (GO:0035112)4.36245386
42one-carbon compound transport (GO:0019755)4.30284930
43single strand break repair (GO:0000012)4.27432996
44microtubule depolymerization (GO:0007019)4.27173353
45fucose catabolic process (GO:0019317)4.22516593
46L-fucose metabolic process (GO:0042354)4.22516593
47L-fucose catabolic process (GO:0042355)4.22516593
48protein localization to cilium (GO:0061512)4.20297254
49exogenous drug catabolic process (GO:0042738)4.19984263
50monoubiquitinated protein deubiquitination (GO:0035520)4.10785000
51synapsis (GO:0007129)4.06995788
52primary alcohol catabolic process (GO:0034310)4.06007279
53multicellular organismal reproductive process (GO:0048609)4.03089578
54cornea development in camera-type eye (GO:0061303)3.96966583
55microtubule severing (GO:0051013)3.94923721
56protein polyglutamylation (GO:0018095)3.88425203
57pyrimidine-containing compound transmembrane transport (GO:0072531)3.80364840
58nonmotile primary cilium assembly (GO:0035058)3.78313215
59negative regulation of T cell differentiation in thymus (GO:0033085)3.77495602
60intraciliary transport (GO:0042073)3.77325048
61behavioral response to nicotine (GO:0035095)3.76682784
62regulation of protein polyubiquitination (GO:1902914)3.72423125
63left/right pattern formation (GO:0060972)3.71924586
64protein K11-linked deubiquitination (GO:0035871)3.71739878
65diterpenoid biosynthetic process (GO:0016102)3.71186655
66axoneme assembly (GO:0035082)3.66311548
67gene silencing by RNA (GO:0031047)3.65554679
68regulation of microtubule-based movement (GO:0060632)3.65119893
69polyol catabolic process (GO:0046174)3.64326709
70drug catabolic process (GO:0042737)3.58083441
71cell projection assembly (GO:0030031)3.53486419
72lactate metabolic process (GO:0006089)3.50860156
73terpenoid biosynthetic process (GO:0016114)3.48322460
74centriole replication (GO:0007099)3.45856479
75microtubule-based movement (GO:0007018)3.45048662
76glycerol ether metabolic process (GO:0006662)3.43186052
77photoreceptor cell maintenance (GO:0045494)3.40761768
78meiotic cell cycle process (GO:1903046)3.38536887
79regulation of centriole replication (GO:0046599)3.37413367
80multicellular organismal development (GO:0007275)3.28092082
81retinal cone cell development (GO:0046549)3.27636914
82alditol metabolic process (GO:0019400)3.26869535
83ethanol metabolic process (GO:0006067)3.23099296
84regulation of meiosis I (GO:0060631)3.22334527
85negative regulation of DNA repair (GO:0045738)3.21262018
86cilium organization (GO:0044782)3.20385342
87neural tube formation (GO:0001841)3.18425268
88centriole assembly (GO:0098534)3.17427946
89ether metabolic process (GO:0018904)3.16009722
90carnitine transmembrane transport (GO:1902603)3.13249037
91nucleosome disassembly (GO:0006337)3.11842187
92protein-DNA complex disassembly (GO:0032986)3.11842187
93carnitine transport (GO:0015879)3.09039365
94amino-acid betaine transport (GO:0015838)3.09039365
95platelet dense granule organization (GO:0060155)3.05738430
96glycerol metabolic process (GO:0006071)3.05118288
97chaperone-mediated protein complex assembly (GO:0051131)3.05001855
98cilium assembly (GO:0042384)3.04196914
99negative regulation of organelle assembly (GO:1902116)3.00466356
100protein refolding (GO:0042026)2.99759891
101cellular ketone body metabolic process (GO:0046950)2.98376630
102determination of left/right symmetry (GO:0007368)2.94938549
103smoothened signaling pathway (GO:0007224)2.93168449
104regulation of germinal center formation (GO:0002634)2.91518309
105cellular component assembly involved in morphogenesis (GO:0010927)2.91036607
106negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89462428
107gene silencing (GO:0016458)2.89386656
108response to pheromone (GO:0019236)2.88981392
109retinoic acid metabolic process (GO:0042573)2.86739273
110regulation of interleukin-5 production (GO:0032674)2.81731111
111nuclear pore complex assembly (GO:0051292)2.80163250
112nucleus organization (GO:0006997)2.75878817
113determination of bilateral symmetry (GO:0009855)2.75537161
114detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.75189121
115histone exchange (GO:0043486)2.72454176
116glycolytic process (GO:0006096)2.71196376
117ketone body metabolic process (GO:1902224)2.71054046
118nucleoside diphosphate phosphorylation (GO:0006165)2.69616730
119rRNA catabolic process (GO:0016075)2.68903851
120cytoplasmic microtubule organization (GO:0031122)2.68653166
121fucosylation (GO:0036065)2.68592359
122detection of light stimulus involved in sensory perception (GO:0050962)2.67186008
123detection of light stimulus involved in visual perception (GO:0050908)2.67186008
124specification of symmetry (GO:0009799)2.66985692
125aldehyde catabolic process (GO:0046185)2.66026394
126calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.63432439
127sister chromatid cohesion (GO:0007062)2.61892216
128cilium morphogenesis (GO:0060271)2.58066312
129left/right axis specification (GO:0070986)2.56210306
130mitotic sister chromatid cohesion (GO:0007064)2.54036137
131ubiquinone biosynthetic process (GO:0006744)2.50461480
132hydrogen peroxide biosynthetic process (GO:0050665)2.49273229
133preassembly of GPI anchor in ER membrane (GO:0016254)2.47914912
134negative regulation of immunoglobulin mediated immune response (GO:0002890)2.47841004
135negative regulation of B cell mediated immunity (GO:0002713)2.47841004
136protein-cofactor linkage (GO:0018065)2.46262476
137glutathione derivative metabolic process (GO:1901685)2.42020988
138glutathione derivative biosynthetic process (GO:1901687)2.42020988
139cytochrome complex assembly (GO:0017004)2.35018059
140protein complex biogenesis (GO:0070271)2.34009207
141regulation of collateral sprouting (GO:0048670)2.33885173
142respiratory chain complex IV assembly (GO:0008535)2.33742140
143magnesium ion transport (GO:0015693)2.32771120
144amino-acid betaine metabolic process (GO:0006577)2.32590417
145neurotransmitter metabolic process (GO:0042133)2.30089381
146embryonic epithelial tube formation (GO:0001838)2.29148670
147negative regulation of humoral immune response (GO:0002921)2.28608315
148lung epithelium development (GO:0060428)2.28076141
149reactive oxygen species biosynthetic process (GO:1903409)2.27750793
150amine catabolic process (GO:0009310)2.26964667
151cellular biogenic amine catabolic process (GO:0042402)2.26964667
152photoreceptor cell development (GO:0042461)2.26786186
153retinol metabolic process (GO:0042572)2.26272984
154positive regulation of tolerance induction (GO:0002645)2.25794673
155cilium or flagellum-dependent cell motility (GO:0001539)15.9982155
156fusion of sperm to egg plasma membrane (GO:0007342)12.8575878
157sperm motility (GO:0030317)12.5714571
158cell wall macromolecule catabolic process (GO:0016998)11.1839216
159cell wall macromolecule metabolic process (GO:0044036)11.1839216
160axonemal dynein complex assembly (GO:0070286)10.9186877
161multicellular organism reproduction (GO:0032504)10.7874653
162sperm-egg recognition (GO:0035036)10.6671868
163epithelial cilium movement (GO:0003351)10.6055915
164acrosome assembly (GO:0001675)10.5591952
165piRNA metabolic process (GO:0034587)10.4320122
166binding of sperm to zona pellucida (GO:0007339)10.0675209

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.69596420
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.34646977
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.43241319
4FLI1_27457419_Chip-Seq_LIVER_Mouse2.80765736
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72548936
6IGF1R_20145208_ChIP-Seq_DFB_Human2.58957166
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35920882
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29880815
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25018309
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22378863
11EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.21612004
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10544178
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.9454059
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95246735
15ZNF274_21170338_ChIP-Seq_K562_Hela1.91478735
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.88261829
17GBX2_23144817_ChIP-Seq_PC3_Human1.88120762
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86677378
19CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.85357991
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83969836
21KAP1_22055183_ChIP-Seq_ESCs_Mouse1.83313990
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.82423498
23RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.79854955
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.77350254
25GATA1_26923725_Chip-Seq_HPCs_Mouse1.76367799
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75839554
27EWS_26573619_Chip-Seq_HEK293_Human1.71292829
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.68494051
29FUS_26573619_Chip-Seq_HEK293_Human1.63775360
30P300_19829295_ChIP-Seq_ESCs_Human1.62796614
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.62571970
32BCAT_22108803_ChIP-Seq_LS180_Human1.60902643
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.60585937
34TAL1_26923725_Chip-Seq_HPCs_Mouse1.60388037
35DROSHA_22980978_ChIP-Seq_HELA_Human1.60358729
36KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.58952614
37TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.58554851
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57846201
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56932216
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.56847183
41TAF15_26573619_Chip-Seq_HEK293_Human1.55726717
42IRF1_19129219_ChIP-ChIP_H3396_Human1.54872177
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54420819
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53746542
45KDM2B_26808549_Chip-Seq_REH_Human1.53659573
46STAT1_17558387_ChIP-Seq_HELA_Human1.50895749
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.48405776
48SMAD4_21799915_ChIP-Seq_A2780_Human1.44251163
49TCF4_22108803_ChIP-Seq_LS180_Human1.43347627
50GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.42688367
51ELK4_26923725_Chip-Seq_MESODERM_Mouse1.39082314
52AR_20517297_ChIP-Seq_VCAP_Human1.39071596
53STAT3_23295773_ChIP-Seq_U87_Human1.38321708
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37560222
55MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37245571
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37173155
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34149233
58VDR_22108803_ChIP-Seq_LS180_Human1.33433296
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32517076
60NCOR_22424771_ChIP-Seq_293T_Human1.31922957
61CBP_20019798_ChIP-Seq_JUKART_Human1.31747903
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31747903
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.30447631
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30329427
65REST_21632747_ChIP-Seq_MESCs_Mouse1.30144171
66HOXB7_26014856_ChIP-Seq_BT474_Human1.29455290
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28809258
68OCT4_18555785_Chip-Seq_ESCs_Mouse1.28404048
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28075830
70SOX2_19829295_ChIP-Seq_ESCs_Human1.27923447
71NANOG_19829295_ChIP-Seq_ESCs_Human1.27923447
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27221791
73MYC_19829295_ChIP-Seq_ESCs_Human1.25896490
74TP53_22573176_ChIP-Seq_HFKS_Human1.25554713
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.24820702
76FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24695204
77GATA3_21867929_ChIP-Seq_CD8_Mouse1.23608252
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.23527242
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22947112
80SOX2_22085726_ChIP-Seq_NPCs_Mouse1.22190611
81P53_22387025_ChIP-Seq_ESCs_Mouse1.21375736
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21325992
83P300_18555785_Chip-Seq_ESCs_Mouse1.20926313
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20857102
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20379300
86AR_25329375_ChIP-Seq_VCAP_Human1.20058872
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.19963733
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18715141
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18611216
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.18450497
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.18278587
92PHF8_20622853_ChIP-Seq_HELA_Human1.16407865
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15982737
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.15492046
95AR_21572438_ChIP-Seq_LNCaP_Human1.15319556
96ERA_21632823_ChIP-Seq_H3396_Human1.13473980
97ETV1_20927104_ChIP-Seq_GIST48_Human1.12917869
98RUNX2_22187159_ChIP-Seq_PCA_Human1.12711365
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11830646
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11394387
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.10970612
102KLF4_18555785_Chip-Seq_ESCs_Mouse1.10844231
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10759248
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10759248
105SMRT_27268052_Chip-Seq_Bcells_Human1.09812178
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08458387
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08276892
108ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07812883
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07602041
110GATA3_21867929_ChIP-Seq_TH1_Mouse1.07119899
111TAF2_19829295_ChIP-Seq_ESCs_Human1.07035042
112ESET_19884257_ChIP-Seq_ESCs_Mouse1.06553173
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06355740
114CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05973799
115TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05869105
116CDX2_22108803_ChIP-Seq_LS180_Human1.05196195
117ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05019435
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.04804234
119NANOG_20526341_ChIP-Seq_ESCs_Human1.04601867
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04518800
121BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03720679
122TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03698849
123GF1_26923725_Chip-Seq_HPCs_Mouse1.03491661
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03426568
125RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03146675
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02939386
127STAT1_20625510_ChIP-Seq_HELA_Human1.02865892
128OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02677893
129EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02454198
130GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01965841
131RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01779379
132RBPJ_21746931_ChIP-Seq_IB4_Human1.01627441
133RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01493887
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01213993
135SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00809073
136PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00279495
137HNFA_21074721_ChIP-Seq_CACO-2_Human0.99976608
138LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.99370155
139CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99354914
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99340340
141CTCF_18555785_Chip-Seq_ESCs_Mouse0.98935866
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.98616027
143SALL1_21062744_ChIP-ChIP_HESCs_Human0.98417058
144RNF2_27304074_Chip-Seq_NSC_Mouse0.98191780
145PU1_27457419_Chip-Seq_LIVER_Mouse0.97936848
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97746826
147SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.97043870
148SMAD1_18555785_Chip-Seq_ESCs_Mouse0.97011687
149TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93672001
150PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93461100
151NMYC_18555785_Chip-Seq_ESCs_Mouse0.93367600
152PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93016996
153EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92118235
154SPI1_26923725_Chip-Seq_HPCs_Mouse0.91981935
155SOX2_18555785_Chip-Seq_ESCs_Mouse0.91815409
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.90817120
157ERG_20517297_ChIP-Seq_VCAP_Human0.90274037
158ZFX_18555785_Chip-Seq_ESCs_Mouse0.89155656
159GF1B_26923725_Chip-Seq_HPCs_Mouse0.88936136
160SOX9_26525672_Chip-Seq_HEART_Mouse0.88922144
161TCF4_23295773_ChIP-Seq_U87_Human0.88794824
162ER_23166858_ChIP-Seq_MCF-7_Human0.87044474
163P53_21459846_ChIP-Seq_SAOS-2_Human0.86924616
164SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86351081
165FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85314214
166CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85270190
167FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84952671

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04302194
2MP0008877_abnormal_DNA_methylation5.67997758
3MP0001929_abnormal_gametogenesis5.61450882
4MP0002210_abnormal_sex_determination4.01784080
5MP0004043_abnormal_pH_regulation3.33537470
6MP0001145_abnormal_male_reproductive3.31850459
7MP0002161_abnormal_fertility/fecundity3.21147426
8MP0000653_abnormal_sex_gland2.87309996
9MP0003195_calcinosis2.87241997
10MP0004133_heterotaxia2.67068645
11MP0002653_abnormal_ependyma_morphology2.57707653
12MP0005623_abnormal_meninges_morphology2.42021420
13MP0008789_abnormal_olfactory_epithelium2.40303745
14MP0002876_abnormal_thyroid_physiology2.39427822
15MP0002277_abnormal_respiratory_mucosa2.35533991
16MP0005084_abnormal_gallbladder_morpholo2.32331477
17MP0005645_abnormal_hypothalamus_physiol2.22149985
18MP0008872_abnormal_physiological_respon2.16708099
19MP0005410_abnormal_fertilization14.8375858
20MP0008057_abnormal_DNA_replication1.90112578
21MP0003252_abnormal_bile_duct1.89298910
22MP0009780_abnormal_chondrocyte_physiolo1.83148320
23MP0002160_abnormal_reproductive_system1.80727774
24MP0005075_abnormal_melanosome_morpholog1.76838659
25MP0008058_abnormal_DNA_repair1.76019283
26MP0005083_abnormal_biliary_tract1.75830162
27MP0000569_abnormal_digit_pigmentation1.69299792
28MP0004885_abnormal_endolymph1.63854065
29MP0002638_abnormal_pupillary_reflex1.62233637
30MP0005394_taste/olfaction_phenotype1.44342860
31MP0005499_abnormal_olfactory_system1.44342860
32MP0000372_irregular_coat_pigmentation1.44054507
33MP0002909_abnormal_adrenal_gland1.42387348
34MP0005365_abnormal_bile_salt1.41823433
35MP0005085_abnormal_gallbladder_physiolo1.41759870
36MP0003011_delayed_dark_adaptation1.41373555
37MP0005174_abnormal_tail_pigmentation1.34687368
38MP0005670_abnormal_white_adipose1.34006209
39MP0009745_abnormal_behavioral_response1.33068796
40MP0002282_abnormal_trachea_morphology1.32984723
41MP0000383_abnormal_hair_follicle1.32368298
42MP0004264_abnormal_extraembryonic_tissu1.30972018
43MP0003718_maternal_effect1.28927178
44MP0002837_dystrophic_cardiac_calcinosis1.24407632
45MP0004808_abnormal_hematopoietic_stem1.24295108
46MP0005647_abnormal_sex_gland1.21130891
47MP0000631_abnormal_neuroendocrine_gland1.21065510
48MP0001970_abnormal_pain_threshold1.20479437
49MP0001485_abnormal_pinna_reflex1.19789104
50MP0002272_abnormal_nervous_system1.17246134
51MP0002009_preneoplasia1.15285445
52MP0001501_abnormal_sleep_pattern1.11147099
53MP0001765_abnormal_ion_homeostasis1.10686256
54MP0002733_abnormal_thermal_nociception1.09424476
55MP0005408_hypopigmentation1.08341958
56MP0002163_abnormal_gland_morphology1.06994382
57MP0002557_abnormal_social/conspecific_i1.03114197
58MP0010678_abnormal_skin_adnexa1.02728996
59MP0001529_abnormal_vocalization1.01885664
60MP0000015_abnormal_ear_pigmentation1.00209684
61MP0010094_abnormal_chromosome_stability0.99891159
62MP0001984_abnormal_olfaction0.99069869
63MP0004142_abnormal_muscle_tone0.97607486
64MP0010386_abnormal_urinary_bladder0.96400871
65MP0001664_abnormal_digestion0.96347792
66MP0009046_muscle_twitch0.95033501
67MP0000566_synostosis0.94490846
68MP0001486_abnormal_startle_reflex0.89270571
69MP0004742_abnormal_vestibular_system0.88467197
70MP0002735_abnormal_chemical_nociception0.87264854
71MP0006292_abnormal_olfactory_placode0.86008808
72MP0001944_abnormal_pancreas_morphology0.85140507
73MP0005195_abnormal_posterior_eye0.84911673
74MP0002095_abnormal_skin_pigmentation0.84585556
75MP0001502_abnormal_circadian_rhythm0.84145898
76MP0009764_decreased_sensitivity_to0.82783643
77MP0000026_abnormal_inner_ear0.82021607
78MP0010329_abnormal_lipoprotein_level0.81125118
79MP0005389_reproductive_system_phenotype0.80915933
80MP0002572_abnormal_emotion/affect_behav0.80812141
81MP0005395_other_phenotype0.80058793
82MP0008007_abnormal_cellular_replicative0.78002319
83MP0001764_abnormal_homeostasis0.77865146
84MP0005332_abnormal_amino_acid0.77816990
85MP0002734_abnormal_mechanical_nocicepti0.77781834
86MP0002168_other_aberrant_phenotype0.77428572
87MP0002064_seizures0.77107606
88MP0003136_yellow_coat_color0.76967579
89MP0004134_abnormal_chest_morphology0.76783025
90MP0000685_abnormal_immune_system0.74923119
91MP0004215_abnormal_myocardial_fiber0.72847968
92MP0005167_abnormal_blood-brain_barrier0.72388518
93MP0004130_abnormal_muscle_cell0.71278789
94MP0002067_abnormal_sensory_capabilities0.69961799
95MP0009643_abnormal_urine_homeostasis0.69519894
96MP0002693_abnormal_pancreas_physiology0.68371484
97MP0003786_premature_aging0.66531199
98MP0004233_abnormal_muscle_weight0.64014913
99MP0008995_early_reproductive_senescence0.63462394
100MP0003183_abnormal_peptide_metabolism0.63050232
101MP0000749_muscle_degeneration0.61970770
102MP0001119_abnormal_female_reproductive0.61637817
103MP0000751_myopathy0.61271359
104MP0002102_abnormal_ear_morphology0.60817547
105MP0002736_abnormal_nociception_after0.60810431
106MP0003115_abnormal_respiratory_system0.59389548
107MP0003646_muscle_fatigue0.58892824
108MP0003315_abnormal_perineum_morphology0.57469759
109MP0000358_abnormal_cell_content/0.57461288
110MP0002234_abnormal_pharynx_morphology0.53927332
111MP0003950_abnormal_plasma_membrane0.53396491
112MP0005636_abnormal_mineral_homeostasis0.51863167
113MP0001727_abnormal_embryo_implantation0.50474567
114MP0004019_abnormal_vitamin_homeostasis0.48371859
115MP0003878_abnormal_ear_physiology0.47436066
116MP0005377_hearing/vestibular/ear_phenot0.47436066
117MP0001293_anophthalmia0.46572247
118MP0008004_abnormal_stomach_pH0.45398024
119MP0003943_abnormal_hepatobiliary_system0.45308026
120MP0005551_abnormal_eye_electrophysiolog0.43821096
121MP0010307_abnormal_tumor_latency0.43787353
122MP0006072_abnormal_retinal_apoptosis0.43511501
123MP0003699_abnormal_female_reproductive0.41021883
124MP0005187_abnormal_penis_morphology0.40807545
125MP0001545_abnormal_hematopoietic_system0.39926642
126MP0005397_hematopoietic_system_phenotyp0.39926642
127MP0005646_abnormal_pituitary_gland0.39821521
128MP0002139_abnormal_hepatobiliary_system0.38914949
129MP0002132_abnormal_respiratory_system0.38545734
130MP0002928_abnormal_bile_duct0.37108436
131MP0001968_abnormal_touch/_nociception0.36030711
132MP0002796_impaired_skin_barrier0.35406366
133MP0005253_abnormal_eye_physiology0.35037665
134MP0004145_abnormal_muscle_electrophysio0.33839750
135MP0002971_abnormal_brown_adipose0.32739991
136MP0005391_vision/eye_phenotype0.32080881
137MP0006036_abnormal_mitochondrial_physio0.31011828
138MP0003633_abnormal_nervous_system0.30707113
139MP0005671_abnormal_response_to0.30647356
140MP0001849_ear_inflammation0.30223123
141MP0002405_respiratory_system_inflammati0.30017204
142MP0002269_muscular_atrophy0.29756347
143MP0004036_abnormal_muscle_relaxation0.28302647
144MP0001324_abnormal_eye_pigmentation0.28176208
145MP0009278_abnormal_bone_marrow0.28018862
146MP0001851_eye_inflammation0.26935248
147MP0004270_analgesia0.25741843
148MP0000313_abnormal_cell_death0.24669351
149MP0008875_abnormal_xenobiotic_pharmacok0.24487208
150MP0002396_abnormal_hematopoietic_system0.23547666
151MP0008569_lethality_at_weaning0.22875056
152MP0003111_abnormal_nucleus_morphology0.22115835
153MP0001986_abnormal_taste_sensitivity0.21793093
154MP0002092_abnormal_eye_morphology0.21520146
155MP0003631_nervous_system_phenotype0.20728891
156MP0000647_abnormal_sebaceous_gland0.19353385
157MP0005464_abnormal_platelet_physiology0.18830282
158MP0001661_extended_life_span0.18522121
159MP0003436_decreased_susceptibility_to0.17924741
160MP0008874_decreased_physiological_sensi0.17349983
161MP0000427_abnormal_hair_cycle0.16998987
162MP0006035_abnormal_mitochondrial_morpho0.16713974
163MP0003077_abnormal_cell_cycle0.15724905
164MP0005666_abnormal_adipose_tissue0.15445580
165MP0010630_abnormal_cardiac_muscle0.15410437
166MP0002118_abnormal_lipid_homeostasis0.15300883
167MP0002229_neurodegeneration0.14668156

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.47110040
2Abnormal respiratory motile cilium morphology (HP:0005938)8.98308310
3Abnormal respiratory epithelium morphology (HP:0012253)8.98308310
4Rhinitis (HP:0012384)7.99732303
5Abnormal ciliary motility (HP:0012262)7.77595807
6Chronic bronchitis (HP:0004469)7.49323331
7Nasal polyposis (HP:0100582)6.29961870
8Infertility (HP:0000789)5.74615290
9Abnormality of the nasal mucosa (HP:0000433)5.17125884
10Bronchiectasis (HP:0002110)4.55831853
11Nephronophthisis (HP:0000090)4.42362699
12Abnormality of the lower motor neuron (HP:0002366)4.38066144
13Bronchitis (HP:0012387)4.32755267
14Chronic hepatic failure (HP:0100626)3.70089805
15Abnormality of the renal medulla (HP:0100957)3.44740524
16Recurrent sinusitis (HP:0011108)3.44084869
17Occipital encephalocele (HP:0002085)3.41714849
18Recurrent otitis media (HP:0000403)3.37511892
19Tubulointerstitial nephritis (HP:0001970)3.25961879
20Amyotrophic lateral sclerosis (HP:0007354)3.00148162
21Gonadotropin excess (HP:0000837)2.91989984
22Medial flaring of the eyebrow (HP:0010747)2.62125533
23Fibular hypoplasia (HP:0003038)2.59093016
24Male infertility (HP:0003251)2.51028762
25Molar tooth sign on MRI (HP:0002419)2.47700846
26Abnormality of midbrain morphology (HP:0002418)2.47700846
27Tubular atrophy (HP:0000092)2.45892903
28Type II lissencephaly (HP:0007260)2.44150758
29Upper motor neuron abnormality (HP:0002127)2.44102679
30Chronic otitis media (HP:0000389)2.43164967
31Congenital stationary night blindness (HP:0007642)2.41628735
32Tubulointerstitial abnormality (HP:0001969)2.38688604
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31961857
34Abnormal rod and cone electroretinograms (HP:0008323)2.29927455
35Impaired proprioception (HP:0010831)2.29653122
36Anencephaly (HP:0002323)2.27574622
37Abnormal spermatogenesis (HP:0008669)2.26138185
38Sclerocornea (HP:0000647)2.23289244
39Recurrent bronchitis (HP:0002837)2.21709891
40Postaxial foot polydactyly (HP:0001830)2.16622498
41Decreased central vision (HP:0007663)2.12220472
42Male pseudohermaphroditism (HP:0000037)2.08830541
43Abolished electroretinogram (ERG) (HP:0000550)2.08057483
44Abnormality of the anterior horn cell (HP:0006802)2.07742081
45Degeneration of anterior horn cells (HP:0002398)2.07742081
46Stage 5 chronic kidney disease (HP:0003774)2.05863685
47Furrowed tongue (HP:0000221)2.05735215
48Supernumerary spleens (HP:0009799)2.03025681
49Chronic sinusitis (HP:0011109)2.02260149
50Polyuria (HP:0000103)2.00621269
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5457796
52Absent/shortened dynein arms (HP:0200106)12.7662304
53Dynein arm defect of respiratory motile cilia (HP:0012255)12.7662304
54Absent frontal sinuses (HP:0002688)1.96409739
55Breast carcinoma (HP:0003002)1.95278718
56Abnormality of the renal cortex (HP:0011035)1.95018991
57Bile duct proliferation (HP:0001408)1.94586172
58Abnormal biliary tract physiology (HP:0012439)1.94586172
59Abnormality of permanent molar morphology (HP:0011071)1.92274826
60Abnormality of the dental root (HP:0006486)1.92274826
61Taurodontia (HP:0000679)1.92274826
62Abnormality of macular pigmentation (HP:0008002)1.91839136
63Hyperactive renin-angiotensin system (HP:0000841)1.90757010
64Aplasia/Hypoplasia of the spleen (HP:0010451)1.90686996
65Congenital hepatic fibrosis (HP:0002612)1.89424860
66Abnormality of dentin (HP:0010299)1.88345324
67Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.85838617
68Azoospermia (HP:0000027)1.84047524
6911 pairs of ribs (HP:0000878)1.81369904
70Asplenia (HP:0001746)1.80104958
71Abnormality of molar morphology (HP:0011070)1.78184076
72Abnormality of molar (HP:0011077)1.78184076
73Abnormality of the dental pulp (HP:0006479)1.77988923
74Decreased circulating renin level (HP:0003351)1.77010978
75J-shaped sella turcica (HP:0002680)1.76515746
76Aplasia/hypoplasia of the uterus (HP:0008684)1.75209834
77Oculomotor apraxia (HP:0000657)1.73520358
78Hyperventilation (HP:0002883)1.72131587
79Genital tract atresia (HP:0001827)1.71583795
80Aplasia/Hypoplasia of the fibula (HP:0006492)1.70844078
81Hypoplasia of the capital femoral epiphysis (HP:0003090)1.66768516
82Vaginal atresia (HP:0000148)1.65463366
83Short ribs (HP:0000773)1.64199568
84Abnormal drinking behavior (HP:0030082)1.63438054
85Polydipsia (HP:0001959)1.63438054
86Hypokalemic alkalosis (HP:0001949)1.63241870
87Preaxial hand polydactyly (HP:0001177)1.61844957
88Renal salt wasting (HP:0000127)1.61630031
89Gaze-evoked nystagmus (HP:0000640)1.61554739
90Tubulointerstitial fibrosis (HP:0005576)1.60888825
91Postaxial hand polydactyly (HP:0001162)1.60712517
92Inability to walk (HP:0002540)1.60523067
93Conjunctival telangiectasia (HP:0000524)1.58673605
94Abnormal urine output (HP:0012590)1.57777315
95Atelectasis (HP:0100750)1.56900379
96Renal cortical cysts (HP:0000803)1.55968669
97Gait imbalance (HP:0002141)1.54202135
98Renal dysplasia (HP:0000110)1.53710865
99Congenital primary aphakia (HP:0007707)1.53145442
100Fatigable weakness (HP:0003473)1.51241560
101Abnormality of the neuromuscular junction (HP:0003398)1.51241560
102Attenuation of retinal blood vessels (HP:0007843)1.51105768
103Retinitis pigmentosa (HP:0000510)1.50510919
104Keratoconus (HP:0000563)1.50076152
105Increased corneal curvature (HP:0100692)1.50076152
106Pendular nystagmus (HP:0012043)1.49914893
107Abnormality of renal excretion (HP:0011036)1.49912484
108Barrel-shaped chest (HP:0001552)1.48849714
109Constricted visual fields (HP:0001133)1.48199748
110Absent speech (HP:0001344)1.47397789
111Aplasia/Hypoplasia of the tongue (HP:0010295)1.46601300
112Deformed sella turcica (HP:0002681)1.46594758
113Pancreatic fibrosis (HP:0100732)1.46153566
114Hypomagnesemia (HP:0002917)1.46119789
115Hypoplasia of dental enamel (HP:0006297)1.46001448
116Selective tooth agenesis (HP:0001592)1.45823916
117Poor coordination (HP:0002370)1.44794044
118Microglossia (HP:0000171)1.44537197
119Abnormality of chloride homeostasis (HP:0011422)1.44491464
120Abnormality of ocular smooth pursuit (HP:0000617)1.44405343
121Short thorax (HP:0010306)1.43716507
122Hyperaldosteronism (HP:0000859)1.43234188
123Oligodactyly (hands) (HP:0001180)1.41237133
124Lissencephaly (HP:0001339)1.40924970
125Hyperkalemia (HP:0002153)1.40513775
126Abnormality of the labia minora (HP:0012880)1.40499885
127Fair hair (HP:0002286)1.40022012
128Broad-based gait (HP:0002136)1.39917808
129Asymmetric septal hypertrophy (HP:0001670)1.39652716
130Mitochondrial inheritance (HP:0001427)1.39522664
131Median cleft lip (HP:0000161)1.38630184
132Abnormality of renin-angiotensin system (HP:0000847)1.37515788
133Retinal dysplasia (HP:0007973)1.37503516
134Widely spaced teeth (HP:0000687)1.37355787
135Facial cleft (HP:0002006)1.37153515
136True hermaphroditism (HP:0010459)1.35862687
137Large eyes (HP:0001090)1.35325814
138Narrow forehead (HP:0000341)1.35057824
139Decreased motor nerve conduction velocity (HP:0003431)1.34945399
140Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.34913742
141Cystic liver disease (HP:0006706)1.34612494
142Impulsivity (HP:0100710)1.33543525
143Nephrogenic diabetes insipidus (HP:0009806)1.31416643
144Absent epiphyses (HP:0010577)1.29555211
145Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.29555211
146Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.27408133
147Nephropathy (HP:0000112)1.26969740
148Aplasia/Hypoplasia of the lens (HP:0008063)1.23795591
149Limb ataxia (HP:0002070)1.23525571
150Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.22999555
151Bell-shaped thorax (HP:0001591)1.22295006
152Pancreatic cysts (HP:0001737)1.21000465
153Spastic tetraparesis (HP:0001285)1.20832671
154Vascular calcification (HP:0004934)1.20755558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK26.59631954
2FRK4.15366729
3MAP4K23.82065415
4ADRBK23.77271899
5MST43.36180242
6TESK12.34628612
7TLK12.23843158
8BCR2.21260333
9PDK410.1474660
10PDK310.1474660
11GRK11.97763645
12NUAK11.88561040
13MAPKAPK31.79108423
14PNCK1.78110784
15ICK1.77498435
16PTK2B1.76435499
17STK391.73426676
18TXK1.70932820
19PRKCI1.70906316
20INSRR1.70830711
21TAOK31.70455428
22WNK41.69302603
23PRKD31.64471664
24MAP3K61.62459177
25MAP3K41.60710835
26OXSR11.57326846
27NME11.56443372
28ZAK1.51116110
29EPHA21.45558565
30MAPK131.37853211
31CASK1.31097227
32NEK21.28769919
33MUSK1.24862448
34MAP2K61.23812993
35STK38L1.22683701
36CCNB11.19316722
37MAP2K71.13232674
38CSNK1G11.13046571
39PAK31.12799935
40TEC1.11913690
41PRKCE1.09761739
42CSNK1G21.06909777
43TRIM281.02174584
44CSNK1G30.98827445
45MAP2K30.97300393
46BCKDK0.95578601
47PASK0.92110029
48CSNK1A1L0.89590015
49DYRK20.86488872
50MAPK150.86321847
51FGFR20.84120815
52PHKG10.83347815
53PHKG20.83347815
54STK100.80776066
55CDC70.80541816
56DAPK20.80148795
57STK30.79136484
58PDK10.78948747
59PIM20.78134928
60CAMKK20.76854296
61NLK0.76839226
62ACVR1B0.73257842
63ERBB20.72875064
64LMTK20.70161518
65WNK10.67815543
66STK240.67032228
67MAP2K40.65495211
68STK380.63882859
69MKNK20.62279934
70IRAK10.61316976
71GRK60.60608820
72ZAP700.55493193
73ERBB30.52329702
74MARK30.50091431
75PRKACA0.49470027
76TYRO30.48146897
77TTK0.47900329
78MARK10.46661852
79MAP3K120.46473671
80EPHA30.45609885
81CSNK1A10.44730576
82VRK10.44611239
83BMPR1B0.43943476
84CSK0.42256827
85ABL10.41404688
86DYRK1B0.41375524
87RPS6KA50.41317991
88MAP3K50.41160422
89PRKCD0.38415668
90ITK0.37799636
91PLK40.37499100
92IKBKE0.36994085
93IGF1R0.33731360
94CAMK1G0.33309920
95WEE10.32371231
96CHEK10.31719602
97MINK10.31717392
98IKBKB0.31409149
99PLK30.30226117
100CHEK20.29963705
101MAPKAPK50.28616715
102NTRK30.28156652
103CAMK2G0.27940296
104TIE10.27605464
105PRKAA20.26783658
106ATR0.26505127
107MARK20.26019808
108SYK0.25464547
109PLK10.25399868
110DYRK1A0.25220456
111TRIB30.22600038
112RIPK40.22306241
113CDK30.21423389
114PRKG20.20425641
115CAMKK10.20022277
116IRAK20.19764940
117ATM0.19069810
118PINK10.18533591
119DYRK30.16907404
120MATK0.16801933
121SRPK10.15581399
122KIT0.15208007
123PAK20.13236044
124NTRK20.12502372
125STK110.12364574
126NEK60.12067817
127RET0.10382650
128PDPK10.09506188
129ADRBK10.09473499
130CAMK10.09434021
131PAK10.08901699
132PRKCQ0.08475677
133PTK60.07679110
134WNK30.07319211
135PRKG10.06632240
136PRKAA10.06128658
137PRKCG0.05781774
138PIM10.05632910
139MTOR0.05533602
140PRKACB0.05400003
141RPS6KB10.04756108
142YES10.03725586
143PRKACG0.02666052
144MAPK80.01456223
145MAP3K70.01157249
146PRKCB0.00968348
147GSK3B0.00519010
148MAPK100.00263342
149FER-0.0338945
150LCK-0.0322791
151PKN1-0.0281111
152CSNK1D-0.0271261
153CSNK2A1-0.0268273
154PRKCA-0.0255580
155CAMK2A-0.0255199
156STK16-0.0252437
157CDK1-0.0239160
158PLK2-0.0236609
159MAPK4-0.0155040
160CDK2-0.0152310
161PRKCZ-0.0089785
162INSR-0.0062912
163RPS6KA3-0.0057196
164CDK12-0.0053150
165PRKDC-0.0009067
166BRSK2-0.0002154

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.14032611
2Pyruvate metabolism_Homo sapiens_hsa006204.63362610
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.10075625
4Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.62702033
5Propanoate metabolism_Homo sapiens_hsa006403.34446030
6Caffeine metabolism_Homo sapiens_hsa002323.01140883
7Glucagon signaling pathway_Homo sapiens_hsa049222.96105481
8Basal transcription factors_Homo sapiens_hsa030222.94388936
9Fanconi anemia pathway_Homo sapiens_hsa034602.62871091
10Dorso-ventral axis formation_Homo sapiens_hsa043202.58483905
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.44074891
12Phototransduction_Homo sapiens_hsa047442.41393267
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.34896720
14Nitrogen metabolism_Homo sapiens_hsa009102.31399510
15beta-Alanine metabolism_Homo sapiens_hsa004102.22441195
16Selenocompound metabolism_Homo sapiens_hsa004502.20302228
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17752424
18Fatty acid biosynthesis_Homo sapiens_hsa000612.13840771
19Oocyte meiosis_Homo sapiens_hsa041142.07007990
20Linoleic acid metabolism_Homo sapiens_hsa005912.05296959
21Histidine metabolism_Homo sapiens_hsa003402.05147631
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02536113
23Pentose phosphate pathway_Homo sapiens_hsa000302.00993114
24Butanoate metabolism_Homo sapiens_hsa006502.00655049
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.98484579
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.92963697
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.91531554
28Oxidative phosphorylation_Homo sapiens_hsa001901.81656162
29Huntingtons disease_Homo sapiens_hsa050161.80284480
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.78518484
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.74017578
32Glycerolipid metabolism_Homo sapiens_hsa005611.68807883
33Renin secretion_Homo sapiens_hsa049241.61710606
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.59332299
35Nicotine addiction_Homo sapiens_hsa050331.57429512
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.55380147
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53954175
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53069610
39Peroxisome_Homo sapiens_hsa041461.52408321
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49880805
41Tyrosine metabolism_Homo sapiens_hsa003501.44563905
42Carbon metabolism_Homo sapiens_hsa012001.44034687
43Phenylalanine metabolism_Homo sapiens_hsa003601.41692418
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.34540749
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33520941
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32717114
47Tryptophan metabolism_Homo sapiens_hsa003801.30790502
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29912212
49Amphetamine addiction_Homo sapiens_hsa050311.26900038
50PPAR signaling pathway_Homo sapiens_hsa033201.24020820
51Protein export_Homo sapiens_hsa030601.21793862
52Olfactory transduction_Homo sapiens_hsa047401.21330402
53Regulation of autophagy_Homo sapiens_hsa041401.20863131
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.18190236
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17382588
56Glycerophospholipid metabolism_Homo sapiens_hsa005641.16635171
57Cyanoamino acid metabolism_Homo sapiens_hsa004601.12053805
58Sphingolipid metabolism_Homo sapiens_hsa006001.11367215
59Parkinsons disease_Homo sapiens_hsa050121.10071760
60Intestinal immune network for IgA production_Homo sapiens_hsa046721.05536994
61mRNA surveillance pathway_Homo sapiens_hsa030151.05048609
62Antigen processing and presentation_Homo sapiens_hsa046121.04986442
63Inositol phosphate metabolism_Homo sapiens_hsa005621.00726773
64Cardiac muscle contraction_Homo sapiens_hsa042601.00376027
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00301465
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99991786
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98397502
68ABC transporters_Homo sapiens_hsa020100.97810634
69Biosynthesis of amino acids_Homo sapiens_hsa012300.96164374
70Ether lipid metabolism_Homo sapiens_hsa005650.94748850
71RNA transport_Homo sapiens_hsa030130.92959232
72Morphine addiction_Homo sapiens_hsa050320.88046989
73Sulfur metabolism_Homo sapiens_hsa009200.86343676
74Estrogen signaling pathway_Homo sapiens_hsa049150.85529968
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83989932
76Primary immunodeficiency_Homo sapiens_hsa053400.83717076
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83311496
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.80645305
79Fatty acid degradation_Homo sapiens_hsa000710.78230945
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78229683
81Alzheimers disease_Homo sapiens_hsa050100.77999572
82Serotonergic synapse_Homo sapiens_hsa047260.77754331
83Steroid biosynthesis_Homo sapiens_hsa001000.77480144
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77078795
85VEGF signaling pathway_Homo sapiens_hsa043700.76151393
86Calcium signaling pathway_Homo sapiens_hsa040200.75833734
87Fatty acid metabolism_Homo sapiens_hsa012120.75400634
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75362174
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74673111
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.73019218
91Long-term potentiation_Homo sapiens_hsa047200.71412955
92Arginine and proline metabolism_Homo sapiens_hsa003300.70625484
93N-Glycan biosynthesis_Homo sapiens_hsa005100.70289060
94Purine metabolism_Homo sapiens_hsa002300.70239112
95Fat digestion and absorption_Homo sapiens_hsa049750.68818421
96Type I diabetes mellitus_Homo sapiens_hsa049400.68370661
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67222745
98Asthma_Homo sapiens_hsa053100.67161790
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66459003
100RNA polymerase_Homo sapiens_hsa030200.65057295
101Fructose and mannose metabolism_Homo sapiens_hsa000510.64863399
102Circadian entrainment_Homo sapiens_hsa047130.63449809
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62830858
104Mineral absorption_Homo sapiens_hsa049780.62160348
105Chemical carcinogenesis_Homo sapiens_hsa052040.61984170
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60857205
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59161841
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59133025
109Proteasome_Homo sapiens_hsa030500.58517245
110Ovarian steroidogenesis_Homo sapiens_hsa049130.57257340
111Bile secretion_Homo sapiens_hsa049760.56097200
112Circadian rhythm_Homo sapiens_hsa047100.55019802
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53234189
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51078564
115Glutathione metabolism_Homo sapiens_hsa004800.50430533
116GABAergic synapse_Homo sapiens_hsa047270.49660957
117Homologous recombination_Homo sapiens_hsa034400.49063758
118Legionellosis_Homo sapiens_hsa051340.48658930
119Hedgehog signaling pathway_Homo sapiens_hsa043400.47762438
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47737522
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46860279
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45595035
123Arachidonic acid metabolism_Homo sapiens_hsa005900.45437096
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.44780477
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44701312
126Salivary secretion_Homo sapiens_hsa049700.43898063
127B cell receptor signaling pathway_Homo sapiens_hsa046620.43638720
128Systemic lupus erythematosus_Homo sapiens_hsa053220.43286950
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40345138
130Vitamin digestion and absorption_Homo sapiens_hsa049770.40099196
131Taste transduction_Homo sapiens_hsa047420.37614091
132One carbon pool by folate_Homo sapiens_hsa006700.36803238
133Glutamatergic synapse_Homo sapiens_hsa047240.36430733
134Retinol metabolism_Homo sapiens_hsa008300.36274588
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35825674
136Metabolic pathways_Homo sapiens_hsa011000.34445713
137Tight junction_Homo sapiens_hsa045300.31998300
138Salmonella infection_Homo sapiens_hsa051320.31920394
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31722098
140Hematopoietic cell lineage_Homo sapiens_hsa046400.31453493
141Synaptic vesicle cycle_Homo sapiens_hsa047210.31439517
142Starch and sucrose metabolism_Homo sapiens_hsa005000.31408076
143Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30660426
144Pancreatic secretion_Homo sapiens_hsa049720.28554934
145Shigellosis_Homo sapiens_hsa051310.28394769
146Gastric acid secretion_Homo sapiens_hsa049710.28380635
147Insulin secretion_Homo sapiens_hsa049110.27459894
148Graft-versus-host disease_Homo sapiens_hsa053320.26964261
149Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26704406
150Platelet activation_Homo sapiens_hsa046110.26531201
151Endocytosis_Homo sapiens_hsa041440.26241372
152Alcoholism_Homo sapiens_hsa050340.25479090
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24924290
154Dopaminergic synapse_Homo sapiens_hsa047280.22073218
155Thyroid hormone synthesis_Homo sapiens_hsa049180.21830749
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21359008
157T cell receptor signaling pathway_Homo sapiens_hsa046600.21227560
158Collecting duct acid secretion_Homo sapiens_hsa049660.20685595
159Wnt signaling pathway_Homo sapiens_hsa043100.20678811
160Adipocytokine signaling pathway_Homo sapiens_hsa049200.20216779
161Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18906837
162AMPK signaling pathway_Homo sapiens_hsa041520.17776295
163RNA degradation_Homo sapiens_hsa030180.17448435
164Oxytocin signaling pathway_Homo sapiens_hsa049210.17127150

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